WO2020019852A1 - Method and apparatus for inhibiting cerebrospinal fluid signal in vascular wall imaging, and device and medium - Google Patents

Method and apparatus for inhibiting cerebrospinal fluid signal in vascular wall imaging, and device and medium Download PDF

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WO2020019852A1
WO2020019852A1 PCT/CN2019/088331 CN2019088331W WO2020019852A1 WO 2020019852 A1 WO2020019852 A1 WO 2020019852A1 CN 2019088331 W CN2019088331 W CN 2019088331W WO 2020019852 A1 WO2020019852 A1 WO 2020019852A1
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angle
inversion
pulse
chain
magnetization vector
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PCT/CN2019/088331
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French (fr)
Chinese (zh)
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郑海荣
刘新
张娜
张磊
贾琳
贾文霄
邹超
梁栋
万丽雯
赵世华
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中国科学院深圳先进技术研究院
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/5635—Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

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  • the invention belongs to the technical field of magnetic resonance imaging, and particularly relates to a method, a device, a device and a medium for suppressing cerebrospinal fluid signals in imaging of a blood vessel wall.
  • Cardiovascular and cerebrovascular diseases have become the most important diseases that threaten human health, and atherosclerotic plaques are an important risk factor for cardiovascular and cerebrovascular diseases. Therefore, it is important to accurately assess the stability of plaques and identify vulnerable plaques for prevention. Stroke events are significant. Because the intracranial arteries are surrounded by cerebrospinal fluid, in order to clearly distinguish the boundaries of vascular walls of the intracranial arteries and the plaques attached to them, it is necessary to simultaneously suppress arterial blood flow and cerebrospinal fluid signals. At present, nutation delay alternate navigation stimulation technology (Nutation for Tailored Excitation, DANTE) can effectively suppress arterial blood flow and cerebrospinal fluid signals.
  • DANTE Nutation delay alternate navigation stimulation technology
  • This technology uses a series of low flip angle pulses and scattered phase gradients to make stationary and moving substances Generates different signals, has very good motion sensitivity, and can effectively suppress flow signals, but it is very sensitive to flow velocity, and the speed of cerebrospinal fluid varies with location, resulting in insufficient inhibition of cerebrospinal fluid around the Willis ring
  • the cerebrospinal fluid signals that are uniform and slow in the flow around the M2 segment of the middle cerebral artery are not completely suppressed, so that the outer boundary of the blood vessel wall cannot be distinguished, which is easy to cause misdiagnosis and is not conducive to artificial intelligence diagnostic analysis.
  • the purpose of the present invention is to provide a method, device, equipment and storage medium for suppressing cerebrospinal fluid signal in imaging of blood vessel wall, which aims to solve the problem that because of the failure to provide an effective method for suppressing cerebrospinal fluid signal in imaging of blood vessel wall, The problems of incomplete suppression of cerebrospinal fluid signals and low recognition of outer boundaries of blood vessel walls in resonance blood vessel wall imaging.
  • the present invention provides a method for inhibiting cerebrospinal fluid signals in imaging of blood vessel walls, the method comprising the following steps:
  • the longitudinal macroscopic magnetization vector obtained in advance is flipped to the XY plane through a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain; a transverse magnetization vector is obtained;
  • the transverse magnetization vector is flipped to a negative Z axis by a third angle inversion pulse in the inversion recovery pulse chain, so as to achieve suppression of a cerebrospinal fluid signal.
  • the present invention provides a cerebrospinal fluid signal suppression device for vascular wall imaging, the device includes:
  • a first inversion unit configured to invert the longitudinal macroscopic magnetization vector obtained in advance to XY through a first inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain during a magnetic resonance vascular wall imaging process A plane to obtain a transverse magnetization vector;
  • a second inversion unit is configured to invert the lateral magnetization vector to a negative Z-axis through a third angle inversion pulse in the inversion recovery pulse chain, so as to achieve suppression of a cerebrospinal fluid signal.
  • the present invention also provides a medical device including a memory, a processor, and a computer program stored in the memory and executable on the processor.
  • the processor is implemented when the processor executes the computer program.
  • the present invention also provides a computer-readable storage medium that stores a computer program that, when executed by a processor, implements a method for suppressing cerebrospinal fluid signals as described above in vascular wall imaging. Described steps.
  • the present invention reverses the longitudinal macroscopic magnetization vector obtained in advance to the XY plane through a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain, thereby obtaining a transverse magnetization.
  • Vector invert the transverse magnetization vector to the negative Z axis by reversing the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal, improving the inhibitory effect of the cerebrospinal fluid signal in magnetic resonance vascular wall imaging, and thereby improving the vascular wall
  • the tissue contrast of the image is conducive to doctor's diagnosis and quantitative analysis.
  • FIG. 1 is a flowchart of implementation of a method for suppressing cerebrospinal fluid signals in vascular wall imaging provided by Embodiment 1 of the present invention
  • FIG. 2 is a schematic structural diagram of a cerebrospinal fluid signal suppression device in vascular wall imaging provided by Embodiment 2 of the present invention
  • FIG. 3 is a schematic structural diagram of a cerebrospinal fluid signal suppression device for vascular wall imaging provided by Embodiment 3 of the present invention.
  • FIG. 4 is a schematic structural diagram of a medical device according to a fourth embodiment of the present invention.
  • FIG. 1 shows the implementation process of the method for suppressing cerebrospinal fluid signals in vascular wall imaging provided in Embodiment 1 of the present invention.
  • FIG. 1 shows the implementation process of the method for suppressing cerebrospinal fluid signals in vascular wall imaging provided in Embodiment 1 of the present invention.
  • the details are as follows:
  • step S101 during the imaging of the magnetic resonance blood vessel wall, the longitudinal macroscopic magnetization vector obtained in advance is flipped to the XY plane by a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain, Obtain the transverse magnetization vector.
  • the embodiments of the present invention are applicable to a medical image processing platform, system, or device, such as a personal computer, a server, and the like.
  • a preset imaging sequence for example, a fast spin echo imaging sequence or a variable spin angle fast spin echo imaging sequence.
  • the human tissue is magnetized to generate a longitudinal macroscopic magnetization vector, and the first angle inversion pulse and the second angle inversion pulse in the pulse chain are restored by a preset inversion to reverse a small amount of the restored longitudinal macromagnetization vector to the XY plane. To obtain the transverse magnetization vector.
  • the first angle inversion pulse and the second angle inversion pulse in the pulse chain invert the previously obtained longitudinal macroscopic magnetization vector to the XY plane, thereby improving the weighting ratio of the T1 image.
  • a pre-emission imaging sequence refocusing pulse is obtained
  • the first and second angle inversion pulses corresponding to the first angle inversion pulse in the inversion recovery pulse chain are calculated.
  • the corresponding second angle, according to the first angle inversion pulse corresponding to the first angle, the second angle inversion pulse corresponding to the second angle, and the third angle inversion pulse corresponding to the preset third angle constitutes a reverse recovery pulse chain.
  • the angle calculation formula is used Calculate the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, thereby improving the contrast between the blood vessel wall and the cerebrospinal fluid, and thereby improving the recognition of the outer boundary of the blood vessel wall .
  • ⁇ max is the maximum flip angle threshold
  • ⁇ max is limited by the voltage peak and power deposition of the RF pulse in the imaging sequence refocusing pulse chain The reversal angle corresponding to the last refocusing pulse in the refocusing pulse chain of the acquired imaging sequence.
  • the inversion recovery pulse chain is formed according to the first angle inversion pulse corresponding to the first angle, the second angle inversion pulse corresponding to the second angle, and the third angle inversion pulse corresponding to the preset third angle, preferably, The third angle corresponding to the third angle inversion pulse is set to 90 °, thereby improving the effect of suppressing cerebrospinal fluid signals with very slow intracranial flow velocity.
  • step S102 the transverse magnetization vector is reversed to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain to achieve suppression of the cerebrospinal fluid signal.
  • the third angle in the pulse chain is recovered by inverting the X-axis. Inverting the pulse reverses the transverse magnetization vector to the negative Z axis. Due to the slow recovery of the cerebrospinal fluid signal, there is almost no magnetization vector of the cerebrospinal fluid signal when the next excitation pulse is performed, which completes the suppression of the cerebrospinal fluid signal, thereby improving the cerebrospinal fluid signal suppression effect.
  • the longitudinal macroscopic magnetization vector obtained in advance is flipped to XY by a first inversion recovery pulse and a second angle inversion pulse in a preset inversion recovery pulse chain.
  • Plane obtain the transverse magnetization vector, and invert the transverse magnetization vector to the negative Z axis by inverting the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal and improving the cerebrospinal fluid signal suppression effect in magnetic resonance blood vessel wall imaging
  • FIG. 2 shows the structure of a cerebrospinal fluid signal suppression device for vascular wall imaging provided in Embodiment 2 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown, including:
  • the first inversion unit 21 is configured to invert the longitudinal macromagnetization vector obtained in advance to a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain during a magnetic resonance vascular wall imaging process. XY plane, obtain the transverse magnetization vector.
  • the embodiments of the present invention are applicable to a medical image processing platform, system, or device, such as a personal computer, a server, and the like.
  • a preset imaging sequence for example, a fast spin echo imaging sequence or a variable spin angle fast spin echo imaging sequence.
  • the human tissue is magnetized to generate a longitudinal macroscopic magnetization vector, and the first angle inversion pulse and the second angle inversion pulse in the pulse chain are restored by a preset inversion to reverse a small amount of the restored longitudinal macromagnetization vector to the XY plane. To obtain the transverse magnetization vector.
  • the first angle inversion pulse and the second angle inversion pulse in the pulse chain invert the previously obtained longitudinal macroscopic magnetization vector to the XY plane, thereby improving the weighting ratio of the T1 image.
  • the second inverting unit 22 is configured to invert the lateral magnetization vector to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, so as to suppress the cerebrospinal fluid signal.
  • the third angle in the pulse chain is recovered by inverting the X-axis. Inverting the pulse reverses the transverse magnetization vector to the negative Z axis. Due to the slow recovery of the cerebrospinal fluid signal, there is almost no magnetization vector of the cerebrospinal fluid signal when the next excitation pulse is performed, which completes the suppression of the cerebrospinal fluid signal, thereby improving the effect of suppressing the cerebrospinal fluid signal.
  • each unit of the cerebrospinal fluid signal suppression device in vascular wall imaging may be implemented by corresponding hardware or software units.
  • Each unit may be an independent software and hardware unit, or may be integrated into one software and hardware unit. This is not intended to limit the invention.
  • FIG. 3 shows a structure of a cerebrospinal fluid signal suppression device in vascular wall imaging provided in Embodiment 3 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown, including:
  • a flip angle acquisition unit 31 is configured to obtain a flip angle corresponding to the last refocusing pulse in the refocusing pulse chain of the imaging sequence emitted in advance during the imaging of the magnetic resonance blood vessel wall.
  • Magnetic resonance blood vessel wall imaging is to generate an echo signal by transmitting a fast spin echo imaging sequence or a fast spin echo imaging sequence with a variable flip angle, and then generate a magnetic resonance blood vessel wall image based on the generated echo signal.
  • the flip angle corresponding to the last refocusing pulse in the refocusing pulse chain of the imaging sequence is obtained.
  • the angle calculation unit 32 is configured to calculate a first angle corresponding to a first angle inversion pulse and a second angle corresponding to a second angle inversion pulse in the inversion recovery pulse chain according to the inversion angle and a preset maximum inversion angle threshold.
  • an angle calculation formula is used Calculate the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, thereby improving the contrast between the blood vessel wall and the cerebrospinal fluid, and thereby improving the recognition of the outer boundary of the blood vessel wall .
  • ⁇ max is the maximum flip angle threshold
  • ⁇ max is limited by the voltage peak and power deposition of the RF pulse in the imaging sequence refocusing pulse chain The reversal angle corresponding to the last refocusing pulse in the refocusing pulse chain of the acquired imaging sequence.
  • the pulse chain constituting unit 33 is configured to form a reverse recovery according to a first angle inversion pulse corresponding to a first angle, a second angle inversion pulse corresponding to a second angle, and a third angle inversion pulse corresponding to a preset third angle. Pulse chain.
  • inversion recovery is constituted by a first angle inversion pulse corresponding to a first angle, a second angle inversion pulse corresponding to a second angle, and a third angle inversion pulse corresponding to a preset third angle.
  • the third angle corresponding to the third angle inversion pulse is set to 90 °, so as to improve the effect of suppressing cerebrospinal fluid signals with very slow intracranial flow velocity.
  • the first inversion unit 34 is configured to invert the longitudinal macromagnetization vector obtained in advance to the first angle inversion pulse and the second angle inversion pulse in a preset inversion recovery pulse chain during the magnetic resonance blood vessel wall imaging. XY plane, obtain the transverse magnetization vector.
  • the human tissue is magnetized to generate a longitudinal macroscopic magnetization vector, and the first in the pulse chain is restored by a preset inversion.
  • the angle inversion pulse and the second angle inversion pulse flip a small amount of recovered longitudinal macroscopic magnetization vectors to the XY plane to obtain a transverse magnetization vector.
  • the first angle inversion pulse and the second angle inversion pulse in the pulse chain invert the previously obtained longitudinal macroscopic magnetization vector to the XY plane, thereby improving the weighting ratio of the T1 image.
  • the second inversion unit 35 is configured to invert the transverse magnetization vector to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, so as to suppress the cerebrospinal fluid signal.
  • the third angle in the pulse chain is recovered by inverting the X-axis. Inverting the pulse reverses the transverse magnetization vector to the negative Z axis. Due to the slow recovery of the cerebrospinal fluid signal, there is almost no magnetization vector of the cerebrospinal fluid signal when the next excitation pulse is performed, which completes the suppression of the cerebrospinal fluid signal, thereby improving the effect of suppressing the cerebrospinal fluid signal.
  • the angle calculation unit 32 includes:
  • Angle calculation subunit 321 for calculating formulas based on angles Calculate the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, where n ⁇ ⁇ 1,2 ⁇ , To invert the nth angle in the recovery pulse chain, ⁇ max is the maximum flip angle threshold, Is the flip angle.
  • the second turning unit 35 includes:
  • the second inversion subunit 351 is configured to invert the transverse magnetization vector to the negative Z-axis by applying a third angle inversion pulse in the inversion recovery pulse chain of the X-axis.
  • each unit of the cerebrospinal fluid signal suppression device in vascular wall imaging may be implemented by corresponding hardware or software units.
  • Each unit may be an independent software and hardware unit, or may be integrated into one software and hardware unit. This is not intended to limit the invention.
  • Embodiment 4 is a diagrammatic representation of Embodiment 4:
  • FIG. 4 shows a structure of a medical device provided in Embodiment 4 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown.
  • the medical device 4 includes a processor 40, a memory 41, and a computer program 42 stored in the memory 41 and executable on the processor 40.
  • the processor 40 executes the computer program 42, the steps in the embodiment of the method for suppressing cerebrospinal fluid signals in the above-mentioned vascular wall imaging are implemented, for example, steps S101 to S102 shown in FIG. 1.
  • the processor 40 executes the computer program 42, the functions of the units in the foregoing device embodiments are realized, for example, the functions of the units 21 to 22 shown in FIG. 2.
  • the longitudinal macroscopic magnetization vector obtained in advance is flipped to XY by a first inversion recovery pulse and a second angle inversion pulse in a preset inversion recovery pulse chain.
  • Plane obtain the transverse magnetization vector, and invert the transverse magnetization vector to the negative Z axis by inverting the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal and improving the cerebrospinal fluid signal suppression effect in magnetic resonance blood vessel wall imaging
  • the medical equipment in the embodiment of the present invention may be a personal computer or a server.
  • the processor 40 in the medical device 4 executes the computer program 42 to implement the method for suppressing cerebrospinal fluid signals in blood vessel wall imaging, reference may be made to the description of the foregoing method embodiments, and details are not described herein again.
  • Embodiment 5 is a diagrammatic representation of Embodiment 5:
  • a computer-readable storage medium stores a computer program.
  • the computer program When the computer program is executed by a processor, the method for suppressing cerebrospinal fluid signals in the above-mentioned vascular wall imaging is described.
  • the steps are, for example, steps S101 to S102 shown in FIG. 1.
  • the computer program when executed by a processor, the functions of the units in the foregoing device embodiments are implemented, for example, the functions of the units 21 to 22 shown in FIG. 2.
  • the longitudinal macroscopic magnetization vector obtained in advance is flipped to XY by a first inversion recovery pulse and a second angle inversion pulse in a preset inversion recovery pulse chain.
  • Plane obtain the transverse magnetization vector, and invert the transverse magnetization vector to the negative Z axis by inverting the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal and improving the cerebrospinal fluid signal suppression effect in magnetic resonance blood vessel wall imaging
  • the computer-readable storage medium of the embodiment of the present invention may include any entity or device capable of carrying computer program code, a recording medium, for example, a memory such as a ROM / RAM, a magnetic disk, an optical disk, a flash memory, or the like.
  • a recording medium for example, a memory such as a ROM / RAM, a magnetic disk, an optical disk, a flash memory, or the like.

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Abstract

Disclosed are a method and apparatus for inhibiting a cerebrospinal fluid signal in vascular wall imaging, and a device and a medium. The method comprises: during magnetic resonance vascular wall imaging, flipping a pre-obtained longitudinal macroscopic magnetization vector to an XY plane through a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain, so as to obtain a transverse magnetization vector (S101); and flipping the transverse magnetization vector to a negative Z axis through a third angle inversion pulse in the inversion recovery pulse chain, so as to realize the inhibition of a cerebrospinal fluid signal (S102). The effect of inhibiting a cerebrospinal fluid signal in magnetic resonance vascular wall imaging is improved, and the tissue contrast of a vascular wall image is thus also improved, thereby facilitating diagnosis and quantitative analysis carried out by a doctor.

Description

血管壁成像中脑脊液信号的抑制方法、装置、设备及介质Method, device, equipment and medium for inhibiting cerebrospinal fluid signal in blood vessel wall imaging 技术领域Technical field
本发明属于磁共振成像技术领域，尤其涉及一种血管壁成像中脑脊液信号的抑制方法、装置、设备及介质。The invention belongs to the technical field of magnetic resonance imaging, and particularly relates to a method, a device, a device and a medium for suppressing cerebrospinal fluid signals in imaging of a blood vessel wall.
背景技术Background technique
心脑血管疾病已成为威胁人类健康的首要疾病，而动脉粥样硬化斑块是导致心脑血管疾病发生的一个重要风险因素，因此准确地评估斑块的稳定性、鉴别易损斑块对于预防脑卒事件具有重要意义。由于颅内动脉被脑脊液包绕，为清晰分辨颅内动脉血管壁的边界和附在其上的斑块，需要同时抑制动脉血流和脑脊液信号。目前，章动延迟交替导航激励技术(Delays Alternating with Nutation for Tailored Excitation，DANTE)可以有效抑制动脉血流和脑脊液信号，该技术通过一系列低翻转角脉冲和散相梯度，使静止和运动的物质产生不同信号，具有非常好的运动敏感性，能有效抑制流动信号，但它对流速非常敏感，而脑脊液的速度随位置变化，导致其对韦利斯氏环(Willis环)周围的脑脊液抑制不够均匀、对大脑中动脉M2段周围流速缓慢的脑脊液信号抑制不彻底，从而使得血管壁的外边界无法分辨，容易造成误诊并且不利于人工智能诊断分析。Cardiovascular and cerebrovascular diseases have become the most important diseases that threaten human health, and atherosclerotic plaques are an important risk factor for cardiovascular and cerebrovascular diseases. Therefore, it is important to accurately assess the stability of plaques and identify vulnerable plaques for prevention. Stroke events are significant. Because the intracranial arteries are surrounded by cerebrospinal fluid, in order to clearly distinguish the boundaries of vascular walls of the intracranial arteries and the plaques attached to them, it is necessary to simultaneously suppress arterial blood flow and cerebrospinal fluid signals. At present, nutation delay alternate navigation stimulation technology (Nutation for Tailored Excitation, DANTE) can effectively suppress arterial blood flow and cerebrospinal fluid signals. This technology uses a series of low flip angle pulses and scattered phase gradients to make stationary and moving substances Generates different signals, has very good motion sensitivity, and can effectively suppress flow signals, but it is very sensitive to flow velocity, and the speed of cerebrospinal fluid varies with location, resulting in insufficient inhibition of cerebrospinal fluid around the Willis ring The cerebrospinal fluid signals that are uniform and slow in the flow around the M2 segment of the middle cerebral artery are not completely suppressed, so that the outer boundary of the blood vessel wall cannot be distinguished, which is easy to cause misdiagnosis and is not conducive to artificial intelligence diagnostic analysis.
而基于可变翻转角的快速自旋回波序列因其固有的流动敏感特性可用于血管壁成像，但其运动敏感性有限，难以同时抑制流速差异较大的颅内动脉和颈动脉的血流信号以及流速非常缓慢的脑脊液信号，造成磁共振血管壁图像的组织对比度低，不能突出病灶的显示。However, fast spin echo sequences based on variable flip angles can be used for vascular wall imaging due to their inherent flow sensitivity characteristics, but their motion sensitivity is limited, and it is difficult to simultaneously suppress blood flow signals of intracranial and carotid arteries with large differences in velocity. And the cerebrospinal fluid signal with very slow flow rate causes the tissue contrast of the magnetic resonance blood vessel wall image to be low, which cannot highlight the display of the lesion.
发明内容Summary of the Invention
本发明的目的在于提供一种血管壁成像中脑脊液信号的抑制方法、装置、 设备及存储介质，旨在解决由于现有技术无法提供一种有效的血管壁成像中脑脊液信号的抑制方法，导致磁共振血管壁成像中脑脊液信号的抑制不彻底、血管壁的外边界辨识度低的问题。The purpose of the present invention is to provide a method, device, equipment and storage medium for suppressing cerebrospinal fluid signal in imaging of blood vessel wall, which aims to solve the problem that because of the failure to provide an effective method for suppressing cerebrospinal fluid signal in imaging of blood vessel wall, The problems of incomplete suppression of cerebrospinal fluid signals and low recognition of outer boundaries of blood vessel walls in resonance blood vessel wall imaging.
一方面，本发明提供了一种血管壁成像中脑脊液信号的抑制方法，所述方法包括下述步骤：In one aspect, the present invention provides a method for inhibiting cerebrospinal fluid signals in imaging of blood vessel walls, the method comprising the following steps:
在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量；During the magnetic resonance blood vessel wall imaging, the longitudinal macroscopic magnetization vector obtained in advance is flipped to the XY plane through a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain; a transverse magnetization vector is obtained;
通过所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。The transverse magnetization vector is flipped to a negative Z axis by a third angle inversion pulse in the inversion recovery pulse chain, so as to achieve suppression of a cerebrospinal fluid signal.
另一方面，本发明提供了一种血管壁成像中脑脊液信号的抑制装置，所述装置包括：In another aspect, the present invention provides a cerebrospinal fluid signal suppression device for vascular wall imaging, the device includes:
第一翻转单元，用于在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量；以及A first inversion unit, configured to invert the longitudinal macroscopic magnetization vector obtained in advance to XY through a first inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain during a magnetic resonance vascular wall imaging process A plane to obtain a transverse magnetization vector; and
第二翻转单元，用于通过所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。A second inversion unit is configured to invert the lateral magnetization vector to a negative Z-axis through a third angle inversion pulse in the inversion recovery pulse chain, so as to achieve suppression of a cerebrospinal fluid signal.
另一方面，本发明还提供了一种医疗设备，包括存储器、处理器以及存储在所述存储器中并可在所述处理器上运行的计算机程序，所述处理器执行所述计算机程序时实现如上述血管壁成像中脑脊液信号的抑制方法所述的步骤。In another aspect, the present invention also provides a medical device including a memory, a processor, and a computer program stored in the memory and executable on the processor. The processor is implemented when the processor executes the computer program. The steps as described in the method for suppressing cerebrospinal fluid signal in the above-mentioned vascular wall imaging.
另一方面，本发明还提供了一种计算机可读存储介质，所述计算机可读存储介质存储有计算机程序，所述计算机程序被处理器执行时实现如上述血管壁成像中脑脊液信号的抑制方法所述的步骤。In another aspect, the present invention also provides a computer-readable storage medium that stores a computer program that, when executed by a processor, implements a method for suppressing cerebrospinal fluid signals as described above in vascular wall imaging. Described steps.
本发明在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量，通过反转恢复脉冲链中第三角度反转脉冲将横向磁化 矢量翻转到负Z轴，从而实现脑脊液信号的抑制，提高了磁共振血管壁成像中脑脊液信号的抑制效果，进而提高血管壁图像的组织对比度，利于医生的诊断和定量分析。In the process of magnetic resonance blood vessel wall imaging, the present invention reverses the longitudinal macroscopic magnetization vector obtained in advance to the XY plane through a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain, thereby obtaining a transverse magnetization. Vector, invert the transverse magnetization vector to the negative Z axis by reversing the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal, improving the inhibitory effect of the cerebrospinal fluid signal in magnetic resonance vascular wall imaging, and thereby improving the vascular wall The tissue contrast of the image is conducive to doctor's diagnosis and quantitative analysis.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
图1是本发明实施例一提供的血管壁成像中脑脊液信号的抑制方法的实现流程图；FIG. 1 is a flowchart of implementation of a method for suppressing cerebrospinal fluid signals in vascular wall imaging provided by Embodiment 1 of the present invention; FIG.
图2是本发明实施例二提供的血管壁成像中脑脊液信号的抑制装置的结构示意图；FIG. 2 is a schematic structural diagram of a cerebrospinal fluid signal suppression device in vascular wall imaging provided by Embodiment 2 of the present invention; FIG.
图3是本发明实施例三提供的血管壁成像中脑脊液信号的抑制装置的结构示意图；以及FIG. 3 is a schematic structural diagram of a cerebrospinal fluid signal suppression device for vascular wall imaging provided by Embodiment 3 of the present invention; and
图4是本发明实施例四提供的医疗设备的结构示意图。4 is a schematic structural diagram of a medical device according to a fourth embodiment of the present invention.
具体实施方式detailed description
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.
以下结合具体实施例对本发明的具体实现进行详细描述：The following describes the specific implementation of the present invention in detail with reference to specific embodiments:
实施例一：Embodiment one:
图1示出了本发明实施例一提供的血管壁成像中脑脊液信号的抑制方法的实现流程，为了便于说明，仅示出了与本发明实施例相关的部分，详述如下：FIG. 1 shows the implementation process of the method for suppressing cerebrospinal fluid signals in vascular wall imaging provided in Embodiment 1 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown, and the details are as follows:
在步骤S101中，在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量。In step S101, during the imaging of the magnetic resonance blood vessel wall, the longitudinal macroscopic magnetization vector obtained in advance is flipped to the XY plane by a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain, Obtain the transverse magnetization vector.
本发明实施例适用于医学图像处理平台、系统或设备，例如个人计算机、服务器等。在磁共振血管壁成像过程中，人体进入磁共振系统的主磁场后，通 过发射预设的成像序列(例如，快速自旋回波成像序列或者可变翻转角的快速自旋回波成像序列)回聚脉冲链，人体组织被磁化，产生纵向宏观磁化矢量，再通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将少量恢复的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量。The embodiments of the present invention are applicable to a medical image processing platform, system, or device, such as a personal computer, a server, and the like. During the magnetic resonance blood vessel wall imaging, after the human body enters the main magnetic field of the magnetic resonance system, it returns to focus by transmitting a preset imaging sequence (for example, a fast spin echo imaging sequence or a variable spin angle fast spin echo imaging sequence). In the pulse chain, the human tissue is magnetized to generate a longitudinal macroscopic magnetization vector, and the first angle inversion pulse and the second angle inversion pulse in the pulse chain are restored by a preset inversion to reverse a small amount of the restored longitudinal macromagnetization vector to the XY plane. To obtain the transverse magnetization vector.
在通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面时，优选地，通过施加在Y轴的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，从而提高T1图像的加权比。When the previously obtained longitudinal macroscopic magnetization vector is flipped to the XY plane by the first angle inversion pulse and the second angle inversion pulse in a preset inversion recovery pulse chain, it is preferable to recover by inversion applied on the Y axis The first angle inversion pulse and the second angle inversion pulse in the pulse chain invert the previously obtained longitudinal macroscopic magnetization vector to the XY plane, thereby improving the weighting ratio of the T1 image.
在通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面之前，优选地，获取预先发射的成像序列回聚脉冲链中最后一个回聚脉冲对应的翻转角度，根据该翻转角度和预设的最大翻转角阈值，计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度，根据第一角度对应的第一角度反转脉冲、第二角度对应的第二角度反转脉冲以及预设第三角度对应的第三角度反转脉冲构成反转恢复脉冲链，通过构建不依赖与流速的反转恢复脉冲链，从而提高对颅内流速非常缓慢的脑脊液信号的抑制效果。Before the previously obtained longitudinal macroscopic magnetization vector is flipped to the XY plane by the first angle inversion pulse and the second angle inversion pulse in a preset inversion recovery pulse chain, preferably, a pre-emission imaging sequence refocusing pulse is obtained The inversion angle corresponding to the last refocusing pulse in the chain. Based on the inversion angle and a preset maximum inversion angle threshold, the first and second angle inversion pulses corresponding to the first angle inversion pulse in the inversion recovery pulse chain are calculated. The corresponding second angle, according to the first angle inversion pulse corresponding to the first angle, the second angle inversion pulse corresponding to the second angle, and the third angle inversion pulse corresponding to the preset third angle, constitutes a reverse recovery pulse chain. By constructing a chain of recovery pulses that does not depend on the flow velocity, the effect of suppressing the cerebrospinal fluid signal with very slow intracranial flow velocity is improved.
在计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度时，优选地，根据角度计算公式
Figure PCTCN2019088331-appb-000001
计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度，从而提高血管壁和脑脊液的对比度，进而提高血管壁的外边界的辨识度。其中
Figure PCTCN2019088331-appb-000002
n∈{1,2}，
Figure PCTCN2019088331-appb-000003
为反转恢复脉冲链中的第n个角度，β max为最大翻转角阈值，β max受成像序列回聚脉冲链中射频脉冲的电压峰值和功率沉积限制，
Figure PCTCN2019088331-appb-000004
为获取到的成像序列回聚脉冲链中最后一个回聚脉冲对应的翻转角度。 When calculating the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, preferably, the angle calculation formula is used
Figure PCTCN2019088331-appb-000001
Calculate the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, thereby improving the contrast between the blood vessel wall and the cerebrospinal fluid, and thereby improving the recognition of the outer boundary of the blood vessel wall . among them
Figure PCTCN2019088331-appb-000002
n∈ {1,2},
Figure PCTCN2019088331-appb-000003
In order to reverse the nth angle in the recovery pulse chain, β max is the maximum flip angle threshold, β max is limited by the voltage peak and power deposition of the RF pulse in the imaging sequence refocusing pulse chain
Figure PCTCN2019088331-appb-000004
The reversal angle corresponding to the last refocusing pulse in the refocusing pulse chain of the acquired imaging sequence.
在根据第一角度对应的第一角度反转脉冲、第二角度对应的第二角度反转脉冲以及预设第三角度对应的第三角度反转脉冲构成反转恢复脉冲链之前，优选地，将第三角度反转脉冲对应的第三角度设置为90°，从而提高对颅内流速非常缓慢的脑脊液信号的抑制效果。Before the inversion recovery pulse chain is formed according to the first angle inversion pulse corresponding to the first angle, the second angle inversion pulse corresponding to the second angle, and the third angle inversion pulse corresponding to the preset third angle, preferably, The third angle corresponding to the third angle inversion pulse is set to 90 °, thereby improving the effect of suppressing cerebrospinal fluid signals with very slow intracranial flow velocity.
在步骤S102中，通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。In step S102, the transverse magnetization vector is reversed to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain to achieve suppression of the cerebrospinal fluid signal.
在本发明实施例中，在通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴时，优选地，通过施加在X轴的反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，由于脑脊液信号恢复慢，在进行下一个激发脉冲时脑脊液信号的磁化矢量几乎没有，完成了对脑脊液信号的抑制，从而提高脑脊液信号的抑制效果。In the embodiment of the present invention, when the transverse magnetization vector is flipped to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, preferably, the third angle in the pulse chain is recovered by inverting the X-axis. Inverting the pulse reverses the transverse magnetization vector to the negative Z axis. Due to the slow recovery of the cerebrospinal fluid signal, there is almost no magnetization vector of the cerebrospinal fluid signal when the next excitation pulse is performed, which completes the suppression of the cerebrospinal fluid signal, thereby improving the cerebrospinal fluid signal suppression effect.
在本发明实施例中，在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量，通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，从而实现脑脊液信号的抑制，提高了磁共振血管壁成像中脑脊液信号的抑制效果，进而提高血管壁图像的组织对比度，利于医生的诊断和定量分析。In the embodiment of the present invention, during the imaging of the magnetic resonance blood vessel wall, the longitudinal macroscopic magnetization vector obtained in advance is flipped to XY by a first inversion recovery pulse and a second angle inversion pulse in a preset inversion recovery pulse chain. Plane, obtain the transverse magnetization vector, and invert the transverse magnetization vector to the negative Z axis by inverting the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal and improving the cerebrospinal fluid signal suppression effect in magnetic resonance blood vessel wall imaging In order to improve the tissue contrast of the vascular wall image, it is helpful for the doctor's diagnosis and quantitative analysis.
实施例二：Embodiment two:
图2示出了本发明实施例二提供的血管壁成像中脑脊液信号的抑制装置的结构，为了便于说明，仅示出了与本发明实施例相关的部分，其中包括：FIG. 2 shows the structure of a cerebrospinal fluid signal suppression device for vascular wall imaging provided in Embodiment 2 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown, including:
第一翻转单元21，用于在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量。The first inversion unit 21 is configured to invert the longitudinal macromagnetization vector obtained in advance to a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain during a magnetic resonance vascular wall imaging process. XY plane, obtain the transverse magnetization vector.
本发明实施例适用于医学图像处理平台、系统或设备，例如个人计算机、服务器等。在磁共振血管壁成像过程中，人体进入磁共振系统的主磁场后，通过发射预设的成像序列(例如，快速自旋回波成像序列或者可变翻转角的快速 自旋回波成像序列)回聚脉冲链，人体组织被磁化，产生纵向宏观磁化矢量，再通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将少量恢复的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量。The embodiments of the present invention are applicable to a medical image processing platform, system, or device, such as a personal computer, a server, and the like. During the magnetic resonance blood vessel wall imaging, after the human body enters the main magnetic field of the magnetic resonance system, it returns to focus by transmitting a preset imaging sequence (for example, a fast spin echo imaging sequence or a variable spin angle fast spin echo imaging sequence). In the pulse chain, the human tissue is magnetized to generate a longitudinal macroscopic magnetization vector, and the first angle inversion pulse and the second angle inversion pulse in the pulse chain are restored by a preset inversion to reverse a small amount of the restored longitudinal macromagnetization vector to the XY plane. To obtain the transverse magnetization vector.
在通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面时，优选地，通过施加在Y轴的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，从而提高T1图像的加权比。When the previously obtained longitudinal macroscopic magnetization vector is flipped to the XY plane by the first angle inversion pulse and the second angle inversion pulse in a preset inversion recovery pulse chain, it is preferable to recover by inversion applied on the Y axis The first angle inversion pulse and the second angle inversion pulse in the pulse chain invert the previously obtained longitudinal macroscopic magnetization vector to the XY plane, thereby improving the weighting ratio of the T1 image.
第二翻转单元22，用于通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。The second inverting unit 22 is configured to invert the lateral magnetization vector to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, so as to suppress the cerebrospinal fluid signal.
在本发明实施例中，在通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴时，优选地，通过施加在X轴的反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，由于脑脊液信号恢复慢，在进行下一个激发脉冲时脑脊液信号的磁化矢量几乎没有，完成了对脑脊液信号的抑制，从而提高脑脊液信号的抑制效果。In the embodiment of the present invention, when the transverse magnetization vector is flipped to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, preferably, the third angle in the pulse chain is recovered by inverting the X-axis. Inverting the pulse reverses the transverse magnetization vector to the negative Z axis. Due to the slow recovery of the cerebrospinal fluid signal, there is almost no magnetization vector of the cerebrospinal fluid signal when the next excitation pulse is performed, which completes the suppression of the cerebrospinal fluid signal, thereby improving the effect of suppressing the cerebrospinal fluid signal.
在本发明实施例中，血管壁成像中脑脊液信号的抑制装置的各单元可由相应的硬件或软件单元实现，各单元可以为独立的软、硬件单元，也可以集成为一个软、硬件单元，在此不用以限制本发明。In the embodiment of the present invention, each unit of the cerebrospinal fluid signal suppression device in vascular wall imaging may be implemented by corresponding hardware or software units. Each unit may be an independent software and hardware unit, or may be integrated into one software and hardware unit. This is not intended to limit the invention.
实施例三：Embodiment three:
图3示出了本发明实施例三提供的血管壁成像中脑脊液信号的抑制装置的结构，为了便于说明，仅示出了与本发明实施例相关的部分，其中包括：FIG. 3 shows a structure of a cerebrospinal fluid signal suppression device in vascular wall imaging provided in Embodiment 3 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown, including:
翻转角度获取单元31，用于在磁共振血管壁成像过程中，获取预先发射的成像序列回聚脉冲链中最后一个回聚脉冲对应的翻转角度。A flip angle acquisition unit 31 is configured to obtain a flip angle corresponding to the last refocusing pulse in the refocusing pulse chain of the imaging sequence emitted in advance during the imaging of the magnetic resonance blood vessel wall.
本发明实施例适用于医学图像处理平台、系统或设备，例如个人计算机、服务器等。磁共振血管壁成像是通过发射快速自旋回波成像序列或者可变翻转角的快速自旋回波成像序列，产生回波信号，再根据产生的回波信号生成磁共振血管壁图像。在磁共振血管壁成像过程中，获取成像序列回聚脉冲链中最后 一个回聚脉冲对应的翻转角度。The embodiments of the present invention are applicable to a medical image processing platform, system, or device, such as a personal computer, a server, and the like. Magnetic resonance blood vessel wall imaging is to generate an echo signal by transmitting a fast spin echo imaging sequence or a fast spin echo imaging sequence with a variable flip angle, and then generate a magnetic resonance blood vessel wall image based on the generated echo signal. During the magnetic resonance vascular wall imaging, the flip angle corresponding to the last refocusing pulse in the refocusing pulse chain of the imaging sequence is obtained.
角度计算单元32，用于根据翻转角度和预设的最大翻转角阈值，计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度。The angle calculation unit 32 is configured to calculate a first angle corresponding to a first angle inversion pulse and a second angle corresponding to a second angle inversion pulse in the inversion recovery pulse chain according to the inversion angle and a preset maximum inversion angle threshold.
在本发明实施例中，在计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度时，优选地，根据角度计算公式
Figure PCTCN2019088331-appb-000005
计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度，从而提高血管壁和脑脊液的对比度，进而提高血管壁的外边界的辨识度。其中
Figure PCTCN2019088331-appb-000006
n∈{1,2}，
Figure PCTCN2019088331-appb-000007
为反转恢复脉冲链中的第n个角度，β max为最大翻转角阈值，β max受成像序列回聚脉冲链中射频脉冲的电压峰值和功率沉积限制，
Figure PCTCN2019088331-appb-000008
为获取到的成像序列回聚脉冲链中最后一个回聚脉冲对应的翻转角度。 In the embodiment of the present invention, when calculating the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, preferably, an angle calculation formula is used
Figure PCTCN2019088331-appb-000005
Calculate the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, thereby improving the contrast between the blood vessel wall and the cerebrospinal fluid, and thereby improving the recognition of the outer boundary of the blood vessel wall . among them
Figure PCTCN2019088331-appb-000006
n∈ {1,2},
Figure PCTCN2019088331-appb-000007
In order to reverse the nth angle in the recovery pulse chain, β max is the maximum flip angle threshold, β max is limited by the voltage peak and power deposition of the RF pulse in the imaging sequence refocusing pulse chain
Figure PCTCN2019088331-appb-000008
The reversal angle corresponding to the last refocusing pulse in the refocusing pulse chain of the acquired imaging sequence.
脉冲链构成单元33，用于根据第一角度对应的第一角度反转脉冲、第二角度对应的第二角度反转脉冲以及预设第三角度对应的第三角度反转脉冲构成反转恢复脉冲链。The pulse chain constituting unit 33 is configured to form a reverse recovery according to a first angle inversion pulse corresponding to a first angle, a second angle inversion pulse corresponding to a second angle, and a third angle inversion pulse corresponding to a preset third angle. Pulse chain.
在本发明实施例中，在根据第一角度对应的第一角度反转脉冲、第二角度对应的第二角度反转脉冲以及预设第三角度对应的第三角度反转脉冲构成反转恢复脉冲链之前，优选地，将第三角度反转脉冲对应的第三角度设置为90°，从而提高对颅内流速非常缓慢的脑脊液信号的抑制效果。In the embodiment of the present invention, inversion recovery is constituted by a first angle inversion pulse corresponding to a first angle, a second angle inversion pulse corresponding to a second angle, and a third angle inversion pulse corresponding to a preset third angle. Prior to the pulse chain, preferably, the third angle corresponding to the third angle inversion pulse is set to 90 °, so as to improve the effect of suppressing cerebrospinal fluid signals with very slow intracranial flow velocity.
第一翻转单元34，用于在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量。The first inversion unit 34 is configured to invert the longitudinal macromagnetization vector obtained in advance to the first angle inversion pulse and the second angle inversion pulse in a preset inversion recovery pulse chain during the magnetic resonance blood vessel wall imaging. XY plane, obtain the transverse magnetization vector.
在本发明实施例中，在磁共振血管壁成像过程中，人体进入磁共振系统的主磁场后，人体组织被磁化，产生纵向宏观磁化矢量，再通过预设的反转恢复 脉冲链中第一角度反转脉冲和第二角度反转脉冲将少量恢复的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量。In the embodiment of the present invention, during the imaging of the magnetic resonance blood vessel wall, after the human body enters the main magnetic field of the magnetic resonance system, the human tissue is magnetized to generate a longitudinal macroscopic magnetization vector, and the first in the pulse chain is restored by a preset inversion. The angle inversion pulse and the second angle inversion pulse flip a small amount of recovered longitudinal macroscopic magnetization vectors to the XY plane to obtain a transverse magnetization vector.
在通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面时，优选地，通过施加在Y轴的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，从而提高T1图像的加权比。When the previously obtained longitudinal macroscopic magnetization vector is flipped to the XY plane by the first angle inversion pulse and the second angle inversion pulse in a preset inversion recovery pulse chain, it is preferable to recover by inversion applied on the Y axis The first angle inversion pulse and the second angle inversion pulse in the pulse chain invert the previously obtained longitudinal macroscopic magnetization vector to the XY plane, thereby improving the weighting ratio of the T1 image.
第二翻转单元35，用于通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。The second inversion unit 35 is configured to invert the transverse magnetization vector to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, so as to suppress the cerebrospinal fluid signal.
在本发明实施例中，在通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴时，优选地，通过施加在X轴的反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，由于脑脊液信号恢复慢，在进行下一个激发脉冲时脑脊液信号的磁化矢量几乎没有，完成了对脑脊液信号的抑制，从而提高脑脊液信号的抑制效果。In the embodiment of the present invention, when the transverse magnetization vector is flipped to the negative Z-axis by inverting the third angle inversion pulse in the recovery pulse chain, preferably, the third angle in the pulse chain is recovered by inverting the X-axis. Inverting the pulse reverses the transverse magnetization vector to the negative Z axis. Due to the slow recovery of the cerebrospinal fluid signal, there is almost no magnetization vector of the cerebrospinal fluid signal when the next excitation pulse is performed, which completes the suppression of the cerebrospinal fluid signal, thereby improving the effect of suppressing the cerebrospinal fluid signal.
因此，优选地，角度计算单元32包括：Therefore, preferably, the angle calculation unit 32 includes:
角度计算子单元321，用于根据角度计算公式
Figure PCTCN2019088331-appb-000009
计算反转恢复脉冲链中第一角度反转脉冲对应的第一角度和第二角度反转脉冲对应的第二角度，其中
Figure PCTCN2019088331-appb-000010
n∈{1,2}，
Figure PCTCN2019088331-appb-000011
为反转恢复脉冲链中的第n个角度，β max为最大翻转角阈值，
Figure PCTCN2019088331-appb-000012
为翻转角度。 Angle calculation subunit 321, for calculating formulas based on angles
Figure PCTCN2019088331-appb-000009
Calculate the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, where
Figure PCTCN2019088331-appb-000010
n∈ {1,2},
Figure PCTCN2019088331-appb-000011
To invert the nth angle in the recovery pulse chain, β max is the maximum flip angle threshold,
Figure PCTCN2019088331-appb-000012
Is the flip angle.
第二翻转单元35包括：The second turning unit 35 includes:
第二翻转子单元351，用于通过施加在X轴的反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴。The second inversion subunit 351 is configured to invert the transverse magnetization vector to the negative Z-axis by applying a third angle inversion pulse in the inversion recovery pulse chain of the X-axis.
在本发明实施例中，血管壁成像中脑脊液信号的抑制装置的各单元可由相应的硬件或软件单元实现，各单元可以为独立的软、硬件单元，也可以集成为一个软、硬件单元，在此不用以限制本发明。In the embodiment of the present invention, each unit of the cerebrospinal fluid signal suppression device in vascular wall imaging may be implemented by corresponding hardware or software units. Each unit may be an independent software and hardware unit, or may be integrated into one software and hardware unit. This is not intended to limit the invention.
实施例四：Embodiment 4:
图4示出了本发明实施例四提供的医疗设备的结构，为了便于说明，仅示出了与本发明实施例相关的部分。FIG. 4 shows a structure of a medical device provided in Embodiment 4 of the present invention. For convenience of explanation, only parts related to the embodiment of the present invention are shown.
本发明实施例的医疗设备4包括处理器40、存储器41以及存储在存储器41中并可在处理器40上运行的计算机程序42。该处理器40执行计算机程序42时实现上述血管壁成像中脑脊液信号的抑制方法实施例中的步骤，例如图1所示的步骤S101至S102。或者，处理器40执行计算机程序42时实现上述各装置实施例中各单元的功能，例如图2所示单元21至22的功能。The medical device 4 according to the embodiment of the present invention includes a processor 40, a memory 41, and a computer program 42 stored in the memory 41 and executable on the processor 40. When the processor 40 executes the computer program 42, the steps in the embodiment of the method for suppressing cerebrospinal fluid signals in the above-mentioned vascular wall imaging are implemented, for example, steps S101 to S102 shown in FIG. 1. Alternatively, when the processor 40 executes the computer program 42, the functions of the units in the foregoing device embodiments are realized, for example, the functions of the units 21 to 22 shown in FIG. 2.
在本发明实施例中，在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量，通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，从而实现脑脊液信号的抑制，提高了磁共振血管壁成像中脑脊液信号的抑制效果，进而提高血管壁图像的组织对比度，利于医生的诊断和定量分析。In the embodiment of the present invention, during the imaging of the magnetic resonance blood vessel wall, the longitudinal macroscopic magnetization vector obtained in advance is flipped to XY by a first inversion recovery pulse and a second angle inversion pulse in a preset inversion recovery pulse chain. Plane, obtain the transverse magnetization vector, and invert the transverse magnetization vector to the negative Z axis by inverting the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal and improving the cerebrospinal fluid signal suppression effect in magnetic resonance blood vessel wall imaging In order to improve the tissue contrast of the vascular wall image, it is helpful for the doctor's diagnosis and quantitative analysis.
本发明实施例的医疗设备可以为个人计算机、服务器。该医疗设备4中处理器40执行计算机程序42时实现血管壁成像中脑脊液信号的抑制方法时实现的步骤可参考前述方法实施例的描述，在此不再赘述。The medical equipment in the embodiment of the present invention may be a personal computer or a server. For the steps implemented when the processor 40 in the medical device 4 executes the computer program 42 to implement the method for suppressing cerebrospinal fluid signals in blood vessel wall imaging, reference may be made to the description of the foregoing method embodiments, and details are not described herein again.
实施例五：Embodiment 5:
在本发明实施例中，提供了一种计算机可读存储介质，该计算机可读存储介质存储有计算机程序，该计算机程序被处理器执行时实现上述血管壁成像中脑脊液信号的抑制方法实施例中的步骤，例如，图1所示的步骤S101至S102。或者，该计算机程序被处理器执行时实现上述各装置实施例中各单元的功能，例如图2所示单元21至22的功能。In the embodiment of the present invention, a computer-readable storage medium is provided. The computer-readable storage medium stores a computer program. When the computer program is executed by a processor, the method for suppressing cerebrospinal fluid signals in the above-mentioned vascular wall imaging is described. The steps are, for example, steps S101 to S102 shown in FIG. 1. Alternatively, when the computer program is executed by a processor, the functions of the units in the foregoing device embodiments are implemented, for example, the functions of the units 21 to 22 shown in FIG. 2.
在本发明实施例中，在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量，通过反转恢复脉冲链中第三角度反转脉冲将横向磁化矢量翻转到负Z轴，从而实现脑脊液信号的抑制，提高了磁共振 血管壁成像中脑脊液信号的抑制效果，进而提高血管壁图像的组织对比度，利于医生的诊断和定量分析。In the embodiment of the present invention, during the imaging of the magnetic resonance blood vessel wall, the longitudinal macroscopic magnetization vector obtained in advance is flipped to XY by a first inversion recovery pulse and a second angle inversion pulse in a preset inversion recovery pulse chain. Plane, obtain the transverse magnetization vector, and invert the transverse magnetization vector to the negative Z axis by inverting the third angle inversion pulse in the recovery pulse chain, thereby suppressing the cerebrospinal fluid signal and improving the cerebrospinal fluid signal suppression effect in magnetic resonance blood vessel wall imaging In order to improve the tissue contrast of the vascular wall image, it is helpful for the doctor's diagnosis and quantitative analysis.
本发明实施例的计算机可读存储介质可以包括能够携带计算机程序代码的任何实体或装置、记录介质，例如，ROM/RAM、磁盘、光盘、闪存等存储器。The computer-readable storage medium of the embodiment of the present invention may include any entity or device capable of carrying computer program code, a recording medium, for example, a memory such as a ROM / RAM, a magnetic disk, an optical disk, a flash memory, or the like.
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。The above description is only the preferred embodiments of the present invention, and is not intended to limit the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention shall be included in the protection of the present invention. Within range.

Claims (10)

  1. 一种血管壁成像中脑脊液信号的抑制方法，其特征在于，所述方法包括下述步骤：A method for suppressing cerebrospinal fluid signal in imaging of blood vessel wall, characterized in that the method includes the following steps:
    在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量；During the magnetic resonance blood vessel wall imaging, the longitudinal macroscopic magnetization vector obtained in advance is flipped to the XY plane through a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain; a transverse magnetization vector is obtained;
    通过所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。The transverse magnetization vector is flipped to a negative Z axis by a third angle inversion pulse in the inversion recovery pulse chain, so as to achieve suppression of a cerebrospinal fluid signal.
  2. 如权利要求1所述的方法，其特征在于，在通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将纵向宏观磁化矢量翻转到XY平面之前，所述方法还包括：The method according to claim 1, wherein before the longitudinal macroscopic magnetization vector is flipped to the XY plane by a first angle inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain, the method The method also includes:
    在磁共振血管壁成像过程中，获取预先发射的成像序列回聚脉冲链中最后一个回聚脉冲对应的翻转角度；During the magnetic resonance blood vessel wall imaging, obtain the flip angle corresponding to the last refocusing pulse in the refocusing pulse chain of the imaging sequence emitted in advance;
    根据所述翻转角度和预设的最大翻转角阈值，计算所述反转恢复脉冲链中所述第一角度反转脉冲对应的第一角度和所述第二角度反转脉冲对应的第二角度；Calculating a first angle corresponding to the first angle inversion pulse and a second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain according to the inversion angle and a preset maximum inversion angle threshold ;
    根据所述第一角度对应的所述第一角度反转脉冲、所述第二角度对应的所述第二角度反转脉冲以及预设第三角度对应的第三角度反转脉冲构成所述反转恢复脉冲链。The inversion is formed according to the first angle inversion pulse corresponding to the first angle, the second angle inversion pulse corresponding to the second angle, and a third angle inversion pulse corresponding to a preset third angle. Turn to recover the pulse chain.
  3. 如权利要求2所述的方法，其特征在于，计算所述反转恢复脉冲链中所述第一角度反转脉冲对应的第一角度和所述第二角度反转脉冲对应的第二角度的步骤，包括：The method according to claim 2, characterized in that calculating the first angle corresponding to the first angle inversion pulse and the second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain Steps, including:
    根据角度计算公式
    Figure PCTCN2019088331-appb-100001
    计算所述反转恢复脉冲链中所述第一角度反转脉冲对应的第一角度和所述第二角度反转脉冲对应的第二角 度，其中
    Figure PCTCN2019088331-appb-100002
    n∈{1,2}，
    Figure PCTCN2019088331-appb-100003
    为所述反转恢复脉冲链中的第n个角度，β max为所述最大翻转角阈值，
    Figure PCTCN2019088331-appb-100004
    为所述翻转角度。     Calculation formula based on angle
    Figure PCTCN2019088331-appb-100001
    Calculating a first angle corresponding to the first angle inversion pulse and a second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, wherein
    Figure PCTCN2019088331-appb-100002
    n∈ {1,2},
    Figure PCTCN2019088331-appb-100003
    Is the n-th angle in the reverse recovery pulse chain, β max is the maximum flip angle threshold,
    Figure PCTCN2019088331-appb-100004
    Is the flip angle.
  4. 如权利要求1所述的方法，其特征在于，通过所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴的步骤，包括：The method according to claim 1, wherein the step of inverting the transverse magnetization vector to a negative Z axis by a third angle inversion pulse in the inversion recovery pulse chain comprises:
    通过施加在X轴的所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴。The transverse magnetization vector is inverted to the negative Z-axis by a third angle inversion pulse in the inversion-recovery pulse train applied on the X-axis.
  5. 一种血管壁成像中脑脊液信号的抑制装置，其特征在于，所述装置包括：A device for suppressing cerebrospinal fluid signals in vascular wall imaging, characterized in that the device includes:
    第一翻转单元，用于在磁共振血管壁成像过程中，通过预设的反转恢复脉冲链中第一角度反转脉冲和第二角度反转脉冲将预先获得的纵向宏观磁化矢量翻转到XY平面，获得横向磁化矢量；以及A first inversion unit, configured to invert the longitudinal macroscopic magnetization vector obtained in advance to XY through a first inversion pulse and a second angle inversion pulse in a preset inversion recovery pulse chain during a magnetic resonance vascular wall imaging process A plane to obtain a transverse magnetization vector; and
    第二翻转单元，用于通过所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴，以实现对脑脊液信号的抑制。A second inversion unit is configured to invert the lateral magnetization vector to a negative Z-axis through a third angle inversion pulse in the inversion recovery pulse chain, so as to achieve suppression of a cerebrospinal fluid signal.
  6. 如权利要求5所述的装置，其特征在于，所述装置还包括：The apparatus according to claim 5, further comprising:
    翻转角度获取单元，用于在磁共振血管壁成像过程中，获取预先发射的成像序列回聚脉冲链中最后一个回聚脉冲对应的翻转角度；A flip angle acquisition unit, configured to obtain a flip angle corresponding to the last refocusing pulse in the refocusing pulse chain of the imaging sequence emitted in advance during the imaging of the magnetic resonance blood vessel wall;
    角度计算单元，用于根据所述翻转角度和预设的最大翻转角阈值，计算所述反转恢复脉冲链中所述第一角度反转脉冲对应的第一角度和所述第二角度反转脉冲对应的第二角度；以及An angle calculation unit, configured to calculate a first angle and a second angle inversion corresponding to the first angle inversion pulse in the inversion recovery pulse chain according to the inversion angle and a preset maximum inversion angle threshold The second angle corresponding to the pulse; and
    脉冲链构成单元，用于根据所述第一角度对应的所述第一角度反转脉冲、所述第二角度对应的所述第二角度反转脉冲以及预设第三角度对应的第三角度反转脉冲构成所述反转恢复脉冲链。A pulse chain constituting unit configured to invert the first angle pulse corresponding to the first angle, the second angle inversion pulse corresponding to the second angle, and a third angle corresponding to a preset third angle The inversion pulse constitutes the inversion recovery pulse chain.
  7. 如权利要求6所述的装置，其特征在于，所述角度计算单元包括：The apparatus according to claim 6, wherein the angle calculation unit comprises:
    角度计算子单元，用于根据角度计算公式
    Figure PCTCN2019088331-appb-100005
    计算所述反转恢复脉冲链中所述第一角度反转脉冲对应的第一角度和所述第二角度反转 脉冲对应的第二角度，其中
    Figure PCTCN2019088331-appb-100006
    n∈{1,2}，
    Figure PCTCN2019088331-appb-100007
    为所述反转恢复脉冲链中的第n个角度，β max为所述最大翻转角阈值，
    Figure PCTCN2019088331-appb-100008
    为所述翻转角度。     Angle calculation subunit for calculating formulas based on angles
    Figure PCTCN2019088331-appb-100005
    Calculating a first angle corresponding to the first angle inversion pulse and a second angle corresponding to the second angle inversion pulse in the inversion recovery pulse chain, wherein
    Figure PCTCN2019088331-appb-100006
    n∈ {1,2},
    Figure PCTCN2019088331-appb-100007
    Is the n-th angle in the reverse recovery pulse chain, β max is the maximum flip angle threshold,
    Figure PCTCN2019088331-appb-100008
    Is the flip angle.
  8. 如权利要求5所述的装置，其特征在于，所述第二翻转单元还包括：The apparatus according to claim 5, wherein the second turning unit further comprises:
    第二翻转子单元，用于通过施加在X轴的所述反转恢复脉冲链中第三角度反转脉冲将所述横向磁化矢量翻转到负Z轴。A second inversion sub-unit is used to invert the transverse magnetization vector to a negative Z-axis by a third angle inversion pulse applied in the inversion recovery pulse chain of the X-axis.
  9. 一种医疗设备，包括存储器、处理器以及存储在所述存储器中并可在所述处理器上运行的计算机程序，其特征在于，所述处理器执行所述计算机程序时实现如权利要求1至4任一项所述方法的步骤。A medical device includes a memory, a processor, and a computer program stored in the memory and executable on the processor, characterized in that when the processor executes the computer program, the processor implements claims 1 to Steps of the method of any one of 4.
  10. 一种计算机可读存储介质，所述计算机可读存储介质存储有计算机程序，其特征在于，所述计算机程序被处理器执行时实现如权利要求1至4任一项所述方法的步骤。A computer-readable storage medium storing a computer program, wherein when the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 4 are implemented.
PCT/CN2019/088331 2018-07-23 2019-05-24 Method and apparatus for inhibiting cerebrospinal fluid signal in vascular wall imaging, and device and medium WO2020019852A1 (en)

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