WO2019175688A1 - Ensemble pour dispositif d'injection ou de perfusion - Google Patents

Ensemble pour dispositif d'injection ou de perfusion Download PDF

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Publication number
WO2019175688A1
WO2019175688A1 PCT/IB2019/051357 IB2019051357W WO2019175688A1 WO 2019175688 A1 WO2019175688 A1 WO 2019175688A1 IB 2019051357 W IB2019051357 W IB 2019051357W WO 2019175688 A1 WO2019175688 A1 WO 2019175688A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
fluid path
septum
continuous flexible
containment
Prior art date
Application number
PCT/IB2019/051357
Other languages
English (en)
Inventor
Christian Schrul
Stefan Burren
Mario Bernhard
Bernhard Bigler
Simon Scheurer
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Priority to JP2020549705A priority Critical patent/JP2021515677A/ja
Priority to CN201980019215.9A priority patent/CN111902174B/zh
Priority to EP19710491.2A priority patent/EP3765129A1/fr
Publication of WO2019175688A1 publication Critical patent/WO2019175688A1/fr
Priority to US17/017,182 priority patent/US20210001048A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3121—Means preventing contamination of the medicament compartment of a syringe via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the assembly of the fluid path unit with the containment and the cartridge can be assembled in a sterile environment which may be cumbersome (for example in view of the visual inspection) and expensive or it is assembled in a non-sterile environment such as a clean room.
  • the device comprising the assembly of the fluid path and cartridge can be in a sterile packaging during the shelflife which is removed just before use or it is in a non-sterile packaging. In either option, a sterile connection needs to be established between the content of the cartridge and the fluid path in the containment of the fluid path unit prior to use and this is usually done in a non-sterile environment.
  • the cartridge comprises a barrel having two open ends, one of which is closed by a septum with a crimp.
  • the crimp has an end wall with a center hole and the crimp fastens the septum to a shoulder section of the barrel.
  • the end wall of the crimp partially covers the septum whereas the center hole allows for a needle (steel or plastic) to move through the center hole of the crimp and penetrate the septum.
  • the septum is protected by a barrier (for sterility) film that covers the center hole and the barrier film allows for sterilization gases to pass through the film to sterilize the surface of the septum closest to the barrier film.
  • the barrier film (for sterility) is preferably attached to the end wall of the crimp.
  • the barrier film for sterility may be a film that can be penetrated by gasses or fluids.
  • An example of such a film is a porous membrane such as Tyvek (polyethylene based) or Gore Tex (fluoropolymer based porous membrane).
  • the barrier film for sterility may also be a barrier film for gases as well, an example of such a film is a non-porous membrane made of polyester, polyamide.
  • the gas barrier properties may be enhanced by coating the film with a metal layer (aluminum for example) or by a layer of glass (SiOx).
  • Such films may be single layered or multilayered comprising alternating layers of different composition.
  • a crimp for fixating and holding a septum to a cartridge comprising an open cylindrical section made from a material that can be plastically deformed and the cylindrical section is closed by an end wall having a passage.
  • the end wall being arranged substantially perpendicular to the axis of the cylindrical section.
  • the passage is arranged such that an external needle or spike may penetrate the septum via the passage.
  • the crimp further comprises a strip that is attached to the end wall and which closes the passage, the strip being made from a flexible membrane.
  • the strip is attached and arranged with respect to the end wall of the crimp that the section of the strip covering the passage has a convex or concave shape, thus the lateral dimensions of the part of the strip closing the passage exceed the dimensions of the passage.
  • the injection or infusion device may be a patch injector, a patch pump or an autoinjector having a medicament cartridge with a septum.
  • the assembly comprises a cartridge comprising a sterile liquid medicament contained in a glass barrel and being closed by a septum fastened to the glass barrel by a crimp.
  • the barrel is made from a plastic such as polypropylene, polyethylene or a cycloolefinic polymer (COC, COP).
  • the barrel has a cylindrical portion connected to a neck portion.
  • the crimp can be a metal crimp, for example an aluminum crimp according to IS08362-3 with a center hole allowing for passage of a needle through the septum.
  • the cartridge of the assembly is inserted into the cartridge holder of the fluid path unit such that the septum of the cartridge is aligned with the passage of the fluid path containment. Furthermore the first and second continuous removable flexible strips contact each other and are sandwiched between the septum and the fluid path containment, preferably sandwiched between the end surface of the crimp of the cartridge and the wall of the containment having the passage.
  • the first continuous flexible strip has a first free end and the second continuous flexible strip has a second free end, the free ends of the first and second strip are connected to the first and second areas of the respective strips.
  • the cartridge is positioned such in the cartridge holder that the first and second free ends are arranged substantially parallel to another and are located adjacent from the passage.
  • the first and second continuous flexible strips are removable from the cartridge and fluid path containment by simultaneously pulling the first and second free ends for, or thereby, establishing a sterile connection between the opposite surface of the septum and the interior of the fluid path containment.
  • the at least one other passage may be covered with a gas permeable film allowing for the sterilization gases to enter the interior or it may be covered by a gas barrier film.
  • the interior of the containment remains sterile and is protected from the environment preferably by the second continuous strip covering the passage.
  • the second area of the second continuous flexible strip is connected to the free end of the strip by at least one U-shaped fold, preferably by two U-shaped folds.
  • the second area of the second strip may be covered by a second protective cap to protect the passage.
  • the second protective cap may be glued, heat welded, ultrasonic welded or snap fitted onto the containment, preferably onto the wall comprising the passage.
  • the first and second caps are configured to allow for the free ends of the first and second continuous flexible strips to be adjacent from the first and/or second cap, e.g. a part of the continuous flexible strip is covered by the cap whereas the free end is not covered by the cap.
  • the needle or spike of the fluid path is configured to move through the passage in the housing of the fluid path unit and to penetrate the septum of the cartridge after withdrawing both flexible continuous strips.
  • Removing the strips first establishes the sterile connection, optionally, removing the strips also activates the device, for example by activating a switch.
  • the two flexible strips are sandwiched between the cartridge and the fluid path unit and are abutting each other and are preferably compressed to each other. The compression may be supported by the resilient element acting on the cartridge holder and/or the resilient element present between the cartridge and the fluid path unit.
  • Activation by strip removal may also close the energy circuit of the device (for example by simultaneously removing an isolation foil from one or both of the battery terminals) which may be followed by activating (starting) the injection, for example by pressing a button. Or, alternatively, activation by removing the strips directly starts the injection procedure.
  • the first and/or second continuous flexible strips may serve a dual purpose of establishing the sterile connection and simultaneously closing the electrical circuitry or starting the injection.
  • Figure 5 Crimp with flexible strip connected to the end wall having a first area covering the hole and a free end connected thereto via a U-shaped fold, free end connected to crimp by adhesive tape,
  • FIG. 5a Longitudinal section of Figure 5
  • Figure 8 Crimp with flexible strip, free end releasable inserted into the first area of the strip,
  • Figure 12a Unfolded strip with cut-outs for releasable, interleaved connection
  • Figure 16 Assembly of cartridge inserted into the fluid path unit.
  • the crimp of the cartridge being covered by the first strip, the passage of the containment being covered by the second strip.
  • First and second strips directly connected to the crimp and containment,
  • a cross section of a fluid path unit (46) is shown in Figure 15, comprising a containment (36) connected to a cartridge holder (37).
  • the containment (36) and cartridge holder (37) are made as one unit, for example using injection molding of a plastic.
  • the cartridge holder may have a viewing window
  • the method for assembling the assembly of the cartridge (29) and the fluid path unit comprising the cartridge holder (37) is shown in Figure 18.
  • the cartridge (29) having the not shown first continuous flexible strip (18) attached to the crimp (1) is preferably sterilized prior to insertion into the cartridge holder, this to ensure that the outer surface (35) of the septum is sterile.
  • the cartridge (29) is aligned with the longitudinal axis of the barrel (32) towards the center of the opening (45) of the cartridge holder (37).
  • the cartridge is then inserted with the crimp (1) ahead into the cartridge holder (37) such that the free ends (8,8 ' ) of the first and second continuous flexible strips are oriented parallel and flush to another.
  • the filled cartridge with the first continuous flexible strip (18) and the fluid path unit (46) are sterilized separately before assembly.
  • the assembling of the assembly is preferably done in a non-sterile environment.
  • the crimp (1) with the first continuous flexible strip (18) is sterilized as a separate part and subsequently assembled with the cartridge comprising the septum (33) - the cartridge may be empty or filled.
  • the assembly of the crimp with the cartridge is done in a sterile environment.
  • the first and second continuous flexible strips are attached respectively to the crimp and containment by double sided adhesive tape; the other attachment means (heat sealing, glue, heat welding, ultrasonic welding) can also be used in the device of Figure 20.
  • the device is attachable to the skin of a patient using an adhesive layer (59) which is applied to the bottom (56) of the device.
  • the adhesive layer is protected by a release liner (54), which is a layer covering the adhesive layer (53). The user removes the release liner (54) just before attaching the device to the skin.
  • the release liner (54) is preferably connected to both free ends (8,8 ' ) of the first and second continuous flexible strips (18,49), thus by removing the release liber (54) also both strips are removed to establish the sterile connection between the outer surface (35) of the cartridge ' s septum and the fluid path enclosed in the containment (36).
  • the electronic circuitry of the infusion device is closed as well by removing the release liner (54) for example by removing an isolation paper between the terminal of a battery and the electronic circuitry.
  • the edges of the passage for the needle (62) are smooth, rounded and/or comprise a facetted face to reduce friction between the strips and the housing upon removal and/or prevent damage to the strips.
  • an infusion device (61) is presented where the protective cap (13) covering the first or second continuous flexible strip is used to remove the strips since the free ends (8,8 ' ) are connected to the cap.
  • the bottom of the housing comprises an aperture (62) for the needle that is intended for skin insertion.
  • the cap (13) may cover the passage (62) during shelflife.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un ensemble pour un dispositif d'injection ou de perfusion comprend i) une cartouche fermée par un septum et la surface du septum étant stérile et recouverte par une première bande souple continue, et ii) une unité de trajet de fluide comprenant un support de cartouche et un confinement de trajet de fluide comprenant une aiguille dans un intérieur, l'aiguille étant conçue pour pénétrer dans le septum de la cartouche à travers un passage dans le confinement de trajet de fluide. Le passage est fermé par une seconde bande souple continue maintenant l'intérieur du confinement de trajet de fluide dans une condition stérile. La cartouche est insérée dans le support de cartouche alignant le septum avec le passage et prenant en sandwich les deux bandes entre le septum et le confinement de trajet de fluide. Les deux bandes sont simultanément amovibles de la cartouche et du confinement de trajet de fluide, établissant ainsi une connexion stérile entre le septum et l'intérieur du confinement de trajet de fluide.
PCT/IB2019/051357 2018-03-15 2019-02-20 Ensemble pour dispositif d'injection ou de perfusion WO2019175688A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2020549705A JP2021515677A (ja) 2018-03-15 2019-02-20 注射または注入デバイスのためのアッセンブリ
CN201980019215.9A CN111902174B (zh) 2018-03-15 2019-02-20 用于注射或输注装置的组件
EP19710491.2A EP3765129A1 (fr) 2018-03-15 2019-02-20 Ensemble pour dispositif d'injection ou de perfusion
US17/017,182 US20210001048A1 (en) 2018-03-15 2020-09-10 Assembly for an injection or infustion device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18161873.7A EP3539596A1 (fr) 2018-03-15 2018-03-15 Ensemble pour un dispositif d'injection ou de perfusion
EP18161873.7 2018-03-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US17/017,182 Continuation US20210001048A1 (en) 2018-03-15 2020-09-10 Assembly for an injection or infustion device

Publications (1)

Publication Number Publication Date
WO2019175688A1 true WO2019175688A1 (fr) 2019-09-19

Family

ID=61683599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2019/051357 WO2019175688A1 (fr) 2018-03-15 2019-02-20 Ensemble pour dispositif d'injection ou de perfusion

Country Status (5)

Country Link
US (1) US20210001048A1 (fr)
EP (2) EP3539596A1 (fr)
JP (1) JP2021515677A (fr)
CN (1) CN111902174B (fr)
WO (1) WO2019175688A1 (fr)

Cited By (3)

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US11505776B2 (en) 2019-12-17 2022-11-22 Oribiotech Ltd Connector
US12076526B2 (en) 2018-03-27 2024-09-03 Ypsomed Ag Patch delivery device with skin contact sensor
US12083314B2 (en) 2018-03-15 2024-09-10 Ypsomed Ag Injection or infusion device comprising an improved release liner

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022104270A1 (fr) * 2020-11-16 2022-05-19 West Pharmaceutical Services, Inc. Système de raccordement pour un dispositif d'administration de médicament
WO2024038642A1 (fr) * 2022-08-18 2024-02-22 テルモ株式会社 Dispositif d'administration de solution médicale et procédé de fabrication de dispositif d'administration de solution médicale

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US3909910A (en) * 1973-03-29 1975-10-07 Union Carbide Corp Method of joining the ends of two conduits together in a sterile manner
US4019512A (en) 1975-12-04 1977-04-26 Tenczar Francis J Adhesively activated sterile connector
US6679529B2 (en) * 2001-08-06 2004-01-20 Theodore D. Johnson Connection system
US20080048436A1 (en) * 1997-05-09 2008-02-28 Pall Corporation Methods for making a connection and connector assemblies
US20160199568A1 (en) 2015-01-09 2016-07-14 BioQuiddity Inc. Sterile Assembled Liquid Medicament Dosage Control And Delivery Device
WO2017089271A1 (fr) * 2015-11-27 2017-06-01 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection de médicament
WO2017089286A1 (fr) * 2015-11-27 2017-06-01 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicament à capuchon

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DE10203598A1 (de) * 2002-01-30 2003-08-07 Disetronic Licensing Ag Injektionsgerät mit steril montierter Injektionsnadel sowie Nadelträger und Ampulle für solch ein Injektionsgerät
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CA2730684C (fr) * 2008-07-15 2016-11-29 Thomas Steffen Dispositif d'injection de ciment osseux
JP5832547B2 (ja) * 2010-11-03 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬剤を含有する針カニューレ
WO2014046950A1 (fr) * 2012-09-24 2014-03-27 Enable Injections, Llc Fiole pour médicament et assemblages d'injecteur et procédés d'utilisation
EP3060136A4 (fr) * 2013-10-18 2017-06-21 Lightside Md, Llc Dispositifs de support et leurs procédés de fabrication et d'utilisation
DK3193968T3 (da) * 2014-09-15 2019-01-02 Sanofi Sa Emballage til medicinsk anordning og medikament

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Publication number Priority date Publication date Assignee Title
US3909910A (en) * 1973-03-29 1975-10-07 Union Carbide Corp Method of joining the ends of two conduits together in a sterile manner
US4019512A (en) 1975-12-04 1977-04-26 Tenczar Francis J Adhesively activated sterile connector
US20080048436A1 (en) * 1997-05-09 2008-02-28 Pall Corporation Methods for making a connection and connector assemblies
US6679529B2 (en) * 2001-08-06 2004-01-20 Theodore D. Johnson Connection system
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US12083314B2 (en) 2018-03-15 2024-09-10 Ypsomed Ag Injection or infusion device comprising an improved release liner
US12076526B2 (en) 2018-03-27 2024-09-03 Ypsomed Ag Patch delivery device with skin contact sensor
US11505776B2 (en) 2019-12-17 2022-11-22 Oribiotech Ltd Connector

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JP2021515677A (ja) 2021-06-24
CN111902174B (zh) 2022-10-21
CN111902174A (zh) 2020-11-06
EP3765129A1 (fr) 2021-01-20
US20210001048A1 (en) 2021-01-07
EP3539596A1 (fr) 2019-09-18

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