WO2020195480A1 - 溶存水素水生成装置及び溶存水素水生成方法 - Google Patents

溶存水素水生成装置及び溶存水素水生成方法 Download PDF

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Publication number
WO2020195480A1
WO2020195480A1 PCT/JP2020/007729 JP2020007729W WO2020195480A1 WO 2020195480 A1 WO2020195480 A1 WO 2020195480A1 JP 2020007729 W JP2020007729 W JP 2020007729W WO 2020195480 A1 WO2020195480 A1 WO 2020195480A1
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Prior art keywords
hydrogen water
dissolved
dissolved hydrogen
hydrogen
water
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PCT/JP2020/007729
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English (en)
French (fr)
Japanese (ja)
Inventor
直樹 仲西
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株式会社日本トリム
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Priority to CN202080013254.0A priority Critical patent/CN113412128B/zh
Publication of WO2020195480A1 publication Critical patent/WO2020195480A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes

Definitions

  • the present invention relates to a dissolved hydrogen water generator for producing dissolved hydrogen water used for preparing a dialysate and a method for producing dissolved hydrogen water.
  • the present invention has been devised in view of the above circumstances, and provides a technique for controlling the production of dissolved hydrogen according to the hydrogen delivered to the patient's body in hemodiafiltration treatment using dissolved hydrogen water.
  • the main purpose is to do.
  • the first invention of the present invention is a dissolved hydrogen water generator for generating dissolved hydrogen water in which hydrogen is dissolved in water, and is prepared by a hydrogen water generating unit for generating the dissolved hydrogen water and the dissolved hydrogen water. Based on the detection unit for detecting hydrogen gas contained in the exhaled breath of a patient undergoing dialysis using the dialysate and the detection result of the detection unit, the dissolved hydrogen concentration of the dissolved hydrogen water is increased or A control unit for controlling the hydrogen water generation unit is provided so as to make it smaller.
  • control unit controls the hydrogen water generation unit based on the presence or absence of the hydrogen gas.
  • control unit controls the hydrogen water generation unit based on the amount of the hydrogen gas per unit volume of the exhaled breath.
  • control unit controls the hydrogen water generation unit based on the average value of the amounts.
  • control unit controls the hydrogen water generation unit based on the cumulative value of the amount.
  • the dissolved hydrogen water generator according to the present invention further includes a notification unit for notifying the amount of the hydrogen gas.
  • the hydrogen water generating unit includes an anode feeding body and a cathode feeding body for electrolyzing the water
  • the control unit is a dissolved hydrogen of the dissolved hydrogen water. It is desirable to control the current for electrolysis supplied to the anode feeder and the cathode feeder so as to increase or decrease the concentration.
  • the hydrogen water generating unit includes an anode feeding body and a cathode feeding body for electrolyzing the water, and the control unit has a predetermined amount. When it is smaller than the threshold value, it is desirable that the control unit increases the current for electrolysis supplied to the anode feeder and the cathode feeder.
  • the second invention of the present invention is a method for producing dissolved hydrogen water in which hydrogen is dissolved in water, wherein the dissolved hydrogen water is generated by electrolyzing the water. Based on the detection step of detecting hydrogen gas contained in the exhaled breath of a patient undergoing dialysis using the dialysate prepared with the dissolved hydrogen water and the detection result of the hydrogen gas, the dissolved hydrogen of the dissolved hydrogen water It includes a control step of controlling the concentration.
  • the dissolved hydrogen water generator of the first invention generates the hydrogen water based on the detection unit that detects the hydrogen gas contained in the exhaled breath of the patient during dialysis and the detection result of the detection unit. It is provided with the control unit for controlling the unit. This makes it possible to appropriately control the production of the dissolved hydrogen water used in the preparation of the dialysate based on the hydrogen delivered to the patient's body.
  • the dissolved hydrogen water is based on the detection step of detecting the hydrogen gas contained in the exhaled breath of the patient during dialysis and the detection result of the hydrogen gas. It includes a control step of controlling the dissolved hydrogen concentration. This makes it possible to appropriately control the dissolved hydrogen concentration of the dissolved hydrogen water used for preparing the dialysate based on the hydrogen delivered to the patient's body.
  • FIG. 1 It is a figure which shows the schematic structure of the dialysis system including the dissolved hydrogen water generation apparatus of this invention. It is a figure which shows the electrolytic cell which is an example of the dissolved hydrogen water generation part of FIG. It is a flowchart which shows the processing procedure of the dissolved hydrogen water generation method used for the dissolved hydrogen water generation apparatus of FIG. It is a flowchart which shows the processing procedure of the modification of the dissolved hydrogen water generation method of FIG. It is a flowchart which shows the processing procedure of another modification of the dissolved hydrogen water generation method of FIG. It is a flowchart which shows the processing procedure of still another modification of the dissolved hydrogen water generation method of FIG.
  • FIG. 1 shows a schematic configuration of a dialysis system 100 including the dissolved hydrogen water generator 1 of the present embodiment.
  • the dissolved hydrogen water generator 1 is an apparatus for generating dissolved hydrogen water in the dialysis system 100 in which the dialysate prepared by the dissolved hydrogen water generation is used.
  • the dialysis system 100 includes a reverse osmosis membrane treatment device 2, a dissolved hydrogen water generation device 1, a dialysate preparation device 5, and a dialysis device 6.
  • the reverse osmosis membrane treatment device 2 purifies the raw water by the reverse osmosis treatment and supplies it to the dissolved hydrogen water generation device 1.
  • Tap water is generally used as the raw water, but other water such as well water and groundwater can also be used.
  • the reverse osmosis membrane treatment device 2 includes a water softening treatment device 21, an activated carbon treatment device 22, and a reverse osmosis membrane module 23.
  • the water softening treatment device 21 removes hardness components such as calcium ions and magnesium ions from the raw water to soften the water.
  • the activated carbon treatment device 22 has activated carbon which is a fine porous substance, and adsorbs and removes chlorine and the like from the water supplied from the water softening treatment device 21.
  • the reverse osmosis membrane module 23 separates the water supplied from the activated carbon treatment apparatus 22 into treated water purified by the reverse osmosis membrane and concentrated water containing impurities.
  • the treated water purified by the reverse osmosis membrane module 23 is sent to the dissolved hydrogen water generator 1.
  • the concentrated water that could not permeate the reverse osmosis membrane is discharged to the outside of the reverse osmosis membrane treatment device 2.
  • the dissolved hydrogen water generation device 1 adds hydrogen to the water purified by the reverse osmosis membrane treatment device 2 to generate dissolved hydrogen water.
  • the dissolved hydrogen water generation device 1 includes a hydrogen water generation unit 3 for generating dissolved hydrogen water (hydrogen-containing water) in which hydrogen gas is dissolved.
  • the electrolytic cell 4 is applied as a part of the hydrogen water generation unit 3. The details of the electrolytic cell 4 will be described later.
  • the dissolved hydrogen water generated by the hydrogen water generation unit 3 is sent to the dialysate preparation device 5 as dialysate preparation water.
  • the dialysate preparation device 5 prepares a dialysate by diluting, for example, a liquid dialysate using the dialysate preparation water supplied from the hydrogen water generation unit 3.
  • the dialysate prepared by the dialysate preparation device 5 is sent to the dialysate device 6.
  • the dialysing device 6 includes a dialysate supply device 61 and a dialyzer 62.
  • the dialysate supply device 61 sends the dialysate supplied from the dialysate preparation device 5 to the dialyzer 62.
  • the dialyzer 62 is an artificial kidney including a dialysis membrane 62a composed of, for example, a porous membrane such as a hollow yarn membrane, and receives dialysate treatment on the dialysate supplied from the dialysate preparation device 5 via the dialysis membrane 62a. It acts on the blood of patient H to remove waste products and water from the blood.
  • Patient H and dialyzer 62 are connected via blood circuits 63 and 64.
  • the blood circuit 63 sends the blood collected from the patient H to the dialyzer 62.
  • the blood circuit 63 is provided with a pump 65 for delivering blood.
  • the blood circuit 64 returns the blood from which waste products and the like have been removed by the dialyzer 62 to the patient H.
  • the dissolved hydrogen water generation device 1 includes a collection unit 11 for collecting the exhaled breath of the patient H, a detection unit 12 for detecting the hydrogen gas contained in the exhaled breath of the patient H, and the like.
  • a control unit 13 for controlling the hydrogen water generation unit 3 is provided.
  • the collection unit 11 is attached to the nose and mouth of the patient H, collects the exhaled breath of the patient H, and sends it to the detection unit 12.
  • the detection unit 12 detects the hydrogen gas contained in the exhaled breath of the patient H and outputs the corresponding electric signal to the control unit 13.
  • a known hydrogen gas detector or the like can be applied to the detection unit 12. In the form in which the detection unit 12 capable of detecting hydrogen gas from the exhaled breath of the patient H or the like is used, the collection unit 11 is unnecessary.
  • the control unit 13 is composed of, for example, a CPU (Central Processing Unit) that executes various arithmetic processes, information processing, etc., a program that controls the operation of the CPU, a memory that stores various information, and the like.
  • the control unit 13 controls each unit of the dissolved hydrogen water generator 1.
  • control unit 13 controls the hydrogen water generation unit 3 based on the electric signal input from the detection unit 12, that is, the detection result of the detection unit 12. For example, when hydrogen gas is detected in the exhaled breath of patient H, it is confirmed that the hydrogen added in the hydrogen water generation unit 3 surely reaches and is absorbed in the body of patient H via dialysate and blood. Therefore, the operation of the hydrogen water generation unit 3 is weakened or stopped.
  • the control unit 13 may control the operation of the hydrogen water generation unit 3 so as to increase the dissolved hydrogen concentration.
  • the dissolved hydrogen water generator 1 it is possible to appropriately control the generation of dissolved hydrogen water used for preparing the dialysate based on the hydrogen delivered to the body of the patient H.
  • the detection unit 12 detects the amount of hydrogen gas per unit volume of exhaled breath
  • the control unit 13 detects hydrogen water based on the amount of hydrogen gas detected by the detection unit 12. It is desirable that it is configured to control the generation unit 3.
  • the control unit 13 appropriately controls the hydrogen water generation unit 3 by calculating the amount of hydrogen gas per unit volume of exhaled breath and comparing it with a predetermined first threshold value.
  • the first threshold value can be determined, for example, by statistically processing information on the transition of the symptoms of patient H (hereinafter, the same applies to the second threshold value to the sixth threshold value).
  • the hydrogen water generation unit 3 can be appropriately controlled based on the concentration of hydrogen gas in the exhaled breath.
  • the amount of hydrogen gas may be volume, molecular weight, etc. in addition to mass. Further, the control unit 13 may be configured to calculate the amount of hydrogen gas contained in the exhaled breath exhaled from the patient H in a unit time.
  • the control unit 13 may be configured to control the hydrogen water generation unit 3 based on the average value of the amount of hydrogen gas per unit volume of exhaled breath. ..
  • the control unit 13 controls the hydrogen water generation unit 3 by calculating the average value of the amount of hydrogen gas per unit volume of exhaled breath and comparing it with a predetermined second threshold value. It is desirable that the control unit 13 calculates the moving average value at regular time intervals as the average value. With such a configuration, it is possible to appropriately control the hydrogen water generation unit 3 without being affected by minute fluctuations in the concentration of hydrogen gas in the exhaled breath.
  • the control unit 13 controls the hydrogen water generation unit 3 by calculating the cumulative value of the amount of hydrogen gas detected by the detection unit 12 and comparing it with a predetermined third threshold value.
  • the hydrogen water generation unit 3 can be appropriately controlled based on the hydrogen gas accumulated in the body of the patient H.
  • the dissolved hydrogen water generator 1 further includes a notification unit 14 for notifying the amount of hydrogen gas.
  • a notification unit 14 for notifying the amount of hydrogen gas.
  • an LED that outputs an optical signal, a speaker device that outputs an audio signal, or the like is applied to the notification unit 14.
  • the notification may be a combination of an optical signal and an audio signal.
  • the operation of the notification unit 14 is controlled by, for example, the control unit 13.
  • FIG. 2 shows the electrolytic cell 4 constituting the hydrogen water generation unit 3.
  • the electrolytic cell 4 generates hydrogen molecules by electrolyzing water. When these hydrogen molecules dissolve in water, dissolved hydrogen water, which is water to which the first hydrogen is added, is generated.
  • the electrolytic cell 4 includes an electrolytic cell 40, and has a first feeding body 41 and a second feeding body 42 in the electrolytic cell 40.
  • the first feeding body 41 and the second feeding body 42 are provided in the electrolytic chamber 40.
  • a diaphragm 43 is provided between the first feeding body 41 and the second feeding body 42.
  • the electrolytic chamber 40 is divided into a first pole chamber 40a in which the first feeding body 41 is arranged and a second pole chamber 40b in which the second feeding body 42 is arranged by the diaphragm 43.
  • the polarity of the first feeding body 41 and the second feeding body 42 and the voltage applied to the first feeding body 41 and the second feeding body 42 are controlled by the control unit 13.
  • a current detector is provided in the current supply line between the feeding bodies 41 and 42 and the control unit 13.
  • the current detector detects the electrolytic current supplied to the first feeding body 41 and the second feeding body 42, and outputs an electric signal corresponding to the value to the control unit 13.
  • the control unit 13 controls the DC voltage applied to the first feeding body 41 and the second feeding body 42, for example, based on the electric signal output from the current detector. More specifically, the control unit 13 applies a DC voltage to the first feeding body 41 and the second feeding body 42 so that the electrolytic current detected by the current detector becomes a preset desired value. Feedback control. For example, when the electrolytic current is excessive, the control unit 13 reduces the voltage, and when the electrolytic current is too small, the control unit 13 increases the voltage. As a result, the electrolytic current supplied to the first feeding body 41 and the second feeding body 42 is appropriately controlled.
  • Hydrogen gas and oxygen gas are generated by electrolysis of water in the electrolytic chamber 40.
  • hydrogen gas is generated, and dissolved hydrogen water in which the hydrogen molecules are dissolved is generated and supplied to the reverse osmosis membrane module 23 of the reverse osmosis membrane treatment device 2.
  • the dissolved hydrogen water generated by such electrolysis is also referred to as “electrolyzed hydrogen water", and the dialysis treatment using the electrolytic hydrogen water is also referred to as “electrolyzed water dialysis”.
  • oxygen gas is generated in the first electrode chamber 40a on the anode side.
  • a solid polymer membrane made of a fluorine-based resin having a sulfonic acid group is appropriately used.
  • the oxonium ion generated in the first electrode chamber 40a on the anode side is moved to the second electrode chamber 40b on the cathode side by electrolysis, and is used as a raw material for producing hydrogen gas. Therefore, the pH of the dissolved hydrogen water does not change without generating hydroxide ions during electrolysis.
  • control unit 13 is the first feeder so as to increase or decrease the dissolved hydrogen concentration of the dissolved hydrogen water based on the amount of hydrogen gas detected by the detection unit 12 per unit volume of exhaled breath. It is desirable that it is configured to control the current for electrolysis supplied to the 41 and the second feeding body 42.
  • the control unit 13 controls the first power supply body 41 and the second power supply body 42.
  • the current for electrolysis supplied to is largely controlled.
  • the control unit 13 may control the current for electrolysis supplied to the first feeding body 41 and the second feeding body 42 to be small. ..
  • the control unit 13 supplies the first power supply body 41 and the second power supply body 42. It may be configured to largely control the current for electrolysis.
  • the control unit 13 applies a current for electrolysis supplied to the first feeding body 41 and the second feeding body 42. It may be controlled to be small.
  • control unit 13 calculates the current for electrolysis supplied to the first feeding body 41 and the second feeding body 42 based on the combination of the average value and the cumulative value of the amount of hydrogen gas per unit volume of exhaled breath. It may be configured to have great control.
  • FIG. 3 shows a processing procedure of the dissolved hydrogen water generation method 500 used in the present dissolved hydrogen water generation device 1.
  • the dissolved hydrogen water generation method 500 is executed during dialysis treatment using a dialysate to which hydrogen is added, and includes production steps S1, detection steps S21 and S22, and control steps S3, S4 and S5. ..
  • dissolved hydrogen water is generated by the hydrogen water generation unit 3.
  • the production of dissolved hydrogen water will, in principle, continue during the dialysis treatment.
  • the collection unit 11 attached to the mouth of the patient H collects the exhaled breath of the patient H during dialysis.
  • the detection unit 12 detects the hydrogen gas contained in the exhaled breath collected in the detection step S21.
  • the control unit 13 controls the hydrogen water generation unit 3 based on the detection result (presence or absence of hydrogen gas) in the detection step S22. That is, when hydrogen gas is detected in the exhaled breath (Y in S3), it can be determined that the hydrogen gas has reached the body of the patient H, so that the operation of the hydrogen water generation unit 3 is weakened or stopped (S4). For example, in the control step S4, the control unit 13 weakens or cuts off the current for electrolysis.
  • the operation of the hydrogen water generation unit 3 is controlled so as to increase the dissolved hydrogen concentration (S5), and the process returns to S21.
  • the control unit 13 increases the current for electrolysis.
  • dissolved hydrogen water generation method 500 it is possible to appropriately control the production of dissolved hydrogen water used for preparing a dialysate based on the hydrogen delivered to the body of patient H.
  • FIG. 4 shows a dissolved hydrogen water generation method 500A which is a modification of the dissolved hydrogen water generation method 500 of FIG.
  • the treatment procedure of the dissolved hydrogen water generation method 500 described above can be adopted for a portion of the dissolved hydrogen water production method 500A that is not described below.
  • control steps S31 and S32 are applied in addition to the control steps S3, S4 and S5 of the dissolved hydrogen water generation method 500.
  • the control unit 13 calculates the amount of hydrogen gas per unit volume of exhaled breath based on the detection result in the detection step S22, and operates the hydrogen water generation unit 3. To control.
  • control step S31 the control unit 13 calculates the amount of hydrogen gas per unit volume of exhaled breath based on the detection result in the detection step S22. Then, when the amount of hydrogen gas is equal to or greater than the first threshold value (Y in S32), the process proceeds to S4. It may be configured to return to S21 after executing S4.
  • the control unit 13 controls the operation of the hydrogen water generation unit 3 based on the concentration of hydrogen gas in the exhaled breath, so that the generation of the dissolved hydrogen water used for preparing the dialysate is appropriately controlled. It becomes possible to do.
  • FIG. 5 shows a dissolved hydrogen water generation method 500B which is a modification of the dissolved hydrogen water generation method 500A of FIG.
  • the treatment procedure such as the dissolved hydrogen water generation method 500A described above can be adopted.
  • control steps S33 and S34 are applied instead of the control steps S31 and S32 of the dissolved hydrogen water generation method 500A.
  • the control unit 13 calculates the average value of the amount of hydrogen gas per unit volume of exhaled breath based on the detection result in the detection step S22, and the hydrogen water generation unit. Control the operation of 3.
  • control step S33 the control unit 13 calculates the average value of the amount of hydrogen gas per unit volume of exhaled breath based on the detection result in the detection step S22. Then, when the average value of the amount of hydrogen gas is equal to or higher than the second threshold value (Y in S34), the process proceeds to S4. On the other hand, when the average value of the amount of hydrogen gas is smaller than the second threshold value (N in S34), the process shifts to S5 and then returns to S21.
  • the operation of the hydrogen water generation unit 3 is controlled based on the average value of the concentration of hydrogen gas in the exhaled breath, so that it is affected by minute fluctuations in the concentration of the hydrogen gas in the exhaled breath. Instead, it is possible to appropriately control the production of dissolved hydrogen water used in the preparation of dialysate.
  • FIG. 6 shows a dissolved hydrogen water generation method 500C, which is another modification of the dissolved hydrogen water generation method 500A of FIG.
  • the treatment procedure such as the dissolved hydrogen water generation method 500A described above can be adopted.
  • control steps S35 and S36 are applied instead of the control steps S31 and S32 of the dissolved hydrogen water generation method 500A.
  • the control unit 13 calculates the cumulative value of the amount of hydrogen gas per unit volume of exhaled breath based on the detection result in the detection step S22, and the hydrogen water generation unit. Control the operation of 3.
  • control step S35 the control unit 13 calculates the cumulative value of the amount of hydrogen gas based on the detection result in the detection step S22. Then, when the cumulative value of the amount of hydrogen gas is equal to or greater than the third threshold value (Y in S35), the process proceeds to S4. On the other hand, when the cumulative value of the amount of hydrogen gas is smaller than the third threshold value (N in S36), the process shifts to S5 and then returns to S21.
  • the operation of the hydrogen water generation unit 3 is controlled based on the cumulative value of the amount of hydrogen gas, so that the dialysate can be prepared according to the hydrogen gas accumulated in the body of the patient H. It is possible to appropriately control the production of the dissolved hydrogen water used.
  • the present dissolved hydrogen water generator 1 of the present invention is not limited to the above-mentioned specific embodiment, but is modified to various embodiments. That is, the present dissolved hydrogen water generating apparatus 1 is at least an apparatus for generating dissolved hydrogen water in which hydrogen is dissolved in water, and is prepared by a hydrogen water generating unit 3 for generating dissolved hydrogen water and dissolved hydrogen water. To control the hydrogen water generation unit 3 based on the detection unit 12 for detecting the hydrogen gas contained in the exhaled breath of the patient H undergoing dialysis using the dialysate and the detection result of the detection unit 12. It suffices to include the control unit 13 of the above.
  • control unit 13 determines that dialysis is completed when the amount of hydrogen gas or the average value of the amount of hydrogen gas per unit volume of exhaled breath exceeds a predetermined fourth threshold value or fifth threshold value. It may be configured to do so. Further, the control unit 13 may be configured to determine that dialysis has been completed when the cumulative value of the amount of hydrogen gas exceeds a predetermined sixth threshold value.
  • the hydrogen water generation unit 3 is not limited to the electrolytic tank 4 that generates dissolved hydrogen water by electrolyzing water, and for example, hydrogen molecules generated by a chemical reaction between water and magnesium are dissolved in water. It may be an apparatus for generating dissolved hydrogen water, or an apparatus for generating dissolved hydrogen water by dissolving hydrogen gas (hydrogen molecule) supplied from a hydrogen gas cylinder in water.
  • the present dissolved hydrogen water generation method 500 or the like is at least a method for producing dissolved hydrogen water in which hydrogen is dissolved in water, and is prepared by the production step S1 for generating dissolved hydrogen water and the dissolved hydrogen water.
  • S5 and the like may be included.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • External Artificial Organs (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/JP2020/007729 2019-03-27 2020-02-26 溶存水素水生成装置及び溶存水素水生成方法 WO2020195480A1 (ja)

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JP2015177911A (ja) * 2014-03-19 2015-10-08 株式会社日本トリム 透析液の製造装置

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JP5714060B2 (ja) * 2013-06-24 2015-05-07 株式会社日本トリム 透析液調製用水の製造装置
JP5901665B2 (ja) * 2014-01-27 2016-04-13 株式会社日本トリム 透析液調製用水の製造装置
JP5840248B2 (ja) * 2014-03-19 2016-01-06 株式会社日本トリム 透析液の製造装置
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TW202108190A (zh) 2021-03-01
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