WO2020108459A1 - 一种磁共振引导的放射治疗系统成像质量控制体模 - Google Patents
一种磁共振引导的放射治疗系统成像质量控制体模 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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- the invention belongs to the field of magnetic resonance radiotherapy, and particularly relates to a magnetic resonance guided radiotherapy system imaging quality control phantom.
- Magnetic resonance has good soft tissue contrast, and no ionizing radiation damage caused by X-rays. It is very suitable for positioning imaging of patients who need radiation physiotherapy. With the improvement of multi-modal system integration technology, the integration of magnets, electron beam equipment, and cobalt 60 equipment has gradually been realized. More and more integrated magnetic resonance radiotherapy simulation positioning systems are released and put into clinical application, such as: ViewRay equipment (0.35T magnetic field + cobalt 60 system), MRI-Linac equipment (1.5T magnetic field 6MV Linac system) and independent positioning Use a large aperture flat bed magnetic resonance system, etc.
- the magnetic resonance radiotherapy simulation positioning system dedicated to radiotherapy has the applicability and compatibility of radiotherapy. It has unique design in hardware configuration such as examination table, magnet aperture, magnet length, etc., as well as scan sequence, positioning software and other software configurations, and some related special imaging parameters appear accordingly. And the imaging of the magnetic resonance simulation positioning system will be directly applied to the formulation of radiotherapy planning, and its imaging effect has a direct relationship with the radiation dose.
- the quality control and treatment assurance testing of the dedicated magnetic resonance radiotherapy simulation positioning system are of great significance for radiation positioning and dose assurance.
- these testing phantoms are not suitable for the quality testing of the special magnetic resonance radiotherapy simulation positioning system.
- the dedicated magnetic resonance radiotherapy simulation positioning system has an imaging area with a large aperture (greater than 60 cm).
- a common quality control phantom with a diameter of about 20 cm it cannot meet the needs of imaging detection in a wide range.
- the examination bed of the special magnetic resonance radiotherapy simulation positioning system is a flat type, and a special support frame is placed to place various scanning coils, which requires that the test phantom can be targeted for different coil types for targeted testing.
- the most important thing is that some special radiotherapy simulation positioning magnetic resonance systems require magnets to have openings to facilitate the passage of the electron beam of the linear accelerator. This special design cannot be tested with a small-sized detection phantom.
- the object of the present invention is to provide an imaging quality control phantom for a magnetic resonance guided radiotherapy system.
- the phantom can meet the needs of large-scale imaging detection of a dedicated magnetic resonance radiotherapy simulation positioning system.
- the technical solutions of the present invention are:
- a magnetic resonance guided radiotherapy system imaging quality control phantom including four parts, namely a first part, a second part, a third part and a fourth part, all of which are cylindrical structures, the first part and the third Part constitutes the first cylindrical structure, the second part and the fourth part constitute the second cylindrical structure, the first cylindrical structure and the second cylindrical structure have the same diameter, and the length ratio is 1:2.5-3.5; the first cylinder The diameter of the shaped structure and the second cylindrical structure is 35-45cm;
- the combined surface of the first part and the third part is parallel to the axis of the first cylindrical structure, and the first part is larger than the third part; the combined surface of the second part and the fourth part is parallel to the axis of the first cylindrical structure, the second part Greater than the fourth part;
- the combined surface of the first and third parts coincides with the combined surface of the second and fourth parts;
- the inner part of the first part is hollow, and the inside includes a plurality of wedge-shaped blocks, the plurality of wedge-shaped blocks are identical, the wedge-shaped blocks are arranged in a ring along the axis of the first cylindrical structure, and the tip of the wedge-shaped block faces the axis;
- the third part is the solid structure, which is provided with a number of cylindrical grooves with different diameters, the axis of the cylindrical groove is parallel to the axis of the first cylindrical structure;
- Both the second part and the fourth part are provided with a plurality of hollow square cylinders, the square cylinders are arranged parallel to the axis of the second cylindrical structure, and several square cylinders are arranged in a grid-like structure;
- the outer walls and internal structures of the first part, second part, third part, and fourth part are made of materials that do not generate magnetic resonance signals, and these four parts are provided with water injection ports to inject the test liquid.
- the diameter of the first cylindrical structure and the second cylindrical structure is 35-45 cm, which can meet the needs of imaging detection in a wide range of the dedicated magnetic resonance radiotherapy simulation positioning system.
- the inner part of the first part is hollow, and the wedge-shaped blocks are arranged in a ring along the axis of the first cylindrical structure.
- the wedge-shaped structure is a solid material, which is imaged in a magnetic resonance image and used to test the limit resolution of the magnetic resonance system.
- the test solution fills the inside of the first part.
- the third part is the solid structure.
- the hole-shaped grooves are hollow and filled with test liquid, which is used to test the spatial resolution of the magnetic resonance system.
- the hollow square cylinders in the second and fourth parts are used as the basic geometric distortion test unit to test the geometric distortion of the magnetic resonance system in the magnetic resonance image.
- the length of the first cylindrical structure is 8-12 cm, and the length of the second cylindrical structure is 35-45 cm.
- the length is suitable for the magnetic field center length of magnetic resonance imaging.
- the width ratio of the first part and the third part is 3:1.
- the width ratio of the second part and the fourth part is 3:1.
- the angle of the wedge-shaped structure is 2°, and the angle of the ring-shaped structure enclosed by the wedge-shaped structure is 180°.
- the angle of the ring structure enclosed by the wedge block is limited to 180°, which is used to test the limit resolution.
- the materials of the outer wall and internal structure of the first part, the second part, the third part, and the fourth part are organic glass or 3D printing materials.
- the side length of the square cylinder is 0.8-1.2 cm, and the wall thickness is 0.08-0.12 cm.
- the number of the square pillars is 90-120.
- the top plate, the bottom plate and the left and right side plates of the phantom are all provided with cross-shaped line marks. Used for laser positioning.
- the cross-shaped line mark is etched or printed on the surface of the phantom.
- a hollow centerline column is provided at the central axis of the second cylindrical structure, and the material of the centerline column is the same as the material of the square column.
- a bubble level is provided outside the phantom. To adjust the level of the phantom.
- the large-aperture test phantom contains a 3 cm layer of pure water or an overflow layer. Used to test the signal-to-noise ratio and uniformity of magnetic resonance.
- the test liquid is double distilled water, nickel chloride, sodium chloride or copper sulfate pentahydrate. It can also be replaced with other magnetic resonance standard test fluids.
- the diameter of the first cylindrical structure and the second cylindrical structure is 35-45 cm, which can meet the needs of imaging detection in a wide range of the dedicated magnetic resonance radiotherapy simulation positioning system.
- the diameter of the first cylindrical structure and the second cylindrical structure is 35-45 cm, which can meet the needs of imaging detection in a wide range of the dedicated magnetic resonance radiotherapy simulation positioning system.
- the inner part of the first part is hollow, and the wedge-shaped blocks are arranged in a ring along the axis of the first cylindrical structure.
- the wedge-shaped structure is a solid material, which is imaged in a magnetic resonance image and used to test the limit resolution of the magnetic resonance system.
- the test solution fills the inside of the first part.
- the third part is the solid structure.
- the hole-shaped grooves are hollow and filled with test liquid, which is used to test the spatial resolution of the magnetic resonance system.
- the hollow square cylinders in the second and fourth parts are used as the basic geometric distortion test unit to test the geometric distortion of the magnetic resonance system in the magnetic resonance image.
- FIG. 1 is a schematic structural view of a phantom of the present invention
- FIG. 2 is a schematic structural view of another perspective view of the phantom of the present invention.
- FIG. 3 is a schematic view of the front view of the phantom of the present invention.
- FIG. 4 is a schematic view of the rear view structure of the phantom of the present invention.
- FIG. 5 is a schematic view of the side view structure of the phantom of the present invention.
- FIG. 6 is a schematic diagram of three-dimensional geometric distortion measurement of the large-aperture test phantom of the present invention.
- FIG. 7 is a three-dimensional geometric distortion measurement display diagram of the large-aperture test phantom of the present invention.
- a magnetic resonance guided radiotherapy system imaging quality control phantom includes four parts, namely a first part 1, a second part 2, a third part 3, and a fourth part 4, which The four parts are all cylindrical structures, the first part 1 and the third part 3 form a first cylindrical structure, the second part 2 and the fourth part 4 form a second cylindrical structure, the first cylindrical structure and the second cylindrical structure Equal diameter, and its length ratio is 1:2.5-3.5; the diameter of the first cylindrical structure and the second cylindrical structure is 35-45cm, the length of the first cylindrical structure is 8-12cm, the length of the second cylindrical structure The length is 35-45cm to suit the magnetic field center length of magnetic resonance imaging.
- the combined surface of the first part 1 and the third part 3 is parallel to the axis of the first cylindrical structure, and the first part 1 is larger than the third part 3, in a direction perpendicular to the combined surface of the first part 1 and the third part 3, the first part
- the width ratio of 1 and the third part 3 is 3:1.
- the combined surface of the second part 2 and the fourth part 4 is parallel to the axis of the first cylindrical structure, the second part 2 is larger than the fourth part 4; in a direction perpendicular to the combined surface of the second part 2 and the fourth part 4,
- the width ratio of the second part 2 and the fourth part 4 is 3:1.
- the combined surface of the first part 1 and the third part 3 coincides with the combined surface of the second part 2 and the fourth part 4;
- the interior of the first part 1 is hollow, which includes several wedge-shaped blocks 8 .
- the wedge-shaped blocks 8 are arranged circularly along the axis of the first cylindrical structure, and the tip of the wedge-shaped block 8 faces the axis;
- the angle of the wedge-shaped block 8 is 2°, and the wedge-shaped block 8
- the angle is 180°.
- the angle of the ring structure enclosed by the wedge-shaped block 8 is limited to 180°, which is used to test the limit resolution.
- the third part 3 is a solid structure, and a number of cylindrical grooves 7 with different diameters are provided inside, and the axis of the cylindrical groove 7 is parallel to the axis of the first cylindrical structure;
- each of the second part 2 and the fourth part 4 is provided with a plurality of hollow square cylinders 6, the square cylinders 6 are arranged parallel to the axis of the second cylindrical structure, and several square cylinders are arranged A grid-like structure; the side length of the square cylinder 6 is 0.8-1.2cm, and the wall thickness is 0.08-0.12cm.
- the number of square cylinders 6 is 90-120.
- the outer walls and internal structures of the first part 1, the second part 2, the third part 3, and the fourth part 4 are made of materials that do not generate magnetic resonance signals, and these four parts are provided with water injection ports to inject the test liquid.
- the diameter of the first cylindrical structure and the second cylindrical structure is 35-45 cm, which can meet the needs of imaging detection in a wide range of the dedicated magnetic resonance radiotherapy simulation positioning system.
- the inner part of the first part is hollow, and the wedge-shaped blocks 8 are arranged in a ring along the axis of the first cylindrical structure.
- the wedge-shaped structure is a solid material, which is imaged in a magnetic resonance image and used to test the limit resolution of the magnetic resonance system.
- the test solution fills the inside of the first part.
- the third part is the solid structure.
- the hole-shaped grooves are hollow and filled with test liquid, which is used to test the spatial resolution of the magnetic resonance system.
- the hollow square cylinders in the second and fourth parts are used as the basic geometric distortion test unit to test the geometric distortion of the magnetic resonance system in the magnetic resonance image.
- the materials of the outer wall and internal structure of the first part 1, the second part 2, the third part 3, and the fourth part 4 are organic glass or 3D printing materials.
- the top plate, the bottom plate and the left and right side plates of the phantom are all provided with cross-shaped line marks for laser positioning, and the cross-shaped line marks are etched or printed on the surface of the phantom.
- a hollow centerline column is provided at the center axis of the second cylindrical structure, and the material of the centerline column is the same as the material of the square column 6.
- a bubble level is provided outside the phantom to adjust the level of the phantom.
- the large-aperture test phantom contains a 3cm layer of pure water or overflow. Used to test the signal-to-noise ratio and uniformity of magnetic resonance.
- the test liquid can be double distilled water, nickel chloride, sodium chloride or copper sulfate pentahydrate.
- the upper half of the large-aperture test phantom can be used alone for a magnetic resonance guided radiotherapy system with a flat bed positioning bed.
- the combination of the upper and lower parts can be used for the magnetic resonance system with an arc-shaped examination table.
- the large-aperture test phantom is mainly filled with a magnetic resonance test solution.
- the test fluid can be replaced through the bolt ports at both ends of the phantom.
- a matrix grid image can be formed at specific positions on the cross section, sagittal plane and coronal plane (the grid forms a dark grid with no signal, and the bright signal of the surrounding test fluid), and a point cloud image (The grid forms dark spots with no signal, and bright signals around the test fluid).
- the above-mentioned grid column structure is connected in the form of a tenon and mortise at the intersection of the grid. If a 3D printed grid is used, it can be printed in one piece without connecting.
- the above grid structure has a thickened centerline columnar structure mark at the centerline position of the phantom cylinder, and when it is traversed, a thickened columnar grid or dot image will be formed on the scanned image. Used to identify the physical center of the phantom.
- the large-aperture test phantom contains a 3cm pure water layer or an overflow layer for testing the signal-to-noise ratio and uniformity of magnetic resonance.
- the large-aperture test phantom contains a triangular plexiglass or 3D printed material structure with a 45-degree diagonal slope.
- the structure has three groups and is placed orthogonally. It is used to test the spatial positioning accuracy on the cross-section, sagittal plane, and coronal plane.
- the large-aperture test phantom contains a 30-degree long slope of plexiglass or 3D printed material structure for testing the thickness and layer deviation of the magnetic resonance scan.
- the large-aperture test phantom contains a star-shaped test structure, specifically a 2 degree wedge-shaped plexiglass or 3D printed material structure, placed in a circle, used to measure the modulation transfer function MTF and the limit resolution.
- the large-aperture test phantom is equipped with a 3D digital lattice model, which is stored in the form of online software and random software. After opening through DICOM browser or image reading software, any level and any FOV can be selected.
- the large-aperture test phantom image obtained by the user can be registered and fused by reading the field of view and matrix information in the DICOM file header and the corresponding FOV model of the digital lattice model with the actual image of the phantom.
- Through two-color display or 3D space display visually display the geometric distortion caused by field deviation.
- the large-aperture test phantom is equipped with 3D digital processing software, which can retrieve the DICOM sequence image of the phantom on the computer, and automatically recognize the phantom positioning block and the layer thickness and matrix in the DICOM image Information, automatically determine the quality control test layer image in the sequence image. Automatically identify the aforementioned grid or point cloud signals in the image of the quality control test layer, use projection to determine the center of mass or geometric center of the top angle or point of the grid, and determine the phantom/image center, FOV and distance from the center 22.5cm/ Image range of 17.5cm/10cm.
- Digital processing software automatically calculates the difference between the point image and the real position at different distances from the phantom/image center, and uses different signals or colors to indicate the difference in three different directions.
- the change in the field strength or geometric distortion of the FOV measured by the phantom is represented in a graph.
- the 3D digital lattice model can calculate the brightness amplitude of the phantom water signal.
- the corresponding FOV model of the digital lattice model is registered and fused with the actual image of the phantom, and the signal difference of each spatial position in the image is displayed in pseudo color contrast. Used to compare the signal amplitude and signal-to-noise ratio of multi-channel coils with spatial position.
- the large-aperture test phantom test solution and various internal structures can be scanned and imaged under CT at the same time, and can also be applied to the quality control and quality assurance of CT-guided radiotherapy systems.
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Abstract
Description
Claims (10)
- 一种磁共振引导的放射治疗系统成像质量控制体模,其特征在于:包括四部分,分别为第一部分、第二部分、第三部分和第四部分,这四部分均为筒状结构,第一部分和第三部分组成第一圆柱状结构,第二部分和第四部分组成第二圆柱状结构,第一圆柱状结构和第二圆柱状结构等径,且其长度比为1:2.5-3.5;第一圆柱状结构和第二圆柱状结构的直径为35-45cm;第一部分和第三部分的组合面与第一圆柱状结构的轴线平行,且第一部分大于第三部分;第二部分和第四部分的组合面与第一圆柱状结构的轴线平行,第二部分大于第四部分;第一部分和第三部分的组合面与第二部分和第四部分的组合面重合;第一部分的内部中空,其内部包括若干个楔形块,若干个楔形块完全相同,楔形块沿第一圆柱状结构的轴线环形排列,且楔形块的尖端朝向轴线;第三部分为实体结构,内部设置有若干个直径不等的柱形槽,柱形槽的轴线与第一圆柱状结构的轴线平行;第二部分和第四部分内部均设置有若干个中空的方形柱体,方形柱体与第二圆柱状结构的轴线平行设置,且若干个方形柱体排列成网格状结构;第一部分、第二部分、第三部分和第四部分的外壁及内部结构均由不会产生磁共振信号的材质制成,且这四部分均设置注水口,以注入测试液。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:第一圆柱状结构的长度为8-12cm,第二圆柱状结构35-45cm。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:沿垂直于第一部分和第三部分的组合面的方向,第一部分和第三部分的宽度比为3:1。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:沿垂直于第二部分和第四部分的组合面的方向,第二部分和第四部分的宽度比为3:1。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:所述楔形结构的角度为2°,楔形结构围成的环形结构的角度为180°。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:第一部分、第二部分、第三部分和第四部分的外壁及内部结构的材质为有机玻璃或3D打印材料。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:所述方形柱体的边长为0.8-1.2cm,壁厚为0.08-0.12cm,方形柱体的数量为90-120个。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:所述体模的顶板、底板和左右侧板上均设置有十字形线条标识,十字形线条标识通过蚀刻 或印刷于体模表面。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:所述与第二圆柱状结构的中心轴线位置设置有中空的中心线柱,中心线柱的材质与方形柱体的材质相同。
- 根据权利要求1所述的磁共振引导的放射治疗系统成像质量控制体模,其特征在于:所述体模的外部设置有气泡式水准仪。
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