WO2020218379A1 - Composition favorisant la sécrétion de glp-1 - Google Patents

Composition favorisant la sécrétion de glp-1 Download PDF

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Publication number
WO2020218379A1
WO2020218379A1 PCT/JP2020/017399 JP2020017399W WO2020218379A1 WO 2020218379 A1 WO2020218379 A1 WO 2020218379A1 JP 2020017399 W JP2020017399 W JP 2020017399W WO 2020218379 A1 WO2020218379 A1 WO 2020218379A1
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WO
WIPO (PCT)
Prior art keywords
glp
sample
emulsifier
concentration
reba
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PCT/JP2020/017399
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English (en)
Japanese (ja)
Inventor
聡一郎 浦井
浩二 長尾
芳明 横尾
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サントリーホールディングス株式会社
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Filing date
Publication date
Application filed by サントリーホールディングス株式会社 filed Critical サントリーホールディングス株式会社
Priority to CN202080031195.XA priority Critical patent/CN113747921A/zh
Priority to US17/606,181 priority patent/US20220211731A1/en
Priority to EP20794938.9A priority patent/EP3960201A4/fr
Priority to AU2020263747A priority patent/AU2020263747A1/en
Priority to SG11202111833YA priority patent/SG11202111833YA/en
Priority to JP2021516178A priority patent/JP7450612B2/ja
Publication of WO2020218379A1 publication Critical patent/WO2020218379A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/332—Promoters of weight control and weight loss

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Il a été attendu de développer un meilleur composant sécrétagogue de GLP-1. La présente invention concerne une composition pour favoriser la sécrétion de GLP-1 qui contient des particules émulsifiées comprenant un composant sécrétagogue de GLP-1 amphiphile et un émulsifiant, l'émulsifiant étant un émulsifiant de type huile dans l'eau et le composant sécrétagogue de GLP-1 étant incorporé dans les particules émulsifiées.
PCT/JP2020/017399 2019-04-26 2020-04-22 Composition favorisant la sécrétion de glp-1 WO2020218379A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202080031195.XA CN113747921A (zh) 2019-04-26 2020-04-22 Glp-1分泌促进用组合物
US17/606,181 US20220211731A1 (en) 2019-04-26 2020-04-22 Composition for promoting glp-1 secretion
EP20794938.9A EP3960201A4 (fr) 2019-04-26 2020-04-22 Composition favorisant la sécrétion de glp-1
AU2020263747A AU2020263747A1 (en) 2019-04-26 2020-04-22 Composition for promoting GLP-1 secretion
SG11202111833YA SG11202111833YA (en) 2019-04-26 2020-04-22 Composition for promoting glp-1 secretion
JP2021516178A JP7450612B2 (ja) 2019-04-26 2020-04-22 Ｇｌｐ－１分泌促進用組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-086867 2019-04-26
JP2019086867 2019-04-26

Publications (1)

Publication Number Publication Date
WO2020218379A1 true WO2020218379A1 (fr) 2020-10-29

Family

ID=72942505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/017399 WO2020218379A1 (fr) 2019-04-26 2020-04-22 Composition favorisant la sécrétion de glp-1

Country Status (8)

Country Link
US (1) US20220211731A1 (fr)
EP (1) EP3960201A4 (fr)
JP (1) JP7450612B2 (fr)
CN (1) CN113747921A (fr)
AU (1) AU2020263747A1 (fr)
SG (1) SG11202111833YA (fr)
TW (1) TWI790434B (fr)
WO (1) WO2020218379A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220226354A1 (en) * 2019-04-26 2022-07-21 Suntory Holdings Limited Glp-1 secretion-promoting composition

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139309A (ja) * 1983-01-28 1984-08-10 Nonogawa Shoji:Kk 乳化化粧料
JPH01176443A (ja) * 1987-12-28 1989-07-12 Nonogawa Shoji:Kk 多価アルコール中油型乳化組成物及び水中油型乳化組成物
US20120196019A1 (en) * 2011-02-01 2012-08-02 Jingang Shi Stevia sweetener with a surfactant
US20150237901A1 (en) * 2014-02-21 2015-08-27 James and Carol May Family, LLLP Compositions and methods for the solubilization of stevia glycosides
WO2017018404A1 (fr) 2015-07-27 2017-02-02 サントリーホールディングス株式会社 Composition contenant un dipeptide cyclique et un édulcorant
JP2017504343A (ja) * 2014-01-29 2017-02-09 カーギル・インコーポレイテッド 濃縮シロップ中のステビオール配糖体の安定懸濁液
WO2017159725A1 (fr) 2016-03-16 2017-09-21 サントリーホールディングス株式会社 Composition pour favoriser la sécrétion de glp-1, et son procédé de fabrication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090131316A1 (en) * 2005-09-30 2009-05-21 Morinaga Milk Industry Co., Ltd. Glucagon-like peptide-1 secretagogue, glucagon-like peptide-1 secretagogue food or drink, inhibitor of postprandial rise in blood glucose, and inhibitory food or drink of postprandial rise in blood glucose
CN107072237B (zh) * 2014-09-02 2021-12-14 谱赛科有限责任公司 甜菊提取物
JP7241752B2 (ja) * 2017-08-08 2023-03-17 イーバイオ ニュートリショナル サイエンシズ リミティド ライアビリティ カンパニー 甘味料組成物およびその製造方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139309A (ja) * 1983-01-28 1984-08-10 Nonogawa Shoji:Kk 乳化化粧料
JPH01176443A (ja) * 1987-12-28 1989-07-12 Nonogawa Shoji:Kk 多価アルコール中油型乳化組成物及び水中油型乳化組成物
US20120196019A1 (en) * 2011-02-01 2012-08-02 Jingang Shi Stevia sweetener with a surfactant
JP2017504343A (ja) * 2014-01-29 2017-02-09 カーギル・インコーポレイテッド 濃縮シロップ中のステビオール配糖体の安定懸濁液
US20150237901A1 (en) * 2014-02-21 2015-08-27 James and Carol May Family, LLLP Compositions and methods for the solubilization of stevia glycosides
WO2017018404A1 (fr) 2015-07-27 2017-02-02 サントリーホールディングス株式会社 Composition contenant un dipeptide cyclique et un édulcorant
WO2017159725A1 (fr) 2016-03-16 2017-09-21 サントリーホールディングス株式会社 Composition pour favoriser la sécrétion de glp-1, et son procédé de fabrication

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DINA RIPKEN, VAN DER WIELEN NIKKIE, WORTELBOER HELEEN M., MEIJERINK JOCELIJN, WITKAMP RENGER F., HENDRIKS HENK F. J.: "Steviol Glycoside Rebaudioside A Induces Glucagon-like Peptide-1 and Peptide YY Release in a Porcine ex Vivo Intestinal Model", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 62, no. 33, 25 July 2014 (2014-07-25), pages 8365 - 8370, XP055758797, ISSN: 0021-8561, DOI: 10.1021/jf501105w *
See also references of EP3960201A4
TOSHIYUKI SUZUKI, J. SOC. COSMET. JPN., vol. 44, no. 2, 2010
YOUNG-SUN LEE ET AL.: "Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control", MEDIATORS OF INFLAMMATION, vol. 2016, pages 11

Also Published As

Publication number Publication date
TW202106310A (zh) 2021-02-16
EP3960201A1 (fr) 2022-03-02
AU2020263747A1 (en) 2021-12-09
CN113747921A (zh) 2021-12-03
US20220211731A1 (en) 2022-07-07
TWI790434B (zh) 2023-01-21
SG11202111833YA (en) 2021-11-29
JP7450612B2 (ja) 2024-03-15
JPWO2020218379A1 (fr) 2020-10-29
EP3960201A4 (fr) 2023-01-25

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