WO2019104852A1 - Porous dental implant having surface inlaid with degradable layer and preparation method therefor - Google Patents

Porous dental implant having surface inlaid with degradable layer and preparation method therefor Download PDF

Info

Publication number
WO2019104852A1
WO2019104852A1 PCT/CN2018/073414 CN2018073414W WO2019104852A1 WO 2019104852 A1 WO2019104852 A1 WO 2019104852A1 CN 2018073414 W CN2018073414 W CN 2018073414W WO 2019104852 A1 WO2019104852 A1 WO 2019104852A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
pile
degradable layer
dental implant
spherical hole
Prior art date
Application number
PCT/CN2018/073414
Other languages
French (fr)
Chinese (zh)
Inventor
张春雨
季方秋
陈贤帅
王亚玲
颜瑜
冯科瀚
冯伟
Original Assignee
广州市健齿生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广州市健齿生物科技有限公司 filed Critical 广州市健齿生物科技有限公司
Publication of WO2019104852A1 publication Critical patent/WO2019104852A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Definitions

  • the invention relates to the field of implant technology.
  • the traditional dental implant is made of pure titanium or titanium alloy with solid structure. Its elastic modulus and yield strength are much larger than bone tissue, which is easy to cause stress shielding, which affects the regeneration of bone tissue, which is not conducive to osseointegration and ultimately affects planting. Body stability and service life.
  • the existing porous structure implants are manufactured by 3D printing, which is easily affected by the processing precision, and the stress concentration occurs at the pores, and finally the mechanical strength of the porous implant dental implants at the initial stage of planting is not up to standard.
  • the present invention designs a porous dental implant having a surface inlaid with a degradable layer material, which is filled with a degradable layer made of magnesium in the pores of the porous dental implant, so that the implant is solid at the beginning of planting. Structure to ensure that it has sufficient mechanical strength. After planting, the degradable layer will degrade itself, which will vacate the pores, induce bone tissue to grow in, and finally the implant will bone-engage with the alveolar bone.
  • a method for preparing a porous dental implant having a surface inlaid with a degradable layer comprises the following steps:
  • the implant-based pile is printed by pure titanium using SLM technology, and the surface thereof is provided with a spherical hole or a thread groove;
  • the metal magnesium particles having a melting point lower than that of pure titanium are placed in a spherical hole or a thread groove, and the magnesium particles are heated by laser irradiation to instantly increase the temperature to the melting point, so that the molten metal can be quickly attached to the spherical hole or the thread groove.
  • the dental implant can be obtained after the pile of the implant is cooled.
  • a porous dental implant having a surface inlaid with a degradable layer prepared by the above preparation method, comprising an implant-based pile having a porous structure, a spherical hole or a thread groove on the surface of the implant pile and the porous The structure is connected, and the degradable layer penetrates into the filled partial or all porous structure.
  • the degradable layer filling the spherical hole or the thread groove protrudes from the surface of the implant pile.
  • the porous dental implant with the surface inlaid with the degradable layer disclosed in the invention has a degradable layer embedded on the surface thereof, and the metal magnesium is melted by laser heating to adhere, and can well cover the rough surface of the pure titanium implant pile of the SLM printing. , to reduce the processing requirements of SLM printing; at the same time, the elastic modulus and yield strength of magnesium are close to the bone tissue, so that the porous dental implant does not have the problem of stress shielding in the initial stage of planting; and magnesium is biologically active, and magnesium ions can promote cells. Growing up helps speed up the process of osseointegration.
  • FIG. 1 is a schematic view of an implant pile of Embodiment 1;
  • FIG. 2 is a schematic structural view of a porous dental implant having a surface inlaid with a degradable layer of Example 1;
  • Figure 3 is a schematic view of the implant pile of the second embodiment
  • FIG. 4 is a schematic view showing the structure of a porous dental implant having a surface inlaid with a degradable layer of Example 2.
  • Embodiment 1 As shown in FIGS. 1 and 2, a porous dental implant having a surface inlaid with a degradable layer, the implant-based pile 1 is printed by using SLM technology using pure titanium, and the implant-based pile 1 has a porous structure. a spherical hole a2 is arranged on the surface thereof, and a spherical hole a2 on the surface of the implant pile 1 is connected with the porous structure, and the internal thread of the implant pile 1 and the hexagonal connecting groove are finished by mechanical processing.
  • the metal magnesium particles having a melting point lower than that of pure titanium are placed in the spherical hole a2, and the magnesium particles are heated by laser irradiation to instantly increase the temperature to the melting point, so that the molten metal can quickly adhere to the spherical hole a2 and infiltrate into the partial or total porous structure.
  • the degradable layer a3 is formed, and the degradable layer a3 filling the spherical hole a2 is cooled and protrudes from the surface of the implant pile 1.
  • Embodiment 2 As shown in Figs. 3 and 4, it differs from Embodiment 1 in that a spherical hole is replaced with a thread groove b2.
  • the degradable layer b3 which fills the thread groove b2 and protrudes can serve as a temporary thread to facilitate mounting and fixing.
  • SLM technology combines machining and laser processing to shorten the processing cycle of dental implants and ensure their integrity and structural strength. And this processing method can ignore the error of SLM processing and reduce the cost.
  • the inlaid degradable layer protrudes from the surface and is evenly distributed to ensure uniform stress on the implant and convenient operation, thereby ensuring the initial stability and structural strength of the implant.
  • the initial stability of planting is high and the biocompatibility is good.
  • Degradation of the degradable layer releases magnesium ions to promote the regeneration of bone cells.
  • the vacancy of the pores induces the growth of bone cells, which ultimately ensures the occurrence of osseointegration. Thereby improving the success rate of implant surgery.
  • the implant of the present invention has a wide range of applications.

Abstract

A porous dental implant having a surface inlaid with a degradable layer and a preparation method therefor, the preparation method comprising: (1) by means of selective laser melting (SLM) technology, using pure titanium to print an implant pile (1), a surface thereof being provided with a spherical hole (a2) or a threaded groove (b2); (2) finishing an internal thread and a hexagonal connecting groove of the implant pile (1) by means of mechanical machining; (3) placing metal magnesium particles having a melting point that is lower than that of pure titanium into the spherical hole (a2) or the threaded groove (b2), heating the magnesium particles by using laser irradiation such that the temperature thereof immediately increases to the melting point thus enabling the molten liquid to quickly adhere to the spherical hole (a2) or the threaded groove (b2) so as to form a degradable layer (a3), and obtaining a dental implant after the implant pile (1) is cooled. The degradable layer of the dental implant may cover a rough surface of the SLM printed pure titanium implant pile well, and reduce the processing requirements of SLM printing; in addition, the elastic modulus and yield strength of magnesium are close to that of bone tissue, thus preventing the problem of stress shielding; moreover, magnesium has biological activity, and magnesium ions may promote cell growth.

Description

一种表面镶嵌可降解层的多孔牙种植体及其制备方法  Porous dental implant with surface inlaid degradable layer and preparation method thereof 技术领域  Technical field
本发明涉及植牙技术领域。The invention relates to the field of implant technology.
背景技术Background technique
传统牙种植体为实心结构的纯钛或者钛合金材质，其弹性模量、屈服强度远大于骨组织，极易造成应力屏蔽的问题，进而影响骨组织的再生，不利于骨结合，最终影响种植体的稳定性以及使用寿命。现有多孔结构的种植体采用3D打印制造，其受加工精度的影响极易出现加工缺陷，在孔隙处出现应力集中的情况，最终导致多孔结构的牙种植体在种植初期的力学强度不达标。The traditional dental implant is made of pure titanium or titanium alloy with solid structure. Its elastic modulus and yield strength are much larger than bone tissue, which is easy to cause stress shielding, which affects the regeneration of bone tissue, which is not conducive to osseointegration and ultimately affects planting. Body stability and service life. The existing porous structure implants are manufactured by 3D printing, which is easily affected by the processing precision, and the stress concentration occurs at the pores, and finally the mechanical strength of the porous implant dental implants at the initial stage of planting is not up to standard.
发明内容Summary of the invention
针对以上缺点，本发明设计了一种表面镶嵌可降解层材料的多孔牙种植体，其通过在多孔牙种植体的孔隙中填充由镁制成的可降解层，使得种植体在种植初期是实心结构，保证其有足够的力学强度。在种植后，可降解层将自行降解，从而将空出孔隙，诱导骨组织长入，最终种植体与牙槽骨发生骨结合。In view of the above disadvantages, the present invention designs a porous dental implant having a surface inlaid with a degradable layer material, which is filled with a degradable layer made of magnesium in the pores of the porous dental implant, so that the implant is solid at the beginning of planting. Structure to ensure that it has sufficient mechanical strength. After planting, the degradable layer will degrade itself, which will vacate the pores, induce bone tissue to grow in, and finally the implant will bone-engage with the alveolar bone.
一种表面镶嵌可降解层的多孔牙种植体的制备方法，包括以下步骤：A method for preparing a porous dental implant having a surface inlaid with a degradable layer comprises the following steps:
（1）通过SLM技术使用纯钛打印出种植体基桩，其表面设有球形孔或螺纹槽；(1) The implant-based pile is printed by pure titanium using SLM technology, and the surface thereof is provided with a spherical hole or a thread groove;
（2）通过机械加工的方式对种植体基桩的内螺纹以及六边形连接槽进行精加工；(2) finishing the internal thread of the implant pile and the hexagonal joint groove by means of machining;
（3）将熔点低于纯钛的金属镁颗粒放入球形孔或螺纹槽中，采用激光照射加热镁颗粒使其温度瞬间提高到熔点，导致熔液可以迅速附着在球形孔或螺纹槽上形成可降解层，待种植体基桩冷却后即可得到牙种植体。(3) The metal magnesium particles having a melting point lower than that of pure titanium are placed in a spherical hole or a thread groove, and the magnesium particles are heated by laser irradiation to instantly increase the temperature to the melting point, so that the molten metal can be quickly attached to the spherical hole or the thread groove. Degradable layer, the dental implant can be obtained after the pile of the implant is cooled.
由上述制备方法制得的表面镶嵌可降解层的多孔牙种植体，包括种植体基桩，所述种植体基桩内具有多孔结构，种植体基桩表面的球形孔或螺纹槽与所述多孔结构连通，可降解层渗入填充局部或全部多孔结构。a porous dental implant having a surface inlaid with a degradable layer prepared by the above preparation method, comprising an implant-based pile having a porous structure, a spherical hole or a thread groove on the surface of the implant pile and the porous The structure is connected, and the degradable layer penetrates into the filled partial or all porous structure.
进一步，填充球形孔或螺纹槽的可降解层突出于种植体基桩表面。Further, the degradable layer filling the spherical hole or the thread groove protrudes from the surface of the implant pile.
本发明公开的表面镶嵌可降解层的多孔牙种植体，其表面镶嵌的可降解层是金属镁通过激光加热熔化而实现附着，能够很好地掩盖SLM打印的纯钛种植体基桩的粗糙表面，降低SLM打印的加工要求；同时镁的弹性模量、屈服强度接近骨组织，从而使得多孔牙种植体在种植初期也不会出现应力屏蔽的问题；且镁具有生物活性，镁离子能够促进细胞成长，有利于加速骨结合的进程。The porous dental implant with the surface inlaid with the degradable layer disclosed in the invention has a degradable layer embedded on the surface thereof, and the metal magnesium is melted by laser heating to adhere, and can well cover the rough surface of the pure titanium implant pile of the SLM printing. , to reduce the processing requirements of SLM printing; at the same time, the elastic modulus and yield strength of magnesium are close to the bone tissue, so that the porous dental implant does not have the problem of stress shielding in the initial stage of planting; and magnesium is biologically active, and magnesium ions can promote cells. Growing up helps speed up the process of osseointegration.
附图说明DRAWINGS
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例描述中所需要使用的附图作简单说明。显然，所描述的附图只是本发明的一部分实施例，而不是全部实施例，本领域的技术人员在不付出创造性劳动的前提下，还可以根据这些附图获得其他设计方案和附图。In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below. It is apparent that the described drawings are only a part of the embodiments of the present invention, and not all of the embodiments, and those skilled in the art can obtain other designs and drawings according to the drawings without any creative work.
图1是实施例1的种植体基桩示意图；1 is a schematic view of an implant pile of Embodiment 1;
图2是实施例1的表面镶嵌可降解层的多孔牙种植体的结构示意图；2 is a schematic structural view of a porous dental implant having a surface inlaid with a degradable layer of Example 1;
图3是实施例2的种植体基桩示意图；Figure 3 is a schematic view of the implant pile of the second embodiment;
图4是实施例2的表面镶嵌可降解层的多孔牙种植体的结构示意图。4 is a schematic view showing the structure of a porous dental implant having a surface inlaid with a degradable layer of Example 2.
具体实施方式Detailed ways
以下将结合实施例和附图对本发明的构思、具体结构及产生的技术效果进行清楚、完整地描述，以充分地理解本发明的目的、特征和效果。显然，所描述的实施例只是本发明的一部分实施例，而不是全部实施例，本发明的实施例，本领域的技术人员在不付出创造性劳动的前提下所获得的其他实施例，均属于本发明保护的范围。另外，文中所提到的所有联接/连接关系，并非单指构件直接相接，而是指可根据具体实施情况，通过添加或减少联接辅件，来组成更优的联接结构。本发明创造中的各个技术特征，在不互相矛盾冲突的前提下可以交互组合。The concept, the specific structure and the technical effects of the present invention will be clearly and completely described in conjunction with the embodiments and the accompanying drawings. It is apparent that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments, and other embodiments obtained by those skilled in the art without any inventive effort belong to the present invention. The scope of the invention is protected. In addition, all the coupling/joining relationships mentioned in the text are not directly connected to the components, but rather may constitute a better coupling structure by adding or reducing the coupling accessories according to the specific implementation. The various technical features in the creation of the invention can be combined and combined without conflicting conflicts.
实施例1：如图1和2所示，一种表面镶嵌可降解层的多孔牙种植体，通过SLM技术使用纯钛打印出种植体基桩1，所述种植体基桩1内具有多孔结构，其表面设有球形孔a2，种植体基桩1表面的球形孔a2与所述多孔结构连通，通过机械加工的方式对种植体基桩1的内螺纹以及六边形连接槽进行精加工，将熔点低于纯钛的金属镁颗粒放入球形孔a2中，采用激光照射加热镁颗粒使其温度瞬间提高到熔点，导致熔液可以迅速附着在球形孔a2上并且渗入填充局部或全部多孔结构形成可降解层a3，填充球形孔a2的可降解层a3冷却后突出于种植体基桩1表面。球形孔a2均匀排列的多孔种植体，该种植体可以保证提供充足的过盈量，并且保证种植体受力均匀。Embodiment 1: As shown in FIGS. 1 and 2, a porous dental implant having a surface inlaid with a degradable layer, the implant-based pile 1 is printed by using SLM technology using pure titanium, and the implant-based pile 1 has a porous structure. a spherical hole a2 is arranged on the surface thereof, and a spherical hole a2 on the surface of the implant pile 1 is connected with the porous structure, and the internal thread of the implant pile 1 and the hexagonal connecting groove are finished by mechanical processing. The metal magnesium particles having a melting point lower than that of pure titanium are placed in the spherical hole a2, and the magnesium particles are heated by laser irradiation to instantly increase the temperature to the melting point, so that the molten metal can quickly adhere to the spherical hole a2 and infiltrate into the partial or total porous structure. The degradable layer a3 is formed, and the degradable layer a3 filling the spherical hole a2 is cooled and protrudes from the surface of the implant pile 1. A porous implant in which the spherical holes a2 are evenly arranged, the implant can ensure sufficient interference and ensure uniform stress on the implant.
实施例2：如图3和4所示，其与实施例1的区别点在于将球形孔替换成螺纹槽b2。填充螺纹槽b2且突出的可降解层b3能充当临时的螺纹牙，方便安装固定。Embodiment 2: As shown in Figs. 3 and 4, it differs from Embodiment 1 in that a spherical hole is replaced with a thread groove b2. The degradable layer b3 which fills the thread groove b2 and protrudes can serve as a temporary thread to facilitate mounting and fixing.
SLM技术结合机加工与激光加工的方式，缩短了牙种植体的加工周期，保证了其整体性与结构强度。并且这种加工方式可以忽略SLM加工的误差，减少了成本。镶嵌的可降解层凸出于表面，均匀分布，保证种植体受力均匀，并且手术操作方便，从而保证了种植体的初期稳定性与结构强度。种植初期稳定性较高并且生物相容性好，可降解层降解释放镁离子促进了骨细胞的再生。同时空出孔隙诱导骨细胞的长入，最终保证了骨结合的发生。从而提高了种植手术的成功率。并且本发明的种植体适用范围较广。SLM technology combines machining and laser processing to shorten the processing cycle of dental implants and ensure their integrity and structural strength. And this processing method can ignore the error of SLM processing and reduce the cost. The inlaid degradable layer protrudes from the surface and is evenly distributed to ensure uniform stress on the implant and convenient operation, thereby ensuring the initial stability and structural strength of the implant. The initial stability of planting is high and the biocompatibility is good. Degradation of the degradable layer releases magnesium ions to promote the regeneration of bone cells. At the same time, the vacancy of the pores induces the growth of bone cells, which ultimately ensures the occurrence of osseointegration. Thereby improving the success rate of implant surgery. Moreover, the implant of the present invention has a wide range of applications.
以上对本发明的较佳实施方式进行了具体说明，但本发明创造并不限于所述实施例，熟悉本领域的技术人员在不违背本发明精神的前提下还可作出种种的等同变型或替换，这些等同的变型或替换均包含在本申请权利要求所限定的范围内。The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the embodiments, and various equivalent modifications or substitutions can be made by those skilled in the art without departing from the spirit of the invention. These equivalent variations or alternatives are intended to be included within the scope of the claims.

Claims (4)

  1. 一种表面镶嵌可降解层的多孔牙种植体的制备方法，其特征在于包括以下步骤： A method for preparing a porous dental implant having a surface inlaid with a degradable layer, comprising the steps of:
    （1）通过SLM技术使用纯钛打印出种植体基桩，其表面设有球形孔或螺纹槽；(1) The implant-based pile is printed by pure titanium using SLM technology, and the surface thereof is provided with a spherical hole or a thread groove;
    （2）通过机械加工的方式对种植体基桩的内螺纹以及六边形连接槽进行精加工；(2) finishing the internal thread of the implant pile and the hexagonal joint groove by means of machining;
    （3）将熔点低于纯钛的金属镁颗粒放入球形孔或螺纹槽中，采用激光照射加热镁颗粒使其温度瞬间提高到熔点，导致熔液可以迅速附着在球形孔或螺纹槽上形成可降解层，待种植体基桩冷却后即可得到牙种植体。(3) The metal magnesium particles having a melting point lower than that of pure titanium are placed in a spherical hole or a thread groove, and the magnesium particles are heated by laser irradiation to instantly increase the temperature to the melting point, so that the molten metal can be quickly attached to the spherical hole or the thread groove. Degradable layer, the dental implant can be obtained after the pile of the implant is cooled.
  2. 一种由权利要求1所述的制备方法制得的表面镶嵌可降解层的多孔牙种植体。A porous dental implant having a surface-degradable layer prepared by the preparation method according to claim 1.
  3. 根据权利要求2所述的多孔牙种植体，其特征在于：包括种植体基桩，所述种植体基桩内具有多孔结构，种植体基桩表面的球形孔或螺纹槽与所述多孔结构连通，可降解层渗入填充局部或全部多孔结构。The porous dental implant according to claim 2, comprising: an implant-based pile, wherein the implant-based pile has a porous structure, and a spherical hole or a threaded groove on the surface of the implant-based pile is connected to the porous structure. The degradable layer penetrates into the filled partial or total porous structure.
  4. 根据权利要求2所述的多孔牙种植体，其特征在于：填充球形孔或螺纹槽的可降解层突出于种植体基桩表面。 The porous dental implant according to claim 2, wherein the degradable layer filled with the spherical hole or the thread groove protrudes from the surface of the implant pile.
PCT/CN2018/073414 2017-12-01 2018-01-19 Porous dental implant having surface inlaid with degradable layer and preparation method therefor WO2019104852A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201711250259.1A CN108114322A (en) 2017-12-01 2017-12-01 A kind of porous tooth implant of surface inserting biodegradable layer and preparation method thereof
CN201711250259.1 2017-12-01

Publications (1)

Publication Number Publication Date
WO2019104852A1 true WO2019104852A1 (en) 2019-06-06

Family

ID=62228874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/073414 WO2019104852A1 (en) 2017-12-01 2018-01-19 Porous dental implant having surface inlaid with degradable layer and preparation method therefor

Country Status (2)

Country Link
CN (1) CN108114322A (en)
WO (1) WO2019104852A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11872105B1 (en) 2022-12-01 2024-01-16 Robert Parker Dental implant device for regeneration of dental pulp and dentin
US11931224B1 (en) 2022-12-19 2024-03-19 Robert Parker Tooth pod

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN208823014U (en) * 2017-12-01 2019-05-07 广州市健齿生物科技有限公司 A kind of porous dental implant of degradable magnesium ion
KR102115229B1 (en) * 2018-06-20 2020-05-27 한국생산기술연구원 One-step manufacturing method of laminated molding porous component which has curved surface
KR102115225B1 (en) * 2018-06-20 2020-05-27 한국생산기술연구원 One-step manufacturing method of laminated molding porous component
CN110742705B (en) * 2019-10-28 2021-04-13 西安交通大学 Porous ultrashort implant filled with degradable ceramic and preparation method thereof
CN110899688A (en) * 2019-11-29 2020-03-24 广州市健齿生物科技有限公司 Preparation method of dental implant blank

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103357063A (en) * 2012-04-10 2013-10-23 中国科学院金属研究所 Metal composite material capable of inducing bone growth and application thereof
CN106109032A (en) * 2016-06-27 2016-11-16 西北有色金属研究院 A kind of gradient porous structure tooth implant
CN205698065U (en) * 2016-02-23 2016-11-23 浙江工业大学 The porous tooth implant of drug-carrying slow-released system
US20170189276A1 (en) * 2015-04-29 2017-07-06 DENTSPLY SIRONA, Inc. Method for creating a Mineral Trioxide Aggregate material with improved biological effects
CN107126281A (en) * 2017-05-17 2017-09-05 上海交通大学 A kind of high intensity Low rigidity porous titanium implant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006036039A1 (en) * 2006-08-02 2008-02-07 Forschungszentrum Jülich GmbH Porous outer layer implants and methods of making same
JP4321636B2 (en) * 2007-07-27 2009-08-26 セイコーエプソン株式会社 Method for producing dental implant
KR20090014027A (en) * 2007-08-03 2009-02-06 쿱케앤볼프주식회사 코리아 Members for dental implant and method of fabricating the same, and dental implant comprising the members
CN102715960A (en) * 2012-06-01 2012-10-10 上海交通大学 Dental implant and preparation method thereof
CN105603277A (en) * 2015-12-28 2016-05-25 青岛博泰美联化工技术有限公司 Easily-degraded medical magnesium-alloy material and preparation method thereof
CN105662621B (en) * 2016-02-23 2018-10-19 浙江工业大学 A kind of porous dental implant and its manufacturing method of drug-carrying slow-released system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103357063A (en) * 2012-04-10 2013-10-23 中国科学院金属研究所 Metal composite material capable of inducing bone growth and application thereof
US20170189276A1 (en) * 2015-04-29 2017-07-06 DENTSPLY SIRONA, Inc. Method for creating a Mineral Trioxide Aggregate material with improved biological effects
CN205698065U (en) * 2016-02-23 2016-11-23 浙江工业大学 The porous tooth implant of drug-carrying slow-released system
CN106109032A (en) * 2016-06-27 2016-11-16 西北有色金属研究院 A kind of gradient porous structure tooth implant
CN107126281A (en) * 2017-05-17 2017-09-05 上海交通大学 A kind of high intensity Low rigidity porous titanium implant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11872105B1 (en) 2022-12-01 2024-01-16 Robert Parker Dental implant device for regeneration of dental pulp and dentin
US11931224B1 (en) 2022-12-19 2024-03-19 Robert Parker Tooth pod

Also Published As

Publication number Publication date
CN108114322A (en) 2018-06-05

Similar Documents

Publication Publication Date Title
WO2019104852A1 (en) Porous dental implant having surface inlaid with degradable layer and preparation method therefor
JP5318864B2 (en) Surgical implant composed of a porous core and a dense surface layer
CN103892930B (en) The tooth implant of the molten attaching organism activity glass ceramic artificial bone powder of zirconia ceramics
Clayton et al. The effect of luting agents on the retention and marginal adaptation of the CeraOne implant system.
Sinha et al. Versatility of PEEK as a fixed partial denture framework
CN106421904A (en) Method for preparing porous implant through gelcasting 3D printing and electroreduction
KR100809574B1 (en) Bio-affinity implant
NZ258662A (en) Treating a metallic surgical implant with an aqueous solution containing sodium fluoride
US20130150227A1 (en) Composite Bio-Ceramic Dental Implant and Fabricating Method Thereof
US20110195378A1 (en) Composite Bio-Ceramic Dental Implant and Fabricating Method Thereof
CN109364292A (en) A kind of preparation method and products thereof of magnesium-based composite material bone implant
WO2019218583A1 (en) Porous dental implant internally combined with biodegradable magnesium alloy and manufacturing method therefor
CN102113918B (en) Method for preparing porous structure on surface of pure titanium dental implant
WO2019104853A1 (en) Porous dental implant capable of degrading so as to release magnesium ions
CN114099079A (en) 3D prints individualized alveolar bone defect and rebuilds with degradable magnesium net
Veerareddy et al. Simplified technique for orbital prosthesis fabrication: a clinical report
CN108004527A (en) A kind of preparation method of zinc doping hydroxyapatite coating layer for magnesium alloy materials
CN205339653U (en) Medical tooth planting body with surface is biological bionical
CN203873903U (en) Dental implant of zirconium oxide ceramic fused bioactive glass ceramic artificial bone dust
KR102115225B1 (en) One-step manufacturing method of laminated molding porous component
Weidong et al. Biocompatibility of a functionally graded bioceramic coating made by wide‐band laser cladding
Betelak et al. The use of titanium implants and prosthodontic techniques in the preparation of non-human primates for long-term neuronal recording studies
Sharma et al. Implant-Supported Auricular Prosthesis-An Overview.
KR102115229B1 (en) One-step manufacturing method of laminated molding porous component which has curved surface
CN105948509B (en) A kind of glass ceramics of porosity for tooth-implanting

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18883981

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18883981

Country of ref document: EP

Kind code of ref document: A1