WO2020040584A1 - Capteur moléculaire et système de diagnostic de cancer utilisant celui-ci - Google Patents

Capteur moléculaire et système de diagnostic de cancer utilisant celui-ci Download PDF

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WO2020040584A1
WO2020040584A1 PCT/KR2019/010737 KR2019010737W WO2020040584A1 WO 2020040584 A1 WO2020040584 A1 WO 2020040584A1 KR 2019010737 W KR2019010737 W KR 2019010737W WO 2020040584 A1 WO2020040584 A1 WO 2020040584A1
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Prior art keywords
anode
energy level
cathode
electrons
valence band
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PCT/KR2019/010737
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English (en)
Korean (ko)
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권민상
권위상
카사마야스히코
이명관
인기욱
박남현
강우신
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권민상
권위상
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Priority claimed from KR1020180117018A external-priority patent/KR20200037595A/ko
Application filed by 권민상, 권위상 filed Critical 권민상
Priority to CN201980060107.6A priority Critical patent/CN112689753A/zh
Priority claimed from KR1020190103415A external-priority patent/KR102231421B1/ko
Publication of WO2020040584A1 publication Critical patent/WO2020040584A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Definitions

  • the present invention relates to a molecular sensor that detects the presence, type, and amount of a substance to be detected in units of molecules, and in particular, is proportional to the number of molecules of the substance to be detected (hereinafter referred to as "detectable substance").
  • detecttable substance By designing the energy levels of the cathode and anode in consideration of the energy level of the redox potential of the target material so that a large number of electrons can move from the cathode to the anode, it is possible to precisely detect the target material on a molecular basis.
  • the method further includes a substance (hereinafter, referred to as a "mobile inducing substance”) that assists and induces electron movement from the cathode to the anode according to the type of the detection target material to be detected, and the electrons in the valence band are conducted as conduction bands.
  • a substance hereinafter, referred to as a "mobile inducing substance”
  • an excitation energy supply unit for supplying excitation energy to excite (excited atoms)
  • fullerene fullerene salt, or fullerene containing ions (hereinafter referred to as “ion-containing fullerene”) as a mobile inducer
  • ion-containing fullerene fullerene containing ions
  • the present invention is to use the molecular sensor described above to detect cancer, early detection of cancer, to prolong life and to pursue a healthy life.
  • ultra-precision sensors capable of detecting trace amounts of materials is continuously used, which is used in the fields of ultra-precision diagnostic medicine, ultra-precision sensing, ultra-precision control, and bio and space science.
  • cantilever type precision sensor for detecting a substance to be detected by detecting mechanical distortion caused by adsorption of the substance to be detected
  • a precision sensor using an asymmetric field ion transport analysis method that detects a substance to be detected by passing a substance to be detected inside a fluctuating electric field so that only molecules having a specific mass area ratio reach the detector;
  • An accurate sensor using a gene sensing method that detects a substance to be detected using a genetically modified mouse receptor is an example of such an ultra precision sensor.
  • An object of the present invention is to solve the conventional problems as described above, in particular, by using the energy level of the redox potential to detect the target material in molecular units of a new concept that can accurately detect the ppt level To provide a "molecular sensor".
  • the detection target material is detected by using a mobile induction material (anode-side movement induction material, cathode-side movement induction material) having energy levels of various redox potentials, thereby widening the detection object and making more accurate detection.
  • a mobile induction material anode-side movement induction material, cathode-side movement induction material
  • the present invention is a molecular sensor capable of precisely detecting a target substance on a molecular basis by using the energy level of the redox potential, in particular, by analyzing the energy level of the redox potential of the substance to be detected,
  • the energy levels of the negative electrode material and the positive electrode material are designed and configured such that electrons are transferred from the negative electrode to the positive electrode through the electrons donated by the detection target material.
  • the energy level is designed using one or more moving inducing materials that induce electron transfer from the cathode to the anode, and the lumo of the conduction band in the Highest Occupied Molecular Orbital (HOMO).
  • HOMO Highest Occupied Molecular Orbital
  • LMO Lowest Unoccupied Molecular Orbital
  • excitation energy light energy, heat energy, etc.
  • the mobile inducer is characterized by extending the detection range and improving the measurement sensitivity by constituting the mobile inducer with at least one of fullerene, fullerene salt, ion-containing fullerene, pigment, or complex of ion-containing fullerene and pigment.
  • the fullerene is any one of C60, C70, C72, C78, C82, C90, C94, C96, and the ions contained in the iontofullerene are lithium, sodium, potassium, cesium, magnesium, calcium, Or strontium, and the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT , P3OT, POPT, MDMO-PPV, MEH-PPV and the like, characterized in that at least one of a polymer or a derivative thereof.
  • P3HT poly-3-hexyl thiophene
  • P3HT poly p-phenylene
  • poly p-phenylene vinylene polyaniline
  • polypyrrole PEDOT , P3OT, POPT
  • MDMO-PPV MDMO-PPV
  • MEH-PPV MEH-PPV and the like
  • the "molecular sensor" of the present invention has the effect of accurately detecting the molecular units at the ppt level by detecting the detection target substance using the energy level of the redox potential.
  • the energy level using a mobile induction material, it is effective to widen the detection range, increase selectivity, and increase accuracy.
  • the energy level of the redox potential is very low and the quantum yield is high by using ion-containing fullerenes and pigments to design the energy level, thereby further extending the detection range and accuracy.
  • the present invention provides a ppt level of precision detection technology to solve the detection problems that could not be solved by the existing technologies in the field of ultra-precision diagnostic medicine, ultra-precision sensing, ultra-precision control and bio, aerospace sciences to make a leap forward in the field. It is effective to tow.
  • it can be configured to detect early cancers (substances caused by cancer) present in trace amounts in the breath, urine, blood and saliva, and to diagnose early cancer, Can be configured to detect tuberculosis early, to detect the bad breath (materials caused by bad breath) to determine the cause of bad breath, stress caused substances It is effective in detecting the stress level by detecting (substances caused by stress).
  • it can be configured to detect a small amount of deadly poison gas such as sarin gas, dioxin and the like to pre-alarm, as well as to configure a variety of precision sensors in various fields.
  • 3 is a view showing another energy level design of the "molecular sensor" of the present invention.
  • FIG. 6 is a view showing another energy level design of the "molecular sensor" of the present invention.
  • FIG. 10 is a view showing another energy level design of the "molecular sensor" of the present invention.
  • 13 is a view showing another energy level design of the "molecular sensor" of the present invention.
  • 15 is a block diagram showing a system configuration of the present invention.
  • 16 is a view showing the configuration of the sensor electrode unit of the present invention.
  • 17 is a view showing an energy level design according to an embodiment of the present invention.
  • FIG. 18 is a view showing a configuration of a sensor electrode unit according to an embodiment of the present invention.
  • FIG. 19 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention.
  • FIG. 20 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention.
  • 21A is a conceptual diagram showing an ion containing fullerene
  • Fig. 21B is a conceptual diagram showing the structure of a polymer in which an iontophorfullerene and a dye are bonded;
  • 21C is a conceptual diagram showing an excited state of electrons by light energy
  • 22 is a conceptual diagram showing the electrophoresis of fullerene-pigment polymer on the positive electrode
  • Fig. 23 shows the energy level of electrons.
  • 24 is a diagram conceptually showing a circuit configuration of a potentiostat
  • 25 is a diagram showing an example of a configuration of a measuring electrode
  • 26 is a graph illustrating interval enlargement of a CV graph
  • 27 is a graph showing an example of quantum yield according to wavelength.
  • 29 and 28 are views for explaining a second embodiment of the present invention.
  • 33 to 38 are views for explaining a fourth embodiment of the present invention.
  • 39 and 40 are views for explaining a fifth embodiment of the present invention.
  • 41 to 45 are views for explaining a sixth embodiment of the present invention.
  • 47 and 48 are views for explaining an eighth embodiment of the present invention.
  • 49 is a view for explaining a ninth embodiment of the present invention.
  • the first embodiment of the present invention relates to a molecular sensor and can detect cancer or other molecules such as explosives using the energy of the molecular sensor.
  • the present invention is based on cancer detection, and the following configurations 1 to 7 and other configurations are utilized for designing the energy level of the sensor electrode of the cancer diagnostic sensor.
  • the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected;
  • an anode configured to have a redox potential lower than the energy level of the valence band of the detection target material.
  • the energy level of the cathode is designed to be higher than that of the detection target material, and the energy level of the anode is designed to be lower than that of the detection target material.
  • the electrons can be moved to the anode.
  • the relationship between the energy level c of the valence band of the positive electrode, the energy level e of the valence band of the detection target material, and the energy level a of the valence band of the negative electrode is as follows.
  • the selectivity for the substance to be detected increases as the energy level difference between the cathode and the anode becomes smaller.
  • the technique according to the configuration 1 of the present invention is preferably used when detecting a substance having a radical in a natural state such as nitrogen oxides (NOx) or hydrogen peroxide.
  • a substance having a radical in a natural state such as nitrogen oxides (NOx) or hydrogen peroxide.
  • the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected
  • An anode configured to have a redox potential lower than the energy level of the conduction band of the detection target material
  • an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the detection target material can be excited with a conduction band, when the detection target material is introduced between the cathode and the anode.
  • the excitation energy supplied from the supply unit excites the electrons in the valence band of the target material into the conduction band, the electrons excited in the conduction band move to the anode, and are holes in the valence band of the material to be detected. It is characterized by the technical configuration that the energy level is set so that the process of moving is accomplished.
  • excitation energy for example, light
  • excitation energy for example, light
  • the electrons in the band are excited by the conduction band, and the electrons excited in the band are transferred to the anode having an energy level lower than the energy level of the band.
  • the electrons are moved from the cathode to the positive holes generated in the valence band of the detection target material, and the current is proportional to the number of molecules of the detection target material by repeating the above process as long as the excitation energy is supplied. Is to flow.
  • the electrons in the valence band of the detection target material cannot move to the anode. It is excited to conduct the excited electrons to the anode by using the energy level of the excited electrons.
  • a band filled with electrons is called a valence band, and its highest trajectory is called a HOMO.
  • the band in which the electron is empty is called a conduction band, the lowest orbit is called LUMO, and the energy between the homo and lumo is called bandgap energy (Eg).
  • Eg bandgap energy
  • the configuration 2 of the present invention supplies energy above the bandgap energy through an excitation energy supply unit to excite electrons in the valence band of the detection target to a conduction band to raise the energy level to the anode. Is to make the electron transfer.
  • the excitation energy supply unit is characterized in that it is composed of any one or more of an optical energy supply unit, an electromagnetic wave energy supply unit, or a thermal energy supply unit for supplying energy above the band gap energy between the valence band and the conduction band.
  • the excitation energy supply unit configures excitation energy using light energy, electromagnetic wave energy, or thermal energy, and in some cases, excitation energy may be configured by using two or more energy sources together. For example, it may be configured to supply a predetermined amount of excitation energy with light energy and to supply a predetermined amount of excitation energy with thermal energy. This configuration is intended to be used when one energy source cannot supply excitation energy of the desired size.
  • electromagnetic wave includes both heat and light, but is used for convenience of description.
  • the light irradiated by the optical energy supply unit is characterized by consisting of one or more lights having different wavelengths and brightness.
  • the light source irradiated by the light energy supply unit is characterized in that the LED light source having a different wavelength, or a laser light source having a different wavelength, a halogen lamp, a mercury lamp, or any one of xenon lamp.
  • Such an optical energy supply unit is for supplying different bandgap energy by designing an amount of excitation energy by wavelength or brightness.
  • the band gap energy can be supplied to all the mobile induction materials by using one light separately. That is, it can be configured to supply excitation energy to a plurality of moving induction materials by using one light source that supplies energy above the largest bandgap energy.
  • the electromagnetic wave supplied from the electromagnetic wave energy supply unit is characterized by consisting of one or more electromagnetic waves having different wavelengths and intensities.
  • the electromagnetic wave energy supply unit is for supplying different bandgap energy by designing the amount of excitation energy by wavelength or intensity.
  • electromagnetic waves such as 1.0 GHz, 1.2 GHz, and 2 GHz may be used.
  • the heat irradiated by the heat energy supply unit is characterized by consisting of one or more heat having different temperatures and intensities.
  • the thermal energy supply unit is designed to supply different bandgap energy by designing an amount of excitation energy by temperature and intensity.
  • it can be comprised so that heat, such as 1,000 degreeC heat and 1,500 degreeC heat, may be supplied.
  • the anode or cathode is preferably made of a transparent electrode.
  • a transparent electrode is intended to allow light emitted from the excitation energy supply to be transmitted through the detection target material.
  • the transparent electrode is transparent conducting oxide (TCO), F-doped [SnO2] fluorine-doped tin oxide, Transparent electrodes such as ITO (Indium tin oxide), AZO (Al-doped ZnO: aluminum doped zinc oxide), GZO (Ga-doped ZnO: galvanized doped zinc oxide) may be used.
  • the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected
  • An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material
  • the anode side is configured such that the energy level of the redox potential of the valence band is lower than that of the valence band of the substance to be detected, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode.
  • an excitation energy supply unit for supplying excitation energy to excite electrons in the valence band of the anode-side movement inducing material to a conduction band, when the detection target material is introduced between the cathode and the anode. Electrons in the valence band of the anode-side induction material are excited as conduction bands by the excitation energy supplied from an excitation energy supply unit, electrons excited in the conduction band of the cathode-side transport induction material are moved to the anode, and the anode-side movement is performed.
  • the technical configuration is characterized in that the energy level is set so that the electrons of the detection target material move to the holes generated in the valence band of the inductive material, and the electrons move from the cathode to the holes generated in the valence band of the detection target material. do.
  • Configuration 3 of the present invention configured as described above is characterized in that an electron transfer path is designed by further configuring an anode-side movement inducing material between the detection target material and the anode.
  • an electron transport path is designed through the electron donated from the detection target material by further configuring an anode-side movement induction material having an energy level lower than the energy level of the valence band of the detection target material.
  • the anode-side movement inducing material or the cathode-side movement inducing material is characterized in that it is composed of any one or more of a fullerene, a fullerene salt, ion-containing fullerenes, pigments, or polymers of ion-containing fullerenes and pigments.
  • the fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, C96.
  • the ion contained in the fullerene is any one of lithium, sodium, potassium, cesium, magnesium, calcium, or strontium.
  • the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, MDMO-PPV, MEH-PPV It is characterized by one or more of a high molecular polymer or derivatives thereof.
  • P3HT poly-3-hexyl thiophene
  • P3HT poly p-phenylene
  • poly p-phenylene vinylene polyaniline
  • polypyrrole PEDOT, P3OT, POPT
  • MDMO-PPV MDMO-PPV
  • MEH-PPV MEH-PPV It is characterized by one or more of a high molecular polymer or derivatives thereof.
  • FIG. 20A shows the inclusion of ions in C60 fullerene
  • FIG. 20B shows the binding of ionic inclusion fullerene and a pigment
  • 20c is a conceptual diagram showing excitation of electrons by light energy.
  • Lithium-included fullerene has an advantage that the energy level of the redox potential of the valence band is very low, thereby broadening the range of a target to be detected.
  • lithium-encapsulated fullerene has a high quantum yield (IPCE: Incident Photon to Current Efficiency) has the advantage of improving the measurement sensitivity.
  • the quantum yield indicates the ratio of the number of molecules and the number of photons absorbed, which actually caused a chemical change in the photochemical reaction.
  • the anode-side movement inducing material, or cathode-side movement inducing material is characterized in that it is included in the positive electrode, or the negative electrode by using electrophoresis (electrophoresis).
  • FIG. 21 is a diagram showing the electrophoresis of the fullerene-pigment polymer 122a on the positive electrode 121a.
  • the anode-side movement inducing material or cathode-side movement inducing material may be a material having energy levels of various redox potentials, such as [TiO2], [SnO2], by using such a mobile induction material more precise and accurate energy level Can be designed.
  • Configuration 4 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 4, the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; Anode-side shifting where the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode.
  • excitation energy for supplying excitation energy to excite the electrons in the valence band of the anode-side moving induction material to the conduction band excitation energy for supplying excitation energy for electrons in the valence band of the detection target material to the conduction band.
  • the detection target material When the detection target material is introduced between the cathode and the anode, first, the electrons in the valence band of the anode-side moving induction material by the excitation energy supplied from the excitation energy supply unit Electrons excited by the conduction band of the anode-side moving inducing material move to the anode, and second, electrons in the valence band of the detection target material are excited by the excitation energy supplied from the excitation energy supply unit, Electrons excited by the conduction band of the detection target material are holes generated in the valence band of the anode-side transfer inducing material. And, third, an energy level is set so that a process of moving electrons from the cathode to the holes formed in the valence band of the detection target material is made.
  • the molecular sensor in designing the electron migration path according to the inflow of the detection target material, is configured by exciting the electrons in the valence band of the detection target material and the anode-side movement induction material with a conduction band. There is a characteristic.
  • the negative electrode configured to have a redox potential lower than the energy level of the valence band of the detection target material to be detected
  • An anode configured to have a redox potential lower than the energy level of the valence band of the detection target material
  • the cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material.
  • an excitation energy supply unit for supplying excitation energy to excite the electrons in the valence band of the cathode-side movement inducing material to the conduction band, when the detection target material is introduced between the cathode and the anode.
  • the configuration 5 of the present invention configured as described above is characterized in that when the energy level of the detection target material is higher than that of the cathode, smooth electron transfer can be performed by the cathode-side movement inducing substance.
  • the configuration 6, as shown in Figure 6, the negative electrode configured to have a redox potential lower than the energy level of the valence band of the detection target material to be detected;
  • An anode configured to have a redox potential lower than the energy level of the conduction band of the detection target material;
  • the cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material.
  • the electrons in the valence band of the detection target material is excited by the excitation energy supplied from the excitation energy supply unit, Electrons excited by the conduction band of the detection target material move to the anode, and second, electrons in the valence band of the cathode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the cathode side
  • the electrons excited by the conduction band of the mobile induction material move to the hole formed in the valence band of the detection target material.
  • the process of the electron transfer from the cathode to the electron hole occurs in the valence band of the cathode-side movement inducer done so that the energy level is set, characterized in that on the technical configuration.
  • the molecular sensor in designing an electron migration path according to the inflow of the detection target material, is configured by exciting the electrons in the valence band of the detection target material and the cathode-side moving induction material with a conduction band. There is a characteristic.
  • a configuration 7 includes: a cathode configured to have a redox potential lower than the energy level of the valence band of a detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; The anode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the substance to be detected, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the redox level of the anode.
  • Mobile derivatives The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material.
  • the electrons in the valence band of the positive electrode-side moving induction material by the excitation energy supplied from the excitation energy supply unit
  • Electrons excited by the conduction band and excited by the conduction band of the anode-side transport inducing material move to the anode
  • electrons of the detection target material move to the holes generated in the valence band of the anode-side transport inducing material.
  • the electrons in the valence band of the cathode-side mobile induction material are excited by the excitation energy supplied from the excitation energy supply unit.
  • the technical configuration is characterized by the fact that the energy level is set so that the process of movement takes place.
  • Configuration 7 of the present invention configured as described above is characterized by configuring the molecular sensor by designing the electron transfer path according to the inflow of the detection target material using the anode-side induction material and the cathode-side movement induction material.
  • Configuration 8 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 8, the negative electrode configured to have a redox potential lower than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; Anode-side shifting where the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode.
  • the cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material.
  • Mobile derivatives And supplying excitation energy so that the electrons in the valence band of the anode-side mobile induction material can be excited with a conduction band, and supplying excitation energy so that electrons in the valence band of the cathode-side moving inductive material can be excited with a conduction band.
  • an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the detection target material can be excited with a conduction band.
  • the electrons in the magnetic field are excited by the conduction band, the electrons excited by the conduction band of the cathode-side transport inducing material move to the hole formed in the valence band of the detection target material, and fourth, the electrons generated in the valence band of the cathode-side transport inducing material It is characterized by the technical configuration that the energy level is set so that the process of electrons move from the cathode to the positive hole.
  • the anode-side movement induction material and the cathode-side movement induction material in designing the electron transfer path according to the inflow of the detection target material using the anode-side induction material and the cathode-side movement induction material, the anode-side movement induction material and the cathode-side movement induction material And constituting a molecular sensor by exciting the detection target material.
  • the anode-side movement inducing material for inducing the movement of the donated electrons to the anode is characterized in that it is composed of one or more.
  • the first anode-side movement induction for receiving electrons from the detection target material is shown.
  • the energy level of the conduction band of the material is set to be higher than the energy level of the valence band of the next anode-side inductive material, and the energy level of the conduction band of the anode-side mobile inductive material that contributes electrons to the anode is the energy level of the anode.
  • the energy level of the anode-side mobile induction material in the intermediate stage is set higher than the energy level of the valence band of the anode-side mobile inductive material in the next stage. It is characterized by setting the level below the energy level of the conduction band of the anode-side mobile induction material in the previous stage.
  • Such a configuration enables the detection of a detection target material by using a plurality of anode-side moving induction materials, and enables a more accurate energy level design for the detection target material.
  • the cathode-side movement inducing material for inducing the movement of the electrons donated from the cathode to the detection target material is characterized in that it is composed of one or more.
  • the energy level of the conduction band of the first cathode-side movement inducing substance that receives electrons from the cathode is The energy level of the conduction band of the cathode-side moving inductive material which is higher than the energy level of the valence band of the cathode-side moving induction material and donates electrons to the holes generated in the valence band of the detection material is determined by The energy level of the cathode-side mobile induction materials in the middle stage is set higher than the energy level of the valence band, and the energy level of the conduction band is set higher than that of the valence band of the cathode-side mobile induction material in the next stage. In other words, the energy level of the valence band is set lower than that of the conduction band of the cathode-side mobile inductive material in the previous stage. It shall be.
  • This configuration allows the detection of the detection target material by using a plurality of cathode-side moving induction materials, which allows for more accurate energy level design for the detection target material.
  • the detection unit 110 for detecting the flow of electrons according to the detection target material characterized in that it further comprises a.
  • the detection unit 110 detects the flow of electrons moving from the cathode to the anode and calculates the amount, as well as whether or not the substance to be detected is present. That is, the current and the voltage between the positive electrode and the negative electrode are detected to detect whether or not the detection target material flows in and its amount.
  • the detection unit detects one or more of Cyclic Voltammetry (CV), Chrono Amperometry (CA), Chrono Potentiommetry (CP), Stripping Voltammetry (SV), or Linear Sweep Voltammetry (LSV) of a target substance. Detecting the presence and amount of the substance.
  • CV Cyclic Voltammetry
  • CA Chrono Amperometry
  • CP Chrono Potentiommetry
  • SV Stripping Voltammetry
  • LSV Linear Sweep Voltammetry
  • the presence or the amount of the detection target material is detected by measuring the CV, or CA, or CP, or SV, or LSV of the detection target material using a potentiostat. do.
  • FIG. 23 is a circuit diagram showing a simplified configuration of a potentiostat.
  • the detection target material is detected through a working electrode (W), a reference electrode (RE), and a counter electrode (CE). can do. That is, after constructing the working electrode (W) using a moving induction material (anode-side moving induction material, cathode side moving induction material), after obtaining the CV, CA, CP, SV, LSV, etc. By analyzing this, it is possible to precisely determine the presence and amount of the detection target material.
  • a moving induction material anode-side moving induction material, cathode side moving induction material
  • the detection unit is characterized by detecting the presence and amount of the detection target material by detecting the quantum yield (IPCE: Incident Photon to Current Efficiency) according to the wavelength of the light source supplied to the excitation energy.
  • IPCE Incident Photon to Current Efficiency
  • FIG. 26 shows the quantum yield (IPCE) according to the wavelength of the light source.
  • IPCE quantum yield
  • the quantum yield according to the wavelength varies depending on the material. Therefore, it is possible to know the presence or absence of the detection target material by using the characteristics of the quantum yield curvature.
  • the quantum yield graph of Fig. 26A has a maximum at about 440 nm, a second peak value at 560 nm, and a third order peak value at 620 nm, and this characteristic (peak value, wavelength, slope, peak interval, etc.). ) Can be determined whether or not the substance to be detected.
  • the display unit 160 for displaying information on the detection target material characterized in that it further comprises a configuration.
  • the display unit 160 preferably includes a visual display unit 161 that visually displays information on the flow of electrons according to the detection of a detection target material, and an auditory display unit 162 that is acoustically displayed.
  • the communication unit 170 for transmitting information on the detection of the detection target material to the outside further comprises.
  • the data storage unit 140 for storing information on the detection of the detection target material further comprises.
  • reference numeral 150 denotes a controller
  • 180 denotes a power supply unit for supplying operating power to each component.
  • an FTO (F-doped [SnO2]) transparent electrode is used as the anode
  • platinum (Pt) is used as the cathode
  • titanium dioxide (TiO2) and lithium are used as the anode-side inductive materials.
  • containing-fullerene hexafluorotitanate phosphate salt - one in toluene ([Li + @ C60] [ PF6]) to the (material arising as a cause of cancer) configure the sensor electrode unit, and the memorization of material through the sensor electrode used ( Toluene) will be described as an example.
  • the present embodiment will be described by further comprising an excitation energy supply unit for supplying excitation energy to the anode-side movement inducing material.
  • the excitation energy supply unit will be described with an example of supplying light energy.
  • the detection unit for detecting the flow of electrons from the cathode to the anode when the detection material (toluene) is introduced into the sensor electrode portion, and the detection information (detection process, detection conditions, detection results, etc.)
  • a display unit for displaying, a data storage unit for storing the same, and a communication unit for exchanging information on the detection with an external device will be described as an example.
  • the detection of toluene contained in air will be described as an example. Therefore, the sensor electrode unit will be described with an example in which a structure in which air flows between the cathode and the anode is configured. Air (exhalation) containing the detection target material is supplied to the sensor electrode unit using a pumping device.
  • platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode.
  • toluene which is a detection target material
  • contacts the cathode made of platinum (Pt) it has an energy level structure in which electrons can move from the cathode as holes generated in the valence band of toluene, which is a detection target, due to the difference in energy levels.
  • toluene which is a detection target material to be detected, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inductive material having a lower energy level is required.
  • [Li + @ C60] [PF6 ⁇ ] having an energy level of -7.70 eV in the valence band is used as the anode-side first moving inducer.
  • the energy level of the valence band of [Li + @ C60] [PF6 ⁇ ] used as the anode-side first moving inducer is lower than the energy level of the valence band of toluene as the detection target material at ⁇ 6.55 eV. the electrons that [Li + @ C60] [PF6 -] will have the energy level structure that can move electron hole generated in the valence band.
  • Titanium dioxide has -6.21eV energy level in valence band and -3.21eV energy level in conduction band. do. Then, the electron excited in the conduction band of [TiO2] has an energy level structure that can move to the anode.
  • the excitation of the light source need 2.8eV or more power with a wavelength of 457nm
  • the [TiO2] cheukje anode 2 move inducer has a 413nm
  • a power of 3.0 eV or more with a light source having a wavelength is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions. For example, a halogen lamp that meets the above conditions can be used.
  • FIG. 17 illustrates the energy level and the corresponding material designed through the above process, and as shown in the drawing, when toluene as the detection target material is introduced, electrons are moved from the cathode to the anode through two excitation processes according to the energy level. It is designed to move.
  • the cathode 121 and the cathode 124 are mounted inside the case 125, and operation power is supplied to the anode 121 and the cathode 124 through the power supply unit 180.
  • the sensor 110 is connected to the detector 110 so as to detect a current flowing between the anode 121 and the cathode 124.
  • the case 125 is formed of a transparent material (eg, glass, quartz, etc.) on the surface on which the anode 121, which is a transparent electrode, is mounted, and light supplied from the light source 131, which is the excitation energy supply unit 130. It is comprised so that it may irradiate to the positive electrode 121 which is this transparent electrode.
  • a transparent material eg, glass, quartz, etc.
  • the case 125 may be configured such that a light source irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion where the anode is mounted.
  • reference numeral 122a denotes an anode-side first moving inducer and 122b denotes an anode-side second movement inducing substance, respectively, and reference numeral 1 denotes air (exhalation) containing toluene as a detection target substance. Indicates.
  • the air (exhalation) 1 passes through the inside of the sensor electrode part 120 by a pump (not shown) located at the rear of the sensor electrode part 120, and a detailed description thereof will be omitted.
  • the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the system according to the present embodiment.
  • Configure The power supply unit 180 supplies operating power to each component.
  • the controller 150 is configured as a microprocessor or a computer system
  • the data storage 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. desirable.
  • the data storage unit 140 stores a detection result of the detection target material and a data table indicating a correlation between the amount of detection target material and the amount of current.
  • the light energy irradiated from the light source 131 is [Li + @ C60] [where the anode-side first moving inducer 122a is used. PF6 ⁇ ] and [TiO2], the anode-side second moving inducer 122b, supply excitation energy.
  • the electrons in the valence band of [TiO2], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO2].
  • the energy level of electrons excited by the conduction band of [TiO2] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.
  • the electrons in the valence band of the anode-side first moving inducer [Li + @ C60] [PF6-] are excited to the conduction band, and the [Li + @ C60] [PF6-] A hole is generated in the valence band of.
  • the energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO2], which is the anode-side second moving inducer.
  • the excited electrons move to the hole formed in the valence band of [TiO2].
  • the detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.
  • the controller 150 detects whether or not current flows through the detection unit 110 to determine whether or not toluene as a detection target material is present, and determines the amount of toluene as a detection target material from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the target substance stored in the data storage unit and the current amount.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, such a process is repeatedly performed to continuously detect a detection target material.
  • the data indicating the amount of toluene detected may be configured to diagnose the degree of cancer by referring to a data table indicating the amount of toluene and the degree of cancer progression.
  • the precision of the lung cancer sensor is described as follows.
  • the number of molecules in the expiration of about 500cc is about 1.19 ⁇ 10 22 .
  • the number of molecules contained in 1 ppt of aerobic gas of 500 cc is
  • the charge amount is about 19pA.
  • the detection unit 110 for detecting the charge amount in the nano-ampere (nA) or pico-ampere (pA) unit is well known, its detailed description is omitted.
  • fullerene and lithium ion-encapsulated fullerene constituting a mobile induction material is about 1nm in size including an electron cloud, the lithium ion containing fullerene and The supramolecular molecule consists of pigments of about 2 nm in size.
  • the 500cc unit contains 1ppt of memorizing substance, and the mobile inducing substance is composed of ultra-molecules (about 2 nm) composed of lithium ion containing fullerene and pigment, the size of the electrode plate to react simultaneously with the memorizing substance is A size of about (0.22 mm ⁇ 0.22 mm) is sufficient.
  • the positive electrode (or negative electrode) may be made of a smaller electrode plate.
  • a lung cancer sensor having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the memorandous substance to move and directly detecting the number of moved electrons.
  • the detection of the detection target material using two anode-side movement inducing materials is not limited to this. That is, as shown in Figs. 1 to 14, the molecular sensor of the present invention is constructed without a moving inducing substance or by using one anode-side inducing substance or one cathode side inducing substance. Or by constructing the molecular sensor of the present invention using a plurality of anode side movement inducing materials or a plurality of cathode side movement inducing materials, or as many anode side movement inducing materials as required and as many cathode side movements as necessary.
  • Fig. 16 is a diagram showing an example of the configuration of the sensor electrode part using both the anode side movement inducing material 122 and the cathode side movement inducing material 123.
  • the light source is supplied with an excitation energy supply unit, and the light source is limited to one, which has been described as an example.
  • the technical spirit of the present invention is not limited thereto. That is, the excitation energy supply unit may be configured using several different light sources, and it may be configured to supply excitation energy using different energy sources.
  • the detection of the detection target material contained in the air has been described as an example, but the technical spirit of the present invention is not limited thereto. In other words, it can be configured to detect the detection target material contained in the liquid.
  • the present invention can be configured to be configured to contain liquids (blood, urine, saliva, other liquids, etc.) or to temporarily stay, rather than to allow air to pass. Reveal.
  • the detection of only one detection target substance has been described as an example, but the technical spirit of the present invention is not limited thereto.
  • it can be configured to detect a plurality of detection target material.
  • it can be configured to detect two or more detection target materials at the same time by using a plurality of anode-side inducing substances, a plurality of cathode-side inducing substances and a plurality of excitation energy supply units.
  • the technical idea of the present invention has been described with the example of detecting toluene, which is a cancerous substance, but the technical idea of the present invention is not limited thereto. That is, it can be configured to detect tuberculosis-related substances to diagnose tuberculosis early, to detect the cause of bad breath by detecting bad breathing substance), and to detect stress levels by detecting stress-causing substances. It can be configured to detect poisonous gas such as sarin gas, dioxin and the like, as well as the molecular sensor according to the present invention can be configured within the scope of the technical idea of the present invention without limiting the detection target material. Put it.
  • potentiostat is used to measure CV, measure CA, measure CP, measure SV, measure LSV, etc., to detect a substance to be detected as well as to measure the amount thereof.
  • [TiO2] and [Li + @ C60] [PF6-] are moved to the FTO transparent electrode to form the working electrode W, and the counter electrode is formed of the platinum electrode Pt.
  • CE a reference electrode (RE) made of silver chloride electrode (AgCl), mounted on a quartz glass test tube, and the target to be detected was placed in an electrolyte solution (eg, acetonitrile) and subjected to CV measurement. The presence and amount of can be measured.
  • 25 is an enlarged graph of a portion of a CV curve, and shows a response according to energy level design of a substance ((curve) curve) and a substance ((curve) curve) to be detected.
  • excitation energy when "a” is periodically switched on and off of light (excitation energy), excitation occurs at the anode-side induction material due to the excitation energy of light, resulting in a large amount of current (light irradiation).
  • the detection target material can be specified by using quantum yield (IPCE) according to the wavelength of the light source supplied with excitation energy as a feature.
  • IPCE quantum yield
  • FIGS. 28 and 29 the present invention is referred to FIGS. 28 and 29 and the drawings of the molecular sensor.
  • the cancer sensor using the energy level according to the present invention further includes a detection unit 110 for detecting the flow of electrons according to the dark matter, as shown in FIG. 15.
  • the detection unit 110 detects the flow of electrons moving from the cathode to the anode and calculates the amount, as well as whether the memorandous material is present. That is, the current and the voltage between the positive electrode and the negative electrode are detected to detect whether the memorandum is introduced and the amount thereof is detected.
  • the display unit 160 for indicating the information on the flow of electrons according to the memorizing material; it characterized in that it further comprises a configuration.
  • the display unit 160 preferably includes a visual display unit 161 that visually displays information on the detection of a memorandum and an auditory display unit 162 that is auditory.
  • the communication unit 170 for transmitting the information on the memorizing substance detection to the outside further comprises.
  • the communication unit 170, the wired communication unit 171 for transmitting the information on the memorizing substance detection to a wire (dedicated line, dedicated network, Internet, etc.), and the information on the memorizing substance detection wireless (wireless communication, mobile communication, Short-range wireless communication, Wi-Fi, Bluetooth, etc.) is preferably composed of a wireless communication unit 172 for transmitting.
  • the data storage unit 140 for storing the information on the memorandum detection, characterized in that it further comprises.
  • reference numeral 150 denotes a controller
  • 180 denotes a power supply unit for supplying operating power to each component.
  • Example 1 the detection of 2,6-diisopropyl phenol (2,6-Diisopropylphenol), which is one of memorizing substances, will be described as an example.
  • Example 1 an FTO (F-doped [SnO 2]) transparent electrode is used as the anode and platinum (Pt) is used as the cathode.
  • FTO F-doped [SnO 2]
  • Pt platinum
  • Example 1 fullerene [C60] is used as an anode side movement inducing substance, and it demonstrates as an example.
  • the sensor electrode part according to the first embodiment uses FTO as the anode, electrophoreses [C60] to the FTO, and uses platinum (Pt) as the cathode.
  • the excitation energy supply unit for supplying excitation energy to the anode-side movement inducing material is further configured, and the excitation energy supply unit will be described as an example of supplying optical energy.
  • the memorizing substance (2,6-diisoprophylphenol) when introduced into the sensor electrode unit, a detector for detecting the flow of electrons moving from the cathode to the anode, and the detection information (detection process, A display unit for displaying detection conditions, detection results, etc.), a data storage unit for storing the detection conditions, and a communication unit for exchanging information on the detection with an external device will be described as an example.
  • the detection of 2, 6- diisoprofil phenol contained in air (exhalation) is demonstrated as an example. Therefore, the sensor electrode unit will be described with an example in which a structure in which air flows between the cathode and the anode is configured.
  • the air (exhalation) containing the memorizing substance is supplied to the sensor electrode unit by using a pumping device.
  • Example 1 for detecting 2,6-diisoprophylphenol is described below with reference to FIG.
  • the energy level based on the vacuum of the valence band of 2,6-diisoprophylphenol, a memorized substance, is -5.93 eV, and the energy level of the conduction band is -0.01 eV. Therefore, the energy level of the negative electrode requires an electrode having an energy level higher than -5.93 eV, which is the energy level of the valence band of the memorized substance 2,6-diisoprophylphenol.
  • platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode.
  • 2,6-diisoprophylphenol the memorizing substance to be detected in Example 1, has a low energy level of -5.93 eV in the valence band, and thus an anode-side inducing substance having a lower energy level is required.
  • [C60] having an energy level of -6.72 eV in the valence band is used as the anode-side inductive material.
  • the energy level of the valence band of [C60] used as the anode-side inducing substance is lower than the energy level of the valence band of the 2,6-diisoprophylphenol, which is the base material, is -5.93 eV.
  • the electrons in the valence band of soprophyllphenol have an energy level structure that can move to the positive holes generated in the valence band of [C60].
  • the energy level of the conduction band of [C60], which is the anode-side inductive substance, is -3.89 eV
  • the energy level of the valence band of the FTO used as the anode is -4.85 eV
  • the electrons excited in the conduction band of [C60] are anodes. It has an energy level structure that can move to.
  • Figure 23 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, once the excitation process according to the energy level when the 2,6-diisoprophylphenol which is a memorandous material is introduced It is designed to move electrons from cathode to anode via
  • the anode 121 and the cathode 124 are mounted inside the case 125 to form the sensor electrode 120 according to the first embodiment.
  • the operating power is supplied to the positive electrode 121 and the negative electrode 124 through a power supply unit 180, and the detection unit 110 is connected to detect a current flowing between the positive electrode 121 and the negative electrode 124. .
  • the case 125 is formed of a transparent material (eg, glass, quartz, etc.) on the surface on which the anode 121, which is a transparent electrode, is mounted, and light supplied from the light source 131, which is the excitation energy supply unit 130. It is comprised so that it may irradiate to the positive electrode 121 which is this transparent electrode.
  • a transparent material eg, glass, quartz, etc.
  • the case 125 may be configured such that light irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion where the anode is mounted.
  • reference numeral 122 denotes an anode-side moving inducer
  • 1 denotes air (exhalation) containing 2,6-diisoprophylphenol, which is a memorandous substance.
  • the air (exhalation) 1 passes through the inside of the sensor electrode part 120 by a pump (not shown) located at the rear of the sensor electrode part 120, and a detailed description thereof will be omitted.
  • the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the first embodiment. Configure the system.
  • the power supply unit 180 supplies operating power to each component.
  • the controller 150 is configured as a microprocessor or a computer system
  • the data storage 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. desirable.
  • the data storage unit 140 stores a result of the detection of the memorized substance and a data table indicating a correlation between the amount of the substance to be detected and the amount of current.
  • the excitation energy is supplied to [C60] that the light energy irradiated from the light source 131 is the anode-side movement inducing material 122 Done.
  • the electrons in the valence band of [C60], which is the anode-side movement inducing material, are excited with a conduction band, and a hole is generated in the valence band of [C60].
  • the energy level of the electrons excited by the conduction band of [C60] is -3.89 eV, which is higher than the energy level of -4.85 eV of the valence band of the anode FTO, and the electrons excited by the conduction band move to the anode FTO.
  • the detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.
  • the controller 150 detects whether current flows through the detector 110 to determine whether 2,6-diisoprophylphenol, which is a memorandous substance, is present, and the memorized substance is determined from the amount of current.
  • the amount of 2,6-diisoprophylphenol is determined. That is, the amount of 2,6-diisoprophylphenol introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.
  • the presence or absence of a memorandous substance is detected and the presence or absence of cancer cells is determined, and the extent of cancer is determined by the amount of the memorandum.
  • Two or more types of cancers detected in the same sample are determined by the composition ratio of the cancer-causing substance.
  • the progress of cancer is determined by referring to the data table indicating the amount of cancer and the progress of cancer, and the type of cancer is determined by referring to the data table of the composition and the type of cancer.
  • the precision of the lung cancer sensor is described as follows.
  • the number of molecules in the expiration of about 500cc is about 1.19 ⁇ 10 22 .
  • the number of molecules contained in 1 ppt of aerobic gas of 500 cc is
  • the charge amount is about 19pA.
  • the detection unit 110 for detecting the charge amount in the nano-ampere (nA) or pico-ampere (pA) unit is well known, its detailed description is omitted.
  • fullerene and lithium ion-encapsulated fullerene constituting a mobile induction material is about 1nm in size including an electron cloud, the lithium ion containing fullerene and The supramolecular molecule consists of pigments of about 2 nm in size.
  • the 500cc unit contains 1ppt of memorizing substance, and the mobile inducing substance is composed of ultra-molecules (about 2 nm) composed of lithium ion containing fullerene and pigment, the size of the electrode plate to react simultaneously with the memorizing substance is A size of about (0.22 mm ⁇ 0.22 mm) is sufficient.
  • the positive electrode (or negative electrode) may be made of a smaller electrode plate.
  • a lung cancer sensor having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the memorandous substance to move and directly detecting the number of moved electrons.
  • Example 2 the detection of toluene, which is one of memorizing substances, will be described as an example.
  • Example 2 as in Example 1, FTO is used as the positive electrode and platinum (Pt) is used as the negative electrode.
  • Pt platinum
  • Example 2 titanium dioxide (TiO2) and anode-side first lithium-included fullerene hexafluorophosphate salt ([Li + c60] [PF6-]) were used as the anode-side second moving inducer. It demonstrates as an example.
  • the sensor electrode part according to the first embodiment uses FTO as an anode, electrophoreses [TiO2] and [Li + c60] [PF6-] to the FTO, and uses platinum (Pt) as the cathode.
  • the excitation energy supply unit for supplying excitation energy to [TiO2] and [Li + c60] [PF6-] is further configured, and the excitation energy supply unit will be described with an example of supplying optical energy.
  • a detection unit, a display unit, a data storage unit, and a communication unit are described as an example, and the detection of toluene contained in air (exhalation) will be described as an example. .
  • platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode.
  • toluene which is a memorized substance
  • a cathode made of platinum (Pt) has an energy level structure in which electrons can move from the cathode to holes formed in the valence band of toluene, which is a memorized substance, by the energy level difference.
  • Toluene which is a memorized substance to be detected in Example 2, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inductive substance having a lower energy level is required.
  • [Li + @ C60] [PF6-] having an energy level of -7.70eV in the valence band is used as the anode-side first inducing substance.
  • the energy level of the valence band of [Li + @ C60] [PF6-] which is used as the anode-side first moving inducer, is lower than the energy level of the valence band of the toluene, which is the base material, of -6.55 eV.
  • the electrons have an energy level structure that can move to the positive holes in the valence band of [Li + @ C60] [PF6-].
  • the energy level of the conduction band of [Li + @ C60] [PF6-], the anode-side first induction material, is -4.90 eV
  • the energy level of the valence band of the anode FTO is -4.85 eV.
  • What is needed is a material consisting of a valence band with an energy level lower than eV and a conduction band with an energy level higher than -4.85 eV.
  • Titanium dioxide has the energy level of the valence band of -6.21 eV and the conduction band of energy of -3.21 eV, which satisfies the above conditions. do. Then, the electrons excited in the conduction band of [TiO 2] have an energy level structure that can move to the anode.
  • the positive holes in the magnetic field cause the electrons to move in the platinum (Pt) cathode.
  • [PF6-] which is the anode-side first mobile induction material, requires a power of 2.8 eV or more with a light source having a wavelength of 457 nm, and a wavelength of 413 nm for the [TiO2], which is an anode-side second mobile inductive material. Power of 3.0 eV or more is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions.
  • Figure 18 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, when toluene is a memorandous substance is introduced into the electron from the cathode to the anode through two excitation processes according to the energy level It is designed to move.
  • the cathode 121 and the cathode 124 are mounted inside the case 125, and operation power is supplied to the anode 121 and the cathode 124 through the power supply unit 180.
  • the sensor 110 is connected to the detector 110 so as to detect a current flowing between the anode 121 and the cathode 124.
  • the case 125 has a surface on which the anode 121, which is a transparent electrode, is mounted, or the entire case is made of a transparent material, and the light supplied from the light source 131, which is the excitation energy supply unit 130, is the anode 121, which is a transparent electrode. Configure it to be investigated.
  • reference numeral 122a denotes an anode-side first moving inducer
  • 122b denotes an anode-side second moving inducer
  • (1) represents air (exhalation) containing toluene, which is a memorizing substance.
  • the air (exhalation) 1 is configured to pass through the inside of the sensor electrode part 120 by a pump (not shown) located at the rear of the sensor electrode part 120.
  • the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the second embodiment. Configure the system.
  • the power supply unit 180 supplies operating power to each component.
  • the light energy irradiated from the light source 131 is [Li + @ C60] [PF6] being the anode-side first moving inducer 122a.
  • Excitation energy is supplied to [TiO 2], which is the negative electrode-side second moving inducer 122b.
  • the electrons in the valence band of [TiO2], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO2].
  • the energy level of electrons excited by the conduction band of [TiO2] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.
  • the electrons in the valence band of the anode-side first moving inducer [Li + @ C60] [PF6-] are excited to the conduction band, and the [Li + @ C60] [PF6-] A hole is generated in the valence band of.
  • the energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO2], which is the anode-side second moving inducer.
  • the excited electrons are moved to the holes generated in the valence band of [TiO 2].
  • the detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.
  • the control unit 150 detects whether current flows through the detection unit 110 to determine whether or not toluene, which is a memorandant, is present, and determines the amount of toluene, which is a memorized substance, from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.
  • the presence of cancer cells is detected by the presence or absence of toluene, which is a cancerous substance, and the progress of cancer is determined by the amount of the cancerous substance.
  • the type of cancer is determined by the composition ratio of two or more cancer-causing substances detected in the same sample (for example, the composition ratio of toluene and 2,6-diisoprophylphenol, or toluene, 2,6-diisoprophylphenol, 2- Composition of methyl pyrazine, cyclohexanone, etc.)
  • the progress of cancer is determined by referring to the data table indicating the amount of cancer and the progress of cancer, and the type of cancer is determined by referring to the data table of the composition and the type of cancer.
  • the present invention is not limited to this. That is, as shown in Figs. 1 to 14, the arm sensor of the present invention is configured without a moving induction material, or the cancer sensor of the present invention using a plurality of anode-side movement inducing materials or a plurality of cathode-side movement inducing materials. Or it can be understood that the cancer sensor according to the present invention can be configured by using both the required number of the anode-side induction material and the required number of cathode-side movement inducing material.
  • Fig. 16 is a diagram showing an example of the configuration of the sensor electrode part using both the anode side movement inducing material 122 and the cathode side movement inducing material 123.
  • the light source is supplied with an excitation energy supply unit, and the light source is limited to one, which has been described as an example.
  • the technical spirit of the present invention is not limited thereto. That is, the excitation energy supply unit may be configured using several different light sources, and it may be configured to supply excitation energy using different energy sources.
  • the present invention can be configured to detect the memorizing substance contained in the liquid.
  • the present invention can be configured to be configured to contain liquids (blood, urine, saliva, other liquids, etc.) or to temporarily stay, rather than to allow air to pass. Reveal.
  • the technical idea of the present invention is not limited thereto.
  • it can be configured to detect a plurality of memorandous substances.
  • it can be configured to detect two or more memorizing substances at the same time by using a plurality of anode-side inducing substances or a plurality of cathode-side inducing substances and a plurality of excitation energy supply units.
  • the technical idea of the present invention has been described with an example of detecting toluene and 2,6-diisoprophylphenol in the base material, but the technical idea of the present invention is not limited thereto. That is, it can be configured to detect toluene, 2,6-diisoprophylphenol, 2-methylpyrazine, cyclohexanone, and other memorandants.
  • the third embodiment according to the present invention is to capture the exhalation, and to use it to diagnose cancer, especially lung cancer.
  • the sensor electrode portion 120 is designed for the energy level of the redox potential to move the electrons from the cathode to the anode via a memorandum material contained in the expiration;
  • An excitation energy supply unit 130 for supplying excitation energy of electrons to the sensor electrode portion;
  • a detection unit 110 for detecting electron movement of the sensor electrode unit 120;
  • a display unit 160 showing the detection contents of the detection unit 110;
  • a data storage unit 140 for storing detection contents of the detection unit;
  • Communication unit 170 for transmitting the detection information;
  • a control unit 150 connected to the sensor electrode unit 120, the excitation energy supply unit 130, the detection unit 110, the data storage unit 140, the display unit 160, and the communication unit 170;
  • a power supply unit 180 for supplying operation power to each of the components, and detecting and displaying a memorizing substance in the exhalation flowed into the sensor electrode unit 120.
  • the present invention is such that when the subject breath is introduced between the cathode and the anode of the sensor electrode unit 120, the sensor to move the electron from the cathode to the anode via the electrons donated from the memorandum included in the breath
  • the energy level of the redox potential of each component constituting the electrode part is designed.
  • the energy level is designed so that the number of electrons proportional to the memorandum contained in the exhalation moves from the cathode to the anode, and the presence or absence of the memorandum is detected by detecting whether the electrons move (current flow). It determines whether or not, by detecting the degree of movement of the electrons (current amount) to accurately determine the amount of the memorizing substance introduced, and whether the lung cancer has occurred and whether or not the cancer occurs from the type and amount of the memorizing substance, the data storage unit The data is stored in the display unit 140, displayed on the display unit 160, and transmitted to the external device through the communication unit 170.
  • the memorandum Since the movement of electrons is proportional to the number of molecules of the memorandum, the memorandum can be detected in molecular units, and real-time detection is possible by indicating the amount of the memorandum as an amount of current.
  • the breathing apparatus 190 for collecting the breath of the subject characterized in that it further comprises.
  • the exhalation collecting device 190 is for easily collecting the exhalation of the subject to supply to the sensor electrode unit 120.
  • the memorandum is a cancer metabolite that is caused by cancer, and the discovery of this memorandum means that there are cancer cells in the body.
  • Memorandizers include toluene, 2,6-diisopropylphenol, 2-methylpyrazine, cyclohexanone, and the like.
  • the type of the memorizing substance is determined, the ratio of each memorizing substance is judged to determine the type of cancer, and the amount of the memorizing substance is detected to determine the progress of the cancer.
  • the excitation energy supply unit 130 may include an optical energy supply unit (not shown), an electromagnetic wave energy supply unit (not shown), or a thermal energy supply unit (not shown) for supplying energy above the band gap energy between the valence band and the conduction band as described above. It is characterized by consisting of any one or more of).
  • the display unit 160 preferably includes a visual display unit 161 that visually displays information on the detection of a memorandum and an auditory display unit 162 that is auditory.
  • the communication unit 170, the wired communication unit 171 for transmitting the information on the memorizing substance detection to a wire (dedicated line, dedicated network, Internet, etc.), and the information on the memorizing substance detection wireless (wireless communication, mobile communication, Short-range wireless communication, Wi-Fi, Bluetooth, etc.) is preferably composed of a wireless communication unit 172 for transmitting.
  • the sensor electrode 120 applied to the third embodiment of the present invention is the same as Figs. 21 to 23, the energy level design of the configuration 1 to 7 and the other configuration of the first embodiment is used.
  • the exhalation collecting device 190 fits an exhalation pocket 193 into the inside of the quantitative jacket 194, and an exhalation inlet pipe 191 and one side of the exhalation pocket 193. It is provided with the inflow opening and closing means 192, and is provided with the air outlet pipe 196 and the outflow opening and closing means 197 on the opposite side.
  • Example 1 for detecting 2,6-diisoprofil phenol is described with reference to FIG.
  • the energy level based on the vacuum of the valence band of 2,6-diisoprophylphenol, a memorized substance, is -5.93 eV, and the energy level of the conduction band is -0.01 eV. Therefore, the energy level of the negative electrode requires an electrode having an energy level higher than -5.93 eV, which is the energy level of the valence band of the memorized substance 2,6-diisoprophylphenol.
  • platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode.
  • 2,6-diisoprophylphenol which is a memorized substance to be detected, has a low energy level of -5.93 eV in the valence band, and thus an anode-side inductive substance having a lower energy level is required.
  • [C60] having an energy level of -6.72 eV in the valence band is used as the anode-side inductive material.
  • the energy level of the valence band of [C60] used as the anode-side inducing substance is lower than the energy level of the valence band of the 2,6-diisoprophylphenol, which is the base material, is -5.93 eV.
  • the electrons in the valence band of soprophyllphenol have an energy level structure that can move to the positive holes generated in the valence band of [C60].
  • the energy level of the conduction band of [C60], which is the anode-side inductive substance, is -3.89 eV
  • the energy level of the valence band of the FTO used as the anode is -4.85 eV
  • the electrons excited in the conduction band of [C60] are anodes. It has an energy level structure that can move to.
  • Figure 29 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, once the excitation process according to the energy level when the 2,6-diisoprophylphenol which is a memorandous material is introduced It is designed to move electrons from cathode to anode via
  • the sensor electrode unit 120 is configured by mounting the anode 121 and the cathode 124 in the case 125.
  • the operating power is supplied to the positive electrode 121 and the negative electrode 124 through a power supply unit 180, and the detection unit 110 is connected to detect a current flowing between the positive electrode 121 and the negative electrode 124. .
  • the case 125 is formed of a transparent material (eg, glass, quartz, etc.) on the surface on which the anode 121, which is a transparent electrode, is mounted, and light supplied from the light source 131, which is the excitation energy supply unit 130. It is comprised so that it may irradiate to the positive electrode 121 which is this transparent electrode.
  • a transparent material eg, glass, quartz, etc.
  • the case 125 may be configured such that the light irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion where the anode is mounted.
  • reference numeral 122 denotes an anode-side movement inducing substance
  • (1) denotes an exhalation (exhalation) containing 2,6-diisoprophylphenol which is a memorizing substance.
  • exhalation (exhalation) 1 passes through the inside of the sensor electrode unit 120 by a pump (not shown) located at the rear of the sensor electrode unit 120, and a detailed description thereof will be omitted.
  • the aerobic collecting device 190 is coupled to the sensor electrode unit 120 configured as described above through a coupling structure.
  • the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the first embodiment. Configure the system.
  • the power supply unit 180 supplies operating power to each component.
  • the controller 150 is configured as a microprocessor or a computer system
  • the data storage 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. desirable.
  • the data storage unit 140 stores a detection result of 2,6-diisoprophyl phenol, which is a memorizing substance, and a data table showing a correlation between the amount of 2,6-diisoprophyl phenol and the amount of current.
  • exhalation is collected.
  • the inflow opening and closing means 192 is opened by the blowing force as shown in Fig. 32 (b), and the exhalation pocket 193 This swells and exhalation is collected in the collecting space 195.
  • the exhalation collecting device 190 is attached to the sensor electrode unit 120. Then, the exhalation opening means 197 provided in the exhalation outlet pipe 196 by the exhalation induction pipe 127 is opened to supply the exhalation to the sensor electrode unit 120 through the exhalation induction pipe 127.
  • Figure 32 (d) shows that when the exhalation pocket 193 is made of a flexible material such as rubber, the exhalation flows out through the exhalation guide pipe 127 by its elastic force
  • Figure 28 (e) When the exhalation pocket 193 is made of a material having no elasticity, such as vinyl, it shows that exhalation is supplied to the sensor electrode unit 120 through the fan 126.
  • the exhalation preferably uses a fan 126, as shown in Figure 32 (e).
  • a fan 126 As shown in Figure 32 (e).
  • the fan 126 it is possible to control the amount of exhaled air supplied and whether it is supplied.
  • the light source 131 of the excitation energy supply unit 130 is turned on (ON), The light energy irradiated from the light source 131 supplies excitation energy to [C60], which is the anode-side movement inducing material 122.
  • the electrons in the valence band of [C60], which is the anode-side movement inducing material, are excited with a conduction band, and a hole is generated in the valence band of [C60].
  • the energy level of the electrons excited by the conduction band of [C60] is -3.89 eV, which is higher than the energy level of -4.85 eV of the valence band of the anode FTO, and the electrons excited by the conduction band move to the anode FTO.
  • the detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.
  • the controller 150 detects whether current flows through the detector 110 to determine whether 2,6-diisoprophylphenol, which is a memorandous substance, is present, and the memorized substance is determined from the amount of current.
  • the amount of 2,6-diisoprophylphenol is determined. That is, the amount of 2,6-diisoprophylphenol introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.
  • the presence or absence of a memorandum contained in the expiration is detected whether the presence of cancer cells, and the extent of cancer is determined by the amount of the memorandum.
  • Two or more types of cancers detected in the same sample are determined by the composition ratio of the cancer-causing substance.
  • the progress of cancer is determined by referring to the data table indicating the amount of cancer and the progress of cancer, and the type of cancer is determined by referring to the data table of the composition and the type of cancer.
  • the precision of the lung cancer sensor is described as follows.
  • the number of molecules in the expiration of about 500cc is about 1.19 ⁇ 10 22 .
  • the number of molecules contained in 1 ppt of aerobic gas of 500 cc is
  • the charge amount is about 19pA.
  • the detection unit 110 for detecting the charge amount in the nano-ampere (nA) or pico-ampere (pA) unit is well known, its detailed description is omitted.
  • fullerene and lithium ion-encapsulated fullerene constituting a mobile induction material is about 1nm in size including an electron cloud, the lithium ion containing fullerene and The supramolecular molecule consists of pigments of about 2 nm in size.
  • the 500cc unit contains 1ppt of memorizing substance, and the mobile inducing substance is composed of ultra-molecules (about 2 nm) composed of lithium ion containing fullerene and pigment, the size of the electrode plate to react simultaneously with the memorizing substance is A size of about (0.22 mm ⁇ 0.22 mm) is sufficient.
  • the positive electrode (or negative electrode) may be made of a smaller electrode plate.
  • a lung cancer sensor having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the memorandous substance to move and directly detecting the number of moved electrons.
  • Example 2 the detection of toluene, which is one of the cancer-causing substances that occur when lung cancer occurs, will be described as an example.
  • Example 2 as in Example 1, FTO is used as the positive electrode and platinum (Pt) is used as the negative electrode.
  • Pt platinum
  • titanium dioxide (TiO 2) and the positive electrode 1 lithium-pothofullerene hexafluorophosphate salt ([Li + c60] [PF6-]) were used as the anode-side second moving inducer.
  • the example used is demonstrated.
  • the sensor electrode part according to the present Example 2 uses FTO as an anode, electrophoreses [TiO2] and [Li + c60] [PF6-] to the FTO, and uses platinum (Pt) as the cathode. do.
  • the excitation energy supply unit for supplying excitation energy to [TiO2] and [Li + c60] [PF6-] is further configured, and the excitation energy supply unit will be described with an example of supplying optical energy.
  • a detection unit, a display unit, a data storage unit, and a communication unit are described as an example, and the detection of toluene contained in the exhalation (exhalation) will be described as an example. .
  • platinum (Pt) whose energy level of the valence band is -5.93 eV and the energy level of the conduction band is -5.12 eV is used as the cathode.
  • toluene which is a memorized substance
  • a cathode made of platinum (Pt) has an energy level structure in which electrons can move from the cathode to holes formed in the valence band of toluene, which is a memorized substance, due to the difference in energy levels.
  • Toluene which is a memorized substance detected in ⁇ Example 2>, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inductive substance having a lower energy level is required.
  • [Li + @ C60] [PF6-] having the valence band energy level of ⁇ 7.70 eV is used as the anode-side first moving inducing substance.
  • the energy level of the valence band of [Li + @ C60] [PF6-] which is used as the anode-side first moving inducer, is lower than the energy level of the valence band of the toluene, which is the base material, of -6.55 eV.
  • the electrons have an energy level structure that can move to the positive holes in the valence band of [Li + @ C60] [PF6-].
  • the energy level of the conduction band of [Li + @ C60] [PF6-], the anode-side first induction material, is -4.90 eV
  • the energy level of the valence band of the anode FTO is -4.85 eV.
  • What is needed is a material consisting of a valence band with an energy level lower than eV and a conduction band with an energy level higher than -4.85 eV.
  • Titanium dioxide has the energy level of the valence band of -6.21 eV and the conduction band of energy of -3.21 eV, which satisfies the above conditions. do. Then, the electrons excited in the conduction band of [TiO 2] have an energy level structure that can move to the anode.
  • the positive holes in the magnetic field cause the electrons to move in the platinum (Pt) cathode.
  • [PF6-] which is the anode-side first mobile induction material, requires a power of 2.8 eV or more with a light source having a wavelength of 457 nm, and a wavelength of 413 nm for the [TiO2], which is an anode-side second mobile inductive material. Power of 3.0 eV or more is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions.
  • Figure 30 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, when toluene is a memorandous material is introduced into the electron from the cathode to the anode through two excitation processes according to the energy level It is designed to move.
  • the cathode 121 and the cathode 124 are mounted inside the case 125, and operating power is supplied to the anode 121 and the cathode 124 through the power supply unit 180.
  • the sensor electrode unit 120 according to the second embodiment is configured by connecting the detection unit 110 so as to supply and detect a current flowing between the anode 121 and the cathode 124.
  • the case 125 has a surface on which the anode 121, which is a transparent electrode, is mounted, or the entire case is made of a transparent material, and the light supplied from the light source 131, which is the excitation energy supply unit 130, is the anode 121, which is a transparent electrode. Configure it to be investigated.
  • reference numeral 122a denotes an anode-side first moving inducer
  • 122b denotes an anode-side second moving inducer
  • (1) denotes an exhalation (exhalation) containing toluene, which is a cancerous substance.
  • the exhalation (exhalation) 1 is configured to pass through the inside of the sensor electrode 120 by a pump (not shown) located in the rear of the sensor electrode 120.
  • the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the second embodiment. Configure the system.
  • the power supply unit 180 supplies operating power to each component.
  • the data storage unit 140 stores a result of detection of toluene and a data table indicating a correlation between the amount of toluene and the amount of current.
  • the light source 131 of the excitation energy supply unit 130 When the exhaled air collected in the exhalation trap device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, the light source 131 of the excitation energy supply unit 130 is turned on (ON), The light energy irradiated from the light source 131 supplies excitation energy to [Li + @ C60] [PF6-], which is the anode-side first movement inducing material 122a, and [TiO2], which is the anode-side second movement inducing material 122b. do.
  • the electrons in the valence band of [TiO2], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO2].
  • the energy level of electrons excited by the conduction band of [TiO2] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.
  • the electrons in the valence band of the anode-side first moving inducer [Li + @ C60] [PF6-] are excited to the conduction band, and the [Li + @ C60] [PF6-] A hole is generated in the valence band of.
  • the energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO2], which is the anode-side second moving inducer.
  • the excited electrons are moved to the holes generated in the valence band of [TiO 2].
  • the detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.
  • the control unit 150 detects whether current flows through the detection unit 110 to determine whether or not toluene, which is a memorandant, is present, and determines the amount of toluene, which is a memorized substance, from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.
  • the presence of cancer cells is detected by the presence or absence of toluene, which is a cancerous substance, and the progress of cancer is determined by the amount of the cancerous substance.
  • the type of cancer is determined by the composition ratio of two or more cancer-causing substances detected in the same sample (for example, the composition ratio of toluene and 2,6-diisoprophylphenol, or toluene, 2,6-diisoprophylphenol, 2- Composition of methyl pyrazine, cyclohexanone, etc.)
  • the progress of cancer is determined by referring to the data table indicating the amount of cancer and the progress of cancer, and the type of cancer is determined by referring to the data table of the composition and the type of cancer.
  • a fourth embodiment according to the present invention relates to a portable cancer diagnosis system using energy levels.
  • This system uses electrons from the cathode to the anode, especially through donations from memorandum (a substance that is caused by cancer) contained in body fluids (blood, urine, sweat, tears, runny nose, etc.).
  • memorandum a substance that is caused by cancer
  • body fluids blood, urine, sweat, tears, runny nose, etc.
  • the first and second anode energy level designs are constructed in the same manner as the energy level designs of the second and third embodiments, that is, the second and third embodiments based on FIGS.
  • the electrode portion is as follows.
  • the first anode 121a, the cathode 124, and the second anode 121b are zigzag formed on the transparent substrate.
  • One side of the first positive electrode 121a, the negative electrode 124 and the second positive electrode 121b is provided with a connection pattern so as to be inserted into and connected to the connector 120b provided in the portable arm diagnosis apparatus 100 according to the present embodiment.
  • the sensor electrode unit 120 according to the embodiment is configured.
  • the first anode 121a and the second cathode 121b are doped with a moving induction material by electrophoresis.
  • the first anode 121a, the cathode 124, and the second anode 121b are provided with an absorbent cloth 126 of a thin film, and when the body fluid is dropped onto the absorbent cloth 126, the first anode is spread evenly.
  • the medicine may be evenly contacted with the 121a, the cathode 124, and the second anode 121b.
  • the detection units 110a and 110b are connected to detect a current flowing between the second anodes 121b.
  • the portable cancer diagnosis apparatus 100 is provided with a connector 120b to which the sensor electrode part 120a is connected, and each electrode of the sensor electrode part 120a is provided.
  • the light source 131a of the excitation energy supply unit 130 is positioned below the first anode, the cathode, and the second anode, and is configured to supply light energy to the sensor electrode unit 120a through a transparent window.
  • the light source 131a of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection units 110a and 110b are applied to the sensor electrode unit 120a. Connect it. Thereafter, the detectors 110a and 110b, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, the communication unit 170, and the switch unit 190 are connected to the control unit 150. It connects and comprises the detection system which concerns on a present Example.
  • the power supply unit 180 supplies operating power to each component.
  • the controller 150 is configured as a microprocessor or a small computer system.
  • the data storage unit 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. This is preferred.
  • the visual display unit 161 of the display unit 160 includes a touch screen 161a, and the auditory display unit 162 includes a speaker 162a embedded in the portable cancer diagnosis apparatus 100, and the communication unit 170 Wired communication unit 171 of the) is preferably configured to communicate through the USB connection device (171a).
  • the wireless communication device 172 is composed of Bluetooth and Wi-Fi (not shown).
  • the switch unit 190 is configured on the touch screen that forms the button-type switch 191 and the visual display unit 161a.
  • the data storage unit 140 includes a detection result of the 2,6-diisoprophylphenol phenol, which is a memorizing substance, a data table showing the correlation between the amount of the 2,6-diisoprophyl phenol and the current amount, the detection result of toluene, A data table and the like showing the correlation between the amount of toluene and the amount of current are stored.
  • the sensor electrode portion 120a is mounted on the connector 120b.
  • the body fluid dropped on the absorbent cloth 126 is evenly spread to contact the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b evenly.
  • This initial detection is for detecting the current value by the body fluid itself in a state where the excitation energy supply unit 130 is not operated, that is, there is no electron movement by the memorandous substance.
  • This initial detection value is for calculating only the value of the electron transfer which causes the memorandable substance compared with the detection value by the memorable substance.
  • the light source 131a of the excitation energy supply unit 130 is turned on to detect electron movement in the state where the excitation energy is supplied to the sensor electrode unit 120a. Then, the electron transfer by the memorandum contained in the body fluid occurs to detect the value including the value by the memorandum in the initial detection value, the initial detection value is removed from the detection value containing the memorandum.
  • the electron transfer value by the memorandum can be known, and the kind and the progress of the cancer can be determined from the presence, the amount, and the composition ratio of each memorandum.
  • the first anode 121a detects 2,6-diisoprophylphenol, which is a memorandous substance contained in the body fluid, and uses [C60] as an anode-side inducing substance, it will be described. .
  • electrons in the valence band of the anode-side movement inducing material [C60] are excited as conduction bands, and holes are generated in the valence band of [C60].
  • the energy level of the electrons excited by the conduction band of [C60] is -3.89 eV, which is higher than the energy level of -4.85 eV of the valence band of the anode FTO, and the electrons excited by the conduction band move to the anode FTO.
  • the first detector 110a detects a current (movement of electrons) flowing between the cathode 124 and the first anode 121a.
  • the controller 150 detects whether a current flows through the first detection unit 110a to determine whether 2,6-diisoprophylphenol, which is a memorandum, is present, and memorizes from the amount of current.
  • the amount of 2,6-diisoprophylphenol which is a substance is determined. That is, the amount of 2,6-diisoprophylphenol introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.
  • toluene which is a memorized substance contained in the body fluid, is detected at the second anode 121b, and [Li + @ C60] [PF6-] is used as the anode-side first movement inducing substance, and the anode-side second movement induction. Since [TiO 2] is used as an example, it will be described.
  • the light energy irradiated from the light source 131a is the anode-side first moving inducing material.
  • Excitation energy is supplied to [Li + @ C60] [PF6-] (122a) and [TiO2], which is the anode-side second moving inducer 122b.
  • the electrons in the valence band of [TiO2], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO2].
  • the energy level of electrons excited by the conduction band of [TiO2] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.
  • the holes (energy level: -6.55eV) in the valence band of toluene are generated in the valence band of [Li + @ C60] [PF6-] which is the anode-side first moving inducer (energy level: -7.70eV) It moves to and the hole is generated in the valence band of toluene.
  • the same process is repeated as long as the excitation energy is supplied from the light source 131a of the excitation energy supply unit 130 to be proportional to the toluene which is the memorized substance from the cathode 124 to the second anode 121b.
  • the number of electrons are constantly moving.
  • the second detector 110b detects a current (movement of electrons) flowing between the cathode 124 and the second anode 121b.
  • the controller 150 determines whether current is flowing through the second detector 110b to determine whether or not toluene, which is a cancerous substance, is present, and determines the amount of toluene, which is a cancerous substance, from the amount of current. Done. That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.
  • the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.
  • the presence of cancer cells is detected by the presence or absence of toluene, which is a cancerous substance, and the progress of cancer is determined by the amount of the cancerous substance.
  • the type of cancer is determined by the composition ratio of two or more cancer-causing substances detected in the same sample (for example, the composition ratio of toluene and 2,6-diisoprophylphenol, or toluene, 2,6-diisoprophylphenol, 2- Composition of methyl pyrazine, cyclohexanone, etc.)
  • the progress of cancer is determined by referring to the data table indicating the amount of cancer and the progress of cancer, and the type of cancer is determined by referring to the data table of the composition and the type of cancer.
  • the precision of the portable cancer diagnostic apparatus according to the present invention will be described as follows. Since the molecular weight of the body fluid varies depending on the type of body fluid, it will be described based on water.
  • the volume of one drop of liquid dropped into the dropper is about 0.05 cc.
  • the detection unit 110 for detecting the charge amount in the nano ampere (nA) or the picoampere (pA) unit is well known, its detailed description is omitted.
  • fullerene and lithium ion-encapsulated fullerene constituting a mobile induction material is about 1nm in size including an electron cloud, the lithium ion containing fullerene and The supramolecular molecule consists of pigments of about 2 nm in size.
  • the mobile inducing substance is composed of ultra-molecules (about 2 nm) composed of lithium ion containing fullerene and a pigment. Should be about (0.22mm ⁇ 0.22mm).
  • a lung cancer diagnosis apparatus having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the memorandant to be moved and directly detecting the number of moved electrons.
  • Urine consists of 95% water and 5% other components (urea, uric acid, etc.).
  • the molecular weight of water is about 18, the molecular weight of urea is about 60, and the molecular weight of uric acid is about 168.
  • Embodiment 5 of the present invention is a portable cancer diagnosis system using a smartphone.
  • the cancer diagnosis system is a portable detection device for detecting a cancer-causing substance by setting the energy level of the redox potential so that electrons are moved from the cathode to the anode via the cancer-causing substance contained in the body fluid, and the portable detection Comparing and analyzing the measured value measured by the device is a cancer diagnostic app indicating the presence or absence of cancer memorandum and cancer, and the cancer diagnostic app is installed, and includes a smart phone for communicating with the mobile detection device.
  • the cancer diagnostic app is to determine the presence of cancer in the presence or absence of the memorandum, and to determine the progress of the cancer by the amount of the memorandum.
  • the basic configuration of the cancer diagnosis system using the smart phone enables the light source 131a of the excitation energy supply unit 130 to be irradiated to the sensor electrode unit 120, and the sensor electrode unit (
  • the detectors 110a and 110b are connected to the 120a. Thereafter, the detectors 110a and 110b, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, the communication unit 170, and the switch unit 190 are connected to the control unit 150.
  • the portable detection device 100 is configured.
  • the power supply unit 180 supplies operating power to each component.
  • the controller 150 is configured as a microprocessor or a small computer system.
  • the data storage unit 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. This is preferred.
  • the visual display unit 161 of the display unit 160 is composed of a touch screen 161a
  • the auditory display unit 162 is composed of a speaker 162a built in the portable detection device 100
  • the communication unit 170 Wired communication unit 171 is preferably configured to communicate through the USB connection device (171a).
  • the wireless communication device 172 is composed of Bluetooth and Wi-Fi (not shown).
  • the switch unit 190 is configured on the touch screen that forms the button-type switch 191 and the visual display unit 161a.
  • the memory (not shown) of the smartphone 200 the data table showing the correlation between the result of the detection of 2,6-diisoprophylphenol phenol, and the amount and current amount of 2,6-diisoprophylphenol, The detection result of toluene, and a data table showing the correlation between the amount of toluene and the amount of current are stored.
  • the sensor electrode portion 120a is mounted on the connector 120b.
  • the body fluid dropped on the absorbent cloth 126 is evenly spread to contact the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b evenly.
  • This initial detection is for detecting the current value by the body fluid itself in a state where the excitation energy supply unit 130 is not operated, that is, there is no electron movement by the memorandous substance.
  • This initial detection value is for calculating only the value of the electron transfer caused by the memorandum substance compared with the detection value by the memorandum substance in the cancer diagnostic app 300.
  • the light source 131a of the excitation energy supply unit 130 is turned on to detect electron movement in the state where the excitation energy is supplied to the sensor electrode unit 120a. Then, the electron transfer by the memorandum contained in the body fluid occurs to detect the value including the value by the memorandum in the initial detection value, the initial detection value is removed from the detection value containing the memorandum.
  • the electron transfer value by the memorandum can be known, and the kind and the progress of the cancer can be determined from the presence, the amount, and the composition ratio of each memorandum.
  • 40 shows a diagnosis process of the cancer diagnosis system using the smart phone.
  • the sensor electrode part of this system is preferably composed of the sensor electrode part of FIGS. 43 to 45 attached thereto.
  • the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b are formed inside the transparent rectangular tube base material.
  • the first anode 121a and the second cathode 121b are doped with a moving induction material by electrophoresis.
  • the operating power is supplied to the first positive electrode 121a, the negative electrode 124 and the second positive electrode 121b through the power supply unit 180, and the first positive electrode 121a, the negative electrode 124,
  • the detectors 110a and 110b are connected to detect a current flowing between the two anodes 121b.
  • the left and right exhalation inlets and outlets of the sensor electrode unit 120a are fitted with an exhalation induction pipe 126a for inducing exhalation and an exhalation exhalation pipe 126b for exhalation. .
  • the mouthpiece 127 is inserted into the exhalation induction pipe 126a so as to inhale it and blow the exhalation.
  • the exhalation passes through the exhalation induction pipe 126a, the inside of the sensor electrode part 120a, and the exhalation outlet pipe 126b, and the first anode 121a configured in the sensor electrode part 120a in the process. ), The cathode 124 and the second anode 121b are uniformly contacted.
  • the excitation energy supply unit 130 is installed at a position capable of supplying optical energy to the sensor electrode unit 120a, and the anode-side moving induction material by energy supplied from the light source 131 of the excitation energy supply unit 130. This is configured to be excited.
  • the basic configuration is as shown in Figs. 41 and 45, and the system is referred to Fig. 35 for the configuration.
  • the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120a, and the detection units 110a and 110b are connected to the sensor electrode unit 120a. Thereafter, the detectors 110a and 110b, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, the communication unit 170, and the switch unit 190 are connected to the control unit 150.
  • the present embodiment is constructed by connecting.
  • the power supply unit 180 supplies operating power to each component.
  • the controller 150 is configured as a microprocessor or a small computer system.
  • the data storage unit 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. This is preferred.
  • the visual display unit 161 of the display unit 160 includes a touch screen 161a, the auditory display unit 162 includes a speaker 162a embedded in the body 100a, and the wired communication unit of the communication unit 170.
  • 171 is preferably configured to communicate via the USB connection device (171a).
  • the wireless communication device 172 is composed of Bluetooth and Wi-Fi (not shown).
  • the switch unit 190 is configured on the touch screen that forms the button-type switch 191 and the visual display unit 161a.
  • the data storage unit 140 includes a detection result of the 2,6-diisoprophylphenol phenol, which is a memorizing substance, a data table showing the correlation between the amount of the 2,6-diisoprophyl phenol and the current amount, the detection result of toluene, A data table and the like showing the correlation between the amount of toluene and the amount of current are stored.
  • the mouthpiece 127 is inserted into the aerobic induction conduit 126a, the operation button of the switch unit 191 is pressed, and the breath is blown into the mouthpiece 127. Then, the exhalation 1 is in contact with the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b of the sensor electrode 120a through the air induction pipe 126a.
  • the controller 150 controls the operations of the light source 131, the first detector 110a, and the second detector 110b of the excitation energy supply unit 130.
  • the value when the light source 131 is turned on and the value when the light source 131 is turned off are respectively detected.
  • the reason why the light source 131 detects the value when it is turned on and the value when it is turned off, is to correct an error from the value and to calculate the electron movement by pure memorized substance. That is, by subtracting the value detected when the light source 131 is turned on from the value detected when the light source 131 is turned off, various sources of error can be eliminated, and the error can be corrected to detect the movement of electrons through the memorized substance. From the presence or absence of the memorizing substance, the amount and the composition ratio of each memorizing substance can determine whether the cancer occurs, the type of cancer, and the progress of the cancer.
  • Embodiment 7 of the present invention relates to a portable lung cancer diagnosis system using a smart phone, as shown in FIG. 46.
  • a short range wireless communication network such as Bluetooth or Wi-Fi or GPS may be used for the portable lung cancer diagnosis system and the mobile phone, and the cancer diagnosis app is installed in the smartphone as in the fifth embodiment.
  • the mouthpiece 127 is inserted into the aerobic induction pipe 126a as in the sixth embodiment, the operation button of the switch unit 191 is pressed, and the breath is injected into the mouthpiece 127. Then, the exhalation 1 is in contact with the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b of the sensor electrode 120a through the air induction pipe 126a.
  • the controller 150 controls the operations of the light source 131, the first detector 110a, and the second detector 110b of the excitation energy supply unit 130.
  • the value when the light source 131 is turned on and the value when the light source 131 is turned off are respectively detected.
  • the detected value is transmitted to the smartphone and can be immediately confirmed by the user.
  • This embodiment relates to a cancer diagnostic system.
  • the sensor electrode unit 120 described in the first to seventh embodiments, the excitation energy supply unit 130 and the exhalation collecting device 210 is configured to be connected to the sensor electrode unit.
  • the collecting device is similar to the collecting device of Example 3, but shows that it can be configured as a tube of a slightly slippery form.
  • the switch unit 190 operated for diagnosing cancer
  • the sensor electrode unit 120 for detecting a cancer-causing substance
  • the sensor electrode unit 120 for detecting a cancer-causing substance
  • An excitation energy supply unit 130 for supplying excitation energy to electrons
  • a detection unit 110 for detecting electron movement of the sensor electrode unit
  • a data storage unit 140 for storing information on the detection of the memorizing substance
  • Consists of a communication unit 170 for communicating with an external device and a control unit 150 for performing cancer diagnosis
  • main body 200 which has a switch part and a detachable part in the upper surface, and a monitor, a display part provided in this main body.
  • the present invention of such a configuration is to diagnose the cancer by connecting the exhalation collected in the collecting device to the sensor electrode.
  • the present invention relates to a cancer diagnosis system using big data, and in particular, to build a database by analyzing and processing a large amount of diagnostic data, and to analyze the cancer detection data requested by the client, cancer occurrence, cancer type, cancer progression degree This is to provide information about.
  • a communication server performing communication
  • a customer management server managing information about subscribers
  • a database server for storing diagnostic data
  • a backup server performing data backup
  • a decision server having a level determining unit capable of determining a value level according to a predetermined decision criterion with respect to information transmitted from one server 12;
  • a filter module for classifying information of an information medium transmitted from the outside; And a main server for controlling the operation of each component.
  • the diagnostic data transmitted from the cancer diagnosis system which is a client system, is analyzed to calculate whether cancer is generated, the type, and the degree of progression.
  • the client cancer diagnosis system which is a client system, is a system that detects a memorandum contained in exhalation or body fluid.
  • the discovery of this memorandum means that there are cancer cells in the body.
  • the memorandum Since the movement of electrons is proportional to the number of molecules of the memorandum, the memorandum can be detected in molecular units, and real-time detection is possible by indicating the amount of the memorandum as an amount of current.
  • Such a system is employed in any one of the system configuration, sensor electrode portion, and energy level design described in the above first to seventh embodiments.
  • the present invention is used in a molecular sensor, a sensor for diagnosing cancer using the molecular sensor, and a system for diagnosing cancer through the cancer diagnostic sensor provided with the cancer diagnostic sensor and collecting the breath.

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Abstract

La présente invention concerne un capteur de molécule capable de détecter avec précision, à un niveau moléculaire, une substance à détecter au moyen de niveaux d'énergie de potentiel d'oxydoréduction. En particulier, les niveaux d'énergie du potentiel d'oxydoréduction d'une substance à détecter sont analysés, et, avec les électrons fournis par la substance à détecter en tant que support, les niveaux d'énergie de la substance d'électrode négative et de la substance d'électrode positive sont configurés de sorte que, lorsque la substance à détecter est introduite, les électrons sont transférés de l'électrode négative à l'électrode positive.
PCT/KR2019/010737 2018-08-23 2019-08-23 Capteur moléculaire et système de diagnostic de cancer utilisant celui-ci WO2020040584A1 (fr)

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KR1020180117018A KR20200037595A (ko) 2018-10-01 2018-10-01 암진단용 호기포집장치
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KR20140114005A (ko) * 2012-02-06 2014-09-25 더 리전트 오브 더 유니버시티 오브 캘리포니아 휴대용 신속 진단 테스트 리더기
KR20170041850A (ko) * 2014-08-08 2017-04-17 퀀텀-에스아이 인코포레이티드 분자를 프로빙, 검출 및 분석하기 위한 외부 광원을 갖는 통합 디바이스
KR20170065015A (ko) * 2015-12-02 2017-06-12 한양대학교 에리카산학협력단 헤모글로빈 측정용 전기화학센서 및 그 제조방법

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