WO2020111731A1 - Dispositif d'imagerie photoacoustique 3d - Google Patents

Dispositif d'imagerie photoacoustique 3d Download PDF

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Publication number
WO2020111731A1
WO2020111731A1 PCT/KR2019/016370 KR2019016370W WO2020111731A1 WO 2020111731 A1 WO2020111731 A1 WO 2020111731A1 KR 2019016370 W KR2019016370 W KR 2019016370W WO 2020111731 A1 WO2020111731 A1 WO 2020111731A1
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WO
WIPO (PCT)
Prior art keywords
photoacoustic
unit
ultrasonic
collection unit
laser
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PCT/KR2019/016370
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English (en)
Korean (ko)
Inventor
송철규
이명영
Original Assignee
전북대학교산학협력단
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Publication of WO2020111731A1 publication Critical patent/WO2020111731A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image

Definitions

  • the present invention relates to a 3D photoacoustic imaging apparatus, and more particularly, to a 3D photoacoustic imaging apparatus for generating a 3D optoacoustic image by using sequentially collected optoacoustic signals by scanning an inspection area of an object. will be.
  • Photoacoustic imaging technology is a technique for imaging an object such as a biological tissue using a photoacoustic effect.
  • a non-ionizing laser pulse When radiated to an object, the emitted energy is converted into heat in the object, and among them, a wide band of ultrasonic waves is generated due to thermoelastic expansion.
  • photoacoustic imaging technology is to collect ultrasonic waves generated from an object by a laser pulse using an ultrasonic transducer and to construct an image using the collected ultrasonic information.
  • Patent Document 1 (Republic of Korea Patent Publication No. 10-2017-0093378, published on August 16, 2017) discloses a thrombus detection system based on photoacoustic imaging.
  • the photoacoustic imaging technology disclosed in Patent Document 1 is limited to the position of the ultrasonic sensor in which the inspection area of the object detects photoacoustic.
  • a two-dimensional image generated from photoacoustic information collected by an ultrasonic sensor has a problem that it is difficult to accurately determine a disease such as a blood clot of an object.
  • the present invention is to provide a 3D photoacoustic imaging apparatus capable of generating a 3D photoacoustic image by scanning an ultrasonic collector.
  • the present invention is to provide a 3D photoacoustic imaging apparatus capable of variously adjusting the resolution of a 3D photoacoustic image.
  • a 3D photoacoustic imaging apparatus includes a laser irradiation unit that irradiates a laser pulse to an object; An ultrasonic collection unit for collecting the photoacoustic signal generated by the thermal elastic expansion of the object by the laser pulse; A scanning unit that moves the ultrasound collection unit to scan an inspection area of the object; And an optoacoustic generator for generating a three-dimensional optoacoustic image using the optoacoustic signal collected from the ultrasonic collector.
  • the photoacoustic generation unit generates two-dimensional photoacoustic images using the photoacoustic signals collected while moving the ultrasonic collection unit, and combines the two-dimensional photoacoustic images based on scan positions of the ultrasonic collection unit to generate the three-dimensional image. Create photoacoustic images.
  • the 3D photoacoustic imaging apparatus may further include a control unit that collects the photoacoustic signals from the ultrasonic collection unit and controls the scan unit.
  • the controller may control the scan unit to move the ultrasonic collection unit to collect the photoacoustic signal at the second location.
  • the ultrasonic collection unit includes a probe unit that collects the photoacoustic signal, and the probe unit is two-dimensionally arranged on a hemispherical surface of a probe support portion formed in a hemispherical shape recessed toward the opposite side of the object. It may include a plurality of ultrasonic probes.
  • the laser irradiation unit includes a laser generating unit that generates the laser pulse, and a laser output unit that outputs the laser pulse to the object, and the laser output unit may be provided at the center of the probe unit.
  • the scan unit may be configured to rotate the probe unit around the object.
  • the scanning unit may include: a first stage that moves the ultrasound collection unit in the vertical direction to scan the inspection area of the object in the vertical direction; And a second stage that rotates the ultrasound collection unit around the object and scans the inspection area of the object in a circumferential direction.
  • the second stage may include a circular rotating plate rotatably installed around an axis in the vertical direction; A driving unit for rotationally driving the rotating plate; A support installed downwardly on one side of the periphery of the rotating plate; And an equilibrium holder which is installed downward on a periphery of the rotating plate opposite to the support.
  • the ultrasonic collection unit may be coupled to the support in the direction toward the object.
  • the second stage may include a step motor that stops after moving the ultrasonic collection unit at a predetermined interval along the circumferential direction.
  • the laser irradiation unit may irradiate the laser pulse to the object whenever the second stage is stopped after moving at the preset interval, and the ultrasound collection unit may collect the photoacoustic signal at each preset interval.
  • the laser irradiation unit may output a trigger signal synchronized with the laser pulse, and the photoacoustic generator may synchronize the trigger signal to collect the photoacoustic signal from the ultrasonic collection unit to generate the two-dimensional photoacoustic image. .
  • the laser irradiation unit may include a tunable laser that can change the wavelength of the laser pulse.
  • the laser irradiation unit may vary the wavelength of the laser pulse in a wavelength range that induces thermal expansion elasticity on the object to generate an ultrasonic signal from target materials of the object.
  • the control unit may control the wavelength and repetition rate of the tunable laser.
  • the 3D photoacoustic imaging apparatus may further include a display unit displaying a 3D photoacoustic image generated by the photoacoustic generating unit.
  • a 3D photoacoustic imaging apparatus capable of generating a 3D photoacoustic image by scanning an ultrasonic collector is provided.
  • a 3D photoacoustic imaging apparatus capable of variously adjusting the resolution of a 3D photoacoustic image is provided.
  • FIG. 1 is a side view schematically showing a 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • FIG. 2 is a bottom view of a 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • FIG 3 is a front view of an ultrasound collection unit constituting a 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • FIG. 4 is a block diagram of a 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • 5 and 6 are views for explaining the operation of the 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • FIG. 7 is an operation flowchart of a 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • the 3D photoacoustic imaging apparatus 100 includes a laser irradiation unit 110, an ultrasonic collection unit 120, a scanning unit 130, and an optoacoustic generation unit ( 140).
  • the 3D photoacoustic imaging apparatus 100 irradiates a laser pulse that causes thermoelastic expansion to an object 10 such as a biological tissue by a photoacoustic effect, and the object ( The photoacoustic signal generated from the object is collected by the thermoelastic expansion of 10) to generate a 3D photoacoustic image by photoacoustic tomography.
  • the laser irradiation unit 110 irradiates a laser pulse to the object 10.
  • the laser pulse emitted to an object such as body tissue may be a non-ionizing laser pulse.
  • the laser pulse may have a wavelength that induces thermal expansion elasticity on the object 10 to generate an ultrasonic signal from the target material of the object 10.
  • the target material may include, but is not limited to, a carotid artery thrombus.
  • the laser irradiator 110 laser outputs a laser pulse generated by the laser generator 112, such as a pulse laser device that generates a non-ionizing laser pulse, and a laser pulse generated by the laser generator 120. It may include a laser transmission unit (optical fiber) 114 for transmitting to the unit 116, and a laser output unit 116 for outputting a laser pulse transmitted through the laser transmission unit 114 to the object.
  • a laser transmission unit optical fiber
  • the laser generator 112 may be provided as a tunable laser.
  • the laser generator 112 may generate laser pulses of various wavelengths and irradiate the object.
  • the pulse period of the laser pulse generated by the laser generator 112 may be preset or controlled according to the position of the ultrasonic collection unit 120 moved by the scan unit 130.
  • the wavelength of the laser pulse may be set to include 1210 nm, but is not limited thereto.
  • the ultrasonic collection unit 120 collects the photoacoustic signal of the ultrasonic band emitted by the object 10 by reaction (thermoelastic expansion) by the laser pulse emitted by the laser irradiation unit 110.
  • the ultrasonic collection unit 120 may include a probe unit for collecting photoacoustic signals in the ultrasonic band.
  • the ultrasound collection unit 120 may be provided as an array ultrasound probe unit in which a plurality of ultrasound probes are arranged in a peripheral area of the laser output unit 116.
  • the laser output unit 116 may be disposed at the center of the probe unit.
  • the ultrasound collection unit 120 may include a probe support unit 122 and a plurality of ultrasound probes 120a.
  • the ultrasound collection unit 120 may be provided as a multi-channel ultrasound probe 120a such as 128 channels.
  • the probe support 122 may be installed on the lower surface of the rotating plate 136 of the scan unit 130 and fixed to the lower end of the support 138a extending downward.
  • the ultrasound collection unit 120 may be coupled to the support 138a in a direction toward the object 10.
  • the probe support 122 may be formed with a hemispherical surface 124 in which the front portion toward the object 10 is recessed toward the opposite side of the object 10.
  • the probe support 124 may have a plurality of ultrasonic probes 120a arranged two-dimensionally on the hemispherical surface 124 of the probe support 122.
  • the plurality of ultrasonic probes 120a may be arranged in various forms such as a matrix structure and a concentric structure.
  • the scan unit 130 may scan the inspection area of the object 10 by moving the ultrasound collection unit 130.
  • the scan unit 130 may be configured to rotate the probe support unit 122 and the ultrasonic probes 120a of the ultrasonic collection unit 120 around the object 10.
  • the scan unit 130 may rotate the ultrasound collection unit 130 in an angle range corresponding to 360° or an inspection area of the object.
  • the scan unit 130 may include a first stage 132 and a second stage 134.
  • the first stage 132 may move the second stage 134 and the ultrasonic collection unit 120 installed therein in the vertical direction, and scan the inspection area of the object 10 in the vertical direction.
  • the first stage 132 may include a step motor that stops after moving the ultrasonic collection unit 120 at regular intervals along the vertical direction.
  • the second stage 134 may rotate the ultrasound collection unit 120 around the object 10 to scan the inspection area of the object 10 in the circumferential direction.
  • the second stage 134 includes a circular rotating plate 136 rotatably installed around the vertical axis 134a, a driving unit (not shown) for rotationally driving the rotating plate 136, and a rotating plate It may include a support 138a installed downward on one side of the periphery of 136 and a counterweight 138b installed downward on the periphery of the opposite side of the support 138a of the rotating plate 136.
  • the driving unit of the second stage 134 may include a step motor that stops after moving the ultrasonic collection unit 120 at a predetermined interval along the circumferential direction.
  • the balance holder 138b may be designed with a weight capable of maintaining the balance of the scan unit 130 in consideration of the load of the support 138a and the ultrasonic collection unit 120. Can be.
  • the photoacoustic generation unit 140 may generate a 3D photoacoustic image using the photoacoustic signal collected from the ultrasonic collection unit 120.
  • the photoacoustic generating unit 140 generates two-dimensional photoacoustic images by using the photoacoustic signals collected while moving the ultrasonic collection unit 120 by the scan unit 130, and the two-dimensional photoacoustic images are collected by the ultrasonic collector Based on the scan positions of 120, a 3D photoacoustic image may be generated.
  • the 3D photoacoustic imaging apparatus 100 may include a control unit 150.
  • the control unit 150 controls the laser generation unit 112 and the scan unit 130 of the laser irradiation unit 110 by collecting photoacoustic signals from the ultrasound collection unit 120.
  • the controller 150 moves the scan unit 130 to move the ultrasonic collection unit 120 to collect the photoacoustic signal at the second position.
  • the control unit 150 may control the wavelength and repetition rate (pulse period) of the tunable laser.
  • the laser irradiation unit 110 may irradiate the object 10 with a laser pulse whenever the second stage 134 is stopped after moving at a predetermined interval according to a control signal from the control unit 150.
  • the control unit 150 controls the scan unit 130 by determining the operation of the scan unit 130 by comparing the current position and the target position of the ultrasound collection unit 120.
  • the ultrasonic collection unit 120 may collect the photoacoustic signal for each set interval according to a control signal from the control unit 150.
  • 5 and 6 are views for explaining the operation of the 3D photoacoustic imaging apparatus according to an embodiment of the present invention.
  • 7 is an operation flowchart of a 3D photoacoustic imaging apparatus according to an embodiment of the present invention. 5 to 7, first, as shown in FIG. 5, when the laser pulse LS emitted by the laser output unit 116 is irradiated to the object (S10 ), by the laser pulse LS The photoacoustic signal PS of the ultrasound band generated from the object may be collected by the ultrasound collection unit 120 as shown in FIG. 6 (S20).
  • the ultrasound collection unit 120 may collect the photoacoustic signal every first interval in the vertical direction and the photoacoustic signal every second interval in the circumferential direction.
  • the ultrasound collection unit 120 transmits photoacoustic signals for each of the set positions at the first interval and the second interval while moving in the vertical direction and the circumferential (rotation) direction along the inspection area of the object 10 by the scan unit 130 Collect sequentially.
  • the photoacoustic signal PS generated from an object may be efficiently collected by the hemispherical surface 124 of the ultrasonic collector 120.
  • the photoacoustic signal PS collected by the ultrasonic collection unit 120 may be transmitted to the photoacoustic generation unit 140 through a light transmission unit (optical fiber).
  • the laser irradiation unit 110 may output a trigger signal synchronized with the laser pulse.
  • the trigger signal output from the laser irradiation unit 110 may be transmitted to the scan unit 130 and the photoacoustic generation unit 150 through the control unit 150.
  • the photoacoustic generation unit 150 collects the photoacoustic signal PS from the ultrasonic collection unit 120 in synchronization with the trigger signal, and then generates a two-dimensional photoacoustic image using the collected photoacoustic signal PS. Can be.
  • the control unit 150 scans the ultrasound collection unit 120 to move the ultrasound collection unit 120 to the second position in order to scan the inspection area of the object 10. 130 can be controlled (S30, S40).
  • the ultrasound collection unit 120 When the ultrasound collection unit 120 is moved to a predetermined scan position by the scan unit 130, the laser pulse is emitted by the laser irradiation unit 110 again, and the photoacoustic signal is collected by the ultrasound collection unit 120. .
  • the photoacoustic generator 140 scans the inspection area of the object 10 and generates a two-dimensional photoacoustic image each time it is moved to a scan position by using the photoacoustic signals sequentially collected by the ultrasonic collector 120. can do.
  • the optoacoustic generator 140 may combine the two-dimensional optoacoustic images based on scan positions (scan angles) to generate a three-dimensional optoacoustic image (S50 ). , S60).
  • the photoacoustic generating unit 140 rotates the directions of the 2D photoacoustic images according to the collection direction of the ultrasonic collection unit 120 that collects the photoacoustic signals to match the common coordinate system to rotate the 2D photoacoustic images.
  • a 3D photoacoustic image can be generated.
  • the 3D photoacoustic image generated by the photoacoustic generator 140 may be displayed through the display 160 (S70 ).
  • the 3D photoacoustic imaging apparatus can move (scan) the ultrasonic collection unit 120 in the vertical direction and the rotational direction, and can adjust the movement (scan) interval of the ultrasonic sensor unit 120.
  • a 3D photoacoustic image can be generated by photographing body tissue at a desired resolution.
  • the photoacoustic signals are collected while finely adjusting the movement (scan) interval of the ultrasonic collection unit 120 to generate a high resolution 3D photoacoustic image based on the collected photoacoustic signals.
  • the resolution of the photoacoustic image may be variously adjusted by adjusting a movement (scan) interval of the ultrasound collection unit 120 at a desired interval.
  • the accuracy of the photoacoustic signal is increased to improve the 3D photoacoustic image.
  • the accuracy can be improved and a clear 3D photoacoustic image can be obtained.
  • the 3D photoacoustic imaging apparatus can be utilized, for example, to grasp the internal structure of inflammatory blood vessels and to determine properties.
  • An embodiment according to the present invention relates to a three-dimensional photoacoustic imaging apparatus, and has the possibility of repeatability and industrial use in a diagnostic device using photoacoustics.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Acoustics & Sound (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

La présente invention concerne un dispositif d'imagerie photoacoustique 3D capable de générer une image photoacoustique 3D par balayage d'une unité de collecte ultrasonore, et capable d'ajuster de manière variée une résolution d'une image photoacoustique 3D. Le dispositif d'imagerie photoacoustique 3D, selon un mode de réalisation de la présente invention, comprend: une unité d'irradiation laser pour irradier une impulsion laser vers un objet; une unité de collecte ultrasonore pour collecter des signaux photoacoustiques générés par une expansion thermoélastique de l'objet au moyen de l'impulsion laser; une unité de balayage pour balayer une zone d'inspection de l'objet par déplacement de l'unité de collecte ultrasonore; et une unité de génération photoacoustique pour générer une image photoacoustique 3D à l'aide des signaux photoacoustiques collectés à partir de l'unité de collecte ultrasonore. L'unité de génération photoacoustique génère des images photoacoustiques 2D en utilisant les signaux photoacoustiques collectés tout en déplaçant l'unité de collecte ultrasonore, et combine les images photacoustiques 2D sur la base des positions de balayage de l'unité de collecte ultrasonore de façon à générer une image 3D.
PCT/KR2019/016370 2018-11-28 2019-11-26 Dispositif d'imagerie photoacoustique 3d WO2020111731A1 (fr)

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KR1020180149424A KR102180436B1 (ko) 2018-11-28 2018-11-28 3차원 광음향 영상 장치
KR10-2018-0149424 2018-11-28

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KR20230166390A (ko) 2022-05-30 2023-12-07 부산대학교 산학협력단 초음파 기반 호흡 보정을 이용한 3차원 광음향 영상 구현을 위한 장치 및 방법
KR20240069978A (ko) * 2022-11-14 2024-05-21 국립부경대학교 산학협력단 광음향 영상 및 초음파 영상 획득장치 및 그 방법

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KR101749602B1 (ko) * 2016-04-05 2017-06-21 포항공과대학교 산학협력단 비전도성 유체를 이용한 광해상도 광음향 현미경, 및 이를 이용한 광음향 영상 획득 시스템 및 방법
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