WO2019115658A1 - Procédé et appareil destinés à être utilisés pour détecter une simulation de maladie engagement par un premier sujet dans des essais de fonction physique et/ou mentale du premier sujet - Google Patents

Procédé et appareil destinés à être utilisés pour détecter une simulation de maladie engagement par un premier sujet dans des essais de fonction physique et/ou mentale du premier sujet Download PDF

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Publication number
WO2019115658A1
WO2019115658A1 PCT/EP2018/084650 EP2018084650W WO2019115658A1 WO 2019115658 A1 WO2019115658 A1 WO 2019115658A1 EP 2018084650 W EP2018084650 W EP 2018084650W WO 2019115658 A1 WO2019115658 A1 WO 2019115658A1
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WIPO (PCT)
Prior art keywords
subject
physical
malingering
mental function
function tests
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PCT/EP2018/084650
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English (en)
Inventor
Murray Fulton Gillies
Reza SHARIFI SEDEH
Daisy VAN MINDE
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Koninklijke Philips N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP18176671.8A external-priority patent/EP3579245A1/fr
Application filed by Koninklijke Philips N.V. filed Critical Koninklijke Philips N.V.
Priority to US16/756,635 priority Critical patent/US11786156B2/en
Publication of WO2019115658A1 publication Critical patent/WO2019115658A1/fr

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/70—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training

Definitions

  • the disclosure relates to the detection of malingering by a subject, and in particular to a method and apparatus for use in detecting malingering by a subject in tests of physical and/or mental function of the subject.
  • Clinical neuropsychology is the field of determining the cognitive functioning of a person by requiring them to perform various validated neuropsychological tests and, for example, scoring their ability to perform these tests against norm scores that are
  • Assessing cognitive functioning is relevant for various patient groups including dementia, stroke, traumatic brain injury, multiple sclerosis, depression, epilepsy and schizophrenia as well as for screening healthy populations. Due to the ageing population and the rapidly increasing prevalence of some of these diseases there is an increasing recognition of the importance of cognitive functioning and that it is necessary to be able to perform a neuropsychological assessment in an efficient and reproducible manner.
  • neuropsychological tests are typically either (i) paper-pencil tests, where the patient is asked to draw an object on paper or to complete a pre defined task which has been printed on the paper; (ii) auditory verbal tests, where the patient is asked to recall facts, number sequences or word groups and from these responses a score is calculated; and (iii) motor tasks where the patient is asked to complete a task that involves a physical activity such completing a puzzle or finger tapping.
  • Malingering is where a person intentionally underperforms in physical and/or mental function tests to fabricate or exaggerate symptoms of a physical condition and/or a mental condition, and is a common issue with neuropsychological assessments. It is important to recognize this intentional under performance so that subjects who are trying to deceive can be identified. For example, subjects with suspected traumatic brain injury may have an incentive to malinger due to a litigation case, where a poor performance in cognitive tests would help the subjects’ case in court. The same applies where a subject has (or appears to have) a physical injury.
  • MMPI Minnesota Multiphasic Personality Inventory
  • an apparatus for use in detecting malingering by a first subject in a test of physical and/or mental function of the first subject comprising a memory unit configured to store a plurality of models, each model identifies a respective set of physical and/or mental function tests from a plurality of different physical and/or mental function tests that can be used to detect malingering by a subject and that meets one or more possible user requirements for detecting malingering; and a processing unit configured to receive a user input from a user of the apparatus, the received user input indicating a user requirement for detecting malingering by the first subject;
  • the first aspect provides an apparatus that allows a user (e.g. neuropsychologist) to specify their requirements for detecting whether a first subject is malingering (e.g.
  • the additional test burden on the first subject is only incurred when malingering is suspected.
  • the one or more possible user requirements comprises a level of reliability of detecting malingering and/or a number of physical and/or mental function tests in a set.
  • the indication that the first subject may be malingering in the physical and/or mental function test is received from the user of the apparatus. In other embodiments, the indication that the first subject may be malingering in the physical and/or mental function test is received from the testing device. In yet other embodiments, the processing unit can be configured to receive the indication that the first subject may be malingering by receiving a signal from the testing device relating to the completion of a physical and/or mental function test by the first subject; and processing the received signal to detect whether the first subject may be malingering.
  • the processing unit is further configured to receive results for the first subject in completing the first set of physical and/or mental function tests; analyse the results to determine values for one or more parameters relating to the completion of each physical and/or mental function test in the first set by the first subject; and process the determined values to determine an indication of whether the first subject is malingering in one or more of the physical and/or mental function tests in the first set.
  • the processing unit is further configured to receive population information relating to a plurality of subjects, the population information comprising results for the plurality of subjects in completing the plurality of different physical and/or mental function tests and an indication of whether the subject was malingering; and process the received population information to determine the plurality of models.
  • population information relating to a plurality of subjects
  • the population information comprising results for the plurality of subjects in completing the plurality of different physical and/or mental function tests and an indication of whether the subject was malingering
  • process the received population information to determine the plurality of models.
  • the processing unit is further configured to receive user requirement information indicating a range of possible user requirements; and process the received population information and the received user requirement information to determine the plurality of models. In this way models will be available that cover different user requirements.
  • the processing unit is configured to process the received population information to determine the plurality of models using one or more artificial intelligence algorithms and/or one or more machine learning algorithms.
  • the processing unit is further configured to, in response to an indication indicating that the identified first set of physical and/or mental function tests did not detect whether the first subject is malingering, prompt the user of the apparatus to indicate a different user requirement for detecting malingering in the first subject; in response to receiving an indication of a different user requirement from the user, retrieve, from the memory unit, the identity of a second set of physical and/or mental function tests for a model in the plurality of models that meets the indicated different user requirement; and output a control signal to the testing device indicating the retrieved identity of the second set of physical and/or mental function tests such that the testing device provides the identified second set of physical and/or mental function tests to the first subject for completion to detect whether the first subject is malingering.
  • the apparatus can automatically adapt the testing process to detect malingering if an initial set of physical and/or mental function tests (the first set) did not provide a conclusion on whether the first subject is malingering.
  • the processing unit is further configured to, in response to an indication indicating that the identified first set of physical and/or mental function tests did not detect whether the first subject is malingering, determine that a difficulty level of one or more of the physical and/or mental function tests in the first set of physical and/or mental function tests is to be increased; and output a control signal to the physical and/or mental function testing device indicating the identity of the first set of physical and/or mental function tests and the increased difficulty level such that the testing device provides the identified first set of physical and/or mental function tests to the first subject for completion to detect whether the first subject is malingering.
  • the apparatus can automatically adapt the testing process to detect malingering if an initial set of physical and/or mental function tests (the first set) did not provide a conclusion on whether the first subject is malingering.
  • the apparatus further comprises the testing device.
  • the physical and/or mental function test(s) is/are cognitive function test(s).
  • a computer- implemented method for use in detecting malingering by a first subject in a test of physical and/or mental function of the first subject the method in a processing unit comprising:
  • each model identifies a respective set of physical and/or mental function tests from a plurality of different physical and/or mental function tests that can be used to detect malingering in a subject and that meets one or more possible user requirements for detecting malingering; receiving a user input from a user, the received user input indicating a user requirement for detecting malingering by the first subject; following receipt of an indication that the first subject may be malingering in one or more physical and/or mental function tests, retrieving, from the memory unit, the identity of a first set of physical and/or mental function tests for a model in the plurality of models that meets the indicated user requirement; and outputting a control signal to a testing device indicating the retrieved identity of the first set of physical and/or mental function tests such that the testing device provides the identified first set of physical and/or mental function tests to the first subject for completion.
  • the second aspect provides a method that allows a user (e.g. neuropsychologist) to specify their requirements for detecting whether a first subject is malingering (e.g. balancing the additional test burden on the first subject against the reliability of the malingering assessment), and for a suitable set of additional physical and/or mental function tests to be provided to the first subject if there is a suggestion that the first subject is malingering.
  • a user e.g. neuropsychologist
  • a suitable set of additional physical and/or mental function tests e.g. balancing the additional test burden on the first subject against the reliability of the malingering assessment
  • the one or more possible user requirements comprises a level of reliability of detecting malingering and/or a number of physical and/or mental function tests in a set.
  • the indication that the first subject may be malingering in the physical and/or mental function test is received from the user. In other embodiments, the indication that the first subject may be malingering in the physical and/or mental function test is received from the testing device. In yet other embodiments, a signal can be received from the testing device relating to the completion of a physical and/or mental function test by the first subject; and the received signal can be processed to detect whether the first subject may be malingering. These embodiments provide different ways for the malingering indication to be received.
  • the method further comprises receiving results for the first subject in completing the first set of physical and/or mental function tests; analysing the results to determine values for one or more parameters relating to the completion of each physical and/or mental function test in the first set by the first subject; and processing the determined values to determine an indication of whether the first subject is malingering in one or more of the physical and/or mental function tests in the first set.
  • the method further comprises receiving population information relating to a plurality of subjects, the population information comprising results for the plurality of subjects in completing the plurality of different physical and/or mental function tests and an indication of whether the subject was malingering; and processing the received population information to determine the plurality of models.
  • This embodiment provides that the models can be determined based on population information which can enable the models to be more reliable in detecting malingering in line with the indicated user requirement.
  • the method further comprises receiving user requirement information indicating a range of possible user requirements; and processing the received population information and the received user requirement information to determine the plurality of models. In this way models will be available that cover different user requirements.
  • the method comprises processing the received population information to determine the plurality of models using one or more artificial intelligence algorithms and/or one or more machine learning algorithms.
  • the method comprises, in response to an indication indicating that the identified first set of physical and/or mental function tests did not detect whether the first subject is malingering, prompting the user to indicate a different user requirement for detecting malingering in the first subject; in response to receiving an indication of a different user requirement from the user, retrieving, from the memory unit, the identity of a second set of physical and/or mental function tests for a model in the plurality of models that meets the indicated different user requirement; and outputting a control signal to the testing device indicating the retrieved identity of the second set of physical and/or mental function tests such that the testing device provides the identified second set of physical and/or mental function tests to the first subject for completion.
  • the method can automatically adapt the testing process to detect malingering if an initial set of physical and/or mental function tests (the first set) did not provide a conclusion on whether the first subject is malingering.
  • the method further comprises, in response to an indication indicating that the identified first set of physical and/or mental function tests did not detect whether the first subject is malingering, determining that a difficulty level of one or more of the physical and/or mental function tests in the first set of physical and/or mental function tests is to be increased; and outputting a control signal to the testing device indicating the identity of the first set of physical and/or mental function tests and the increased difficulty level such that the testing device provides the identified first set of physical and/or mental function tests to the first subject for completion.
  • the method can automatically adapt the testing process to detect malingering if an initial set of physical and/or mental function tests (the first set) did not provide a conclusion on whether the first subject is malingering.
  • the physical and/or mental function test(s) is/are cognitive function test(s).
  • a computer program product comprising a computer readable medium having computer readable code embodied therein, the computer readable code being configured such that, on execution by a suitable computer or processor, the computer or processor is caused to perform the method according to the second aspect and any embodiment thereof.
  • Fig. 1 is a block diagram of an apparatus and system according to an embodiment
  • Fig. 2 is a flow chart illustrating an exemplary method according to an embodiment
  • Fig. 3 shows a set of results for a cognitive function test
  • Fig. 4 shows a set of results for different cognitive function tests.
  • Fig. 1 shows a block diagram of an exemplary apparatus 2 that can be used in detecting malingering by a subject in tests of physical and/or mental function of the subject.
  • the apparatus 2 can also be used by the subject to perform or complete the tests of physical and/or mental function.
  • the apparatus 2 may be, or may comprise, a testing device for providing the physical and/or mental function tests.
  • the apparatus 2 may be configured to be connected to a testing device 4 that provides the physical and/or mental function tests to form a system 6 for detecting malingering by a subject during the physical and/or mental function testing.
  • the testing device 4 (or the apparatus 2 in the embodiments where the apparatus 2 is used to provide the physical and/or mental function tests) can comprise a device or component that is used store physical and/or mental function test material, that can output required physical and/or mental function test material to a subject or to a separate device belonging to or used by the subject (such as a computer, tablet, smartphone, television, etc.), and that is used to receive and analyse the results of the inputs by the subject in response to the presented test.
  • the testing device 4 can be self- contained device (e.g. a computer, laptop, tablet computer, smart watch, smartphone, etc.) that stores the physical and/or mental function test material, presents the test to the subject (e.g.
  • the testing device 4 can be a device or component (e.g. a computer, server, etc.) that stores the cognitive function test material, outputs the test material to a display device (e.g. a screen, a television, a smart phone, etc.), receives information representing the subject’s inputs in response to the presented test and analyses the results to provide a measure of the
  • the testing device 4 can be a server that provides the test material to a web browser or application on the other device, and the subject’s inputs returned to the server via the web browser or application for analysis and evaluation. It will be appreciated that the above embodiments also apply where the apparatus 2 is used to provide the cognitive function tests.
  • the apparatus 2 is an electronic device that comprises a processing unit 8 and a memory unit 10.
  • the processing unit 8 is configured or adapted to control the operation of the apparatus 2 and to implement the techniques described herein for detecting malingering by a subject.
  • the processing unit 8 can be configured to execute or perform the methods described herein.
  • the processing unit 8 can be implemented in numerous ways, with software and/or hardware, to perform the various functions described herein.
  • the processing unit 8 may comprise one or more microprocessors or digital signal processor (DSPs) that may be programmed using software or computer program code to perform the required functions and/or to control components of the processing unit 8 to effect the required functions.
  • DSPs digital signal processor
  • the processing unit 8 may be implemented as a combination of dedicated hardware to perform some functions (e.g.
  • the processing unit 8 is connected to a memory unit 10 that can store data, information and/or signals for use by the processing unit 8 in controlling the operation of the apparatus 2 and/or in executing or performing the methods described herein.
  • the memory unit 10 stores computer-readable code that can be executed by the processing unit 8 so that the processing unit 8, in conjunction with the memory unit 10, performs one or more functions, including the methods described herein.
  • the memory unit 10 can comprise any type of non- transitory machine-readable medium, such as cache or system memory including volatile and non-volatile computer memory such as random access memory (RAM) static RAM (SRAM), dynamic RAM (DRAM), read-only memory (ROM), programmable ROM (PROM), erasable PROM (EPROM), and electrically erasable PROM (EEPROM).
  • RAM random access memory
  • SRAM static RAM
  • DRAM dynamic RAM
  • ROM read-only memory
  • PROM programmable ROM
  • EPROM erasable PROM
  • EEPROM electrically erasable PROM
  • the apparatus 2 also includes interface circuitry 12 for enabling a data connection to and/or data exchange with other devices, including any one or more of servers, databases, user devices, and one or more testing devices 4.
  • the interface circuitry 12 can enable a connection between the apparatus 2 and a network, such as the Internet, via any desirable wired or wireless communication protocol.
  • the interface circuitry 12 can operate using WiFi, Bluetooth, Zigbee, or any cellular communication protocol
  • the interface circuitry 12 is connected to the processing unit 8.
  • the apparatus 2 comprises a user interface 14 that includes one or more components that enables a user of apparatus 2 to input information, data and/or commands into the apparatus 2, and/or enables the apparatus 2 to output information or data to the user of the apparatus 2.
  • the‘user’ of the apparatus can be a person, such as a neuropsychologist, that would like to determine if a test subject (referred to as a‘subject’ or‘first subject’ herein) is malingering.
  • the apparatus 2 includes or is part of a testing device, the subject can also be considered as a user of the apparatus 2.
  • the user interface 14 can comprise any suitable input component(s), including but not limited to a keyboard, keypad, one or more buttons, switches or dials, a mouse, a track pad, a touchscreen, a stylus, a camera, a microphone, etc., and the user interface 14 can comprise any suitable output component(s), including but not limited to a display screen, one or more lights or light elements, one or more loudspeakers, a vibrating element, etc.
  • the apparatus 2 can be any type of electronic device or computing device.
  • the apparatus 2 can be, or be part of, a server, a computer, a laptop, a tablet, a smartphone, etc.
  • an apparatus 2 may include additional components to those shown in Fig. 1.
  • the apparatus 2 may also include a power supply, such as a battery, or components for enabling the apparatus 2 to be connected to a mains power supply.
  • a problem in detecting malingering in physical and/or mental function tests is that it can be useful to add specific malingering-related tests to the current test battery (i.e. a set of tests to be performed) in order to detect the malingering, but these tests can take a long time to complete and increase the overall time required for completing the physical and/or mental function tests.
  • some tests may be useful in detecting some types of malingering, but not others.
  • the techniques described herein therefore provide an approach by which a set of physical and/or mental function tests can be identified and used to test a subject’s physical and/or mental function and also whether they may be malingering.
  • a physical function test can test any aspect of physical function of a subject, including the gross motor skills/ability of the subject (e.g. ability to walk steadily, lift objects, etc.) and the fine motor skills/ability of the subject (e.g. relating to the functioning of the hands or fingers).
  • a mental function test can test any aspect of mental function of a subject, including the cognitive functions of the subject, such as memory, perception, attention, motor skills, language, visual and spatial processing and executive functions.
  • a test can include one or more activities that the subject is to perform and/or one or more questions that the subject is to answer.
  • the flow chart in Fig. 2 shows a method for use in detecting malingering by a first subject according to various embodiments. Some or all of the steps in the method can be performed by the apparatus 2, for example by the processing unit 8 in conjunction with the memory unit 10. In that case, the processing unit 8 can be configured to perform the method, and/or the processing unit 8 can execute computer program code to cause the processing unit 8 to perform the method.
  • the method according to the techniques described herein makes use of models that identify respective sets of physical and/or mental function tests that can be used to detect malingering by a subject.
  • Steps 101-105 of the method in Fig. 2 relate to the generation of these models, and steps 107-117 relate to the selection and use of a model to detect malingering by the first subject.
  • the method is provided to identify respective sets of cognitive function tests that can be used to detect malingering by a subject in one or more cognitive function tests, and the following description can be interpreted accordingly.
  • step 101 population information is received that relates to a plurality of subjects.
  • the population information comprises results for the plurality of subjects in completing a plurality of different physical and/or mental function tests and an indication of whether the subject was malingering.
  • the population information can include results for subjects that were malingering and subjects that were not malingering.
  • the indication of whether a subject was malingering can be an indication that was provided by an assessor (e.g. neuropsychologist in the case of a mental and/or cognitive function assessment), provided by the results of a validated test for malingering or through an automated assessment of the performance for a test.
  • the population information may be received from memory unit 10, or from a memory unit (e.g. a database) that is separate from the apparatus 2.
  • step 102 user requirement information is received that indicates a range of possible user requirements for the models to be generated.
  • the user requirements can relate to expectations of design and performance of the risk score models for different scenarios when different sets of physical and/or mental function tests are used for malingering detection. These expectations can be, for example, the range of quality metric values derivable from the tests, the number of tests used in the model, a minimum set of tests that should be used (e.g. identifying specific tests that should be part of the model), the reliability of the malingering indication, etc.
  • the user can indicate that the models should have an AUC (area under the curve of a ROC (receiver operating characteristic) curve) of at least 85% or AUCs in the range 0.7 to 0.9, and/or that the maximum number of tests used in each scenario should be 15.
  • the user requirement information can be received from the user of the apparatus 2, for example via the user interface 14.
  • the received population information and the received user requirement information is processed to determine the plurality of models.
  • different scenarios are selected (e.g. each scenario having a respective set of values from the possible user requirements indicated in the user requirement information), and a set of physical and/or mental function tests are selected to form a model that meets the user requirements for each scenario.
  • the model will comprise or identify different physical and/or mental function test(s), which can be made up of physical and/or mental function test(s) of the same type but with different activities/questions (e.g. different arrangements of a set of numbers and/or letter in a trail making test, different mental arithmetic questions, etc.) and/or different types of physical and/or mental function tests (e.g.
  • the model can be understood as a group or compilation of tests, also referred to as a‘test battery’ or‘battery of tests’. In embodiments where tests may comprise one or more activities or questions, the model can be understood as a compilation of those one or more activities or questions into an overall test/test battery.
  • the processing unit 8 is configured to process the received population information and user requirement information to determine the plurality of models using one or more artificial intelligence algorithms and/or one or more machine learning algorithms.
  • the received population information will include information for two groups of subjects, those that were malingering and those that were not malingering.
  • the risk score models are trained using supervised machine learning algorithms (e.g., SLIM, Random Forest, Logistics Regression, Neural Networks, etc.) on these two groups to determine a set of physical and/or mental function tests that meet the user requirements for that scenario.
  • supervised machine learning algorithms e.g., SLIM, Random Forest, Logistics Regression, Neural Networks, etc.
  • Goal determine (Ao, Ac, ... , l R )
  • step 105 for example in memory unit 10.
  • the models are stored, along with their corresponding quality metric values, and the information on the relevant user requirements
  • steps 101-105 can be performed in a set up phase for the apparatus 2, and thus steps 101-105 are typically not repeated frequently or repeated each time that a first subject is having their physical and/or mental function tested.
  • the user can provide a user input indicating one or more user requirements for detecting malingering in the first subject during those physical and/or mental function tests (step 107).
  • This user input can be provided using the user interface 14.
  • the one or more user requirements can comprise a level of reliability of detecting malingering, a number of physical and/or mental function tests in a set and/or an identity of one or more specific physical and/or mental function tests that the user would like the first subject to take.
  • the user can provide user requirements indicating that the first subject is to take a subset of tests 1-20 such that the AUC of the risk score is greater than 85%.
  • the user can provide user requirements indicating another subset of tests that can be used.
  • Step 109 occurs following receipt of an indication that the first subject may be malingering in one or more physical and/or mental tests, and in step 109 the identity of a first set of physical and/or mental function tests for a model in the plurality of models that meets the user requirements indicated in step 107 is retrieved from the memory unit 10. That is, if there is an indication that the first subject may be malingering, the memory unit 10 is searched to find a model that meets the user requirements, and the set of tests that make up this model are identified.
  • the indication that the first subject may be malingering in the physical and/or mental test is received from the user of the apparatus 4, for example via the user interface 14.
  • the user may provide this indication in response to observing the results of the first subject performing one or more tests, or the user can provide this indication for a first subject that is already suspected of malingering.
  • the indication that the first subject may be malingering in the physical and/or mental test is received from the testing device 4 (for example in response to the analysis of the performance of one or more physical and/or mental function tests by the first subject using the device 4).
  • the processing unit 8 may receive a signal from the testing device 4 relating to the completion of one or more physical and/or mental function tests by the first subject (for example the signal can indicate the inputs by the first subject in performing the test), and the processing unit 8 can process the received signal to detect whether the first subject may be malingering.
  • the processing unit 8 can process the received signal to detect whether the first subject may be malingering.
  • steps 107 can be performed after an indication is received that the first subject may be malingering. This can enable the user (e.g. neuropsychologist) to adapt their user
  • the user can provide a user
  • step 109 may provide a model that requires the subject to only additionally take tests 1— 8, 10, and 13 and provide an AUC of 87%, or a model that uses all 20 tests with an AUC of 90%.
  • the apparatus 2 (processing unit 8) outputs a control signal to a testing device 4 indicating the identity of the first set of physical and/or mental function tests.
  • This control signal causes the testing device 4 to provide the identified first set of physical and/or mental function tests to the first subject for completion to detect whether the first subject is malingering.
  • the control signal can cause the testing device 4 to output the relevant physical and/or mental function test material to the subject’s device (e.g. to a web browser or application on a tablet, smartphone, etc.) for completion by the subject on that device.
  • Step 113 results are received for the first subject in completing the first set of physical and/or mental function tests (step 113).
  • Step 113 (and the subsequent steps) can be performed by the apparatus 2, but it will be appreciated that in alternative embodiments the analysis of the results of the tests can be performed by a separate apparatus or device.
  • the results can relate to the inputs provided by the first subject in completing the tests (e.g. the timing of each input, elements selected with the input, text/numbers input by the subject, etc.).
  • the processing unit 8 analyses the results to determine values for one or more parameters relating to the completion of each physical and/or mental function test in the first set by the first subject (step 115). For example, in step 115 the processing unit 8 can determine scores or other metrics relating to the completion of the tests (e.g. an indication of how many tasks were completed correctly, an indication of whether the pace that the test was completed was within a normal range, an overall score for the test, etc.). In some examples of scores or other metrics relating to the completion of the tests (e.g. an indication of how many tasks were completed correctly, an indication of whether the pace that the test was completed was within a normal range, an overall score for the test, etc.). In some examples of scores or other metrics relating to the completion of the tests (e.g. an indication of how many tasks were completed correctly, an indication of whether the pace that the test was completed was within a normal range, an overall score for the test, etc.). In some examples of scores or other metrics relating to the completion of the tests (e.g. an indication of how many
  • the processing unit 8 can analyse the results to determine values for parameters that can provide an indication of malingering (or not). As noted above, ways in which malingering can be identified from particular tests are known in the art, and further details of this processing are not provided herein.
  • Fig. 3 shows an exemplary set of results for one particular physical and/or mental function test, namely a digit span cognitive function test, with values for one or more parameters relating to the completion of the test.
  • Fig. 3 shows the first subject’s responses to several items, and indicates a score for each individual test element, a score for each item and an overall score.
  • step 113 the results for each test may be received in step 113 as that test is completed (i.e. before the next test is started) rather than receive the results for all tests at once.
  • the analysis of the results in step 115 can be performed as each set of test results is received, or step 115 can be performed once the results for all of the tests in the first set of tests are received.
  • the processing unit 8 can process the determined values to determine an indication of whether the first subject is malingering in one or more of the physical and/or mental function tests in the first set.
  • the indication of whether the first subject is malingering can be a malingering score (denoted DMI) or malingering percentage, and can be formed by combining the determined values for the set of tests performed by the first subject.
  • step 117 can be performed based on the results of the tests currently available, and step 117 can be repeated as more test results for the tests in the first set become available, which can improve the reliability of the indication of malingering over time.
  • the processing in step 117 can be performed in a number of different ways.
  • the determined values for the first subject can be compared to values determined for a population of healthy (and non-malingering) subjects, and pattern comparison algorithms used to determine a score indicating the level of similarity.
  • the apparatus 2 can have previously been calibrated against a recognised validated malingerer test, such as the F-scale in the MMPI, so that the determined values can be directly coupled to a probability of malingering.
  • weightings can be applied to determined values from different tests (for example based on how effective a particular test is at identifying malingering), and the weighted values combined to form the indication of whether the first subject is malingering.
  • the indication of whether the first subject is malingering can be output to the user using the user interface 14. This can be seen in Fig. 3.
  • the indication of whether the first subject is malingering can be compared to a threshold to determine if the first subject is malingering. For example, a malingering score above a threshold can indicate that the first subject is malingering, whereas a malingering score below the threshold can indicate that the first subject is not malingering, or that malingering has not been detected.
  • the user may decide to stop the physical and/or mental function testing of the first subject.
  • the processing unit 8 may determine that the physical and/or mental function testing of the first subject should be stopped, and the processing unit 8 can send a suitable control signal to the testing device 4 to stop the tests.
  • Fig. 4 shows a display output that can be provided to the user of the apparatus 2 that indicates the results of several different cognitive/mental function tests in the first set of tests.
  • the set of tests includes the digit span test, verbal fluency test, trail making test, Rey-0 test, O-search test and WCS test, and five malingering measures (P1-P5) are shown for each test, with the level of shading indicating the standard deviations away from the score expected for the subject if no malingering is present, along with the overall malingering score (DMI) and an optional display element that shows an indication provided by the user of the apparatus 2 as to whether the first subject is malingering.
  • DMI overall malingering score
  • test results can be treated accordingly by the user (e.g. the results can be considered as representative of the physical and/or mental function of the first subject).
  • the user can be requested or prompted to provide a different set of user requirements to those provided in step 107.
  • This request or prompt can be provided using the user interface 14.
  • the user can then provide an indication of a different user requirement, again via the user interface 14.
  • the different user requirement may be a different number of tests for the subject to take, different ones of the tests to include or exclude from the set of tests, a different malingering detection reliability, etc.
  • the identity of a second set of physical and/or mental function tests for a model that meets the indicated different user requirement can be retrieved from the memory unit 10. This step can be performed in a similar way to step 109 above.
  • a control signal is then output to the testing device 4 indicating the retrieved identity of the second set of physical and/or mental function tests (similar to step 111 above). Therefore the testing device 4 provides the identified second set of physical and/or mental function tests to the first subject for completion to detect whether the first subject is malingering.
  • the results of the second set of tests can be analysed in the same way as the results of the first set of tests as described above in steps 113-115.
  • step 117 if the indication determined in step 117 is inconclusive on whether the first subject is malingering, for example if the malingering score is quite high (but without exceeding a threshold) and/or the user is not able to make their own
  • the processing unit 8 can be configured to determine that a difficulty level of one or more of the physical and/or mental function tests in the first set of physical and/or mental function tests is to be increased. By increasing the difficulty level of the test, this may make it harder for a malingering subject to disguise their malingering behaviour. It is also possible to consider the response curve to varying difficulty level and from this deduce whether malingering is present. Those skilled in the art will be aware of ways in which the difficulty level of particular physical and/or mental function tests can be increased (or decreased), and further details are not provided herein.
  • the processing unit 8 can output a control signal to the testing device 4 indicating the identity of the first set of physical and/or mental function tests and the increased difficulty level.
  • the testing device 4 can therefore provide the identified first set of physical and/or mental function tests to the first subject at the increased difficulty level, and an indication of whether the first subject is malingering can be determined as described above.
  • the techniques described above provide that if there is any indication that a first subject may be malingering, a suitable set of physical and/or mental function tests are identified and used to test the first subject.
  • an overall indication of the malingering e.g. a score
  • the user e.g. neuropsychologist
  • the apparatus 2 can stop the tests if the overall indication of malingering exceeds a threshold (optionally also if a quality metric (e.g. AUC) for the malingering indication is above a threshold).

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Abstract

Selon un aspect, l'invention concerne un appareil destiné à être utilisé pour détecter une simulation de maladie par un premier sujet dans un test de fonction physique et/ou mentale du premier sujet. L'appareil comprend une unité de mémoire configurée pour mémoriser une pluralité de modèles, chaque modèle identifie un ensemble respectif d'essais de fonction physique et/ou mentale à partir d'une pluralité de différents essais de fonction physique et/ou mentale qui peuvent être utilisés pour détecter une simulation de maladie chez un sujet et qui satisfait une ou plusieurs exigences d'utilisateur possibles pour détecter une simulation de maladie; et une unité de traitement configurée pour recevoir une entrée d'utilisateur provenant d'un utilisateur de l'appareil, l'entrée d'utilisateur reçue indiquant une exigence d'utilisateur pour détecter une simulation de maladie chez le premier sujet; après la réception d'une indication selon laquelle le premier sujet peut être en train de simuler une maladie dans un ou plusieurs essais de fonction physique et/ou mentale, récupérer, à partir de l'unité de mémoire, l'identité d'un premier ensemble d'essais de fonction physique et/ou mentale pour un modèle qui satisfait l'exigence d'utilisateur indiquée; et délivrer en sortie un signal de commande vers un dispositif d'essai de fonction indiquant l'identité récupérée du premier ensemble d'essais de fonction physique et/ou mentale de telle sorte que le dispositif d'essai fournit le premier ensemble identifié d'essais de fonction physique et/ou mentale au premier sujet pour l'achèvement.
PCT/EP2018/084650 2017-12-13 2018-12-13 Procédé et appareil destinés à être utilisés pour détecter une simulation de maladie engagement par un premier sujet dans des essais de fonction physique et/ou mentale du premier sujet WO2019115658A1 (fr)

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US201762598128P 2017-12-13 2017-12-13
US62/598,128 2017-12-13
EP18176671.8 2018-06-08
EP18176671.8A EP3579245A1 (fr) 2018-06-08 2018-06-08 Procédé et appareil destinés à la detection de la simulation par un premier sujet dans des tests de fonction physique et/ou mentale du premier sujet

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050273017A1 (en) * 2004-03-26 2005-12-08 Evian Gordon Collective brain measurement system and method
US20150245789A1 (en) * 2012-09-07 2015-09-03 Medstar Health Research Institute, Inc. Method and system of rapid screening for mild traumatic brain injury (mtbi) and other cognitive impairment by analysis of intra-individual variability of motor performance
US20160022136A1 (en) * 2013-03-13 2016-01-28 The Henry M. Jackson Foundation for the Advance- ment of Military Medicine, Inc. Enhanced neuropsychological assessment with eye tracking
US20160213298A1 (en) * 2001-12-27 2016-07-28 U.S. Army Medical Reserach and Material Command Neurocognitive and psychomotor performance assessment and rehabilitation system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160213298A1 (en) * 2001-12-27 2016-07-28 U.S. Army Medical Reserach and Material Command Neurocognitive and psychomotor performance assessment and rehabilitation system
US20050273017A1 (en) * 2004-03-26 2005-12-08 Evian Gordon Collective brain measurement system and method
US20150245789A1 (en) * 2012-09-07 2015-09-03 Medstar Health Research Institute, Inc. Method and system of rapid screening for mild traumatic brain injury (mtbi) and other cognitive impairment by analysis of intra-individual variability of motor performance
US20160022136A1 (en) * 2013-03-13 2016-01-28 The Henry M. Jackson Foundation for the Advance- ment of Military Medicine, Inc. Enhanced neuropsychological assessment with eye tracking

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