WO2020014469A1 - Compositions et procédés pour le traitement d'infections bactériennes - Google Patents
Compositions et procédés pour le traitement d'infections bactériennes Download PDFInfo
- Publication number
- WO2020014469A1 WO2020014469A1 PCT/US2019/041383 US2019041383W WO2020014469A1 WO 2020014469 A1 WO2020014469 A1 WO 2020014469A1 US 2019041383 W US2019041383 W US 2019041383W WO 2020014469 A1 WO2020014469 A1 WO 2020014469A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- compound
- independently
- alkyl
- pharmaceutically acceptable
- Prior art date
Links
- 0 CC(C)C[C@@]1NC([C@@](*)NC([C@](CCN)NC([C@](CCNC([C@]2NC([C@](CCN)N3)=*[C@@]2C)=O)N(*)C(C(*)NINNC(NC(*)C(N(*)[C@@](CCNC([C@]([C@@](C)O)NC([C@](CCN)NC([C@](CCN)NC2=*=C([C@@](*)NC([C@](CCN)N4)=O)N[C@@]2CC(C)C)=O)=O)=O)C4=O)=O)=O)=O)=O)=O)=*=C1N[C@@](CCN)C3=O Chemical compound CC(C)C[C@@]1NC([C@@](*)NC([C@](CCN)NC([C@](CCNC([C@]2NC([C@](CCN)N3)=*[C@@]2C)=O)N(*)C(C(*)NINNC(NC(*)C(N(*)[C@@](CCNC([C@]([C@@](C)O)NC([C@](CCN)NC([C@](CCN)NC2=*=C([C@@](*)NC([C@](CCN)N4)=O)N[C@@]2CC(C)C)=O)=O)=O)C4=O)=O)=O)=O)=O)=O)=*=C1N[C@@](CCN)C3=O 0.000 description 32
- NIDNOXCRFUCAKQ-UHFFFAOYSA-N OC(C(C1C=CC2C1)C2C(O)=O)=O Chemical compound OC(C(C1C=CC2C1)C2C(O)=O)=O NIDNOXCRFUCAKQ-UHFFFAOYSA-N 0.000 description 2
- UEXCJVNBTNXOEH-UHFFFAOYSA-N C#Cc1ccccc1 Chemical compound C#Cc1ccccc1 UEXCJVNBTNXOEH-UHFFFAOYSA-N 0.000 description 1
- XRZDXDWKVYCJBR-LAURYZNVSA-N CC(C)C[C@H](CN[NH+]([C@H](CN(C1)C(OC(C)(C)C)=O)[C@@H]1C(NC(CC(C)C)C(OC)=O)=O)[O-])C(OC)=O Chemical compound CC(C)C[C@H](CN[NH+]([C@H](CN(C1)C(OC(C)(C)C)=O)[C@@H]1C(NC(CC(C)C)C(OC)=O)=O)[O-])C(OC)=O XRZDXDWKVYCJBR-LAURYZNVSA-N 0.000 description 1
- PQHKDPZFTZJOSR-WNDOAUFQSA-N CCCC[C@@H](C(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@H](CO)C(N[C@H](C)CCNC([C@H]([C@@H](C)O)NC([C@H](CCN)NC([C@H](CCN)NC([C@H](CC(C)C)NC([C@@H](Cc1ccccc1)NC([C@H](CCN)N=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNCC(N[C@@H](CCCC)C(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@H](CO)C(N[C@@H](CCNC([C@H]([C@@H](C)O)NC([C@H](CC)N[C@H](CCN)NC([C@H](CC(C)C)N)=O)=O)=O)C(N[C@@H](CCN)C(N[C@H](Cc1ccccc1)C=O)=O)=O)=O)=O)=O)=O)=O)=O Chemical compound CCCC[C@@H](C(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@H](CO)C(N[C@H](C)CCNC([C@H]([C@@H](C)O)NC([C@H](CCN)NC([C@H](CCN)NC([C@H](CC(C)C)NC([C@@H](Cc1ccccc1)NC([C@H](CCN)N=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNCC(N[C@@H](CCCC)C(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@H](CO)C(N[C@@H](CCNC([C@H]([C@@H](C)O)NC([C@H](CC)N[C@H](CCN)NC([C@H](CC(C)C)N)=O)=O)=O)C(N[C@@H](CCN)C(N[C@H](Cc1ccccc1)C=O)=O)=O)=O)=O)=O)=O)=O)=O PQHKDPZFTZJOSR-WNDOAUFQSA-N 0.000 description 1
- PJDHHRXYOBMBKB-KBXIAJHMSA-N CCCC[C@@H](C(O)=O)NC([C@H](CCC1)[C@@H]1C(N[C@@H](CCCC)C(O)=O)=O)=O Chemical compound CCCC[C@@H](C(O)=O)NC([C@H](CCC1)[C@@H]1C(N[C@@H](CCCC)C(O)=O)=O)=O PJDHHRXYOBMBKB-KBXIAJHMSA-N 0.000 description 1
- YNZUUXAFXVBGNZ-MNOVXSKESA-N CC[C@H]([C@@H](C(O)=O)NC(OCc1ccccc1)=O)O Chemical compound CC[C@H]([C@@H](C(O)=O)NC(OCc1ccccc1)=O)O YNZUUXAFXVBGNZ-MNOVXSKESA-N 0.000 description 1
- ZWZCMHYDUKQVTR-ZETCQYMHSA-N C[C@@H](CCNC(OC(C)(C)C)=O)C(N)=O Chemical compound C[C@@H](CCNC(OC(C)(C)C)=O)C(N)=O ZWZCMHYDUKQVTR-ZETCQYMHSA-N 0.000 description 1
- CIZXNRGXMYIZGF-SBMCZXAASA-N C[C@H](C(/C=N/C([C@H](CCNC(OC(C)(C)C)=O)NOC(c1ccccc1)=O)=O)C(N[C@@H](CCNC(OC(C)(C)C)=O)C(OC)=O)=O)O Chemical compound C[C@H](C(/C=N/C([C@H](CCNC(OC(C)(C)C)=O)NOC(c1ccccc1)=O)=O)C(N[C@@H](CCNC(OC(C)(C)C)=O)C(OC)=O)=O)O CIZXNRGXMYIZGF-SBMCZXAASA-N 0.000 description 1
- UBJJXCXYPZTDQA-UTLUCORTSA-N C[C@H]([C@@H](C(N[C@@H](CCNC(OC(C)(C)C)=O)C(OC)=O)=O)N)O Chemical compound C[C@H]([C@@H](C(N[C@@H](CCNC(OC(C)(C)C)=O)C(OC)=O)=O)N)O UBJJXCXYPZTDQA-UTLUCORTSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- ILUAAIDVFMVTAU-WDSKDSINSA-N OC([C@@H](CC=CC1)[C@H]1C(O)=O)=O Chemical compound OC([C@@H](CC=CC1)[C@H]1C(O)=O)=O ILUAAIDVFMVTAU-WDSKDSINSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des compositions et des procédés pour le traitement d'infections bactériennes comprenant des composés contenant des dimères d'heptapeptides cycliques. En particulier, des composés peuvent être utilisés dans le traitement d'infections bactériennes provoquées par des bactéries à Gram négatif.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696787P | 2018-07-11 | 2018-07-11 | |
| US62/696,787 | 2018-07-11 | ||
| US201862725086P | 2018-08-30 | 2018-08-30 | |
| US62/725,086 | 2018-08-30 | ||
| US201862778005P | 2018-12-11 | 2018-12-11 | |
| US62/778,005 | 2018-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2020014469A1 true WO2020014469A1 (fr) | 2020-01-16 |
Family
ID=69142792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2019/041383 WO2020014469A1 (fr) | 2018-07-11 | 2019-07-11 | Compositions et procédés pour le traitement d'infections bactériennes |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2020014469A1 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380356B1 (en) * | 1999-12-07 | 2002-04-30 | Advanced Medicine, Inc. | Multivalent polymyxin antibiotics |
| WO2017218922A2 (fr) * | 2016-06-17 | 2017-12-21 | Cidara Therapeutics, Inc. | Composés et méthodes pour le traitement d'infections bactériennes |
-
2019
- 2019-07-11 WO PCT/US2019/041383 patent/WO2020014469A1/fr active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380356B1 (en) * | 1999-12-07 | 2002-04-30 | Advanced Medicine, Inc. | Multivalent polymyxin antibiotics |
| WO2017218922A2 (fr) * | 2016-06-17 | 2017-12-21 | Cidara Therapeutics, Inc. | Composés et méthodes pour le traitement d'infections bactériennes |
Non-Patent Citations (1)
| Title |
|---|
| CHINGLE ET AL.: "Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications", ACCOUNTS OF CHEMICAL RESEARCH, vol. 50, 9 June 2017 (2017-06-09), pages 1541 - 1556, XP055569058 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2017218922A2 (fr) | Composés et méthodes pour le traitement d'infections bactériennes | |
| US10392422B2 (en) | Macrocyclic broad spectrum antibiotics | |
| US20230190950A1 (en) | Compositions and methods for the treatment of bacterial infections | |
| WO2018006063A1 (fr) | Composés et méthodes pour le traitement d'infections bactériennes | |
| US11639343B2 (en) | Compounds targeting and degrading BCR-ABL protein and its antitumor application | |
| Leonhardt et al. | Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors | |
| CZ290445B6 (cs) | Urethany a močoviny, způsoby jejich přípravy a farmaceutické přípravky na jejich bázi | |
| WO2020014501A1 (fr) | Compositions et procédés pour le traitement d'infections bactériennes | |
| WO2013106646A2 (fr) | Composés et procédés pour l'inhibition de l'ubiquitine ligase vcb e3 | |
| KR19980703151A (ko) | 락탐-함유 히드록삼산 유도체, 그의 제조 그리고 매트릭스 메탈로프로테아제의 억제제로서의 그의 용도 | |
| WO2004076478A1 (fr) | Derives peptidiques a activite inhibitrice de la $g(b)secretase | |
| US7238774B2 (en) | Statine derivatives for the treatment of Alzheimer's disease III | |
| WO2015035102A2 (fr) | Compositions et méthodes pour le traitement d'infections fongiques | |
| US20060160747A1 (en) | Statine derivatives for the treatment of Alzheimer's disease II | |
| WO2015164289A1 (fr) | Compositions et méthodes de traitement d'infections fongiques | |
| WO2019126341A2 (fr) | Compositions et procédés pour le traitement d'infections bactériennes | |
| WO2019126353A2 (fr) | Compositions et procédés pour le traitement d'infections bactériennes | |
| JP2018536696A (ja) | ７−オキソ−６−（スルホオキシ）−１，６−ジアザビシクロ［３．２．１］オクタン−２−カルボキサミド含有化合物および細菌感染症の治療におけるそれらの使用 | |
| US10421778B2 (en) | Isoform-selective lysine deacetylase inhibitors | |
| WO2020014469A1 (fr) | Compositions et procédés pour le traitement d'infections bactériennes | |
| US6482921B1 (en) | Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use | |
| OA12164A (en) | Protease inhibitors and their pharmaceutical uses. | |
| US7772221B2 (en) | Diaminopropane derived macrocycles as inhibitors of β amyloid production | |
| US7405201B2 (en) | Antibacterial macrocycles | |
| US20040082664A1 (en) | Derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 19833526 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 19833526 Country of ref document: EP Kind code of ref document: A1 |