WO2019175739A1 - Aliments pour l'amélioration de la santé et des performances de mammifères - Google Patents

Aliments pour l'amélioration de la santé et des performances de mammifères Download PDF

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Publication number
WO2019175739A1
WO2019175739A1 PCT/IB2019/051941 IB2019051941W WO2019175739A1 WO 2019175739 A1 WO2019175739 A1 WO 2019175739A1 IB 2019051941 W IB2019051941 W IB 2019051941W WO 2019175739 A1 WO2019175739 A1 WO 2019175739A1
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Prior art keywords
high intensity
feed
intensity sweetener
mammals
ppm
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PCT/IB2019/051941
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English (en)
Inventor
Emma WALL
Original Assignee
Pancosma Sa
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Filing date
Publication date
Application filed by Pancosma Sa filed Critical Pancosma Sa
Priority to CN201980013368.2A priority Critical patent/CN111867400A/zh
Priority to EP19715223.4A priority patent/EP3764817A1/fr
Publication of WO2019175739A1 publication Critical patent/WO2019175739A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents

Definitions

  • This invention relates to feeds and feed additives containing a high intensity sweetener and/or capsicum oleoresin and their use to improve health and performance of mammals.
  • Enteritis is an infection of the digestive tract that can be caused by a variety of different pathogens. In rabbits, enteritis is a devastating disease that accounts for the majority of illnesses, deaths, and economic losses. Young and recently-weaned rabbits are especially susceptible and the primary symptom is diarrhea, combined with a decrease in growth and performance. Colibacillosis is enteritis caused by the bacterial pathogen Escherichia coli (E. Coii), which in rabbits infects both the small intestine and the cecum. Colibacillosis is very common in young rabbits and mortality rates can be very high; the disease can be passed from the doe to the kits with often the entire litter impacted by the sickness.
  • E. Coii bacterial pathogen Escherichia coli
  • Phytonutrients are naturally-occurring bioactive chemicals found in plants. In monogastric species, supplementation of the feed with the phytonutrient capsicum oleoresin has been shown to mitigate oxidative stress (Karadas et al., 2014. Br Poult Sci. 55: 329-334) and prevent disease symptoms (Liu et al ., 2012. J Anim Sci. 90: 2774-2783, Lee et al., 2013. Br J Nutr. 110: 840-847, Liu et al., 2013. J Anim Sci. 91: 5668-5679, Liu et al., 2013. J Anim Sci. 91: 5294-5306) by enhancing immunity.
  • Capsicum oleoresin has also been shown to improve gut health during normal and disease conditions (Liu et al., 2014. J Anim Sci. 92: 3426-3440, Liu et al., 2014. J Anim Sci. 92: 2050-2062).
  • GLP-2 glucagon-like peptide
  • the effective doses vary but normally range between 20 and 400 ppm for phytonutrients and >200 ppm for high intensity artificial and natural sweeteners (Moran et al., 2010. Br J Nutr. 104: 637-646, Moran et al., 2014. J Dairy Sci. 97: 4955-4972, Ponce et al., 2014. J Anim Sci. 92: 1630- 1638, Siurana et al., 2014. J. Dairy Sci. 97 (E-Suppl. 1): 811 (Abstr.), Connor et al., 2017. J Dairy Sci. 100: 3004-3018). Often even higher doses of these molecules are used especially for phytonutrients which are often used for their anti-microbial properties. The doses used depend on the species, molecules tested and the objectives of the study.
  • the challenge addressed in the current invention is to improve the health and performance of mammals, in particular rabbits, without the use of antibiotics.
  • the inventors explored the use of high intensity artificial and natural sweetener or capsicum oleoresin fed alone and in combination.
  • doses that have previously been established as beneficial in other species are in fact highly detrimental in rabbits.
  • the current invention therefore introduces a novel approach using additives to decrease the negative impact of enteritis in rabbits.
  • a combination of the two additives is used for synergistic effects on health (decreased morbidity - including diarrhea and bloat - and mortality) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of rabbits.
  • a range of specific ratios of high intensity sweetener to capsicum oleoresin is used for synergistic effects on health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of rabbits.
  • a combination of high intensity sweetener and capsicum oleoresin when supplemented at very low doses, improves zootechnical performance of other mammals including calves and piglets.
  • the invention relates to a feed including:
  • At least one artificial high intensity sweetener in an amount greater than zero and less than or equal to 50 ppm; or - at least one natural high intensity sweetener in an amount greater than zero and less than or equal to 180 ppm.
  • the invention pertains to a feed including capsicum oleoresin in an amount greater than zero and less than or equal to 2 ppm.
  • the invention relates to a feed additive including at least one high intensity artificial or natural sweetener and capsicum oleoresin, wherein the weight ratio of high intensity sweetener to capsicum oleoresin is less than 100:1 and preferably less than or equal to 25:1.
  • SW artificial high intensity sweetener
  • SWN natural high intensity sweetener
  • CO capsicum oleoresin
  • SW artificial high intensity sweetener
  • SWN natural high intensity sweetener
  • CO capsicum oleoresin
  • SWN high intensity sweetener
  • CO capsicum oleoresin
  • Figure 4 illustrates that an optimal weight ratio between natural high intensity sweetener (SWN) and capsicum oleoresin (CO) is shown by a linear decrease in morbidity in rabbits inoculated with Escherichia coli.
  • Figure 7 shows that a supplement including natural high intensity sweetener (SWN) at 26 ppm and capsicum oleoresin (CO) at 2 ppm is efficient at decreasing veterinary treatments in calves.
  • SWN natural high intensity sweetener
  • CO capsicum oleoresin
  • Figure 8 shows that a supplement including natural high intensity sweetener (SWN) at 30 ppm and capsicum oleoresin (CO) at 2 ppm is efficient at increasing body weight in piglets.
  • SWN natural high intensity sweetener
  • CO capsicum oleoresin
  • feed additive is herein meant an additive which is not aimed at being used alone but added to the usual ingredients of a conventional feed of the mammal.
  • final feed is herein meant the feed obtained after the addition of the feed additive of the invention and ready to be fed to the mammal.
  • This invention proposes a novel approach for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) in mammals including rabbits, swine, and calves by using low doses of a high intensity sweetener, capsicum oleoresin, or a combination of the two.
  • This invention may be used during normal rearing conditions or during phases where enteritis may be present.
  • enteritis By enteritis, the inventors refer to any inflammation of the gastrointestinal tract of mammals, no matter what the causative agent (including but not limited to: coccidiosis, enterotoxemia, colibacillosis, mucoid enteritis, proliferative enteropathy, or Tyzzer's disease).
  • the high intensity sweetener can be a high intensity artificial sweetener, a high intensity natural sweetener, or their combinations.
  • the high intensity artificial sweetener used for this invention may include and is not limited to: saccharin and its salts, acesulfame-K, cyclamate, aspartame, sucralose, neotame, advantame alone or in combination.
  • the high intensity artificial sweetener may also include a potentiator.
  • the high intensity artificial sweetener includes at least 96wt% sodium saccharinate, and at least 0.2wt% neohesperidin dihydrochalcone (NH DC).
  • the dose of artificial high intensity sweetener used in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) in rabbits includes all doses that are ⁇ 50 ppm in the final feed.
  • the high intensity natural sweetener used for this invention may include and is not limited to: stevia leaf, stevia extracts, steviosides including steviol glycosides, rebaudioside A, rebaudioside C, dulcoside A, rubusoside, steviolbiosode, rebaudioside B, or any other high intensity sweetener from natural origin alone or in combination.
  • the high intensity sweetener from natural origin can also originate from the flowing plants and/or their extracts and/or active compounds: Pentadiplandra brazzeana (pentadina and brazzein), lllicium verum, Piper marginatum or Myrrhis odorata (trans-anethole and estragole), Osmorhiza longistylis (anethole), Citrus paradis (naringin), Hydrangea macrophylla (dihydro-coumarin).
  • the high intensity natural sweetener may also include a potentiator.
  • the high intensity natural sweetener used includes at least 75wt% steviol glycosides (at least 25wt% of which was rebaudioside A), and also a potentiator: at least 0.3wt% ammonium glycyrrhizinate.
  • the potentiator included in the high intensity artificial or natural sweetener may be selected from the list including but not limited to: glycyrrhizin, ammonium glycyrrhizinate, potassium glycyrrhizinate, sodium glycyrrhizinate, thaumatin, kokumi, NHDC, ribotides, sodium glutamate.
  • very low doses of high intensity natural sweetener were discovered to be beneficial for health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of rabbits.
  • the inventors first tested a dose that made sense based on the state of the art as this dose had been previously established as beneficial for other small mammals (360 ppm in the feed). Surprisingly, the inventors found that in rabbits this dose was highly detrimental because it greatly increased mortality during an enteritis challenge. Next, the inventors tested a new lower dose of 180 ppm supplemented to rabbits, followed by an enteritis challenge and it was discovered that mortality was greatly reduced at this low dose.
  • the dose of high intensity natural sweetener used in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth and feed efficiencies) in rabbits includes all doses that are ⁇ 200 ppm and preferably ⁇ 180 in the final feed.
  • the capsicum used for this invention may include and is not limited to: capsicum oleoresin that is plant- derived (natural) or any product containing at least 6wt% capsaicinoids (capsaicin and dihydrocapsaicin).
  • capsicum oleoresin was supplemented as a product that was manufactured using capsicum oleoresin (22wt%) incorporated into a matrix of 78wt% rape seed oil (via spray cooling), the method that is described in document EP2088871 (US20100055253; W02008062368).
  • the final encapsulated product contained 20wt% capsicum oleoresin.
  • capsicum oleoresin were discovered to be beneficial for health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of rabbits.
  • the inventors first tested a dose (4 ppm in the feed) that had been previously established as beneficial for other small mammals, and found that in rabbits it was detrimental because it increased mortality during an enteritis and/or colibacillosis challenge.
  • the inventors tested a new lower dose of 2 ppm supplemented to rabbits, followed by an enteritis challenge and it was discovered that mortality was greatly reduced at this low dose.
  • the dose of capsicum oleoresin used in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) in rabbits includes all doses that are ⁇ 2 ppm in the final feed.
  • the dose of a mixture of high intensity sweetener and capsicum oleoresin used in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) in rabbits includes all doses that are ⁇ 200 ppm and preferably ⁇ 180 ppm of high intensity sweetener and ⁇ 2 ppm of capsicum oleoresin in the final feed (weight ratio of high intensity sweetener: capsicum oleoresin ⁇ 100:1 and preferably ⁇ 25:1).
  • the dose of a mixture of high intensity artificial sweetener and capsicum oleoresin used in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) in rabbits includes all doses that are ⁇ 100 ppm and preferably ⁇ 50 ppm of high intensity artificial sweetener and ⁇ 2 ppm of capsicum oleoresin in the final feed (weight ratio of high intensity artificial sweetener: capsicum oleoresin ⁇ 50:1 and preferably ⁇ 25:1).
  • the inventors then tested the use of such low doses of high intensity sweetener and capsicum oleoresin fed in combination to other mammals including swine and calves. In both cases, the low doses fed improved digestive health and zootechnical performance.
  • the dose of a mixture of high intensity natural sweetener and capsicum oleoresin used in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of mammals includes all doses that are ⁇ 200 ppm and preferably ⁇ 180 ppm of high intensity natural sweetener and ⁇ 2 ppm of capsicum oleoresin in the final feed (weight ratio of high intensity artificial sweetener: capsicum oleoresin ⁇ 100:1 and preferably ⁇ 25:1).
  • the examples provided in this invention include weight ratios of natural high intensity sweetener: capsicum oleoresin of 12.5:1, 45:1, 90:1 (Example 2), 11.5:1 (Example 3), 13:1 (Example 4) and 15:1 (Example 5).
  • the product including high intensity sweetener and capsicum oleoresin that was created in this invention contains up to 66wt% stevia extract (comprising at least 75wt% steviol glycosides of which at least 25wt% is rebaudioside A) and up to 3wt% capsicum oleoresin (containing at least 6wt% capsaicinoids (capsaicin and dihydrocapsaicin)).
  • the final product includes >49wt% steviol glycosides, >12wt% rebaudioside A, and >0.18wt% capsaicinoids. It also includes up to 3wt% NHDC and up to 3wt% Glycyrrhizin NH 3 .
  • the product may include some technological agents such as arabic gum, modified starch, maltodextrin, etc.
  • the product can be obtained via standard atomization technologies (e.g. fluidized bed spray granulation, spray drying, etc.).
  • the effective dose of the product including high intensity sweetener and capsicum oleoresin that was created in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of mammals includes all doses that are ⁇ 100 ppm in the final feed.
  • the effective dose of the product including high intensity artificial sweetener and capsicum oleoresin that was created in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of mammals includes all doses that are ⁇ 100 ppm in the final feed.
  • the effective dose of the product including high intensity natural sweetener and capsicum oleoresin that was created in this invention for improving health (decreased mortality - including diarrhea and bloat - and morbidity) and performance (increased intake, daily gains and/or improved growth or feed efficiencies) of mammals includes all doses that are ⁇ 100 ppm in the final feed.
  • the analysis of high intensity natural sweetener in the product created in this invention can be quantified through steviol glycoside levels using high performance liquid chromatography (HPLC).
  • capsicum oleoresin in the product created in this invention can be quantified through capsaicinoid levels (capsaicin and dihydrocapsaicin) using HPLC or gas chromatography.
  • capsaicinoid levels capsaicin and dihydrocapsaicin
  • Rabbits were assigned to supplementation with no additive (control), 150 ppm of an high intensity artificial sweetener (SW) containing at least 96wt% sodium saccharine, NHDC, and maltodextrin; 360 ppm of a high intensity natural sweetener (SWN) containing at least 70wt% steviosides, ammonium glycyrrhizinate, and maltodextrin; or 4 ppm of capsicum oleoresin (CO) containing at least 6wt% capsaicinoids.
  • SW high intensity artificial sweetener
  • SWN high intensity natural sweetener
  • CO capsicum oleoresin
  • This example is used to illustrate synergy between high intensity natural sweeteners and phytonutrients.
  • Rabbits were assigned to one of 6 dietary treatments: control or supplementation with 180 ppm of SWN of Example 1, 2ppm of CO, or 2 ppm of CO combined with various levels of SWN (23, 90, or 180 ppm) of Example 1.
  • the same enteritis challenge was utilized (rabbits were inoculated with 500 pL containing 5 x 106 CFU/mL of E. Coli inoculum from INRA) and the same parameters were measured as for Example 1.
  • SWN at 180ppm actually increased morbidities (disease symptoms including diarrhea and bloat) during disease challenge (Figure 3).
  • the third example demonstrates the effect of an optimum weight ratio of SWN:CO on rabbit health and performance when supplemented at various doses. Rabbits were assigned to control diets or
  • the fourth example demonstrates the response to calves when supplemented with a diet containing a combination of SWN and CO on intestinal health of calves.
  • Calves were assigned to control diets or diets containing 26 ppm SWN of Example 1 and 2 ppm CO.
  • the supplementation decreased the number of pens treated with electrolytes or antibiotics (Figure 7); results illustrate sensitivity of calves to the low dose of supplements fed in combination.
  • the fifth example demonstrates the effect of a combination of SWN and CO on zootechnical performance of piglets.
  • Piglets were assigned to control diets or supplementation with the 30 ppm SWN of Example 1 and 2 ppm CO.
  • the supplementation increased daily gain and final body weight (Figure 8); results illustrate sensitivity of swine to the low dose of supplement fed in combination.

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Abstract

L'invention concerne des additifs alimentaires contenant une association d'un édulcorant de haute intensité et d'oléorésine de capsicum. Plus précisément, l'invention porte sur un additif alimentaire à ajouter à un aliment afin de préparer un aliment final pour mammifères, comprenant une association d'au moins un édulcorant de haute intensité ; et d'oléorésine de capsicum ; le rapport pondéral de l'édulcorant de haute intensité à l'oléorésine de capsicum étant inférieur ou égal à 25:1. L'invention concerne également un aliment final comprenant l'additif alimentaire selon l'invention en une quantité supérieure à zéro et inférieure ou égale à 200 ppm par rapport au poids de l'aliment final total. En outre, l'invention porte sur l'utilisation de l'additif alimentaire ou de l'aliment final selon l'invention pour améliorer des performances zootechniques de mammifères, en particulier de lapins, de porcs et de veaux.
PCT/IB2019/051941 2018-03-15 2019-03-11 Aliments pour l'amélioration de la santé et des performances de mammifères WO2019175739A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201980013368.2A CN111867400A (zh) 2018-03-15 2019-03-11 用于改善哺乳动物健康和行为表现的饲料
EP19715223.4A EP3764817A1 (fr) 2018-03-15 2019-03-11 Aliments pour l'amélioration de la santé et des performances de mammifères

Applications Claiming Priority (6)

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EP18020101.4 2018-03-15
EP18020101 2018-03-15
EP18020393 2018-08-20
EP18020394.5 2018-08-20
EP18020393.7 2018-08-20
EP18020394 2018-08-20

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WO2019175739A1 true WO2019175739A1 (fr) 2019-09-19

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CN115886231A (zh) * 2022-11-19 2023-04-04 浙江华康药业股份有限公司 预防缓解糖醇不耐受的甜味剂组合物及其制备方法

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