WO2019190432A3 - Combinaisons de tolpérisone et d'inhibiteur de la cox non sélectif - Google Patents

Combinaisons de tolpérisone et d'inhibiteur de la cox non sélectif Download PDF

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Publication number
WO2019190432A3
WO2019190432A3 PCT/TR2018/050801 TR2018050801W WO2019190432A3 WO 2019190432 A3 WO2019190432 A3 WO 2019190432A3 TR 2018050801 W TR2018050801 W TR 2018050801W WO 2019190432 A3 WO2019190432 A3 WO 2019190432A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolperisone
selective cox
cox inhibitor
inhibitor combinations
pharmaceutically acceptable
Prior art date
Application number
PCT/TR2018/050801
Other languages
English (en)
Other versions
WO2019190432A2 (fr
Inventor
Ali TÜRKYILMAZ
Nur PEHLIVAN AKALIN
Seyhan TÜRKKAN
Melda MISIRLI
Emine TUNCAY
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi filed Critical Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority to EP18911384.8A priority Critical patent/EP3723735A4/fr
Publication of WO2019190432A2 publication Critical patent/WO2019190432A2/fr
Publication of WO2019190432A3 publication Critical patent/WO2019190432A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des combinaisons pharmaceutiques comprenant de la tolpérisone ou un solvate, un polymorphe, un isomère, un énantiomère, un mélange racémique ou un sel pharmaceutiquement acceptable de celle-ci, et des inhibiteurs de la COX non sélectifs ou des solvates, des polymorphes, des isomères, des énantiomères, des sels ou des mélanges racémiques pharmaceutiquement acceptables de ceux-ci.
PCT/TR2018/050801 2017-12-13 2018-12-12 Combinaisons de tolpérisone et d'inhibiteur de la cox non sélectif WO2019190432A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18911384.8A EP3723735A4 (fr) 2017-12-13 2018-12-12 Combinaisons de tolpérisone et d'inhibiteur de la cox non sélectif

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2017/20293A TR201720293A2 (tr) 2017-12-13 2017-12-13 Tolperi̇zon ve non-selekti̇f cox i̇nhi̇bi̇törü kombi̇nasyonlari
TR2017/20293 2017-12-13

Publications (2)

Publication Number Publication Date
WO2019190432A2 WO2019190432A2 (fr) 2019-10-03
WO2019190432A3 true WO2019190432A3 (fr) 2019-11-21

Family

ID=67952207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2018/050801 WO2019190432A2 (fr) 2017-12-13 2018-12-12 Combinaisons de tolpérisone et d'inhibiteur de la cox non sélectif

Country Status (3)

Country Link
EP (1) EP3723735A4 (fr)
TR (1) TR201720293A2 (fr)
WO (1) WO2019190432A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1362585A2 (fr) * 2001-01-26 2003-11-19 Osmotica Corp. Compositions pharmaceutiques contenant un inhibiteur de cox-ii et un relaxant musculaire
WO2009081217A1 (fr) * 2007-12-20 2009-07-02 Richter Gedeon Nyrt. Formulations pharmaceutiques contenant tolperisone
WO2010103544A2 (fr) * 2009-03-09 2010-09-16 Dinesh Shantilal Patel Nouvelle composition à libération prolongée de composés choisis dans la classe des relaxants musculaires à action centrale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1362585A2 (fr) * 2001-01-26 2003-11-19 Osmotica Corp. Compositions pharmaceutiques contenant un inhibiteur de cox-ii et un relaxant musculaire
WO2009081217A1 (fr) * 2007-12-20 2009-07-02 Richter Gedeon Nyrt. Formulations pharmaceutiques contenant tolperisone
WO2010103544A2 (fr) * 2009-03-09 2010-09-16 Dinesh Shantilal Patel Nouvelle composition à libération prolongée de composés choisis dans la classe des relaxants musculaires à action centrale

Also Published As

Publication number Publication date
EP3723735A4 (fr) 2021-11-10
WO2019190432A2 (fr) 2019-10-03
EP3723735A2 (fr) 2020-10-21
TR201720293A2 (tr) 2019-06-21

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