WO2020154934A1 - Localisateur d'assistant d'opération - Google Patents

Localisateur d'assistant d'opération Download PDF

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Publication number
WO2020154934A1
WO2020154934A1 PCT/CN2019/073801 CN2019073801W WO2020154934A1 WO 2020154934 A1 WO2020154934 A1 WO 2020154934A1 CN 2019073801 W CN2019073801 W CN 2019073801W WO 2020154934 A1 WO2020154934 A1 WO 2020154934A1
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WO
WIPO (PCT)
Prior art keywords
surgical
shell
positioner according
tumor
positioning
Prior art date
Application number
PCT/CN2019/073801
Other languages
English (en)
Chinese (zh)
Inventor
王长利
陈玉龙
颜博
胡万宁
刘浩源
郑瑞云
赵晓亮
张真发
张连民
庞冲
王晟广
朱建权
孙晓燕
Original Assignee
唐山哈船科技有限公司
天津市肿瘤医院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 唐山哈船科技有限公司, 天津市肿瘤医院 filed Critical 唐山哈船科技有限公司
Priority to PCT/CN2019/073801 priority Critical patent/WO2020154934A1/fr
Priority to AU2019100779A priority patent/AU2019100779A4/en
Publication of WO2020154934A1 publication Critical patent/WO2020154934A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges

Definitions

  • the invention relates to the technical field of surgical auxiliary equipment, in particular to a surgical auxiliary locator.
  • Tumors refer to new organisms formed by the proliferation of local tissue cells under the action of various tumor-causing factors; tumors are roughly divided into benign tumors and malignant tumors (i.e. cancer). Benign tumors are usually removed by surgery, and malignant tumors are treated comprehensively. If it is necessary to combine radiotherapy and chemotherapy, in order to greatly increase the cure rate and improve the quality of life of patients.
  • the location of the tumor is usually performed by CT, but during the surgical resection, the corresponding tissue is not fixed, such as a lung tumor. After the breathing device is inserted, the lung will collapse. The position of the preoperative positioning will change, and the collapsed lungs will make the repositioning very time-consuming, affecting the operation, delaying the operation time, causing pain to the patient and putting pressure on the doctor.
  • the present invention proposes a surgical auxiliary locator, which is conveniently placed near the tumor and assists in accurately positioning the tumor position.
  • a surgical auxiliary positioner comprising an expandable compression body and a positioning body, the compression body covering the positioning body.
  • the shell also includes a shell which covers the compressed body; the shell ablates after being in contact with body fluids for 5-10 minutes.
  • compression body and the positioning body are an integral structure.
  • the compressed body is made of swelling material, and the volume expands by 5 to 10 times after being in contact with body fluid for 5 seconds to 30 minutes.
  • the compressed body is an elastic metal wire ball.
  • the positioning body is made of magnetic metal material.
  • the shell is ribbon-shaped and binds the compression body.
  • the swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar, or polysaccharide hydrogel.
  • the shell is made of gelatin or starch.
  • the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated.
  • an expandable compression body is used to cover the positioning body, and it is delivered to the vicinity of the tumor before the operation. Even if the collapse occurs during the operation, the compression body will expand, and the positioning experience will be easy Being detected, it is convenient for doctors to quickly find the location of the tumor, reduce the operation time, relieve the patient's pain and the doctor's surgical pressure and workload.
  • the product of the present invention can be coated with a layer of shell structure.
  • the shell covers the compressed body to prevent the compressed body from expanding.
  • the shell itself is made of ablative material and inserted into the vicinity of the tumor. After contact with body fluids, the shell ablates and the compressed body begins to expand. .
  • the whole product can be made into a shape that can be inserted into the vicinity of the tumor through a hollow needle, it will not cause too much pain to the patient before the operation, and it is accurate and reliable.
  • the structure of the whole product is ingenious, and it is convenient and fast to be inserted before the operation, which is helpful for accurate positioning during the operation, saving operation time and reducing the removal of normal tissues.
  • Fig. 1 is a schematic diagram of the structure of the surgical auxiliary positioner of the present invention
  • Figure 2 is a schematic diagram of the compressed body after expansion
  • Figure 3 is a schematic diagram of another structure of the present invention.
  • Figure 4 is a third structural diagram of the present invention.
  • the operation auxiliary locator of the present invention is an auxiliary device suitable for being placed near the tumor before operation, and convenient for detecting and accurately determining the position of the tumor during operation.
  • the surgical auxiliary positioner includes an expandable compression body 1 and a positioning body 2, and the compression body 1 covers the positioning body 2.
  • the compressed body 1 is in a compressed state, and is covered with a positioning body 2 inside, and is sent to the vicinity of the tumor before the operation, especially when at least three surgical auxiliary positioners are placed near the tumor.
  • auxiliary surgical locator Because the volume of the auxiliary surgical locator itself is small, it can be inserted by hollow needle injection, and three or more auxiliary surgical locators can easily locate the tumor.
  • the compression body 1 will automatically expand after being inserted into the vicinity of the tumor. Even for the lungs that collapsed during the operation, the expansion makes the tumor position more obvious; at the same time, the positioning body 2 is wrapped in the expanded compression body, and the instrument can also be used (Such as CT) detection and positioning, so that the position determination is more accurate, and it is convenient for the doctor to quickly find the tumor and perform the resection, which reduces the patient's operation time and greatly reduces the pressure during the operation of the doctor.
  • a surgical auxiliary positioner is composed of an outer compressed body 1 and an inner positioning body 2.
  • the compressed body 1 is made of swelling material and has a small volume before being in contact with liquid. Cover the positioning body 2 and inject the hollow needle into the vicinity of the tumor.
  • the swelling material absorbs body fluids and expands and changes in volume, as shown in Figure 2.
  • the swelling material As to how long the body fluids contact with body fluids, and how large the volume expands, it can be selected according to different swelling materials and surgical needs; Generally, it is set to expand by 5 to 10 times after being in contact with body fluids for 5 seconds to 30 minutes to meet the needs of surgery.
  • the swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar, or polysaccharide hydrogel.
  • the above substances are all conventional swelling materials, that is, they can increase in volume after absorbing water.
  • the compression body 1 After the compression body 1 increases in volume, it can squeeze the surrounding tissues to be more firmly positioned beside the tumor. Even if the tissue beside the tumor changes, such as collapse, the compressed body 1 will not change after expansion, so it is relatively The positioning information is more reliable. In particular, there are multiple compressed bodies 1 distributed near the tumor, such as the front, back, left, right, upper, and lower positions of the tumor, and the positioning accuracy will be very high.
  • the position of the positioning body 2 can be determined by instrument detection, so that the approximate position of the tumor can be accurately known on the detection instrument, and the tumor and all the tissues of the compression body 1 can be directly integrated during the operation Resection ensures the completeness of the tumor removal, and there will be no remaining problems without complete removal.
  • CT Traditional CT can be used for instrument detection. Because CT is sensitive to metal, the positioning body 2 here is made of metal, so the CT detection is very easy to determine the position of the positioning body 2.
  • the positioning body 2 itself can be in the shape of particles, wires, sheets, etc. made of metal, which can achieve the above positioning effect.
  • the shape of the auxiliary surgical locator is spindle-shaped. Since the hollow needle is used for injection, the maximum outer diameter is set to 0.5-5 mm. The size of the auxiliary surgical locator is selected according to the tumor size.
  • the surgical assist positioner shown in Fig. 3 is compared with Example 1.
  • the compression body 1 is covered with a shell 3, and the shell 3 is ablated after being in contact with body fluids for 5-10 minutes.
  • the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated, and is used to mark the location of the tissue.
  • a tracer for example, nuclides, methylene blue and nanocarbons.
  • the positron annihilation produced during the decay process of the radionuclide is subjected to electronic detection and computer reconstruction imaging, so that we can obtain human metabolism or functional images.
  • a shell 3 is provided outside the compression body 1 to suspend the expansion of the compression body 1; the compression body 1 can only be expanded when the shell 3 ablates to the extent that the compression body 1 cannot be restricted.
  • the structure of adding the outer shell 3 outside the compression body 1 can reduce the patient's pain after the hollow needle is injected into the positioner, and avoid the damage to the patient caused by the rapid expansion of the compression body 1 immediately after the injection.
  • the compressed body 1 is not only limited to an expansion material, but can also be made of an elastic material or other expandable materials.
  • the shell 3 temporarily restricts the expansion of the compressed body 1. As shown in FIG. 3, the shell 3 is fully enclosed to cover the compressed body 1. At this time, the compressed body 1 is made of swelling material to avoid the shell 3 Without ablation to a certain extent, the compression body 1 begins to expand.
  • a covering that can limit the expansion of the compression body 1 at the key position can be used, such as a compression body made of elastic material, and the outer shell 3 is set in a linear shape, and the compression body 1 to be expanded can be wound around.
  • the outer shell 3 is made of gelatin or starch, etc., after being in contact with body fluids, it will gradually melt and cause no harm to the human body.
  • a surgical auxiliary positioner As shown in Figure 4, a surgical auxiliary positioner. Compared with the product in Example 1, the compression body 1 and the positioning body 2 are integrated, which is equivalent to the positioning body 2 with expansion function, or the compression body 1 with positioning function. Such as the compressed metal wire ball.
  • a tiny compressed metal wire ball is injected into the vicinity of the tumor through a hollow needle, and it immediately expands to form an expanded locator; a shell 3 can also be added outside the compression body 1, as shown in Figure 4. After injection, the shell 3 will ablate to a certain extent After the degree, the metal wire ball expands.
  • the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated, and is used to mark the location of the tissue. For example, nuclides, methylene blue and nanocarbons.
  • the annihilation of the positron generated during the decay process of the radionuclide is carried out through electronic detection and computer reconstruction imaging, so that we can obtain human metabolism or functional images.
  • the shell 3 can be made into a ribbon shape, and the metal wire ball can be tied up. When the ribbon-shaped shell 3 contacts the body fluid, ablation occurs until the metal wire ball expands.
  • the shell 3 can be set in a spindle shape, a round ball or other shapes convenient for injection.
  • the positioning body 2 is made of metal, and can also be made of magnetic metal materials, such as iron-cobalt, nickel and their alloys. It is convenient to use magnetic detection equipment to detect the instrument, so as to avoid the metal itself in the operation. interference.
  • the surgical auxiliary locator of the present invention passes through a hollow needle before the operation, taking lung tumor resection as an example, and is placed next to the tumor in the lung. After the breathing device is inserted during the operation, the lung collapse becomes very small, and the original tumor is not easy to locate and remove.
  • the surgical auxiliary locator placed next to the tumor can accurately locate the tumor and perform resection. After resection, the tumor can also be found with the aid of the surgical auxiliary locator (in traditional operations, it is difficult to find the tumor in the cut tissue, and even CT is difficult) , Do rapid pathology, reduce operation time, protect patients, and reduce the workload of doctors.
  • the surgical auxiliary positioner of the present invention adopts a combined structure of an expandable compression body (containing a positioning body) that is easily ablated by body fluids, which is clever in structure and convenient to operate.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention concerne un localisateur d'assistant d'opération, comprenant un corps de compression extensible et un corps de positionnement, le corps de compression recouvrant le corps de positionnement. Le produit entier de la présente invention a une structure ingénieuse, est placé avant une opération, est pratique et rapide à utiliser, et contribue à une localisation précise pendant l'opération, de telle sorte que le temps d'opération est raccourci, et la possibilité d'exciser un tissu normal est réduite.
PCT/CN2019/073801 2019-01-30 2019-01-30 Localisateur d'assistant d'opération WO2020154934A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2019/073801 WO2020154934A1 (fr) 2019-01-30 2019-01-30 Localisateur d'assistant d'opération
AU2019100779A AU2019100779A4 (en) 2019-01-30 2019-07-18 Surgical locator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/073801 WO2020154934A1 (fr) 2019-01-30 2019-01-30 Localisateur d'assistant d'opération

Publications (1)

Publication Number Publication Date
WO2020154934A1 true WO2020154934A1 (fr) 2020-08-06

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PCT/CN2019/073801 WO2020154934A1 (fr) 2019-01-30 2019-01-30 Localisateur d'assistant d'opération

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AU (1) AU2019100779A4 (fr)
WO (1) WO2020154934A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1672630A (zh) * 2004-03-26 2005-09-28 埃色康内外科股份有限公司 标记物组织的设备和方法
US20110105895A1 (en) * 2009-10-01 2011-05-05 Giora Kornblau Guided surgery
CN107920865A (zh) * 2015-06-04 2018-04-17 安都磁学有限公司 用于磁标记定位（mml）的标记材料和形式

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1672630A (zh) * 2004-03-26 2005-09-28 埃色康内外科股份有限公司 标记物组织的设备和方法
US20110105895A1 (en) * 2009-10-01 2011-05-05 Giora Kornblau Guided surgery
CN107920865A (zh) * 2015-06-04 2018-04-17 安都磁学有限公司 用于磁标记定位（mml）的标记材料和形式

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AU2019100779A4 (en) 2019-08-15

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