WO2020103412A8 - 包含BPI-Fc嵌合基因的重组腺病毒及其用途 - Google Patents

包含BPI-Fc嵌合基因的重组腺病毒及其用途 Download PDF

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Publication number
WO2020103412A8
WO2020103412A8 PCT/CN2019/087381 CN2019087381W WO2020103412A8 WO 2020103412 A8 WO2020103412 A8 WO 2020103412A8 CN 2019087381 W CN2019087381 W CN 2019087381W WO 2020103412 A8 WO2020103412 A8 WO 2020103412A8
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WO
WIPO (PCT)
Prior art keywords
recombinant adenovirus
application
chimeric gene
bpi
adenovirus containing
Prior art date
Application number
PCT/CN2019/087381
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English (en)
French (fr)
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WO2020103412A1 (zh
Inventor
陈金栋
安云庆
李劲超
杨密清
Original Assignee
厦门联合安金生物工程有限公司
安君(北京)基因科技有限责任公司
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Application filed by 厦门联合安金生物工程有限公司, 安君(北京)基因科技有限责任公司 filed Critical 厦门联合安金生物工程有限公司
Publication of WO2020103412A1 publication Critical patent/WO2020103412A1/zh
Publication of WO2020103412A8 publication Critical patent/WO2020103412A8/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

提供了一种用于治疗耐药革兰氏阴性菌感染的重组腺病毒、其制备及应用。该重组腺病毒包含编码杀菌/渗透增强蛋白(Bactericidal/permeability increasing protein, BPI)和免疫球蛋白重链恒定区Fc的融合蛋白的BPI-Fc嵌合基因。还提供了该重组腺病毒在制备用于治疗耐药革兰氏阴性菌感染的药物组合物中的用途。
PCT/CN2019/087381 2018-11-19 2019-05-17 包含BPI-Fc嵌合基因的重组腺病毒及其用途 WO2020103412A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811374590.9 2018-11-19
CN201811374590.9A CN109762791B (zh) 2018-11-19 2018-11-19 包含BPI-Fc嵌合基因的重组腺病毒及其用途

Publications (2)

Publication Number Publication Date
WO2020103412A1 WO2020103412A1 (zh) 2020-05-28
WO2020103412A8 true WO2020103412A8 (zh) 2020-09-10

Family

ID=66449558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/087381 WO2020103412A1 (zh) 2018-11-19 2019-05-17 包含BPI-Fc嵌合基因的重组腺病毒及其用途

Country Status (2)

Country Link
CN (1) CN109762791B (zh)
WO (1) WO2020103412A1 (zh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1163513C (zh) * 2000-05-22 2004-08-25 首都医科大学 一种高效生产BPI-Fc重组蛋白的方法
CN1733911A (zh) * 2004-08-13 2006-02-15 首都医科大学 一种包含bpi基因的重组病毒及含有其的药物组合物及其用途
CN102168074B (zh) * 2011-02-17 2012-07-25 清华大学 一种重组腺病毒及其应用
KR101719556B1 (ko) * 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물

Also Published As

Publication number Publication date
WO2020103412A1 (zh) 2020-05-28
CN109762791B (zh) 2021-02-09
CN109762791A (zh) 2019-05-17

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