WO2019181553A1 - Système de microscope chirurgical - Google Patents

Système de microscope chirurgical Download PDF

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Publication number
WO2019181553A1
WO2019181553A1 PCT/JP2019/009267 JP2019009267W WO2019181553A1 WO 2019181553 A1 WO2019181553 A1 WO 2019181553A1 JP 2019009267 W JP2019009267 W JP 2019009267W WO 2019181553 A1 WO2019181553 A1 WO 2019181553A1
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Prior art keywords
optical path
path length
light
tomographic image
optical
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PCT/JP2019/009267
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English (en)
Japanese (ja)
Inventor
大月　知之
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ソニー株式会社
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Publication of WO2019181553A1 publication Critical patent/WO2019181553A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions

Definitions

  • the present technology relates to a surgical microscope system, and more particularly to a surgical microscope system in which a microscope barrel can be miniaturized.
  • Such a request for a high-speed acquisition range change includes a change in the depth direction, that is, a position adjustment of the acquisition range in the depth direction.
  • the depth direction at the time of tomographic image acquisition that is, the acquisition range in the optical axis direction is generally adjusted by moving the position of the microscope barrel in the optical axis direction. Therefore, it was difficult to change the acquisition range at high speed.
  • Patent Document 1 it is possible to change the acquisition range of the tomographic image at a relatively high speed, but it is necessary to provide a drive unit for moving the light emission area inside the microscope barrel.
  • the microscope barrel becomes large.
  • the present technology has been made in view of such a situation, and enables a reduction in the size of a microscope barrel.
  • a surgical microscope system includes a microscope optical system for observing a biological tissue that is an observation target, reflected light of observation light irradiated on the biological tissue, and reference light that is not irradiated on the biological tissue.
  • a tomographic information acquisition optical system for acquiring tomographic information of the living tissue using the interference, and the tomographic information acquisition optical system includes an optical path length adjustment unit that adjusts an optical path length of the reference light.
  • a surgical microscope system includes a microscope optical system for observing a biological tissue that is an observation target, reflected light of observation light that is irradiated on the biological tissue, and reference that is not irradiated on the biological tissue
  • a tomographic information acquisition optical system for acquiring tomographic information of the living tissue using interference with light, and an optical path length adjustment unit for adjusting an optical path length of the reference light in the tomographic information acquisition optical system Is provided.
  • the microscope barrel can be reduced in size.
  • FIG. 1 It is a figure which shows the structural example of a surgical microscope system. It is a figure which shows the structural example of an image information acquisition part. It is a figure which shows the structural example of an optical path length adjustment part. It is a figure which shows the structural example of an optical path length adjustment part. It is a figure explaining the interlock control of an OCT focus position and a tomographic image acquisition range. It is a flowchart explaining a tomographic information acquisition process. It is a figure which shows the structural example of a computer.
  • FIG. 1 is a diagram illustrating a configuration example of an embodiment of a surgical microscope system to which the present technology is applied.
  • the surgical microscope system 11 shown in FIG. 1 is for observing a site such as a patient's eye, which is a surgical target, before or during surgery.
  • This surgical microscope system 11 has a function of acquiring tomographic information indicating a tomographic image of a site to be observed, that is, a site to be operated by, for example, an OCT (optical coherence tomography), and a microscope observation such as a bright field of the site to be observed. It has the function to acquire the front image obtained by this.
  • OCT optical coherence tomography
  • any observation target may be used as long as it is a living tissue, but in the following, in order to simplify the explanation, a case where the observation target living tissue is a patient's eye will be described as an example.
  • the surgical microscope system 11 includes an image information acquisition unit 21, an image processing unit 22, and a display unit 23.
  • the image information acquisition unit 21 includes a microscope with a tomographic image acquisition function, and acquires image information of the eye to be operated and supplies it to the image processing unit 22.
  • the image information acquisition unit 21 uses, as image information, a tomographic image of the eye to be operated, that is, a tomographic image that is an image of a cross section of the eye, or a front image obtained by microscopic observation of the eye to be operated. get.
  • the microscopic observation here is, for example, bright field observation, phase difference observation, fluorescence observation, etc., but the description will be continued below assuming that the eye to be operated is observed in the bright field.
  • the image information acquisition unit 21 may acquire a tomographic image of a specified tomographic plane, acquire tomographic information of a wide range of eyes as volume data, and specify a position (tomographical fault) in the volume data.
  • Plane) tomographic image may be generated by synthesis.
  • a continuous tomographic image acquired in a certain time range may be acquired as a moving image.
  • the image processing unit 22 controls the display of display information on the display unit 23 based on the image information supplied from the image information acquisition unit 21 and controls the operation of the image information acquisition unit 21.
  • the image processing unit 22 includes an image recognition unit 31, an interface unit 32, a control unit 33, and a display information generation unit 34.
  • the image recognition unit 31 performs image recognition processing on the image information supplied from the image information acquisition unit 21, that is, a tomographic image or a front image, and supplies the recognition result to the control unit 33. For example, in the image recognition process, a region such as a predetermined part of a surgical target eye or a surgical tool is recognized from image information.
  • the interface unit 32 acquires various types of information by accepting an input operation by the user or communicating with other surgical devices, and supplies the information to the control unit 33.
  • the control unit 33 controls each unit of the surgical microscope system 11 using the recognition result supplied from the image recognition unit 31 and the information supplied from the interface unit 32 as necessary.
  • the display information generation unit 34 processes the image information supplied from the image information acquisition unit 21 under the control of the control unit 33 and generates display information.
  • the display information may be a tomographic image or a front image itself, or may be an image in which information indicating a menu, a tomographic position, or the like is superimposed on these images.
  • the display information generation unit 34 supplies the generated display information to the display unit 23.
  • the display unit 23 includes a display device such as a liquid crystal display, and displays the display information supplied from the display information generation unit 34.
  • the image information acquisition unit 21 is configured as shown in FIG. 2, for example.
  • the image information acquiring unit 21 shown in FIG. 1 includes a light source 61, a coupler 62, an optical path length adjusting unit 63, a light receiving unit 64, and a microscope barrel 65.
  • a collimating lens 71 for example, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam 71, a laser beam, and a microscope optical system 75 are provided inside the microscope barrel 65.
  • the light source 61 to the microscope barrel 65 in particular, the light source 61, the coupler 62, the optical path length adjusting unit 63, the light receiving unit 64, the collimating lens 71, the scanning unit 72, the OCT focus lens 73, and the objective lens 74 are used for surgery. It is provided as a configuration for obtaining a tomographic image of the target eye EY11. That is, the OCT is configured by the light source 61 to the objective lens 74.
  • the microscope barrel 65 is used not only for obtaining a tomographic image but also for obtaining a front image of the eye EY11. That is, a microscope for observing the eye EY11 with a microscope is configured by the objective lens 74 and the microscope optical system 75 provided in the microscope barrel 65, a light source (not shown), an image sensor, and the like. It is a microscope barrel.
  • the coupler 62 is made of a 2 ⁇ 2 optical fiber coupler and includes an optical fiber 81 and an optical fiber 82.
  • a light source 61 is connected to one end of the optical fiber 81, and a collimator lens 71 is connected to the other end of the optical fiber 81.
  • the light source 61 is a light source that outputs observation light and reference light at the time of tomographic image acquisition, and the collimator lens 71 collects light incident from the optical fiber 81 and makes it incident on the scanning unit 72 or scan.
  • This is an optical lens that guides light incident from the section 72 to the optical fiber 81.
  • the light receiving unit 64 is connected to one end of the optical fiber 82, and the optical path length adjusting unit 63 is connected to the other end of the optical fiber 82.
  • the light receiving unit 64 includes, for example, an image sensor, and the optical path length adjusting unit 63 is an optical path length adjusting mechanism that adjusts the optical path of incident light.
  • the coupler 62 when light enters one end of the optical fiber 81, a part of the light is guided to the other end of the optical fiber 81, and the remaining light is on the other end side of the optical fiber 81. To the end of the optical fiber 82.
  • the direction of the other end of the optical fiber 81 and the optical fiber at the joint between the optical fiber 81 and the optical fiber 82 Branches in the direction of the end of the optical fiber 82 on the other end side of 81.
  • a part of the light output from the light source 61 is light that passes through the optical fiber 81 and is applied to the eye EY11. It enters the collimating lens 71 as observation light.
  • the observation light incident on the collimating lens 71 is collected by the collimating lens 71 and irradiated to the eye EY11 through the scanning unit 72, the OCT focus lens 73, and the objective lens 74.
  • observation light more specifically, reflected light of observation light
  • a part of the observation light passes through the inside of the optical fiber 81, and then passes through the optical fiber 82 at the coupling portion.
  • the light advances to the fiber 82 and enters the light receiving unit 64.
  • An optical system that guides the observation light output from the light source 61 to the light receiving unit 64 that is, an optical system including the coupler 62, the collimating lens 71, the scanning unit 72, the OCT focus lens 73, and the objective lens 74,
  • the observation optical system 91 is used when acquiring a tomographic image by OCT.
  • the optical path of the observation light passing through the observation optical system 91 that is, the optical path of the observation light from the light source 61 to the light receiving unit 64 will be particularly referred to as a sample arm.
  • the optical path length of the observation light is also referred to as the length of the sample arm or the optical path length of the sample arm.
  • the light that travels to the optical fiber 82 instead of the observation light among the light output from the light source 61 becomes the reference light.
  • This reference light is light that is used to acquire a tomographic image, but is not irradiated to the eye EY11 to be observed.
  • the reference light is output from the light source 61, it passes through the inside of the optical fiber 81, proceeds to the optical fiber 82 side at the coupling portion with the optical fiber 82, and is arranged on the optical path of the reference light. Led to.
  • the reference light incident on the optical path length adjusting unit 63 is reflected at the end inside the optical path length adjusting unit 63 and enters the optical fiber 82. That is, the reference light that has entered the optical path length adjustment unit 63 from the optical fiber 82 is reflected by the end inside the optical path length adjustment unit 63 and returns to the optical fiber 82.
  • the reference light incident on the optical fiber 82 from the optical path length adjustment unit 63 passes through the optical fiber 82 as it is and enters the light receiving unit 64.
  • An optical system that guides the reference light output from the light source 61 to the light receiving unit 64 that is, an optical system including the coupler 62 and the optical path length adjusting unit 63, is a reference optical system 92 at the time of tomographic image acquisition by OCT.
  • observation optical system 91 and the reference optical system 92 constitute a tomographic information acquisition optical system 101 for acquiring a tomographic image (tomographic information) of the surgical target, that is, the eye EY11 to be observed.
  • the optical path of the reference light passing through the reference optical system 92 that is, the optical path of the reference light from the light source 61 to the light receiving unit 64 will be particularly referred to as a reference arm.
  • the optical path length of the reference light is also referred to as a reference arm length or a reference arm optical path length.
  • observation light and reference light are incident on the light receiving unit 64.
  • the light receiving unit 64 receives the observation light and the reference light incident from the optical fiber 82, performs photoelectric conversion, and outputs a signal indicating image information obtained as a result, that is, a signal indicating a tomographic image, as tomographic information.
  • the image information acquisition unit 21 generates a tomographic image based on the tomographic information at a plurality of positions in the eye EY11 output from the light receiving unit 64.
  • the tomographic image is an image of a cross section of the eye EY11 parallel to the optical axis of the objective lens 74.
  • the surface of the eye EY11 where the length of the sample arm is equal to the length of the reference arm is the tomographic image acquisition surface, and more specifically, the tomographic image acquisition surface, more specifically, the region near the tomographic image acquisition surface is the reflective surface.
  • an image of the tomographic image acquisition surface (reflection surface) of the eye EY11 is obtained as a tomographic image.
  • the tomographic image acquisition plane of the eye EY11 is a plane perpendicular to the optical axis of the observation optical system 91 in the eye EY11, more specifically the optical axes of the OCT focus lens 73 and the objective lens 74.
  • the tomographic image acquisition range is set as the tomographic image acquisition range, and the eye EY11
  • the image information of the tomographic image acquisition range is acquired as a tomographic image (tomographic information).
  • the tomographic image acquisition range is a region from which tomographic information is acquired by the eye EY11.
  • the direction of the optical axis of the OCT focus lens 73 and the objective lens 74 that is, the vertical direction in FIG. 2 is also referred to as the Z direction.
  • directions perpendicular to the Z direction and orthogonal to each other are also referred to as an X direction and a Y direction.
  • the length in the Z direction of the tomographic image acquisition range that is, the range in the Z direction as the acquisition target of the tomographic image is a range having a predetermined length centered on the tomographic image acquisition surface.
  • the interference between the observation light and the reference light is used for obtaining the tomographic image. Therefore, by adjusting the length (optical path length) of the sample arm or reference arm, it is possible to adjust the position (range) in the Z direction of the tomographic image acquisition range, that is, the position in the depth direction of the tomographic image acquisition surface. It is.
  • the image information acquisition unit 21 does not adjust the optical path length of the sample arm, makes the optical path length of the reference arm variable, and adjusts it to an appropriate length so that the position in the Z direction of the tomographic image acquisition range can be arbitrarily set.
  • the position can be set.
  • the position adjustment in the XY direction of the tomographic image acquisition range is realized by scanning the observation light in the X direction or the Y direction by the scanning unit 72. This is because the position (range) in the XY direction where the observation light is irradiated on the eye EY11 is the position (range) in the XY direction of the tomographic image acquisition range.
  • the scanning unit 72 is composed of a pair of scan mirror 111-1 and scan mirror 111-2 which are arranged so that the reflecting surfaces face each other in parallel.
  • Such a scanning unit 72 functions as an OCT scanning system that scans observation light in the X and Y directions, that is, a scanner.
  • the observation light from the collimator lens 71 is reflected by the scan mirror 111-1, further reflected by the scan mirror 111-2, and guided to the OCT focus lens 73.
  • the scan mirror 111-1 and the scan mirror 111-2 are also simply referred to as the scan mirror 111 when it is not necessary to distinguish between them.
  • the optical path of the observation light is changed by rotating the pair of scan mirrors 111, so that the observation light can be irradiated to an arbitrary position in the XY direction of the eye EY11. It can be done.
  • the focusing position of the observation light in the Z direction that is, the focus position of the observation light can be adjusted by the OCT focus lens 73.
  • the OCT focus lens 73 is arranged on the optical path of the observation light to constitute the observation optical system 91, but is not an optical element constituting an optical system for observing the eye EY11 in bright field. That is, the OCT focus lens 73 is not disposed on the optical path of light for observing the eye EY11 in bright field. Therefore, for example, even when tomographic information is acquired during bright field observation, the focus position of the observation light can be adjusted without affecting the bright field observation by using the OCT focus lens 73.
  • the focus position of the observation light in the Z direction is particularly referred to as the OCT focus position.
  • the OCT focus lens 73 is composed of a variable focus lens whose shape (lens shape) changes according to an applied voltage.
  • shape of the OCT focus lens 73 changes, the refractive power of the OCT focus lens 73, that is, the focal position, changes, so that the OCT focusing position also changes.
  • the OCT focus position may be adjusted by changing the position of the OCT focus lens 73 in the Z direction, or the refractive power of the OCT focus lens 73 and the change of the position in the Z direction may be adjusted. May be combined to adjust the OCT focusing position.
  • a microscope optical system 75 for bright-field observation of the eye EY11 is provided inside the microscope barrel 65.
  • the microscope optical system 75 includes an illumination system and an imaging optical system.
  • illumination light output from a light source passes through the illumination optical system and the objective lens 74 of the microscope optical system 75.
  • the illumination light reflected by the surface of the eye EY11 becomes bright field observation light, and the bright field observation light passes through the objective lens 74 and the imaging optical system of the microscope optical system 75 to an image sensor (not shown). And incident.
  • the image sensor receives the bright field observation light incident from the imaging optical system and photoelectrically converts the bright field observation light, thereby capturing a front image that is a bright field image of the eye EY11.
  • ⁇ Configuration example of optical path length adjustment unit> By the way, in a general microscope system equipped with an OCT, as a method of changing the position in the Z direction of the tomographic image acquisition range, that is, the range in the depth direction of OCT imaging, the entire microscope column corresponding to the microscope column 65 is used. A method for moving the lens in the Z direction and a method for moving the lens corresponding to the collimating lens 71 in the optical axis direction are employed. In any of these methods, the position of the tomographic image acquisition range in the Z direction is adjusted by adjusting at least the optical path length of the sample arm.
  • the position of the tomographic image acquisition range in the Z direction can be adjusted by adjusting only the optical path length of the reference arm by the optical path length adjustment unit 63 without adjusting the optical path length of the sample arm. .
  • the optical path length adjustment unit 63 for adjusting the optical path length can be disposed outside the microscope barrel 65, thereby the microscope barrel 65.
  • a configuration advantageous for downsizing is realized. That is, the microscope barrel 65 can be reduced in size.
  • the optical path length adjustment unit 63 is disposed on the optical path of the reference light and outside the microscope barrel 65, so that the microscope barrel 65 is downsized.
  • the portion of the eye EY11 that has the same optical path length as that of the reference arm in the sample arm is used as a tomographic image acquisition surface, and a tomographic image in the tomographic image acquisition range including the tomographic image acquisition surface is captured.
  • the optical path length of the reference arm may be changed in adjusting the position in the Z direction of the tomographic image acquisition range, that is, the range in the depth direction (Z direction) from which tomographic images are acquired.
  • the optical path length of the reference arm is adjusted by the optical path length adjustment unit 63.
  • the optical path length adjustment unit 63 can be configured as shown in FIGS. 3 and 4. 3 and 4, the same reference numerals are given to the portions corresponding to those in FIG. 2, and description thereof will be omitted as appropriate.
  • the optical path length adjustment unit 63 includes a collimating lens 201, a reference mirror 202, and a driving unit 203.
  • the collimating lens 201 and the reference mirror 202 are arranged on the optical path of the reference light, and in particular, the collimating lens 201 is arranged at the end portion of the optical fiber 82.
  • the reference light guided by the optical fiber 82 and incident on the optical path length adjustment unit 63 is condensed by the collimator lens 201 and incident on the reference mirror 202.
  • the reference light that has entered the reference mirror 202 from the collimator lens 201 is reflected by the reference mirror 202 and enters the optical fiber 82 via the collimator lens 201.
  • the reference light incident on the optical fiber 82 in this way enters the light receiving unit 64 through the optical fiber 82.
  • the reference mirror 202 whose arrangement position is variable is arranged on the optical path of the reference light, and the optical path length of the reference light is adjusted by changing the arrangement position of the reference mirror 202. .
  • the optical path length adjusting unit 63 physically moves the reference mirror 202 disposed on the optical path of the reference light in a direction parallel to the traveling direction of the reference light, that is, in the direction indicated by the arrow A11 in the drawing.
  • a drive unit 203 is provided.
  • the drive unit 203 moves the reference mirror 202, the distance from the collimating lens 201 to the reference mirror 202 changes, so that the optical path length of the reference light, that is, the optical path length of the reference arm changes.
  • the optical path length adjustment unit 63 includes a delay line 231, a collimator lens 232, and a reference mirror 233.
  • the delay line 231, the collimating lens 232, and the reference mirror 233 are arranged on the optical path of the reference light.
  • a delay line 231 is disposed at the end portion of the optical fiber 82, and a collimator lens 232 is disposed between the delay line 231 and the reference mirror 233.
  • the reference light guided by the optical fiber 82 and incident on the optical path length adjusting unit 63 enters the collimator lens 232 via the delay line 231, is condensed by the collimator lens 232, and enters the reference mirror 233. .
  • the reference light that has entered the reference mirror 233 from the collimator lens 232 is reflected by the reference mirror 233 and enters the optical fiber 82 via the collimator lens 232 and the delay line 231.
  • the reference light incident on the optical fiber 82 in this way enters the light receiving unit 64 through the optical fiber 82.
  • the delay line 231 is configured by a device called an optical delay line, and the delay line 231 can electrically control the delay of the reference light, that is, adjust the optical path length of the reference light.
  • the refractive index inside the delay line 231 changes, thereby changing the optical path length of the reference light, that is, the optical path length of the reference arm.
  • the optical path length of the reference arm is adjusted by the delay line 231
  • the optical path length can be adjusted at a higher speed than when the reference mirror 202 is physically moved as shown in FIG.
  • the optical path length of the reference arm is adjusted by combining the configuration for moving the reference mirror as shown in FIG. 3 and the configuration using the delay line as shown in FIG.
  • the optical path length of the reference arm may be adjusted by other configurations. Therefore, for example, in the optical path length adjusting unit 63 shown in FIG. 4, the arrangement position of the reference mirror 233 may be variable.
  • the position in the Z direction of the tomographic image acquisition range is faster than the method of moving the entire microscope barrel. Can be adjusted.
  • a general microscope system equipped with OCT controls the focus position during bright-field observation with a microscope, that is, controls the OCT focus position independently of focus control during bright-field observation. Some are configured to be able to.
  • a plurality of types of focus lenses corresponding to the OCT focus lens 73 are prepared, and any one of these focus lenses is selectively arranged on the optical path of the observation light, so that the OCT focus position is obtained.
  • it is configured to change the above.
  • the OCT focusing position is adjusted by exchanging the focus lens arranged on the sample arm.
  • a fixed-shaped focus lens corresponding to the OCT focus lens 73 is moved in the optical axis direction to thereby move the OCT.
  • a method for adjusting the in-focus position is also known.
  • a variable focus lens is employed as the OCT focus lens 73 in order to make it possible to electrically control the focus changing mechanism.
  • the lens shape of the OCT focus lens 73 can be changed by electrical control.
  • the refractive power of the OCT focus lens 73 changes, and as a result, the OCT focus position changes.
  • the OCT focusing lens 73 is replaced at a higher speed than when the OCT focus lens 73 is replaced or when the OCT focus lens 73 is moved in the optical axis direction.
  • the focal position can be changed. Thereby, for example, the OCT focusing position can be adjusted continuously at a high speed following the surgical instrument used for the operation of the eye EY11.
  • Some general microscope systems equipped with an OCT include a mechanism for adjusting a tomographic image acquisition range and a mechanism for adjusting an OCT focusing position.
  • the position in which the surgeon pays attention that is, the position in the tomographic image acquisition range, and the OCT focusing position become large in the Z direction, and the operator cannot focus on the focus. That is, the tomographic image may be blurred.
  • FIG. 5 it is assumed that a tomographic image is acquired by irradiating the eye EY11 with a beam BM11 as observation light.
  • parts corresponding to those in FIG. 2 are denoted by the same reference numerals, and description thereof is omitted as appropriate.
  • the vertical direction in the figure is the Z direction
  • the position indicated by the arrow Q11 in the Z direction is the OCT focusing position.
  • This OCT in-focus position is a position where the beam BM11 which is the observation light is most converged in the Z direction, that is, a position where the beam diameter of the beam BM11 is the smallest.
  • the range indicated by the arrow Q12 is the Z direction range of the tomographic image acquisition range
  • the position indicated by the arrow Q13 is the Z direction of the tomographic image acquisition range among the Z direction range of the tomographic image acquisition range.
  • the position indicated by the arrow Q13 is the tomographic image acquisition plane.
  • the OCT focusing position is located on the tomographic image acquisition surface.
  • the OCT focusing position is located within the tomographic image acquisition range, a clear tomographic image in focus on the tomographic image acquisition surface can be obtained.
  • the OCT focusing position is a position on the tomographic image acquisition plane, but the OCT focusing position is not within the tomographic image acquisition plane but is positioned within the tomographic image acquisition range. If so, a clear tomographic image can be obtained. Therefore, the OCT focusing position is not limited to the position on the tomographic image acquisition surface, and may be any position as long as it is within the tomographic image acquisition range.
  • control unit 33 controls the optical path length adjustment unit 63 while the OCT focusing position is fixed, and changes the position in the Z direction of the tomographic image acquisition range.
  • the OCT focusing position does not change and the tomographic image acquisition range moves in the Z direction, it is not guaranteed that the OCT focusing position is located within the tomographic image acquisition range after adjustment of the tomographic image acquisition range. .
  • the OCT focusing position may be located outside the tomographic image acquisition range.
  • the tomographic image obtained by the image information acquisition unit 21 may become unclear.
  • the surgical microscope system 11 can obtain a focused and clear tomographic image by controlling the OCT focusing position and the tomographic image acquisition range to be adjusted in conjunction with each other. That is, it is possible to obtain a tomographic image focused on the position focused by the operator.
  • the operation of the optical path length adjustment unit 63 is controlled by the control unit 33, and the optical path length of the reference arm is adjusted.
  • control unit 33 grasps the optical path length of the reference arm, the position in the Z direction of the tomographic image acquisition range determined with respect to the optical path length of the reference arm, that is, the Z direction in which the tomographic image is to be acquired. It is possible to specify a range.
  • the control unit 33 also controls the OCT focus lens 73, that is, adjusts the OCT focusing position.
  • control unit 33 knows not only the position in the Z direction of the tomographic image acquisition range but also the OCT focusing position, the OCT focusing is always performed so that the OCT focusing position is located within the tomographic image acquisition range.
  • the position and the tomographic image acquisition range can be changed in conjunction with each other.
  • the control unit 33 controls the optical path length adjustment unit 63 and the OCT focus lens 73 so that the OCT focus position is always within the tomographic image acquisition range.
  • the OCT focusing position may be adjusted to be a fixed position within the tomographic image acquisition range, such as a position on the tomographic image acquisition surface. That is, in this case, the controller 33 controls the adjustment of the OCT focusing position and the position of the tomographic image acquisition range so that the relative position of the OCT focusing position with respect to the tomographic image acquisition range is always the same position. become.
  • a plurality of positions within the tomographic image acquisition range are sequentially set as the OCT focusing positions, and the tomographic information is acquired for each of the plurality of OCT focusing positions.
  • the OCT in-focus position may be scanned in the Z direction within the tomographic image acquisition range while the position of the tomographic image acquisition range is fixed.
  • the image information acquisition unit 21 performs image processing based on the tomographic information obtained for each OCT in-focus position to obtain one final tomographic information, a clear tomographic image can be obtained. Will be able to.
  • a part of the light output from the light source 61 is irradiated to the eye EY11 through the optical fiber 81, the collimating lens 71, the scanning unit 72, the OCT focus lens 73, and the objective lens 74 as observation light.
  • the observation light reflected by the eye EY11 enters the light receiving unit 64 via the objective lens 74, the OCT focus lens 73, the scanning unit 72, the collimating lens 71, the optical fiber 81, and the optical fiber 82.
  • the remaining part of the light output from the light source 61 branches from the optical fiber 81 to the optical fiber 82 and becomes reference light. Then, the reference light enters the optical path length adjustment unit 63 through the optical fiber 82, is reflected by the reference mirror in the optical path length adjustment unit 63, and enters the optical fiber 82 again. Further, the reference light that has entered the optical fiber 82 from the optical path length adjustment unit 63 passes through the optical fiber 82 and enters the light receiving unit 64.
  • step S11 the control unit 33 determines the tomographic image acquisition range and the OCT focusing position.
  • control unit 33 determines whether the OCT in-focus position is a tomographic image based on information indicating a tomographic plane designated by an operator or the like supplied from the interface unit 32 or a recognition result supplied from the image recognition unit 31.
  • the tomographic image acquisition range and the OCT focusing position are determined so as to be located within the acquisition range.
  • step S12 the control unit 33 controls the scanning unit 72, which is a scanning system, based on the tomographic image acquisition range determined in step S11.
  • control unit 33 controls the scanning unit 72 to set the scan mirror 111 in a predetermined manner so that the observation light is irradiated to the region of the tomographic image acquisition range determined in step S11 in the eye EY11 in the XY direction (XY plane). Rotate (rotate) the angle.
  • step S13 the control unit 33 controls the optical path length adjustment unit 63 based on the tomographic image acquisition range determined in step S11 to adjust the optical path length of the reference arm.
  • the control unit 33 drives the drive unit so that the actual tomographic image acquisition range is the tomographic image acquisition range determined in step S11 in the Z direction.
  • the reference mirror 202 is moved by controlling 203.
  • the control unit 33 sets the actual tomographic image acquisition range in the Z direction to be the tomographic image acquisition range determined in step S ⁇ b> 11.
  • a voltage is applied to the delay line 231 to adjust the optical path length of the reference arm.
  • step S12 and step S13 the tomographic image acquisition range determined in step S11 is set as the acquisition target region of the tomographic image (tomographic information), and the tomographic information is acquired.
  • step S14 the control unit 33 controls the OCT focus lens 73 based on the OCT focusing position determined in step S11.
  • control unit 33 changes the refractive power of the OCT focus lens 73 by applying a voltage signal determined with respect to the OCT focus position determined in step S11 to the OCT focus lens 73.
  • the observation light is condensed at the OCT in-focus position determined in step S11.
  • step S15 the image information acquisition unit 21 acquires tomographic information.
  • the observation light is irradiated on the tomographic image acquisition range determined in step S11 and reflected within the tomographic image acquisition range, and the reference light reflected by the optical path length adjustment unit 63 and Is incident on the light receiving portion 64.
  • the light receiving unit 64 receives incident observation light and reference light, performs photoelectric conversion, and outputs the tomographic information obtained as a result.
  • the image information acquisition unit 21 acquires the tomographic information output from the light receiving unit 64 in this way. Further, the image information acquisition unit 21 constructs (generates) a tomographic image and volume data from the tomographic information obtained in each of a plurality of tomographic image acquisition ranges as necessary, and the image recognition unit 31 and the display information generation unit 34. To supply.
  • step S16 the control unit 33 determines whether to end the acquisition of tomographic information.
  • step S16 If it is determined in step S16 that the acquisition of tomographic information has not been completed yet, the process returns to step S11, and the above-described process is repeated.
  • the new region is taken as the tomographic image acquisition range and the tomographic information is obtained. That is, the tomographic information is acquired by shifting the tomographic image acquisition range.
  • step S16 when it is determined in step S16 that the acquisition of tomographic information is to be terminated, each part of the surgical microscope system 11 stops the operation for acquiring the tomographic information, and the tomographic information acquiring process is ended.
  • the surgical microscope system 11 determines the OCT focusing position and the tomographic image acquisition range, and acquires tomographic information according to the determination.
  • a clear tomographic image can be obtained by controlling the OCT focusing position and the adjustment of the tomographic image acquisition range in conjunction with each other.
  • the optical path length of the reference arm is adjusted by adjusting the optical path length of the reference arm, thereby adjusting the range (region) in the Z direction as the acquisition target of the tomographic information.
  • the optical path length adjusting unit 63 can be arranged outside the microscope barrel 65. Thereby, the microscope barrel 65 can be reduced in size while adjusting the Z direction of the tomographic image acquisition range at high speed.
  • the above-described series of processing can be executed by hardware or can be executed by software.
  • a program constituting the software is installed in the computer.
  • the computer includes, for example, a general-purpose personal computer capable of executing various functions by installing a computer incorporated in dedicated hardware and various programs.
  • FIG. 7 is a block diagram showing an example of the hardware configuration of a computer that executes the above-described series of processing by a program.
  • a CPU Central Processing Unit
  • ROM Read Only Memory
  • RAM Random Access Memory
  • An input / output interface 505 is further connected to the bus 504.
  • An input unit 506, an output unit 507, a recording unit 508, a communication unit 509, and a drive 510 are connected to the input / output interface 505.
  • the input unit 506 includes a keyboard, a mouse, a microphone, an image sensor, and the like.
  • the output unit 507 includes a display, a speaker, and the like.
  • the recording unit 508 includes a hard disk, a nonvolatile memory, and the like.
  • the communication unit 509 includes a network interface or the like.
  • the drive 510 drives a removable recording medium 511 such as a magnetic disk, an optical disk, a magneto-optical disk, or a semiconductor memory.
  • the CPU 501 loads the program recorded in the recording unit 508 to the RAM 503 via the input / output interface 505 and the bus 504 and executes the program, for example. Is performed.
  • the program executed by the computer (CPU 501) can be provided by being recorded in a removable recording medium 511 as a package medium, for example.
  • the program can be provided via a wired or wireless transmission medium such as a local area network, the Internet, or digital satellite broadcasting.
  • the program can be installed in the recording unit 508 via the input / output interface 505 by attaching the removable recording medium 511 to the drive 510. Further, the program can be received by the communication unit 509 via a wired or wireless transmission medium and installed in the recording unit 508. In addition, the program can be installed in the ROM 502 or the recording unit 508 in advance.
  • the program executed by the computer may be a program that is processed in time series in the order described in this specification, or in parallel or at a necessary timing such as when a call is made. It may be a program for processing.
  • the present technology can take a cloud computing configuration in which one function is shared by a plurality of devices via a network and is jointly processed.
  • each step described in the above flowchart can be executed by one device or can be shared by a plurality of devices.
  • the plurality of processes included in the one step can be executed by being shared by a plurality of apparatuses in addition to being executed by one apparatus.
  • the present technology can be configured as follows.
  • the tomographic information acquisition optical system includes an optical path length adjustment unit that adjusts an optical path length of the reference light.
  • the said optical path length adjustment part is a surgery microscope system as described in (1) arrange
  • the optical path length adjustment unit includes a mirror arranged on the optical path of the reference light and having a variable arrangement position, and adjusts the optical path length of the reference light by changing the arrangement position of the mirror.
  • 11 surgical microscope system 21 image information acquisition unit, 33 control unit, 61 light source, 62 coupler, 63 optical path length adjustment unit, 64 light receiving unit, 65 microscope barrel, 72 scanning unit, 73 OCT focus lens, 74 objective lens , 75 microscope optical system, 101 tomographic information acquisition optical system

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

La présente technique concerne un système de microscope chirurgical qui permet de réduire la taille d'un tube de microscope. Ce système de microscope chirurgical comprend : un système optique de microscope pour observer un tissu biologique qui est un objet à observer; et un système optique d'acquisition d'informations tomographiques pour acquérir des informations tomographiques du tissu biologique utilisant une interférence entre la réflexion de la lumière d'observation qui est émise sur le tissu biologique et la lumière de référence qui n'est pas émise sur le tissu biologique. Le système optique d'acquisition d'informations tomographiques a une unité de réglage de longueur de trajet optique qui ajuste une longueur de trajet optique de la lumière de référence. Cette technique peut être appliquée à un système de microscope chirurgical.
PCT/JP2019/009267 2018-03-22 2019-03-08 Système de microscope chirurgical WO2019181553A1 (fr)

Applications Claiming Priority (2)

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JP2018-054228 2018-03-22
JP2018054228 2018-03-22

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WO2019181553A1 true WO2019181553A1 (fr) 2019-09-26

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023517598A (ja) * 2020-03-10 2023-04-26 ライカ マイクロシステムズ インコーポレイテッド 統合された撮像システムを有する手術用顕微鏡の光学系を最適化するためのシステム、方法、およびコンピュータプログラム製品

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090279052A1 (en) * 2008-05-07 2009-11-12 Christoph Hauger Ophthalmologic surgical microscope system having an OCT-measuring device
JP2014115161A (ja) * 2012-12-07 2014-06-26 Nippon Telegr & Teleph Corp <Ntt> 動的焦点移動型光干渉断層顕微鏡
JP2015102537A (ja) * 2013-11-28 2015-06-04 キヤノン株式会社 光干渉断層計

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090279052A1 (en) * 2008-05-07 2009-11-12 Christoph Hauger Ophthalmologic surgical microscope system having an OCT-measuring device
JP2014115161A (ja) * 2012-12-07 2014-06-26 Nippon Telegr & Teleph Corp <Ntt> 動的焦点移動型光干渉断層顕微鏡
JP2015102537A (ja) * 2013-11-28 2015-06-04 キヤノン株式会社 光干渉断層計

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023517598A (ja) * 2020-03-10 2023-04-26 ライカ マイクロシステムズ インコーポレイテッド 統合された撮像システムを有する手術用顕微鏡の光学系を最適化するためのシステム、方法、およびコンピュータプログラム製品

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