WO2020223527A3 - Élimination de conservateur de gouttes oculaires - Google Patents

Élimination de conservateur de gouttes oculaires Download PDF

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Publication number
WO2020223527A3
WO2020223527A3 PCT/US2020/030801 US2020030801W WO2020223527A3 WO 2020223527 A3 WO2020223527 A3 WO 2020223527A3 US 2020030801 W US2020030801 W US 2020030801W WO 2020223527 A3 WO2020223527 A3 WO 2020223527A3
Authority
WO
WIPO (PCT)
Prior art keywords
preservative
eye drops
oxpo
drug
preservative removal
Prior art date
Application number
PCT/US2020/030801
Other languages
English (en)
Other versions
WO2020223527A2 (fr
Inventor
Michael Wilson
Michael Williams
Deniz HAY
Michael Malanga
Original Assignee
TearClear Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TearClear Corp. filed Critical TearClear Corp.
Priority to EP20798350.3A priority Critical patent/EP3962621A4/fr
Priority to JP2021564194A priority patent/JP2022532854A/ja
Priority to KR1020217039479A priority patent/KR20220005070A/ko
Priority to CA3138304A priority patent/CA3138304A1/fr
Priority to MX2021013381A priority patent/MX2021013381A/es
Priority to CN202080048648.XA priority patent/CN114096339B/zh
Priority to SG11202112122YA priority patent/SG11202112122YA/en
Priority to AU2020266590A priority patent/AU2020266590A1/en
Publication of WO2020223527A2 publication Critical patent/WO2020223527A2/fr
Publication of WO2020223527A3 publication Critical patent/WO2020223527A3/fr
Priority to IL287662A priority patent/IL287662A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0004—Organic membrane manufacture by agglomeration of particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0004—Organic membrane manufacture by agglomeration of particles
    • B01D67/00041—Organic membrane manufacture by agglomeration of particles by sintering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/147—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing embedded adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/261—Polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/52—Sorbents specially adapted for preparative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/56—Use in the form of a bed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un bouchon particulaire pour éliminer un conservateur d'une solution, d'une suspension ou d'une émulsion comprenant un médicament. Le bouchon comprend des microparticules de polyoléfine oxydée (OxPO). Les microparticules sont des agrégats rigides de forme irrégulière et sont dimensionnées et tassées pour produire une perméabilité hydraulique supérieure à 0,01 Da. Les OxPO ont absorbé des parties d'un conservateur à éliminer et/ou d'un médicament destiné à être administré en solution, tout comme le copolymère.
PCT/US2020/030801 2019-05-02 2020-04-30 Élimination de conservateur de gouttes oculaires WO2020223527A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP20798350.3A EP3962621A4 (fr) 2019-05-02 2020-04-30 Élimination de conservateur de gouttes oculaires
JP2021564194A JP2022532854A (ja) 2019-05-02 2020-04-30 点眼薬からの防腐剤の除去
KR1020217039479A KR20220005070A (ko) 2019-05-02 2020-04-30 점안제로부터의 보존제 제거
CA3138304A CA3138304A1 (fr) 2019-05-02 2020-04-30 Elimination de conservateur de gouttes oculaires
MX2021013381A MX2021013381A (es) 2019-05-02 2020-04-30 Eliminacion de conservante de gotas para los ojos.
CN202080048648.XA CN114096339B (zh) 2019-05-02 2020-04-30 从滴眼剂中去除防腐剂
SG11202112122YA SG11202112122YA (en) 2019-05-02 2020-04-30 Preservative removal from eye drops
AU2020266590A AU2020266590A1 (en) 2019-05-02 2020-04-30 Preservative removal from eye drops
IL287662A IL287662A (en) 2019-05-02 2021-10-28 Eye drops shift removal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962842071P 2019-05-02 2019-05-02
US62/842,071 2019-05-02

Publications (2)

Publication Number Publication Date
WO2020223527A2 WO2020223527A2 (fr) 2020-11-05
WO2020223527A3 true WO2020223527A3 (fr) 2021-04-29

Family

ID=73017081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/030801 WO2020223527A2 (fr) 2019-05-02 2020-04-30 Élimination de conservateur de gouttes oculaires

Country Status (13)

Country Link
US (2) US11723838B2 (fr)
EP (1) EP3962621A4 (fr)
JP (1) JP2022532854A (fr)
KR (1) KR20220005070A (fr)
CN (1) CN114096339B (fr)
AR (1) AR118828A1 (fr)
AU (1) AU2020266590A1 (fr)
CA (1) CA3138304A1 (fr)
IL (1) IL287662A (fr)
MA (1) MA55095A (fr)
MX (1) MX2021013381A (fr)
SG (1) SG11202112122YA (fr)
WO (1) WO2020223527A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA55095A (fr) 2019-05-02 2022-03-09 Tearclear Corp Élimination de conservateur de gouttes oculaires
AU2020405238A1 (en) 2019-12-19 2022-07-14 TearClear Corp. Preservative removal from eye drops
AU2021322232A1 (en) 2020-08-05 2023-03-23 TearClear Corp. Systems and methods for preservative removal from ophthalmic formulations

Citations (8)

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Publication number Priority date Publication date Assignee Title
US5056689A (en) * 1990-01-08 1991-10-15 Ciba-Geigy Corporation Apparatus for removing components from solutions
WO2005066219A1 (fr) * 2003-04-01 2005-07-21 Honeywell International Inc. Procede pour oxyder polyethylene lineaire de bas poids moleculaire
US20100285192A1 (en) * 2008-01-29 2010-11-11 Universite Catholique De Louvain Method for filtering a liquid
US20100305259A1 (en) * 2009-05-29 2010-12-02 George Rodriguez Polyolefin Adhesive Compositions And Method of Making Thereof
US20130127071A1 (en) * 2011-11-18 2013-05-23 Nitto Denko Corporation Epoxy resin composition for semiconductor encapsulation and semiconductor device using the same
US20170224531A1 (en) * 2014-08-13 2017-08-10 University Of Florida Research Foundation, Inc. Preservative Removal from Eye Drops
WO2018102817A1 (fr) * 2016-12-02 2018-06-07 University Of Florida Research Foundation, Inc. Élimination d'un conservateur dans des gouttes pour les yeux
WO2019060846A1 (fr) * 2017-09-25 2019-03-28 University Of Florida Research Foundation, Inc. Élimination du conservateur de gouttes oculaires contenant des médicaments hydrophiles

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US3322711A (en) 1963-10-17 1967-05-30 Allied Chem Polymer oxidation process and emulsion therefrom
GB1087915A (en) 1964-03-09 1967-10-18 Allied Chem Improvements relating to the production of oxidized polyethylene
DE3112163A1 (de) 1981-03-27 1982-10-14 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von emulgierbarem polyethylen durch oxidation von polyethylen im wirbelbettreaktor
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US5401811A (en) 1994-05-03 1995-03-28 Eastman Chemical Company Continuous process for the oxidation of polyethylene
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MA55095A (fr) 2019-05-02 2022-03-09 Tearclear Corp Élimination de conservateur de gouttes oculaires
AU2021322232A1 (en) 2020-08-05 2023-03-23 TearClear Corp. Systems and methods for preservative removal from ophthalmic formulations

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5056689A (en) * 1990-01-08 1991-10-15 Ciba-Geigy Corporation Apparatus for removing components from solutions
WO2005066219A1 (fr) * 2003-04-01 2005-07-21 Honeywell International Inc. Procede pour oxyder polyethylene lineaire de bas poids moleculaire
US20100285192A1 (en) * 2008-01-29 2010-11-11 Universite Catholique De Louvain Method for filtering a liquid
US20100305259A1 (en) * 2009-05-29 2010-12-02 George Rodriguez Polyolefin Adhesive Compositions And Method of Making Thereof
US20130127071A1 (en) * 2011-11-18 2013-05-23 Nitto Denko Corporation Epoxy resin composition for semiconductor encapsulation and semiconductor device using the same
US20170224531A1 (en) * 2014-08-13 2017-08-10 University Of Florida Research Foundation, Inc. Preservative Removal from Eye Drops
WO2018102817A1 (fr) * 2016-12-02 2018-06-07 University Of Florida Research Foundation, Inc. Élimination d'un conservateur dans des gouttes pour les yeux
WO2019060846A1 (fr) * 2017-09-25 2019-03-28 University Of Florida Research Foundation, Inc. Élimination du conservateur de gouttes oculaires contenant des médicaments hydrophiles

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* Cited by examiner, † Cited by third party
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ANONYMOUS: "Polyethylene waxes, technical data", DEUREX THE WAX COMPANY, 2020, pages 1 - 8, XP055867778, Retrieved from the Internet <URL:https://www.deurex.com/waxes/polyethylenewaxes/technical-data> *

Also Published As

Publication number Publication date
CN114096339B (zh) 2024-04-12
EP3962621A4 (fr) 2022-11-30
EP3962621A2 (fr) 2022-03-09
CA3138304A1 (fr) 2020-11-05
MX2021013381A (es) 2021-11-25
WO2020223527A2 (fr) 2020-11-05
US20200345583A1 (en) 2020-11-05
MA55095A (fr) 2022-03-09
US20200346186A1 (en) 2020-11-05
JP2022532854A (ja) 2022-07-20
KR20220005070A (ko) 2022-01-12
AR118828A1 (es) 2021-11-03
SG11202112122YA (en) 2021-11-29
US11723838B2 (en) 2023-08-15
CN114096339A (zh) 2022-02-25
AU2020266590A1 (en) 2021-12-16
IL287662A (en) 2021-12-01
US11096865B2 (en) 2021-08-24

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