WO2020086046A3 - Compositions topiques comprenant une combinaison de tolpérisone et de flurbiprofène - Google Patents

Compositions topiques comprenant une combinaison de tolpérisone et de flurbiprofène Download PDF

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Publication number
WO2020086046A3
WO2020086046A3 PCT/TR2019/050902 TR2019050902W WO2020086046A3 WO 2020086046 A3 WO2020086046 A3 WO 2020086046A3 TR 2019050902 W TR2019050902 W TR 2019050902W WO 2020086046 A3 WO2020086046 A3 WO 2020086046A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolperisone
topical compositions
flurbiprofen
combination
pharmaceutically acceptable
Prior art date
Application number
PCT/TR2019/050902
Other languages
English (en)
Other versions
WO2020086046A2 (fr
Inventor
Emine TUNCAY
Melda MISIRLI
Seyhan TURKKAN
Nur PEHLIVAN AKALIN
Ali Turkyilmaz
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi filed Critical Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Publication of WO2020086046A2 publication Critical patent/WO2020086046A2/fr
Publication of WO2020086046A3 publication Critical patent/WO2020086046A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions topiques pharmaceutiques comprenant de la tolpérisone ou un sel, un solvate, un polymorphe, un isomère, un énantiomère ou un mélange racémique pharmaceutiquement acceptable de celle-ci, ainsi qu'un anti-inflammatoire non stéroïdien ou des sels, des solvates, des polymorphes, des isomères, des énantiomères ou des mélanges racémiques pharmaceutiquement acceptables de celui-ci.
PCT/TR2019/050902 2018-10-26 2019-10-25 Compositions topiques comprenant une combinaison de tolpérisone et de flurbiprofène WO2020086046A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2018/16046 2018-10-26
TR201816046 2018-10-26

Publications (2)

Publication Number Publication Date
WO2020086046A2 WO2020086046A2 (fr) 2020-04-30
WO2020086046A3 true WO2020086046A3 (fr) 2020-07-09

Family

ID=70332056

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2019/050902 WO2020086046A2 (fr) 2018-10-26 2019-10-25 Compositions topiques comprenant une combinaison de tolpérisone et de flurbiprofène

Country Status (1)

Country Link
WO (1) WO2020086046A2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0454089A1 (fr) * 1990-04-27 1991-10-30 Sekisui Kagaku Kogyo Kabushiki Kaisha Préparation d'épérisone ou de tolpérisone absorbable par voie percutanée
JP2000143510A (ja) * 1998-11-16 2000-05-23 Taisho Pharmaceut Co Ltd 外用組成物
WO2009081217A1 (fr) * 2007-12-20 2009-07-02 Richter Gedeon Nyrt. Formulations pharmaceutiques contenant tolperisone
EP2128123A1 (fr) * 2007-01-29 2009-12-02 Medrx Co., Ltd. Sel d'anti-inflammatoire non steroidien et de compose amine organique et leur utilisation
EP2486915A1 (fr) * 2011-02-14 2012-08-15 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Compositions pharmaceutiques topiques contenant flurbiprofène et méthylsulfonylméthane

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0454089A1 (fr) * 1990-04-27 1991-10-30 Sekisui Kagaku Kogyo Kabushiki Kaisha Préparation d'épérisone ou de tolpérisone absorbable par voie percutanée
JP2000143510A (ja) * 1998-11-16 2000-05-23 Taisho Pharmaceut Co Ltd 外用組成物
EP2128123A1 (fr) * 2007-01-29 2009-12-02 Medrx Co., Ltd. Sel d'anti-inflammatoire non steroidien et de compose amine organique et leur utilisation
WO2009081217A1 (fr) * 2007-12-20 2009-07-02 Richter Gedeon Nyrt. Formulations pharmaceutiques contenant tolperisone
EP2486915A1 (fr) * 2011-02-14 2012-08-15 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Compositions pharmaceutiques topiques contenant flurbiprofène et méthylsulfonylméthane

Also Published As

Publication number Publication date
WO2020086046A2 (fr) 2020-04-30

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