WO2020035445A1 - Système et procédé d'éclairage - Google Patents

Système et procédé d'éclairage Download PDF

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Publication number
WO2020035445A1
WO2020035445A1 PCT/EP2019/071579 EP2019071579W WO2020035445A1 WO 2020035445 A1 WO2020035445 A1 WO 2020035445A1 EP 2019071579 W EP2019071579 W EP 2019071579W WO 2020035445 A1 WO2020035445 A1 WO 2020035445A1
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WIPO (PCT)
Prior art keywords
radiation
vertebrate
relatively
dimmer
programme
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PCT/EP2019/071579
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English (en)
Inventor
Lucas Jozef Maria SCHLANGEN
Raymond Van Ee
Marjolein Dimmie VAN DER ZWAAG
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Signify Holding B.V.
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Application filed by Signify Holding B.V. filed Critical Signify Holding B.V.
Publication of WO2020035445A1 publication Critical patent/WO2020035445A1/fr

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Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B47/00—Circuit arrangements for operating light sources in general, i.e. where the type of light source is not relevant
    • H05B47/10—Controlling the light source
    • H05B47/105—Controlling the light source in response to determined parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment

Definitions

  • the present disclosure relates to a lighting system and a method of operating a lighting system.
  • various lighting systems and lighting schemes have been previously studied to determine the effect of different lighting patterns on animals, particularly on vertebrates including in particular humans and domestic and farm animals.
  • various lighting patterns can be applied so as to phase-shift the circadian rhythms and/or to treat affective disorders. This can help alleviate circadian sleep (phase) disorders and circadian disruptions associated with for example“jet lag”,“social jet lag” and shift work or assist in alleviating affective disorders including for example seasonal affective disorder (SAD).
  • phase circadian sleep
  • SAD seasonal affective disorder
  • a lighting system comprising:
  • a lighting unit configured to output light
  • a controller configured to control the lighting unit to output light so as to provide a programme of alternating periods of relatively brighter radiation and relatively dimmer radiation to a vertebrate, wherein the controller is configured to apply the programme at a time either at least approximately centred on a time of occurrence of the minimum core body temperature CBTmin of the vertebrate or is applied during a circadian day of the vertebrate.
  • the circadian day is a time period wherein the endogenous system or peripheral tissue of the vertebrate perceives the time to be daytime (not night time) regardless of whether or not in fact it is daytime based on sunrise/sunset times.
  • the circadian day relates to a time period wherein melatonin is absent from the vertebrate’s system or undetectably low.
  • “Relatively brighter radiation” and“relatively dimmer radiation” in this context are brighter and dimmer with respect to each other.“Relatively brighter radiation” and“relatively dimmer radiation” may be with reference to radiation to which one of the five photoreceptors (i.e. rods, melanopsin-containing ipRGCs (intrinsically photosensitive retinal ganglion cells), and S-, M- and L-cones) is sensitive, or to radiation to which any of the five photoreceptors (i.e. rods, melanopsin-containing ipRGCs (intrinsically photosensitive retinal ganglion cells), and S-, M- and L-cones) is sensitive, or to radiation to which any of the five photoreceptors (i.e. rods, melanopsin-containing ipRGCs (intrinsically photosensitive retinal ganglion cells), and S-, M- and L-cones) is sensitive, or to radiation
  • the radiation may for example be brighter/dimmer with respect to only a certain spectral bandwidth, for instance only to the blue part of the spectrum. In such a case, other parts of the spectrum may be at the same intensity during the alternating periods.
  • the lighting system may in general cause“light” or radiation to be output that is in the visible part of the spectrum and/or the non-visible part of the spectrum.
  • The“visible part of the spectrum” may be defined according to the subject that is being illuminated or irradiated. For example, for humans, the visible spectrum is typically regarded as wavelengths in the range 390 to 700 nanometres.
  • CBT min typically means“minimum core body temperature”.
  • CBT min is often also used in the present disclosure as an abbreviation of the“time of occurrence of the CBT min ”. Whether the time of occurrence or the actual temperature is meant will be clear from the context.
  • the controller is configured to receive as an input a measure of the core body temperature CBT of a said vertebrate so as to be able to determine a time of occurrence of the CBT min of the vertebrate.
  • a sensor such as for example a thermometer, may provide measurements of the CBT of the vertebrate to the controller.
  • Other options include use of a temperature sensing pill and devices that measure skin temperature or gradient of skin temperature.
  • the controller is configured to use an estimate of the time of occurrence of the CBT min of the vertebrate.
  • the controller is configured to receive as an input a measure of the circadian phase of the vertebrate and to estimate the time of occurrence of the CBT min of the vertebrate from the received measure of the circadian phase of the vertebrate.
  • the measure of the circadian phase of the vertebrate may be for example some“marker” or a related physical quantity or habitual patterns of the vertebrate from which the circadian phase of the vertebrate can be deduced.
  • the circadian phase of the vertebrate is zero at CBT min .
  • the time of occurrence of the CBT min of the vertebrate will in general be vertebrate specific. For example, for humans, the CBT min is known to occur in general around 4.30am to 5am or so.
  • the CBT min may for example be based on the current sleep/awake pattern of the vertebrate.
  • dim light melatonin (DLM) onset i.e. the onset of melatonin secretion under dim light conditions
  • DLM onset typically occurs approximately 8 hours before CBT min , so for example DLM onset + 8 hrs or so could be used to centre the programme.
  • typically dim light melatonin (DLM) offset occurs 2-3 hrs later then the time of the CBT min , so instead of centring the program with respect to CBT min or DLM onset + 8 hrs say, it can also be centred with respect to DLM 0ffset -2 hrs or so.
  • DLM typically dim light melatonin
  • controller is configured such that, in the case that the programme is approximately centred on the CBT min of the vertebrate, a greater portion of the programme is applied after the CBT min of the vertebrate than before the CBT min of the vertebrate.
  • the programme may be more precisely centred on the CBT min of the vertebrate. That is, the alternating relatively brighter radiation and relatively dimmer radiation may be provided more or less equally spread either side of the time of occurrence of the CBTmin.
  • the controller is configured such that, in the case that the programme is applied during a circadian day of the vertebrate, the relatively brighter radiation is achieved by the lighting unit outputting light of a first intensity and the relatively dimmer radiation is achieved by outputting light from the lighting unit at a lower or zero intensity. This creates a minimum of additional illumination to the environment, i.e.
  • controller may in embodiments be configured to instruct a shading or blinding system to create relative darkness, e.g. by shading part of the windows or lower the blinds, during periods of relatively dimmer radiation.
  • the controller is configured such that the programme has plural cycles of relatively brighter radiation and relatively dimmer radiation, wherein one cycle is one period of relatively brighter radiation preceded or followed by one period of relatively dimmer radiation, and there is more than one cycle of relatively brighter radiation and relatively dimmer radiation in a 24 hour period.
  • controller is configured such that a duration of one period of relatively brighter radiation preceded or followed by one period of relatively dimmer radiation is between 20 minutes and 8 hours.
  • controller and lighting unit are constructed and arranged to apply at least 500 lux of a vertical illuminance at the eye position of the vertebrate during a period of relatively brighter radiation.
  • controller and lighting unit are constructed and arranged to apply less than 50 lux of a vertical illuminance at the eye position of the vertebrate during a period of relatively dimmer radiation.
  • controller and lighting unit are constructed and arranged to apply a colour of the light that is different for the periods of relatively brighter radiation and relatively dimmer radiation.
  • the light that is applied for the relatively brighter radiation may be a yellow light and the light that is applied for the relatively dimmer radiation may be a blue light.
  • a method of operating a lighting system comprising a lighting unit configured to output light so as to provide a programme of alternating periods of relatively brighter radiation and relatively dimmer radiation to a vertebrate, wherein the programme is applied at a time either at least approximately centred on a time of occurrence of the minimum core body temperature CBTmin of the vertebrate or during a circadian day of the vertebrate.
  • the programme has plural cycles of relatively brighter radiation and relatively dimmer radiation, wherein one cycle is one period of relatively brighter radiation preceded or followed by one period of relatively dimmer radiation, and there is more than one cycle of relatively brighter radiation and relatively dimmer radiation in a 24 hour period.
  • a duration of one period of relatively brighter radiation preceded or followed by one period of relatively dimmer radiation is between 20 minutes and 8 hours.
  • the colour of the light that is applied is different for the periods of relatively brighter radiation and relatively dimmer radiation.
  • the method comprises, after applying the programme of alternating periods of relatively brighter radiation and relatively dimmer radiation, subsequently applying brighter and/or dimmer radiation so as to advance or delay the phase of the circadian rhythm of the vertebrate or reintroduce a circadian phase of the vertebrate.
  • the applying the programme of alternating periods of relatively brighter radiation and relatively dimmer radiation may have effectively fully abolished the circadian rhythm.
  • this subsequent application of brighter and/or dimmer radiation after the main programme of alternating periods of relatively brighter radiation and relatively dimmer radiation, can be used to reintroduce a circadian phase of the vertebrate.
  • a method for flattening or destabilizing a circadian rhythm of a vertebrate comprising:
  • a light programme including alternating periods of relatively brighter radiation and relatively dimmer radiation to the vertebrate either at least
  • Figure 1 shows schematically an example of a lighting system.
  • various lighting systems and lighting schemes have been previously studied to determine the effect of different lighting patterns on animals.
  • various lighting patterns can be applied so as to phase-shift the circadian rhythms and/or to treat affective disorders. This can help alleviate circadian sleep disorders and circadian disruptions associated with for example jet lag and shift work or assist in treating affective disorders including for example seasonal affective disorder (SAD).
  • SAD seasonal affective disorder
  • the known systems are not always effective or achieve their desired effects only slowly.
  • examples described herein can be used to“flatten” or “destabilize” the circadian clock of the subject.
  • the master circadian“clock” is contained within the suprachiasmatic nucleus (SCN).
  • SCN is a bilateral nerve cluster (typically of about 20,000 neurons in humans) centred in the hypothalamus region of the brain. Examples described herein lower the firing rate of the neurons in the SCN, which lowers the amplitude of the circadian clock, or spread the firing of neurons over a longer time period. Either way, this in turn enables a subsequent phase shifting of the circadian clock to be carried out more effectively, easily and/or rapidly.
  • the flattening or destabilizing of the circadian clock in this manner makes the circadian clock more receptive to subsequent phase shifting techniques.
  • the flattening or destabilizing of the circadian clock may be carried out without necessarily phase shifting the circadian clock.
  • Phase shifting of the circadian clock may be carried out subsequently.
  • This subsequent phase shifting may be carried out using for example various lighting patterns which may be known for this purpose or using other techniques.
  • FIG. 1 there is shown schematically an example of an overall system according to aspects described herein.
  • the lighting system 2 has one or more lighting units 3, such as for example luminaires.
  • lighting units 3 shown are a table lamp and a number of ceiling-mounted light fittings.
  • Other lighting units 3 may be provided instead or in addition, including for example wall-mounted luminaires and luminaires that are built into a surface of for example an item of furniture or other equipment in the room.
  • Each lighting unit 3 has at least one light source or lamp, such as an LED-based lamp, gas-discharge lamp or filament bulb, etc.
  • One lighting unit may comprise multiple light sources (e.g.
  • the light output from the lighting unit(s) may be controllable in terms of one or more of brightness, colour and spectral power distribution. (For convenience and brevity, hereafter reference will typically be made only to a single lighting unit 3, it being understood that in examples there may be one or more lighting units 3.)
  • the lighting system 2 in use illuminates or irradiates a subject 4 using the lighting unit 3.
  • the subject 4 is a human.
  • Other subjects which may be illuminated in other examples include vertebrates generally, including for example pets, horses, birds, reptiles and other mammals.
  • the vertebrate may be for example a farm animal or a domestic animal.
  • the lighting system 2 has a controller 5.
  • the controller 5 may be for example a computing device having a processor 6, data storage 7, memory 8, etc.
  • the controller 5 is able to communicate with the lighting unit 3 via wireless connections, using an appropriate wireless protocol, such as for example ZigBeeTM, BluetoothTM and/or WiFiTM signals, or using for example infrared (IR) signals, and/or via wired connections, such as for example Ethernet IEEE 802.3 local area networks.
  • the controller 5 provides for overall control of the lighting system 2.
  • the controller 5 may be located in the same area or location as the lighting unit 3 or located elsewhere.
  • the controller 5 controls the lighting unit 3 to output light at selected times.
  • the controller 5 controls the lighting unit 3 to output light at a high intensity for a period of time such that the subject 4 is subjected to relatively brighter radiation for that period of time.
  • the controller 5 then controls the lighting unit 3 to output light at a low intensity or to output no light for a period of time such that the subject 4 is subjected to relatively dimmer radiation for that period of time.
  • the alternating brighter radiation and dimmer radiation may then be stopped or may be continued with at least a further period of relatively bright radiation, optionally followed by a further period of relatively dimmer radiation, and so on.
  • the selected cycle of alternating brighter radiation and dimmer radiation is referred to herein as a programme of alternating relatively brighter radiation and relatively dimmer radiation.
  • the programme may have just one cycle of relatively brighter radiation and relatively dimmer radiation, which may be followed by one more period of relatively brighter radiation and relatively dimmer radiation.
  • the programme may have plural cycles of relatively brighter radiation and relatively dimmer radiation.
  • the programme of alternating relatively brighter radiation and relatively dimmer radiation is either at least approximately centred on the time of the minimum core body temperature CBTmin of the subject 4 or is applied during a circadian day of the subject 4. The effect of this is to flatten or destabilize the circadian clock of the subject 4, as mentioned above.
  • a single controller may control the lighting units in multiple rooms.
  • Such control may further be based on presence detection in the room(s) and/or personal healthcare data of people present in the room(s) (e.g. vital signs parameters, past sleep/wake patterns, jet lag data, shift work data etc.).
  • the controller can also control the transmission characteristics of a medium (such as glasses, a window pane, an electrochromic coating of a window, or the like) between the light emitting/reflecting source and the subject.
  • the core body temperature or CBT of an animal refers generally to the operating temperature of an organism, specifically in deep structures of the body such as the heart and liver, and the blood, as opposed to temperature of peripheral tissues such as the skin.
  • the CBT varies throughout the day, typically in a cycle from a minimum to a maximum and back to the minimum, etc.
  • thermometer probe typically requires insertion of a thermometer probe into the organism.
  • the CBT may be measured and/or monitored using such a probe.
  • Temperature examination in the rectum is the traditional gold standard measurement used to estimate core temperature. However, this may not always be convenient or suitable, depending for example on the subject 4. In other examples, therefore, an indirect method may be used.
  • an ingestible thermistor in capsule form may be swallowed by the subject 4, allowing the temperature inside the digestive tract to be transmitted to an external receiver.
  • oral or ear thermometers may be used to observe trends in body temperature as it is known that, although slightly different, these temperature measurements are well-correlated with core body temperature.
  • Other known techniques for measuring the CBT, or at least providing a measure or estimate of the CBT may be used.
  • identifying the time of the CBT min of the subject 4 may be based on the cycle of CBT of the subject 4 and/or the sleeping/waking pattern of the subject 4.
  • the cycle of the CBT of a human is such that the CBT min typically occurs around 4.30am to 5am or so (i.e. 04:30 to 05:00).
  • the programme of alternating relatively brighter radiation and relatively dimmer radiation is at least approximately centred on the CBT min of the subject 4, this means that the programme may be applied at least approximately centred around 4.30am to 5am or so.
  • CBT min typically occurs about 2 hours before spontaneous natural awakening of the subject (that is, waking without any alarm clocks or any other environmentally- induced wake up signal).
  • dim light melatonin (DLM) onset or DLM offset may be used to identify or estimate the time of the CBT min of the subject 4, as discussed above.
  • the cycle of the CBT of a human is such that core body temperature tends to have the lowest value in the second half of the sleep cycle. Accordingly, the programme may be at least approximately centred around the time when the human subject 4 is determined to be in the second half of a sleep cycle or around 2 hours before the spontaneous natural awakening of the subject 4.
  • the subject 4 may be monitored, using for example cameras, a Philips Actiwatch or other techniques, to determine when the subject is sleeping or awake, and the programme applied accordingly. This may be carried out on an automated basis, with the camera or other monitor devices feeding signals to the controller 5, which in turn controls the lighting unit 3 as required for the programme.
  • the circadian day is a time period wherein the endogenous system of the vertebrate perceives the time to be daytime (not night time) regardless of whether or not in fact it is daytime based on sunrise/sunset times.
  • the circadian day relates to a time period wherein melatonin is absent from the system or undetectably low. This may be for example actually daytime (some time after sunrise and before sunset). Alternatively or additionally, this may be based on some estimate of the time of the circadian day of the subject 4.
  • rhythm shifting of the circadian clock of the subject 4 may then be carried out subsequently in a more effective or rapid manner owing to this flattening or destabilizing of the circadian clock of the subject 4.
  • the programme may be executed by operating the lighting unit 3 to provide the brighter radiation as a number of light pulses.
  • the light pulses may have a duration of for example a few minutes.
  • the lighting unit 3 may be operated so as to provide light of a lower intensity or no light at all.
  • the lighting unit 3 may be operated to provide light pulses for the bright radiation, where the intensity of such light pulses simply adds to the background lighting (which may be daylight).
  • the illuminance from light pulses may be higher than the illuminance from the background lighting and, indeed, the light that is provided by the lighting unit 3 may have a high intensity relative to the background lighting.
  • the lighting unit 3 may be operated so as to provide light of a lower intensity or no light at all, such that the relatively dimmer radiation is provided by the background illumination (even if that is daylight). Because of the intensity difference between the relatively brighter radiation and relatively dimmer radiation, the SCN will perceive the periods of relatively brighter radiation and the periods of relatively dimmer radiation as light and dark cues for its circadian clock.
  • the controller 5 may cause the lighting unit 3 to operate so as to provide alternating relatively brighter radiation and relatively dimmer radiation more or less equally either side of the time of occurrence of the CBT min . That is, there may be for example an equal number of brighter and dark or dim periods occurring either side of the time of the CBT min .
  • the programme may be approximately centred on the minimum core body temperature CBT min of the subject 4. As a particular example, a greater portion of the complete sequence of brighter and dark or dim periods may be applied after the time of the CBT min than before the time of the CBT min .
  • a greater number of brighter and dark or dim periods may be applied after the time of CBT min than before the time of the CBT m in.
  • a greater number of brighter and dark or dim periods may be applied before the time of CBT min than after the time of the CBTmin.
  • the master clock gets conflicting signals from the internal and the external time cues, its entrainment and strength will weaken. In such state, the master clock is more receptive and responsive to new entraining signals, thus enabling larger phase shifts and more rapid and stronger re-entrainment during a subsequent phase-shifting process.
  • Entrainment here means that rhythmic physiological or behavioural events of the subject match their period to that of an environmental oscillation. This corresponds to the interaction between circadian rhythms and the environment. A familiar example is the entrainment of circadian rhythms to the daily light-dark cycle, which ultimately is determined by the Earth's rotation during a day.
  • an environmental entraining light signal will immediately affect the activity of the light responsive ventral SCN.
  • the dorsal part of the SCN by itself is not responsive to light, although the dorsal SCN is influenced by the activity in the ventral SCN.
  • Theory predicts that activity of the dorsal SCN may only respond to an entraining light signal when the activity peak of the dorsal SCN has some overlap with the activity peak of the ventral SCN.
  • any environmental entraining light signal may be able to directly influence/impact activity in both the ventral and the dorsal part of the SCN irrespective of the timing of the light exposure.
  • a flattened circadian rhythm can facilitate repair of a deregulated body clock, enabling greater circadian phase shifts and/or more rapid phase shifts.
  • the SCN rhythm is not flat as it exhibits a pronounced cyclic pattern of activity during a 24 hour cycle. The SCN fires during the habitual wake period (even when there is no light) while the SCN activity is low during the habitual sleep period (normally provided it is dark).
  • phase shifts that are achieved may be greater than if there had been no previous flattening or destabilizing of the circadian clock.
  • An example of a useful application of this is in assisting human subjects to overcome jet lag more quickly.
  • jet lag is a physiological condition that results from alterations to the body's circadian rhythms caused by rapid long-distance trans-meridian (east-west or west-east) travel and can vary in its effect on different people from mild to quite severe. Jet lag is generally attributed to a conflict between external time cues and internal biological rhythms.
  • the phase shifting if carried out following the programme of lighting to flatten or destabilize the circadian clock, may be carried out using for example various lighting patterns which may be known for this purpose or using other techniques. Indeed, if internal circadian rhythms would be completely absent, then, one or more sequences of light pulses or even a period of continuous light exposure might be used to immediately synchronize the internal circadian clock with a specific desired time. For example, a light pulse may be applied at a time when the circadian clock should signal daytime onset so that the phase of the circadian rhythm is re-adjusted to the correct position in time.
  • the specific duration of the brighter periods and/or dimmer periods in the programme may be adapted to the specific effect aimed to be achieved.
  • the duration of dimmer periods may allow for short (power) naps or a singular deep sleep and the duration of the light period may be selected to aim at a maximum response to light.
  • a brighter/dimmer transition may include a yellow/blue transition as high intensity yellow and dimmed blue can have a similar disruptive effect as, or strengthen the effect of, alternating bright white light and darkness. That is, the light that is applied for the relatively brighter radiation may be a yellow (rich) light and the light that is applied for the relatively dimmer radiation may be a blue (rich) light.
  • a blue-to-yellow transition on top of a dim-to-bright transition can strengthen the (circadian rhythm) entraining action (and thus also the (de) regulating effect) of the dim-bright transition. It is understood that the blue-to-yellow transition can be picked up by a different photoreceptor system (with a given combination of photoreceptors) than the bright-to-dim transition (using another combination of photoreceptors), where the (circadian) effects of the two different
  • photoreceptor combinations can eventually add to strengthen each other, thus resulting in a (larger) circadian (regulating or deregulating) effect.
  • the term“yellow light” or the like especially relates to light having a wavelength in the range of about 560-590 nm.
  • the term“yellow light” or the like relates to warm white light with a correlated colour temperature below about 3000K .
  • the term“blue light” or the like especially relates to light having a wavelength in the range of about 440-490 nm (including some violet and cyan hues).
  • the term“blue light” or the like relates to cool white light with a correlated colour temperature above about 4000K.
  • the lighting system 2 is operated such that there is a 15 minute period of brighter radiation followed by a 60 minute of dimmer radiation. This may be repeated once or more than once. In another example, there may be a 15 minute period of dimmer radiation followed by a 60 minute of bright radiation. Again, this may be repeated once or more than once.
  • the use of dimmer periods that are at least around 15 minutes long may allow the subject 4 to have a least a short“power” nap during the dimmer periods.
  • the lighting system 2 is operated such that one cycle of relatively brighter radiation and relatively dimmer or dark radiation has a duration of between 20 minutes and 8 hours.
  • a cycle has a brighter period with duration of Tl and a dimmer or dark period with duration T2 such that one cycle has a duration of (Tl + T2).
  • an illumination at the eye level of the user above XI lux or above Xml melanopic lux may be provided as a vertical illuminance at the eye position of the vertebrate.
  • an illumination at the eye level of the user below around X2 lux or below around Xm2 melanopic lux may be provided as a vertical illuminance at the eye position of the vertebrate.
  • Tl, T2, XI, X2 are given in Table 1 below.
  • the transition (ramp) between XI and X2 can be for example stepwise or sinusoidal or gradual. The transition may be in respect of the intensity of the light or the colour of the light or both. Each light-dim cycle is repeated at least twice in an example. Different colours may be provided for the brighter portions and or the dimmer portions between the successive light-dim cycles.
  • a (wake-up) sound may additionally be provided by some suitable audio output device at the start of the light period.
  • a wake-up sound may be provided to the user at the moment he/she falls asleep or tends to fall asleep during the light (and/or dim) period.
  • the sleep state may be detected by some physiological signal(s), a camera, an Actiwatch or any other input into the system.
  • the programme of alternating light and dim periods may be set depending on the amount of time zones that a person will travel, or the amount of hours that a person wants to shift his/her (working) schedule.
  • phase shifting of the circadian clock of the subject 4 may be carried out subsequent to the flattening or destabilizing of the circadian clock of the subject 4 achieved using a programme as described above.
  • a number of techniques for such phase shifting are possible. Examples include applying or controlling Zeitgebers or time cues, including for example applying bright light or lighting patterns of brighter and dimmer radiation at specific times, melatonin administration, specific food intake patterns, social cues, physical activity, etc.
  • a computer program may be stored/distributed on a suitable medium, such as an optical storage medium or a solid-state medium supplied together with or as part of other hardware, but may also be distributed in other forms, such as via the Internet or other wired or wireless telecommunication systems. Any reference signs in the claims should not be construed as limiting the scope.

Abstract

L'invention concerne une unité d'éclairage (3) qui émet de la lumière de manière à fournir un programme de rayonnement alternatif relativement plus clair et de rayonnement relativement gradateur alternés d'un vertébré (4). Le programme de rayonnement relativement plus clair et de rayonnement relativement gradateur alternés est soit au moins approximativement centré sur un temps d'occurrence de la température corporelle minimale CBTmin du vertébré (4), soit appliqué pendant un jour circadien du vertébré (4).
PCT/EP2019/071579 2018-08-16 2019-08-12 Système et procédé d'éclairage WO2020035445A1 (fr)

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WO2008017979A2 (fr) * 2006-08-07 2008-02-14 Koninklijke Philips Electronics N.V. Système et procédé pour influencer un état photobiologique
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