WO2019108008A1 - Emulsion composition comprising amphiphilic anisotropic powder and having improved stability - Google Patents

Abstract

Disclosed is an emulsion composition comprising a material having a positive potential, a material having a negative potential, and a double spheroidal polymer amphiphilic anisotropic powder composed of one side with hydrophilicity and the other side with hydrophobicity, wherein the powder has a structure in which the other side with hydrophobicity partially infiltrates into the inside of the one side with hydrophilicity to form a core of the one side with hydrophilicity, a shell of the one side with hydrophilicity comprising a functional group, and wherein the emulsion composition comprises two phases, the phases having potentials opposite to each other.

Description

An emulsion composition comprising an amphiphilic anisotropic powder and having improved stability

The present disclosure relates to emulsified compositions comprising a substance having a positive potential, an amphiphilic anisotropic powder, and a substance having a negative potential.

In an emulsification system using a surfactant, an aqueous emulsion is formed by mixing an aqueous phase with an aqueous phase according to the HLB (Hydrophile-Lipophile Balance) value of the surfactant to emulsify the internal phase and the external phase.

It has been difficult to form a dual emulsion type emulsion using a conventional surfactant because it can be realized only at a composition ratio of a ternary system (water, oil, surfactant) and is difficult to stabilize due to the fluidity of emulsified interface film.

The size and shape of the spherical fine particles made of the polymer are controlled according to the manufacturing method, and thus the application possibility is expanded. One of its applications is Pickering emulsion which can form stabilized macroporous particles using micro spherical particles. O / W emulsified particles are formed at a contact angle of 90 ° or more, and W / O emulsion particles are formed at a temperature of 90 ° or less depending on the degree of hydrophilicity / hydrophobicity of the spherical particles.

Attempts have been made to produce new anisotropic powders by imparting amphiphilic properties, both hydrophilic and hydrophobic, to the microspheres. An example is the Janus spherical particles. However, due to the morphological limitations of these spheres, there is a limit to the chemical anisotropy. In other words, although it is morphologically anisotropic, it is totally hydrophobic or hydrophilic, so that there is a limit to chemical anisotropy.

It has been attempted to produce anisotropic powders having surface activity by imparting chemical anisotropy together with geometric shape control. However, despite the advantage of its applicability of amphiphilic anisotropic powder, up to now, Has not been specifically developed, and there is a problem that it is difficult to mass-produce uniformly in the industry, so that no practical industrial application has been made.

From the viewpoint of one aspect, a problem to be solved by the present invention is to provide an emulsified composition excellent in emulsion stability.

In another aspect, a problem to be solved by the present invention is to provide an emulsified composition including an amphiphilic anisotropic powder and having excellent stability at a low viscosity with time.

In one aspect, the present invention provides an emulsified composition comprising a substance having a positive potential, a substance having a negative potential, and a bispolide amphiphilic anisotropic powder having a hydrophilic one-side and a hydrophobic side, wherein the powder has a hydrophobic other side Wherein the hydrophilic one of the shells comprises a functional group, the emulsion composition comprises two phases, and the phases have mutually opposite electric potentials, Thereby providing an emulsified composition.

In one aspect, the present invention can provide an emulsified composition having excellent low viscosity emulsion stability.

From another viewpoint, the present invention can provide an emulsified composition having an excellent stability at a low viscosity including an amphiphilic anisotropic powder.

1 is a schematic diagram for forming an amphiphilic anisotropic powder according to an embodiment of the present invention.

FIG. 2 shows the pH-dependent change of the aqueous phase of hexyldecyl myristoyl methyl aminopropionate (HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE) according to an embodiment of the present invention.

FIG. 3 is a graph showing the difference in thin film formation according to the degree of neutralization of the increment agent of hexyldecyl myristoyl methyl aminopropionate (HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE) according to an embodiment of the present invention.

Fig. 4 shows the results of comparing emulsion formation differences according to the presence or absence of electric potential of the oil phase of the compositions of Reference Example 10 and Reference Example 9. Fig. The left side is the reference example 10, and the right side is the reference example 9. [

FIG. 5 is a graph showing that the (-) z-potential value of the amphiphilic anisotropic powder shifts in the (+) z-potential direction while bonding with the emollient, confirming that the amphiphilic anisotropic powder binds with the emollient Lt; / RTI > The red color in the lower graph is the z-potential value when bound with hexyldecyl myristoyl methylaminopropionate under the same conditions as the amphoteric anisotropic powder, and the green is the value when the pH is adjusted.

6A is a schematic view of an emulsified particle using only a substance having a positive potential and a substance having a negative potential.

FIG. 6B is a schematic diagram of emulsified particles of an emulsified composition comprising a substance having a positive potential, a substance having a negative potential, and an amphiphilic anisotropic powder according to an embodiment of the present invention. FIG.

7A is a photomicrograph of the emulsified particles after 4 weeks of preparation of the composition using only the carbomer of Comparative Example 1 and hexyldecyl myristoyl methyl aminopropionate (HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE).

FIG. 7B is a photomicrograph of the emulsified particles after four weeks of preparation of a composition containing the carbomer, hexyldecyl myristoyl methyl aminopropionate (HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE) and amphipathic anisotropic powder of Example 1. FIG.

7C is a photomicrograph of the emulsified particles after 4 weeks of preparation of the composition containing the carbomer of Comparative Example 2. Fig.

Hereinafter, embodiments of the present invention will be described in more detail. However, the techniques disclosed in the present application are not limited to the embodiments described herein but may be embodied in other forms. It should be understood, however, that the embodiments disclosed herein are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit and scope of the invention.

In one aspect of the present invention, there is provided an emulsified composition comprising a substance having dislocations, and a double spiroid type polymeric amphipathic powder comprising a hydrophilic one-side and a hydrophobic one, wherein the powder has a hydrophobic side partially embedded in the hydrophilic one side Wherein the hydrophilic one of the shells comprises a functional group, the emulsion composition comprises two phases, and the phases have mutually opposite electric potentials.

The substance having the dislocation may include at least one of a substance having a positive potential and a substance having a negative potential.

In one embodiment, the present invention provides an emulsified composition comprising a substance having a positive potential, a substance having a negative potential, and a bispolide amphiphilic anisotropic powder comprising a hydrophilic one-side and a hydrophobic one, Wherein the hydrophilic one of the shells comprises a functional group, the emulsion composition comprises two phases, and the phase comprises an emulsifying composition having a mutual potential opposite to that of the other, .

The two phases may include an aqueous phase and an oil phase. The emulsion composition may include, for example, W / O, O / W phase, but is not limited thereto.

Since the two phases of the emulsion composition have mutual dislocations, the interface is stabilized due to interactions between charges, so that the coagulation, fusion, or creaming of the emulsion particles in the emulsion composition can be prevented.

In one aspect, the substance having the positive potential may include an emollient, and the substance having the negative potential may include an increasing agent.

In one aspect, the emulsifying composition may be in water or in water. Specifically, the emulsified composition may be a water-in-oil type.

The substance having the positive potential can interact with the substance having the negative potential to form a film. Since the two phases contain a material having opposite potentials, the two phases exhibit opposite potentials and exhibit charge interactions at the interface between the two phases. Figure 6a shows the formation of regions (denoted in the figure as ion charge interaction zones) in the formulations containing materials having opposite potentials in two phases, representing interactions between the charges at the interface. It is possible to exhibit excellent interfacial stability by the film formed in the region showing the interaction between the charges.

6B is a schematic diagram of a formulation in which an amphiphilic anisotropic powder is present in a film formed in a region showing charge-charge interaction. The amphipathic anisotropic powder can form stable emulsified particles by having the hydrophobic part and the hydrophilic part have different directions to the interface. The emulsion particle formed by introducing an amphiphilic anisotropic powder into the interfacial membrane increases the thickness of the interfacial membrane to several hundreds nm, while the interfacial film formed by the general molecular-level surfactant forms a dynamic emulsion state. A solid interfacial film is formed. In addition, an amphiphilic anisotropic powder is introduced into the stabilized interface through the interaction with the charge, so that a more stable emulsified composition can be formed.

In one example, the amphiphilic anisotropic powder may be present at the interface with the substance having the disposition. For example, an amphiphilic anisotropic powder may be combined with a substance having a positive potential. The emulsion stability can be improved through the formation of the interfacial film, and the emulsion composition according to the present invention can have more stability. The emulsified particles according to the present invention can form a stable emulsified formulation in a wide range of viscosity and can provide a soft feeling feeling with a low viscosity.

The substance having a positive potential can be any substance exhibiting a positive potential, but can include, for example, a emollient having a positive potential, and can include, for example, a compound containing an amine group .

In one aspect of the present invention, the substance having a positive potential may include at least one selected from an aliphatic amine compound, an aromatic amine compound and an amine group-containing silicone compound.

The compound containing an amine group may be, for example, a compound having a functional group such as -N═, -NH-, -NH 2, or the like. For example, a compound having a functional group such as an aliphatic amine compound, an aromatic amine compound, But are not limited to, species. For example, the compound containing an amine group may be an alkylamine containing a linear or branched alkyl group having 6 to 30 carbon atoms, an aliphatic amine compound such as an alkanolamine containing a linear or branched alkanol group having 6 to 30 carbon atoms, , aromatic amine compounds such as o-toluidine, 2,4,6-trimethylaniline, anisidine and N-methylaniline, bisamodimethicone, amodimethicone, aminopropyldimethicone ( aminopropyl dimethicone), and the like. For example, one selected from the group consisting of Hexyldecyl Myristoyl Methylaminopropionate, Bis amodimethicone, amodimethicone, and aminopropyl dimethicone. It can be more than a species.

In one aspect, the substance having the positive potential may be contained in the oil phase of the emulsified composition.

In one aspect of the present invention, the emulsified composition may contain 0.01% to 75% by weight of the substance having the positive potential relative to the total weight of the composition. When the material having a positive potential is included in the above range, emulsion stability can be excellent, and stability with time can be excellent especially at a low viscosity. At least 0.01% by weight, at least 0.05% by weight, at least 0.1% by weight, at least 0.5% by weight, at least 1% by weight, at least 2% by weight, at least 4% by weight, at least 6% by weight, at least 8% At least 12 wt%, at least 14 wt%, at least 16 wt%, at least 18 wt%, at least 20 wt%, at least 22 wt%, at least 24 wt%, at least 26 wt%, at least 28 wt% At least 32 wt%, at least 34 wt%, at least 36 wt%, at least 38 wt%, at least 40 wt%, at least 42 wt%, at least 44 wt%, at least 46 wt%, at least 48 wt% 75 wt% or less, 74 wt% or less, 72 wt% or less, 70 wt% or less, 68 wt% or less, 66 wt% or less, 64 wt% or less, 62 wt% or less, Up to 60 wt%, up to 58 wt%, up to 56 wt%, up to 54 wt%, up to 52 wt% up to 50 wt% up to 48 wt% up to up to 46 wt% up to up to 42 wt% 40 wt% or less, 38 wt% or less, Up to 36 weight percent, up to 34 weight percent, up to 32 weight percent, up to 30 weight percent, up to 28 weight percent, up to 26 weight percent, up to 24 weight percent, up to 22 weight percent, or up to 20 weight percent .

The substance having a negative electric potential may be any substance exhibiting a negative electric potential, but may include an aging agent having a negative electric potential, for example, an anionic polymer.

The anionic polymer compound may be, for example, a polymer compound having a carboxylic acid group, a sulfonic acid group, a sulfuric acid ester group, or a phosphoric acid ester group as a functional group. For example, it may be selected from an acrylic acid polymer, a polysaccharide polymer and a sulfonic polymer But is not limited thereto. For example, the anionic polymer compound may be selected from the group consisting of polyacrylic acid, polymethacrylic acid, polymethylmethacrylic acid, methylmethacrylate-acrylic acid copolymer, vinylpyrrolidone-acrylic acid copolymer, hydroxyethyl acrylate / sodium acrylate An acrylic acid polymer such as a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, an acrylate / C10-30 alkyl acrylate cross polymer (ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER), a carbomer, Polysaccharide polymer compounds such as alginic acid, pectin and polygalacturonic acid, and sulfonic acid-based polymer compounds such as polystyrene sulfonic acid. For example, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, acrylate / C10-30 alkyl acrylate crosspolymer (ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER), acrylate / And carbomers may be used. In one embodiment, the material having a negative potential may be a carbomer.

In one embodiment, the material having a negative potential may have a pH of 7 or less and lower the pH of the overall composition. For example, the carbomer may lower the pH of the overall composition.

In one aspect, the substance having the negative electric potential may be contained in the water phase of the emulsified composition.

In one aspect of the present invention, the emulsified composition may contain 0.01 to 10% by weight of the substance having the negative potential with respect to the total weight of the composition. Preferably from 0.1 to 0.4% by weight, based on the total weight of the composition. Within this range, the emulsified composition may have excellent stability at low viscosity.

For example, at least 0.01%, at least 0.05%, at least 0.1%, at least 0.15%, at least 0.2%, at least 0.25%, at least 0.30%, at least 0.35%, at least 0.4% At least 0.5% by weight, at least 0.6% by weight, at least 0.7% by weight, at least 0.8% by weight, at least 0.9% by weight, at least 1.0% by weight, at least 1.5% by weight, at least 2.0% by weight, at least 2.5% At least 3.5 wt%, at least 4.0 wt%, at least 4.5 wt%, at least 5.0 wt%, at least 5.5 wt%, at least 6.0 wt%, at least 6.5 wt%, at least 7.0 wt%, at least 7.5 wt% Up to 9.5 wt.%, Up to 9.0 wt.%, Up to 8.5 wt.%, Up to 8.0 wt.%, Up to 7.5 wt.%, Up to 7.0 wt.% Up to 6.5 wt.%, Up to 6.0 wt.%, Up to 5.5 wt.%, Up to 5.0 wt.%, Up to 4.5 wt.%, Up to 4.0 wt.%, Up to 3.5 wt. Not more than 2.0%, not more than 1.5%, not more than 1.0%, not more than 0.9%, not more than 0.8%, not more than 0.7%, not more than 0.6%, not more than 0.5%, not more than 0.45%, not more than 0.4% Up to 0.35 weight percent, up to 0.30 weight percent, up to 0.25 weight percent, up to 0.20 weight percent, up to 0.15 weight percent, up to 0.1 weight percent, or up to 0.05 weight percent.

In one aspect of the present invention, the emulsified composition may have a pH of 7 or less, for example, a pH of 3 to 7. Within this range, the emulsified composition may have excellent stability at low viscosity.

For example, the emulsified composition may have a pH of less than 7, less than pH 6.5, less than pH 6, less than pH 5.5, less than pH 5, less than pH 4.5, less than pH 4.0, or less than pH 3.5, PH 4.0 or higher, pH 4.5 or higher, pH 5.0 or higher, pH 5.5 or higher, pH 6.0 or higher, or pH 6.5 or higher.

In one example, the magnitude of the positive potential of a substance having a positive potential may vary depending on the pH of the composition, for example, the lower the pH, the larger the potential.

In one aspect, the bispulo-type polymeric amphipathic anisotropic powder may be present at the interfaces of the two phases.

In the present embodiment, the amphiphilic anisotropic powder may be a double-sphere type polymeric amphipathic anisotropic powder consisting of a hydrophilic one-side and a hydrophobic one.

The powder may have a structure in which the hydrophobic other part partially penetrates into the inside of the hydrophilic one to form a hydrophilic one of the cores, and the hydrophilic one may include a functional group.

In one example, the amphiphilic anisotropic powder includes a hydrophilic one (first polymer spoloid) and a hydrophobic other (second polymer spoloid), the hydrophilic one having a core-shell structure, the hydrophobic one having a hydrophilic one- At least partially penetrating into the inside of the hydrophilic core to form a hydrophilic one of the cores, and the hydrophilic one shell may contain a functional group.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic view showing the principle of formation of an amphiphilic anisotropic powder according to an embodiment of the present invention. FIG. The core of the first polymer spolide may be formed through the shell of the first polymer spolide and may be grown to form a second polymer spoloid by the above manufacturing method.

The powder may be in the form of a double sparoid, that is, a three-dimensional nephroid having a shape in which two spheroids are combined, and a symmetrical shape, asymmetric snowman snowman-shaped or asymmetric inverse snowman shape. The shape of the snowman means that the first and second polymer spheroids having different sizes are combined.

The spheroid may be, for example, a sphere, a globoid, or an oval shape, and may have a major axis length in microns or nanometers based on the longest length in the body cross-section. have.

In one embodiment, the hydrophilic one may be a core-shell structure in which the core is made of the same polymer as the hydrophobic base, and the hydrophilic one and the hydrophobic one may each take one spoloid shape of the double spoil. The binding portion between the two sphereoids of the double sphere may have a continuous structure from the hydrophilic core to the hydrophobic one.

In one embodiment, the hydrophilic one-side core and the hydrophobic one include a vinyl polymer, and the hydrophilic one-side shell may include a copolymer of a vinyl monomer and a monomer containing a functional group.

In one example, the vinyl polymer may be a vinyl aromatic polymer, and may be, for example, polystyrene.

In one example, the vinyl monomer may be vinyl aromatic. In one example, the vinyl monomer may be substituted or unsubstituted styrene.

In one example, the functional group may be a siloxane.

In one embodiment, the functional group-containing monomer may be a siloxane-containing (meth) acrylate, and specifically includes 3- (trimethoxysilyl) propyl acrylate, 3- (trimethoxysilyl) propyl methacrylate, vinyl Triethoxysilane, vinyltrimethoxysilane, or a mixture thereof.

In one embodiment, the hydrophilic one-side shell may further include a hydrophilic functional group.

In one embodiment, the hydrophilic functional group may be a functional group having a negative or positive potential or a PEG (polyethylene glycol) group, and may be a carboxylic acid group, a sulfonic group, a phosphate group, an amino group, an alkoxy group, an ester group, an acetate group, a polyethylene glycol group, And a hydroxyl group.

In one embodiment, the hydrophilic one-side shell may further include a sugar-containing functional group.

In one embodiment, the functional group containing the sugar is selected from the group consisting of N- {N- (3-triethoxysilylpropyl) aminoethyl} gluconamide, N- (3-triethoxysilylpropyl) - (3-triethoxysilylpropyl) aminoethyl} -oligo-hyaluronamide, and the like.

In one embodiment, the amphiphilic anisotropic powder may have a particle size of 100 to 1500 nm. For example, the amphiphilic anisotropic powder may have a particle size of 100 to 500 nm, or 200 to 300 nm. Specifically, the amphiphilic anisotropic powder preferably has a particle size of 100 nm or more, 200 nm or more, 300 nm or more, 400 nm or more, 500 nm or more, 600 nm or more, 700 nm or more, 800 nm or more, 900 nm or more, 1200 nm or more, 1200 nm or more, 1300 nm or more or 1400 nm or more and 1500 nm or less, 1400 nm or less, 1300 nm or less, 1200 nm or less, 1100 nm or less, 1000 nm or less, 900 nm or less and 800 nm or less , 700 nm or less, 600 nm or less, 500 nm or less, 400 nm or less, 300 nm or less, or 200 nm or less. For example, the average particle size of the amphiphilic anisotropic powder may be about 270 nm.

The particle size of the amphiphilic anisotropic powder herein is the maximum length measured as the longest length of the powder particle. The particle size range of the amphiphilic anisotropic powder herein means that at least 95% of the amphipathic anisotropic powder present in the composition falls within this range.

In one embodiment of the present invention, the amphiphilic anisotropic powder may be prepared by polymerizing a first monomer to prepare a core of a first polymer spoloid, coating the core of the first polymer spoloid to form a core- And preparing an amphiphilic anisotropic powder in which the second polymer spolide is formed by reacting the first polymer spolide of the core-shell structure with the first monomer.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic view showing the principle of formation of an amphiphilic anisotropic powder according to an embodiment of the present invention. FIG. The core of the first polymer spolide may be formed through the shell of the first polymer spolide and may be grown to form a second polymer spoloid by the above manufacturing method.

In one embodiment, the amphiphilic anisotropic powder is prepared by (1) stirring the first monomer and the polymerization initiator to prepare a core of the first polymer spolide; (2) stirring the prepared core of the first polymer spolide with a monomer containing a first monomer, a polymerization initiator and a functional group to prepare a first polymer spolide having a coated core-shell structure; (3) preparing an amphiphilic anisotropic powder in which the second polymer spolide is formed by stirring the first polymer spoloid of the prepared core-shell structure with the second monomer and the polymerization initiator.

In the above steps (1), (2) and (3), stirring may be rotary stirring. It is preferable to rotate and stir because chemical mechanical modification and homogeneous mechanical mixing are required for producing uniform particles. The rotational stirring may be performed in a cylindrical rotating reactor, but the rotational stirring method is not limited thereto.

At this time, the design inside the reactor has a great influence on powder formation. The size and location of the baffles in the cylindrical rotating reactor and the degree of spacing between the impeller and the baffles greatly influence the uniformity of the particles produced. It is desirable to minimize the interval between the blades of the inner wing and the impeller to equalize the convection flow and the strength thereof, and to feed the powder reaction liquid below the wing length and to maintain the impeller rotation speed at a high speed. 200 rpm, and the length to diameter ratio of the reactor may be 1 to 3: 1 to 5, more specifically 10 to 30 cm in diameter and 10 to 50 cm in height. The reactor size can be varied in proportion to the reaction capacity. The material of the cylindrical rotating reactor may be ceramics, glass, etc., and the temperature at the time of stirring is preferably 50 to 90 ° C.

In the cylindrical rotating reactor, the simple rotation method is capable of producing uniform particles, and is a low energy method requiring less energy and maximizing the reaction efficiency, enabling mass production. The conventional tumbling method in which the reactor itself rotates requires high energy and restricts the size of the reactor since the entire reactor must be tilted at a constant angle and rotated at high speed. The amount produced due to reactor size limitations was also limited to small quantities of the order of several hundreds of milligrams to several grams, making them unsuitable for mass production.

In one embodiment, the first monomer and the second monomer may be the same or different, and may be specifically vinyl monomers. The first monomer added in the step (2) is the same as the first monomer used in the step (1), and the polymerization initiator used in each step may be the same or different.

In one example, the vinyl monomer may be vinyl aromatic. In one example, the vinyl monomer may be substituted or unsubstituted styrene.

In one example, the polymerization initiator may be a radical polymerization initiator, specifically, a peroxide type, an azo type, or a mixture thereof. Ammonium persulfate, sodium persulfate and potassium persulfate may also be used.

In one example, in the step (1), the first monomer and the polymerization initiator may be mixed at a weight ratio of 100 to 1000: 1. In another aspect, the first monomer and the polymerization initiator may be mixed in a weight ratio of 100 to 750: 1, or 100 to 500: 1, or 100 to 250: 1.

In another aspect, a stabilizer may be added together with the first monomer and the polymerization initiator in the step (1) to mix the first monomer, the polymerization initiator, and the stabilizer in a weight ratio of 100 to 1000: 1: 0.001 to 5. The powder size and shape are determined according to the first polymer spoil size adjustment in the initial stage (1), and the first polymer spoil size can be adjusted according to the weight ratio of the first monomer, the polymerization initiator, and the stabilizer. Further, by mixing at the weight ratio within the above range, the shape and uniformity of the anisotropic powder can be remarkably increased.

In one example, the stabilizer may be an ionic vinyl monomer, and specifically sodium 4-vinylbenzene sulfonate may be used. Stabilizers prevent swelling of the resulting particles and provide positive or negative charge on the powder surface to electrostatically prevent interactions (bonds) during grain formation.

The weight ratio of the first monomer, the polymerization initiator and the stabilizer is 80 to 135: 1: 1 to 5, specifically 95 to 120: 1: 2 to 4, when the amphiphilic anisotropic powder has a size of 200 to 250 nm. 1 < / RTI > polymer spolide.

When the amphiphilic anisotropic powder has a size of 400 to 450 nm, the weight ratio of the first monomer, the polymerization initiator and the stabilizer is in the range of 225 to 240: 1: 1 to 3, specifically 230 to 235: 1: 1 to 3 , ≪ / RTI > the first polymeric spheroids.

When the amphiphilic anisotropic powder has a size of 1100 to 2500 nm, the first polymer having a weight ratio of the first monomer, the polymerization initiator and the stabilizer is 110 to 130: 1: 0, specifically 115 to 125: 1: 0 ≪ / RTI >

The amphiphilic anisotropic powder having an asymmetric snowman shape is preferably an amorphous powder having a weight ratio of the first monomer, the polymerization initiator and the stabilizer of 100 to 140: 1: 8 to 12, specifically 110 to 130: 1: 9 to 11 Can be prepared from polymeric sphereoids.

The amphiphilic anisotropic powder having an asymmetric reverse snowman shape is preferably an amphipathic powder having a weight ratio of the first monomer, the polymerization initiator and the stabilizer of 100 to 140: 1: 1 to 5, specifically 110 to 130: 1: 2 to 4 1 < / RTI > polymer spolide.

In one embodiment, the monomer containing a functional group in the step (2) may be a siloxane-containing (meth) acrylate. Specific examples thereof include 3- (trimethoxysilyl) propyl acrylate, 3- (trimethoxysilyl) Methacrylate, vinyltriethoxysilane, vinyltrimethoxysilane, or a mixture thereof.

In one embodiment, the monomer containing the first monomer, the polymerization initiator and the functional group in the step (2) may be mixed in a weight ratio of 30 to 100: 0.2 to 1.0: 1 to 20. In another aspect, the monomer containing the first monomer, the polymerization initiator and the functional group may be mixed at a weight ratio of 150 to 300: 1: 6 to 40. The degree of coating can be controlled according to the weight ratio, and the shape of the amphipathic anisotropic powder is determined according to the degree of coating, and when the weight ratio is adjusted, the coating thickness is increased to about 10 to 30%, specifically about 20% And the coating is too thick, so that the pulverization does not proceed or the pulverization is proceeded well without the problem that the pulverization is too thin. In addition, by mixing at the weight ratio within the above range, there is an effect that the uniformity of the anisotropic powder can be increased.

According to the above step (3), a part of the core of the first polymer spolide is protruded from the one side of the first polymer spolide of the core-shell structure through the shell and the protrusions are grown by the polymer of the second monomer, Can be formed.

For example, in the step (3), the second monomer and the polymerization initiator may be mixed in a weight ratio of 150 to 250: 1. In another aspect, the second monomer and the polymerization initiator may be present in an amount of from 160 to 250: 1, or from 170 to 250: 1, or from 180 to 250: 1, or from 190 to 250: 1, or from 200 to 250: : 1, or 220 to 250: 1, or 230 to 250: 1, or 240 to 250: 1.

In another aspect, the second monomer, the polymerization initiator and the stabilizer may be mixed in a weight ratio of 150: 250: 1: 0.001 to 5 by adding the second monomer and the polymerization initiator together with the stabilizer in the step (3). Specific types of stabilizers are as described above. By mixing at a weight ratio within the above range, uniformity of the anisotropic powder can be enhanced.

In one embodiment, in the step (3), the second monomer content may be 40 to 300 parts by weight when the weight of the first polymer spoil of the core-shell structure is 100 parts by weight. Specifically, when the second monomer content is 40 to 100 parts by weight when the first polymer spoil weight of the core-shell structure is 100 parts by weight, the asymmetric snowman type powder is obtained, and 100 to 150 parts by weight, or 110 to 150 parts by weight, When the weight is in the range of 150 to 300 parts by weight or in the range of 160 to 300 parts by weight, an asymmetric reverse snowman type powder is obtained. In addition, by mixing at the weight ratio within the above range, there is an effect that the uniformity of the anisotropic powder can be increased.

In another embodiment of the present invention, in the production of an amphiphilic anisotropic powder according to an embodiment of the present invention, the step (3) may further include the step of (4) introducing a hydrophilic functional group into the produced anisotropic powder have.

In one embodiment, the hydrophilic functional group in step (4) is not limited thereto, but may be introduced using a silane coupling agent and a reaction control agent.

In one embodiment, the silane coupling agent is selected from the group consisting of (3-aminopropyl) trimethoxysilane, N- [3- (trimethoxysilyl) propyl] ethylenediamine, N- [3- (trimethoxysilyl) (Trimethoxysilyl) propyl] urea and 3 - [(trimethoxysilyl) propyloxy] -1,2 (trimethylsilyl) Propanediol, and specifically may be at least one selected from the group consisting of N- [3- (trimethoxysilyl) propyl] ethylenediamine.

For example, the silane coupling agent may be added in an amount of 35 to 65 parts by weight, for example, 40 to 60 parts by weight based on 100 parts by weight of the anisotropic powder prepared in the step (3). Within this range, hydrophilization can be appropriately performed.

In one example, the reaction modifier may be ammonium hydroxide.

For example, the reaction modifier may be added in an amount of 85 to 115 parts by weight, for example, 90 to 110 parts by weight based on 100 parts by weight of the anisotropic powder prepared in the step (3). Within this range, hydrophilization can be appropriately performed.

In another embodiment of the present invention, in the production of the amphiphilic anisotropic powder according to one embodiment of the present invention, the step (3) is followed by (4) a step of introducing a sugar-containing functional group into the produced anisotropic powder .

In the step (4), the functional group containing sugar is not limited thereto, but may be introduced using a sugar-containing silane coupling agent and a reaction control agent.

According to one exemplary embodiment, the sugar-containing silane coupling agent is selected from the group consisting of N- {N- (3-triethoxysilylpropyl) aminoethyl} gluconamide, N- (3-triethoxysilylpropyl) And N- {N- (3-triethoxysilylpropyl) aminoethyl} -oligo-hyaluronamide.

According to one exemplary embodiment, the reaction modifier may be ammonium hydroxide.

For example, the reaction modifier may be added in an amount of 85 to 115 parts by weight, for example, 90 to 110 parts by weight based on 100 parts by weight of the anisotropic powder prepared in the step (3). The introduction of a sugar-containing functional group within the above range can be suitably performed.

The preparation of the amphiphilic anisotropic powder according to the above method does not use a cross-linking agent, so there is no production entanglement. Thus, the yield is high and uniform, and mass production is easier than the tumbling method using a simple agitation method. In particular, there is an advantage that a nano size of 300 nm or less can be mass-produced in a unit of tens g to several tens of kg.

In one embodiment, the size of the emulsified particles may be from 1 μm to 100 μm in average particle size, for example from 10 μm to 30 μm. Specifically, it is preferable that the average particle diameter is 1 占 퐉 or more, 2 占 퐉 or more, 3 占 퐉 or more, 4 占 퐉 or more, 5 占 퐉 or more, 6 占 퐉 or more, 7 占 퐉 or more, 8 占 퐉 or more, At least 15 탆, at least 16 탆, at least 17 탆, at least 18 탆, at least 19 탆, at least 20 탆, at least 21 탆, at least 22 탆, at least 23 탆, at least 24 탆 At least 25 탆, at least 26 탆, at least 27 탆, at least 28 탆, at least 29 탆, at least 30 탆, at least 35 탆, at least 40 탆, at least 45 탆, at least 50 탆, at least 55 탆, The average particle diameter may be 100 占 퐉 or less, 95 占 퐉 or less, 90 占 퐉 or less, 85 占 퐉 or less, 80 占 퐉 or less, 45 μm or less, 40 μm or less, 35 μm or less, 30 μm or less, 29 μm or less, 28 μm or less, or less than or equal to 30 μm, less than or equal to 75 μm, less than or equal to 70 μm, less than or equal to 65 μm, 27 탆 or less, 26 탆 or less, 25 탆 Not more than 24 μm, not more than 23 μm, not more than 22 μm, not more than 21 μm, not more than 20 μm, not more than 19 μm, not more than 18 μm, not more than 17 μm, not more than 16 μm, not more than 15 μm, not more than 14 μm, Or less, 11 μm or less, 10 μm or less, 9 μm or less, 8 μm or less, 7 μm or less, 6 μm or less, 5 μm or less, 4 μm or less, 3 μm or less and 2 μm or less.

In the present specification, the average particle diameter of the emulsified particles means an average value of the diameter of a single particle. In the state of the large emulsion particle, the particle diameter of the emulsion particle is not uniform, and the emulsion particle having a particle diameter in the wide range of 0.1 to 2000 μm coexists. The mean particle diameter of the macro emulsion particles may be, for example, 20 mu m.

In one example, the composition may comprise the amphiphilic anisotropic powder in an amount of 0.01 to 10% by weight, preferably 0.1 to 1% by weight, based on the total weight of the composition. More specifically, it is preferable that the content of the inorganic filler is 0.01 wt% or more, 0.1 wt% or more, 0.2 wt% or more, 0.3 wt% or more, 0.4 wt% or more, 0.5 wt% or more, 0.6 wt% or more, 0.7 wt% or more, 0.8 wt% %, Up to 9 wt.%, Up to 8 wt.%, Up to 7 wt.%, Up to 6 wt.%, Up to 5 wt.%, Up to 4 wt.%, Or up to 3 wt.%, Or less, 2 wt% or less, or 1 wt% or less. For example, the composition may comprise the amphiphilic anisotropic powder in an amount of 0.1% to 20% by weight, for example, 0.1% to 1%, and in one embodiment 0.5% by weight based on the total weight of the composition . Stable emulsion particles can be formed within the above range, and emulsion particles having an appropriate size can be formed.

In one aspect, the ratio of the substance having the positive potential to the substance having the negative potential: amphiphilic anisotropic powder: can be included in a weight ratio of 100: 1 to 20: 1-10. Specifically, the weight ratio is 100: 1.5-18: 1.2-9, 100: 2-16: 1.4-8, 100: 2.5-14: 1.6-7, 100: 3-12: 1.8-6, 100: 3.5 -10: 2-5, 100: 4-8: 2.2-4, or 100: 4.5-6: 2.4-4 and the weight ratio is 100: 1.5-20: 1-9, 100: 20: 1-8, 100: 2.5-20: 1-7, 100: 3-20: 1-7, 100: 3.5-20: 1-6, 100: 4-20: 1-5, or 100: 4.5 -20: 1-4, and the weight ratio is 100: 1-18: 2-10, 100: 1-16: 3-10, 100: 1-14: 4-10, 100: 1-12 : 5-10, 100: 1-10: 6-10, 100: 1-8: 7-10.

In one aspect, the emulsifying composition may comprise a pH adjusting agent.

In one aspect, the water phase of the emulsified composition may further comprise an acid.

Specifically, the acid may be included in any acid used in cosmetics. For example, the acid may be one or more selected from the group consisting of lactic acid, glycolic acid, ethyl ascorbic acid, ascorbic acid, and glutamic acid. But is not limited thereto.

In one aspect of the present invention, the viscosity of the composition may be 100-100,000 cps, for example, the viscosity of the composition may be 2,000-15,000 cps. Since the composition according to this embodiment does not require stabilization through an incremental increase, it is possible to provide a composition having a wide range of viscosity regardless of viscosity.

The viscosity of the composition can be measured using a BROOKFIELD Viscometer.

In one embodiment, the viscosity of the composition may be controlled by the content of a substance having a positive potential or the content of a substance having a negative potential, for example the composition may have a viscosity of at least 15000 cps.

For example, the composition may have a viscosity of, for example, greater than 200 cps, greater than 300 cps, greater than 400 cps, greater than 500 cps, greater than 600 cps, greater than 700 cps, greater than 800 cps, greater than 900 cps, greater than 1000 cps, At least 1200 cps, at least 1300 cps, at least 1400 cps, at least 1500 cps, at least 1600 cps, at least 1700 cps, at least 1800 cps, at least 1900 cps, at least 2000 cps, at least 2100 cps, at least 2200 cps, at least 2300 cps, More than 2400 cps, greater than 2500 cps, greater than 2600 cps, greater than 2700 cps, greater than 2800 cps, greater than 2900 cps, greater than 3000 cps, greater than 3100 cps, greater than 3200 cps, greater than 3300 cps, greater than 3400 cps, greater than 3500 cps More than 3700 cps, greater than 3800 cps, greater than 3900 cps, greater than 4000 cps, greater than 4100 cps, greater than 4200 cps, greater than 4300 cps, greater than 4400 cps, greater than 4500 cps, greater than 4600 cps, greater than 4700 cps, greater than 4800 cps, More than 4900 cps, more than 5000 cps, more than 5100 cps, more than 5200 cps, more than 5300 cps, more than 5400 cps, more than 5500 cps, more than 6000 cps, 7000 cps More than 8000 cps, more than 9000 cps, more than 10,000 cps, more than 11000 cps, more than 12000 cps, more than 13000 cps, more than 14000 cps, more than 15000 cps, more than 16000 cps, more than 17000 cps, more than 20000 cps, more than 30000 cps cpm or more, 50000 cps or more, 60000 cps or more, 70000 cps or more, 80000 cps or more, 90000 cps or 100000 cps or less, 100000 cps or less, 90000 cps or less, 80000 cps or less, 70000 cps or less, No more than 10,000 cps, no more than 10,000 cps, no more than 10,000 cps, no more than 10,000 cps, no more than 50000 cps, no more than 40,000 cps, no more than 30000 cps, no more than 20,000 cps, no more than 17,000 cps, no more than 16,000 cps, no more than 15,000 cps, no more than 14,000 cps, Less than 8000 cps, less than 7000 cps, less than 6000 cps, less than 5000 cps, less than 4900 cps, less than 4800 cps, less than 4700 cps, less than 4600 cps, less than 4500 cps, less than 4400 cps, less than 4300 cps, less than 4200 cps, 4100 cps or less, 4000 cps or less, 3900 cps or less, 3800 cps or less, 3700 cps or less, 3600 cps or less, 3500 cps or less, 3400 cps or less, 3300 cps or less, 3200 cps or less, 3100 cps or less, 3000 cps or less, 2900 cps or less, 2800 cps or less, 2700 cps or less, 2600 cps or less, 2500 cps or less, 2400 cps or less, 2300 cps or less Less than 2200 cps, less than 2100 cps, less than 2000 cps, less than 1900 cps, less than 1800 cps, less than 1700 cps, less than 1600 cps, less than 1500 cps, less than 1400 cps, less than 1300 cps, less than 1200 cps, less than 1100 cps cps or less, 900 cps or less, 800 cps or less, 700 cps or less, 600 cps or less, 500 cps or less, 400 cps or less, 300 cps or less, or 200 cps or less. The composition may have excellent emulsion stability at a viscosity of 100-100,000 cps, and in particular, the composition may have a low viscosity at a low viscosity of 2000-15000 cps, for example at a low viscosity of 3000-10000 cps.

In one embodiment, the composition may further comprise a surfactant for emulsification. Examples of the surfactant include lauryl PEG-9 polydimethylsiloxyethyl dimethicone, cyclopentasiloxane * PEG-10, and the like. Examples of the surfactant include, but are not limited to, Dimethicone * Distearimonium Hectorite, Cetyl PEG.PPG-10/1 Dimethicone (Cetyl Dimethicone Copolyol; Cetyl PEG.PPG-10/1 Dimethicone (Cetyl Dimethicone * Copolyol, etc.), arachidyl alcohol / behenyl alcohol / arachidyl glucoside (ARACHIDYL ALCOHOL / BEHENYL ALCOHOL / ARACHIDYL GLUCOSIDE), cetearyl alcohol * CETEARYL ALCOHOL * CETEARYL GLUCOSIDE), C14-22 alcohol * C12-20 alkyl glucoside (C14-22 ALCOHOLS * C12-20 ALKYL GLUCOSIDE), glyceryl stearate * PEG-100 stearate (Glyceryl Stearate * PEG- W You The like of a surfactant used, but is not limited thereto. The surfactant may be included in an amount of 0 to 20% by weight, 0 to 10% by weight, or 0 to 5% by weight based on the total weight of the composition. In this embodiment, it is possible to stabilize the emulsified formulation while containing a small amount of surfactant.

The composition according to embodiments of the present invention may be a cosmetic composition. The cosmetic composition may be formulated containing a cosmetically or dermatologically acceptable medium or base. It may be in the form of a suspension, a microemulsion, a microcapsule, a microgranule or an ionic (liposome) and a non-ionic follicular dispersion, or a cream, a skin, a lotion, a powder, an ointment, a spray, May be provided in the form of a stick. It can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions may be prepared according to conventional methods in the art.

In addition, the cosmetic composition according to embodiments of the present invention may be in the form of powders, fatty substances, organic solvents, solubilizers, thickeners, gelling agents, softeners, antioxidants, suspending agents, stabilizers, foaming agents, , Water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, barrier agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics And any other ingredients used, such as cosmetics or adjuvants commonly used in the field of dermatology. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields. The cosmetic composition according to the embodiments of the present invention may further contain a skin absorption promoting substance to increase the skin improving effect.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are merely illustrative of the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

Production Examples 1-1 to 1-4 were prepared according to the composition shown in Table 1 below. Specific methods are described below.

The components used in the following Production Examples are as follows.

PS (1L shaking reaction tank)		CS		DB
Water	300	PS	300	CS	240
MeOH	40	Water	250	Water	350
Styrene	50	TMSPA	6	AIBN	0.2
KPS	0.5	Styrene	50	Styrene	40
SVBS	1.0	AIBN	0.2	SVBS	0.35

MeOH: Methanol cosolvent KPS: Potassium persulfate (initiator)

SVBS: Sodium vinyl benzene sulfonate (stabilizer)

PS: Polystyrene (polymer bead)

CS: Coated first polymeric spheroid with core-shell structure

DB: Amphipathic anisotropic powder

TMSPA: Trimethoxysilyl propylacrylate (functional group)

AIBN: Azobisisobutyronitrile (polymerization initiator)

[Preparation Example 1] Preparation of an amphipathic anisotropic powder

Production Example 1-1. Manufacture of Polystyrene (PS) First Polymer Spheroid

50 g of styrene as a monomer, 1.0 g of sodium 4-vinylbenzenesulfonate as a stabilizer and 0.5 g of azobisisobutyronitrile (AIBN) as a polymerization initiator were mixed in a water bath at 75 DEG C For 8 hours. The reaction was stirred in a cylindrical rotating reactor. The cylindrical rotating reactor was 11 cm in diameter, 17 cm in height, made of glass, and rotated at a speed of 200 rpm.

Production Example 1-2. Preparation of Coated First Polymer Spheroid with Core-Shell (CS) Structure

(Styrene), 6 g of TMSPA (3- (trimethoxysilyl) propylacrylate) as a monomer, and 0.2 g of azobisisobutyronitrile (AIBN) as a polymerization initiator were added to 300 g of the obtained first polymeric spolide of polystyrene ) Were mixed and reacted at 75 DEG C for 8 hours. The reaction was stirred in a cylindrical rotating reactor.

Production Example 1-3. Production of amphiphilic anisotropic powder (DB)

40 g of styrene as a monomer, 0.35 g of sodium 4-vinylbenzenesulfonate as a stabilizer, and 0.35 g of azobisisobutyronitrile as a polymerization initiator were added to 240 g of the polystyrene core shell (PS-CS) water dispersion solution obtained as a result of the reaction, And 0.2 g of azobisisobutyronitrile (AIBN) were mixed and heated at 75 캜 for 8 hours. The reaction was stirred in a cylindrical rotating reactor to produce an amphiphilic anisotropic powder having an average particle size of 235 탆.

Production Example 1-4. Preparation of Hydrophilic Amphiphilic Anisotropic Powder

30 g of N- [3- (trimethoxysilyl) propyl] ethylenediamine as a silane coupling agent and 30 g of N- [3- (trimethoxysilyl) propyl] ethylenediamine were added to 600 g of the aqueous dispersion solution of the obtained anisotropic powder, (Ammmonium hydroxide) were mixed and reacted at 25 DEG C for 24 hours to introduce a hydrophilic functional group. The reaction was stirred in a cylindrical rotating reactor to prepare a hydrophilized amphipathic anisotropic powder.

[Experimental Example 1] Confirmation of emollient change according to aqueous pH

The emulsion composition of the present invention was examined for changes in the physical properties of a substance having a positive potential (emollient) depending on the pH of the aqueous phase, and the effect of the type of acid affecting the pH was examined.

The substance having a positive potential (Emollient) was purchased from Nippon Emulsion Co., Ltd., and HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE, which is a trade name AMITER MA-HD, was used, Lithospermi Radix ) extract And hexyldecyl myristoyl methylaminopropionate were used. Water, glycolic acid, and ethyl ascorbic acid were used as the water phase. Extracts of B. pertussis were used as a reddish oil-soluble material to facilitate visual confirmation of film formation and emulsification. There is no influence on the formation of the formulations even when the pigment is changed to another oil-soluble dye. When the layer separation occurs, the red layer is identified with a bright red color, and when the emulsification occurs, it appears to be light pink.

In the experiment, each raw material of acid was put into the water as shown in Table 2, prepared by titrating to the corresponding pH, and the oil phase and the water phase were hand-mixed.

ingredient	Reference Example 1	Reference Example 2	Reference Example 3	Reference Example 4
HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE	10	10	30	30
Acanthopteran extract	One	One	One	One
water	to 100	to 100	to 100	to 100
Glycolic acid	0	pH 3 titration	0	0
Ethyl ascorbic acid	0	0	0	pH 4 titration
phenomenon	Layer separation	oil paint	Layer separation	oil paint

The results can be confirmed with reference to Fig. Specifically, when only a substance having water and a positive potential exists, the layer separation is performed by the behavior of a substance having a general positive potential (Referential Examples 1 and 3, (1) and (3) in FIG. 2) It was confirmed that the tertiary amine moiety of the substance having a positive electric potential has a positive electric potential through the base reaction and serves as a surfactant (Reference Examples 2 and 4, (2) and (4) in FIG. 2). Further, it was confirmed that there was no influence depending on the type of acid.

[Experimental Example 2] Determination of thin film formation of a thickener and a substance having a positive electric potential according to pH

In order to confirm the difference in the degree of formation of the thin film layer of the substance having positive electric potential and the substance having negative electric potential according to pH in the emulsion of the present invention.

0.1 wt% of carbomer as a substance having a negative potential was added to the aqueous phase. As shown in Table 3, tromethamine was neutralized with neutralizing agent to pH 3, 4, 5, and 6 in each reference example. After neutralization, hexyldecyl myristoyl methyl aminopropionate was slowly poured without mixing to observe the thin film layer on the surface.

Component (% by weight)	Reference Example 5	Reference Example 6	Reference Example 7	Reference Example 8
HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE	10	10	10	10
water	to 100	to 100	to 100	to 100
Carbomer	0.1	0.1	0.1	0.1
Tromethamine	Verify the target pH reached by titrating pH
pH	3	4	5	6
phenomenon	White film formation	White film formation	Semi-transparent film formation	Transparent film formation

The result can be confirmed with reference to FIG. Specifically, even if a substance having the same positive potential is used, the positive potential of the substance having a positive potential differs depending on the pH level. Positive potentials of counter-positively charged positive potentials, which can bind to carbomers with negative potential, increase with decreasing pH, and thus the difference in the degree of formation of the thin film layer due to charge interactions . It was confirmed that a transparent thin film was formed at pH 6 (Reference Example 8), from which it is expected that the thin film layer becomes unstable in a formulation of pH 7 or more.

[Experimental Example 3] Comparison of emulsifying ability according to the presence or absence of dislocation in the upper part

The emulsifying powers of amphiphilic anisotropic powders of hexyldecyl myristoyl methyl aminopropionate having a dislocationless general oil and positive potential were compared.

As the oil phase, Comparative Example 1 was prepared by mixing a squalane extract with a common oil having no dislocation. In Example 1, emulsion helixdecyl myristoyl methyl aminopropionate having a positive potential varying with pH, The extracts were mixed and prepared.

Water containing the amphiphilic anisotropic powder prepared in Preparation Example 1-3 was prepared as an aqueous phase, and the aqueous phase was pH 5 without any pH adjustment. The oil phase was added to the liquid phase (pH 5) of the amphiphilic anisotropic powder without pH adjustment of the water phase and observed by hand mixing. A photograph of the composition is shown in FIG.

ingredient	Reference Example 9	Reference Example 10
HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE	10	-
Squalane	-	10
Acanthopteran extract	One	One
water	To 100	To 100
The amphiphilic anisotropic powder (Preparation Example 1-3)	0.5	0.5
pH	6	6
Formation of emulsified layer through oil and powder bonding	formation	Exist as an oil layer without formation

The results can be confirmed with reference to FIG. Specifically, in Reference Example 10 (left side) including squalane, the emulsion layer was not formed but remained as an oil layer, whereas in Reference Example 9 (right side) containing hexyldecyl myristoyl methylaminopropionate, Is observed to be excellent. This is because the amphiphilic anisotropic powder having a negative electric potential is combined with a substance having a positive electric potential to enhance the emulsifying power.

[Experimental Example 4] Bond formation of an amphipathic anisotropic powder and a substance having a positive potential

The Z-potential of the amphiphilic anisotropic powder and the change in the numerical value after the binding of the amphiphilic anisotropic powder and hexyldecyl myristoyl methyl aminopropionate are shown in FIG. Specifically, the composition containing the amphiphilic anisotropic powder in the composition of Table 5 and the composition containing the amphiphilic anisotropic powder and hexyldecyl myristoyl methylaminopropionate were measured for Z-potential using a Zetasizer (Malvern) Respectively.

ingredient	Reference Example 11 (lower graph)	Reference Example 12 (upper graph)
HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE	20	0
water	To 100	To 100
The amphiphilic anisotropic powder (Preparation Example 1-3)	0.5	0.5
pH	6	6

Figure 5 shows that the (-) z-potential value of the amphiphilic anisotropic powder itself (upper graph) is lower than that of the amphiphilic anisotropic powder in the (+) direction while the amphiphilic anisotropic powder and hexyldecyl myristoyl methylaminopropionate bind in the lower graph. Which indicates the binding of the amphiphilic anisotropic powder to the emollient.

[Experimental Example 5] Confirmation of stability of pilot scale formulation

In the emulsified composition of the present invention, a formulation using only carbomer and hexyldecyl myristoyl methyl aminopropionate and a particle varying with an amphipathic anisotropic powder are compared and observed.

The viscosity of the emulsion composition prepared in the contents of Table 6 was measured at 30 ° C on the next day of manufacture using a viscosity meter (BROOKFIELD Viscometer, SPINDLE # 3, 12RPM, 30 ° C, the next day).

ingredient	Example 1	Comparative Example 1	Comparative Example 2
HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE	5	5	0
Squalane	5	5	10
water	To 100	To 100	To 100
트롬 메민	0.14	0.14	0.14
The amphiphilic anisotropic powder (Preparation Example 1-3	0.5	-	-
Carbomer	0.2	0.2	0.2
pH	6	6	6
Initial viscosity	4000	4500	5000
4-week time stability	maintain	maintain	degradation
Emulsion particle size	An average of 20 占 퐉 (10 to 30 占 퐉)	1 to 10 μm	1 to 10 μm
surface	Good	Good	Oil band on surface

7A, 7B, and 7C are photographs of micrographs of emulsion particles observed after the compositions of Comparative Example 1, Example 1, and Comparative Example 2 were stored at 30 DEG C for 4 weeks, respectively. The emulsion formulations of Comparative Example 1 ) And the amphiphilic anisotropic powder of Example 1 (Fig. 7B) were the same formulation except that Example 1 contained 0.5 wt% of the amphiphilic anisotropic powder, and Comparative Example 2 (Fig. 7C) Powder, and positive displacement material.

In Example 1, it was confirmed that the amphiphilic anisotropic powder is located at a site where the film is formed by the interaction between charges, and the particles are made large.

In addition, Comparative Example 2 (Fig. 7C) did not achieve 4-week stability in the pilot scale, but Example 1 (Fig. 7B) in which amphipathic anisotropic powder was combined had 4000 cps and formed large particles, And it was confirmed that it has stability.

Claims (20)

1. A substance having a positive potential;

   A material having a negative potential; And

   An emulsifying composition comprising a hydrophilic one-sided and a hydrophobic two-sphere type polymeric amphiphilic anisotropic powder,

   Wherein the powder has a structure in which the hydrophobic part partially penetrates into the inside of the hydrophilic one to form a hydrophilic one of the cores, the hydrophilic one shell comprises a functional group,

   Wherein the emulsion composition comprises two phases, the phases having opposite potentials.
2. The method according to claim 1,

   Wherein the emulsion composition is an aqueous or oil-in-water emulsion composition.
3. The method according to claim 1,

   Wherein the dual spheroidal polymeric amphiphilic anisotropic powder is present at the interfaces of the two phases.
4. The method according to claim 1,

   Wherein the substance having a positive potential comprises at least one selected from an aliphatic amine compound, an aromatic amine compound and an amine group-containing silicone compound.
5. The method according to claim 1,

   The substance having a positive potential is selected from the group consisting of hexyldecyl myristoyl methylaminopropionate, bis amodimethicone, amodimethicone, and aminopropyl dimethicone. Wherein the emulsifying composition comprises at least one selected from the group consisting of water,
6. The method according to claim 1,

   Wherein the composition comprises from 0.01% to 75% by weight of the substance having the positive potential relative to the total weight of the composition.
7. The method according to claim 1,

   Wherein the substance having a negative electric potential comprises at least one member selected from an acrylic acid-based polymer compound, a polysaccharide polymer compound and a sulfonic acid-based polymer compound.
8. The method according to claim 1,

   The substance having a negative electric potential is selected from the group consisting of polyacrylic acid, polymethacrylic acid, polymethylmethacrylic acid, methylmethacrylate-acrylic acid copolymer, vinylpyrrolidone-acrylic acid copolymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate (ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER), carbomer, alginic acid, pectin, polygalacturonic acid, polyacrylic acid, polyacrylic acid, Polystyrene sulfonic acid, and polystyrene sulfonic acid.
9. The method according to claim 1,

   Wherein the composition comprises from 0.01% to 10% by weight, based on the total weight of the composition, of the substance having the negative potential.
10. The method according to claim 1,

    Wherein the emulsion composition has a pH of 7 or less.
11. The method according to claim 1,

    Wherein the functional group is a siloxane.
12. The method according to claim 1,

    The hydrophilic one side of the powder is a core-shell structure,

    Wherein the hydrophilic one of the cores and the hydrophobic one include a vinyl aromatic polymer,

    The hydrophilic one-side shell comprises a vinyl aromatic monomer; And a monomer containing a functional group.
13. 13. The method of claim 12,

    Wherein the functional group-containing monomer is a siloxane-containing (meth) acrylate.
14. The method according to claim 1,

    Wherein the amphiphilic anisotropic powder has a particle size of 100 to 1500 nm.
15. The method according to claim 1,

    Wherein the amphiphilic anisotropic powder comprises 0.01 to 10% by weight based on the total weight of the composition.
16. The method according to claim 1,

    Wherein the ratio of the material having the positive electric potential: the material having the amphiphilic anisotropic powder: the negative electric potential is contained in a weight ratio of 100: 1 to 20: 1-10.
17. The method according to claim 1,

    Wherein the aqueous phase of the emulsified composition further comprises an acid.
18. 18. The method of claim 17,

    Wherein the acid is at least one selected from the group consisting of lactic acid, glycolic acid, ethyl ascorbic acid, ascorbic acid, and glutamic acid, Composition.
19. The method according to claim 1,

    Wherein the substance having the positive potential interacts with the substance having the negative potential to form a film.
20. The method according to claim 1,

    Wherein the composition has a viscosity of 100-100,000 cps.

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