WO2020080978A3 - Method for producing a blood substitute for use in veterinary medicine - Google Patents

Method for producing a blood substitute for use in veterinary medicine Download PDF

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Publication number
WO2020080978A3
WO2020080978A3 PCT/RU2019/050191 RU2019050191W WO2020080978A3 WO 2020080978 A3 WO2020080978 A3 WO 2020080978A3 RU 2019050191 W RU2019050191 W RU 2019050191W WO 2020080978 A3 WO2020080978 A3 WO 2020080978A3
Authority
WO
WIPO (PCT)
Prior art keywords
haemoglobin
polymerized
producing
mass
veterinary medicine
Prior art date
Application number
PCT/RU2019/050191
Other languages
French (fr)
Russian (ru)
Other versions
WO2020080978A2 (en
Inventor
Рахимджан Ахметджанович РОЗИЕВ
Владимир Александрович ХАРЛАМОВ
Ольга Борисовна Брускова
Ирина Григорьевна КОНДРАШЕВА
Елена Евгеньевна КАЛАШНИКОВА
Екатерина Валерьевна БОНДАРЕНКО
Кенес Тагаевич ЕРИМБЕТОВ
Анна Яковлевна ГОНЧАРОВА
Original Assignee
Рахимджан Ахметджанович РОЗИЕВ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2018136935A external-priority patent/RU2782076C2/en
Application filed by Рахимджан Ахметджанович РОЗИЕВ filed Critical Рахимджан Ахметджанович РОЗИЕВ
Publication of WO2020080978A2 publication Critical patent/WO2020080978A2/en
Publication of WO2020080978A3 publication Critical patent/WO2020080978A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins

Abstract

What is proposed is: a method for producing a blood substitute from polymerized haemoglobin, a base of blood-substituting solutions with the function of transporting oxygen for use in veterinary medicine, the method comprising producing deoxygenated livestock haemoglobin, and polymerizing and cleaning same. In order to produce deoxygenated haemoglobin, an erythrocyte mass free from leucocytes is separated off by means of plasmapheresis, non-heme proteins are precipitated by adding dry sodium chloride to the haemoglobin solution in a concentration of 0.6 % by mass, a diafiltration step for cleaning the polymerized haemoglobin is carried out in a single stage on detaching membranes on the basis of a molecular mass of 100 kDa, and a finished product with a content of polymerized haemoglobin with a molecular mass of greater than 64 kDa within the range of from 75% to 95% is produced. The technical result consists in shortening the time for filtration of the polymerized haemoglobin, reducing the volume of washing solution and reducing the pyrogenicity of the finished product.
PCT/RU2019/050191 2018-10-19 2019-10-21 Method for producing a blood substitute for use in veterinary medicine WO2020080978A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2018136935 2018-10-19
RU2018136935A RU2782076C2 (en) 2018-10-19 Method for production of blood substitute for use in veterinary medicine

Publications (2)

Publication Number Publication Date
WO2020080978A2 WO2020080978A2 (en) 2020-04-23
WO2020080978A3 true WO2020080978A3 (en) 2020-06-18

Family

ID=70277569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2019/050191 WO2020080978A2 (en) 2018-10-19 2019-10-21 Method for producing a blood substitute for use in veterinary medicine

Country Status (1)

Country Link
WO (1) WO2020080978A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
EP0361720A1 (en) * 1988-09-08 1990-04-04 Technion Research & Development Foundation Ltd. Hemoglobin-based blood substitute and method for the preparation thereof
RU2341286C1 (en) * 2007-07-25 2008-12-20 Общество с ограниченной ответственностью "Геленпол" Method of blood substitute production and related installation for method implementation
RU2361608C1 (en) * 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Blood substitute with function of oxygen transfer, pharmaceutical composition (versions)
RU2475252C1 (en) * 2010-05-27 2013-02-20 Бин Лоу Вон Method for preparing high-temperature stable pharmaceutical composition containing oxygen carrier and using it

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
EP0361720A1 (en) * 1988-09-08 1990-04-04 Technion Research & Development Foundation Ltd. Hemoglobin-based blood substitute and method for the preparation thereof
RU2341286C1 (en) * 2007-07-25 2008-12-20 Общество с ограниченной ответственностью "Геленпол" Method of blood substitute production and related installation for method implementation
RU2361608C1 (en) * 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Blood substitute with function of oxygen transfer, pharmaceutical composition (versions)
RU2475252C1 (en) * 2010-05-27 2013-02-20 Бин Лоу Вон Method for preparing high-temperature stable pharmaceutical composition containing oxygen carrier and using it

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHEVCHENKO NIKOLAI VASILEVICH ET AL.: "Kharakteristika perenoschikov kisloroda v sovremennykh zameniteliakh krovi", KAZANSKII MEDITSINSKII ZHURNAL, 2012, pages 398 - 400, XP055717507 *

Also Published As

Publication number Publication date
WO2020080978A2 (en) 2020-04-23
RU2018136935A (en) 2020-04-20
RU2018136935A3 (en) 2022-04-25

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