WO2019140927A1 - 超声换能器、聚焦超声治疗设备 - Google Patents
超声换能器、聚焦超声治疗设备 Download PDFInfo
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Definitions
- the invention belongs to the field of high-intensity focused ultrasound technology, and in particular relates to an ultrasonic transducer and a focused ultrasound therapy device.
- High Intensity Focused Ultrasound (HIFU) technology has been widely used in medical, scientific research, material processing and other fields. It utilizes the focus and penetration of ultrasound to focus ultrasound at a specific location and utilizes focus. High energy at the domain treats disease, stimulates response, changes material properties, and more.
- high-intensity focused ultrasound technology has been used clinically to treat benign and malignant tumors such as liver cancer, breast cancer, kidney cancer, bone tumor, and uterine fibroids.
- the principle is to focus ultrasound on the lesions in the human body to make the focal region
- the high energy density mechanical energy is converted into thermal energy, causing coagulative necrosis (also known as ultrasonic thermal ablation) of the diseased tissue; at the same time, due to the low ultrasonic energy density on the acoustic channel, the normal tissue around the diseased tissue and the acoustic channel is ensured.
- the impact or impact is acceptable.
- Ultrasound transducers are a core component of high-intensity focused ultrasound technology that converts electrical energy into mechanical energy and emits ultrasound from the sounding surface in a normal direction to focus the emitted ultrasound.
- the sounding surface of the existing focused ultrasound transducer is mostly a spherical surface, and the ultrasonic waves emitted by it are traveling waves and are focused near the spherical center of the spherical cap. Due to the characteristics of ultrasound, the focal field of the existing ultrasonic transducer is actually similar to a cigar shape or a spindle shape, and its length in the direction of the sound axis is relatively large, generally exceeding 10 mm, while the dimensions of the other two short axes are 2 mm. 3mm (for example, when the ultrasonic frequency is 1MHz).
- the existing ultrasonic transducer has a large focal range, insufficient energy concentration, low energy density in the focal region, and the sound pressure can only reach the level of 10 7 Pa at most, thereby causing it to not rapidly ablate the diseased tissue, and the treatment time is long. The treatment effect is not good.
- the invention at least partially solves the problem that the existing ultrasonic transducer has a large focal length and a shape of "cigar shape", and provides an ultrasonic transducer and a focused ultrasonic therapy device capable of forming a small-sized spherical focal region.
- the technical solution adopted to solve the technical problem of the present invention is an ultrasonic transducer including a sounding unit and a sound emitting surface, and the sounding unit is configured to generate ultrasonic waves, and
- the sound emitting surface is a spherical surface having a first notch, a second notch, and a third notch, wherein a spherical surface of the spherical surface corresponding to the sounding surface is a main spherical surface, the first notch and the first The two notches are respectively located at a intersection of a diameter perpendicular to the main spherical surface and the spherical surface, and the third notch connects the first notch and the second notch;
- the sound emitting surface has a circular arc shape in a cross section parallel to the main spherical surface, and the circular arc shaped opening corresponds to the third a notch, the circular arc corresponding to a central angle greater than 180 degrees and less than 360 degrees;
- the sound emitting surface has the ability to reflect ultrasound, and the ultrasonic waves generated by the sounding unit are focused on a spherical center corresponding to the sound emitting surface.
- the edges of the first notch and the second notch are respectively located in the first plane and the second plane.
- first plane and the second plane are both parallel to the main spherical surface.
- the distance between the first plane and the second plane is between 80 mm and 1000 mm.
- the distance between the first plane and the second plane is between 150 mm and 500 mm.
- the distance between the first plane and the main spherical surface is equal to the distance between the second plane and the main spherical surface.
- the sound emitting surface has a circular arc shape in any cross section parallel to the main spherical surface, and the circular arc corresponding to a central angle is greater than 180 degrees and less than 360 degrees.
- the sound-emitting surface has the same circular arc-shaped opening in a section parallel to the main spherical surface.
- the sounding surface is equal in a central angle corresponding to a circular arc shape in a section parallel to the main spherical surface.
- a circular arc corresponding to a circular arc in a cross section parallel to the main spherical surface is greater than 180 degrees and smaller than a central angle 300 degrees.
- a circular arc corresponding to a circular arc in a cross section parallel to the main spherical surface is greater than 200 degrees and Less than 280 degrees.
- the distance from the two sides of the main spherical surface is a range of 40 mm to 500 mm from both sides of the main spherical surface.
- the spherical surface corresponding to the sound emitting surface has a diameter of 100 mm to 3000 mm.
- the spherical surface corresponding to the sound emitting surface has a diameter of 200 mm to 2000 mm.
- the sound emitting surface is symmetrically disposed with respect to the main spherical surface.
- the technical solution adopted to solve the technical problem of the present invention is a focused ultrasound therapy device, which comprises:
- the sound emitting surface has the ability to reflect ultrasonic waves, and the corresponding central angle exceeds 180 degrees, so the ultrasonic waves emitted from the position of the sound emitting surface are reflected back by the opposite sound emitting surface, thereby making the area in the area
- the ultrasound forms a standing wave, and the ultrasound emitted by other parts of the sounding surface is not reflected, and is still a traveling wave.
- the focal region of the ultrasonic wave can be compressed in a partial direction to change from a cigar shape to a regular shape close to a spherical shape, and the size becomes small, thereby making the focal region Increased energy density, improve treatment effect and efficiency, reduce damage to normal tissues; at the same time, it can also reduce scattering, reflection, etc. of ultrasound in the uneven tissue of the human body, reduce the offset and distortion of the focal region, and facilitate the coke The domain is accurately located.
- the sounding surface also has three notches, so the human body, materials to be treated, research equipment, etc. can enter the sounding surface through these gaps and reach the vicinity of the focal region, which is convenient for the practical application of the ultrasonic transducer.
- the ultrasonic transducer of the present invention is preferably used in a focused ultrasound treatment device, and of course, in other fields such as scientific research, material processing, and the like.
- FIG. 1 is a schematic structural view of an ultrasonic transducer according to an embodiment of the present invention
- FIG. 2 is a schematic structural view of a sound emitting surface in an ultrasonic transducer according to an embodiment of the present invention
- FIG. 3 is a schematic structural view of a sound emitting surface in a direction parallel to a main spherical surface of an ultrasonic transducer according to an embodiment of the present invention
- FIG. 4 is a schematic structural view of a sound emitting surface in a direction perpendicular to a main spherical surface in an ultrasonic transducer according to an embodiment of the present invention
- FIG. 5 is a schematic structural view of a sound emitting surface in a cross section parallel to a main spherical surface in an ultrasonic transducer according to an embodiment of the present invention
- FIG. 6 is a spatial distribution diagram of simulated sound field intensity corresponding to a sounding surface of a 60 degree central angle
- FIG. 7 is a spatial distribution diagram of simulated sound field intensity corresponding to a sounding surface of a 100 degree central angle
- FIG. 8 is a spatial distribution diagram of simulated sound field intensity of a sounding surface corresponding to a central angle of 220 degrees;
- FIG. 9 is a spatial distribution diagram of simulated sound field intensity of a sounding surface corresponding to a central angle of 300 degrees;
- Figure 10 is a simulated sound field intensity distribution diagram of the sounding surface of different central angles on the X-axis
- Figure 11 is a simulated sound field intensity distribution diagram of the sounding surface of different central angles on the Y-axis
- Figure 12 is a simulated sound field intensity distribution diagram of the sounding surface of different central angles on the Z axis
- Figure 13 is a -6 dB width diagram of the simulated sound field of the sounding surface of different central angles on each axis;
- Figure 14 is a focal volume diagram of a -6 dB width corresponding to the sounding surface of different central angles
- Figure 15 is a diagram showing the simulated sound field intensity distribution on the X-axis of the sound-emitting surface having different sizes along the Y-axis;
- Figure 16 is a diagram showing the simulated sound field intensity distribution on the Y-axis of the sound-emitting surface having different sizes along the Y-axis;
- Figure 17 is a graph showing the simulated sound field intensity distribution on the Z-axis of the sound-emitting surface having different sizes along the Y-axis;
- Figure 18 is a -6 dB width diagram of the simulated sound field on each axis along the Y-axis size
- 19 is a focal volume volume diagram of a -6 dB width corresponding to an analog sound field of a sounding surface having different sizes along the Y axis;
- the reference numerals are: 1, the outer casing; 2, the upper cover; 3, the sound emitting surface; 31, the first notch; 32, the second notch; 33, the third notch; 4, the piezoelectric array element; 91, the first plane; 92, the second plane; 99, the main spherical surface.
- the present embodiment provides an ultrasonic transducer including a sounding unit and a sounding surface 3 for generating ultrasonic waves.
- the sound emitting surface 3 is a spherical surface having a first notch 31, a second notch 32, and a third notch 33, wherein a spherical surface of the spherical surface corresponding to the sounding surface 3 is a main spherical surface 99, a first notch 31 and a
- the two notches 32 are respectively located at two intersections of the diameter perpendicular to the main spherical surface 99 and the spherical surface, and the third notch 33 connects the first notch 31 and the second notch 32.
- the sound emitting surface 3 has a circular arc shape in a section parallel to the main spherical surface 99, and the circular arc shaped opening corresponds to the third notch 33, and the circular arc corresponds to The central angle is greater than 180 degrees and less than 360 degrees.
- the sounding surface 3 has the ability to reflect ultrasound, and the ultrasonic waves generated by the sounding unit are focused on the center of the sphere corresponding to the sounding surface 3.
- the ultrasonic transducer of the embodiment has a sounding unit, and the sounding unit is a device that can generate ultrasonic waves, and the material of the sounding unit may include a piezoelectric ceramic or a 1-3 type piezoelectric composite material or the like.
- the sounding unit can be made to emit ultrasonic waves from the respective positions of the sounding surface 3, and the ultrasonic waves emitted at each position are propagated along the sounding surface 3 in the normal direction of the position. These ultrasounds can eventually be focused at the desired location (including direct focus or post-reflection focus).
- the sound emitting surface 3 may be a sound transmitting surface having a predetermined shape, and the sounding unit (such as the piezoelectric array element 4) may be disposed behind the sound emitting surface 3; or, the sound emitting surface 3 may be directly The emitting surface of the sounding unit itself.
- the sounding unit such as the piezoelectric array element 4
- the sounding unit can also take different forms.
- the sounding unit may be a plurality of piezoelectric array elements 4 (such as rectangular piezoelectric ceramic sheets) disposed at different positions of the sounding surface 3, that is, a plurality of piezoelectric array elements 4 are "spliced" to the starting sound surface 3; or, sounding
- the unit may also have the same shape as the sounding surface 3 (for example, a piezoelectric ceramic sheet in which the sounding unit is shaped).
- the driving circuit of the sounding unit in addition to the sound emitting surface 3 and the sounding unit, the driving circuit of the sounding unit, the closed driving circuit and the housing of the sounding unit may be included (for example, the housing of the sounding unit may include the outer casing 1).
- the housing of the sounding unit may include the outer casing 1).
- Other components such as the upper cover 2, the lower cover, the end cover 5, etc., are not described in detail herein.
- the sound emitting surface 3 of the ultrasonic transducer of the present embodiment corresponds to a spherical surface lacking three portions.
- the two portions (the first notch 31 and the second notch 32) which are missing from the above-mentioned sounding surface 3 are portions of the spherical surface at both ends of a diameter, wherein the spherical core perpendicular to the diameter
- the face that is, the face that passes through the center of the ball
- the third portion (third notch 33) missing from the sounding surface 3 is a portion that connects the first notch 31 and the second notch 32 from the side.
- the top of the spherical surface may be first placed in the vertical direction. Cut off a part of each of the bottom ends, and then cut off a part of the side, and the cut side of the side should connect the top and bottom cuts, and the remaining spherical surface is the above sounding surface 3.
- the sounding surface 3 is in a section parallel to the main spherical surface 99
- the cut-out shape is a circular arc shape, and the circular core corresponding to the central angle is greater than 180 degrees and less than 360 degrees, and the opening corresponds to the above third notch 33. That is, at least in the portion close to the main spherical surface 99, the above third notch 33 cuts only the portion of the sphere "less than half a ball", while the remaining sounding surface 3 is "more than half. The part of the ball.
- the above sound emitting surface 3 has the ability to reflect ultrasonic waves, so as shown in FIG. 5, the ultrasonic waves emitted from the circular arc portion whose central angle exceeds 180 degrees are reflected back by the opposite sound emitting surface 3, and the circle exceeding 180 degrees
- the arc portion can also reflect the ultrasonic waves emitted from the opposite sounding surface 3, so that the ultrasonic waves can be returned in a part of the region (the portion marked with a diagonal line in Fig. 5) to form a standing wave, changing the focusing condition of the ultrasonic wave and the shape of the focal region;
- the ultrasound emitted by the portion corresponding to the arc and the opening is not reflected, so the ultrasound emitted by the arc is still a traveling wave.
- the ultrasonic wave generated by the ultrasonic transducer of the present embodiment is actually a combination of a traveling wave and a standing wave, whereby its propagation, focusing, and the like are changed.
- the ultrasonic transducer can compress the long axis of the original cigar-shaped focal region, thereby making the focal region closer to a spherical shape and smaller in size, thereby increasing the energy density at the focal region, improving the therapeutic effect and efficiency, and reducing Small damage to normal tissue.
- the ultrasonic transducer can also reduce the scattering, reflection, etc. of the ultrasonic in the uneven tissue in the human body, reduce the offset and distortion of the focal region, and facilitate the accurate positioning of the focal region.
- the sounding surface 3 also has three notches, so that the human body, the material to be treated, the research equipment, and the like can enter the sounding surface 3 through these gaps and reach the vicinity of the focal region, facilitating the practical application of the ultrasonic transducer.
- the edges of the first notch 31 and the second notch 32 are located in the first plane 91 and the second plane 92, respectively. More preferably, the first plane 91 and the second plane 92 are both parallel to the main spherical surface 99.
- the above first notch 31 and second notch 32 are preferably spherical caps that are truncated by a plane, more preferably spherical caps that are intercepted by two parallel planes, that is, two truncated spherical caps.
- the bottom surfaces are preferably parallel to each other.
- the spherical surface obtained by removing the first notch 31 and the second notch 32 corresponds to a structure obtained by abutting the bottom surfaces of the two table tops.
- the bottom surfaces of the two tables are both the main spherical surface 99, and the heights of the two can be different.
- the shape of the sounding surface 3 of the above form is close to the table, relatively regular, and simple in structure.
- first notch 31 and second notch 32 are cut by planes that are not parallel to each other, or are cut by a non-planar surface.
- the distance between the first plane 91 and the second plane 92 is from 80 mm to 1000 mm, and more preferably from 150 mm to 500 mm.
- the distance between the first notch 31 and the second notch 32 is preferably in the above range (of course, the spherical surface corresponding to the sounding surface 3 should be larger than the above distance), Such a sounding surface 3 is sufficient in area to produce ultrasound suitable for practical use.
- the distance between the first plane 91 and the main spherical surface 99 is equal to the distance between the second plane 92 and the main spherical surface 99.
- first notch 31 and the second notch 32 are preferably cut by two planes equal to the distance from the center of the ball, so they are equal in size and symmetrically distributed.
- the distance between the first notch 31 and the second notch 32 is different from the center of the sphere, or the shape is fundamentally different.
- the sound emitting surface 3 has a circular arc shape in any cross section parallel to the main spherical surface 99, and the circular arc corresponding to the central angle is greater than 180 degrees and less than 360 degrees.
- the sound emitting surface 3 has a circular arc shape in a cross section parallel to the main spherical surface 99, but as a more preferred manner, the sound generating surface 3 is arbitrarily parallel to the main spherical surface 99.
- the arc shape corresponding to the central angle of more than 180 degrees and less than 360 degrees can be obtained, thereby ensuring that the sounding surface 3 can generate standing waves at various positions in the vertical direction.
- the partial position of the sounding surface 3 is not circular (e.g., a separate two-arc arc) in a section parallel to the main spherical surface 99.
- the sound-emitting surface 3 has the same circular arc-shaped opening direction in any section parallel to the main spherical surface 99; further preferably, the sound-emitting surface 3 has an arc in any section parallel to the main spherical surface 99 The center angles corresponding to the shapes are equal.
- the above third notches 33 are preferably oriented in the same direction, and more preferably the corresponding central angles are also the same, that is, the third notches 33 are preferably cut by a plane perpendicular to the main spherical surface 99. .
- the above sounding surface 3 is a shape similar to a "C-shape" as viewed in a direction perpendicular to the main spherical surface 99, and the "C-shaped” in a direction perpendicular to the main spherical surface 99.
- the circular arc corresponding to the circular arc in the cross section parallel to the main spherical surface 99 is greater than 180 degrees and less than 300 degrees, and more It is preferably greater than 200 degrees and less than 280 degrees.
- the standing wave can be formed as long as the central angle is greater than 180 degrees and less than 360 degrees, from the practical point of view, the central angle is more preferably in the above range, so that it can form sufficient standing wave, and the third notch 33 is also Large enough for practical use.
- the spherical surface corresponding to the sounding surface 3 has a diameter of 100 mm to 3000 mm, more preferably 200 mm to 2000 mm.
- the higher the energy density of the focal region, and the spherical surface of the above size is more suitable for practical use.
- the sounding surface 3 is symmetrically disposed with respect to the main spherical surface 99.
- the sounding surface 3 is preferably symmetrically distributed with respect to the main spherical surface 99, that is, the form of the sound emitting surface 3 on both sides of the main spherical surface 99 is preferably the same, so that the sound field and the focal field formed are also relative to the main
- the spherical surface 99 is symmetrical, more regular and easy to control.
- the ultrasound emitted by the different sounding faces 3 is simulated below; wherein the first plane 91 and the second plane 92 of the sounding surface 3 for simulation are parallel to each other and equal to the distance from the main spherical surface 99, and are parallel to the main
- the spherical core surface 99 has a circular arc shape in cross section, and the circular core angles corresponding to the circular arc shapes are equal and oriented in the same direction.
- the simulated sound field intensity (represented by sound pressure, unit Pa) of the sound surface 3 above the central angle of 60 degrees, 100 degrees, 220 degrees, and 300 degrees, respectively, is as shown in FIG. 6 to FIG. 9 (wherein O is the center of the sphere, Y is the vertical direction, Z is the geometric center of the sounding surface 3, X is perpendicular to Y and Z, and the same is true.
- the focal region is obviously elliptical in the XOZ plane and the YOZ plane, and as the central angle increases, the long axis of the ellipse is shortened, but the change is not obvious.
- the focal field formed is a distinct cigar shape.
- the central angle exceeds 180 degrees, the shape of the focal region on the XOZ plane and the YOZ plane approaches a circle, so the focal region correspondingly becomes a regular shape close to a sphere.
- the focal length size can be significantly compressed in a partial direction, thereby making the focal length become approximately spherical.
- the simulated sound field intensity (represented by sound pressure, unit Pa) on each axis is as shown in FIG. 10 to FIG. 12, and the -6 dB width of the simulated sound field on each axis is as shown in FIG. Figure 13 shows the focal length of the -6dB width as shown in Figure 14.
- the focal field is significantly compressed on the X-axis and the Z-axis, especially on the Z-axis, and the focal length is compressed from approximately 5 wavelengths to approximately 1 wavelength.
- the size of the focal length on the X-axis, Y-axis, and Z-axis is basically the same, and the focal length changes from "cigar-shaped" to nearly spherical, and the volume is greatly reduced.
- the maximum sound pressure continues. Increase, which indicates that as the volume of the focal region shrinks, the energy density of the focal region increases significantly.
- the simulated sound field intensity (represented by sound pressure, in units of Pa) on each axis is as follows. As shown in Fig. 15 to Fig. 17, the -6 dB width of the simulated sound field on each axis is as shown in Fig. 18, and the focal length volume of -6 dB width is as shown in Fig. 19.
- the focal length size is also compressed, and the compression in the Y-axis direction is more pronounced, and accordingly, the focal volume is significantly reduced. This indicates that the distance between the first plane 91 and the second plane 92 is also influential.
- the embodiment provides a focused ultrasound therapy device, which includes:
- the above ultrasonic transducer can be combined with other components to form a device for treating disease using focused ultrasound.
- the focused ultrasound therapy device can emit ultrasound (eg, from outside the body) and focus the ultrasound on the diseased tissue such as liver cancer, breast cancer, kidney cancer, bone tumor, uterine fibroids, etc., thereby treating benign and malignant tumors.
- the focused ultrasonic therapeutic apparatus of the present embodiment adopts the above ultrasonic transducer, the ultrasonic propagation is less affected by uneven tissue in the human body, and the formed focal length is regular in shape, small in size, and high in energy density; Accurately locate the focal region in the diseased tissue, rapidly ablate the diseased tissue, improve the treatment efficiency and effect, and at the same time minimize the influence on the surrounding tissue, acoustic channel, etc., and improve safety.
- the shape and size of the ultrasonic transducer in the focused ultrasound treatment device may also be different, and the relative positional relationship between the sounding surface of the ultrasonic transducer and the human body may also be different.
- the sounding surface may be "sleeve" in a form similar to a "ring" outside a certain part of the human body (ie, the human body part passes through the first notch and the second notch); or, a part of the human body may pass through the third notch above. Enter the sound surface.
- a medium accommodating unit for maintaining a sound transmitting medium such as deaerated water
- a treatment bed for supporting the human body or the like may be provided for the convenience of treatment.
- a drive unit for driving the ultrasonic transducer and/or human motion can also be provided.
- an imaging unit such as B-mode ultrasound, CT, MRI or the like for real-time forming an image around the focal region may be provided.
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Abstract
Description
Claims (16)
- 一种超声换能器,包括发声单元和发声面,所述发声单元用于产生超声波,其特征在于,所述发声面为具有第一缺口、第二缺口、第三缺口的球面,其中,所述发声面对应的球面的一个球心面为主球心面,所述第一缺口和所述第二缺口分别位于垂直于所述主球心面的直径与所述球面的两个相交处,所述第三缺口连接所述第一缺口和所述第二缺口;在距离所述主球心面两侧分别一定距离的范围内,所述发声面在与所述主球心面平行的截面中为圆弧形,所述圆弧形的开口对应所述第三缺口,所述圆弧形对应的圆心角大于180度且小于360度;所述发声面具有反射超声的能力,且所述发声单元产生的超声波聚焦于所述发声面对应的球心。
- 如权利要求1所述的超声换能器,其特征在于,所述第一缺口和所述第二缺口的边缘分别位于第一平面和第二平面中。
- 如权利要求2所述的超声换能器,其特征在于,所述第一平面与所述第二平面均平行于所述主球心面。
- 如权利要求3所述的超声换能器,其特征在于,所述第一平面与所述第二平面间的距离在80mm~1000mm。
- 如权利要求4所述的超声换能器,其特征在于,所述第一平面与所述第二平面间的距离在150mm~500mm。
- 如权利要求3所述的超声换能器,其特征在于,所述第一平面与所述主球心面间的距离等于所述第二平面与所述主球心面间的距离。
- 如权利要求1所述的超声换能器,其特征在于,所述发声面在任意平行于所述主球心面的截面中均为圆弧形,所述圆弧形对应的圆心角大于180度且小于360度。
- 如权利要求7所述的超声换能器,其特征在于,所述发声面在任意平行于所述主球心面的截面中的圆弧形的开口朝向相同。
- 如权利要求8所述的超声换能器,其特征在于,所述发声面在任意平行于所述主球心面的截面中的圆弧形对应的圆心角相等。
- 如权利要求1所述的超声换能器,其特征在于,在距离所述主球心面两侧分别一定距离的范围内,所述发声面在与所述主球心面平行的截面中的圆弧形对应的圆心角大于180度且小于300度。
- 如权利要求10所述的超声换能器,其特征在于,在距离所述主球心面两侧分别一定距离的范围内,所述发声面在与所述主球心面平行的截面中的圆弧形对应的圆心角大于200度且小于280度。
- 如权利要求1所述的超声换能器,其特征在于,所述发声面对应的球面的直径在100mm~3000mm。
- 如权利要求12所述的超声换能器,其特征在于,所述发声面对应的球面的直径在200mm~2000mm。
- 如权利要求1所述的超声换能器,其特征在于,所述距离所述主球心面两侧分别一定距离的范围为距所述主球心面两侧分别40mm~500mm的范围。
- 如权利要求1所述的超声换能器,其特征在于,所述发声面相对于所述主球心面对称设置。
- 一种聚焦超声治疗设备,其特征在于,包括:权利要求1至15中任意一项所述的超声换能器。
Priority Applications (7)
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US16/963,286 US20220331615A1 (en) | 2018-01-22 | 2018-09-07 | Ultrasonic Transducer and Focused Ultrasound Treatment Device |
CA3088814A CA3088814C (en) | 2018-01-22 | 2018-09-07 | Ultrasonic transducer and focused ultrasound treatment device |
EP18900848.5A EP3744396A4 (en) | 2018-01-22 | 2018-09-07 | ULTRASONIC TRANSDUCER AND FOCUSED ULTRASOUND PROCESSING DEVICE |
RU2020127309A RU2753279C1 (ru) | 2018-01-22 | 2018-09-07 | Ультразвуковой преобразователь и устройство лечения сфокусированным ультразвуком |
SG11202006821TA SG11202006821TA (en) | 2018-01-22 | 2018-09-07 | Ultrasonic transducer and focused ultrasound treatment device |
KR1020207024085A KR102525434B1 (ko) | 2018-01-22 | 2018-09-07 | 초음파 트랜스듀서 및 집속 초음파 치료 기기 |
JP2020540420A JP6950098B2 (ja) | 2018-01-22 | 2018-09-07 | 超音波変換器、集束超音波治療装置 |
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CN201810059389.5 | 2018-01-22 | ||
CN201810059389.5A CN110064136B (zh) | 2018-01-22 | 2018-01-22 | 超声换能器、聚焦超声治疗设备 |
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US (1) | US20220331615A1 (zh) |
EP (1) | EP3744396A4 (zh) |
JP (1) | JP6950098B2 (zh) |
KR (1) | KR102525434B1 (zh) |
CN (1) | CN110064136B (zh) |
CA (1) | CA3088814C (zh) |
RU (1) | RU2753279C1 (zh) |
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CN110478633B (zh) * | 2019-09-02 | 2021-08-10 | 重庆医科大学 | 聚焦超声换能器的固定架及超声换能系统 |
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- 2018-01-22 CN CN201810059389.5A patent/CN110064136B/zh active Active
- 2018-09-07 SG SG11202006821TA patent/SG11202006821TA/en unknown
- 2018-09-07 US US16/963,286 patent/US20220331615A1/en active Pending
- 2018-09-07 EP EP18900848.5A patent/EP3744396A4/en active Pending
- 2018-09-07 KR KR1020207024085A patent/KR102525434B1/ko active IP Right Grant
- 2018-09-07 JP JP2020540420A patent/JP6950098B2/ja active Active
- 2018-09-07 WO PCT/CN2018/104603 patent/WO2019140927A1/zh unknown
- 2018-09-07 RU RU2020127309A patent/RU2753279C1/ru active
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CA3088814C (en) | 2023-07-11 |
EP3744396A1 (en) | 2020-12-02 |
JP6950098B2 (ja) | 2021-10-13 |
US20220331615A1 (en) | 2022-10-20 |
CA3088814A1 (en) | 2019-07-25 |
KR102525434B1 (ko) | 2023-04-26 |
RU2753279C1 (ru) | 2021-08-12 |
CN110064136B (zh) | 2024-04-19 |
EP3744396A4 (en) | 2021-10-13 |
SG11202006821TA (en) | 2020-08-28 |
CN110064136A (zh) | 2019-07-30 |
KR20200111744A (ko) | 2020-09-29 |
JP2021511740A (ja) | 2021-05-06 |
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