WO2019113653A1 - Capsule à deux sections pour substances médicamenteuses - Google Patents

Capsule à deux sections pour substances médicamenteuses Download PDF

Info

Publication number
WO2019113653A1
WO2019113653A1 PCT/AZ2017/000008 AZ2017000008W WO2019113653A1 WO 2019113653 A1 WO2019113653 A1 WO 2019113653A1 AZ 2017000008 W AZ2017000008 W AZ 2017000008W WO 2019113653 A1 WO2019113653 A1 WO 2019113653A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
lid
partition
drug
parts
Prior art date
Application number
PCT/AZ2017/000008
Other languages
English (en)
Russian (ru)
Inventor
Эльдар Бахрам Оглы Сариев
Лейла Эльдар САРЫ
Бахрам Эльдар САРИЕВ
Original Assignee
Эльдар Бахрам Оглы Сариев
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эльдар Бахрам Оглы Сариев filed Critical Эльдар Бахрам Оглы Сариев
Priority to PCT/AZ2017/000008 priority Critical patent/WO2019113653A1/fr
Publication of WO2019113653A1 publication Critical patent/WO2019113653A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Definitions

  • the present utility model relates to new, multi-part capsules for pharmaceutical preparations intended for oral administration of two incompatible drugs.
  • Hard capsules or bivalves consist of two cylindrical parts that are telemetrically inserted into each other: bodies with a hemispherical base and a lid of the same shape but shorter. The inner diameter of the cap is actually equal to the diameter of the case.
  • Capsules are usually made from gelatin.
  • capsules are made of; Hemmed from well-digestible water-soluble plastics that provide, when taken orally, the release of active substances in certain parts of the gastrointestinal tract.
  • BP 0460921 describes capsules consisting of two parts, consisting of chitosia starch, cereal flour, oligosaccharides, methyl acrylate, methacridic acid, acetate, succinate, or hydroxypropionimetry dacellose phthalate. Capsule material is different in that its contents are released only in the large intestine.
  • OV 938828 describes capsules for radioactive substances used in therapy or diagnosis. Such capsules are made from water-soluble gelatin, cellulose cellulose, novnimido alcohol or non-toxic water-soluble thermoplastics.
  • RU 96115307 A (27, 10, 1998 PCT (TB 94/02703, A61 K 9/48) claims a pharmaceutical form in the form of two-phase capsules, comprising a capsule having one compartment containing at least two filling compositions, characterized by what prevents the compositions from mixing with each other.
  • the two compositions are separated: a physical septum, which contains an additional closure of a material that is different from the material of the capsule.
  • the material of the partition contains a material having a melting point
  • the pharmaceutical form may include a first filling composition containing a pharmaceutically active substance for a short release when not pareteralny administered, and a second filling composition containing a pharmaceutically active substance for a prolonged release when administered parenterally.
  • the pharmaceutical form may include a first filling composition containing a biologically active substance, and a second filling composition containing a substance adapted to bring the pH of the intestine to a pH value of from 7.5 to 9.
  • the encapsulated drug is claimed.
  • the capsule body has inside two or more compartments separated by a partition for pharmaceutical compositions.
  • Known utility model [YAN 98132 U1, A61 K 9/48, A611C 31/4409. 10.10.2010], which is a solid capsule of an anti-tuberculosis drug, consisting of a solid gelatin detachable shell, made in the form of a body and a lid, in which terizidone granules and a tablet of niridoxine hydrochloride are coated, coated, the jerks of this fissile granule and pirndkoine hydrochloride tablet are made in therapeutically affective amounts and contain auxiliary pharmaceutically acceptable substances.
  • the disadvantage of the capsules described in the prior art is that they release the contents of the capsules in one specific section of the gastrointestinal tract.
  • the objective of the invention is to isolate incompatible pharmaceuticals in a single capsule, which can provide a prolonged release of a specific pharmaceutical agent in the desired part of the gastrointestinal tract, as well as to simplify the design of the capsule while maintaining its integrity.
  • the declared two-section capsule for medicinal substances which has a solid rim, made in the form of connected parts of the body and the cover, and of which the body is made from two the sides are open and with an integral partition inside, which divides it into two lengths for loading the medicinal substance into both parts of the capsule
  • the lid is cylindrical with an open horseback on one side and a closed part spherically with an end on the other, while the body is from the open ends, not far from the edge, grooved with the groove but the outer perimeter of the cylinder, and the lid is made with a protrusion along the inner perimeter closer to the closed hemispherical end, forming a “lock” that provides mutual interlocking of the body and the lid.
  • the body, lid and partition are made gastro-soluble with a prolonged drug release in one part, or the body, the lid and partition are made intestine-soluble with a prolonged drug release in one part, or one part of the capsule is made gastro-soluble and the other ⁇ intestinal para f f vorimoy.
  • the partition is made of gastro-soluble and enteric)> th and can be placed inside the body, forming different volumes of medicinal substances,
  • Figure 1 shows the capsule, a general view; figure 2 is the same, a longitudinal section; on fsh ⁇ 3 - body, in longitudinal section; figure 4 - cover.
  • the capsule has a hard shell (figure 1, figure 2), made in the form of a cylindrical body 1 about a partition 2 inside and connected to the case on both sides of the cover 3.
  • the case 1 (fig.Z) is open on both sides and with a one-piece partition 2 inside, which is made of it in two lengths for loading the drug into both parts of the capsule.
  • the cover 3 (FIG. 4) is cylindrical with an open condom on one side and a closed hemispherical end on the other.
  • Case 1 from the side of the open ends, close to the edge, is made with a groove along the outer perimeter of the cylinder, and the lid is made with a protrusion along the inner perimeter closer to the closed hemispherical end, forming a “lock” that provides mutual interlocking of the case and the lid.
  • the capsule is made in a conventional manner by dipping into the solution gelatin fingers that have the shape of a lid, body and partition for drying gelatin on the fingers with an aaoc-cutting of blanks of the required length.
  • Other pharmaceutical acceptable hydrophilic polymers can be used as capsules.
  • a plasticizer sorbitol
  • a capsule mass is injected into the capsule mass or applied to the surface of the capsule an enteric or intramuscular capsule.
  • Hard gelatin capsules of irodogirovany action obtained by introducing special ingredients (acrylic polymers, cellulose derivatives) in the composition of the filler product. Used combinations of substances prevent the rapid release of the active components of the capsule.
  • the capsule is filled as follows. Case 1 is filled with a dosed amount of one drug, tightly worn the lid 2 with a “lock” lock, turn it over, fill it with the dosed amount of another doctor from the opposite open end of the case! The agent can be closed tightly with lid 2 “locking” the capsule.
  • the capsule can be made gastro-soluble (ga-merciful), or enteric-guaranty (shpooooooooyinoy.) with a prolonged release of one of its parts, or enteric soluble is another.

Abstract

Le modèle d'utilité de l'invention se rapporte à des capsules à deux sections pour des préparations pharmaceutiques à prise orale. L'invention concerne une capsule à deux sections pour substances médicamenteuses comprenant une enveloppe solide se présentant sous forme de parties à connecter d'un corps et d'un couvercle, dans laquelle le corps est ouvert des deux côtés et comporte une cloison interne inamovible qui le sépare en deux longueurs pour charger une substance médicamenteuse dans les deux parties de la capsule; le couvercle est cylindrique avec une extrémité ouverte d'un côté et une extrémité hémisphérique close de l'autre; le corps, du côté des extrémités ouvertes et non loin du bord, comprend une gorge suivant le périmètre externe du cylindre, et le couvercle comporte une protubérance sur le périmètre interne à proximité de l'extrémité hémisphérique close, formant ainsi un verrou assurant le blocage mutuel du corps et du couvercle. Cette capsule peut être soluble dans l'estomac ou soluble dans l'intestin avec une diffusion prolongée de la substance médicamenteuse depuis une des parties, ou une partie de la capsule est soluble dans l'estomac et l'autre est soluble dans l'intestin.
PCT/AZ2017/000008 2017-12-11 2017-12-11 Capsule à deux sections pour substances médicamenteuses WO2019113653A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/AZ2017/000008 WO2019113653A1 (fr) 2017-12-11 2017-12-11 Capsule à deux sections pour substances médicamenteuses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/AZ2017/000008 WO2019113653A1 (fr) 2017-12-11 2017-12-11 Capsule à deux sections pour substances médicamenteuses

Publications (1)

Publication Number Publication Date
WO2019113653A1 true WO2019113653A1 (fr) 2019-06-20

Family

ID=66818789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AZ2017/000008 WO2019113653A1 (fr) 2017-12-11 2017-12-11 Capsule à deux sections pour substances médicamenteuses

Country Status (1)

Country Link
WO (1) WO2019113653A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4449983A (en) * 1982-03-22 1984-05-22 Alza Corporation Simultaneous delivery of two drugs from unit delivery device
US4738817A (en) * 1983-11-17 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from hydrophilic polymers
WO2001036290A1 (fr) * 1999-11-17 2001-05-25 Reckitt Benckiser (Uk) Limited Contenants solubles dans l'eau moules par injection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4449983A (en) * 1982-03-22 1984-05-22 Alza Corporation Simultaneous delivery of two drugs from unit delivery device
US4738817A (en) * 1983-11-17 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from hydrophilic polymers
WO2001036290A1 (fr) * 1999-11-17 2001-05-25 Reckitt Benckiser (Uk) Limited Contenants solubles dans l'eau moules par injection

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