WO2020213819A1 - 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템 - Google Patents
손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템 Download PDFInfo
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- WO2020213819A1 WO2020213819A1 PCT/KR2020/000469 KR2020000469W WO2020213819A1 WO 2020213819 A1 WO2020213819 A1 WO 2020213819A1 KR 2020000469 W KR2020000469 W KR 2020000469W WO 2020213819 A1 WO2020213819 A1 WO 2020213819A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0484—Garment electrodes worn by the patient
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K17/00—Electronic switching or gating, i.e. not by contact-making and –breaking
- H03K17/51—Electronic switching or gating, i.e. not by contact-making and –breaking characterised by the components used
- H03K17/56—Electronic switching or gating, i.e. not by contact-making and –breaking characterised by the components used by the use, as active elements, of semiconductor devices
- H03K17/567—Circuits characterised by the use of more than one type of semiconductor device, e.g. BIMOS, composite devices such as IGBT
Definitions
- the present invention relates to a multi-channel stimulation system for regeneration of damaged corneal nerves, and more particularly, by applying a current pulse signal as a stimulation signal through a multi-channel attached to a plurality of areas close to the eye, effectively regenerating damaged corneal nerves. It relates to a multi-channel stimulation system for regeneration of damaged corneal nerves.
- nerve regeneration can be regulated by its intrinsic characteristics, and that in the regeneration of peripheral nerves, the regeneration of nerves and tissues can be accelerated by using microscopic electrical stimulation.
- an object of the present invention is to effectively treat damaged corneal nerves by applying a current pulse signal as a stimulation signal through a multi-channel attached to a plurality of areas close to the eye.
- a current pulse signal as a stimulation signal
- a multi-channel attached to a plurality of areas close to the eye.
- the multi-channel stimulation system for regenerating damaged corneal nerves is formed of a conductive material and is attached between the upper left eye and the left eyebrow to transmit a stimulation signal.
- a multi-channel unit including a second channel formed of the conductive material and attached between the upper right eye and the right eyebrow to transmit the stimulation signal;
- a stimulation signal module providing a current pulse signal as the stimulation signal to the first channel and the second channel, wherein the multi-channel unit is integrally formed between the first channel and the second channel to provide the stimulation signal.
- the current pulse signal is a positive current pulse signal during a first duration, a current signal of 0 during a second duration that is next to the first duration, and the During a third duration following the second duration, a negative current pulse signal, during a fourth duration following the third duration, a current signal of 0, and a fifth duration following the fourth duration.
- a current signal of 0 during a sixth duration following the fifth duration, a positive current pulse signal during a seventh duration following the sixth duration, and the seventh During the eighth duration, which is next to the duration, a current signal of 0 is configured, the length of the first duration of the current pulse signal is 2 to 15 times the length of the third duration of the current pulse signal, and the current The length of the fifth duration of the pulse signal is characterized in that 2 to 15 times the length of the seventh duration of the current pulse signal.
- magnets are disposed on the contactor of the multi-channel unit and the stimulation signal module, respectively, so that the contactor and the stimulation signal module of the multi-channel unit When approaching within this predetermined range, the contactor of the multi-channel unit and the stimulation signal module may be self-aligned by the attractive force of the magnets respectively disposed.
- the current pulse when pressure is applied to the up button of the stimulation signal module, the current pulse is proportional to the number of times the pressure is applied to the up button.
- the magnitude of the current pulse signal when the magnitude of the signal is increased and pressure is applied to the down button of the stimulus signal module, the magnitude of the current pulse signal may be reduced in inverse proportion to the number of times the pressure is applied to the down button.
- the pulse width is proportional to the number of times the pressure is applied to the up button.
- the amplitude of the current pulse signal is controlled to increase, and when pressure is applied to the down button, the pulse width modulated signal is inversely proportional to the number of times the pressure is applied to the down button.
- the fourth duration of the current pulse signal may be 5 to 2000 times the second duration of the current pulse signal.
- the eighth duration of the current pulse signal may be 5 to 2000 times the sixth duration of the current pulse signal.
- the magnitude of the absolute value of the positive pulsed current signal of the first duration of the current pulse signal is the third duration of the current pulse signal Is equal to the magnitude of the absolute value of the negative pulse current signal
- the magnitude of the absolute value of the negative pulse current signal of the fifth duration of the current pulse signal is the positive pulse current of the seventh duration of the current pulse signal It can be the same as the magnitude of the absolute value of the signal.
- the magnitude of the absolute value of the positive pulsed current signal of the first duration of the current pulse signal is the third duration of the current pulse signal Is 2 to 15 times the magnitude of the absolute value of the negative pulse current signal
- the magnitude of the absolute value of the negative pulse current signal of the fifth duration of the current pulse signal is the amount of the seventh duration of the current pulse signal It may be 2 to 15 times the magnitude of the absolute value of the pulse current signal of.
- the current pulse signal may be in a charge-balanced state.
- the stimulation signal module receives the current pulse signal for the first duration and the current pulse signal for the seventh duration.
- a current pulse signal for the third duration and a current pulse signal for the fifth duration may be provided to the second channel.
- the multi-channel stimulation system for regenerating damaged corneal nerves is formed of a conductive material and is attached to the upper left eyebrow to transmit a stimulation signal, and the conductive A twelfth channel formed of a material and attached to the lower left eye to transmit the stimulation signal, a twenty-first channel made of the conductive material and attached to the upper right eyebrow to transmit the stimulation signal, and formed of the conductive material
- a multi-channel unit including a 22nd channel attached to the lower right eye and transmitting the stimulus signal;
- a stimulation signal module providing a current pulse signal as the stimulation signal to the eleventh channel, the 12th channel, the 21st channel, and the 22nd channel, wherein the multi-channel unit comprises the eleventh channel and the A contactor integrally formed between the 21 channels and electrically contacting the stimulus signal module, wherein the current pulse signal is a positive current pulse signal during a first duration, and a second second after the first duration A current signal of 0 during a duration, a negative current
- magnets are disposed on the contactor of the multi-channel unit and the stimulation signal module, respectively, so that the contactor and the stimulation signal module of the multi-channel unit When approaching within this predetermined range, the contactor of the multi-channel unit and the stimulation signal module may be self-aligned by the attractive force of the magnets respectively disposed.
- the current pulse when pressure is applied to the up button of the stimulation signal module, the current pulse is proportional to the number of times the pressure is applied to the up button.
- the magnitude of the current pulse signal when the magnitude of the signal is increased and pressure is applied to the down button of the stimulus signal module, the magnitude of the current pulse signal may be reduced in inverse proportion to the number of times the pressure is applied to the down button.
- the pulse width is proportional to the number of times the pressure is applied to the up button.
- the amplitude of the current pulse signal is controlled to increase, and when pressure is applied to the down button, the pulse width modulated signal is inversely proportional to the number of times the pressure is applied to the down button.
- the fourth duration of the current pulse signal may be 5 to 2000 times the second duration of the current pulse signal.
- the eighth duration of the current pulse signal may be 5 to 2000 times the sixth duration of the current pulse signal.
- the magnitude of the absolute value of the positive pulsed current signal of the first duration of the current pulse signal is the third duration of the current pulsed signal. Is equal to the magnitude of the absolute value of the negative pulse current signal, and the magnitude of the absolute value of the negative pulse current signal of the fifth duration of the current pulse signal is the positive pulse current of the seventh duration of the current pulse signal It can be the same as the magnitude of the absolute value of the signal.
- the magnitude of the absolute value of the positive pulsed current signal of the first duration of the current pulse signal is the third duration of the current pulsed signal. Is 2 to 15 times the magnitude of the absolute value of the negative pulse current signal, and the magnitude of the absolute value of the negative pulse current signal of the fifth duration of the current pulse signal is the amount of the seventh duration of the current pulse signal It may be 2 to 15 times the magnitude of the absolute value of the pulse current signal of.
- the current pulse signal may be in a charge-balanced state.
- the stimulation signal module receives the current pulse signal for the first duration and the current pulse signal for the seventh duration.
- a current pulse signal for the third duration and a current pulse signal for the fifth duration to the twelfth channel, and the current pulse signal for the first duration and the seventh duration A current pulse signal for a period of time may be provided to the 21st channel, and a current pulse signal for the third duration and a current pulse signal for the fifth duration may be provided to the 22nd channel.
- the multi-channel stimulation system for regeneration of damaged corneal nerves can effectively regenerate damaged corneal nerves by applying a current pulse signal as a stimulation signal through a multi-channel attached to a plurality of areas close to the eye. .
- FIG. 1 is a diagram showing a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention.
- FIG. 2 is a view showing a state in which a multi-channel unit of a multi-channel stimulation system for regenerating damaged corneal nerves according to an embodiment of the present invention is attached to a region close to a human eye.
- FIG. 3 is a view showing a state in which a multi-channel unit and a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention are attached to a region close to a human eye.
- FIG. 4 is a block diagram of a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention.
- FIG. 5 is a voltage control circuit diagram according to pressure recovery of an up button or a down button employed in a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention.
- FIG. 6 is a view showing a current pulse signal provided by a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention.
- FIG. 7 is a diagram showing a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention.
- FIG. 8 is a view showing a state in which a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention is attached to a region close to a human eye.
- FIG. 9 is a view showing a state in which a multi-channel unit and a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention are attached to a region close to a human eye.
- FIG. 10 is a block diagram of a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention.
- FIG. 11 is a voltage control circuit diagram according to pressure recovery of an up button or a down button employed in a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention.
- FIG. 12 is a diagram illustrating a current pulse signal provided by a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention.
- FIG. 13 is a photograph of measuring the degree of treatment of the epithelial cells of the damaged cornea after 0, 3 and 7 days elapse while being treated using a multi-channel stimulation system for regeneration of damaged corneal nerves according to embodiments of the present invention.
- FIG. 14 is a confocal view of the degree of regeneration of nerve cells in the damaged cornea after 1 week, 2 weeks and 4 weeks while treatment using a multi-channel stimulation system for regeneration of damaged corneal nerves according to embodiments of the present invention. ) Photo taken under a microscope.
- FIGS. 1 to 6 a multi-channel stimulation system for regenerating damaged corneal nerves according to an embodiment of the present invention will be described with reference to FIGS. 1 to 6.
- FIG. 1 is a diagram showing a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention
- FIG. 2 is a multi-channel unit for regeneration of damaged corneal nerves according to an embodiment of the present invention.
- FIG. 3 is a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention
- FIG. 4 is a block diagram of a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention.
- 5 is a voltage control circuit diagram according to pressure recovery of an up button or a down button employed in a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to an embodiment of the present invention, and
- the multi-channel unit 1100 of the multi-channel stimulation system for regeneration of damaged corneal nerves is formed of a conductive material and is attached between the upper left eye and the left eyebrow, as shown in FIGS. 1 and 2.
- a first channel 1110 for transmitting the stimulation signal a second channel 1120 formed of the conductive material and attached between the upper right eye and the right eyebrow to transmit the stimulation signal, and the first channel 1110
- the second channel 1120 and formed integrally with the contactor 1130 in electrical contact with the stimulation signal module 1200 may be formed of Ag, AgCl, Au, Pt, or stainless steel.
- the stimulation signal module 1200 provides a current pulse signal as the stimulation signal to the first channel 1110 and the second channel 1120, and as shown in FIG. 3, as if wearing goggles, a person
- the contactor 1130 and the stimulation signal module 1200 of the multi-channel unit 1100 may be worn between the eyes and the nose of the multi-channel unit 1100, respectively, a magnet is disposed to the contactor 1130 of the multi-channel unit 1100 )
- the stimulation signal module 1200 approaching within a predetermined range, the contactor 1130 and the stimulation signal module 1200 of the multi-channel unit 1100 by the attractive force of the magnets respectively disposed It is self-aligned.
- the above-described stimulation signal module 1200 includes stimulation signal providing units 1221 and 1222 for generating a current pulse signal, and a control unit for controlling the stimulation signal providing units 1221 and 1222 ( 1210), an up button 1231, a down button 1232, a communication unit 1240 communicating with the outside, and a charging unit 1250.
- the magnitude of the current pulse signal increases in proportion to the number of times the pressure is applied to the up button 1231, and the stimulation signal module
- the magnitude of the current pulse signal is reduced in inverse proportion to the number of times the pressure is applied to the down button 1232.
- the stimulation signal module 1200 when pressure is applied to the up button 1231, the stimulation signal module 1200 includes the number of pulses of the pulse width modulated signal PWM in proportion to the number of times the pressure is applied to the up button 1231.
- the pulse width modulated signal is inversely proportional to the number of times the pressure is applied to the down button 1232
- the current pulse signal is controlled to decrease in magnitude.
- the number of times the pressure is applied to the up button 1231 is three times, as shown in FIG. 5, three pulse width modulated signals PWM are transmitted to the transistor Q1 and thus three pulse widths are applied. Since the transistor Q1 is turned on during the modulation signal PWM, the voltage boosted by the inductor L1 is charged in the capacitors C2 and C3 in proportion to the amount of change in the current flowing during the three pulse width modulation signals PWM. . Therefore, since the voltage boosted in proportion to the number of pulse width modulated signals PWM is charged in the capacitors C2 and C3, the magnitude of the current pulse signal increases in proportion to the number of times the pressure is applied to the up button 1231. Conversely, the size of the current pulse signal may be reduced in inverse proportion to the number of times the pressure is applied to the down button 1232.
- the current pulse signal is a positive current pulse signal during a first duration (1D), and a current signal of zero during a second duration (2D) following the first duration (1D).
- the fourth duration (4D) of the current pulse signal is 5 to 2000 times the second duration (2D) of the current pulse signal
- the eighth duration (8D) of the current pulse signal is the current pulse signal. Is 5 to 2000 times of the sixth duration of (6D).
- the fourth duration (4D) of the current pulse signal is 25 ⁇ s to 10,000 ⁇ s
- the sixth duration of the current pulse signal is When the duration time 6D is 5 ⁇ s, the eighth duration time 8D of the current pulse signal is 25 ⁇ s to 10,000 ⁇ s.
- the magnitude (1A) of the absolute value of the positive pulsed current signal of the first duration (1D) of the current pulse signal is the absolute value of the negative pulsed current signal of the third duration (3D) of the current pulse signal Is equal to the magnitude (3A)
- the magnitude (5A) of the absolute value of the negative pulsed current signal of the fifth duration (5D) of the current pulse signal is the amount of the seventh duration (7D) of the current pulse signal Is equal to the magnitude of the absolute value of the pulsed current signal (7A).
- the magnitude (1A) of the absolute value of the positive pulsed current signal of the first duration (1D) of the current pulse signal is the absolute value of the negative pulsed current signal of the third duration (3D) of the current pulse signal
- the magnitude (5A) of the absolute value of the negative pulse current signal of the fifth duration (5D) of the current pulse signal is 2 to 15 times the magnitude (3A) of the current pulse signal (7D) ) Is 2 to 15 times the magnitude of the absolute value of the positive pulse current signal (7A).
- the first duration 1D The absolute value of the positive pulse current signal is composed of 2mA ⁇ 15mA, and the absolute value of the positive pulse current signal of the seventh duration (7D) is the same during the fifth duration (5D) and the seventh duration (7D).
- the absolute value of the negative pulse current signal of the fifth duration 5D is configured to be 2 mA to 15 mA, and the current pulse signal is configured to be in a charge-balanced state.
- the length of the first duration (1D) of the current pulse signal is the same as the length of the third duration (3D) of the current pulse signal, and the length of the fifth duration (5D) of the current pulse signal is It is equal to the length of the seventh duration 7D of the current pulse signal.
- the length of the first duration (1D) of the current pulse signal is 2 to 15 times the length of the third duration (3D) of the current pulse signal
- the fifth duration (5D) of the current pulse signal The length of is 2 to 15 times the length of the seventh duration 7D of the current pulse signal.
- the magnitude (1A) of the absolute value of the positive pulse current signal of the first duration (1D) and the magnitude (3A) of the negative pulse current signal of the third duration (3D) are the same,
- the first duration (1D) is composed of 20 ⁇ s to 300 ⁇ s, and the magnitude of the absolute value of the negative pulse current signal of the fifth duration (5D) (5A) and the fifth duration (5D) when the magnitude (7A) of the absolute value of the positive pulse current signal of the seventh duration (7D) is the same and the length of the seventh duration (7D) is 10 ⁇ s Is composed of 20 ⁇ s to 300 ⁇ s, and the current pulse signal is configured to be in a charge-balanced state.
- the stimulation signal module 1200 provides the current pulse signal for the first duration (1D) and the current pulse signal for the seventh duration (7D) to the first channel 1110, the A current pulse signal for a third duration 3D and a current pulse signal for the fifth duration 5D are provided to the second channel 1120.
- FIGS. 7 to 12 a multi-channel stimulation system for regenerating damaged corneal nerves according to another embodiment of the present invention will be described with reference to FIGS. 7 to 12.
- FIG. 7 is a diagram showing a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention
- FIG. 8 is a multi-channel unit for regeneration of damaged corneal nerves according to another embodiment of the present invention.
- FIG. 9 is a multi-channel unit of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention
- FIG. 10 is a block diagram of a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention.
- 11 is a voltage control circuit diagram according to pressure recovery of an up button or a down button employed in a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment of the present invention
- FIG. 12 is A diagram showing a current pulse signal provided by a stimulation signal module of a multi-channel stimulation system for regeneration of damaged corneal nerves according to another embodiment.
- the multi-channel unit 2100 of the multi-channel stimulation system for regenerating damaged corneal nerves is formed of a conductive material and is attached to the upper left eyebrow to transmit a stimulation signal as shown in FIGS. 7 and 8.
- the eleventh channel 2111, the twelfth channel 2112, the 21st channel 2121, the 22nd channel 2122 and the contactor 2130 are Ag, AgC
- the stimulation signal module 2200 provides a current pulse signal as the stimulation signal to the eleventh channel 2111, the 12th channel 2112, the 21st channel 2121, and the 22nd channel 2122. And, as shown in Figure 9, like wearing goggles, it can be worn between the eyes and nose of a person, the contactor 2130 of the multi-channel unit 2100 and the stimulation signal module 2200, respectively When a magnet is disposed so that the contactor 2130 of the multi-channel unit 2100 and the stimulation signal module 2200 approach within a predetermined range, the multi-channel unit ( The contactor 2130 of 2100 and the stimulus signal module 2200 are self-aligned.
- the stimulation signal module 2200 described above includes stimulation signal providing units 2221 and 2222 generating current pulse signals, and a control unit controlling the stimulation signal providing units 2221 and 2222 ( 2210), an up button 2231, a down button 2232, a communication unit 2240 communicating with the outside, and a charging unit 2250.
- the magnitude of the current pulse signal increases in proportion to the number of times the pressure is applied to the up button 2231, and the stimulation signal module
- the magnitude of the current pulse signal is reduced in inverse proportion to the number of times the pressure is applied to the down button 2232.
- the stimulation signal module 2200 is the number of pulses of the pulse width modulated signal PWM in proportion to the number of times the pressure is applied to the up button 2231 when pressure is applied to the up button 2231 By adjusting the pulse width modulated signal in inverse proportion to the number of times the pressure is applied to the down button 2232 when the pressure is applied to the down button 2232 and, when the pressure is applied to the down button 2232 By adjusting the number of pulses of (PWM), the current pulse signal is controlled to decrease in magnitude.
- the number of times the pressure is applied to the up button 2231 is three times, as shown in FIG. 11, three pulse width modulated signals PWM are transmitted to the transistor Q1 and thus three pulse widths are applied. Since the transistor Q1 is turned on during the modulation signal PWM, the voltage boosted by the inductor L1 is charged in the capacitors C2 and C3 in proportion to the amount of change in the current flowing during the three pulse width modulation signals PWM. . Therefore, since the voltage boosted in proportion to the number of pulse width modulated signals PWM is charged in the capacitors C2 and C3, the magnitude of the current pulse signal increases in proportion to the number of times the pressure is applied to the up button 2231. Conversely, it is possible to control the size of the current pulse signal to decrease in inverse proportion to the number of times the pressure is applied to the down button 2232.
- the current pulse signal is a positive current pulse signal during a first duration (1D), and a current signal of zero during a second duration (2D) following the first duration (1D).
- the fourth duration (4D) of the current pulse signal is 5 to 2000 times the second duration (2D) of the current pulse signal
- the eighth duration (8D) of the current pulse signal is the current pulse signal. Is 5 to 2000 times of the sixth duration of (6D).
- the fourth duration (4D) of the current pulse signal is 25 ⁇ s to 10,000 ⁇ s
- the sixth duration of the current pulse signal is When the duration time 6D is 5 ⁇ s, the eighth duration time 8D of the current pulse signal is 25 ⁇ s to 10,000 ⁇ s.
- the magnitude (1A) of the absolute value of the positive pulsed current signal of the first duration (1D) of the current pulse signal is the absolute value of the negative pulsed current signal of the third duration (3D) of the current pulse signal Is equal to the magnitude (3A)
- the magnitude (5A) of the absolute value of the negative pulsed current signal of the fifth duration (5D) of the current pulse signal is the amount of the seventh duration (7D) of the current pulse signal Is equal to the magnitude of the absolute value of the pulsed current signal (7A).
- the magnitude (1A) of the absolute value of the positive pulsed current signal of the first duration (1D) of the current pulse signal is the absolute value of the negative pulsed current signal of the third duration (3D) of the current pulse signal
- the magnitude (5A) of the absolute value of the negative pulse current signal of the fifth duration (5D) of the current pulse signal is 2 to 15 times the magnitude (3A) of the current pulse signal (7D) ) Is 2 to 15 times the magnitude of the absolute value of the positive pulse current signal (7A).
- the first duration 1D The absolute value of the positive pulse current signal is composed of 2mA ⁇ 15mA, and the absolute value of the positive pulse current signal of the seventh duration (7D) is the same during the fifth duration (5D) and the seventh duration (7D).
- the absolute value of the negative pulse current signal of the fifth duration 5D is configured to be 2 mA to 15 mA, and the current pulse signal is configured to be in a charge-balanced state.
- the length of the first duration (1D) of the current pulse signal is the same as the length of the third duration (3D) of the current pulse signal, and the length of the fifth duration (5D) of the current pulse signal is It is equal to the length of the seventh duration 7D of the current pulse signal.
- the length of the first duration (1D) of the current pulse signal is 2 to 15 times the length of the third duration (3D) of the current pulse signal
- the fifth duration (5D) of the current pulse signal The length of is 2 to 15 times the length of the seventh duration 7D of the current pulse signal.
- the magnitude (1A) of the absolute value of the positive pulse current signal of the first duration (1D) and the magnitude (3A) of the negative pulse current signal of the third duration (3D) are the same,
- the first duration (1D) is composed of 20 ⁇ s to 300 ⁇ s, and the magnitude of the absolute value of the negative pulse current signal of the fifth duration (5D) (5A) and the fifth duration (5D) when the magnitude (7A) of the absolute value of the positive pulse current signal of the seventh duration (7D) is the same and the length of the seventh duration (7D) is 10 ⁇ s Is composed of 20 ⁇ s to 300 ⁇ s, and the current pulse signal is configured to be in a charge-balanced state.
- the stimulation signal module 2200 provides a current pulse signal for the first duration (1D) and a current pulse signal for the seventh duration (7D) to the eleventh channel (2111), and the A current pulse signal for a third duration (3D) and a current pulse signal for the fifth duration (5D) are provided to the twelfth channel (2112), and a current pulse during the first duration (1D) A signal and a current pulse signal for the seventh duration (7D) are provided to the twenty-first channel (2121), and the current pulse signal for the third duration (3D) and the fifth duration (5D) A current pulse signal of is provided to the 22nd channel 2122. That is, the stimulation signal module 2200 provides the same current pulse signal to the eleventh channel 2111 and the 21st channel 2121, and the same current pulse signal to the 12th channel 2112 and the 22nd channel 2122. Provides.
- FIG. 13 is a photograph of measuring the degree of treatment of the epithelial cells of the damaged cornea after 0, 3 and 7 days elapse while being treated using a multi-channel stimulation system for regeneration of damaged corneal nerves according to embodiments of the present invention.
- the control group measured the damaged cornea after receiving normal treatment (e.g., antibiotic administration) to the cornea of a patient who had undergone vision correction surgery to cut a part of the cornea, and the first protocol experimental group cut a part of the cornea.
- normal treatment e.g., antibiotic administration
- a current pulse signal of 20 Hz is used using a multi-channel stimulation system for regeneration of damaged corneal nerves according to embodiments of the present invention.
- the damaged cornea was measured while treating the damaged corneal nerve, and in the second protocol experimental group, in addition to the usual treatment (e.g., administration of antibiotics) to the cornea of a patient who had undergone vision correction to cut a part of the cornea, examples of the present invention
- the damaged cornea was measured while treating the damaged corneal nerve with a current pulse signal of 2 Hz using a multi-channel stimulation system for regeneration of the damaged corneal nerve according to.
- FIG. 14 is a confocal view of the degree of regeneration of nerve cells in the damaged cornea after 7 days, 14 days and 28 days while treatment using a multi-channel stimulation system for regeneration of damaged corneal nerves according to embodiments of the present invention.
- This is a picture measured with a microscope.
- the control group measured the degree of regeneration of nerve cells in the damaged cornea after receiving normal treatment (e.g., antibiotic administration) to the cornea of a patient who had undergone vision correction by cutting a part of the cornea.
- normal treatment e.g., antibiotic administration
- the damaged corneal nerve is treated using a multi-channel stimulation system for regeneration of the damaged corneal nerve according to the embodiments of the present invention.
- the degree of regeneration of nerve cells in the damaged cornea was measured.
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Abstract
Description
Claims (22)
- 도전성 물질로 형성되며 좌측 눈 상부와 좌측 눈썹 사이에 부착되어 자극 신호를 전달하는 제 1 채널과, 상기 도전성 물질로 형성되며 우측 눈 상부와 우측 눈썹 사이에 부착되어 상기 자극 신호를 전달하는 제 2 채널을 포함하는 멀티 채널 유닛; 및상기 제 1 채널과 상기 제 2 채널에 상기 자극 신호로 전류 펄스 신호를 제공하는 자극 신호 모듈을 포함하며,상기 멀티 채널 유닛은 상기 제 1 채널과 상기 제 2 채널 사이에 일체로 형성되어 상기 자극 신호 모듈에 전기적으로 접촉되는 컨택터를 포함하며,상기 전류 펄스 신호는 제 1 지속 시간 동안에는 양의 전류 펄스 신호이고, 상기 제 1 지속 시간의 다음인 제 2 지속 시간 동안에는 0의 전류 신호이며, 상기 제 2 지속 시간의 다음인 제 3 지속 시간 동안에는 음의 전류 펄스 신호이고, 상기 제 3 지속 시간의 다음인 제 4 지속 시간 동안에는 0의 전류 신호이며, 상기 제 4 지속 시간의 다음인 제 5 지속 시간 동안에는 음의 전류 펄스 신호이고, 상기 제 5 지속 시간의 다음인 제 6 지속 시간 동안에는 0의 전류 신호이며, 상기 제 6 지속 시간의 다음인 제 7 지속 시간 동안에는 양의 전류 펄스 신호이고, 상기 제 7 지속 시간의 다음인 제 8 지속 시간 동안에는 0의 전류 신호로 구성되고,상기 전류 펄스 신호의 제 1 지속 시간의 길이는 상기 전류 펄스 신호의 제 3 지속 시간의 길이의 2배 ~ 15배이고, 상기 전류 펄스 신호의 제 5 지속 시간의 길이는 상기 전류 펄스 신호의 제 7 지속 시간의 길이의 2배 ~ 15배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 멀티 채널 유닛의 컨택터와 상기 자극 신호 모듈은 각각 자석이 배치되어 상기 멀티 채널 유닛의 컨택터와 상기 자극 신호 모듈이 소정의 범위 내로 접근하는 경우에, 상기 각각 배치되어 있는 자석의 인력에 의해서 상기 멀티 채널 유닛의 컨택터와 상기 자극 신호 모듈이 셀프 얼라인되는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 자극 신호 모듈의 업 버튼에 압력이 가해지는 경우에, 상기 업 버튼에 압력이 가해지는 회수에 비례해서 상기 전류 펄스 신호의 크기가 증가되고, 상기 자극 신호 모듈의 다운 버튼에 압력이 가해지는 경우에, 상기 다운 버튼에 압력이 가해지는 회수에 반비례해서 상기 전류 펄스 신호의 크기가 감소되는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 3에 있어서,상기 자극 신호 모듈은 상기 업 버튼에 압력이 가해지는 경우에, 상기 업 버튼에 압력이 가해지는 회수에 비례해서 펄스 폭 변조 신호의 펄스 개수를 조절함으로써, 상기 전류 펄스 신호의 크기가 증가되도록 제어하고, 상기 다운 버튼에 압력이 가해지는 경우에, 상기 다운 버튼에 압력이 가해지는 회수에 반비례해서 상기 펄스 폭 변조 신호의 펄스 개수를 조절함으로써, 상기 전류 펄스 신호의 크기가 감소되도록 제어하는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 전류 펄스 신호의 제 4 지속 시간은 상기 전류 펄스 신호의 제 2 지속 시간의 5배 ~ 2000배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 전류 펄스 신호의 제 8 지속 시간은 상기 전류 펄스 신호의 제 6 지속 시간의 5배 ~ 2000배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 전류 펄스 신호의 제 1 지속 시간의 양의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 3 지속 시간의 음의 펄스 전류 신호의 절대값의 크기와 동일하고, 상기 전류 펄스 신호의 제 5 지속 시간의 음의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 7 지속 시간의 양의 펄스 전류 신호의 절대값의 크기와 동일한 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 전류 펄스 신호의 제 1 지속 시간의 양의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 3 지속 시간의 음의 펄스 전류 신호의 절대값의 크기의 2배 ~ 15배이고, 상기 전류 펄스 신호의 제 5 지속 시간의 음의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 7 지속 시간의 양의 펄스 전류 신호의 절대값의 크기의 2배 ~ 15배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 8에 있어서,상기 전류 펄스 신호는 전하 균형 상태(charge-balanced)인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 전류 펄스 신호는 전하 균형 상태(charge-balanced)인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 1에 있어서,상기 자극 신호 모듈은 상기 제 1 지속 시간 동안의 전류 펄스 신호와 상기 제 7 지속 시간 동안의 전류 펄스 신호를 상기 제 1 채널로 제공하고, 상기 제 3 지속 시간 동안의 전류 펄스 신호와 상기 제 5 지속 시간 동안의 전류 펄스 신호를 상기 제 2 채널로 제공하는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 도전성 물질로 형성되며 좌측 눈썹 상부에 부착되어 자극 신호를 전달하는 제 11 채널과, 상기 도전성 물질로 형성되며 좌측 눈 하부에 부착되어 상기 자극 신호를 전달하는 제 12 채널과, 상기 도전성 물질로 형성되며 우측 눈썹 상부에 부착되어 상기 자극 신호를 전달하는 제 21 채널과, 상기 도전성 물질로 형성되며 우측 눈 하부에 부착되어 상기 자극 신호를 전달하는 제 22 채널을 포함하는 멀티 채널 유닛; 및상기 제 11 채널, 상기 제 12 채널, 상기 제 21 채널 및 상기 제 22 채널에 상기 자극 신호로 전류 펄스 신호를 제공하는 자극 신호 모듈을 포함하며,상기 멀티 채널 유닛은 상기 제 11 채널과 상기 제 21 채널 사이에 일체로 형성되어 상기 자극 신호 모듈에 전기적으로 접촉되는 컨택터를 포함하며,상기 전류 펄스 신호는 제 1 지속 시간 동안에는 양의 전류 펄스 신호이고, 상기 제 1 지속 시간의 다음인 제 2 지속 시간 동안에는 0의 전류 신호이며, 상기 제 2 지속 시간의 다음인 제 3 지속 시간 동안에는 음의 전류 펄스 신호이고, 상기 제 3 지속 시간의 다음인 제 4 지속 시간 동안에는 0의 전류 신호이며, 상기 제 4 지속 시간의 다음인 제 5 지속 시간 동안에는 음의 전류 펄스 신호이고, 상기 제 5 지속 시간의 다음인 제 6 지속 시간 동안에는 0의 전류 신호이며, 상기 제 6 지속 시간의 다음인 제 7 지속 시간 동안에는 양의 전류 펄스 신호이고, 상기 제 7 지속 시간의 다음인 제 8 지속 시간 동안에는 0의 전류 신호로 구성되고,상기 전류 펄스 신호의 제 1 지속 시간의 길이는 상기 전류 펄스 신호의 제 3 지속 시간의 길이의 2배 ~ 15배이고, 상기 전류 펄스 신호의 제 5 지속 시간의 길이는 상기 전류 펄스 신호의 제 7 지속 시간의 길이의 2배 ~ 15배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 멀티 채널 유닛의 컨택터와 상기 자극 신호 모듈은 각각 자석이 배치되어 상기 멀티 채널 유닛의 컨택터와 상기 자극 신호 모듈이 소정의 범위 내로 접근하는 경우에, 상기 각각 배치되어 있는 자석의 인력에 의해서 상기 멀티 채널 유닛의 컨택터와 상기 자극 신호 모듈이 셀프 얼라인되는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 자극 신호 모듈의 업 버튼에 압력이 가해지는 경우에, 상기 업 버튼에 압력이 가해지는 회수에 비례해서 상기 전류 펄스 신호의 크기가 증가되고, 상기 자극 신호 모듈의 다운 버튼에 압력이 가해지는 경우에, 상기 다운 버튼에 압력이 가해지는 회수에 반비례해서 상기 전류 펄스 신호의 크기가 감소되는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 14에 있어서,상기 자극 신호 모듈은 상기 업 버튼에 압력이 가해지는 경우에, 상기 업 버튼에 압력이 가해지는 회수에 비례해서 펄스 폭 변조 신호의 펄스 개수를 조절함으로써, 상기 전류 펄스 신호의 크기가 증가되도록 제어하고, 상기 다운 버튼에 압력이 가해지는 경우에, 상기 다운 버튼에 압력이 가해지는 회수에 반비례해서 상기 펄스 폭 변조 신호의 펄스 개수를 조절함으로써, 상기 전류 펄스 신호의 크기가 감소되도록 제어하는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 전류 펄스 신호의 제 4 지속 시간은 상기 전류 펄스 신호의 제 2 지속 시간의 5배 ~ 2000배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 전류 펄스 신호의 제 8 지속 시간은 상기 전류 펄스 신호의 제 6 지속 시간의 5배 ~ 2000배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 전류 펄스 신호의 제 1 지속 시간의 양의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 3 지속 시간의 음의 펄스 전류 신호의 절대값의 크기와 동일하고, 상기 전류 펄스 신호의 제 5 지속 시간의 음의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 7 지속 시간의 양의 펄스 전류 신호의 절대값의 크기와 동일한 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 전류 펄스 신호의 제 1 지속 시간의 양의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 3 지속 시간의 음의 펄스 전류 신호의 절대값의 크기의 2배 ~ 15배이고, 상기 전류 펄스 신호의 제 5 지속 시간의 음의 펄스 전류 신호의 절대값의 크기는 상기 전류 펄스 신호의 제 7 지속 시간의 양의 펄스 전류 신호의 절대값의 크기의 2배 ~ 15배인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 19에 있어서,상기 전류 펄스 신호는 전하 균형 상태(charge-balanced)인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 전류 펄스 신호는 전하 균형 상태(charge-balanced)인 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
- 청구항 12에 있어서,상기 자극 신호 모듈은 상기 제 1 지속 시간 동안의 전류 펄스 신호와 상기 제 7 지속 시간 동안의 전류 펄스 신호를 상기 제 11 채널로 제공하고, 상기 제 3 지속 시간 동안의 전류 펄스 신호와 상기 제 5 지속 시간 동안의 전류 펄스 신호를 상기 제 12 채널로 제공하며, 상기 제 1 지속 시간 동안의 전류 펄스 신호와 상기 제 7 지속 시간 동안의 전류 펄스 신호를 상기 제 21 채널로 제공하고, 상기 제 3 지속 시간 동안의 전류 펄스 신호와 상기 제 5 지속 시간 동안의 전류 펄스 신호를 상기 제 22 채널로 제공하는 손상된 각막 신경 재생을 위한 멀티 채널 자극 시스템.
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