WO2020184877A2 - Appareil de circulation de gaz pour test d'inhalation - Google Patents

Appareil de circulation de gaz pour test d'inhalation Download PDF

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Publication number
WO2020184877A2
WO2020184877A2 PCT/KR2020/002930 KR2020002930W WO2020184877A2 WO 2020184877 A2 WO2020184877 A2 WO 2020184877A2 KR 2020002930 W KR2020002930 W KR 2020002930W WO 2020184877 A2 WO2020184877 A2 WO 2020184877A2
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WO
WIPO (PCT)
Prior art keywords
chamber
pipe
circulation
gas
inhalation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2020/002930
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English (en)
Korean (ko)
Other versions
WO2020184877A3 (fr
Inventor
김재영
이주한
정상훈
송승준
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea University Research and Business Foundation
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Korea University Research and Business Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea University Research and Business Foundation filed Critical Korea University Research and Business Foundation
Publication of WO2020184877A2 publication Critical patent/WO2020184877A2/fr
Publication of WO2020184877A3 publication Critical patent/WO2020184877A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Definitions

  • a gas circulation device for an inhalation experiment is disclosed, and more particularly, a gas circulation device in which gas in a chamber is continuously circulated during a toxic inhalation experiment is disclosed.
  • Korean Patent Publication No. 10-1017402 filed on March 17, 2009, discloses "an exposure chamber device for evaluating inhalation toxicity of nanoparticles”.
  • An object according to an embodiment is to provide an apparatus for easily performing an inhalation experiment of fine particles.
  • An object according to an embodiment is to conduct a suction experiment of fine particles at a constant concentration by constantly circulating gas.
  • An object according to an embodiment is to uniformly distribute fine particles used as a sample in the experiment space.
  • An object according to an embodiment is to provide a low-cost, small inhalation experiment apparatus suitable for small animal experiments.
  • An object according to an embodiment is to prevent contamination of the experimenter and the laboratory by configuring a discharge line so that fine particles are not exposed from the experimental apparatus during an experiment.
  • An object according to an embodiment is to reduce the stress of the test subject by creating a living space suitable for the test subject in the test space.
  • An object according to an embodiment is to actively inhale fine particles through the subject's self-breathing.
  • An object according to an embodiment is to prevent consumption of a large amount of sample by inducing circulation of fine particles.
  • An object according to an embodiment is to provide a light and easy-to-clean experimental device.
  • An object according to an embodiment is to configure various flow rates and induce natural suction by controlling the flow of gas by means of an electrical signal.
  • a gas circulation device for an inhalation experiment includes: a chamber in which the test object is accommodated; An input unit for introducing a sample into the chamber; A circulation part to promote circulation of the gas inside the chamber; And a circulation pipe connected to the chamber and the circulation unit so as to communicate with the chamber and the circulation unit, wherein the chamber is rotated to induce environmental changes in the chamber and to induce natural inhalation of the experimental animal.
  • a rotation unit for rotating the chamber, the rotation unit frame for supporting the chamber;
  • a driving member provided on one side of the frame to generate rotational force;
  • a rod extending from a rotational shaft of the driving member and transmitting a rotational force of the driving member to the chamber, and rotating the chamber with the rod as a rotational center by the rotational force of the driving member.
  • the rotating part further includes a fixing ring surrounding the circumference of the chamber, the rod is connected perpendicularly to one surface of the fixing ring, and the fixing ring is disposed in the center of the chamber so that the fixing ring is The chamber can rotate as it rotates.
  • the chamber is formed in a circular capsule shape so that the gas flowing into the chamber may be uniformly distributed.
  • control unit for controlling the air flow rate
  • the control unit may be connected to the circulation unit to control the flow of air in a pulse type.
  • the circulation pipe includes a first pipe having both ends communicating with the other part of the chamber; A second pipe having one end connected to one side of the first pipe and the other end connected to the circulation part; And a third pipe having one end connected to the other side of the first pipe and the other end connected to the circulation part, and may continuously circulate the gas in the chamber through the first pipe.
  • the circulation pipe further includes a fourth pipe whose one end is connected to one side of the first pipe, and the other end of the fourth pipe is connected to the inlet to deliver a sample into the chamber. I can.
  • the gas circulation device for the inhalation experiment there is an effect of providing a device for easily performing the inhalation experiment of fine particles.
  • the gas circulation device for the inhalation experiment there is an effect that the gas is constantly circulated to conduct the inhalation experiment of fine particles at a constant concentration.
  • the gas circulation device for an inhalation experiment there is an effect of preventing contamination of the experimenter and the laboratory by configuring an exhaust line so that fine particles are not exposed from the experiment device during the experiment.
  • the gas circulation device for the inhalation experiment there is an effect of reducing the stress of the specimen by creating a living space suitable for the specimen in the experiment space.
  • the gas circulation device for an inhalation experiment there is an effect of actively inhaling fine particles through self-breathing of the test subject.
  • the gas circulation device for a suction experiment by controlling the flow of gas by an electric signal, there is an effect of configuring various flow rates and inducing natural suction.
  • FIG. 1 is a perspective view of a gas circulation device for an inhalation experiment according to an embodiment.
  • FIG. 2 shows a flow path of gas through a circulation pipe of a gas circulation device for an inhalation experiment according to an embodiment.
  • FIG 3 is a perspective view of a gas circulation device for an inhalation experiment according to an exemplary embodiment showing a chamber mounted on a rotating part.
  • FIG. 4 shows a signal input from a controller of a gas circulation device for an inhalation experiment according to an embodiment.
  • first, second, A, B, (a) and (b) may be used. These terms are only used to distinguish the component from other components, and the nature, order, or order of the component is not limited by the term.
  • FIG. 1 is a perspective view of a gas circulation device 10 for an inhalation experiment according to an embodiment.
  • a gas circulation device 10 for an inhalation experiment may include a chamber 100, an injection unit 200, a circulation unit 300, and a circulation pipe 400.
  • the chamber 100 may be configured to accommodate the test object (S) therein.
  • test object (S) may include small animals for experiments such as, for example, mice, rats, hamsters, and the like.
  • the chamber 100 may also be formed in a circular capsule shape having a size sufficient to accommodate a small animal, and a hole is formed in the upper and lower portions to inject or discharge fine particles into the chamber by being connected to the circulation pipe 400. I can.
  • a portion such as a corner becomes a blind spot, and the distribution of fine particles injected into the chamber may not be uniform. At this time, it may be difficult to see that the test object S moved to the corner portion is under the same experimental conditions as the other test object S.
  • the chamber 100 is configured in a circular shape, the injected fine particles and gas containing the same can be uniformly distributed inside the chamber 100.
  • it since it is configured in a size suitable for small animals, unlike a large chamber, it is light in weight, so it is easy to move and wash after an experiment.
  • the chamber 100 may be formed in a structure capable of opening and closing so that the test object S can be inserted and taken out.
  • a plate on which the test object S can be placed may be placed inside the chamber 100, and a plurality of holes may be formed in the plate.
  • the plurality of holes may be a passage through which gas passes when the gas inside the chamber 100 circulates, and may be a passage through which excrement of the specimen S is discharged.
  • the experimenter (S) can freely live in the chamber 100, and the internal environment of the chamber 100 can be maintained in the chamber 100 for a certain period of time. It can be configured in the same way as the environment. Accordingly, it is possible to reduce the stress of the specimen S, and thus, it is possible to reduce an experimental error that may occur from the difference in the state of each of the specimens S.
  • the injection unit 200 may accommodate a sample to be injected into the chamber 100.
  • one side of the input unit 200 is connected to the circulation pipe 400 to deliver a sample to the chamber 100 through this.
  • the sample may contain fine particles containing toxicity.
  • the input unit 200 receives the toxic fine particles as a sample, the toxic substance is injected into the gas circulation device 10 to evaluate the inhalation toxicity of the fine particles.
  • the circulation unit 300 may induce continuous circulation of the gas inside the chamber 100.
  • the circulation unit 300 may be provided as a circulation pump to form a negative pressure inside the chamber 100.
  • the circulation unit 300 may further include additional pipes at both ends. If necessary, before or after the experiment is completed, the gas inside the gas circulation device 10 is discharged to the gas circulation device 10 or the outside of the laboratory, or the gas outside the laboratory or laboratory is inside the gas circulation device 10 It is to make it flow into.
  • the paths through which gas is introduced into or discharged from the inside of the gas circulation device 10 are separated respectively and passed directly to the outside. It is possible to prevent the above-described problems from occurring due to the gas circulation device 10 by providing a separate path.
  • the circulation pipes 400 may be respectively connected to holes provided in the upper and lower portions of the chamber 100 to communicate with the chamber 100. In addition, it may be connected to the chamber 100 and the circulation unit 300 so as to communicate the chamber 100 and the circulation unit 300.
  • FIG. 2 shows a flow path of gas through the circulation pipe 400 of the gas circulation device 10 for an inhalation experiment according to an embodiment.
  • the circulation pipe 400 of the gas circulation device 10 for the inhalation experiment includes a first pipe 410, a second pipe 420, a third pipe 430, and a third pipe. It may include 4 pipes 440.
  • Both ends of the first pipe 410 may communicate with different portions of the chamber 100. Specifically, both ends of the first pipe 410 may be connected to holes provided in the upper and lower portions of the chamber 100 for inflow or discharge of gas and samples.
  • One end of the second pipe 420 may be connected to one side of the first pipe 410 and the other end may be connected to the circulation unit 300.
  • the second pipe 420 may be a passage for communicating the circulation unit 300 with one end of the first pipe 410 connected to the upper portion of the chamber 100. Accordingly, the gas in the chamber 100 may flow along the arrow direction of the second pipe 420 by the pressure of the circulation unit 300, or an external gas such as air may be introduced to flow.
  • the third pipe 430 may have one end connected to the other side of the first pipe 410 and the other end connected to the circulation unit 300.
  • the third pipe 430 may be a passage for communicating the other end of the first pipe 410 connected to the lower portion of the chamber 100 and the circulation unit 300. Accordingly, the gas in the chamber 100 may flow along the arrow direction of the third pipe 430 due to the pressure of the circulation unit 300 or the gas inside the chamber 100 may be discharged to the outside.
  • One end of the fourth pipe 440 may be connected to one side of the first pipe 410 and the other end may be connected to the input unit 200.
  • the fourth pipe 440 may be a passage for communicating the input unit 200 with one end of the first pipe 410 connected to the upper portion of the chamber 100.
  • a negative pressure is generated by the circulation unit 300, and accordingly, the sample accommodated in the input unit 200 is inside the chamber 100 through the fourth pipe 440 in the direction of the arrow.
  • gas and a sample flow into the chamber 100 through the second pipe 420 and the fourth pipe 440 and to the outside of the chamber 100 through the third pipe 430. It can flow.
  • the first pipe 410 is provided to connect the inlet hole and the outlet hole of the chamber 100 to induce a gas and a sample exiting the chamber to flow back into the chamber 100. Accordingly, since the gas in the chamber 100 can be continuously circulated, the sample is also not accumulated or concentrated in a specific portion, but continues to flow in the chamber 100 and can be distributed at a constant concentration in any portion. Therefore, the test object S accommodated in the chamber 100 can actively inhale samples and gases uniformly distributed through self-breathing. In addition, by inducing the circulation of the sample, it is possible to facilitate supply of a certain amount of sample and prevent consumption of a large amount of sample.
  • FIG 3 is a perspective view of a gas circulation device 10 for an inhalation experiment according to an embodiment showing a state in which the chamber 100 is mounted on the rotating part 500.
  • the gas circulation device 10 for an inhalation experiment may further include a rotating part 500.
  • the rotating unit 500 may rotate the chamber 100 to induce a change in the environment inside the chamber 100.
  • the rotating part 500 may be composed of a frame 510, a driving member 520, a rod 530, and a fixing ring 540.
  • the frame 510 may support the chamber 100.
  • the frame 510 may include a horizontal frame formed flat to contact the ground and a vertical frame vertically attached to the horizontal frame and extending in a longitudinal direction.
  • the horizontal frame and the vertical frame may have a sufficient area and weight so that the chamber 100 does not shake even if motion such as rotation of the chamber 100 or the movement of the test object S inside the chamber 100 occurs.
  • the driving member 520 may generate rotational force.
  • the driving member 520 may be provided as a stepping motor and may be fixed to one side of the vertical frame.
  • the driving member 520 may be provided to be perpendicular to the longitudinal direction of the vertical frame of the rotation axis of the driving member 520.
  • the rotation range of the driving member 520 may be set to 180 degrees.
  • the rod 530 may be provided with one end rotatably fixed at one side of the vertical frame and connected to the rotation shaft of the driving member 520 to extend in the same direction as the axial direction of the rotation shaft. Accordingly, the rotational force generated by the driving member 520 may rotate the rod 530 connected thereto along the rotation axis. In addition, since the other end of the rod 530 is attached to the fixing ring 540, the fixing ring 540 may also be rotated according to the rotation of the rod 530.
  • the fixing ring 540 has a ring shape having a center penetrating it and extends slightly in a direction perpendicular to the circumferential direction to wrap around the circumference of the chamber 100.
  • the rod 530 may extend from the vertical frame and be vertically attached to one surface of the fixing ring 540. At this time, since the rod 530 is not rotatably connected to one surface of the fixing ring 540, the fixing ring 540 may rotate together with the rotation of the rod 530. In addition, since the fixed ring 540 is disposed in the center of the chamber 100 to fix the chamber 100, the rod 530 becomes a rotational center axis of the chamber 100, and as the fixing ring 540 rotates Chamber 100 can also rotate.
  • the chamber 100 fixed on the frame 510 by the fixing ring 540 may be rotated within a range of 180 degrees with the rod 530 as a rotational force by the rotational force of the driving member 520.
  • This structure enables the inhalation experiment of the test object S in various environments by injecting gas into the chamber 100 at various angles. In addition, it is easy to induce natural inhalation of the sample because it induces breathing of the specimen (S).
  • FIG. 4 shows a signal input from a controller of a gas circulation device for an inhalation experiment according to an embodiment.
  • the gas circulation device 10 for an inhalation experiment may further include a control unit (not shown).
  • the control unit may be connected to the circulation unit 300 and may control the flow rate of gas flowing into or out of the chamber 100.
  • the controller may control the gas inside the chamber 100 to pulse type flow by generating a constant repetitive load pattern to the circulation unit 300.
  • the gas circulation device 10 for the inhalation experiment changes the input signal for generating the repetitive load pattern from the control unit, such as the duty cycle showing different aspects in FIG. Since the gas can be configured with various flow rates such as wind speed, more natural inhalation experiments are possible. In addition, since the pulse-type gas flow can control the scattering of fine particles like a natural wind, it is easy to induce inhalation of fine particles through natural breathing for the specimen (S).

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Abstract

L'invention concerne un appareil de circulation de gaz pour un test d'inhalation selon un mode de réalisation et comprend : une chambre destinée à recevoir un sujet de test ; une partie d'introduction permettant d'introduire un échantillon dans la chambre ; une partie de circulation permettant de favoriser la circulation d'un gaz à l'intérieur de la chambre ; et un tuyau de circulation relié à la chambre et à la partie de circulation de façon à communiquer avec la chambre et la partie de circulation, la chambre pouvant tourner de façon à induire un changement dans l'environnement à l'intérieur de la chambre et à induire une inhalation naturelle chez un animal de laboratoire.
PCT/KR2020/002930 2019-03-14 2020-03-02 Appareil de circulation de gaz pour test d'inhalation Ceased WO2020184877A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0029290 2019-03-14
KR1020190029290A KR102201941B1 (ko) 2019-03-14 2019-03-14 흡입 실험을 위한 기체 순환 장치

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WO2020184877A2 true WO2020184877A2 (fr) 2020-09-17
WO2020184877A3 WO2020184877A3 (fr) 2020-11-05

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115414153A (zh) * 2022-09-05 2022-12-02 中国人民解放军海军特色医学中心 一种舱内实验动物烟气吸入染毒及加压模拟系统
CN117136857A (zh) * 2023-10-23 2023-12-01 佳木斯大学 一种小动物呼吸实验用采样装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5091889B2 (ja) * 2009-02-27 2012-12-05 三菱重工業株式会社 動物固定装置及び動物固定方法
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
CN102138832A (zh) * 2011-03-25 2011-08-03 天津开发区合普工贸有限公司 氡气暴露染毒实验设备
KR20150083551A (ko) * 2014-01-10 2015-07-20 김제원 미세 입자 흡입 실험용 챔버 및 이를 구비한 실험 장치
KR101841329B1 (ko) * 2015-12-11 2018-03-23 한양대학교 산학협력단 실험장치 및 이를 이용한 실험방법

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115414153A (zh) * 2022-09-05 2022-12-02 中国人民解放军海军特色医学中心 一种舱内实验动物烟气吸入染毒及加压模拟系统
CN117136857A (zh) * 2023-10-23 2023-12-01 佳木斯大学 一种小动物呼吸实验用采样装置
CN117136857B (zh) * 2023-10-23 2024-01-09 佳木斯大学 一种小动物呼吸实验用采样装置

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KR20200109741A (ko) 2020-09-23
WO2020184877A3 (fr) 2020-11-05

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