WO2019153241A1 - Loci de polymorphisme mononucléotidique associés à des événements cardiovasculaires indésirables majeurs et application de ceux-ci - Google Patents

Loci de polymorphisme mononucléotidique associés à des événements cardiovasculaires indésirables majeurs et application de ceux-ci Download PDF

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Publication number
WO2019153241A1
WO2019153241A1 PCT/CN2018/075986 CN2018075986W WO2019153241A1 WO 2019153241 A1 WO2019153241 A1 WO 2019153241A1 CN 2018075986 W CN2018075986 W CN 2018075986W WO 2019153241 A1 WO2019153241 A1 WO 2019153241A1
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seq
gene
site
locus
allele
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PCT/CN2018/075986
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English (en)
Chinese (zh)
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刘小敏
徐怀前
刘晓
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深圳华大生命科学研究院
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Priority to CN201880088474.2A priority Critical patent/CN111670256B/zh
Priority to PCT/CN2018/075986 priority patent/WO2019153241A1/fr
Publication of WO2019153241A1 publication Critical patent/WO2019153241A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne 17 loci de polymorphisme mononucléotidique (SNP) associés à des événements cardiovasculaires indésirables majeurs (MACE) et une application de ceux-ci. Les 17 loci de SNP fournis par la présente invention sont obtenus sur la base de visites de suivi à grande échelle et d'analyse de données sur des patients souffrant d'une coronaropathie, et peuvent être utilisés en tant que marqueurs pour prédire l'apparition d'événements cardiovasculaires indésirables majeurs. De plus, la présente invention concerne en outre un kit pour prédire l'apparition de MACE chez un sujet, qui comprend des paires d'amorces et des paires de sondes utilisées pour amplifier et détecter les 17 loci de SNP décrits, étant capables de prédire le risque de MACE chez des sujets.
PCT/CN2018/075986 2018-02-09 2018-02-09 Loci de polymorphisme mononucléotidique associés à des événements cardiovasculaires indésirables majeurs et application de ceux-ci WO2019153241A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201880088474.2A CN111670256B (zh) 2018-02-09 2018-02-09 与主要不良心血管事件相关的单核苷酸多态性位点及其应用
PCT/CN2018/075986 WO2019153241A1 (fr) 2018-02-09 2018-02-09 Loci de polymorphisme mononucléotidique associés à des événements cardiovasculaires indésirables majeurs et application de ceux-ci

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PCT/CN2018/075986 WO2019153241A1 (fr) 2018-02-09 2018-02-09 Loci de polymorphisme mononucléotidique associés à des événements cardiovasculaires indésirables majeurs et application de ceux-ci

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WO2019153241A1 true WO2019153241A1 (fr) 2019-08-15

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107312851A (zh) * 2017-07-19 2017-11-03 北京泱深生物信息技术有限公司 心肌梗死生物标志物miR‑1283
CN107513576A (zh) * 2017-10-18 2017-12-26 北京生命科学研究所 一种用于检测遗传性心肌疾病的试剂盒及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1294934A2 (fr) * 2000-03-08 2003-03-26 Complexe Hospitalier de la Sagamie Polymorphismes de recepteurs de lipoproteines tres basse densite et utilisations associees
US20040018522A1 (en) * 2002-05-09 2004-01-29 Brigham And Women's Hospital, Inc. Identification of dysregulated genes in patients with multiple sclerosis
JP5479663B2 (ja) * 2002-12-20 2014-04-23 セレラ コーポレーション 心筋梗塞に関連する遺伝的多型、その検出方法および使用
CN101240320A (zh) * 2007-02-06 2008-08-13 上海主健生物工程有限公司 一种检测心血管疾病发病遗传风险的试剂盒
WO2009079762A1 (fr) * 2007-12-21 2009-07-02 Genesis Group Inc. Test permettant de diagnostiquer une myocardiopathie
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法
CN105002286B (zh) * 2015-07-30 2018-04-10 中国医学科学院阜外心血管病医院 与高血压和/或心血管疾病发病风险相关的多个单核苷酸多态性位点及相关应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107312851A (zh) * 2017-07-19 2017-11-03 北京泱深生物信息技术有限公司 心肌梗死生物标志物miR‑1283
CN107513576A (zh) * 2017-10-18 2017-12-26 北京生命科学研究所 一种用于检测遗传性心肌疾病的试剂盒及其应用

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CN111670256A (zh) 2020-09-15
CN111670256B (zh) 2023-10-27

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