Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
  • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
  • C07F9/02—Phosphorus compounds
  • C07F9/28—Phosphorus compounds with one or more P—C bonds
  • C07F9/50—Organo-phosphines
  • C07F9/505—Preparation; Separation; Purification; Stabilisation
• • C—CHEMISTRY; METALLURGY
  • C01—INORGANIC CHEMISTRY
  • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
  • C01B6/00—Hydrides of metals including fully or partially hydrided metals, alloys or intermetallic compounds ; Compounds containing at least one metal-hydrogen bond, e.g. (GeH3)2S, SiH GeH; Monoborane or diborane; Addition complexes thereof
  • C01B6/06—Hydrides of aluminium, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth or polonium; Monoborane; Diborane; Addition complexes thereof
  • C01B6/10—Monoborane; Diborane; Addition complexes thereof
  • C01B6/13—Addition complexes of monoborane or diborane, e.g. with phosphine, arsine or hydrazine
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
  • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
  • C07F9/02—Phosphorus compounds
  • C07F9/28—Phosphorus compounds with one or more P—C bonds
  • C07F9/50—Organo-phosphines
  • C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals

Definitions

• the present specification generally relates to methods for preparing borane complexes from aryldihalophosphines.
• the present specification is directed to methods for preparing borane complexes from aryldihalophosphines with a solution comprising sodium borohydride.
• Arylphosphines have potential uses as raw materials to commercial ligands in transition metal catalysis.
• phosphines are prone to oxidation and/or combustion, which make them dangerous to transport and handle.
• intermediary complexes of arylphosphines are formed that are less dangerous to transport and handle.
• the intermediary complexes can either be used in place of arylphosphines, or the intermediary complexes can be converted back to arylphosphines when they have safely been transported and/or handled.
• Intermediary complexes of arylphosphines that have been particularly useful are borane complexes of arylphosphines.
• methods for preparing phosphine-borane complexes from aryldihalophosphine comprise: mixing sodium borohydride (NaBH 4 ), a solvent comprising at least 50 volume percent (vol%) glycol ethers, and the aryldihalophosphine to obtain a solution; and maintaining the solution at a reaction temperature for a duration of time to obtain the phosphine-borane complexes.
• the glycol ethers comprises l,2-dimethoxyethane
• the solvent further comprises tetrahydrofuran.
• a ratio of tetrahydrofuran to l,2-dimethoxyethane in the solvent comprising may be from 0.1: 1.0 to 2.5: 1.0. In some embodiments, a ratio of sodium borohydride to aryldihalophosphine is from 1.1:1.0 to 2.5:l.O.
• FIG. 1 is a 1H NMR spectrum and peak assignments for a 2,4- dimethoxyphenylphosphine-borane complex according to embodiments disclosed and described herein;
• FIG. 2 is a 13 C NMR spectrum and peak assignments for a 2,4- dimethoxyphenylphosphine-borane complex according to embodiments disclosed and described herein;
• FIG. 3 is a 31 P NMR spectrum for 2,4-dimethoxyphenylphosphine-borane complex (upper spectrum), 2,4-dimethoxyphenyl-P,P-dichlorophosphine (lower spectrum), and 2,4- dimethoxyphenylpho spine (inset) according to embodiments disclosed and described herein; and
• FIG. 4 is a 31 P NMR spectrum for phenylphosphine-borane complex according to the embodiments disclosed and described herein.
• BH THF borane tetrahydrofuran complex
• BH 3 -SMe 2 borane dimethyl sulfide
• NaBH 4 sodium borohydride
• DME l,2-dimethoxyethane
• THF tetrahydrofuran
• CDC1 3 deuterated chloroform
• ZnCl 2 zinc chloride
• s seconds
• ppm parts per million
• Hz hertz
• psec microseconds
• mm millimeter
• g gram
• mmol millimolar
• mL milliliter.
• Aryl phosphine borane complexes are generally prepared in two steps: (1) reduction of an aryldichlorophosphine to a phosphine; and (2) subsequent reaction with a borane source such as borane tetrahydrofuran complex (BH 3 THF) or borane dimethyl sulfide (BH 3 SMe 2 ).
• a borane source such as borane tetrahydrofuran complex (BH 3 THF) or borane dimethyl sulfide (BH 3 SMe 2 ).
• BH 3 THF borane tetrahydrofuran complex
• BH 3 SMe 2 borane dimethyl sulfide
• Another preparation route that has been considered and is used to form borane complexes with some phosphines include using sodium borohydride (NaBH 4 ).
• methods for preparing phosphine-borane complexes from aryldihalophosphine comprise: mixing sodium borohydride (NaBH 4 ), a solvent comprising at least 50 vol% glycol ethers, and the aryldihalophosphine to obtain a solution; and maintaining the solution at a reaction temperature for a duration of time to obtain the phosphine-borane complexes.
• NaBH 4 sodium borohydride
• solvent comprising at least 50 vol% glycol ethers
• methods for preparing phosphine-borane complexes from aryldihalophosphine comprises mixing NaBH 4 and the aryldihalophosphine in a solvent comprising 50 vol% glycol ethers.
• the NaBH 4 used in methods for preparing phosphine-borane complexes is not limited and can be commercially available NaBH 4 .
• the NaBH 4 is powdered NaBH 4 with a purity greater than 98%, such as greater than 99%.
• the aryldihalophosphine that is mixed with NaBH 4 to form an arylphosphine-borane complex may be, in embodiments, an aryldichlorophosphine, such as, for example, an aryldichlorophosphine selected from the group consisting of dichloro(2,4- dimethoxyphenyl)phosphine, dichloro(2-methoxyphenyl)phosphine, and dichlorophenylphosphine.
• the aryldihalophosphine may be a mono-aryldihalophosphine, such as, for example, mono-aryldichlorophosphine.
• THF is a solvent that is commonly used to form phosphine- borane complexes.
• THF is used as the sole solvent for preparing phosphine- borane complexes.
• a solvent comprising THF alone will not produce a phosphine-borane complex with NaBH 4 and aryldihalophosphine, such as, for example, aryldichlorophosphine. The solution to this issue is not readily ascertainable.
• Lam, Hubert et al., Mild Reduction of Chlorophosphine Boranes to Secondary Phosphine Boranes, 44 Tetrahedron Letters, 5213-5216 (2003) discloses that a preformed chlorophosphine-borane complex, generated by mixing the chloropho spine and BH 3» THF, produced a phosphine-borane complex by mixing NaBH 4 and diary lmonohalophosphine-borane complex in a solvent that only comprises THF ( i.e solvent is 100 vol% THF).
• NaBH 4 and aryldihalophosphine will not form a phosphine-borane complex in a solvent that only comprises THF.
• a phosphine-borane complex is prepared by mixing NaBH 4 and aryldihalophosphine in a solvent.
• a desired phosphine-borane complex may be formed by mixing NaBH 4 and aryldihalophosphine at an appropriate ratio.
• a ratio of NaBH 4 to aryldichlorophosphine is from 1.1: 1.0 to 2.5: 1.0, such as from 1.2: 1.0 to 2.5: 1.0, from 1.3: 1.0 to 2.5: 1.0, from 1.4: 1.0 to 2.5: 1.0, from 1.5: 1.0 to 2.5: 1.0, from 1.6: 1.0 to 2.5: 1.0, from 1.7: 1.0 to 2.5:1.0, from 1.8:1.0 to 2.5:1.0, from 1.9:1.0 to 2.5:1.0, from 2.0:1.0 to 2.5:1.0, from 2.1:1.0 to 2.5: 1.0, from 2.2: 1.0 to 2.5: 1.0, from 2.3: 1.0 to 2.5: 1.0, or from 2.4: 1.0 to 2.5: 1.0.
• a ratio of NaBH 4 to aryldichlorophosphine is from 1.1: 1.0 to 2.4: 1.0, such as from 1.1:1.0 to 2.3:1.0, from 1.1:1.0 to 2.2:1.0, from 1.1:1.0 to 2.1:1.0, from 1.1:1.0 to 2.0:1.0, from 1.1:1.0 to 1.9:1.0, from 1.1:1.0 to 1.8:1.0, from 1.1:1.0 to 1.7:1.0, from 1.1:1.0 to 1.6:1.0, from 1.1:1.0 to 1.5:1.0, from 1.1:1.0 to 1.4:1.0, from 1.1:1.0 to 1.3:1.0, or from 1.1:1.0 to 1.2:1.0.
• a ratio of NaBH 4 to aryldichlorophosphine is from 1.2: 1.0 to 2.4: 1.0, such as from 1.3: 1.0 to 2.3: 1.0, from 1.4: 1.0 to 2.2: 1.0, from 1.5: 1.0 to 2.1:1.0, from 1.6: 1.0 to 2.0: 1.0, or from 1.7: 1.0 to 1.9: 1.0.
• a ratio of NaBH 4 to aryldichlorophosphine is from 1.5:1.0 to 2.2:1.0, such as from 1.6:1.0 to 2.1:1.0, from 1.7:1.0 to 2.0:1.0, or from 1.8:1.0 to 1.9:1.0.
• Methods for preparing phosphine-borane complexes from aryldihalophosphine comprises mixing NaBH 4 and aryldihalophosphine in a solvent comprising at least 50 vol% glycol ethers, such as at least 55 vol% glycol ethers, at least 60 vol% glycol ethers, at least 65 vol% glycol ethers, at least 70 vol% glycol ethers, at least 75 vol% glycol ethers, at least 80 vol% glycol ethers, at least 85 vol% glycol ethers, at least 90 vol% glycol ethers, or at least 95 vol% glycol ethers.
• a solvent comprising at least 50 vol% glycol ethers, such as at least 55 vol% glycol ethers, at least 60 vol% glycol ethers, at least 65 vol% glycol ethers, at least 70 vol% glycol ethers, at least 75 vol% glycol ethers, at least 80 vol% glycol ethers, at least 85
• the glycol ethers in the solvent may comprise 1,2- dimethoxyethane (DME), triglyme, diglyme, or mixtures thereof.
• the glycol ethers in the solvent comprise DME.
• the solvent in which NaBH 4 and aryldihalophosphine is mixed may comprise at least 50 vol% DME, such as at least 55 vol% DME, at least 60 vol% DME, at least 65 vol% DME, at least 70 vol% DME, at least 75 vol% DME, at least 80 vol% DME, at least 85 vol% DME, at least 90 vol% DME, or at least 95 vol% DME.
• the solvent in which NaBH 4 and aryldihalophosphine are mixed may, in embodiments, comprise components other than glycol ethers. According to some embodiments, the solvent in which NaBH 4 and aryldihalophosphine are mixed may comprise tetrahydrofuran (THF), toluene, or mixtures thereof.
• THF tetrahydrofuran
• the solvent may comprise from 5 vol% to 50 vol% THF, such as from 10 vol% to 50 vol% THF, from 15 vol% to 50 vol% THF, from 20 vol% to 50 vol% THF, from 25 vol% to 50 vol% THF, from 30 vol% to 50 vol% THF, from 35 vol% to 50 vol% THF, from 40 vol% to 50 vol% THF, or from 45 vol% to 50 vol% THF.
• THF such as from 10 vol% to 50 vol% THF, from 15 vol% to 50 vol% THF, from 20 vol% to 50 vol% THF, from 25 vol% to 50 vol% THF, from 30 vol% to 50 vol% THF, from 35 vol% to 50 vol% THF, from 40 vol% to 50 vol% THF, or from 45 vol% to 50 vol% THF.
• the solvent may comprise from 5 vol% to 45 vol% THF, such as from 5 vol% to 40 vol% THF, from 5 vol% to 35 vol% THF, from 5 vol% to 30 vol% THF, from 5 vol% to 25 vol% THF, from 5 vol% to 20 vol% THF, from 5 vol% to 15 vol% THF, or from 5 vol% to 10 vol% THF.
• the solvent may comprise from 10 vol% to 45 vol% THF, such as from 15 vol% to 40 vol% THF, from 20 vol% to 35 vol% THF, or from 25 vol% to 30 vol% THF.
• the solvent in which NaBH 4 and aryldihalophosphine are mixed may comprise a mixture of DME and THF.
• the solvent in which NaBH 4 and aryldihalophosphine is mixed comprises a ratio of THF to DME from 0.1: 1.0 to 2.5: 1.0, such as from 0.2: 1.0 to 2.5: 1.0, from 0.3: 1.0 to 2.5: 1.0, from 0.4: 1.0 to 2.5: 1.0, from 0.5:1.0 to 2.5:1.0, from 0.6:1.0 to 2.5:1.0, from 0.7:1.0 to 2.5:1.0, from 0.8:1.0 to 2.5:1.0, from
• the solvent in which NaBH 4 and aryldihalophosphine is mixed comprises a ratio of THF to DME from 0.1: 1.0 to 2.4: 1.0, such as from 0.1: 1.0 to 2.3: 1.0, from 0.1: 1.0 to 2.2: 1.0, from 0.1: 1.0 to 2.2: 1.0, from 0.1: 1.0 to 2.1:1.0, from 0.1: 1.0 to 2.0: 1.0, from 0.1: 1.0 to
• the solvent in which NaBH 4 and aryldihalophosphine is mixed comprises a ratio of THF to DME from 0.2: 1.0 to 2.4: 1.0, such as from 0.3: 1.0 to 2.3: 1.0, from 0.4: 1.0 to 2.2: 1.0, from 0.5: 1.0 to 2.1:1.0, from 0.6: 1.0 to
• the solvent in which NaBH 4 and aryldihalophosphine is mixed comprises a ratio of THF to DME from 0.1: 1.0 to 1.0:1.0, such as from 0.2:1.0 to 0.9:1.0, from 0.3:1.0 to 0.8:1.0, from 0.4:l.0 to 0.7:1.0, or from 0.5:1.0 to 0.7:1.0.
• NaBH 4 and aryldihalophosphine may be mixed by adding each as a dry component to a solvent that comprises at least 50 vol% glycol ethers.
• NaBH 4 may be added to a first solvent to form a first suspension
• aryldihalophosphine may be added to a second solvent to form a second suspension.
• the first suspension and the second suspension are combined, which results in mixing the NaBH 4 and aryldihalophosphine.
• the first solvent and the second solvent may be the same or different.
• each of the first solvent and the second solvent may comprise at least 50 vol% glycol ethers so that when the first suspension and the second suspension are combined, the combined solvent comprises at least 50 vol% glycol ethers.
• the composition of the first solvent and the composition of the second solvent should be formulated such that when the first suspension and the second suspension are combined, the combined solvent comprises at least 50 vol% glycol ethers. It should be understood that a skilled artisan is capable of formulating the first solvent and the second solvent so that when the first suspension and the second suspension are combined, the combined solvent comprises at least 50 vol% glycol ethers.
• At least one of the first solvent and/or the second solvent comprises at least 50 vol% glycol ethers.
• at least one of the first solvent and/or the second solvent may comprise THF.
• the first solvent and the second solvent may be formulated to yield the THF to DME ratios disclosed herein.
• embodiments of methods for preparing phosphine borane complexes disclosed and described herein comprise mixing NaBH 4 and aryldihalophosphine in a solvent comprising at least 50 vol% glycol ethers to obtain a solution, and maintaining the solution at a reaction temperature.
• the reaction temperature may be from 0 °C to 60 °C, such as from 5 °C to 60 °C, from 10 °C to 60 °C, from 15 °C to 60 °C, from 20 °C to 60 °C, from 25 °C to 60 °C, from 30 °C to 60 °C, from 35 °C to 60 °C, from 40 °C to 60 °C, from 45 °C to 60 °C, from 50 °C to 60 °C, or from 55 °C to 60 °C.
• the reaction temperature may be from 0 °C to 55 °C, such as from 0 °C to 50 °C, from 0 °C to 45 °C, from 0 °C to 40 °C, from 0 °C to 35 °C, from 0 °C to 30 °C, from 0 °C to 25 °C, from 0 °C to 20 °C, from 0 °C to 15 °C, from 0 °C to 10 °C, or from 0 °C to 5 °C.
• the reaction temperature may be from 5 °C to 55 °C, such as from 10 °C to 50 °C, from 15 °C to 45 °C, from 20 °C to 40 °C, or from 20 °C to 35 °C.
• the solvent may be adjusted to the reaction temperature before NaBH 4 and/or aryldihalophosphine is added to the solvent.
• NaBH 4 and/or aryldihalophosphine may be added to the solvent at ambient temperature and the mixture of NaBH 4 , aryldihalophosphine, and solvent are adjusted to the reaction temperature.
• NaBH 4 is added to a first solvent to form a first suspension and aryldihalophosphine is added to a second solvent to form a second suspension
• the first solvent and/or the second solvent may be adjusted to the reaction temperature before the NaBH 4 and/or aryldihalophosphine is added to the first solvent and/or second solvent, respectively.
• NaBH 4 is added to a first solvent at ambient temperature to form a first suspension and/or aryldihalophosphine is added to a second solvent at ambient temperature to form a second suspension, and the first suspension and/or the second suspension may be adjusted to the reaction temperature after the NaBH 4 and/or aryldihalophosphine is added to the first solvent and/or second solvent, respectively.
• NaBH 4 is added to a first solvent at ambient temperature to form a first suspension and/or aryldihalophosphine is added to a second solvent at ambient temperature to form a second suspension, the first suspension and the second suspension may be combined at ambient temperature to form a combined solution, and the combined solution may be adjusted to the reaction temperature.
• the temperature of any of the solvents or suspensions disclosed herein may be adjusted to the reaction temperature by any suitable mechanism for adjusting the temperature of solutions or suspensions.
• the solution comprising NaBH 4 , aryldihalophosphine, and a solvent comprising at least 50 vol% glycol ethers is maintained at the reaction temperature for a duration of time.
• the duration of time is from 0.05 hours to 12.00 hours, such as from 0.10 hours to 12.00 hours, from 0.50 hours to 12.00 hours, from 1.00 hours to 12.00 hours, from 1.50 hours to 12.00 hours, from 2.00 hours to 12.00 hours, from 2.50 hours to 12.00 hours, from 3.00 hours to 12.00 hours, from 3.50 hours to 12.00 hours, from 4.00 hours to 12.00 hours, from 4.50 hours to 12.00 hours, from 5.00 hours to 12.00 hours, from 5.50 hours to 12.00 hours, from 6.00 hours to 12.00 hours, from 6.50 hours to 12.00 hours, from 6.50 hours to 12.00 hours, from 7.00 hours to 12.00 hours, from 7.50 hours to 12.00 hours, from 8.00 hours to 12.00 hours, from 8.50 hours to 12.00 hours, from 9.00 hours to 12.00 hours, from 9.50 hours to 12.00 hours, from 10.00 hours to 12.00 hours, from 10.50 hours to 12.00 hours, from 11.00 hours to 12.00 hours, or from 11.50 hours to 12.00 hours.
• the duration of time is from 0.05 hours to 11.50 hours, such as from 0.05 hours to 11.00 hours, from 0.05 hours to 10.50 hours, from 0.05 hours to 10.00 hours, from 0.05 hours to 9.50 hours, from 0.05 hours to 9.00 hours, from 0.05 hours to 8.50 hours, from 0.05 hours to 8.00 hours, from 0.05 hours to 7.50 hours, from 0.05 hours to 7.00 hours, from 0.05 hours to 6.50 hours, from 0.05 hours to 11.50 hours, such as from 0.05 hours to 11.00 hours, from 0.05 hours to 10.50 hours, from 0.05 hours to 10.00 hours, from 0.05 hours to 9.50 hours, from 0.05 hours to 9.00 hours, from 0.05 hours to 8.50 hours, from 0.05 hours to 8.00 hours, from 0.05 hours to 7.50 hours, from 0.05 hours to 7.00 hours, from 0.05 hours to 6.50 hours, from 0.05 hours to 11.50 hours, such as from 0.05 hours to 11.00 hours, from 0.05 hours to 10.50 hours, from 0.05 hours to 10.00 hours, from 0.05 hours to 9.50 hours,
• the duration of time is from 0.10 hours to 11.50 hours, such as from 0.50 hours to 11.00 hours, from 1.00 hours to 10.50 hours, from 1.50 hours to 10.00 hours, from 2.00 hours to 9.50 hours, from 2.50 hours to 9.00 hours, from 3.00 hours to 8.50 hours, from
• reaction time is from 0.10 hours to 2.00 hours, such as from 0.50 hours to 1.50 hours, or 1.00 hour.
• Methods for preparing phosphine-borane complexes from aryldihalophosphine comprise mixing NaBH 4 , a solvent comprising at least 50 vol% DME, and aryldichlorophosphine to obtain a solution; and maintaining the solution at a reaction temperature for a duration of time to obtain the phosphine-borane complexes.
• the aryldichlorophosphine is mono-aryldichlorophosphine.
• the solvent further comprises THF.
• Methods for preparing phosphine-borane complexes from aryldihalophosphine comprise obtaining a solution comprising NaBH 4 suspended in a solvent comprising at least 50 vol% DME; adjusting a temperature of the solution to a reaction temperature; obtaining a combined solution by combining the solution with a second solution, wherein the second solution comprises aryldichlorophosphine and a second solvent; and maintaining the combined solution at the reaction temperature for a duration of time to obtain the phosphine-borane complexes.
• the aryldichlorophosphine is mono- aryldichlorophosphine.
• the solvent further comprises THF.
• the second solvent may, in embodiments, comprise THF.
• the conversion of the aryldihalophosphine in a solution comprising NaBH 4 and at least 50 vol% glycol ethers to arylphosphine-borane complexes is at least 90%, such as at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%.
• the conversion of the aryldihalophosphine in a solution comprising NaBH 4 and at least 50 vol% glycol ethers to arylphosphine-borane complexes is 100%.
• the mixture was maintained at 2 °C for a duration of half an hour (0.50 hours).
• 20 ml hexane was added to the flask and more solid precipitated out.
• the white slurry was filtered and the solid was washed by an additional 20 ml of hexane.
• the filtrate turned hazy, which was then filtered again to remove the solid.
• the solvent was removed and led to a white solid, which was further dried in the vacuum oven at 40 °C.
• the yield of the 2,4-dimethoxyphenylphosphine)-borane complex was 1.62 g (82%).
• EXAMPLE 2 [0034] In a three-neck flask, 16 ml DME as was used in Example 1 was loaded and cooled to 0 °C and sparged with N 2 for 0.50 hours. Subsequently, 0.5 g of NaBH 4 solid was loaded into the flask. Then, 0.9 g (5 mmol) dichlorophenylphosphine as obtained from a commercial supplier was diluted in 4 ml N 2 sparged DME was slowly added to the flask at a temperature range from 1 °C to 7 °C. The mixture was maintained at 2 °C for one hour.
• THF to DME ratios of 3:1 and above do not provide an observable yield of 2, 4-dimethoxyphenylphosphine complex, but the yield of 2,4- dimethoxyphenylphosphine complex increases significantly from a THF to DME ratio of 3:1 to a THF to DME ratio of 1 : 1.
• NaBH 4 in an appropriate amount based on desired molar ratio to 2,4- (dimethoxyphenyl)dichlorophosphine (ArPCl 2 ) as shown in Table 3 below was added to a three- neck round bottom flask equipped with a condenser, thermometer and a septa. This flask was evacuated under vacuum and refilled with N 2 three times before DME (2.27 g) was added via syringe. 5.62 g of a 17.0 weight percent (wt%) ArPCl 2 stock solution (with ArPCl 2 0.962 g, 4.09 mmol) was added to the vial via syringe over a period of 0.5 hour and left stirring at room temperature overnight. Table 3 shows the results of this test.
• ArPCl 2 2,4- (dimethoxyphenyl)dichlorophosphine

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