WO2020232047A1 - Dispositif de spectroscopie par réflectance diffuse hybride pour mesurer un spf - Google Patents

Dispositif de spectroscopie par réflectance diffuse hybride pour mesurer un spf Download PDF

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Publication number
WO2020232047A1
WO2020232047A1 PCT/US2020/032564 US2020032564W WO2020232047A1 WO 2020232047 A1 WO2020232047 A1 WO 2020232047A1 US 2020032564 W US2020032564 W US 2020032564W WO 2020232047 A1 WO2020232047 A1 WO 2020232047A1
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WO
WIPO (PCT)
Prior art keywords
sunscreen
skin
uva
leds
vitro
Prior art date
Application number
PCT/US2020/032564
Other languages
English (en)
Inventor
Eduardo C. RUVOLO
Original Assignee
Beiersdorf Ag
MUENSTERER, Heribert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag, MUENSTERER, Heribert filed Critical Beiersdorf Ag
Publication of WO2020232047A1 publication Critical patent/WO2020232047A1/fr

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/42Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/429Photometry, e.g. photographic exposure meter using electric radiation detectors applied to measurement of ultraviolet light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/027Control of working procedures of a spectrometer; Failure detection; Bandwidth calculation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/42Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G01J2003/102Plural sources
    • G01J2003/104Monochromatic plural sources
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G01J2003/102Plural sources
    • G01J2003/106Plural sources the two sources being alternating or selectable, e.g. in two ranges or line:continuum
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/42Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G01J2003/425Reflectance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4742Details of optical heads therefor, e.g. using optical fibres comprising optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/02Mechanical
    • G01N2201/022Casings
    • G01N2201/0221Portable; cableless; compact; hand-held
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/062LED's

Definitions

  • This disclosure relates to a diffuse reflectance spectroscopy device capable of measuring UVA protection factor and SPF of sunscreen. More particularly, this disclosure relates to a handheld LED-based device that utilizes hybrid diffuse reflectance spectroscopy to determine the UVA protection factor and SPF of sunscreen applied to skin.
  • the UVA wavelengths are 320-400 nm. In some embodiments, an incremental step of UV light sequentially emitted from the plurality of LEDs is 5-20 nm.
  • the computer is a smart phone. In some embodiments, the computer sends the SPF of the sunscreen to the handheld device for display.
  • a method comprises: illuminating an area of skin with a plurality of LEDs, wherein each LED emits light at a different UVA wavelength; collecting first reflectance signals re-emitted from the area of skin; applying sunscreen to the area of skin; illuminating the area of skin with sunscreen with the plurality of LEDs; collecting second reflectance signals re-emitted from the area of skin with sunscreen; determining an in vivo diffuse reflectance spectroscopy UVA absorbance spectrum from the first and second reflectance signals; obtaining an in vitro UV absorbance spectrum for the sunscreen from a library comprising in vitro UV absorbance spectrums for a plurality of sunscreens; grafting the in vitro UV absorbance spectrum to the in vivo UVA absorbance spectrum to obtain a full UV absorbance spectrum; determining the SPF of the sunscreen using the full UV absorbance spectrum; and displaying the SPF of the sunscreen.
  • the computer or smart phone can obtain the in vitro UV absorbance spectrum information for the specific sunscreen that was applied to the skin from the server. After all the calculations have been completed, the computer or smart phone can send the SPF information to the LED DRS device for display.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Multimedia (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un système et un dispositif capables de prédire le SPF in vivo pour un produit d'écran solaire donné sans induire de coup de soleil sur un individu. Le système utilise des DEL pour mesurer le spectre d'absorbance UVA sur la peau à l'aide d'une spectroscopie par réflectance diffuse et fixe le spectre d'absorbance UVB in vitro au spectre d'absorbance UVA pour prédire le SPF in vivo de l'écran solaire.
PCT/US2020/032564 2019-05-16 2020-05-13 Dispositif de spectroscopie par réflectance diffuse hybride pour mesurer un spf WO2020232047A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962849062P 2019-05-16 2019-05-16
US62/849,062 2019-05-16

Publications (1)

Publication Number Publication Date
WO2020232047A1 true WO2020232047A1 (fr) 2020-11-19

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Family Applications (1)

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PCT/US2020/032564 WO2020232047A1 (fr) 2019-05-16 2020-05-13 Dispositif de spectroscopie par réflectance diffuse hybride pour mesurer un spf

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3865052A1 (fr) * 2020-02-11 2021-08-18 Courage + Khazaka Electronic GmbH Système de mesure et procédé de mesure pour déterminer le facteur de protection d'une crème solaire
DE102020119026A1 (de) 2020-07-17 2022-01-20 Courage + Khazaka Electronic Gmbh Messsystem und Messverfahren
WO2022216647A1 (fr) * 2021-04-07 2022-10-13 The Procter & Gamble Company Systèmes et procédés d'imagerie par ultraviolets
EP4372364A1 (fr) * 2022-11-21 2024-05-22 Courage + Khazaka electronic GmbH Dispositif et procédé de détermination d'un facteur de protection
DE102022130758A1 (de) 2022-11-21 2024-05-23 Courage + Khazaka Electronic Gmbh Messsystem und messverfahren

Citations (5)

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US20170356848A1 (en) * 2014-11-25 2017-12-14 Ge Healthcare Bio-Sciences Ab Intergration of Fluorescence Detection Capability into Light Absorbance Measurement Apparatus
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US20180024002A1 (en) * 2015-02-19 2018-01-25 Sony Corporation Method, electronic device and system for monitoring a skin surface condition
US20180008172A1 (en) * 2015-03-19 2018-01-11 The Regents Of The University Of Michigan System for analyzing tissue
US20180321139A1 (en) * 2015-10-20 2018-11-08 Courage + Khazaka Electronic Gmbh Optically ascertaining the sun protection factor of sunscreens or other radiation protection agents
US20190125258A1 (en) * 2017-10-31 2019-05-02 L'oreal Sunscreen formulation and systems for sun protection and related methods of use

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Title
ANONYMOUS: "Suche - BfR", 1 January 2020 (2020-01-01), XP055708145, Retrieved from the Internet <URL:https://www.bfr.bund.de/de/suche.html?search query!=sun+protection+factor> [retrieved on 20200623] *
EDUARDO RUVOLO JR. ET AL., PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, vol. 25, 2009, pages 298 - 304
EDUARDO RUVOLO JR. ET AL., PHOTODERMATOLOGY, PHOTOIMMUNOLOGY, & PHOTOMEDICINE, vol. 30, 2014, pages 202 - 211
EDUARDO RUVOLO JUNIOR ET AL: "New noninvasive approach assessing in vivo sun protection factor (SPF) using diffuse reflectance spectroscopy (DRS) and in vitro transmission", PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, vol. 30, no. 4, 19 August 2014 (2014-08-19), United States, United Kingdom, pages 202 - 211, XP055339170, ISSN: 0905-4383, DOI: 10.1111/phpp.12105 *
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3865052A1 (fr) * 2020-02-11 2021-08-18 Courage + Khazaka Electronic GmbH Système de mesure et procédé de mesure pour déterminer le facteur de protection d'une crème solaire
DE102020119026A1 (de) 2020-07-17 2022-01-20 Courage + Khazaka Electronic Gmbh Messsystem und Messverfahren
WO2022216647A1 (fr) * 2021-04-07 2022-10-13 The Procter & Gamble Company Systèmes et procédés d'imagerie par ultraviolets
EP4372364A1 (fr) * 2022-11-21 2024-05-22 Courage + Khazaka electronic GmbH Dispositif et procédé de détermination d'un facteur de protection
DE102022130758A1 (de) 2022-11-21 2024-05-23 Courage + Khazaka Electronic Gmbh Messsystem und messverfahren

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