WO2019210203A1 - Compositions et procédés de ciblage de gpr35 pour le traitement d'une affection abdominale inflammatoire - Google Patents

Compositions et procédés de ciblage de gpr35 pour le traitement d'une affection abdominale inflammatoire Download PDF

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Publication number
WO2019210203A1
WO2019210203A1 PCT/US2019/029398 US2019029398W WO2019210203A1 WO 2019210203 A1 WO2019210203 A1 WO 2019210203A1 US 2019029398 W US2019029398 W US 2019029398W WO 2019210203 A1 WO2019210203 A1 WO 2019210203A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
allele
gpr35
instances
subject
Prior art date
Application number
PCT/US2019/029398
Other languages
English (en)
Inventor
Dermot P. Mcgovern
Janine Bilsborough
Stephan Targan
Manreet KAUR
Alka POTDAR
Robert Higuchi
Original Assignee
Cedars-Sinai Medical Center
Precision Ibd, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Cedars-Sinai Medical Center, Precision Ibd, Inc. filed Critical Cedars-Sinai Medical Center
Publication of WO2019210203A1 publication Critical patent/WO2019210203A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés, des kits et des compositions pour traiter un sujet atteint d'une maladie abdominale inflammatoire. Ces procédés, kits et compositions peuvent être particulièrement utiles pour des sujets présentant des polymorphismes mononucléotidiques dans un locus de gène codant le récepteur couplé à la protéine G 35 (GPR35).
PCT/US2019/029398 2018-04-27 2019-04-26 Compositions et procédés de ciblage de gpr35 pour le traitement d'une affection abdominale inflammatoire WO2019210203A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862663800P 2018-04-27 2018-04-27
US62/663,800 2018-04-27
US201962796471P 2019-01-24 2019-01-24
US62/796,471 2019-01-24

Publications (1)

Publication Number Publication Date
WO2019210203A1 true WO2019210203A1 (fr) 2019-10-31

Family

ID=68295798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/029398 WO2019210203A1 (fr) 2018-04-27 2019-04-26 Compositions et procédés de ciblage de gpr35 pour le traitement d'une affection abdominale inflammatoire

Country Status (2)

Country Link
TW (1) TW202014217A (fr)
WO (1) WO2019210203A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114129562A (zh) * 2020-09-03 2022-03-04 中国科学院大连化学物理研究所 香豆素类衍生物在制备治疗炎症性肠炎药物中应用及药物
US11773101B2 (en) 2019-01-24 2023-10-03 Prometheus Biosciences, Inc. GPR35 modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110229471A1 (en) * 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
US20150259748A1 (en) * 2004-12-08 2015-09-17 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease
WO2017003501A1 (fr) * 2015-06-30 2017-01-05 Halliburton Energy Services, Inc. Diagnostiques de pression à écoulement continu et en temps réel à des fins d'analyse et de conception de cycles de déviation pour des opérations de fracturation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150259748A1 (en) * 2004-12-08 2015-09-17 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease
US20110229471A1 (en) * 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2017003501A1 (fr) * 2015-06-30 2017-01-05 Halliburton Energy Services, Inc. Diagnostiques de pression à écoulement continu et en temps réel à des fins d'analyse et de conception de cycles de déviation pour des opérations de fracturation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE Nucleotide [online] 20 June 2002 (2002-06-20), "Homo sapiens chromosome 2 clone RP13-511H14", XP055647897, retrieved from NCBI Database accession no. AC111190.2 *
LAURA JENKINS ET AL.: "Antagonists of GPR35 display high species ortholog selectivity and varying modes of action", J PHARMACOL EXP THER, vol. 343, no. 3, December 2012 (2012-12-01), pages 683 - 695, XP055647894, DOI: 10.1124/jpet.112.198945 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11773101B2 (en) 2019-01-24 2023-10-03 Prometheus Biosciences, Inc. GPR35 modulators
CN114129562A (zh) * 2020-09-03 2022-03-04 中国科学院大连化学物理研究所 香豆素类衍生物在制备治疗炎症性肠炎药物中应用及药物

Also Published As

Publication number Publication date
TW202014217A (zh) 2020-04-16

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