WO2020147173A1 - Dispositif et système de test de salive - Google Patents

Dispositif et système de test de salive Download PDF

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Publication number
WO2020147173A1
WO2020147173A1 PCT/CN2019/077051 CN2019077051W WO2020147173A1 WO 2020147173 A1 WO2020147173 A1 WO 2020147173A1 CN 2019077051 W CN2019077051 W CN 2019077051W WO 2020147173 A1 WO2020147173 A1 WO 2020147173A1
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WIPO (PCT)
Prior art keywords
connector
detection
saliva
voltage
resistor
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PCT/CN2019/077051
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English (en)
Chinese (zh)
Inventor
罗国发
刘洪涛
张文瑶
李浪
刘建兵
龚梅军
Original Assignee
深圳和而泰数据资源与云技术有限公司
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Publication of WO2020147173A1 publication Critical patent/WO2020147173A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units

Definitions

  • This application relates to the field of home medical technology, and more specifically, to a saliva detection device and system.
  • Saliva is a complex mixture that not only contains various proteins, but also DNA, RNA, fatty acids and various microorganisms. Studies have found that various protein components in the blood are also present in saliva, and saliva can reflect changes in the levels of various proteins in the blood. Therefore, it is possible to diagnose diseases through saliva detection.
  • saliva testing can be performed in a variety of environments (including on the roadside) and provide valuable diagnostic information.
  • saliva has been used for the detection of HIV, HBV, and various drugs (such as cocaine and alcohol).
  • drugs such as cocaine and alcohol.
  • a saliva detection device includes:
  • Detection chip used to detect saliva to obtain saliva detection data
  • the first connector is fixedly connected to the detection chip
  • a detection board which includes a second connector and a microcontroller that are plug-in-connected with the first connector;
  • the microcontroller is electrically connected to the second connector, and is used to obtain the saliva detection data.
  • the first connector is a USB Type-C male connector; the second connector is a USB Type-C female connector.
  • the first connector and the second connector communicate according to a first preset communication protocol.
  • the first connector is a male lightning connector; the second connector is a female lightning connector.
  • the first connector and the second connector communicate according to a second preset communication protocol.
  • the detection board further includes:
  • a wireless communication device where the microcontroller performs data interaction with a host device through the wireless communication device.
  • the detection board further includes:
  • a voltage stabilization protection circuit the micro battery is electrically connected to the second connector through the voltage stabilization protection circuit.
  • the voltage stabilization protection circuit includes:
  • a voltage stabilizer the input end of the voltage stabilizer is electrically connected to the micro battery, and the first output end of the voltage stabilizer is grounded;
  • a current-limiting component the input end of the current-limiting component is electrically connected to the second output end of the voltage regulator, and the output end of the current-limiting component is electrically connected to the second connector.
  • the current limiting component includes:
  • a current-limiting resistor one end of the current-limiting resistor is electrically connected to the second output terminal of the voltage regulator;
  • a diode, the anode of the diode is electrically connected to the other end of the current limiting resistor, and the cathode of the diode is electrically connected to the second connector.
  • the second connector includes:
  • the first detection pin is grounded through the first resistor and used to detect the level of the first on-voltage of the first resistor
  • the second detection pin is grounded through the second resistor and used to detect the level of the second conduction voltage of the second resistor.
  • the microcontroller determines whether the voltage between the first connector and the second connector is based on the level of the first turn-on voltage and the second turn-on voltage. Insertion direction is forward insertion or reverse insertion;
  • the first connector and the second connector are inserted in the forward direction
  • the first connector and the second connector are reversely inserted.
  • the microcontroller is further configured to determine whether the first connector is inserted into the second connection according to the level of the first turn-on voltage and the second turn-on voltage Device
  • the first connector is not connected to the second connector.
  • the detection wafer is a nano sensor.
  • a saliva detection device includes:
  • Detection chip used to detect saliva to obtain saliva detection data
  • the first connector is fixedly connected to the detection chip
  • a detection board includes a second connector plug-in connection with the first connector, a microcontroller and a wireless communication device; wherein,
  • the second connector includes a first detection pin and a second detection pin.
  • the first detection pin is grounded through a first resistor and is used to detect the level of the first conduction voltage of the first resistor
  • the second detection pin is grounded through a second resistor, and is used to detect the level of the second conduction voltage of the second resistor;
  • the microcontroller is electrically connected to the second connector, and is configured to determine whether the first connector is connected to the second connector according to the level of the first conduction voltage and the second conduction voltage. For the insertion direction between the two connectors, the microcontroller is also used to obtain the saliva detection data, and perform data interaction with the host device through the wireless communication device.
  • a saliva detection system includes a saliva detection device and host equipment; wherein, the saliva detection device includes:
  • Detection chip used to detect saliva to obtain saliva detection data
  • the first connector is fixedly connected to the detection chip
  • a detection board comprising a second connector and a microcontroller that are plug-in connection with the first connector;
  • the microcontroller is electrically connected to the second connector, and is used to obtain the saliva detection data and perform data interaction with the host device.
  • the second connector includes a first detection pin and a second detection pin.
  • the first detection pin is grounded through a first resistor and is used to detect the first resistance of the first resistor.
  • the second detection pin is grounded through a second resistor, and is used to detect the level of the second conduction voltage of the second resistor;
  • the microcontroller is electrically connected to the second connector, and is configured to determine whether the first connector is connected to the second connector according to the level of the first conduction voltage and the second conduction voltage. The direction of insertion between the two connectors.
  • the above saliva detection device adopts a separate design for the detection chip and the detection plate, and through the cooperation of the first connector and the second connector, the saliva can be Substance detection is not only easy to operate, but also can be used in any place, with the advantage of strong adaptability.
  • the saliva detection device of the present application has the advantages of small size, simple structure, convenient carrying, and low cost.
  • FIG. 1 is a structural block diagram of a saliva detection device provided by an embodiment of the application
  • FIG. 2 is a schematic diagram of the structure of a detection board provided by an embodiment of the application.
  • FIG. 3 is a schematic diagram of the structure of a detection chip and a first connector provided by an embodiment of the application;
  • FIG. 4 is a schematic diagram of a pin structure of a second connector provided by an embodiment of the application.
  • FIG. 5 is a schematic diagram of the structure of a current channel, a first diode, and a second diode provided by an embodiment of the application;
  • FIG. 6 is a schematic diagram of a partial circuit of a saliva detection device provided by an embodiment of the application.
  • FIG. 7 is a circuit block diagram of a saliva detection device provided by an embodiment of the application.
  • an embodiment of the present application provides a saliva detection device 10 including a detection chip 100, a first connector 110 and a detection board 200.
  • the detection chip 100 is used to detect saliva to obtain saliva detection data.
  • the first connector 110 is fixedly connected to the detection chip 100.
  • the detection board 200 includes a second connector 210 and a microcontroller 220 that are plug-in connection with the first connector 110.
  • the microcontroller 220 is electrically connected to the second connector 210.
  • the microcontroller 220 is used to obtain the saliva detection data of the detection chip 100.
  • the shape of the detection wafer 100 is not limited, as long as it can be put in the mouth to detect saliva.
  • the shape of the detection wafer 100 may be a long flat shape.
  • the shape of the detection wafer 100 can also be designed to fit into the mouth, so that the detection wafer 100 can contact the saliva in the mouth, so that the detection wafer 100 can fully contact the saliva.
  • the parts of the detection wafer 100 that are in contact with the oral cavity of the human body are required to be non-toxic, harmless, and tasteless.
  • the edge of the detection wafer 100 is designed to be smooth and rounded so as not to scratch the oral cavity.
  • saliva may also be dropped on the detection wafer 100 outside the body, which can reduce the requirement for the harmlessness of the material of the detection wafer 100.
  • the specific structure of the detection wafer 100 is not specifically limited, as long as the detection wafer 100 has the function of detecting saliva.
  • the specific structure of the inspection wafer 100 can be selected according to actual needs.
  • the detection wafer 100 may be a nano sensor 101.
  • the nanosensor 101 may include 5 detection channels, which can detect different virus surface proteins and genetic material sequences, such as small molecules, proteins, viruses, and bacteria. Different concentrations of the tested substance will change the channel current. The range is 0-1000uA, and the typical value is 100uA.
  • the back-end circuit that is, the detection board 200 detects the magnitude of the current again to calculate the concentration of the substance to be tested.
  • the test wafer 100 is produced using a standard wafer process.
  • the inspection wafer 100 is provided with five inspection channels, and a maximum of 5 results can be obtained in one test, which has the characteristic of strong applicability.
  • each channel is time-division multiplexed, and only one channel is gated and measured at the same time.
  • first connector 110 is fixedly connected to the detection chip 100 is not limited, as long as the first connector 110 and the detection chip 100 are fixedly secured.
  • first connector 110 and the detection chip 100 are welded and fixed in a high temperature environment.
  • the specific structures of the first connector 110 and the second connector 210 are not specifically limited, as long as the data communication between the first connector 110 and the second connector 210 is ensured OK.
  • the specific structures of the first connector 110 and the second connector 210 can be selected according to actual needs.
  • the first connector 110 may be a male connector of a USB connector
  • the second connector 210 may be a female connector of a USB connector.
  • the first connector 110 may be a male connector of an HDMI (High Definition Multimedia Interface) connector
  • the second connector 210 may be a female connector of an HDMI connector.
  • the microcontroller 220 may be an MCU (micro control unit or single-chip microcomputer) with integrated NFC (Near Field Communication, near field communication) function.
  • the MCU can be powered by the NFC coil 231, and no other power supply is needed.
  • the microcontroller 220 may also be another integrated chip with detection and control functions. Due to the small size of the microcontroller 220, the overall volume of the detection board 200 can be greatly reduced, thereby facilitating carrying around.
  • the detection board 200 further includes a wireless communication device 230.
  • the microcontroller 220 exchanges data with the host device 300 through the wireless communication device 230.
  • the communication mode of the wireless communication device 230 is not limited, as long as it has a wireless communication function.
  • the communication mode of the wireless communication device 230 may be Bluetooth.
  • the communication mode of the wireless communication device 230 may also be WIFI.
  • the communication mode of the wireless communication device 230 may also be a radio frequency signal.
  • the wireless communication device 230 can realize data interaction between the microcontroller 220 and the host device 320.
  • the second connector 210 and the first connector 110 can be inserted in the front and back.
  • the second connector 210 includes a first detection pin 211 and a second detection pin 213.
  • the microcontroller 220 is used to detect whether the second connector 210 is inserted into the first connector 110. In an embodiment, when the microcontroller 220 detects that the voltages of the first detection pin 211 and the second detection pin 213 in the second connector 210 are both low, it is described The first connector 110 is not inserted into the second connector 210 or the first connector 110 and the second connector 210 are not firmly inserted. In this way, it can be determined whether the second connector 210 is inserted into the first connector 110, which increases the reliability of use.
  • the microcontroller 220 obtains the inspection data of the inspection wafer 100 through the cooperative use of the first connector 110 and the second connector 210, and uses the wireless communication device 230 Send to the host device 300.
  • the host device 300 may be a mobile phone or a tablet, etc., through which the detection data is displayed and stored in a background database for long-term monitoring.
  • the detection wafer 100 and the detection board 200 adopt a separate design, and through the cooperation of the first connector 110 and the second connector 210, the detection of saliva substances can be completed , Not only easy to operate, but also can be used in any place, with the advantage of strong adaptability.
  • this embodiment has the advantages of small size, simple structure, convenient carrying and low cost.
  • the first detection pin 211 of the second connector 210 is grounded through a first resistor 212.
  • the first detection pin 211 is used to detect the level of the first turn-on voltage of the first resistor 212.
  • the second detection pin 213 in the second connector 210 is grounded through a second resistor 214.
  • the second detection pin 213 is used to detect the level of the second conduction voltage of the second resistor 214.
  • the microcontroller 220 determines whether the first connector 110 and the second connector 210 are based on the level of the first turn-on voltage and the second turn-on voltage.
  • the direction of insertion between is forward insertion or reverse insertion. If the first turn-on voltage is at a high level and the second turn-on voltage is at a low level, the first connector 110 and the second connector 210 are inserted in the forward direction. If the first turn-on voltage is at a low level and the second turn-on voltage is at a high level, the first connector 110 and the second connector 210 are reversely inserted.
  • the positions of the first detection pin 211 and the second detection pin 213 in the second connector 210 can be set according to actual needs. According to the level of the first turn-on voltage and the second turn-on voltage, it can be determined whether the insertion direction between the first connector 110 and the second connector 210 is forward or reverse. Insert, has the advantage of convenient use.
  • the first connector 110 is a USB Type-C male connector.
  • the second connector 210 is a USB Type-C female connector.
  • the board thickness of the USB Type-C terminals ie, USB Type-C male and female
  • the height of the USB Type-C female can be set at 1-3 mm, which can realize the card design, so that the saliva detection device 10 is easy to carry.
  • the first connector 110 and the second connector 210 communicate according to a first preset communication protocol.
  • the first preset communication protocol may be a standard protocol of the USB Type-C terminal.
  • the first preset communication protocol may also be a customized communication protocol of the USB Type-C terminal, as long as it can realize the communication between the first connector 110 and the second connector 210. It is sufficient to ensure that the USB Type-C terminal adopting a standard protocol will not damage the detection board 200 when inserted into the second connector 210.
  • the customized communication protocol of the USB Type-C terminal may be as shown in the following table:
  • the list of female header pins is as follows:
  • the list of male pins is as follows:
  • the positions and numbers of the power pins Vchip and the ground pins GND of the USB Type-C male and USB Type-C female connectors are maintained, and the voltage of the power pin Vchip is maintained at 1V.
  • the five current channels in the USB Type-C male header and the USB Type-C female header are OUT1-5, respectively, and are placed in flipped symmetrical positions.
  • the USB Type-C male connector is connected to Vchip at position A8, and the detected pins in the USB Type-C female connector are CC1 (that is, the first detection pin 211) and CC2 (that is, the second detection pin). 213), these two pins are connected to 100K resistance to ground.
  • the number of the current channels can be selected according to actual needs, and is not limited to 5, and can also be 8 or 12, and so on.
  • CC1 and CC2 are both low, it means that the first connector 110 is not inserted into the second connector 210, that is, the inspection chip 100 is not inserted into the inspection board 200;
  • CC1 detects a high level and CC2 detects a low level, it indicates that the first connector 110 is being inserted into the second connector 210, that is, the inspection chip 100 is being inserted into the inspection board 200;
  • CC2 detects a high level and CC1 detects a low level, indicating that the first connector 110 is inserted into the second connector 210 in the reverse direction, that is, the inspection chip 100 is inserted into the inspection board 200 in the reverse direction.
  • the positions of the custom CC1 detection pins and CC2 detection pins are different from those of the standard protocol, which can prevent users from mistakenly plugging in the USB Type-C of the standard communication protocol, allowing the standard protocol and custom The interface will not conflict.
  • OUT1-5 on the USB Type-C male connector and OUT1-5 on the USB Type-C female connector have a one-to-one correspondence, that is, OUT1 corresponds to OUT1 ;
  • the corresponding relationship is reversed, that is, OUT1 corresponds to OUT5.
  • each current channel in the USB Type-C female connector can be connected to an independent first diode (that is, D1-D5), and then share a second diode.
  • the pole tube (ie D6) is connected to the ground, which can provide an overvoltage protection value of 1.6V.
  • the protection voltage value here is: normal signal voltage ⁇ protection voltage value ⁇ maximum withstand voltage of MCU input port.
  • other diodes can be connected in series after the second diode.
  • the forward voltage drop of an ordinary switching diode (such as 1N4148) is 0.8V.
  • the first connector 110 is a male lightning connector.
  • the second connector 210 is a female lightning connector.
  • the function of the above-mentioned USB Type-C terminal can also be realized through the cooperation of the male lightning connector and the female lightning connector (ie, the Lightning terminal).
  • the specific structures of the first connector 110 and the second connector 210 can be selected according to actual needs.
  • the first connector 110 and the second connector 210 communicate according to a second preset communication protocol.
  • the second preset communication protocol may be a standard protocol of lightning connector terminals (ie, Lightning terminals).
  • the second preset communication protocol may also be a customized communication protocol of the lightning connector terminal, as long as the communication between the first connector 110 and the second connector 210 can be realized. And it is sufficient to ensure that the lightning connector terminal adopting the standard protocol will not damage the detection board 200 when inserted into the second connector 210.
  • the detection board 200 further includes a micro battery 400 and a voltage stabilization protection circuit 500.
  • the micro battery 400 is electrically connected to the second connector 210 through the voltage stabilization protection circuit 500.
  • the micro battery 400 may be a button battery.
  • the micro battery 400 may also be a micro lithium battery or a micro alkaline battery or the like. The specific type of the micro battery 400 can be selected according to actual needs.
  • the specific structure of the voltage stabilization protection circuit 500 is not specifically limited, as long as it is ensured that the detection board 200 can be protected from damage when the input voltage at the second connector 210 is too large.
  • the voltage stabilization protection circuit 500 may be composed of a first voltage regulator, a resistor, and a switch tube with a unidirectional conduction function.
  • the voltage stabilization protection circuit 500 can also be constructed by a traditional voltage stabilization circuit and a switch tube with a unidirectional conduction function. The use of the voltage stabilization protection circuit 500 can protect the detection board 200 from damage when the input voltage at the second connector 210 is too large, and increase the service life of the detection board 200.
  • the voltage stabilization protection circuit 500 includes a voltage regulator 510 and a current limiting component 520.
  • the input terminal of the voltage regulator 510 is electrically connected to the micro battery 400.
  • the first output terminal of the voltage regulator 510 is grounded.
  • the input terminal of the current limiting component 520 is electrically connected to the second output terminal of the voltage regulator 510.
  • the output end of the current limiting component 520 is electrically connected to the second connector 210.
  • the specific structure of the current limiting component 520 is not specifically limited, as long as it has current limiting and unidirectional conduction functions.
  • the specific structure of the current limiting component 520 can be selected according to actual needs.
  • the current limiting component 520 may be composed of a sliding rheostat and a switch tube with a unidirectional conduction function.
  • the current-limiting component 520 may be composed of a fixed resistance resistor and a switch tube with a unidirectional conduction function.
  • the current limiting component 520 includes a current limiting resistor 521 and a diode 522.
  • One end of the current limiting resistor 521 is electrically connected to the second output end of the voltage stabilizer 510.
  • the anode of the diode 522 is electrically connected to the other end of the current limiting resistor 521.
  • the cathode of the diode 522 is electrically connected to the second connector 210.
  • the micro battery 400 is powered by a 3V or 3.7V micro battery.
  • the voltage of the micro battery 400 will drop continuously during the discharge process.
  • a 1.5V low dropout voltage regulator chip ie, the voltage regulator 510 is used.
  • the voltage stabilizing chip can output a stable 1.5V voltage. After passing through the current-limiting resistor 521 and the diode 522, power is supplied to the detection chip 100 through the second connector 210.
  • the purpose of using the diode 522 is to use the unidirectional conductivity of the diode 522 to prevent the 5V voltage from being poured in and protect the detection board when the user mistakenly connects the USB Type-C terminal using the standard protocol. 200.
  • the current limiting resistor 521 is used to limit the working current of the detection chip 100. Because the maximum current of each detection channel of the detection chip 100 can reach 1mA, the continuous working current that the micro battery 400 can support is 100uA, and the maximum range of the current channel of the MCU (ie the microcontroller 220) is 250uA Therefore, it is necessary to limit the current of the detection wafer 100 to be less than 250uA to ensure the safety of use.
  • the micro battery 400 only supplies power to the detection chip 100, and does not supply power to the MCU (ie, the microcontroller 220), so the power consumption is extremely low when the detection chip 100 is not connected. In this way, the service life of the micro battery 400 can be increased.
  • An embodiment of the present application provides a saliva detection system, including a saliva detection device 10 and a host device 300.
  • the saliva detection device 10 includes a detection chip 100, a first connector 110 and a detection board 200.
  • the detection chip 100 is used to detect saliva to obtain saliva detection data.
  • the first connector 110 is fixedly connected to the detection chip 100.
  • the detection board 200 includes a second connector 210 and a microcontroller 220 that are plug-in connection with the first connector 110.
  • the microcontroller 220 is electrically connected to the second connector 210.
  • the microcontroller 220 is used to obtain the saliva detection data of the detection chip 100 and perform data interaction with the host device 300.
  • the application process is as follows:
  • the test chip 100 is inserted into the second connector 210 in the test board 200 through the first connector 110, and the host device 300 (such as a mobile phone, NFC card reader, etc.) is used to paste Reading is performed on the NFC coil 231 (ie, the wireless communication device 230) of the detection board 200.
  • the MCU ie, the microcontroller 220 is activated and starts to work.
  • the MCU After the MCU detects the current of each channel, it converts the concentration of the corresponding substance into the concentration of the corresponding substance, and then sends the concentration data to the host device 300 through the NFC coil 231. Finally, the host device 300 displays results, such as mobile phone APP data display, waveform display, etc., and stores the background database for long-term monitoring.
  • the present application adopts a separate design for the detection wafer 100 and the detection board 200, and through the cooperation of the first connector 110 and the second connector 210, the saliva can be Substance detection is not only easy to operate, but also can be used in any place, with the advantage of strong adaptability. At the same time, the present application has the advantages of small size, simple structure, convenient carrying and low cost.

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Abstract

L'invention concerne un dispositif et un système de test de salive comprenant une puce de test (100), un premier connecteur (110) et une plaque de test (200). La puce de test (100) est utilisée pour tester la salive de façon à acquérir des données de test de salive. Le premier connecteur (110) et la puce de test (100) sont connectés de manière fixe. La plaque de test (200) comprend un second connecteur (210) connecté par insertion au premier connecteur (110), ainsi qu'un microcontrôleur (220). Le microcontrôleur (220) et le second connecteur (210) sont connectés électriquement. Le microcontrôleur (220) est utilisé pour acquérir les données de test de salive en provenance de la puce de test (100). L'invention concerne également un système de test de salive. La puce de test (100) et la plaque de test (200) sont conçues de manière à être détachées, ce qui facilite le fonctionnement et permet à la présente invention d'être utilisée à n'importe quel endroit et de présenter l'avantage d'une grande adaptabilité.
PCT/CN2019/077051 2019-01-18 2019-03-05 Dispositif et système de test de salive WO2020147173A1 (fr)

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CN201910048608.4 2019-01-18
CN201910048608.4A CN109856201A (zh) 2019-01-18 2019-01-18 唾液检测装置

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