WO2020107210A1 - Composition de plantes médicinales chinoises pour le traitement de l'asthme, sa méthode de préparation et son utilisation pharmaceutique - Google Patents

Composition de plantes médicinales chinoises pour le traitement de l'asthme, sa méthode de préparation et son utilisation pharmaceutique Download PDF

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Publication number
WO2020107210A1
WO2020107210A1 PCT/CN2018/117660 CN2018117660W WO2020107210A1 WO 2020107210 A1 WO2020107210 A1 WO 2020107210A1 CN 2018117660 W CN2018117660 W CN 2018117660W WO 2020107210 A1 WO2020107210 A1 WO 2020107210A1
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Prior art keywords
parts
servings
chinese medicine
traditional chinese
medicine composition
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PCT/CN2018/117660
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English (en)
Chinese (zh)
Inventor
刘志杰
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深圳市得道健康管理有限公司
刘志杰
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Priority to CN201880028354.3A priority Critical patent/CN111491649A/zh
Priority to PCT/CN2018/117660 priority patent/WO2020107210A1/fr
Publication of WO2020107210A1 publication Critical patent/WO2020107210A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Definitions

  • the invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, its preparation method and application.
  • the symptoms are fever or slight fever, coughing, or chills, coldness, warmth, or sweating, nausea and nausea, Runny nose, uncomfortable heart, heavy pain around the body, shoulder and back joint pain, etc.; and asthma caused by exogenous cold, or rhinitis, headache, pharyngitis, rheumatic joint pain, puffiness, etc. caused by cold cold water drinking Symptoms, there is no significant effect of the Chinese medicine composition.
  • the technical problem to be solved by the present invention is: how to provide a traditional Chinese medicine composition for treating various diseases described in the background art, and its preparation process and application.
  • the present invention provides a traditional Chinese medicine composition prepared by the following proportions of traditional Chinese medicine raw materials in parts by weight: ephedra 5-60 parts, Guizhi 15-75 parts, asarum 3 -45 servings, pinellia 15-75 servings, schisandra 10-50 servings, almonds 9-45 servings, roasted licorice 10-60 servings.
  • the further technical solution is as follows: based on parts by weight, prepared from the following combination of traditional Chinese medicine raw materials: ephedra 45 parts, guizhi 45 parts, asarum 45 parts, pinellia 65 parts, schisandra 40 parts, almond 30 parts, licorice 45 Copies.
  • the present invention also provides a method for preparing a traditional Chinese medicine composition for treating wind and cold as described in the first aspect, including the following steps:
  • the further technical solution is: before the first decoction of ephedra and pinellia, the method further includes soaking ephedra and pinellia with water, wherein the ratio of the mass of the traditional Chinese medicine composition to the added water is 1:6- 7.
  • the soaking time is 40-90min.
  • a further technical solution is: when boiling for the first time, first heat to boiling, then cook at 100-115°C for 20-40min.
  • a further technical solution is that: during the second decoction, decoction is performed at 100-115°C for 60-90 min.
  • the final amount of medicinal juice obtained is 1/5-3/10 of the volume of water added.
  • the present invention provides the use of the traditional Chinese medicine composition as described in the first aspect in the preparation of a medicament for treating wind-cold, relieving muscle attack, removing stagnation and dissipating qi, and diminishing asthma.
  • the traditional Chinese medicine composition disclosed by the invention has the effects of treating wind-cold, relieving muscles and attacking the table, removing stagnation and dispelling drink, and reducing asthma.
  • the above-mentioned components cooperate with each other according to the compatibility relationship of "Jun, Chen, Zuo and Shi", and work synergistically against rhinitis, headache, headache caused by fever, chills, asthma caused by external cold, internal injury and cold stagnation, or virtual cold water.
  • Pharyngitis, rheumatic arthralgia, edema and other symptoms have obvious healing effect or relief effect. Suitable for clinical application.
  • FIG. 1 is a flowchart of a method for preparing a traditional Chinese medicine composition provided by an embodiment of the present invention.
  • the embodiment of the present invention provides a traditional Chinese medicine composition, and ephedra, twig, asarum, pinellia, schisandra, almond, and licorice root are selected as raw materials of traditional Chinese medicine.
  • ephedra has the effects of relieving sweating, relieving lungs and diarrhea, and diminishing swelling. It can treat empirical manifestations of wind and cold, chest tightness, cough, edema of feng shui, rheumatism, yin and sputum.
  • Guizhi has the effects of relieving sweating, relieving cold, relieving pain and tonifying the qi.
  • Asarum has the functions of relieving cold and dispelling cold, dispelling wind and analgesic, Tongqiao, warming lung and drinking, can be used for cold, cold, headache, toothache, nasal congestion and runny nose, rhinitis, nasal abdomen, rheumatism, phlegm and asthma.
  • Pinellia has the effects of dryness, dampness and phlegm, lowering and relieving vomiting, and eliminating pimples.
  • Schisandra has the effect of astringent, astringent, nourishing qi, replenishing qi, nourishing the kidney and calming the heart. Almonds have the effect of relieving cough and asthma, as well as laxative.
  • Roasted licorice has the effect of nourishing qi and nourishing yin, and Tongyang Fumai.
  • the above-mentioned 7-flavored Chinese medicine raw materials cooperate with each other according to the compatibility relationship of "Jun, Chen, Zuo, Shi” and synergistically, so that the Chinese medicine composition can be used for the treatment of Shao Yin disease mechanism syndrome, Taiyin disease mechanism syndrome, and cold syndrome internal injury Disease; or a combination of treatment of internal injury cold stagnation syndrome and exogenous wind cold syndrome.
  • the symptoms include fever or slight fever, coughing, or chills, coldness and warmth, or sweating, nausea, retching, runny nose, and heartburn.
  • the traditional Chinese medicine composition proposed by the present invention is used to treat the syndrome of stagnation. Most of these patients have symptoms of cough and asthma. It is appropriate to use the almond in this scheme to reduce asthma and not use dried ginger. The patient's blood-heating medicine; in addition, the peony-like mild cold, if added, will aggravate the patient's cold symptoms, which is unfavorable for treatment. Therefore, dry ginger and peony are not added to the traditional Chinese medicine composition of the present invention.
  • This embodiment provides a traditional Chinese medicine composition, which includes 5g of ephedra, 15g of twig, 3g of asarum, 15g of pinellia, 10g of schisandra, 9g of almonds, and 10g of licorice root.
  • This embodiment also provides a method for preparing a Chinese medicine composition for treating wind-cold, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for treating wind-cold, relieving muscle and attacking the table, removing stagnation and dispelling drink, and reducing asthma and diarrhea.
  • This embodiment provides a traditional Chinese medicine composition, which includes ephedra 45g, twig 45g, asarum 45g, pinellia 65g, schizandra 40g, almond 30g, and licorice root 45g.
  • This embodiment also provides a method for preparing a Chinese medicine composition for treating wind-cold, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for treating wind-cold, relieving muscle and attacking the table, removing stagnation and dispelling drink, and reducing asthma and diarrhea.
  • This embodiment provides a traditional Chinese medicine composition, which includes ephedra 60g, twig 75g, asarum 18g, pinellia 31g, schisandra 50g, almond 45g, and licorice root 60g.
  • This embodiment also provides a method for preparing a Chinese medicine composition for treating wind-cold, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for treating wind-cold, relieving muscle and attacking the table, removing stagnation and dispelling drink, and reducing asthma and diarrhea.
  • This embodiment provides a traditional Chinese medicine composition, which includes ephedra 38g, twig 63g, asarum 29g, pinellia 75g, schisandra 35g, almond 12g, and licorice 35g.
  • This embodiment also provides a method for preparing a Chinese medicine composition for treating wind-cold, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for treating wind-cold, relieving muscles and attacking tables, removing stagnation and dispelling drinks, and reducing asthma and diarrhea.
  • the present invention also provides the traditional Chinese medicine compositions of Examples 5-10.
  • the traditional Chinese medicine composition can be used to prepare medicines for treating wind-coldness, relieving muscles and attacking tables, removing stagnation and dispelling drinks, and reducing asthma.
  • Table 1 can be prepared by the preparation methods described in Examples 1-4,
  • Table 1 The traditional Chinese medicine compositions provided in Examples 5-10
  • Subjects A total of 408 patients, including 256 male patients and 152 female patients, with an age distribution of 15-75 years old, all patients were due to exogenous wind-induced cold attacks, and the clinical manifestations were typhoid fever. Fever, moisture, nausea, coughing or wheezing under the heart, some accompanied by thirst, or lowering, or urinating is unfavorable, and the abdomen is full of stuffiness.
  • Treatment take the Chinese herbal medicine composition juice of any one of the embodiments 1-10 of the present invention, take it three times in the morning, middle and evening, each time taking 150-350ml, warmly take Qi He, and observe the clinical efficacy.
  • Criteria for curative effect 1) cured, symptoms and signs completely disappeared; 2) markedly effective, most symptoms and signs disappeared after treatment; 3) ineffective, symptoms and signs have not been relieved or even aggravated.
  • the Chinese medicine composition in this scheme under the mutual cooperation and synergistic effect of each specific compatible Chinese herbal medicine component, can cure or relieve the fever or slight fever caused by internal injury and coldness, coughing, or fear Cold, cold and warm, or sweating, nausea and nausea, runny nose, dysphoria, heavy pain around the body, joint pain in the shoulders and shoulders of the extremities; and asthma caused by external cold, or caused by cold cold water
  • rhinitis headache, pharyngitis, rheumatic arthralgia, edema and other related diseases
  • it has obvious curative effects for treating wind-cold, relieving muscles and attacking the table, removing stagnation and dispelling drinks, and lowering and relieving asthma. It is suitable for clinical promotion and application.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une composition de plantes médicinales chinoises pour le traitement de l'asthme, sa méthode de préparation et son utilisation pharmaceutique. La composition de plantes médicinales chinoises est préparée à partir des matières premières de plantes médicinales chinoises suivantes en parties en poids : de 5 à 60 parties d'éphédra, de 15 à 75 parties de rameaux de cassia, de 3 à 45 parties d'asarum, de 15 à 75 parties de rhizoma pinelliae, de 10 à 50 parties de schisandra chinensis, de 9 à 45 parties d'amande et de 10 à 60 parties de racine de réglisse frit au miel. La méthode de préparation comprend les étapes suivantes : le trempage puis la décoction d'éphédra et de rameaux de cassia avec de l'eau pour effectuer une extraction, l'ajout de rameaux de cassia, d'asarum, de schisandra chinensis, d'amande et de racine de réglisse frit au miel dans la soupe et la réalisation d'une nouvelle extraction, et le filtrage pour obtenir un médicament liquide. La composition de médicament a l'action de traiter l'asthme induit par le refroidissement du vent exogène.
PCT/CN2018/117660 2018-11-27 2018-11-27 Composition de plantes médicinales chinoises pour le traitement de l'asthme, sa méthode de préparation et son utilisation pharmaceutique WO2020107210A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201880028354.3A CN111491649A (zh) 2018-11-27 2018-11-27 一种治疗哮喘的中药组合物及其制备方法和制药用途
PCT/CN2018/117660 WO2020107210A1 (fr) 2018-11-27 2018-11-27 Composition de plantes médicinales chinoises pour le traitement de l'asthme, sa méthode de préparation et son utilisation pharmaceutique

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PCT/CN2018/117660 WO2020107210A1 (fr) 2018-11-27 2018-11-27 Composition de plantes médicinales chinoises pour le traitement de l'asthme, sa méthode de préparation et son utilisation pharmaceutique

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100884A (zh) * 2009-12-17 2011-06-22 苏州知微堂生物科技有限公司 一种小青龙汤整合型新剂型制备技术
CN102600265A (zh) * 2012-04-07 2012-07-25 李承平 一组辛温解表的药物组合

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101310746B (zh) * 2007-05-22 2010-12-01 江红旗 止咳平喘外用药物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100884A (zh) * 2009-12-17 2011-06-22 苏州知微堂生物科技有限公司 一种小青龙汤整合型新剂型制备技术
CN102600265A (zh) * 2012-04-07 2012-07-25 李承平 一组辛温解表的药物组合

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
WEI ZHIRUI, JIA SHAOQIAN: "Content Determination of Amygdalin in Maxing Dingchuan Mixture by HPLC", ZHONGGUO YAOYE = CHINA PHARMACEUTICALS, CHONGQING: ZHONGGUO YAOYE ZAZHISHE.,, CN, vol. 18, no. 20, 31 October 2009 (2009-10-31), CN, pages 36 - 37, XP055714141, ISSN: 1006-4931 *
YONGJUN ZHAO: "60 Cases of Bronchial Asthma Treated with Integrated Chinese and Western Medicine", JOURNAL OF EMERGENCY IN TRADITIONAL CHINESE MEDICINE, CHINESE SOCIETY OF TRADITIONAL CHINESE MEDICINE, CN, vol. 12, no. 2, 1 April 2003 (2003-04-01), CN, pages 172, XP055714126, ISSN: 1004-745X *

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