WO2020196818A1 - Système et procédé de formation de culture cellulaire - Google Patents

Système et procédé de formation de culture cellulaire Download PDF

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Publication number
WO2020196818A1
WO2020196818A1 PCT/JP2020/013940 JP2020013940W WO2020196818A1 WO 2020196818 A1 WO2020196818 A1 WO 2020196818A1 JP 2020013940 W JP2020013940 W JP 2020013940W WO 2020196818 A1 WO2020196818 A1 WO 2020196818A1
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Prior art keywords
subject
posture
protocol
movement
training
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PCT/JP2020/013940
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English (en)
Japanese (ja)
Inventor
秀輝 種村
幸司 小出
モハマッド ガジザデ
泰寛 能勢
陽一朗 西野
千草 下川
真帆 今井
闊 陳
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株式会社バイオミメティクスシンパシーズ
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Priority claimed from JP2020053979A external-priority patent/JP2020166264A/ja
Application filed by 株式会社バイオミメティクスシンパシーズ filed Critical 株式会社バイオミメティクスシンパシーズ
Publication of WO2020196818A1 publication Critical patent/WO2020196818A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B19/00—Teaching not covered by other main groups of this subclass
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B9/00—Simulators for teaching or training purposes

Definitions

  • the present invention relates to an education system and an education method for acquiring and mastering a technique related to stem cell culture, and particularly to an education system and an education method to which a virtual reality (VR) technique is applied.
  • VR virtual reality
  • xR augmented reality
  • MR mixed reality
  • the clean room is a limited space, it is difficult to practice various operations in cell isolation and culturing due to the capacity of the clean room.
  • the clean room is a limited space, and the work in the clean room, which is a limited space, is limited to 3 hours due to the relationship between tension and continuous concentration. Therefore, it is difficult to practice the work performed in the clean room for 3 hours or more due to the relationship between the trainee's tension and the maintenance of concentration.
  • various operations in cell isolation and culturing required training for at least about 6 months. However, it is difficult to accept a large number of trainees because a small number of skilled workers need to teach individual trainees on a so-called “one-to-one” basis.
  • the present invention has been proposed in view of the above-mentioned problems of the prior art, and an object of the present invention is to provide a system and a method for acquiring and mastering a technique related to stem cell culture by applying virtual reality (VR) technique. There is.
  • VR virtual reality
  • the cell culture education system (100) of the present invention Measuring device (10: glove 1, goggles 2, camera 3, etc.) and control device for measuring the state (position, posture, movement, etc. of subject E's hand) of the subject (E: inexperienced in stem cell culture technology)
  • the control device (20) includes (20: control unit CU). From the information from the measuring device (10), the data of the position, posture, and movement of the subject (E) (used to include not only the simple movement but also the work sequence and procedure) is calculated and created, and the image (used.
  • Avatar, alter ego image) calculation and creation function A function to display the image of the subject (E) in virtual reality (VR), From the data (position, posture, movement) based on the protocol of the technology related to stem cell culture, the subject (E) was modified according to (height, age, gender, etc.), and the subject (E) followed the protocol.
  • a function to create data position, posture, motion data: including video) by calculating the position, posture, and motion of the case, It is characterized by having a function of comparing the position, posture, and movement of the subject (E) with the data (position, posture, movement) according to the protocol (in virtual reality or between data).
  • VR virtual reality
  • AR augmented reality
  • VR virtual reality
  • equipment necessary for cell culture for example, clean bench, incubator, etc.
  • instruments for example, flasks, pipettes, etc.
  • reagents for example, microscopes, and other necessary articles. Necessary for everything.
  • AR augmented reality
  • VR virtual reality
  • the real thing can be used for various devices and articles.
  • the control device (20) conforms to the position, posture, movement (or image calculated and created based on the data) of the subject (E), and the protocol. It has a function to warn the subject (E) by stopping the image displayed in virtual reality, for example, when there is a large difference in data (position, posture, movement: or calculation, created image). It is preferable to have it. Further, in the cell culture education system (100) of the present invention, the control device (20) reproduces a work procedure as a model moving image (a moving image showing a model work; a moving image as a model), character information, and voice information. It is preferable to have a function of executing a mode (mode) (scenario mode), a mode (simulation mode) for practicing the subject (E), and a mode (trial mode) for evaluating the subject (E).
  • mode mode
  • the cell culture education method of the present invention A measuring device (10: glove 1, goggles 2, camera 3, etc.) and a control device (10: glove 1, goggles 2, camera 3, etc.) for measuring the state (position, posture, movement of the subject E's hand) of the subject (E: inexperienced in technology related to stem cell culture) 20: Using the system including the control unit CU) (100: the system of claims 1 and 2), The position, posture, and motion data of the subject (E) are calculated and created from the information from the measuring device (10), and the image (avatar, alter ego image) is calculated and created.
  • the image of the subject (E) is displayed in virtual reality (VR), From the data (position, posture, movement) based on the protocol of the technology related to stem cell culture, it is modified according to the subject (E) (height, age, gender, etc.), and the position when the subject follows the protocol.
  • Posture, motion is calculated to create data (position, posture, motion, etc.), It is characterized by comparing the position, posture, and movement of the subject (E) with the data (position, posture, movement) according to the protocol (in virtual reality or between data).
  • the position, posture, and movement of the subject (E) (or an image calculated and created based on the data) and data according to the protocol (position, posture, movement: or calculation,
  • the protocol position, posture, movement: or calculation
  • various techniques (work or operation) related to cell culture include cell isolation, cell culture (for example, subculture work), wearing gouning (dedicated clothes), washing after wearing, entering and exiting a clean room, and the like. It includes various contents in hygiene control department education, manufacturing control department education, and quality control department education.
  • a mode in which a work procedure is reproduced by a model moving image (a moving image showing a model work; a moving image as a model), text information, and voice information, and a subject. It is preferable to have a step of selecting either the mode for practicing (E) (simulation mode) or the mode for evaluating the subject (E) (trial mode).
  • stem cell culture various contents in hygiene management department education, manufacturing management department education, quality control department education
  • VR virtual reality
  • facilities can be used for training, so the ability to perform necessary processing can be improved. Since it is not necessary to use an actual living body (human body) or facility, there is no limitation on the place where training or education is performed, and it is possible to remove the limitation on the time for training or education. Further, since it is not necessary for the expert to accompany each trainee (subject E) on a one-to-one basis, the time burden on the expert who is insufficient in number is reduced.
  • the training is performed by virtual reality, even if an inexperienced trainee makes a mistake, a serious situation does not occur. Therefore, it does not give excessive tension to immature trainees. Then, since the content of the failure can be recorded and checked by the person who made the failure, the cause of the failure can be analyzed accurately and calmly.
  • the so-called "quality of education” can be made uniform with respect to cell culture without any variation in educational results due to differences in teaching skills and educational skills among individual leaders and experts.
  • the cell culture engineer can be efficiently educated, the time required for the education of the cell culture technology is not prolonged, and it is not necessary to increase the place or equipment required for the education. (For example, the time of a skilled person must be spent for the education of beginners) can be reduced, which is advantageous in performing cell culture as a business.
  • the work is strictly defined according to a strictly defined protocol for cell culture, for example, when cell isolation occurs, not only the tissue from which the cell was isolated but also the isolated cell is damaged. Will not be given. Therefore, it is prevented that the isolated cells are damaged and cannot be cultured.
  • the fluctuation for each case is small, and in many cases the same movement is performed in the same procedure. You can expect good skill.
  • SOP Standard Operation Program
  • the present invention since it is possible to become proficient in the work according to the strictly defined protocol, contamination by foreign substances (contamination by foreign substances) when a person who has received the education (training) of the present invention carries out the cell culture process ( Contamination) is less likely to occur. Then, if necessary, training using virtual reality for various tasks in the clean room, such as wearing downing (special clothes), cleaning after wearing, procedures for entering the clean room, and procedures for exiting the clean room. Can be done, further reducing the possibility of contamination. In addition, it is possible to improve the quality of engineers by providing high-quality education (or training) for all of the various contents in hygiene management department education, manufacturing control department education, and quality control department education.
  • a mode (mode) (scenario mode) in which a work procedure is reproduced by a model moving image (a moving image showing a model work; a model moving image), text information, and voice information, and a subject
  • mode scenario mode
  • a model moving image a moving image showing a model work; a model moving image
  • text information a subject
  • voice information a subject
  • a mode for practicing E simulation mode
  • the mode for evaluating the subject (E) (trial mode) it is efficient according to the proficiency level of the subject (E).
  • the cell culture education system according to the embodiment is indicated by reference numeral 100 as a whole, and is in a state of subject E (an unskilled person who receives education in the system according to the embodiment) (for example, the hand of subject E). It has a measuring device 10 (in the example of FIG. 1, a glove 1, goggles 2, a camera 3) and a control device 20 (control unit) for measuring a position, an attitude, an operation, etc.).
  • a measuring device 10 in the example of FIG. 1, a glove 1, goggles 2, a camera 3
  • control device 20 control unit for measuring a position, an attitude, an operation, etc.
  • the measuring device 10 includes gloves 1 (left-handed gloves 1A, right-handed gloves 1B), goggles 2, and a camera 3 worn by subject E during training (during attendance) by the system 100, and includes gloves 1A, 1B, and goggles. 2.
  • the camera 3 is connected to the control unit 20 via signal lines SL1-1A, SL1-1B, SL1-2, and SL1-3, respectively.
  • Information on the position and movement of the hand of subject E is input to the control unit 20 from the gloves 1A and 1B, and information on the position of the face of subject E, the direction in which the subject is facing, the movement, the direction of the line of sight, etc. is input from the goggles 2. It is input to the control 20.
  • the camera 3 captures the position, posture, and movement of the whole body of the subject E, and the information (information on the position, posture, and movement of the whole body of the subject E: including video or video) is input to the control unit 20.
  • the cell culture education system 100 has a display device 4 (monitor), and the display device 4 is connected to the control unit 20 via the signal line SL18.
  • the signal lines SL1-1A, SL1-1B, SL1-2, and SL1-3 may be wired or wireless.
  • the control unit 20 acquires information on the position (for example, the position of the hand), the posture, the movement, and the like of the subject E under training from the gloves 1 (1A, 1B), the goggles 2, the camera 3, and the like of the measuring device 10. Then, the avatar (image, alter ego image) on VR (virtual reality) is calculated and created. Then, the control unit 20 transmits the avatar of the subject E to the goggles 2 by the signal line SL1-2, and displays the avatar on the VR. At the same time, the avatar of the subject E is transmitted to the display device 4 via the signal line SL18, and the avatar of the subject E is displayed on the VR displayed by the display device 4. In FIG.
  • a VR that is, a virtual reality moving image or video that subject E is experiencing
  • the VR is the position, posture, and whole body of subject E's hand.
  • This is a VR related to the movement of the subject E, which is visually recognized and experienced by the subject E with the goggles 2.
  • the VR in reference numeral A is also displayed on the display device 4 for reference by the supervisor, the instructor, and the like.
  • an image of the work of isolating adipose tissue is shown in the range shown by region A.
  • the adipose tissue is aspirated or partially excised by surgery in a medical institution and brought into a cell culture institution (CPC: not shown) in a syringe-like or examiner-like container.
  • CPC cell culture institution
  • the stem cells are then isolated using a device such as a reagent or a centrifuge.
  • a video of the work of isolating subcutaneous fat from the human body H using a syringe-shaped instrument T is shown in the region A of FIG.
  • the stem cell culturing operation is performed in a so-called "clean bench” and is displayed in VR or AR to reproduce the operation in the green bench.
  • the avatar of the hand (glove 1A, 1B) of the subject E in VR is displayed.
  • control unit 20 see FIG. 2 of the control unit 20 (control device: see FIG. 2)
  • reference positions for example, hand positions, etc.
  • postures, movements, etc. are previously set for each of various cell culture operations. It is saved as data (including video).
  • data including video
  • the correct position, posture, movement, etc. model position, posture, movement, etc.
  • various operations of cell culture include cell isolation, cell culture, wearing gouning, washing washing, entering and exiting a clean room, and the like, and cell isolation and cell culture are further divided into multiple steps. Exists.
  • Data position, posture, movement, etc.
  • various work protocols related to cell culture stored in the database 20K are appropriately modified according to the height, age, gender, etc. of subject E and are displayed on VR. Is displayed in.
  • Data position, posture, movement, etc.
  • Data is created by calculating the corrected position, posture, movement, etc. when subject E follows the protocol, and an image (video, moving image) is further created, and the display device 4 Is displayed in VR.
  • Data such as height, age, and gender of subject E are input to the control unit 20 via the input device 5 prior to the education (training).
  • the structure of the program (the structure of the movements constituting the work), the cell culture protocol, the above-mentioned various equipments and instruments (flasks, etc.) used in the training, and the structure and structure.
  • Performance, etc. vary depending on the company or institution that performs cell culture. In the illustrated embodiment, such differences between companies and institutions are dealt with, and customization is made for each company and institution.
  • various equipment, instruments, reagents, materials, etc. are reproduced in actual size, and subject E is equivalent to the actual work. You can get a sense.
  • the data in the virtual reality such as the customized training contents, various equipments and instruments used are stored in the database 20K of the control device 20 (FIGS. 1 and 2) (FIG. 2), and correspond to the protocol and the like. It is configured to be selected and referenced. For example, with respect to equipment, appliances, etc., a plurality of types having different sizes are prepared in virtual reality, and a full-scale VR image corresponding to actual work exists in virtual reality.
  • the position, posture, movement, etc. of the subject E on the VR are compared with the position, posture, movement, etc. according to the protocol, and the difference between the two is obtained. .. Then, it is confirmed whether or not the difference is within the permissible range, and the result of the education is evaluated (for example, pass / fail is determined).
  • the difference between the two is large, not only the judgment of failure is made, but also, for example, the image displayed on the VR is stopped and a warning is given to the subject E on the VR or via the display device 4. Perform necessary processing according to the educational program, such as issuing. As a result, education or training of various movements related to cell culture is performed.
  • the “scenario mode” is a mode (aspect) for teaching subject E by displaying a video showing a model work, that is, a VR video as a model, or playing back a work procedure as text information or voice information.
  • the subject E is a beginner.
  • subject E learns by watching a video or work procedure showing a model work as text information or listening to it as audio information, and subject E performs a work operation in virtual reality. I don't do it.
  • the "simulation mode” is a mode in which the subject E wears the measuring device 10 (left-handed glove 1A, right-handed glove 1B, goggles 2) and performs a work operation or practices in virtual reality. Basically, subjects E who have experienced the scenario mode and can understand the work procedure to some extent are targeted.
  • the subject E can execute the training while receiving the work instruction (work instruction scenario guide) by voice or the like during the training (during the work operation).
  • work instruction scenario guide work instruction scenario guide
  • the "trial mode” is a mode in which the subject E wears the measuring device 10 (left-handed glove 1A, right-handed glove 1B, goggles 2) and performs the work operation to the end in virtual reality (in principle, it is not interrupted in the middle). , This is an aspect for confirming work proficiency.
  • the subject E who has experienced the scenario mode and the simulation mode is basically targeted.
  • pass / fail judgment and score evaluation are performed by comparing with the position, posture, movement, etc. according to the protocol.
  • the input device 5 has a mode switching block 5A having a function of selecting a mode, and when performing training, the subject E selects one of the three modes via the input device 5. You can choose.
  • a person other than the subject E can select the mode by the input device 5.
  • the selection or switching of "scenario mode”, “simulation mode”, and “trial mode” in the training, the contents and procedures of each mode, and the like will be described later with reference to FIG. 7.
  • the education (training, learning) carried out in the illustrated embodiment is aimed at acquiring and mastering the technique related to stem cell culture, and the data according to the protocol related to stem cell culture (position so as to serve as a model). (Including data such as posture, movement, and image) is set.
  • the protocol related to stem cell culture includes data such as posture, movement, and image.
  • the cells are isolated from fat, umbilical cord, umbilical cord blood and the like.
  • the cells are isolated around the capillaries, which can cause significant damage to both the isolated cells and (a part of) the human body from which the cells are isolated. It is necessary to take great care to isolate cells from around the capillaries so that they do not.
  • a strict protocol is defined so that it is possible to carry out the work in substantially the same procedure even if there are individual differences, and thus the risk is reduced. Therefore, as compared with surgery and the like, the movements and the like according to the protocol in various operations are made uniform according to the same procedure. Therefore, when creating virtual reality (VR), it is sufficient to create it according to SOP (Standard Operation Program).
  • VR virtual reality
  • SOP Standard Operation Program
  • the main purpose is to master uniform movements and the like according to the same procedure, so training using virtual reality is efficient.
  • Various operations related to cell culture include operations for culturing cells.
  • the operation according to the protocol is calculated and created so that the cultured cells are not completely destroyed due to contamination by foreign substances, for example.
  • training using virtual reality is also provided for wearing gouning (special clothing), cleaning after wearing, procedures for entering and exiting the clean room. Is executed. Since the clean room is a limited space here, the above-mentioned work training is limited by the capacity of the cleaning room. However, training using virtual reality does not require the use of an actual clean room and is not limited by the capacity of the clean room. And even in an open space, it is possible to train.
  • the clean room is a limited space, and work in the clean room is limited to 3 hours due to the relationship between tension and concentration. Along with that, the work in the clean room cannot be performed for more than 3 hours.
  • various tasks related to cell culture have conventionally required that each trainee be accompanied by a skilled person on a one-to-one basis. Therefore, the skilled workers, who are short of people, have taken time to give guidance to inexperienced people in addition to the work that should be done.
  • FIG. 2 which shows the functional blocks of the control unit 20 (control device) in the cell culture education system 100
  • the control unit 20 is surrounded by a broken line, and the subject position determination block 20A, the avatar creation block 20B, and the program determination block are shown.
  • It has 20C, correction block 20D, rule protocol position determination block 20E, rule protocol image creation block 20F, comparison block 20G, procedure pass / fail judgment block 20H, display video determination block 20I, video creation block 20J, and database 20K.
  • the phrase “determine the position or the like of the rule protocol” in the block 20E means “determine the position or the like according to the program”.
  • the wording "rule protocol image creation" on the block 20F means “creating an image according to a program”.
  • the subject position determination block 20A includes a glove 1 (left hand glove 1A, right hand glove 1B) worn by subject E (FIG. 1), goggles 2, and a position of subject E from the camera 3 (for example, the position of a hand). It has a function of acquiring information on posture, movement (state of subject E), etc. via the signal line SL1 and determining the real-time position, posture, movement, etc. of the hand of subject E, etc.
  • the reference numeral "SL1" is an expression including the signal lines SL1-1A, SL1-1B, SL1-2, and SL1-3 in FIG.
  • Data such as the position, posture, and motion of the subject E determined by the subject position determination block 20A are transmitted to the avatar creation block 20B via the signal line SL2.
  • the avatar creation block 20B has a function of calculating and creating an avatar (video, image, alter ego image) on VR based on data such as the position, posture, and motion of subject E acquired from the subject position determination block 20A. ..
  • the calculation and the function to be created are executed by applying a conventionally known technique.
  • the image (avatar) created by the avatar creation block 20B is transmitted to the comparison block 20G via the signal line SL3 and is transmitted to the moving image creation block 20J via the signal line SL4.
  • the moving image creation block 20J has a function of creating a working image of the subject E on the VR based on the data of the image (avatar) acquired from the avatar creation block 20B.
  • the data of the work image of the subject E created by the moving image creation block 20J is transmitted to the goggles 2 worn by the subject E via the signal line SL1-2, and the subject E displays the displayed image on the VR by the goggles 2. Visualize as an image.
  • the data signal of the work image of the subject E created by the moving image creation block 20J is transmitted to the display device 4 (monitor) via the signal line SL18, and the display device 4 is an image in which the avatar or the like is displayed on the VR. Is displayed.
  • a person other than the subject E for example, an instructor
  • the other functions of the moving image creation block 20J will be described in detail later.
  • the educator inputs the type of education (training) related to cell culture via the input device 5.
  • the program determination block 20C has a function of determining a target program corresponding to the input type of education.
  • Types of education (training) include, for example, cell isolation, cell culture, wearing gouning, washing washing, entering and exiting a clean room, and the like. Regarding cell isolation and cell culture, the content of training may be divided into multiple stages.
  • the correct position for example, hand position
  • the correct (worker's) position, posture, movement, etc. according to the protocol are stored in the database 20K.
  • the type (information) of the target program determined by the program determination block 20C is transmitted to the database 20K via the signal line SL6 and also transmitted to the rule protocol position determination block 20E via the signal line SL7.
  • the correction block 20D acquires information about the subject E (training target person) input via the input device 5 via the signal line SL8.
  • the information regarding the subject E is, for example, the identification number, gender, age, height, etc. of the subject E, and may include other physique information and the like.
  • the correction block 20D is based on the acquired information about the subject E (for example, data such as the height, body shape, and gender of the subject E), and the correct position (for example, the position of the hand), the posture, and the posture according to the protocol when performing each target work. It has a function to create data for correcting data related to operations (model data).
  • the data for correcting the position, posture, motion, etc. along the protocol corrected by the correction block 20D is transmitted to the rule protocol position determination block 20E via the signal line SL9.
  • the protocol position determination block 20E acquires information on the type of the target program from the program determination block 20C via the signal line SL7, and the correct position along the protocol (for example, the position of the hand) from the database 20K via the signal line SL10. ), Posture, motion data, etc., and data (correction data) for correcting the position, posture, motion data according to the protocol from the correction block 20D via the signal line SL9 according to the height of subject E, etc. get.
  • the rule protocol position determination block 20E has a function of determining a correct position, posture, motion, etc. (corrected position, posture, motion, etc.) according to the protocol based on the correction data for the subject E.
  • Data such as accurate (corrected) position, posture, and motion according to the protocol determined by the rule protocol position determination block 20E are transmitted to the rule protocol image creation block 20F via the signal line SL11, and are also transmitted. It is transmitted to the comparison block 20G via the signal line SL12.
  • the rule protocol image creation block 20F has a function of calculating and creating an image or video of an accurate position, posture, motion, etc. according to the protocol based on the data acquired from the rule protocol position determination block 20E. ..
  • the image (video) created by the protocol image creation block 20F is transmitted to the comparison block 20G via the signal line SL13.
  • the comparison block 20G includes the position, posture, motion, etc. in the image of the subject E acquired from the avatar creation block 20B, and accurate data (position, posture, motion, etc.) according to the protocol acquired from the rule protocol position determination block 20E. Has a function to compare. At the time of comparison in the comparison block 20G, the difference between the data such as the position, posture, and movement in the image of the subject E and the data such as the accurate position, posture, and movement according to the protocol is calculated. The difference is compared with a predetermined value (threshold value) set in advance in the procedure pass / fail judgment block 20H, and it is determined whether or not the work targeted for the education has been performed accurately.
  • a predetermined value threshold value
  • the image (video) of the subject E acquired from the avatar creation block 20B is compared with an accurate image (video) according to the protocol acquired from the rule protocol image creation block 20F (that is,).
  • the protocol acquired from the rule protocol image creation block 20F (that is,).
  • the data such as position, posture, and motion may be compared with the data such as accurate position, posture, and motion according to the protocol instead of the position and the like of the image (video).
  • comparison block 20G (A) Comparison of data such as the position of the image (avatar) of subject E and the exact position according to the protocol, (B) Comparison of the image (avatar) of subject E with the image (avatar) of the exact position, posture, movement, etc. according to the protocol. (C) Comparison of data such as the position of subject E and data such as the exact position according to the protocol, Is done.
  • the comparison result by the comparison block 20G is transmitted to the procedure pass / fail judgment block 20H via the signal line SL14.
  • the procedure pass / fail determination block 20H has a function of determining the pass / fail of the position, posture, movement, etc. (that is, work procedure) of the subject E in the work to be educated, based on the comparison result obtained from the comparison block 20G.
  • the work procedure of subject E is "good", that is, acceptable when the difference in (A) to (C) is equal to or less than a preset first predetermined value in the judgment. Judge as (pass).
  • the work procedure of the subject E is determined to be "poor", that is, unacceptable (failed).
  • the difference is larger than the first predetermined value but less than or equal to the second predetermined value (greater than the first predetermined value) (the difference is a small difference)
  • the work procedure of the subject E is described as "bad There is, but the degree of defect is small.
  • the difference is larger than the second predetermined value (the difference is large)
  • the determination result of the procedure pass / fail determination block 20H is transmitted to the display moving image determination block 20I via the signal line SL15.
  • the display moving image determination block 20I has a function of determining an image (moving image) to be displayed (viewed: confirmed) on the VR based on the determination result acquired from the procedure pass / fail determination block 20H.
  • the difference between the image of subject E (position, posture, movement, etc.) and the accurate position, posture, movement, etc. according to the protocol is less than or equal to the first predetermined value, that is, the procedure is good or bad.
  • the pass / fail judgment result from the judgment block 20H is "good"
  • a video (video) indicating that the work procedure is "good” and acceptable (pass) is displayed on the VR.
  • the pass / fail judgment result from the procedure pass / fail judgment block 20H is "no", and the difference between the image of subject E (position, posture, movement, etc.) and the accurate position, posture, movement, etc. according to the protocol is the first.
  • the subject E is, for example, in the work procedure (position, posture, movement, etc.) and protocol of the subject E.
  • An image (moving image) that clearly shows the difference from the exact position, posture, movement, etc. along the line is displayed on the VR.
  • the video that clearly shows the difference may be calculated and created as a video that the subject E can understand by himself / herself about the difference between the work procedure performed by the subject E on the VR and the accurate work procedure according to the protocol. desirable.
  • the work procedure of subject E and the accurate work procedure according to the protocol are superimposed and displayed, and a video (moving image) in which the difference between the two becomes clear is displayed on the VR.
  • a video (moving image) of an accurate position, posture, motion, etc. according to the protocol may be simply displayed on the VR.
  • the pass / fail judgment result from the procedure pass / fail judgment block 20H is "no", and the difference between the image of subject E (position, posture, movement, etc. in) and the accurate position, posture, movement, etc.
  • the second predetermined value is the second predetermined value. If it is larger than the value, that is, if the degree of defect is large, the video (animation) displayed to the subject E on the VR should be such that the subject E takes the evaluation result seriously, for example, a work procedure. An animation or the like showing how the cultured stem cells are completely destroyed due to the above is displayed on the VR.
  • the determination result of the display moving image determination block 20I is transmitted to the moving image creation block 20J via the signal line SL16.
  • the video creation block 20J acquires the corresponding video (video) data from the database 20K via the signal line SL17 based on the determination result acquired from the display video determination block 20I, and based on the evaluation result of the education (training). It has a function to create a video (moving image).
  • each type of education (training) related to cell culture is evaluated by education (“judgment result is good”, “judgment result is poor and its degree is small”, and “judgment result is poor”.
  • the video (video) data corresponding to "the degree is large" is saved.
  • the video (video) of the database 20K It is also possible to create a video (video) by processing the avatar (image) data in addition to the data.
  • the video (moving image) data created by the moving image creation block 20J is transmitted to the display device 4 (monitor) via the signal line SL18 and is broadcast on the display device 4. Further, the data of the video (moving image) is transmitted to the goggles 2 worn by the subject E via the signal line SL1-2, and is broadcast on the VR.
  • the database 20K contains the target program corresponding to each education (training) related to cell culture, the accurate position (for example, hand position), posture, movement, etc. of the worker according to the protocol in each education target work. Data, videos (videos) for each evaluation based on the evaluation results of the education (training), etc. are saved, and the contents saved by each functional block are transmitted as needed.
  • a plurality of training contents customized for each company or institution described above, and data in virtual reality such as the plurality of various facilities and instruments are stored.
  • the practitioner when carrying out the training, the practitioner (subject E, etc.) operates the input device 5 to select 1 from the three modes of "scenario mode", “simulation mode”, and "trial mode". Select one.
  • the mode switching block 5A (see FIG. 1: not shown in FIG. 2) transmits a mode selection signal to the control device 20 via the signal line SL19.
  • the control device 20 that has received the mode selection signal executes control according to the mode. For example, in the scenario mode, since the subject E does not perform the work operation, the subject position determination block 20A, the avatar creation block 20B, and the like in FIG. 2 do not function. Therefore, the movement of the subject E and the position, posture, movement, etc.
  • the program determination block 20C, the rule protocol position determination block 20E, the comparison block 20G, the procedure pass / fail judgment block 20H, etc. Does not work either.
  • the VR video that serves as a model (model) in the scenario mode and the function of reproducing and teaching the work procedure as text information and voice information are provided by the database 20K, the video creation block 20J, the display device 4, and the goggles 2. Will be executed. Further, when the trial mode is performed, each block in the control device 20 is functioning and executed. Further, in the simulation mode, if the movement of the subject E is not compared and evaluated with the position, posture, movement, etc. along the protocol, the blocks related to the comparison and evaluation do not function.
  • step S1 it is determined whether or not the training program (training or education related to cell culture) to be performed has been selected. Specifically, it is determined whether or not the training type is input to the program determination block 20C of the control unit 20 (control device, see FIG. 2) via the input device 5.
  • step S1 if the training program is selected (step S1 is "Yes"), the process proceeds to step S2, and if the training type is not selected (step S1 is "No"), the process returns to step S1 (step S1 is "Yes”). No "loop).
  • step S2 information on the position (for example, the position of the hand), posture, movement, etc. of the subject E is input from the gloves 1 (1A, 1B), the goggles 2, and the camera 3 worn by the subject E.
  • information on the position, posture, movement, etc. of the subject E is input from the glove 1 (1A, 1B), the goggles 2, the camera 3 to the subject position determination block 20A of the control unit 20.
  • the position and posture of the subject E are specified from the information on the position, posture, movement and the like acquired in step S2.
  • the movement of the subject E in VR including AR
  • the position, posture, motion, etc. of the subject E are specified by the subject position determination block 20A of the control unit 20.
  • the avatar creation block 20B calculates and creates an avatar (image: for example, a hand image) of the subject E and displays it on the VR.
  • step S4 the position, posture, movement, etc. of the subject E are compared with the accurate position, posture, movement, etc. on the protocol (comparison block 20G, etc.).
  • step S4 of FIG. 3 will be described separately.
  • step S41 the type of training (education) related to the cell culture to be performed is read, and the data (gender, age, height, etc.) related to the subject E is read.
  • the type of training is input from the input device 5 (FIG. 2) to the program determination block 20C, and the data regarding the subject E is input from the input device 5 to the correction block 20D.
  • step S42 the process proceeds to step S42.
  • step S42 the correct position, posture, motion, etc. (model motion, etc.) on the protocol in the selected (specified) training (education) are read.
  • the reading is performed by the rule protocol position determination block 20E, the training type is acquired from the program determination block 20C, and the data corresponding to the training type is acquired from the database 20K and executed.
  • the data such as the correct position, posture, and movement on the protocol read from the database 20K is corrected to the accurate data corresponding to the subject E according to the data (gender, age, height, etc.) related to the subject E. To do.
  • the correction is performed in the rule protocol position determination block 20E, and is executed after acquiring the correction amount data based on the data of the subject E from the correction block 20D. Then, the process proceeds to step S43.
  • step S43 the position, posture, movement, etc. of the subject E are compared with the accurate position, posture, movement, etc. on the protocol corrected by the data of the subject E.
  • the comparison in step S43 is performed in comparison block 20G.
  • the position, posture, motion, etc. of the subject E are determined based on the image (avatar) of the subject E acquired from the avatar creation block 20B, and the accurate position, posture, motion, etc. on the corrected protocol are determined. It is determined from the data acquired from the rule protocol position determination block 20E or the video relating to the accurate position, posture, motion, etc. along the protocol acquired from the rule protocol image creation block 20F.
  • the position, posture, movement, etc. the position, posture, movement, etc.
  • step S5 the process proceeds to step S5 (FIG. 3).
  • step S5 based on the comparison result of step S4, the difference between the image of subject E (position, posture, movement, etc.) and the accurate position, posture, movement, etc. on the protocol is within the permissible range. Determine if it exists. In other words, it is determined whether or not the position, posture, movement, etc. of the subject E are good (whether or not it is "passed”). Judgment as to whether or not the position, posture, movement, etc. of subject E is good (whether or not it is "passed") is described above in the comparison block 20G and the procedure pass / fail judgment block 20H with reference to FIG. Performed in an embodiment.
  • step S5 If the difference is within the permissible range in step S5 (step S5 is “Yes”: the difference is within the first predetermined value), the process proceeds to step S6, and if the difference is not within the permissible range (step S5 is “No”). : The difference is larger than the first predetermined value), the process proceeds to step S7.
  • step S6 step S5 is "Yes”: the difference is within the first predetermined value
  • step S6 when the training is terminated (step S6 is “Yes”), the procedures shown in FIGS. 3 and 4 are terminated, and when the training is not completed (step S6 is “No”), step S2 is performed.
  • step S6 returns to step S2 without completing the training (step S6 is “No”), the subject E continues to carry out the same type of training as before.
  • subject E desires other training, he / she can return to step S1 instead of returning to step S2. In that case (when returning to step S1), the subject E can select the training again and perform the desired training.
  • step S7 (“No” in step S5: the difference is larger than the first predetermined value), the subject E receives a judgment result that the position, posture, movement, etc. of the subject E are not within the permissible range and is not good.
  • a video (video) for confirming (recognizing) the evaluation result of the education (training) is determined and displayed on the VR.
  • step S7 in FIG. 3 will be described by dividing it into a plurality of detailed steps as shown in FIG.
  • Step S7 of FIG. 3 is a case where it is determined in step S5 that the difference between the position, posture, movement, etc. of the subject E and the accurate position, posture, movement, etc. on the protocol is not within the permissible range.
  • step S71 if the difference is larger than the second predetermined value (the difference is a large difference), the process proceeds to step S72, and if the difference is equal to or less than the second predetermined value (the difference is a small difference). In the case of), the process proceeds to step S73.
  • step S72 when the difference is larger than the second predetermined value, a predetermined image (moving image) is broadcast on VR (AR) to the subject E having a large difference.
  • the video (video) is intended to take the evaluation results more seriously. For example, an animation in which the cultured stem cells are completely destroyed due to the work procedure is displayed on VR. Display with.
  • step S73 when the difference is equal to or less than the second predetermined value, an image (moving image) for the subject E having a small difference is broadcast on VR (AR).
  • the work procedure (position, posture, movement, etc.) of subject E and the accurate position, posture, movement, etc. according to the protocol are superimposed and displayed to clarify the difference between the two.
  • step S8 it is determined whether or not to continue the training (education) related to cell culture.
  • step S8 if the training is continued (step S8 is “Yes”), the process returns to step S2, and if the training is not continued (step S8 is “No”), the procedure of FIG. 3 ends. Similar to the case where step S6 is "No”, when returning to step S2 without finishing the training (step S8 is "No"), the subject E continues to carry out the same type of training as before. If subject E wishes to have another training, he / she can return to step S1 instead of returning to step S2. In that case (when returning to step S1), the subject E can select the training again and perform the desired training.
  • step S11 training is performed for individual tasks related to cell culture (cell isolation, cell culture, gouning, etc.).
  • step S11 the contents of various trainings described with reference to FIGS. 3 to 5 are executed. Details of step S11 will be described later with reference to FIG.
  • step S12 as a result of the training in step S11, the instructor (training instructor) who instructed the training performed by the subject E determines whether or not the subject E has passed.
  • the instructor basically allows a difference between the position, posture, movement, etc. of the subject E and the exact position, posture, movement, etc. on the protocol.
  • step S12 if the instructor decides to pass (step S12 is “Yes”), the process proceeds to step S13, and if the instructor does not pass (step S12 is “No”), the process returns to step S11. Repeat the training.
  • step S13 when the instructor is found to pass in step S12, it is determined whether or not the instructor has passed all the work training related to cell culture of subject E. As a result of the determination in step S13, if the instructor recognizes that all the work has passed (step S13 is "Yes"), the process proceeds to step S15, and if the instructor does not recognize that all the work has passed (step S13 is "Yes”). "No") proceeds to step S14.
  • step S14 when the instructor has not certified that all the work has passed, the subject E trains (educates) the work that the instructor has not certified as passing.
  • the process returns to step S12.
  • the instructor evaluates that the result of the training in step S14 (position, posture, movement, etc. of the subject E) has passed. Determine if you did.
  • step S15 when the instructor finds that all the tasks have passed, subject E is subjected to a comprehensive test for all tasks related to cell culture.
  • the comprehensive test may be performed by subject E performing all the work trainings in succession, or a test for comprehensively testing the work training of subject E performed in steps S11 to S13 is executed. You may.
  • step S16 it is determined whether or not the subject E has passed the comprehensive test of step S15. If subject E passes the comprehensive test as a result of the determination in step S16 (step S16 is “Yes”), the procedure of FIG. 6 is terminated. On the other hand, if the subject E does not pass the comprehensive test (step S16 is “No”), the process proceeds to step S17.
  • step S17 subject E retrains the work that failed the comprehensive test in step S16.
  • the process returns to step S12.
  • the instructor verifies that the result of the retraining of step S17 (position, posture, movement, etc. of the subject E) has passed. Judge whether or not. It is also possible to omit the step (step S13) of determining whether or not the instructor has confirmed that all the work training related to the cell culture of the subject E has passed.
  • step S11 of FIG. 6 will be described with reference to FIG. 7.
  • a selection is made from "scenario mode", "simulation mode”, and "trial mode”, and training (education) in the selected mode is executed. , Then perform other modes of training (education) as needed.
  • the scenario mode is mainly aimed at beginners
  • the simulation mode is mainly aimed at beginners who can understand the work procedure to some extent.
  • the trial mode is carried out so that a person who has experienced the scenario mode and the simulation mode can confirm the proficiency level.
  • step S21 it is determined whether or not the training (education) mode has been selected in the training (training or education related to cell culture) to be performed. Specifically, it is determined whether or not the mode selection signal is transmitted to the control device 20 via the input device 5. In step S21, if the mode is selected (step S21 is “Yes”), the process proceeds to step S22, and if the mode is not selected, the process returns to step S21 (step S21 is a “No” loop).
  • step S22 in order to execute training (education) in the mode selected in step S21, the process proceeds to any one of steps S23, S24, and S25. That is, if the scenario mode is selected in step S22, the process proceeds to step S23, if the simulation mode is selected, the process proceeds to step S24, and if the trial mode is selected, the process proceeds to step S26.
  • step S23 training (education) in the scenario mode is carried out.
  • the scenario mode for the work related to the cell culture to be trained, a video of the position (for example, the position of the hand), the posture, and the movement of the model worker (for example, the position of the hand) in virtual reality (VR) Show to subject E.
  • the content of specific instructions for correct posture, movement, etc. is displayed as character information (caption).
  • Character information can also be reproduced as voice information.
  • the model moving image, character information, and voice information are displayed by the control device 20 on the display device 4 and / or the goggles 2 worn by the subject E.
  • the model moving image is produced in a state of being viewed from a plurality of viewpoints (in a multi-angle), and the produced moving image can switch the viewpoints.
  • the subject E has no choice but to look into from behind the performer, and the learner's viewpoint is limited to the back of the performer. In that respect, it differs from VR video from multiple angles that can be observed from various useful angles.
  • step S23 character information (caption) for instructing points to be noted and necessary points in the work is also displayed in addition to the sample moving image as described above. Character information can also be reproduced as voice information. Further, in the scenario mode of step S23, a model worker's position (for example, hand position), posture, and attention points for movement are displayed. The display of the caution point is performed by the control device 20 on the display device 4 and / or the goggles 2 worn by the subject E, and the display of the caution point is executed at a timing effective for education. When step S23 is completed, the process proceeds to step S28.
  • step S24 it is determined whether or not the subject E who has selected the simulation mode has already performed training (education) in the scenario mode. If the training (education) in the scenario mode has already been performed (step S24 is “Yes”), the process proceeds to step S25, and if the training (education) in the scenario mode has not been performed (step S24 is “No”), step S21 Return to. That is, in the illustrated embodiment, it is set so that the subject E cannot receive the training (education) in the simulation mode if the subject E has not received the training (education) in the scenario mode. This is because more efficient training (education) can be expected by experiencing the scenario mode and then implementing the simulation mode. However, it is possible to set the simulation mode so that the subject E can execute the simulation mode even when the scenario mode is not executed.
  • step S25 training (education) in the simulation mode is carried out.
  • Subject E wears the measuring device 10 (left-handed glove 1A, right-handed glove 1B, goggles 2) and performs the operation of the cell culture work to be trained in virtual reality for practice.
  • the above-mentioned training (education) is executed with reference to FIGS. 3 to 5.
  • the position, posture, and movement of subject E are compared with the data (position, posture, movement) according to the protocol (in virtual reality or between the data), and the difference is within the permissible range. Confirm whether or not it is, and evaluate it. However, comparison and evaluation can be omitted.
  • the subject E can receive instructions (work instruction scenario guide) regarding the work by voice or letters.
  • the work instruction scenario guide can be transmitted to the subject E from a voice device (not shown). And / or, the work instruction scenario guide is displayed on the display device 4 and / or the goggles 2 worn by the subject E.
  • the elapsed time of the work of the subject E regarding the stem cell culture to be trained is measured.
  • the measurement of the elapsed time includes both the measurement of the elapsed time in each operation constituting the work and the measurement of the elapsed time until the entire work is completed (the elapsed time of the entire work).
  • the working time is measured in the training in the virtual reality, and it is confirmed whether or not the working time is appropriate so that the actual work does not adversely affect the cells.
  • the control device 20 has a timer function.
  • the training in the simulation mode when subject E makes an operation error or failure (for example, the position, posture, and movement are significantly different from the position, posture, and movement based on the protocol) during the work movement, voice or character display is performed.
  • An alert is issued by (for example, reddening of characters).
  • the alert is uttered by the control device 20 from a voice device (not shown) and / or displayed on the display device 4 and the goggles 2 worn by the subject E.
  • the important attention points are confirmed so that the position, posture, and movement of the subject E become (approach) the position, posture, and movement based on the protocol (for example, the movement that is the point is appropriate). Check if it was possible to execute).
  • the confirmation result is displayed by the control device 20 on the display device 4 and / or the goggles 2 worn by the subject E. There are no particular restrictions on the timing of displaying the confirmation result, but it is desirable that the confirmation result be displayed at a timing that improves the training efficiency of subject E.
  • step S25 the process proceeds to step S28.
  • step SS26 When the training (education) in the trial mode is executed, it is determined in step SS26 whether or not the training (education) in the scenario mode and the simulation mode has already been executed. If the training (education) in the scenario mode and the simulation mode has already been carried out in step S26 (step S26 is “Yes”), the process proceeds to step S27, and the training (education) in the scenario mode and the simulation mode has not been carried out (step S26). Step S26 is "No") returns to step S21. That is, in the illustrated embodiment, the trial mode is not executed for the subject who has not experienced the scenario mode and the simulation mode. As described above, the trial mode is an embodiment performed to confirm the proficiency level, and it is meaningless to execute it by a subject who has not performed the scenario mode or the simulation mode.
  • step S27 subject E wears the measuring device 10 (left-handed glove 1A, right-handed glove 1B, goggles 2) and performs a cell culture work (operation) to be trained in virtual reality to confirm work proficiency.
  • a series of work procedures are carried out without interruption until the end.
  • the position, posture, and movement of the subject E are compared with the data (position, posture, movement) according to the protocol (in virtual reality or between the data). Check and evaluate whether the difference is within the permissible range.
  • the elapsed time of the work of subject E regarding the stem cell culture to be trained is measured, and whether the measurement result (elapsed time for each movement constituting the work and the elapsed time for the entire work) is appropriate. Check if it is not.
  • step S27 when the subject E makes an operation error or failure (for example, the position, posture, or motion is significantly different from the position, posture, or motion based on the protocol) during the work operation, the error or the failure is made.
  • the details of the failure are recorded by the control device 20. Even if such a mistake or failure is made, the trial mode is continued without interruption, and the subject confirms the record of the mistake or failure after the trial mode ends. This is to bring the trial mode closer to the actual work that cannot be interrupted because no alarm sound is emitted or an alarm is displayed even if an operation error or failure is made.
  • step S27 The evaluation in the training (education) in the trial mode compares the position, posture, and movement of subject E with the data (exemplary position, posture, movement) according to the protocol (in virtual reality or between data). A pass / fail judgment is made based on whether or not the difference is within the permissible range. At that time, score evaluation may be adopted.
  • step S27 the process proceeds to step S28.
  • step S28 subject E determines whether or not he / she has passed the training (education) in the trial mode.
  • step S28 if the subject E passes the trial mode (step S28 is “Yes”), the process proceeds to step S12. On the other hand, if the subject E has not passed the trial mode (step S28 is “No”), the process returns to step S21, and the trial mode is performed again, the training is performed in the simulation mode, or the model work is performed in the scenario mode. Select whether to reconfirm the procedure.
  • step S12 a person who has passed the trial mode proceeds to step S12 (FIG. 6) and receives a pass / fail judgment by the instructor.
  • step S28 if the subject E passes the trial mode (step S28 is “Yes”), the process proceeds to step S13, and step S12 can be omitted.
  • the trial mode in step S27 can be changed to a pass / fail judgment by the instructor in step S12.
  • techniques related to stem cell culture are trained using virtual reality (VR) without using an actual living body (human body) or facility. Therefore, the ability to perform necessary processing can be efficiently improved. Since it is not necessary to use an actual living body (human body) or facility, there is no limitation on the place where training or education is performed, and it is possible to remove the limitation on the time for training or education.
  • VR virtual reality
  • the illustrated embodiment is merely an example and is not a description intended to limit the technical scope of the present invention.
  • it is possible to appropriately combine the determination of the state of the cells actually cultured.
  • it can be combined with not only the check in the virtual reality but also the check of the practical skill (check of the actual work).

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Abstract

Le but de la présente invention est de fournir un système ou un procédé d'apprentissage et de maîtrise d'une technique liée à la culture de cellules souches, à l'aide d'une technologie de réalité virtuelle (VR). À cet effet, ce système de formation de culture cellulaire (100) comprend un dispositif de mesure (10 : gants 1, lunettes 2, caméra 3, etc.) et un dispositif de commande (20) qui mesure la position, la posture et le mouvement corporel d'un sujet (E). Le dispositif de commande (20) comprend : une fonction de calcul de la position, de la posture et du mouvement corporel du sujet (E) à l'aide d'informations issues du dispositif de mesure (10), d'exécution de la préparation et de l'affichage des résultats de celle-ci en réalité virtuelle ; une fonction de modification du calcul, conformément au sujet (E) (sa hauteur, etc.), à partir de données (de la position, de la posture, du mouvement corporel, etc.) basées sur un protocole de technique de culture cellulaire, de calcul de la position, de la posture et du mouvement corporel qui seraient réalisés si le sujet (E) suivait le protocole, et de préparation des données (position, posture, mouvement corporel, etc.) ; et une fonction de comparaison de la position, de la posture et du mouvement corporel du sujet (E) avec les données qui correspondent au protocole.
PCT/JP2020/013940 2019-03-27 2020-03-27 Système et procédé de formation de culture cellulaire WO2020196818A1 (fr)

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JP7411856B2 (ja) 2020-12-31 2024-01-11 オベロン・テクノロジーズ・インコーポレイテッド 仮想現実環境ベースの訓練及び認証を提供するためのシステム及び方法
TWI845462B (zh) 2024-01-03 2024-06-11 亞東學校財團法人亞東科技大學 虛擬實境培訓系統及其培訓方法

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JP2018185501A (ja) * 2017-08-25 2018-11-22 株式会社ｍｅｄｉＶＲ リハビリテーション支援システム、リハビリテーション支援方法およびリハビリテーション支援プログラム

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7411856B2 (ja) 2020-12-31 2024-01-11 オベロン・テクノロジーズ・インコーポレイテッド 仮想現実環境ベースの訓練及び認証を提供するためのシステム及び方法
TWI845462B (zh) 2024-01-03 2024-06-11 亞東學校財團法人亞東科技大學 虛擬實境培訓系統及其培訓方法

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