WO2019180031A1 - Procédé de production et d'utilisation d'un substrat présentant une surface fonctionnalisée - Google Patents

Procédé de production et d'utilisation d'un substrat présentant une surface fonctionnalisée Download PDF

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Publication number
WO2019180031A1
WO2019180031A1 PCT/EP2019/056862 EP2019056862W WO2019180031A1 WO 2019180031 A1 WO2019180031 A1 WO 2019180031A1 EP 2019056862 W EP2019056862 W EP 2019056862W WO 2019180031 A1 WO2019180031 A1 WO 2019180031A1
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
liquid
stamp
layer
structures
Prior art date
Application number
PCT/EP2019/056862
Other languages
German (de)
English (en)
Inventor
Sven SCHRÖDER
Nadja Felde
Luisa Coriand
Anna GÄRTNER
Jens Eberhardt
Gunther Notni
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
Friedrich-Schiller-Universität Jena
Als Automated Lab Solutions Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V., Friedrich-Schiller-Universität Jena, Als Automated Lab Solutions Gmbh filed Critical Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
Publication of WO2019180031A1 publication Critical patent/WO2019180031A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/00365—Production of microlenses
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/0006—Arrays
    • G02B3/0012—Arrays characterised by the manufacturing method
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/00432—Auxiliary operations, e.g. machines for filling the moulds
    • B29D11/00442—Curing the lens material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures

Definitions

  • the invention relates to a method for producing a substrate having a functionalized surface, wherein the functionalized surface in particular has selectively wettable areas with a liquid. Furthermore, a method of using the liquid drop generating substrate will be described.
  • liquid droplets should wet areas of the surface of the substrate that are defined with a biological substance contained therein,
  • liquid drops for example, for the separation of cells.
  • the application of the liquid drops can be done by targeted placement of the liquid drops by means of a syringe or pipette on the substrate.
  • a syringe or pipette on the substrate.
  • this is very expensive if a very large number of liquid drops to be applied to defined areas of a substrate.
  • the invention has for its object to provide a method for producing a substrate having a functionalized surface, with the most effective and
  • Inexpensive selectively wettable areas can be produced on the surface of the substrate. Furthermore, a should Process for the production of liquid drops under
  • a substrate which may comprise, for example, a glass, a plastic, a metal or a semiconductor material.
  • a stamp is applied to the substrate having an array of structures to mask defined areas of the substrate.
  • the stamp can be attached to the substrate by clamping, for example.
  • stamps which define the areas masked by the stamp are advantageously freely selectable.
  • the stamp can, for example, by means of 3D printing or alternatively by a structuring method such as embossing or
  • the stamp can be advantageously reused to produce a variety of similar substrates. After application of the stamp, the method becomes a hydrophobic layer outside the areas masked by the stamp
  • the surface of the substrate becomes
  • the unmasked areas have a water-repellent property due to the applied hydrophobic layer, while in the masked areas the substrate surface or a surface area of the masked areas
  • Substrate applied layer is exposed. In these previously masked areas, the substrate or the
  • the stamp preferably has a grid arrangement of
  • the structures may be identical if a plurality of identical wettable regions are to be formed on the substrate.
  • Stamps are preferably separated from each other
  • the geometric shapes may be, for example, circular areas, but any other geometric shapes are conceivable. Of the
  • a stamp can be an arrangement of a plurality of structures of similar geometric shapes
  • the stamp preferably has structures whose size is in the micrometer or millimeter range. According to
  • the stamp has structures with widths between 1 ym and 10 mm.
  • the hydrophobic layer is applied by a wet-chemical method.
  • the wet-chemical application of the hydrophobic layer is particularly advantageous, since in this case a possible partial shading of the substrate surface by the stamp, which in a vacuum coating process could be problematic, not disturbing.
  • the hydrophobic layer by a
  • the hydrophobic layer is a fluoropolymer, in particular a fluoroalkylsilane or a fluoropolyether.
  • fluoropolymers are characterized in particular by their water-repellent properties.
  • a hydrophilic layer is applied to the substrate before the application of the stamp.
  • the hydrophilic layer can be any hydrophilic layer.
  • the hydrophilic layer is not masked in the structures of the stamp
  • Stamp thus has a hydrophilic property in the areas previously masked by the structures of the stamp and in the areas outside thereof
  • the hydrophilic layer may in particular be an oxide layer.
  • the hydrophilic layer may include TiO 2, ZrO 2, SiO 2 or Al 2 O 3.
  • the application of the hydrophilic layer can be carried out, for example, with a sol-gel method
  • the hydrophilic layer is a metal layer.
  • the hydrophilic layer has a nanostructure or is in the Process provided with a nanostructure. It is for example possible that the hydrophilic layer
  • the hydrophilic layer is first deposited as a smooth layer and then roughened by a post-treatment.
  • the after-treatment may in particular be a chemical and / or thermal aftertreatment.
  • the hydrophilic layer by a
  • the hydrophilic layer may be an A 1 C 2 layer, particularly with a sol-gel method
  • a hydrophilic nanostructure can be produced on the surface by means of a thermal after-treatment, for example by a treatment in boiling water.
  • the nanostructure of the hydrophilic layer has an rms roughness (root mean squared roughness) of 1 nm to 50 nm.
  • the contact angle of a liquid applied to the substrate can be adjusted specifically. In this way, liquid droplets with different curvatures, in particular different aspect ratios, can be produced.
  • the method for producing liquid drops according to the invention provides a substrate having a functionalized surface which can be produced according to the method steps described above.
  • a liquid is applied to the substrate, wherein the liquid forms separated liquid droplets in areas that are not covered by the hydrophobic layer.
  • the liquid advantageously wets only those areas of the substrate in which the substrate surface or one on the substrate
  • Liquid applied by immersing the substrate in the liquid Due to the surface functionalization of the substrate can be particularly simple and inexpensive liquid droplets on the surface of the substrate
  • Substrate are generated. In particular, it is not
  • Solidified liquid drop to solids The shape of the solids produced in this way is advantageously determined by the wetting properties of the functionalized substrate.
  • the liquid drops it is possible for the liquid drops to be hardened into microlenses.
  • the diameter of the liquid drops it is possible for the liquid drops to be hardened into microlenses.
  • microlenses correspond to the diameters of the structures of the stamp used in the manufacture of the invention
  • Substrate is used. Furthermore, the radius of curvature of the microlenses due to the material properties of
  • the procedure allows in particular, on comparatively simple way to produce a plurality of preferably identical microlenses.
  • the hardening of the liquid drops is preferably carried out by a thermal
  • the liquid may in particular comprise a UV-curable polymer.
  • the UV-curable polymer may in particular be an organic
  • Polymers are available, for example, under the names Ormocer and Ormocomp.
  • FIG. 1 shows a schematic representation of a substrate that can be produced by the method
  • FIG. 2 shows an example of a stamp that can be used in the method.
  • FIGS. 3 to 7 each show a schematic representation of a cross section through a region of the substrate
  • FIG. 1 shows an exemplary embodiment of the substrate 1 which has been provided with a surface functionalization by the method according to the invention.
  • Substrate 1 may comprise any substrate material, for example a glass, a plastic
  • the substrate 1 Semiconductor material or a metal.
  • a hydrophobic layer 2 On the surface of the substrate 1 areas are covered with a hydrophobic layer 2. Furthermore, the substrate 1 has areas in which the substrate surface 1A is exposed. Alternatively, it would also be possible that, instead of the substrate surface 1A, a hydrophilic layer previously applied to the substrate 1 is exposed. The areas of the substrate 1 not covered by the hydrophobic layer 2 are produced in the method by means of a stamp.
  • FIG. 2 shows an example of the stamp 10.
  • the stamp 10 has a plurality of structures 11, wherein the structures 11 may be arranged, for example, in a grid arrangement.
  • the structures 11 each have a circular shape, but any other geometric shapes for the structures 11 of the stamp 10 are also conceivable.
  • the structures 11 of the stamp preferably have widths between 1 and 10 mm.
  • the structures 11 of the stamp are used in the method for
  • the stamp 10 is applied to the substrate 1 and subsequently the hydrophobic layer 2 is applied outside the areas masked by the stamp 10.
  • the application of the hydrophobic layer 2 may for example by a
  • the punch 10 can be used, for example, with a
  • the stamp 10 can be advantageously reused in the method, so that a plurality of substrates 1 with the
  • the stamp 10 may, for example, by 3D printing or by a structuring method such
  • embossing or lithography are produced.
  • Figure 3 shows schematically a portion of a substrate 1 made according to an example of the method.
  • a portion of the substrate 1 is a
  • hydrophobic layer 2 has been applied, wherein the hydrophobic layer 2 has recesses in which the
  • Substrate surface 1A is exposed.
  • the exposed areas correspond to the structures 11 of the stamp, with which in the production of the hydrophobic layer 2, the substrate 1
  • the hydrophobic layer 2 may, in particular, be a fluoropolymer such as, for example
  • Fluoroalkylsilane or a fluoropolyether Fluoroalkylsilane or a fluoropolyether.
  • hydrophobic layer 2 outside the structures of the stamp can, for example, by wet chemical
  • FIG. 3 also shows a liquid drop 4 in the application of the substrate 1. Since the hydrophobic layer 2 water-repellent properties, are in the
  • Substrate 1 only covers the non-covered by the hydrophobic layer 2 areas, that is through the
  • Substrate surface 1A and so the shape of the liquid droplets 4 are set specifically.
  • the liquid can be used for
  • Example be applied by dipping the substrate 1 in the liquid, wherein the liquid
  • Substrate surface 1A wetted only outside the hydrophobic layer 2 and from the hydrophobic layer 2 covered areas of the substrate 1 rolls off or rolls.
  • the liquid can also be applied by spraying, dripping, spraying or knife coating, wherein
  • the volume of the liquid phase can be controlled.
  • the liquid may include, for example, water, oil, solvent, paint, an electrically conductive material, an adhesive or other compound.
  • the liquid 4 is a
  • Substrate 1 is applied and then cured, for example by thermal or UV-based
  • FIG. 4 shows a region of the substrate 1 in a further example of the method.
  • a hydrophilic layer 3 has been applied over the whole area to the surface of the substrate 1.
  • the hydrophilic layer 3 is preferably one
  • Oxide layer is for example by a wet
  • the stamp is applied to the substrate and subsequently, as in the previous example, the hydrophobic layer 2 outside of the
  • FIG. 5 shows a region of the substrate 1 produced by a further example of the method.
  • a hydrophilic layer 3 is used
  • the hydrophilic layer 3 has been provided with a nanostructure 30 in a further step. As with the previous one
  • the regions of the hydrophilic layer 3 outside the regions masked by the structures of the stamp have been overcoated with the hydrophobic layer 2.
  • the thickness of the hydrophobic layer 2 is advantageously so low in this example that the roughness of the nanostructure does not substantially change.
  • the hydrophilic layer 3 can be, for example, an Al 2 O 3 layer, in which the nanostructure 30 can be produced in a comparatively simple manner by a thermal treatment, in particular in boiling water.
  • Nanostructure 30 in the hydrophilic layer 3 can alternatively also be effected by other methods, for example by chemical or plasma-based etching methods. Furthermore, it is also possible for the hydrophilic layer to have nanoparticles which cause the hydrophilic layer 3 to have a nanostructure 30 on the surface after production.
  • the nanostructure 30 preferably has an rms surface roughness between 1 nm and 50 nm.
  • the roughness of the surface of the hydrophilic layer offers, in addition to the intrinsic material properties, an additional
  • structures in the nanometer range are suitable for avoiding stray light.
  • stochastic roughness structures in the nanometer range are perfectly adequate for the functional effect.
  • the wetting behavior of the hydrophilic layer 3 with the nanostructures 30 can be determined in particular via the
  • FIG. 6 shows a modification of the previous example in which the aspect ratio of the nanostructures 30 has been increased.
  • the nanostructures 30 have a height d2 that is greater than the height dl of the nanostructures in the previous example.
  • the shape of the liquid drop 4 changes, for example, becomes a flatter shape of the Liquid drop achieved.
  • the liquid is a curable liquid used to produce microlenses, the radius of curvature of the microlenses can be influenced in a targeted manner in this way.
  • the liquid droplet 4 has a volume V2 that is greater than the volume VI in the example of FIG. 5.
  • V2 volume of the liquid droplet 4
  • the contact angle of the liquid droplet 4 can be changed.
  • the method can also be advantageously used for the distribution of biological substances in biomedical applications.

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  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Mechanical Engineering (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Micromachines (AREA)

Abstract

L'invention concerne un procédé de fabrication d'un substrat présentant une surface fonctionnalisée, dans lequel on applique sur le substrat (1) un tampon (10) ayant un réseau de structures (11) pour fabriquer des zones masquées. Ensuite, une couche hydrophobe (2) est appliquée à l'extérieur des zones masquées par les structures (11) du poinçon (10) et le poinçon (10) est à nouveau enlevé. L'invention concerne également un procédé, dans lequel un substrat (1) produit de cette manière est utilisé pour produire des gouttelettes liquides (4).
PCT/EP2019/056862 2018-03-21 2019-03-19 Procédé de production et d'utilisation d'un substrat présentant une surface fonctionnalisée WO2019180031A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018106707.0 2018-03-21
DE102018106707.0A DE102018106707A1 (de) 2018-03-21 2018-03-21 Verfahren zur Herstellung und Verwendung eines Substrats mit einer funktionalisierten Oberfläche

Publications (1)

Publication Number Publication Date
WO2019180031A1 true WO2019180031A1 (fr) 2019-09-26

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DE (1) DE102018106707A1 (fr)
WO (1) WO2019180031A1 (fr)

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Publication number Priority date Publication date Assignee Title
AT523356B1 (de) * 2019-12-23 2021-12-15 Viewpointsystem Gmbh Verfahren zur herstellung wenigstens einer optischen linse
US20230229075A1 (en) * 2020-06-16 2023-07-20 Nilt Switzerland Gmbh Surface treatment for replication

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP1160262A1 (fr) * 2000-05-10 2001-12-05 Symyx Technologies, Inc. Bibliothèques de polymères sur un substrat, méthode de préparation des bibliothèques de polymères sur un substrat et procédés de caractérisation permettant d'utiliser ces bibliothèques

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Publication number Priority date Publication date Assignee Title
US5627079A (en) * 1989-03-27 1997-05-06 The Research Foundation Of State University Of New York Refunctionalized oxyfluorinated surfaces
DE19814805A1 (de) * 1998-04-02 1999-10-07 Bosch Gmbh Robert Beschichtungsverfahren eines Wischergummis
DE10100383A1 (de) * 2001-01-05 2002-07-11 Degussa Verfahren zur Aufbringung einer fluoralkylfunktionellen Organopolysiloxan-Beschichtung mit beständigen Wasser und Öl abweisenden Eigenschaften auf polymere Substrate
DE10139924A1 (de) * 2001-08-14 2003-03-13 Hans-Juergen Butt Verfahren zum Herstellen von Lichtstreukörpern

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP1160262A1 (fr) * 2000-05-10 2001-12-05 Symyx Technologies, Inc. Bibliothèques de polymères sur un substrat, méthode de préparation des bibliothèques de polymères sur un substrat et procédés de caractérisation permettant d'utiliser ces bibliothèques

Non-Patent Citations (1)

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Title
N. N.: "4 kreative Techniken mit Ölfarben", 20 October 2016 (2016-10-20), XP055599064, Retrieved from the Internet <URL:https://web.archive.org/web/20170909222131/https://www.oelbilder-oelmalerei.de/4-kreative-techniken-mit-olfarben/> [retrieved on 20190624] *

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