WO2020097706A1 - Composition for treating and dissolving kidney stones - Google Patents

Composition for treating and dissolving kidney stones Download PDF

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Publication number
WO2020097706A1
WO2020097706A1 PCT/BR2019/050487 BR2019050487W WO2020097706A1 WO 2020097706 A1 WO2020097706 A1 WO 2020097706A1 BR 2019050487 W BR2019050487 W BR 2019050487W WO 2020097706 A1 WO2020097706 A1 WO 2020097706A1
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stones
composition
kidney
olive oil
honey
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PCT/BR2019/050487
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French (fr)
Portuguese (pt)
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Antonio ROBERTO NARDINI
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Roberto Nardini Antonio
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Definitions

  • the present invention relates to the pharmaceutical area, more specifically, proposes a composition intended for the treatment of kidney stones or, as is commonly known, kidney stones.
  • the compound consists of common ingredients and popularly known as healthy ingredients and with properties rich in vitamins, oils and proteins.
  • kidney stone is a disease that manifests itself from the formation of crystals in the kidneys and, because of this, the disease is commonly known as kidney stones. Considered one of the worst pains that a human being can feel naturally, the kidney stone occurs mainly due to lack of hydration.
  • kidneys are responsible for filtering the blood, that is, all impurities in the blood are accumulated in the kidneys, which are then eliminated in the form of urine.
  • Another common cause for renal calculus to occur is dehydration, since, without water, urine is more concentrated, facilitating the formation of crystals.
  • the formation of kidney stones is also linked to genetic predisposition and poor diet.
  • kidney stones After the formation of kidney stones, the body tries to eliminate them via the urethra, a channel that connects the kidneys to the bladder. When the stones are in the urethra, depending on their size, they are retained in the body. When the body tries to release this accumulation, contractions are common, which causes the pain that is characteristic of kidney stones. Another source of pain is the swelling of the kidneys that occurs when the stone is trapped in the urethral canal, causing urine to accumulate in the kidney. Because of this, the medical recommendation is that, when there is already the pain caused by the dilation of the kidneys, do not drink too much water, as it would make the kidneys work harder, producing more urine, and forcing more the stone to exit through the canal, which would further dilate the kidney.
  • One of the ways to avoid kidney stones is the annual visit to a urologist and good nutrition and hydration. This means that, even with the formation of stones, they can be eliminated naturally by the body, without pain, contractions and dilation of the kidneys.
  • kidney stones There are different ways to treat and eliminate kidney stones. From home treatments to surgical procedures to eliminate calculations from the patient's body. The surgical procedure is usually taken into consideration when the patient is no longer able to eliminate the stone by natural means, or by the size of the stone, or by some difficulty in the organism of the same. When it reaches this point, the patient already has severe abdominal pain, coming to be compared with labor pain and it is still common for the patient to have fever and weakness at that time, as well as nausea and leading to the patient's fainting.
  • the surgical procedure is aimed at removing the stone or just reducing it to be eliminated naturally by the body.
  • three different types of surgery are technically knowledgeable.
  • the procedure known as “extracorporeal lithotripsy” uses a emitting shock waves to fragment the stone and thus the body expels via urine.
  • the procedure known as “percutaneous nephrolithotripsy” is done through a small incision through which the kidney is reached. Then, a device that destroys and removes the kidney stone is introduced into the patient's body.
  • the known procedure “Ureterolitotripsia” uses an endoscope inserted in the urethra to fragment and remove the stone. The surgery is only performed after consultation with a specialist doctor and he decides that the only solution is surgical intervention.
  • the patient may be able to eliminate the stone naturally, without the aid of any compositions or treatment. This occurs when the stone is not fully formed, being eliminated in pieces in the urine, or when the formed stone passes through the urethral canal without damaging or locking the canal. However, bleeding may occur even in natural elimination, as the stones may have sharp edges, which cause damage to the urethra.
  • the present patent application proposes an innovative compound that comprises natural components with amounts of Apple Cider Vinegar, Olive Oil and Honey for the treatment and prevention of kidney stones.
  • This compound being ingested in capsule format, preferably in gel, can perform a complete treatment, avoiding pain and other disorders or discomfort for the patient.
  • the compound differs from drugs known in the market for presenting a natural composition, making the treatment safer and avoiding side effects, since the patient will not ingest chemical compounds that can cause other health problems.
  • Another objective of the invention is to perform the complete treatment of the kidney stone for 10 to 20 days, ingesting the natural capsule 2 to 4 times a day.
  • the compound proposed by the present invention patent basically provides sufficient amounts of Vinegar, olive oil and honey. Preferably, this composition should be administered to patients through gel capsules.
  • composition proposed in the present patent application comprises vinegar in the amount of 25 - 40% by volume, Olive Oil in the amount of 25 - 40% in volume and Honey in the amount of 25 - 40% in volume.
  • the present invention proposes a composition comprising 33.33% Vinegar, 33.33% honey and 33.33% olive oil.
  • the compound should be presented to the patient in gel capsules to be properly ingested.
  • patients should ingest this compound in a period of 10 to 20 days, ingesting the natural capsule 2 to 4 times a day.
  • this compound should be ingested three times a day, in a treatment lasting fifteen days.
  • the natural remedy can treat and prevent the disease known as kidney stones, or, as it is commonly known, the presence of kidney stones.
  • Apple Cider Vinegar is known to have a high acidity, with pH around 2.5 to 4.0 and, because of that, it is popular and technical knowledge that Apple Cider Vinegar has several advantages to the human body , and can be used on different occasions, even to dissolve kidney stones. It is understood that acidity can prevent the formation of stones, it is even recommended to take only diluted in water for prevention. In addition, it is known that, depending on the acidity level, Apple Cider Vinegar can dilute small kidney stones. In addition, the acidity of Apple Cider Vinegar helps to dilute calcium and other elements that may be present in the kidneys, forming salts and solids that can cause kidney stones.
  • Olive oil especially olive oil, is known as a natural lubricant for the body and is commonly used to aid in inflammatory diseases and natural weight loss.
  • vitamin E which prevents different types of diseases is known as a natural antioxidant, maintaining the pH of the human body and preventing degenerative diseases such as cancer.
  • the intake of olive oil helps the human body to absorb fat-soluble vitamins, which are vitamins A, D, E and K.
  • the lubrication that olive oil provides helps in the treatment of cardiovascular diseases is still a feature that helps in the elimination of kidney stones, given that the channels are better lubricated.
  • the ingestion of olive oil helps to maintain the kidneys at the time the stone is trapped in the channels, locking the urine produced in the kidneys, dilating and causing cramps to the patient. That is, the oil allows the passage of this stone to be aided by the lubrication of the channel.
  • olive oil also consists of an acidic component, with a pH defined between 5.0 and 6.0, which, because it is also a compound with known acidity, helps in the dissolution of the stones.
  • honey is rich in vitamins that help prevent disease. It is commonly used in natural teas to treat venereal and allergic diseases.
  • Honey comprises vitamin A, which prevents the formation of kidney stones, in addition to helping the lining of the urinary tract. In addition, vitamin A contained in honey assists in tissue healing.
  • Honey also includes vitamin B2, which aids in the absorption of vitamins B1 and B6, in addition to assisting in the healing of wounds that may occur due to kidney stones.
  • Honey also comprises vitamin B5, responsible for improving the healing of minor injuries, and vitamin B6, which reduces the concentration of oxalate in the urine, one of the responsible for the formation of kidney stones.
  • honey also comprises vitamin C, commonly known as an aid in diseases venereal, but also against inflammation, and comprises vitamin H, which helps the body absorb vitamins and ores.
  • honey has a defined pH between 3.0 and 4.5, which also plays a role in helping to dissolve stones.
  • these three ingredients can perform a complete treatment when related to the kidney stone, helping in the dissolution of the stone, due to the acidity of Apple Vinegar.
  • the composition helps in the healing of wounds that occur when the stone passes through the urethral canal, due to the vitamins present in olive oil and honey.
  • the composition helps in the treatment of kidney inflammation, by the oil and vitamins present in honey, as well as in the elimination of the stone through the urethra channel, due to the lubrication that the oil contained in the composition can offer. .
  • the composition may be preferably with 2/3 ml of Apple Cider Vinegar, 2/3 ml of Extra Virgin Olive Oil and 2/3 of Honey to form a 2 ml capsule, preferably in gel.
  • the treatment preferably, would be the ingestion of this capsule 3 times a day for 15 consecutive days. With that, the treatment for kidney stones would be complete, eliminating the stones, lubricating the channels and aiding the healing of the damaged walls by the stone and helping to deflate the kidneys.
  • kidney stones are solid structures that result from the agglomeration of crystals that are formed due to a metabolic alteration in the body.
  • the chemical composition of the crystals determines the type of calculation formed.
  • there are several types of calculations such as calcium oxalate, calcium oxalate associated with calcium phosphate, uric acid, struvite, calcium phosphate and cystine, among other components.
  • calcium calculations are the most common, since calcium can combine with other substances, such as oxalate, phosphate or carbonate to form the kidney stone.
  • the composition proposed in the present patent application due to its acidic nature, has an effect on these formations, due to the chemical reactions that occur and can solubilize the crystal formed in the organism.
  • composition that comprises components with a known acidity level
  • this composition has the expected effect of dissolving the stones, considering that its ingestion should increase the urine pH. Therefore, the composition helps to create an alkaline environment by increasing the pH, preventing uric acid from crystallizing.

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Abstract

The invention relates to a composition intended for treating kidney stones. The compound is made up of common ingredients that are popularly known to be healthy ingredients with vitamin-, oil- and protein-rich properties, and envisages the use of vinegar in quantities of 25-40% by volume, olive oil in quantities of 25-40% by volume and honey in quantities of 25-40% by volume. The compound is to be ingested by the patient in gel capsules. Said ingredients can be used for a complete treatment of kidney stones, helping to dissolve the stones, owing to the acidity of the vinegar, and to heal lesions that arise as a result of the stones passing through the urethral canal, owing to the vitamins present in the olive oil and honey. The invention helps to treat kidney inflammation since it contains olive oil and vitamins present in the honey, and also to eliminate the stones through the urethral canal as a result of lubrication from the olive oil.

Description

COMPOSIÇÃO PARA TRATAMENTO E DISSOLUÇÃO DE  COMPOSITION FOR TREATMENT AND DISSOLUTION OF
CÁLCULOS RENAIS  KIDNEY CALCULATIONS
Setor tecnológico da invenção  Technological sector of the invention
[001 ] A presente invenção refere-se à área farmacêutica, mais especificamente, propõe uma composição destinada ao tratamento de cálculo renal ou, como é comumente conhecido, pedras nos rins. O composto é constituído por ingredientes comuns e conhecidos popularmente como ingredientes saudáveis e com propriedades ricas em vitaminas, óleos e proteínas.  [001] The present invention relates to the pharmaceutical area, more specifically, proposes a composition intended for the treatment of kidney stones or, as is commonly known, kidney stones. The compound consists of common ingredients and popularly known as healthy ingredients and with properties rich in vitamins, oils and proteins.
Estado da Técnica Conhecido  Known State of the Art
[002] O cálculo renal é uma doença que se manifesta a partir da formação de cristais nos rins e, por conta disso, a doença é comumente conhecida como pedras nos rins. Considerada uma das piores dores que um ser humano possa sentir de forma natural, a pedra nos rins ocorre, principalmente, por falta de hidratação.  [002] The kidney stone is a disease that manifests itself from the formation of crystals in the kidneys and, because of this, the disease is commonly known as kidney stones. Considered one of the worst pains that a human being can feel naturally, the kidney stone occurs mainly due to lack of hydration.
[003] Segundo a GBD 2015 Disease and Injury Incidence and Prevalence, em 2015, mais de 20 milhões de pessoas apresentaram a existência de cálculos renair, e, segundo David Schulsinger, em seu livro“Kidney Stone Disease: Say NO to Stones!”, as primeiras ocorrências de pedras nos rins são datadas no ano de 600 a.C.  [003] According to GBD 2015 Disease and Injury Incidence and Prevalence, in 2015, more than 20 million people presented the existence of renair calculations, and, according to David Schulsinger, in his book “Kidney Stone Disease: Say NO to Stones!” , the first occurrences of kidney stones are dated to 600 BC
[004] Os rins são órgãos responsáveis por filtrar o sangue, ou seja, todas as impurezas do sangue são acumuladas nos rins, que depois são eliminadas na forma de urina. Alguns urologistas afirmam que a principal causa do cálculo renal é um erro no metabolismo do rim na filtração do sangue. Esse mal funcionamento dos rins faz com que os mesmos filtrem do sangue cálcio e oxalato, eliminando-os na urina. Com o tempo, essas substâncias se acumulam e formam os conhecidos cálculos renais, ou seja, as chamadas pedras nos rins. Outra causa comum para que se ocorra o cálculo renal, é a desidratação, uma vez que, sem água, a urina é mais concentrada, facilitando a formação de cristais. Além disso, cabe destacar que a formação de cálculos renais está ligada, também, a predisposição genética e a má alimentação. [004] The kidneys are responsible for filtering the blood, that is, all impurities in the blood are accumulated in the kidneys, which are then eliminated in the form of urine. Some urologists claim that the main cause of kidney stones is an error in the kidney's metabolism in blood filtration. This malfunction of the kidneys causes them to filter calcium and oxalate from the blood, eliminating them in the urine. Over time, these substances accumulate and form the known kidney stones, that is, the so-called kidney stones. Another common cause for renal calculus to occur is dehydration, since, without water, urine is more concentrated, facilitating the formation of crystals. In addition, it should be noted that the formation of kidney stones is also linked to genetic predisposition and poor diet.
[005] Depois da formação das pedras nos rins, o organismo tenta elimina-las via uretra, canal que liga os rins até a bexiga. Quando as pedras estão na uretra, dependendo de seu tamanho, ficam retidas no organismo. Quando o organismo tenta liberar esse acumulo, é comum ocorrer contrações, o que causa a dor característica dos cálculos renais. Outra fonte da dor é o inchaço dos rins que ocorre quando a pedra está presa no canal uretra, fazendo com que a urina se acumule no rim. Por conta disso, a recomendação médica é que, quando já existe a presença da dor causada pela dilatação dos rins, não se tome muita água, uma vez que faria com que os rins trabalhassem mais, produzindo mais urina, e forçando mais a cálculo a sair pelo canal, o que dilataria mais o rim. Uma das formas de evitar as pedras nos rins é a visita anual a um urologista e uma boa alimentação e hidratação. Isso faz com que, mesmo com a formação de pedras, elas possam ser eliminadas naturalmente pelo organismo, sem dor, contrações e dilatação dos rins.  [005] After the formation of kidney stones, the body tries to eliminate them via the urethra, a channel that connects the kidneys to the bladder. When the stones are in the urethra, depending on their size, they are retained in the body. When the body tries to release this accumulation, contractions are common, which causes the pain that is characteristic of kidney stones. Another source of pain is the swelling of the kidneys that occurs when the stone is trapped in the urethral canal, causing urine to accumulate in the kidney. Because of this, the medical recommendation is that, when there is already the pain caused by the dilation of the kidneys, do not drink too much water, as it would make the kidneys work harder, producing more urine, and forcing more the stone to exit through the canal, which would further dilate the kidney. One of the ways to avoid kidney stones is the annual visit to a urologist and good nutrition and hydration. This means that, even with the formation of stones, they can be eliminated naturally by the body, without pain, contractions and dilation of the kidneys.
[006] Existem diferentes maneiras de se tratar e eliminar as pedras nos rins. Desde tratamentos caseiros até procedimento cirúrgico para eliminar os cálculos do organismo do paciente. O procedimento cirúrgico, geralmente, é levado em consideração quando o paciente não consegue mais eliminar a pedra por vias naturais, ou pelo tamanho da pedra, ou por alguma dificuldade do organismo do mesmo. Quando chega a esse ponto, o paciente já apresenta dores abdominais fortes, chegando a ser comparado com a dor de parto e ainda é comum o paciente apresentar febre e fraqueza nesse momento, bem como náuseas e levando até o desmaio do paciente.  [006] There are different ways to treat and eliminate kidney stones. From home treatments to surgical procedures to eliminate calculations from the patient's body. The surgical procedure is usually taken into consideration when the patient is no longer able to eliminate the stone by natural means, or by the size of the stone, or by some difficulty in the organism of the same. When it reaches this point, the patient already has severe abdominal pain, coming to be compared with labor pain and it is still common for the patient to have fever and weakness at that time, as well as nausea and leading to the patient's fainting.
[007] Portanto, o procedimento cirúrgico é voltado a retirada da pedra ou apenas a diminuição da mesma para ser eliminada naturalmente pelo organismo. Com isso, são de conhecimento técnico três tipos diferentes de cirurgia. O procedimento conhecido como“Litotripsia extracorpórea” usa um emissor de ondas de choque para fragmentar a pedra e, assim, o organismo expelir via urina. O procedimento conhecido como“ Nefrolitotripsia percutânea” é feita por meio de uma pequena incisão pela qual se chega ao rim. Depois, é introduzido no organismo do paciente um aparelho que destrói e remove o cálculo renal. Por fim, o procedimento conhecido“Ureterolitotripsia” utiliza um endoscópio inserido na uretra para fragmentar e remover a pedra. A cirurgia só é realizada após a consulta a um médico especialista e este definir que a única solução é a intervenção cirúrgica. [007] Therefore, the surgical procedure is aimed at removing the stone or just reducing it to be eliminated naturally by the body. With that, three different types of surgery are technically knowledgeable. The procedure known as “extracorporeal lithotripsy” uses a emitting shock waves to fragment the stone and thus the body expels via urine. The procedure known as "percutaneous nephrolithotripsy" is done through a small incision through which the kidney is reached. Then, a device that destroys and removes the kidney stone is introduced into the patient's body. Finally, the known procedure “Ureterolitotripsia” uses an endoscope inserted in the urethra to fragment and remove the stone. The surgery is only performed after consultation with a specialist doctor and he decides that the only solution is surgical intervention.
[008] Caso o paciente não necessite de procedimento cirúrgico, existe no mercado alguns compridos que auxiliam na eliminação natural das pedras. Mas também há a opção de tratamento caseiro, com ingredientes comuns, encontrados em qualquer estabelecimento. O mais comum é o Vinagre de Maçã, que, por suas propriedades ácidas, tem a capacidade de dissolver a pedra e prevenir que o rim forme os cálculos. É de conhecimento também que, o azeite de Oliva, por ser um lubrificante natural, auxilia na eliminação das pedras de forma natural, uma vez que este lubrifica o canal da uretra e a pedra possa ser expelido naturalmente. No mercado farmacêutico são encontrados diferentes medicamentos para o tratamento de pedra nos rins, mas, nenhum desses compreende ingredientes naturais. Ademais, são raros os que servem especificamente para eliminar ou prevenir as pedras.  [008] If the patient does not need a surgical procedure, there are some lengths on the market that help in the natural elimination of stones. But there is also the option of homemade treatment, with common ingredients, found in any establishment. The most common is Apple Cider Vinegar, which, due to its acidic properties, has the ability to dissolve the stone and prevent the kidney from forming stones. It is also known that olive oil, as a natural lubricant, helps to eliminate stones in a natural way, since it lubricates the urethra channel and the stone can be expelled naturally. In the pharmaceutical market different drugs are found for the treatment of kidney stones, but none of these comprise natural ingredients. In addition, rare are those that specifically serve to eliminate or prevent stones.
[009] Além de receitas caseiras, são encontrados no mercado atual, diversos medicamentos diferentes para o tratamento e prevenção de pedras nos rins. Tais medicamentos com compostos químicos, que, eventualmente podem causar efeitos colaterais e/ou danos em demais órgãos do corpo humano, como é de conhecimento para um técnico no assunto. É de conhecimento, também, que alguns compostos químicos podem causar doenças, por exemplo a hepatite que ocorre no fígado por ingestão de compostos químicos que podem estar presentes em diferentes medicamentos e bebidas alcoólicas. Também é de conhecimento para um técnico no assunto que um medicamento compreendendo compostos químicos pode causar ataques alérgicos que podem ocasionar desde simples manchas até o óbito do paciente, caso ingerido de maneira errada. [009] In addition to homemade recipes, several different drugs are found in the current market for the treatment and prevention of kidney stones. Such drugs with chemical compounds, which, eventually, can cause side effects and / or damage to other organs of the human body, as is known to a technician in the subject. It is also known that some chemical compounds can cause diseases, for example hepatitis that occurs in the liver due to the ingestion of chemical compounds that may be present in different medications and alcoholic beverages. It is also known to a technician in the subject that a drug understanding chemical compounds can cause allergic attacks that can cause everything from simple spots to the death of the patient, if ingested in the wrong way.
[010] Apesar de raramente ocorrer, o paciente pode conseguir eliminar a pedra naturalmente, sem auxílio de quaisquer composições ou tratamento. Isso ocorre quando a pedra não é formada integralmente, sendo eliminada em pedaços na urina, ou, quando a pedra formada passa pelo canal da uretra sem danificar ou trancar o canal. Porém pode vir a ocorrer sangramento mesmo na eliminação natural, pois os cálculos podem apresentar arestas, o que causa danos na uretra.  [010] Although it rarely occurs, the patient may be able to eliminate the stone naturally, without the aid of any compositions or treatment. This occurs when the stone is not fully formed, being eliminated in pieces in the urine, or when the formed stone passes through the urethral canal without damaging or locking the canal. However, bleeding may occur even in natural elimination, as the stones may have sharp edges, which cause damage to the urethra.
[01 1 ] Para realizar um tratamento com ingredientes naturais, o documento de patente chinesa n. CN106107303, intitulado como“Apple Vi negar beverage and preparation Method thereof’ descreve um vinagre de maçã e seu respectivo processo de produção, prevendo ainda que esse vinagre possui características nutritivas aos rins. Entretanto, tal documento não prevê um componente oleoso em sua composição e nem mesmo uma composição destinada ao tratamento de pedras nos rins. Ou seja, a solução descrita no documento de patente em questão não utiliza nenhum óleo ou substância lubrificante para agir nos canais da uretra e nem mesmo a adição de mel à composição para tratamento de cálculos renais.  [01 1] To carry out a treatment with natural ingredients, Chinese patent document no. CN106107303, entitled “Apple Vi deny beverage and preparation Method thereof” describes an apple cider vinegar and its respective production process, further providing that this vinegar has nutritional characteristics for the kidneys. However, this document does not include an oily component in its composition or even a composition intended for the treatment of kidney stones. In other words, the solution described in the patent document in question does not use any oil or lubricating substance to act in the channels of the urethra or even the addition of honey to the composition to treat kidney stones.
[012] Na internet são encontrados diversos artigos ensinando a preparar receitas caseiras para o tratamento ou prevenção de cálculos renais. Nesse contexto, apesar de preverem o uso de Vinagre e Azeite como lubrificante, nenhum desses artigos apresentou o Mel como ingrediente importante da receita e, com isso, os compostos apresentam falta das vitaminas que o Mel proporciona ao corpo humano e que auxiliam na eliminação, quebra ou prevenção das pedras nos rins.  [012] There are several articles on the internet teaching how to prepare homemade recipes for the treatment or prevention of kidney stones. In this context, although they foresee the use of Vinegar and Olive Oil as a lubricant, none of these articles presented Honey as an important ingredient in the recipe and, with this, the compounds lack the vitamins that Honey provides to the human body and that aid in the elimination, breaking or preventing kidney stones.
[013] Assim sendo, se pode concluir que, atualmente não se conhece nenhum documento que mostra o uso de Vinagre, Azeite e Mel para produção de um composto, que possa efetivamente eliminar, quebrar e prevenir a formação de cálculos renais. Ademais, não foram apresentados medicamentos naturais com tal composição, forçando os médicos a indicar geralmente tratamentos a partir de medicamentos químicos ou ainda a partir de procedimentos cirúrgicos e invasivos. [013] Therefore, it can be concluded that, currently, no document is known that shows the use of Vinegar, Olive Oil and Honey for the production of a compound, which can effectively eliminate, break and prevent the formation of kidney stones. In addition, natural medicines with such a composition were not presented, forcing doctors to generally recommend treatments based on chemical drugs or even on surgical and invasive procedures.
Objetivo da Invenção  Purpose of the Invention
[014] O presente pedido de patente de invenção propõe um composto inovador que compreende componentes naturais com quantidades de Vinagre de Maçã, Azeite e Mel para o tratamento e prevenção de cálculo renal.  [014] The present patent application proposes an innovative compound that comprises natural components with amounts of Apple Cider Vinegar, Olive Oil and Honey for the treatment and prevention of kidney stones.
[015] Esse composto, sendo ingerido em formato de cápsulas, preferencialmente em gel, pode realizar um tratamento completo, evitando dores e demais transtornos ou desconfortos para o paciente. Ademais, o composto se diferencia dos medicamentos conhecidos no mercado por apresentar uma composição natural, fazendo com que o tratamento seja mais seguro e evite efeitos colaterais, uma vez que o paciente não irá ingerir compostos químicos que podem causar outros problemas de saúde.  [015] This compound, being ingested in capsule format, preferably in gel, can perform a complete treatment, avoiding pain and other disorders or discomfort for the patient. In addition, the compound differs from drugs known in the market for presenting a natural composition, making the treatment safer and avoiding side effects, since the patient will not ingest chemical compounds that can cause other health problems.
[016] Por fim, outro objetivo da invenção é realizar o tratamento completo do cálculo renal de 10 a 20 dias, ingerindo a cápsula natural de 2 a 4 vezes ao dia.  [016] Finally, another objective of the invention is to perform the complete treatment of the kidney stone for 10 to 20 days, ingesting the natural capsule 2 to 4 times a day.
Descrição detalhada da invenção Detailed description of the invention
[017] O composto proposto pela presente patente de invenção prevê basicamente quantidades suficientes de Vinagre, azeite e mel. Preferencialmente essa composição deverá ser ministrada aos pacientes através de cápsulas em gel.  [017] The compound proposed by the present invention patent basically provides sufficient amounts of Vinegar, olive oil and honey. Preferably, this composition should be administered to patients through gel capsules.
[018] De maneira geral, a composição proposta no presente pedido de patente compreende de vinagre na quantidade de 25 - 40% em volume, Azeite de Oliva na quantidade de 25 - 40% em volume e Mel na quantidade de 25 - 40% em volume.  [018] In general, the composition proposed in the present patent application comprises vinegar in the amount of 25 - 40% by volume, Olive Oil in the amount of 25 - 40% in volume and Honey in the amount of 25 - 40% in volume.
[019] De forma mais específica, a presente invenção propõe uma composição que compreende 33,33% de Vinagre, 33,33% de mel e 33,33% de azeite. [020] O composto deverá ser apresentado ao paciente em cápsulas em gel para serem devidamente ingeridas. Preferencialmente, os pacientes devem ingerir esse composto em um período de 10 a 20 dias, ingerindo a cápsula natural de 2 a 4 vezes ao dia. Mais preferencialmente ainda, esse composto deverá ser ingerido três vezes ao dia, em um tratamento com duração de quinze dias. Com isso, o remédio natural pode tratar e prevenir a doença conhecida como cálculo renal, ou, como é comumente conhecida, a presença de pedras nos rins. [019] More specifically, the present invention proposes a composition comprising 33.33% Vinegar, 33.33% honey and 33.33% olive oil. [020] The compound should be presented to the patient in gel capsules to be properly ingested. Preferably, patients should ingest this compound in a period of 10 to 20 days, ingesting the natural capsule 2 to 4 times a day. Most preferably, this compound should be ingested three times a day, in a treatment lasting fifteen days. With this, the natural remedy can treat and prevent the disease known as kidney stones, or, as it is commonly known, the presence of kidney stones.
[021 ] Uma alternativa preferencial prevê, especificamente, o uso de vinagre de maçã na composição. Sendo assim, a presente invenção propõe uma composição compreendendo vinagre de maçã na quantidade de 25 - 40% em volume, Azeite de Oliva na quantidade de 25 - 40% em volume e Mel na quantidade de 25 - 40% em volume. Mais especificamente a presente composição proposta prevê 33,33% de vinagre de maçã, 33,33% de azeite de oliva e 33,33% de mel. Ademais, pode-se destacar que a presente composição compreende pH definido entre 3,0 e 6,0.  [021] A preferred alternative specifically provides for the use of apple cider vinegar in the composition. Therefore, the present invention proposes a composition comprising apple cider vinegar in the amount of 25 - 40% by volume, Olive Oil in the amount of 25 - 40% in volume and Honey in the amount of 25 - 40% in volume. More specifically, the proposed composition provides for 33.33% apple cider vinegar, 33.33% olive oil and 33.33% honey. In addition, it can be noted that the present composition comprises a pH defined between 3.0 and 6.0.
[022] O Vinagre de Maçã é conhecido por ter uma acidez elevada, com pH em torno de 2,5 a 4,0 e, por conta disso, é de conhecimento popular e técnico que o Vinagre de Maçã apresenta diversas vantagens ao corpo humano, podendo ser usado em diferentes ocasiões, até para dissolver pedras nos rins. É entendido que a acidez pode prevenir a formação das pedras, sendo até recomendado tomar apenas diluído em água para a prevenção. Além disso, é de conhecimento técnico que, dependendo do nível de acidez, o Vinagre de Maçã pode chegar a diluir pequenos cálculos renais. Ademais, a acidez do Vinagre de Maçã ajuda na diluição do cálcio e outros elementos que podem estar presentes nos rins, formando sais e sólidos que podem ocasionar o cálculo renal.  [022] Apple Cider Vinegar is known to have a high acidity, with pH around 2.5 to 4.0 and, because of that, it is popular and technical knowledge that Apple Cider Vinegar has several advantages to the human body , and can be used on different occasions, even to dissolve kidney stones. It is understood that acidity can prevent the formation of stones, it is even recommended to take only diluted in water for prevention. In addition, it is known that, depending on the acidity level, Apple Cider Vinegar can dilute small kidney stones. In addition, the acidity of Apple Cider Vinegar helps to dilute calcium and other elements that may be present in the kidneys, forming salts and solids that can cause kidney stones.
[023] O azeite, especialmente o azeite de oliva, é conhecido como um lubrificante natural do organismo, sendo usado, comumente para o auxílio em doenças inflamatórias e no emagrecimento natural. Além de ser uma fonte de vitamina E, que previne diferentes tipos de doenças é conhecido como um antioxidante natural, fazendo a manutenção de pH do corpo humano e prevenir doenças degenerativas, como o câncer. Ademais, a ingestão de azeite auxilia o corpo humano a absorver vitaminas lipossolúveis, que são as vitaminas A, D, E e K. [023] Olive oil, especially olive oil, is known as a natural lubricant for the body and is commonly used to aid in inflammatory diseases and natural weight loss. In addition to being a source of vitamin E, which prevents different types of diseases is known as a natural antioxidant, maintaining the pH of the human body and preventing degenerative diseases such as cancer. In addition, the intake of olive oil helps the human body to absorb fat-soluble vitamins, which are vitamins A, D, E and K.
[024] Ademais, a lubrificação que o azeite proporciona auxilia no tratamento de doenças cardiovasculares ainda é uma característica que auxilia na eliminação de pedras nos rins, tendo em vista que os canais são melhores lubrificados. Por fim, por apresentar característica anti-inflamatória, a ingestão de azeite auxilia na manutenção dos rins no momento em que a pedra está presa nos canais, trancando a urina produzida nos rins, dilatando e causando cólicas ao paciente. Ou seja, o azeite permite que o a passagem dessa pedra seja auxiliada pela lubrificação do canal. Por fim, cabe ainda salientar que o azeite de oliva consiste ainda em um componente ácido, apresentando pH definido entre 5,0 e 6,0 que, por também se tratar de um composto com acidez conhecida, auxilia na dissolução dos cálculos.  [024] In addition, the lubrication that olive oil provides helps in the treatment of cardiovascular diseases is still a feature that helps in the elimination of kidney stones, given that the channels are better lubricated. Finally, because it has an anti-inflammatory characteristic, the ingestion of olive oil helps to maintain the kidneys at the time the stone is trapped in the channels, locking the urine produced in the kidneys, dilating and causing cramps to the patient. That is, the oil allows the passage of this stone to be aided by the lubrication of the channel. Finally, it should also be noted that olive oil also consists of an acidic component, with a pH defined between 5.0 and 6.0, which, because it is also a compound with known acidity, helps in the dissolution of the stones.
[025] Além de ser conhecido como um adoçante natural, o Mel é rico em vitaminas que auxiliam na prevenção de doenças. É comumente usado em chás naturais para o tratamento de doenças venéreas e alérgicas. O mel compreende vitamina A, que previne a formação dos cálculos renais, além de auxiliar no revestimento do trato urinário. Ademais, a vitamina A contida no mel auxilia na cicatrização de tecidos. O mel compreende também vitamina B2, que auxilia na absorção das vitaminas B1 e B6, além de auxiliar na cicatrização de feridas que podem ocorrer devido a pedra no rim. O mel também compreende vitamina B5, responsável por melhorar a cicatrização de ferimentos leves, e a vitamina B6, que reduz a concentração de oxalato na urina, um dos responsáveis pela formação das pedras nos rins. Por fim, o mel também compreende vitamina C, comumente conhecido como auxiliar em doenças venéreas, mas também contra inflamações, e compreende vitamina H, que auxilia na absorção de vitaminas e minérios pelo organismo. Ademais, o mel apresenta pH definido entre 3,0 e 4,5, que também apresenta papel em auxiliar na dissolução dos cálculos. [025] In addition to being known as a natural sweetener, honey is rich in vitamins that help prevent disease. It is commonly used in natural teas to treat venereal and allergic diseases. Honey comprises vitamin A, which prevents the formation of kidney stones, in addition to helping the lining of the urinary tract. In addition, vitamin A contained in honey assists in tissue healing. Honey also includes vitamin B2, which aids in the absorption of vitamins B1 and B6, in addition to assisting in the healing of wounds that may occur due to kidney stones. Honey also comprises vitamin B5, responsible for improving the healing of minor injuries, and vitamin B6, which reduces the concentration of oxalate in the urine, one of the responsible for the formation of kidney stones. Finally, honey also comprises vitamin C, commonly known as an aid in diseases venereal, but also against inflammation, and comprises vitamin H, which helps the body absorb vitamins and ores. In addition, honey has a defined pH between 3.0 and 4.5, which also plays a role in helping to dissolve stones.
[026] Por causa dessas características individuais, esses três ingredientes podem realizar um tratamento completo quando relacionado com o cálculo renal, auxiliando na dissolução da pedra, por conta da acidez do Vinagre de Maçã. Ademais a composição auxilia na cicatrização de feridas ocorridas pela passagem da pedra pelo canal da uretra, por conta das vitaminas presentes no azeite e no mel. Por fim, pode-se se destacar ainda que a composição auxilia no tratamento da inflamação do rim, pelo azeite e vitaminas presentes no mel, bem na eliminação da pedra pelo canal da uretra, por conta da lubrificação que o azeite contido na composição pode oferecer.  [026] Because of these individual characteristics, these three ingredients can perform a complete treatment when related to the kidney stone, helping in the dissolution of the stone, due to the acidity of Apple Vinegar. In addition, the composition helps in the healing of wounds that occur when the stone passes through the urethral canal, due to the vitamins present in olive oil and honey. Finally, it can be highlighted that the composition helps in the treatment of kidney inflammation, by the oil and vitamins present in honey, as well as in the elimination of the stone through the urethra channel, due to the lubrication that the oil contained in the composition can offer. .
[027] Para tal tratamento, sugere-se uma formulação em cápsula dos componentes previamente citados. A composição poderá ser, preferencialmente, com 2/3 ml de Vinagre de Maçã, 2/3 ml de Azeite de Oliva Extra Virgem e 2/3 de Mel para que formule uma cápsula, preferencialmente em gel, de 2 ml. O tratamento, preferencialmente, seria a ingestão dessa cápsula 3 vezes ao dia durante 15 dias seguidos. Com isso, o tratamento para cálculos renais estaria completo, eliminando os cálculos, lubrificando os canais e auxiliando na cicatrização das paredes danificas pelo cálculo e auxiliando à desinchar os rins.  [027] For such treatment, a capsule formulation of the previously mentioned components is suggested. The composition may be preferably with 2/3 ml of Apple Cider Vinegar, 2/3 ml of Extra Virgin Olive Oil and 2/3 of Honey to form a 2 ml capsule, preferably in gel. The treatment, preferably, would be the ingestion of this capsule 3 times a day for 15 consecutive days. With that, the treatment for kidney stones would be complete, eliminating the stones, lubricating the channels and aiding the healing of the damaged walls by the stone and helping to deflate the kidneys.
[028] Por fim, destaca-se que os cálculos renais são estruturas sólidas que resultam da aglomeração de cristais que se formam devido a uma alteração metabólica do organismo. A composição química dos cristais determina o tipo de cálculo formado. Assim, existem vários tipos de cálculos, como os de oxalato de cálcio, de oxalato de cálcio associado a fosfato de cálcio, ácido úrico, estruvite, fosfato de cálcio e cistina, entre outros componentes. Ademais, sabe- se que os cálculos de cálcio são os mais comuns, visto que, o cálcio pode combinar-se com outras substâncias, como o oxalato, o fosfato ou o carbonato para formar a pedra nos rins. Nesse sentido, pode-se verificar que a composição proposta no presente pedido de patente, devido à sua natureza ácida, tem efeito sobre essas formações, devido às reações químicas que ocorrem e podem solubilizar o cristal formado no organismo. [028] Finally, it should be noted that kidney stones are solid structures that result from the agglomeration of crystals that are formed due to a metabolic alteration in the body. The chemical composition of the crystals determines the type of calculation formed. Thus, there are several types of calculations, such as calcium oxalate, calcium oxalate associated with calcium phosphate, uric acid, struvite, calcium phosphate and cystine, among other components. In addition, it is known that calcium calculations are the most common, since calcium can combine with other substances, such as oxalate, phosphate or carbonate to form the kidney stone. In this sense, it can be seen that the composition proposed in the present patent application, due to its acidic nature, has an effect on these formations, due to the chemical reactions that occur and can solubilize the crystal formed in the organism.
[029] Nesse contexto, ao propor uma composição que compreende componentes com nível acidez conhecido, é previsto que essa composição apresenta o efeito esperado de dissolução dos cálculos, tendo em vista que sua ingestão deve aumentar o pH da urina. Assim sendo, a composição ajuda a criar um ambiente alcalino ao aumentar o pH, evitando que o ácido úrico se cristalize.  [029] In this context, when proposing a composition that comprises components with a known acidity level, it is expected that this composition has the expected effect of dissolving the stones, considering that its ingestion should increase the urine pH. Therefore, the composition helps to create an alkaline environment by increasing the pH, preventing uric acid from crystallizing.
[030] Tratou-se no presente relatório descritivo de um composto para tratamento de cálculo renal proporcionando a disponibilização de um remédio natural em cápsulas, dotado de novidade, atividade inventiva, suficiência descritiva, aplicação industrial e, consequentemente, revestido de todos os requisitos essenciais para a concessão do privilégio pleiteado.  [030] This specification describes a compound for the treatment of kidney stones, providing the availability of a natural remedy in capsules, with novelty, inventive step, descriptive sufficiency, industrial application and, consequently, covered with all essential requirements. for granting the privilege claimed.

Claims

REIVINDICAÇÕES
1. COMPOSIÇÃO PARA TRATAMENTO E DISSOLUÇÃO DE CÁLCULOS RENAIS caracterizada por compreender 25 - 40% de vinagre, 25 - 40% de mel e 25 - 40% de azeite. 1. COMPOSITION FOR TREATMENT AND DISSOLUTION OF KIDNEY CALCULATIONS characterized by comprising 25 - 40% vinegar, 25 - 40% honey and 25 - 40% olive oil.
2. COMPOSIÇÃO PARA TRATAMENTO E DISSOLUÇÃO DE 2. COMPOSITION FOR TREATMENT AND DISSOLUTION OF
CÁLCULOS RENAIS, de acordo com a reivindicação 1 , caracterizada pelo vinagre da composição ser o vinagre de maçã. KIDNEY CALCULATIONS according to claim 1, characterized in that the vinegar in the composition is apple cider vinegar.
3. COMPOSIÇÃO PARA TRATAMENTO E DISSOLUÇÃO DE 3. COMPOSITION FOR TREATMENT AND DISSOLUTION OF
CÁLCULOS RENAIS, de acordo com a reivindicação 1 , caracterizada pelo compreender 33,33% de vinagre de maçã, 33,33% de mel e 33,33% de azeite de oliva. KIDNEY CALCULATIONS according to claim 1, characterized by comprising 33.33% of apple cider vinegar, 33.33% of honey and 33.33% of olive oil.
4. COMPOSIÇÃO PARA TRATAMENTO E DISSOLUÇÃO DE 4. COMPOSITION FOR TREATMENT AND DISSOLUTION OF
CÁLCULOS RENAIS, de acordo com qualquer uma das reivindicações 1 a 4, caracterizada pelo azeite compreendido na composição ser o azeite de oliva extravirgem. KIDNEY CALCULATIONS according to any one of claims 1 to 4, characterized in that the oil comprised in the composition is extra virgin olive oil.
5. COMPOSIÇÃO PARA TRATAMENTO E DISSOLUÇÃO DE 5. COMPOSITION FOR TREATMENT AND DISSOLUTION OF
CÁLCULOS RENAIS, de acordo com a reivindicação 1 , caracterizada por a dita composição ser armazenada em cápsulas de gel. KIDNEY CALCULATIONS according to claim 1, characterized in that said composition is stored in gel capsules.
6. USO DA COMPOSIÇÃO, conforme descrita na reivindicação 1 , caracterizado por ser para o preparo de um medicamento para tratamento de cálculo renal.  6. USE OF THE COMPOSITION, as described in claim 1, characterized by being for the preparation of a drug for the treatment of kidney stones.
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