WO2019225948A1 - Timbre pour l'atténuation et la prévention de l'acné - Google Patents

Timbre pour l'atténuation et la prévention de l'acné Download PDF

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Publication number
WO2019225948A1
WO2019225948A1 PCT/KR2019/006068 KR2019006068W WO2019225948A1 WO 2019225948 A1 WO2019225948 A1 WO 2019225948A1 KR 2019006068 W KR2019006068 W KR 2019006068W WO 2019225948 A1 WO2019225948 A1 WO 2019225948A1
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Prior art keywords
acne
patch
metal
prevention
biodegradable metal
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PCT/KR2019/006068
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English (en)
Korean (ko)
Inventor
조성윤
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랩앤피플주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from KR1020190058730A external-priority patent/KR102310566B1/ko
Application filed by 랩앤피플주식회사 filed Critical 랩앤피플주식회사
Priority to JP2020564559A priority Critical patent/JP7317863B2/ja
Priority to BR112020023541-5A priority patent/BR112020023541B1/pt
Priority to US17/057,103 priority patent/US11679085B2/en
Priority to ES19807769T priority patent/ES2966155T3/es
Priority to EP19807769.5A priority patent/EP3782615B1/fr
Priority to CN201980033618.9A priority patent/CN112135609B/zh
Publication of WO2019225948A1 publication Critical patent/WO2019225948A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • the present invention relates to a patch for alleviating and preventing acne, and more particularly, to a new use of a biodegradable metal containing magnesium as a main component.
  • microneedles were proposed in 1998 by the Frausnits Group of Georgia Institute of Technology to make microneedle arrays of silicon devices using semiconductor process technology.
  • the microneedles When the microneedles are inserted into the skin, the microneedles must maintain a sufficiently high physical strength so that the microneedles can be inserted without being bent or broken.
  • stainless steel was used as the material of the microneedle, but inflammation occurred when small particles remained in the body, and polymers (PLA, PGA, and biodegradable copolymer) were used. There was a problem of not being penetration.
  • Korean Unexamined Patent Publication No. 2016-0058261 is a water-soluble microorganism based on polyglycolide (PGA), polylactide-glycolide copolymer (PLGA), hyaluronic acid, alginic acid, pectin and the like.
  • a needle and a manufacturing method thereof are disclosed, and
  • Korean Patent No. 1622388 discloses a silicon micro needle stamp and a manufacturing method thereof, and
  • Korean Patent Publication No. 2015-0121053 discloses a silicon, silicon dioxide, ceramic, metal (stainless steel, titanium, Nickel, molybdenum, chromium, cobalt and the like) and synthetic or natural resins have been disclosed for microneedle coated with Japanese encephalitis vaccine antigen.
  • the microneedle up to now is an alternative drug administration means that can replace the drug delivery method through oral administration or injection method, and penetrates the epidermis without stimulating pain sensory nerves distributed in the skin. It has been used as a device capable of delivering drugs, a kind of drug carrier.
  • Korean Patent Application Publication No. 2017-0115449 previously filed by the present applicant, discloses a microneedle using a biodegradable metal and a patch including the same. It has been confirmed that the effect is also expressed in wrinkle improvement.
  • the present invention seeks to provide a novel use of biodegradable metals, which are the main component of microneedles that have been developed as conventional drug delivery means.
  • the present invention is confirmed that the biodegradable metal itself, which was used as a main component of the microneedle, expresses antimicrobial activity against acne causing bacteria, and does not include a separate drug. We want to provide a new use.
  • the present invention is a biodegradable metal represented by the formula (1), and has an anti acne bacterium effect, provides a patch for acne relief and prevention.
  • X is the one or more selected from the group consisting of Ca, Fe, Mn, Si, Na, Zr, Ce and P.
  • the biodegradable metal may be included in the form of microneedles or in the form of a thin plate.
  • the biodegradable metal may be Mg of 95% or more pure purity including inevitable impurities.
  • the biodegradable metal may be one or more metal phases to generate a galvanic circuit to accelerate the decomposition rate.
  • Such biodegradable metal may be one comprising an Mg 2 Ca phase, one comprising an MgZn phase, or one comprising a Ca 2 Mg 6 Zn 3 phase.
  • the biodegradable metal may be coated with a second kind of second metal on the metal surface to form a galvanic circuit.
  • the second metal is selected from the group consisting of sodium, magnesium, potassium, iron, nickel, zinc, gallium, selenium, strontium, zirconium, molybdenum, niobium, tantalum, titanium, silicon, silver, gold, manganese and calcium It may be one or more metals.
  • Another embodiment of the present invention provides a method for attaching and using the aforementioned acne relief and prevention patch on acne skin.
  • the water supply step or the skin soothing step may be performed before the acne relief and prevention patch is attached to the acne skin.
  • the patch to which the biodegradable metal of the present invention is applied is useful for alleviating and preventing acne by having antimicrobial activity against acne causing bacteria on its own, without the need for a separate drug, and by using a simple method of applying it to the skin by making it in various forms. You can prevent acne or relieve the acne caused.
  • FIG. 1 is an exploded view of microneedles in which microneedles are processed into sheets composed of biodegradable metals.
  • FIG. 2 is a schematic view of a microneedle bent over the processed microneedles.
  • FIG 3 is a schematic view of a microneedle and microneedle holder in the form of a tip.
  • FIG. 4 is a prototype (A) of the microneedle of the present invention and a photograph (B) showing its bending characteristics.
  • FIG. 5 is a photograph of the microneedle patch of the present invention (A: before use, B: after use).
  • Figure 6 is a photograph of the specimen of the present invention microneedle provided in the antimicrobial test.
  • FIG. 7 to 9 are antimicrobial to antifungal test result photographs
  • FIG. 7 is a test result for Propionibacterium acnes ATCC 6919
  • FIG. 8 is a test result for Staphylococcus epidermidis ATCC 12228
  • FIG. 9 is a test for Trichophyton rubrum ATCC 28188. The result is.
  • 10-11 are schematic diagrams illustrating various shapes of the microneedle patch of the present invention.
  • FIG. 12 is a photograph showing the results of sensory evaluation by applying the microneedle patch of the present invention, showing the skin condition (right side) before attachment (left), attachment state (center), and 8 hours after attachment.
  • Figure 13 is a photograph showing an example attached to the test subject in the clinical trial applying the microneedle patch of the present invention.
  • FIG. 14 is an image showing a test site divided into six sections of a face area in an evaluation through a global acne grading system (GAGS) in a clinical trial.
  • GGS global acne grading system
  • FIG. 15 is a table showing intrinsic factors and global scores of each section shown in FIG. 14 in the evaluation through the acne severity system (GAGS) in clinical trials.
  • GGS acne severity system
  • FIG. 16 is a table of classification and status of adverse reactions in skin irritation evaluation in clinical trials.
  • 17 is a photograph showing the results of the photographing with the progress of the test period by attaching a magnesium microneedle patch to a test subject in a clinical trial.
  • Acne is a chronic inflammatory disease of the sebaceous gland of the hair sebaceous gland, and various skin changes such as cotton (Comedone, hardened sebum in hair follicles), papules (rising skin lesions less than 1 cm in size), pus blisters, nodules, and false cysts This may result in concave scars or enlarged scars. It occurs in the face, neck, chest, etc. where sebaceous glands are gathered, and inflammation of the sebaceous glands attached to hair follicles that make hair.
  • the exact cause of acne is not known, but several causes work in combination, rather than one cause.
  • the excess of male hormone during puberty stimulates the secretion of sebaceous glands, and the epithelium of hair follicles is dyskerosis (incomplete and immature keratinization).
  • Abnormal keratinization can cause hair follicles to be blocked, forming the scleroderma, the primary lesion of acne.
  • acne rash is known to be caused by propionibacterium acnes among the bacteria that reside in the hair follicles.
  • This acne-causing bacterium is the main cause of trouble when eating and growing sebum.In normal people, even if the bacteria are present on the skin, they do not cause any problems.However, since the hair follicles become clogged and sebum accumulates in the hair follicles, it grows quickly.
  • the acne-causing bacteria also eat fat (triglycerides) and then excrete butter-like substances, or fatty acids. This chemical change causes healthy weak acidic skin to alkalinize as the pH balance of oil breaks down, which in turn degrades the skin's own function and causes a vicious cycle of the skin.
  • a treatment method of a commonly used medicine or a medicine has been proposed.
  • the present invention was obtained as a result of continuous research on the microneedle developed as described above, and it was found that the biodegradable metal expresses antimicrobial activity against Propionibacterium acnes , an acne causing bacterium. By doing so, new applications of such biodegradable metals have been devised.
  • a substrate related to a biocompatible metal a substrate related to a method of manufacturing the same in the form of a microneedle, and a related substrate related to a series of metallic reactions occurring in the skin are according to the contents described in Korean Patent Application Publication No. 2017-0115449.
  • a substrate related to a biocompatible metal a substrate related to a method of manufacturing the same in the form of a microneedle, and a related substrate related to a series of metallic reactions occurring in the skin are according to the contents described in Korean Patent Application Publication No. 2017-0115449.
  • the biodegradable metal is not limited to the microneedles proposed as drug carriers, but it is clarified that the biodegradable metal acts alone as a functional composition having antibacterial activity against acne causing bacteria.
  • a biodegradable metal made of magnesium or zinc alone and a biodegradable metal mixed with other metals such as calcium in the form of a thin plate or a microneedle are prepared and their antibacterial activity against acne-causing bacteria was evaluated.
  • the biodegradable metal prepared by using magnesium, calcium, or zinc as a single material, or an alloy in which the metal is mixed in a specific range has its own antimicrobial activity without additional drug encapsulation.
  • the present invention provides a patch for acne alleviation and prevention, which is, in one aspect, a biodegradable metal represented by Formula 1 and having an antiacne bactericidal effect.
  • X is the one or more selected from the group consisting of Ca, Fe, Mn, Si, Na, Zr, Ce and P.
  • the biodegradable metal according to the present invention is a metal having the property of being attached or inserted into the subcutaneous or epithelium, and absorbed and decomposed to release metal ions and decomposition products in the body, and includes magnesium (Mg), calcium (Ca), and zinc ( Zn) and the like is an alkaline earth-based biodegradable metal, and has a mechanism for releasing hydrogen gas by reacting with water, as shown in Schemes 1 to 3 below.
  • the biodegradable metal may be preferably made of magnesium (Mg), zinc (Zn), or the like as a single material, and particularly in terms of excellent biocompatibility and no toxicity in normal cells or tissues. Most preferably, it may be a biodegradable metal that is magnesium alone.
  • magnesium single material or zinc single material means pure magnesium or zinc with a purity of 95% or more, in addition to including unavoidable impurities generated during metal production.
  • biodegradable metals can be made from two or more metals as a material in order to accelerate the rate of degradation in the subcutaneous or epithelium, ie to produce a galvanic circuit.
  • the biodegradable metal may be coated with another type of second metal on the surface of the biodegradable metal represented by Formula 1 to produce a galvanic circuit.
  • the second metal may include sodium, magnesium, potassium, iron, nickel, zinc, gallium, selenium, strontium, zirconium, molybdenum, niobium, tantalum, titanium, silicon, silver, gold, manganese, calcium, and the like. It is not limited. In this case, in the case of containing the iron (Fe), in particular, it should not contain cron or nickel.
  • the biodegradable metal may be included in the form of a thin plate or a microneedle.
  • the microneedle may be a conventional soluble microneedle in the industry such as laser cutting, sheet metal processing, casting method, and etching method. It can be prepared by a method for producing, the manufacturing method is not particularly limited. For example, after manufacturing the thin sheet 10 made of a biodegradable metal as shown in Figure 1 and then molded in a certain shape using a laser cutting machine (marking machine), the microneedle can be manufactured by bending in a jig press.
  • a patch containing such a biodegradable metal can be used for the purpose of acne relief and prevention by itself, without a separate drug coating or supporting.
  • FIG. 2 is a schematic diagram of the microneedles 11 bent to process the microneedles into the skin.
  • the microneedle according to the present invention may be formed in one piece or may be composed of the microneedle 20 and the microneedle holder 21 as shown in FIG. 3.
  • the microneedle utilizing the form of the microneedle holder 21 may be twisted after the needle is inserted to artificially allow the needle to remain subcutaneously.
  • Figure 4 is a prototype photograph (A) of the microneedle manufactured according to an embodiment of the present invention and a photograph (B) showing its bending characteristics.
  • such a microneedle can be manufactured in a patch form in terms of facilitating application to the skin.
  • the microneedle patch is for fixing the microneedle to the skin, and is composed of a microneedle and a patch portion formed on an opposite side of the microneedle.
  • the size, shape and material of the patch can be used without particular limitation.
  • the microneedles used may be ionized and discolored subcutaneously.
  • the patch containing the biodegradable metal of the present invention When the patch containing the biodegradable metal of the present invention is applied to the skin, it exhibits an anti-acne effect by itself without the inclusion or application of other drugs, but in the sense of doubling the effect or shortening the time of effect expression, It may be desirable to involve a hydration step or skin soothing step prior to applying the patch of the invention.
  • the moisture supply step may be performed through the application of various moisturizing cosmetics, for example, toner or moisture supply mist
  • the skin soothing step is to apply a functional cosmetics or medicines known to calm skin redness or acne
  • the method may be performed by, but is not limited to.
  • This water supply step or skin soothing step simply serves to assist the anti-acne effect of the patch containing the biodegradable metal of the present invention, and the effect of the patch of the present invention is not realized only when the step is preceded. .
  • the present invention has been developed a new use of the biodegradable metal applied in the form of microneedles for acne alleviation and prevention, the use is present in the skin using the above-described biodegradable metal as a specimen through the embodiments described below
  • the purpose of this study is to evaluate the activity of various bacteria, and to identify that it is only active against acne-causing bacteria.
  • the sample provided is a sheet made of pure Mg (magnesium of 95% or more purity) containing inevitable impurities generated during manufacture (thickness of 100 ⁇ m), and cut to a predetermined standard as shown in FIG. Used as
  • P. acnes were inoculated in Reinforced clostridial medium (RCM) broth and incubated at 35 ⁇ 1 ° C for 3 days.
  • the cultured bacterial solution was inoculated in fresh RCM broth and incubated under the same conditions as above, and this process was repeated one more time. All cultures of the strain were maintained in anaerobic conditions using sterile liquid paraffin. Then used as test bacteria.
  • S. epidermidis was inoculated into Brain heart infusion broth and cultured at (35 ⁇ 1) ° C for 18 to 24 hours before being used as test bacteria.
  • T. rubrum was inoculated in Sabouraud dextrose agar (25 ⁇ 1) and incubated for 14 days at °C. 0.05% polysorbate 80 solution was dispensed on the solid medium in which the test bacteria were grown, and spores were removed using a spreader, followed by gauze to remove mycelia. Spore solution prepared in this way was adjusted to (1 ⁇ 9) ⁇ 10 7 CFU / mL was used as the test bacteria.
  • Each fungal culture was evenly inoculated with a sterile swab on a prepared Reinforced clostridial medium (RCM) agar, Tryptic soy agar, and Sabouraud dextrose agar, and a prepared sample (20 mm ⁇ 20 mm) was placed in the center of the medium.
  • RCM Reinforced clostridial medium
  • S. epidermidis at (35 ⁇ 1) °C (24 ⁇ 2) hours
  • T. rubrum 25 ⁇ 1) °C Incubated for 7 days. Thereafter, the test was carried out by measuring the zone of inhibition around the sample.
  • the width (W) of the growth stop was calculated according to the following Equation 1.
  • T total diameter of sample and low zone (mm)
  • the total diameter (T) of the sample and the low zone was 32 mm
  • the diameter (D) of the sample was observed to 20mm. Therefore, according to the above formula, the width W of the low zone was confirmed to be 6.0 mm (see FIG. 7).
  • the total diameter (T) of the sample and lowland was 20 mm and the diameter (D) of the sample was 20 mm. Therefore, according to the above formula, the width W of the low land was confirmed to be 0.0 mm (see FIG. 8).
  • the total diameter (T) of the sample and lowland was 20 mm and the diameter (D) of the sample was 20 mm. Therefore, according to the above formula, the width W of the low zone was confirmed to be 0.0 mm (see Fig. 9).
  • the biodegradable metal of the present invention has antimicrobial activity only against acne causing bacteria, the rest of the antibacterial to antifungal effect was not observed.
  • a microneedle was manufactured using a laser marker (JTY FIBER MA20, JT Y System). At this time, the tip angles of the microneedles were 15 °, 30 °, and 35 °, and the needle heights were 0.5 mm, 1.0 mm, and 1.5 mm.
  • the microneedle patch was prepared by attaching a hydrocolloid patch coated with an adhesive to the opposite side where the needle of the microneedle was produced.
  • the prepared microneedle patch was packaged and sterilized.
  • microneedle patch may be manufactured in various shapes in terms of acne relief and prevention, and examples thereof may include shapes such as those illustrated in FIGS. 10 to 11.
  • the microneedle patch obtained was 7 male 15-year-old students with acne skin, and the patch was applied to one of the acne areas of the face after cleansing.
  • the evaluation criteria are 5 points for the acne treatment effect is significant, that is, the acne skin area is clearly reduced and the acne inflammation is clearly reduced. Rather, acne was worsened and evaluated as one point, and then a comprehensive judgment was made as a total score, and the results are shown in Table 2 below.
  • Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 Subject 6 Subject 7 Total score Invention microneedle patch 5 5 5 4 4 5 4 32
  • Figure 12 is a photograph showing the skin condition (left), the state of attachment (center), and the skin state (right) after 8 hours after attachment of the microneedle patch of a subject having forehead acne, from which the micro of the present invention Immediately after applying the needle patch, you'll see an immediate acne relief.
  • the test product was used once a day at the test site according to the prescribed method of use, and the effect was evaluated through visual evaluation.
  • the test site was carried out on the face area of the test subject.
  • the prescribed method of use is as follows.
  • FIG. 13 An example of applying a magnesium patch to a tester is shown in FIG. 13.
  • test subjects met the selection criteria, and 20 persons were selected and tested without the exclusion criteria.
  • test subjects suitable for the study After selecting the test subjects suitable for the study according to the selection and exclusion criteria, confirming the skin condition of the test subjects, and performing visual evaluation and photographing (VISIA-CR) before using the product (0 days) and 1 day of using the product, respectively. Then, 3 days after product use, 4 days after product use, and 5 days after product use.
  • VIPSIA-CR visual evaluation and photographing
  • test subjects were allowed to settle for 30 minutes in the waiting room under constant temperature and humidity (22 ⁇ 2 °C, RH40 ⁇ 60%) to adapt the skin surface temperature and humidity to the environment of the measurement space.
  • constant temperature and humidity 22 ⁇ 2 °C, RH40 ⁇ 60%
  • the device was evaluated by one investigator and the same area was measured by each researcher.
  • Photographs were taken with full face photographs using facial cameras (VISIA-CR, Canfield, USA) equipped with cameras (Canon, EOS6D, JAPAN), and the standard 2 measurement mode was used. Facial cameras (VISIA-CR, Canfield) fix the forehead and the chin to minimize the subject's movement, and the gray card is photographed together to see the change of light when shooting. Measurements were made before product use (day 0), after product use 1 day, after product use 3 days, and after product use 5 days. The overlay function was used to capture the same area, and only images were used in this study.
  • GAGS Global Acne Grading System
  • each subject was surveyed for the general evaluation (feeling) of the test product, evaluation of change after use, satisfaction with the product, and adverse reactions.
  • the evaluation of the questionnaire by the test subjects answered the questionnaire directly in five stages (5), satisfaction (4), moderate (3), dissatisfaction (2), and very dissatisfaction (1) for the measured items after using the test product. To do so.
  • the investigator determined the efficacy of the test product by obtaining a percentage of the number of subjects for each response.
  • the subjects were asked to answer the questionnaire about the test product and the feeling of use after use.
  • the evaluation items were evaluated in five stages: general satisfaction (feeling of use) and satisfaction with the product.
  • the visual evaluation result was conducted by comparing the difference before and after using the product, and the evaluation method was evaluated using the method described in item 3) of the above (2).
  • the paired t-test method was used for changes before and after the use of the product, and the statistical results were statistically significant when the significant difference of 5% (p ⁇ 0.05) used in the biological statistical analysis. Considered.
  • the survey results and product preferences were also evaluated based on the survey results.
  • the subjects who participated in this study were selected from 20 healthy adult male and female subjects with an average age of 21.9 ⁇ 2.9.
  • the 20 subjects completed the final test without dropping out.
  • test product showed statistically significant difference after 1 day of test product use, 3 days after product use, and 5 days after product use compared to before product use (day 0).
  • the skin irritation evaluation (self-evaluation) results of the test subjects are shown in Table 6 below.
  • the selective anti-acne bactericidal activity of the patch containing the non-toxic biodegradable metal having excellent biocompatibility is mainly due to the increase of the local pH due to OH - ions generated during the decomposition of the metals shown in Schemes 1 to 3. It is expected that, if the pure magnesium or pure zinc metal containing the components according to the formula (1) to accelerate the decomposition rate, a faster antibacterial effect is expected.
  • the patch to which the biodegradable metal of the present invention is applied is useful for alleviating and preventing acne by having antimicrobial activity against acne causing bacteria on its own without carrying a separate drug, and by using a simple method of applying it to the skin by manufacturing it in various forms It may be useful as a patch to prevent acne or to alleviate the caused acne.

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Abstract

La présente invention concerne un timbre destiné à l'atténuation et à la prévention de l'acné dans lequel une activité anti-bactéries acnéiques est identifiée pour un métal biodégradable représenté par MgaZnbXc (dans laquelle, a, b et c représentent le pourcentage en poids de chaque constituant, a + b + c = 100 pour cent en poids, a ou b est le plus grand parmi 0 ≤ a ≤ 100, 0 ≤ b ≤ 100, et 0 ≤ c ≤ 10, et X est au moins un élément choisi dans le groupe constitué par le Ca, le Fe, le Mn, le Si, le Na, le Zr, le Ce et le P), et une nouvelle utilisation sous forme de timbre pour l'atténuation et la prévention de l'acné.
PCT/KR2019/006068 2018-05-21 2019-05-21 Timbre pour l'atténuation et la prévention de l'acné WO2019225948A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2020564559A JP7317863B2 (ja) 2018-05-21 2019-05-21 ニキビ緩和及び予防用パッチ
BR112020023541-5A BR112020023541B1 (pt) 2018-05-21 2019-05-21 Adesivo para alívio e prevenção de acne
US17/057,103 US11679085B2 (en) 2018-05-21 2019-05-21 Patch for alleviation and prevention of acne
ES19807769T ES2966155T3 (es) 2018-05-21 2019-05-21 Parche para el alivio y prevención del acné
EP19807769.5A EP3782615B1 (fr) 2018-05-21 2019-05-21 Timbre pour l'atténuation et la prévention de l'acné
CN201980033618.9A CN112135609B (zh) 2018-05-21 2019-05-21 痤疮缓解及预防用贴片

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KR20180057629 2018-05-21
KR10-2018-0057629 2018-05-21
KR10-2019-0058730 2019-05-20
KR1020190058730A KR102310566B1 (ko) 2018-05-21 2019-05-20 여드름 완화 및 예방용 패치

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006116281A2 (fr) * 2005-04-25 2006-11-02 Johnson & Johnson Consumer Companies, Inc. Methode de traitement de l'acne au moyen d'un dispositif de perçage de la couche cornee
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KR101622388B1 (ko) 2015-10-21 2016-05-19 한국과학기술원 실리콘 마이크로 니들 스탬프 및 그 제조방법
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