WO2019151004A1 - Cosmetic material for sunscreen - Google Patents

Abstract

Provided is a cosmetic material for sunscreen that is less irritating to the eyes despite containing ethylhexyl methoxycinnamate and/or octocrylene, which are widely used as UV absorbers. The present invention relates to a cosmetic material for sunscreen that contains (A) at least one UV absorber selected from ethylhexyl methoxycinnamate and octocrylene and (B) a powder of which the area of a spot obtained three hours after spotting a suspension obtained by mixing with a 10-fold quantity (mass ratio) of the (A) UV absorber on a skin substitution membrane is 60% or less the area of a spot obtained three hours after spotting the (A) UV absorber alone, wherein the area of a spot obtained three hours after spotting the final product on a skin substitution membrane is 70% or less the area of a spot obtained three hours after spotting a composition different from the final product only by not containing the (B) powder on a skin substitution membrane.

Description

Sunscreen cosmetics

The present invention relates to a sunscreen cosmetic. More specifically, the present invention relates to a sunscreen cosmetic that hardly spreads on the skin after application and has little irritation to eyes.

Protecting the skin from the damage of ultraviolet rays is one of the important issues in skin care and body care, and various UV care cosmetics have been developed to minimize the adverse effects of ultraviolet rays on the skin. Sunscreen cosmetics (sunscreen cosmetics), a type of UV care cosmetics, absorb or scatter UVA and UVB on the skin by covering the skin with a coating film containing a UV absorber or UV scattering agent. It suppresses the amount of ultraviolet rays that reach it, and protects the skin from the harm of ultraviolet rays (Non-Patent Document 1).

Ethylhexyl methoxycinnamate and octocrylene are liquid UV absorbers having an absorption wavelength mainly in the UVB region, and are used in a large number of sunscreen cosmetics because of their excellent UV absorbing ability and availability. These liquid UV absorbers also serve as an oil solvent at the same time as UV absorbers. Therefore, it is possible to suppress the occurrence of stickiness by reducing the blending ratio of other oils, and the UV absorbers for the entire cosmetics. It is possible to achieve a high UV protection effect (high SPF) while maintaining a high blending ratio.

However, these UV absorbers are known to irritate the skin of sensitive skin users. In addition, when applied to the face regardless of sensitive skin, the UV absorber may move on the skin due to sebum, sweat, etc., and may invade the eyes from the corners of the eyes and cause pain in the eyes. It is a problem.

For example, Patent Document 1 proposes blending polypropylene glycol dimethyl ether to suppress percutaneous absorption of ethylhexyl methoxycinnamate for the purpose of alleviating irritation caused by such an ultraviolet absorber. However, even if the skin irritation can be suppressed, it does not suppress the spread of the UV absorber over time, and thus the irritation to the eyes cannot be alleviated.

In addition, Patent Document 2 proposes that a combination of a plurality of powder components having an ultraviolet scattering action is combined instead of mixing ethylhexyl methoxycinnamate and octocrylene. However, in order to obtain a high SPF, it is necessary to add a large amount of the powder component, and when applied to the skin, whitening may occur and the feeling of use may be significantly impaired.

JP 2003-206214 A Japanese Patent Laying-Open No. 2015-124172

The present invention has been made in view of the drawbacks of the prior art described above, and is a tan that is less irritating to the eye despite containing ethylhexyl methoxycinnamate and / or octocrylene, which are widely used as ultraviolet absorbers. The purpose is to provide stop cosmetics.

As a result of diligent research to solve the above problems, the present inventors have formulated a specific powder component together with ethylhexyl methoxycinnamate and / or octocrylene, so that it is difficult to spread on the skin after application and irritate the eyes. The present inventors have found that a sunscreen cosmetic that is difficult to carry out can be obtained, and have completed the present invention.

That is, the present invention
(A) at least one ultraviolet absorber selected from ethylhexyl methoxycinnamate and octocrylene;
(B) Spot area obtained 3 hours after spotting a suspension obtained by mixing 10 times amount (mass ratio) with (A) UV absorber on skin substitute membrane, (A) UV absorber Powder that is less than 60% of the area of the spot obtained 3 hours after spotting only,
Sunscreen cosmetics including
Spots obtained 3 hours after spotting the final product on the skin substitute membrane, the spot area obtained 3 hours after spotting a composition different from the final product on the skin substitute membrane only in that (B) it does not contain powder Sunscreen cosmetics that are 70% or less of the area of

The sunscreen cosmetic of the present invention can suppress the spread of the sunscreen cosmetic containing ethylhexyl methoxycinnamate and octocrylene on the skin by blending the powder component having the above specific properties. Therefore, especially when applied to the face, it is possible to suppress the ultraviolet absorber from entering the eye, there is little irritation to the eye, and the use feeling and safety are excellent.

The sunscreen cosmetic of the present invention essentially contains (A) an ultraviolet absorber and (B) a specific powder. This will be described in detail below.

<(A) UV absorber>
The (A) ultraviolet absorber in the present invention is selected from ethylhexyl methoxycinnamate and octocrylene, which are ultraviolet absorbers that are liquid at room temperature.
Ethyl hexyl methoxycinnamate (that is, octyl methoxycinnamate) is a light yellow liquid UV absorber having a maximum absorption wavelength at 308 nm and excellent UVB cutting ability. As a commercial item, "Pulsol MCX" (DSM Nutrition Japan Co., Ltd.) etc. can be used, for example.

Octocrylene (that is, 2-ethylhexyl 2-cyano-3,3-diphenyl acrylate) is a yellow liquid ultraviolet absorber capable of cutting a wide wavelength range of 290 to 350 nm while setting 310 nm as a maximum absorption wavelength. As a commercially available product, for example, “Ubinal N539T” (BASF Japan Ltd.), “Pulsol 340” (DSM Nutrition Japan Ltd.) or the like can be used.

The blending amount of the (A) ultraviolet absorber in the sunscreen cosmetic of the present invention is 3 to 30% by mass, preferably 5 to 20% by mass, more preferably 5 to 12% by mass with respect to the total sunscreen cosmetic. is there. (A) When the blending amount of the UV absorber is less than 3% by mass, the UV protection effect is not sufficiently exhibited, and when it exceeds 30% by mass, stickiness is caused and the feeling of use is impaired, or irritation to the skin and eyes Is not preferred because it tends to be too strong.

<(B) Powder>
The (B) powder in the present invention is a spot obtained after 3 hours after spotting the suspension on the skin substitute membrane when the suspension is mixed with the (A) ultraviolet absorber at a predetermined ratio to form a suspension. Is a powder that is 60% or less of the area of the spot obtained 3 hours after spotting only the ultraviolet absorber (A).
That is, the (B) powder is required to have a “suspension ratio of suspension” represented by the following formula of 60% or less.
Suspension spreading ratio (%) = ([suspension spot area] / [(A) spot area of ultraviolet absorber only]) × 100

Hereinafter, an evaluation method of “suspension rate of suspension” will be described.
First, the candidate powder is mixed with 10 times the mass ratio of the (A) ultraviolet absorber, that is, ethylhexyl methoxycinnamate, octocrylene, or a mixture thereof to obtain a suspension. Since these ultraviolet absorbers are liquid at room temperature, a uniform suspension can be obtained simply by adding powder and stirring.

The skin substitute membrane is a pseudo artificial skin substrate for measurement, which is made of a hydrophobic material close to human skin, and has a lattice-like unevenness (or groove) formed on the surface imitating the texture of human skin. is there.
Examples of the hydrophobic material close to human skin include resins such as polymethyl methacrylate (PMMA), polyethylene, and nylon. Among these, polymethyl methacrylate having excellent ultraviolet transmission characteristics is preferable because it is advantageous for measuring the area of a spot described later.

In order to reproduce the texture of human skin, it is preferable that irregularities are formed so that the arithmetic mean roughness Sa of the surface of the skin substitute membrane is 10 to 50 μm, more preferably 13 to 30 μm. The width of the recess is preferably 50 to 500 μm, more preferably 200 to 400 μm. The depth of the recess is preferably 30 to 150 μm, more preferably 50 to 100 μm. The unevenness can be formed by a conventionally known method such as sandblasting or molding.

Such a skin substitute membrane is disclosed in, for example, Japanese Patent No. 4871385. As a commercially available skin substitute membrane, “SPF MASTER (registered trademark) PA-01” (Shiseido Medical Rika Technology Co., Ltd.) (made of PMMA resin; arithmetic average roughness Sa = 17 μm) can be used. .

The method of spotting (applying) the suspension to the skin substitute membrane is not particularly limited as long as the application conditions between the samples can be made uniform. For example, using a micropipette or the like that can accurately measure the liquid volume. Preferably, 4-6 μl of the suspension droplet is gently placed on a horizontally placed skin substitute membrane. The spot diameter during spotting is preferably 5 to 6 mm.

After spotting the suspension, the skin substitute membrane is allowed to stand at room temperature and normal pressure (25 ° C., 1 atm) for 3 hours. During this time, the suspension spreads along the recesses on the surface of the skin substitute membrane, and the area of the spot increases.

Next, the area of the spot spread on the skin substitute membrane ([area of the suspension spot]) is measured. For the measurement of the area, it is preferable to use an ultraviolet irradiator and an ultraviolet camera taking advantage of the fact that the suspension contains an ultraviolet absorber. Specifically, the skin substitute membrane is irradiated with ultraviolet rays of black light and photographed with an ultraviolet camera. Since the suspension contains (A) an ultraviolet absorber, the spot portion absorbs ultraviolet rays and appears black on the ultraviolet camera. The area of the spot spread on the skin substitute film can be accurately measured by binarizing the image data with a computer.

On the other hand, the same (A) UV absorber as that used for the suspension was spotted on the skin substitute membrane under the same conditions as the suspension, and the spot area after 3 hours ([(A) UV Measure spot area of absorbent only]).
Finally, from these areas, the “suspension rate of the suspension” is calculated by the above formula.
The powder having a suspension spreading ratio of 60% or less, more preferably 40% or less, is determined as (B) powder that can be used in the present invention.

Specific examples of the powder (B) satisfying the spreading ratio of the suspension include (i) fumed hydrophobic silica, (ii) spherical porous silica, and (iii) spherical porous polymethyl methacrylate (PMMA). Can be mentioned. These powders have nothing in common in oil absorption capacity, specific surface area, etc., and cannot be properly specified at present unless they are based on the above-mentioned “suspension rate of suspension”. On the other hand, it has been confirmed that the “resin spreading ratio” of the silicone resin fine particles far exceeds 60% even when the average particle diameter and specific surface area are close to those of these powders.

(I) The fumed hydrophobized silica has an average particle size of 5 to 20 nm, a specific surface area of 50 to 200 m ² / g according to the BET method, and an oil absorption measured according to JIS K5101-13-2 of 30 to 35 ml / It is preferable to use 100 g of fine silica whose surface is hydrophobized with a treating agent such as dimethyldichlorosilane or dimethylpolysiloxane. Specifically, Aerosil R972 (Nippon Aerosil Co., Ltd.) etc. can be illustrated.

(Ii) The spherical porous silica preferably has an average particle size of 3 to 10 μm, a specific surface area of 250 to 350 m ² / g, and an oil absorption of 100 to 200 ml / 100 g. Specific examples include Sunsphere L-51 (AGC S-Tech Co., Ltd.).

(Iii) Spherical polymethylmethacrylate (PMMA) is a spherical polymer formed so as to have an average particle size of 5 to 10 μm, a specific surface area of 80 to 100 m ² / g, and an oil absorption of 100 to 200 ml / 100 g. (Meth) acrylate particles are preferred. Specifically, Techpolymer MBP-8 (Sekisui Plastics Co., Ltd.) can be preferably used.

The blending amount of the (B) powder in the sunscreen cosmetic of the present invention is 0.5 to 15% by mass, preferably 2 to 10% by mass, and most preferably about 5% by mass with respect to the total sunscreen cosmetic. . (B) When the blending amount of the powder is less than 0.5% by mass, it is difficult to sufficiently suppress irritation to the skin and eyes, and when it is more than 15% by mass, the feeling of use tends to be impaired.

In addition to the essential components (A) UV absorber and (B) powder described above, the sunscreen cosmetic of the present invention has other optional components that can be usually blended in the sunscreen cosmetic with the effects of the present invention. You may include in the range which does not inhibit.

<Ultraviolet absorber other than (A) above>
The sunscreen cosmetic of the present invention may contain an ultraviolet absorber other than (A). By blending an ultraviolet absorber other than ethylhexyl methoxycinnamate and octocrylene, the UV protection ability in the UVA and / or UVB region can be further improved. Even in this case, it is preferable that the total blending amount of the ultraviolet absorbers other than (A) and (A) is within the blending amount range described above for (A).
Such an ultraviolet absorber is not particularly limited. For example, t-butylmethoxydibenzoylmethane, ethylhexyltriazone, bisethylhexyloxyphenol methoxyphenyltriazine, diethylaminohydroxybenzoyl hexyl benzoate, oxybenzone-3 And methylenebisbenzotriazolyltetramethylbutylphenol, polysilicone-15, phenylbenzimidazolesulfonic acid, homosalate, ethylhexyl salicylate, and the like.

<Ultraviolet scattering agent>
The sunscreen cosmetic of the present invention may contain a powder (ultraviolet scattering agent) that physically shields ultraviolet rays by reflection / scattering.
The ultraviolet scattering agent that can be blended in the present invention is not particularly limited as long as it is a powder used as an ultraviolet scattering agent in the cosmetics field. Specific examples include one selected from titanium oxide, zinc oxide, barium sulfate, iron oxide, talc, mica, sericite, kaolin, titanium mica, bitumen, chromium oxide, chromium hydroxide, silica, cerium oxide, and the like. Two or more types can be mentioned. In particular, it is preferable from the viewpoint of optical properties to use a powder having a refractive index of 1.5 or more, such as zinc oxide or titanium oxide.

Further, the particle surface of the UV scattering agent may be hydrophobized. Dispersibility in oil and water resistance are improved by subjecting the surface to hydrophobic treatment. Surface treatment methods include silicone treatment such as methylhydrogenpolysiloxane and methylpolysiloxane; alkylsilane treatment; fluorine treatment with perfluoroalkyl phosphate ester, perfluoroalcohol, etc .; amino acid treatment with N-acyl glutamic acid, etc. And lecithin treatment; metal soap treatment; fatty acid treatment; alkyl phosphate ester treatment and the like.

In the present invention, (A) ethylhexyl methoxycinnamate and octocrylene, which are ultraviolet absorbers, tend to spread on the skin when the amount of the ultraviolet scattering agent is small. On the other hand, if an ultraviolet scattering agent is added too much, whiteness at the time of application may be noticeable or a powdery feeling may be produced.
In the present invention, the spread of sunscreen cosmetics on the skin can be reduced by blending the powder (B). Therefore, even in the situation where the blending amount of the UV scattering agent is small or not blended at all, The spread of the absorbent can be reduced. Specifically, when taking the oil-in-water emulsified form, a particularly excellent eye irritation reduction effect is achieved in a formulation in which the total amount of UV scattering agent is 3% by mass or less based on the total amount of sunscreen cosmetics. it can. On the other hand, when taking the water-in-oil type emulsified form, a particularly excellent ocular irritation reduction effect can be achieved in a formulation in which the total amount of ultraviolet scattering agent is 10% by mass or less.

<TRPV1 activity inhibitor>
The present inventors have found that the irritation to the eye can be further suppressed by adding a TRPV1 activity inhibitor to the sunscreen cosmetic of the present invention. TRPV1 belongs to the TRP (transient receptor potential) ion channel superfamily and is known as a capsaicin receptor. The present inventors have revealed that the cause of irritation when ethylhexyl methoxycinnamate and octocrylene entered the eye is due to the activation of TRPV1, and that the eye irritation is further suppressed by suppressing the activation of TRPV1. Newly found.
When TRPV1 is activated, calcium ions are taken into the cells. Therefore, TRPV1 activity inhibitors use, for example, HEK293 cells in which TRPV1 is forcibly expressed, and have an inhibitory effect on the reaction caused by a positive control substance (capsaicin, etc.). Screening can be done by imaging.
As a result of the above screening, it was confirmed that Yuzu seed oil, resveratrol, orange oil, PEG-9 polydimethylsiloxyethyl dimethicone, ethylene glycol distearate, stearic acid, and zinc myristate had a TRPV1 activity inhibitory effect. Among these, yuzu seed oil and resveratrol are particularly preferable from the viewpoint of the effect of suppressing eye irritation. Most preferred is yuzu seed oil.

When a TRPV1 activity inhibitor is added to the sunscreen cosmetic of the present invention, it is 0.5 to 5% by mass, more preferably 0.5 to 3% by mass, and most preferably about 1% by mass with respect to the total sunscreen cosmetic. %. When the blending amount of the TRPV1 activity inhibitor is less than 0.5% by mass, the effect of the TRPV1 activity inhibitor can hardly be realized, and when the blending amount is more than 5% by mass, the feeling of use tends to be impaired.

Examples of other optional components include alcohols, water-soluble polymers, oil-soluble polymers, surfactants, powder components other than the above (B) powder and ultraviolet scattering agent, various oils, and the like. It is not limited.

Examples of alcohols include lower alcohols such as ethanol and isopropanol, and polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, and polybutylene glycol.

Examples of the water-soluble polymer include homopolymers or copolymers of 2-acrylamido-2-methylpropanesulfonic acid (hereinafter abbreviated as “AMPS”). The copolymer is a copolymer composed of a comonomer such as vinyl pyrrolidone, acrylic acid amide, sodium acrylate, hydroxyethyl acrylate and the like. That is, an AMPS homopolymer, a vinylpyrrolidone / AMPS copolymer, a dimethylacrylamide / AMPS copolymer, an acrylic amide / AMPS copolymer, a sodium acrylate / AMPS copolymer, and the like are exemplified. Furthermore, carboxyvinyl polymer, ammonium polyacrylate, sodium polyacrylate, sodium acrylate / alkyl acrylate / sodium methacrylate / alkyl methacrylate copolymer, carrageenan, pectin, mannan, curdlan, chondroitin sulfate, starch, Glycogen, gum arabic, sodium hyaluronate, tragacanth gum, xanthan gum, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, guar gum, dextran, kerato sulfate, locust bean gum, succinoglucan, chitin, chitosan, carboxymethyl chitin, agar etc. Illustrated.

Examples of the oil-soluble polymer include trimethylsiloxysilicic acid, alkyl-modified silicone, polyamide-modified silicone, dimethicone crosspolymer, (dimethicone / vinyl dimethicone) crosspolymer, polymethylsilsesquioxane, and the like.

Examples of the surfactant include anionic, cationic, nonionic, and amphoteric surfactants, and include silicone-based or hydrocarbon-based surfactants.

Examples of powder components other than the above (B) powder and ultraviolet scattering agent include nylon and acrylic polymer spherical powder, silica powder, silicone powder, metal oxide powder surface-treated with a metal-free surface treatment agent, and the like. Is done.

<Sunscreen cosmetics>
The sunscreen cosmetic of the present invention spotts a composition that differs from the final product only in that the spot area after 3 hours after spotting the final product on the skin substitute film does not contain powder. Thus, it is 70% or less of the area of the spot after 3 hours.
In other words, the sunscreen cosmetic of the present invention is required to have a “extended product spreading ratio” represented by the following formula of 70% or less.
Spread ratio of final product (%) = ([area of spot of final product] / [area of spot of composition excluding (B) powder from final product]) × 100

Hereinafter, an evaluation method of “the spread ratio of the final product” will be described.
The final product to be evaluated is spotted on the skin substitute membrane in the same manner as the evaluation of the “suspension spread ratio”. After leaving the skin substitute membrane as it is at room temperature and normal pressure (25 ° C., 1 atm) for 3 hours, the area of the spot ([spot area of the final product]) spreading on the skin substitute membrane is measured. Since the final product contains an ultraviolet absorber, an ultraviolet irradiator and an ultraviolet camera can also be used here for measuring the area.

On the other hand, a composition different from the final product was prepared only in that it did not contain (B) powder, and the spot area after 3 hours ([B) Spot area]).
From these areas, the “extension rate of the final product” is calculated by the above formula.
A product having a final product spreading rate of 70% or less, more preferably 50% or less, is determined as the sunscreen cosmetic of the present invention. If the spread rate of the final product is 70% or less, the cosmetic is less likely to spread on the skin and less likely to enter the eye.

The sunscreen cosmetic of the present invention can be provided in the form of an oil-in-water emulsified cosmetic, a water-in-oil emulsified cosmetic, or an oily cosmetic. As a specific dosage form, there are dosage forms such as sunscreen milky lotion and sunscreen cream, which can be produced using a conventional method suitable for each dosage form.

When the (A) ultraviolet absorber and the (B) powder coexist in the same phase, they tend to exhibit a particularly high eye irritation reducing effect. Here, “coexistence in the same phase” means that (A) the ultraviolet absorber and (B) powder are not required to be completely present in the same phase, but substantially coexist. Refers to the state of Specifically, 90% or more, more preferably 95% or more, and still more preferably 98% or more of each of the (A) ultraviolet absorber and (B) powder may coexist in the same phase. Since ethylhexyl methoxycinnamate and octocrylene are oil-soluble, both (A) the ultraviolet absorber and (B) the powder coexist in the same oil phase, that is, the sunscreen cosmetic is an oil-in-water emulsified cosmetic. (A) UV absorber and (B) powder are both present in the internal phase (oil phase), while in the form of a water-in-oil emulsified cosmetic, It is preferable that both A) the ultraviolet absorber and (B) powder are present in the outer phase (oil phase).
In particular, in the case of oil-in-water emulsified cosmetics, from the viewpoint of usability, those which do not use ultraviolet scattering agents such as fine particle titanium oxide and fine particle zinc oxide tend to be preferred. In such a case, ethylhexyl methoxycinnamate And octocrylene tends to irritate eyes. The sunscreen cosmetic of the present invention that can suppress the spread on the skin without relying on an ultraviolet scattering agent is a form of an oil-in-water emulsified cosmetic that can realize both good spreading and a refreshing feeling of use. Highly effective in.
Therefore, the sunscreen cosmetic of the present invention is in the form of an oil-in-water emulsified cosmetic and has a formulation in which both (A) the ultraviolet absorber and (B) powder are present in the internal phase (oil phase). In particular, it can exhibit a particularly high effect and can significantly reduce irritation to the eyes.

Further, the viscosity of the sunscreen cosmetic of the present invention is not particularly limited. However, when the viscosity is 10,000 mPa · s or more, the problem due to extension is hardly caused in the first place. Therefore, the present invention is particularly effective in a system having a viscosity of 10,000 mPa · s or less.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto. Unless otherwise specified, the blending amount is expressed in mass% with respect to the system in which the component is blended.

<Evaluation of spreading ratio of suspension>
1 g of the powder described in Table 1 was mixed with 10 g of octocrylene (trade name “Ubinal N539T”; BASF Japan Ltd.) to obtain suspensions. 5 μl of this suspension was gently spotted using a micropipette on a skin substitute membrane (trade name “SPF MASTER (registered trademark) PA-01”; Shiseido Medical Rika Technology Co., Ltd.). After leaving the skin substitute membrane at room temperature and normal pressure (25 ° C, 1 atm) for 3 hours, it is photographed using an ultraviolet irradiator and an ultraviolet camera, and the image data is binarized by a computer to replace the skin. The area of the suspension spot spread on the membrane was measured. Each suspension was spotted at 10 locations, and the average of the spot areas was used to calculate the spreading ratio of the suspension.
On the other hand, only octocrylene was spotted on the skin substitute membrane under the same conditions, and the area of the spot after 3 hours was measured. Again, spotting was performed 10 times, and the average of the areas of those spots was used to calculate the spreading rate.
From the area of each suspension and the spot of octocrylene, the spreading ratio of each suspension was calculated. The results are shown in Table 1.

In addition, the spreading ratio of the suspension was calculated in the same manner using ethylhexyl methoxycinnamate (trade name “Pulsol MCX”; DSM Nutrition Japan Co., Ltd.) instead of octocrylene. The results are shown in Table 2.

As is clear from the results shown in Tables 1 and 2, when blended with fumed hydrophobic silica, spherical porous silica, and spherical porous polymethyl methacrylate, octocrylene or It was confirmed that the spread of ethylhexyl methoxycinnamate on the skin substitute membrane (suspension rate of suspension) can be reduced to 60% or less. Especially, it was confirmed that the fumed hydrophobized silica can reduce the spreading ratio of the suspension to about 10% and has an extremely high effect. On the other hand, when the silicone resin fine particles were blended, the spread of the spot could hardly be suppressed for either octocrylene or ethylhexyl methoxycinnamate.

<Evaluation of final product spread rate>
(1) Oil-in-water emulsified sunscreen cosmetics In the formulation shown in Table 3, oil-in-water emulsified sunscreen cosmetics were produced by conventional methods.
Specifically, (1) to (9) and (23) were added to (24) and mixed uniformly, and then the powder of (21) was uniformly dispersed to obtain an aqueous phase. On the other hand, after (10) to (20) were uniformly mixed, (22) was added and uniformly dispersed to obtain an oil phase. Thereafter, the oil phase was gradually added to the aqueous phase, and after uniform dispersion with a homomixer, the emulsified particles were prepared to obtain the sunscreen cosmetic of Example 1.
In Comparative Example 1, a sunscreen cosmetic was obtained without adding (20) and (22).

5 μl of the sunscreen cosmetic of Example 1 was gently spotted using a micropipette on a skin substitute membrane (trade name “SPF MASTER (registered trademark) PA-01”; Shiseido Medical Rika Technology Co., Ltd.). After leaving the skin substitute membrane at room temperature and normal pressure (25 ° C, 1 atm) for 3 hours, it is photographed using an ultraviolet irradiator and an ultraviolet camera, and the image data is binarized by a computer to replace the skin. The area of the spot spread on the film was measured. Spotting was performed at three locations, and the average of them was used to calculate the spreading ratio of the final product.
On the other hand, for Comparative Example 1, spotting was performed on the skin substitute membrane under the same conditions, and the area of the spot after 3 hours was measured.
From the spot area obtained for Example 1 and the spot area obtained for Comparative Example 1, the spread ratio of the final product was calculated. The results are shown in Table 3.

As is apparent from the results shown in Table 3, in Example 1 in which fumed hydrophobic silica was blended, the spread of the cosmetic material on the skin substitute film was compared with that in Comparative Example 1 in which this powder was not blended (final product). It was confirmed that the spread ratio of the film could be reduced to 41.9%.

<Evaluation of eye irritation of sunscreen cosmetics>
Twelve specialist panels applied the sunscreen cosmetics of Example 1 or Comparative Example 1 to the left and right sides of the face (including around the eyes), respectively, and evaluated the presence or absence of irritation to the eyes after 3 hours. .
There were 11 out of 12 specialized panels that felt irritation in the eye applied with Comparative Example 1, whereas only 5 specialized panels felt irritation in the eye applied with Example 1. Met.

(2) Water-in-oil emulsified sunscreen cosmetics In addition, water-in-oil emulsified sunscreen cosmetics were prepared according to the formulation shown in Table 4 by a conventional method.
Specifically, after the components constituting the oil phase were uniformly mixed, methyl methacrylate crosspolymer was added and uniformly dispersed to obtain an oil phase. On the other hand, the components constituting the aqueous phase were uniformly mixed and dissolved to obtain an aqueous phase. The oil phase was gradually added to the aqueous phase, and after uniform dispersion with a homomixer, the emulsified particles were prepared to obtain sunscreen cosmetics of Examples 2-4.
In Comparative Examples 2 and 3, sunscreen cosmetics were obtained without adding methyl methacrylate crosspolymer.
The spread ratio of the final product was calculated in the same manner as in Example 1. The results are shown in Table 4.

As is apparent from the results shown in Table 4, in Examples 2 to 4 in which methyl methacrylate crosspolymer was blended, compared with Comparative Examples 2 and 3 in which this powder was not blended, the cosmetics on the skin substitute film It was confirmed that the spread (the spread ratio of the final product) can be reduced to 60% or less.

Claims (7)

1. (A) at least one ultraviolet absorber selected from ethylhexyl methoxycinnamate and octocrylene;
   (B) Spot area obtained 3 hours after spotting a suspension obtained by mixing 10 times amount (mass ratio) with (A) UV absorber on skin substitute membrane, (A) UV absorber Powder that is less than 60% of the area of the spot obtained 3 hours after spotting only,
   Sunscreen cosmetics including
   Spots obtained 3 hours after spotting the final product on the skin substitute membrane, the spot area obtained 3 hours after spotting a composition different from the final product on the skin substitute membrane only in that (B) it does not contain powder Sunscreen cosmetics that are 70% or less of the area of the skin.
2. The sunscreen cosmetic according to claim 1, wherein (A) the ultraviolet absorber and (B) the powder coexist in the same phase.
3. The sunscreen cosmetic according to claim 2, which is in the form of an oil-in-water emulsified cosmetic, wherein (A) the ultraviolet absorber and (B) powder are both present in the internal phase (oil phase).
4. The sunscreen cosmetic according to claim 3, further comprising an ultraviolet scattering agent, the total amount of which is 3% by mass or less based on the total amount of the sunscreen cosmetic.
5. The sunscreen cosmetic according to claim 2, which is in the form of a water-in-oil emulsified cosmetic, wherein (A) the ultraviolet absorber and (B) powder are both present in the outer phase (oil phase).
6. The sunscreen cosmetic according to claim 5, further comprising an ultraviolet scattering agent, the total amount of which is 10% by mass or less based on the total amount of the sunscreen cosmetic.
7. The sunscreen cosmetic according to any one of claims 1 to 6, further comprising a TRPV1 activity inhibitor.