WO2019097618A1 - Accélérateur de rayons de particules et dispositif thérapeutique à rayons de particules l'utilisant - Google Patents

Accélérateur de rayons de particules et dispositif thérapeutique à rayons de particules l'utilisant Download PDF

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Publication number
WO2019097618A1
WO2019097618A1 PCT/JP2017/041160 JP2017041160W WO2019097618A1 WO 2019097618 A1 WO2019097618 A1 WO 2019097618A1 JP 2017041160 W JP2017041160 W JP 2017041160W WO 2019097618 A1 WO2019097618 A1 WO 2019097618A1
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particle beam
beam accelerator
magnetic pole
magnetic poles
plane
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PCT/JP2017/041160
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English (en)
Japanese (ja)
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知新 堀
孝道 青木
孝義 関
隆光 羽江
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株式会社日立製作所
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Priority to PCT/JP2017/041160 priority Critical patent/WO2019097618A1/fr
Publication of WO2019097618A1 publication Critical patent/WO2019097618A1/fr

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    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H13/00—Magnetic resonance accelerators; Cyclotrons

Definitions

  • the present invention relates to a particle beam accelerator and a particle beam treatment apparatus provided with the same.
  • the synchrocyclotron comprises a ferromagnetic structure having a generally circular cross-section of radius R and disposed on either side of the median plane and having a pair of poles centered on a central axis.
  • the poles are separated by a gap forming a cavity having a substantially symmetrical profile with respect to the median plane.
  • the height of the gap varies in the radial direction, and the profile of the gap is, in order from the central axis, the first portion of a circular cross-section of radius R2 centered on the central axis, the height of the gap at that center Is equal to H center and the height of the gap gradually increases towards the maximum value H max at radius R 2, the first part and the first part surrounding the height of the gap at the pole edge And a second portion of the annular cross section gradually decreasing towards the height H edge .
  • Patent Document 1 discloses a magnetic particle shape of a particle beam accelerator called a synchrocyclotron included in a small particle beam therapy apparatus, in particular, a magnet apparatus for generating a magnetic field necessary for the synchrocyclotron. There is.
  • a particle beam accelerator called a circular accelerator includes an injection device including an ion source, a magnet device for generating a magnetic field for stably rotating the beam, an acceleration cavity for accelerating the beam by applying a high frequency electric field, and an equilibrium orbit for the beam. And a beam extraction magnet for applying a magnetic field for purposely shifting, and an emission channel for extracting the beam deviated from the equilibrium orbit out of the accelerator.
  • Synchrocyclotron is a device that generates a magnetic field with a magnet device and modulates the frequency of the high frequency electric field to the energy of the beam to align the beam passage timing with the phase of the high frequency electric field to accelerate the beam to the desired energy It is.
  • the beam is accelerated in the magnetic field, so the higher the energy, the wider the trajectory drawn by the beam.
  • the beam accelerated to the maximum energy of the accelerator is intentionally shifted from the equilibrium orbit by the extraction magnet being applied with a magnetic field for extraction, and is extracted from the emission channel to the outside of the accelerator.
  • the energy of a beam irradiated to a tumor needs to be adjusted according to the depth from the body surface of the tumor. Therefore, the beam accelerated to the highest energy and taken out of the synchrocyclotron usually passes through a scatterer called a degrader to reduce the energy before irradiating the tumor. Radiation is generated during the passage of the degrader. Also, the beam current is reduced by the passage of the degrader. A decrease in beam current leads to a decrease in throughput, since a higher beam current is better for irradiating the beam dose necessary for treating a tumor in a short time.
  • the beam passes near the corresponding emission channel even when no extraction magnetic field is applied.
  • an accelerator with a magnet assembly that generates a magnetic field such that a wide energy band beam passes near one exit channel is desired.
  • the problem to be solved by the present invention is that, in a particle beam accelerator provided with an acceleration cavity capable of frequency modulation, a magnet capable of generating a magnetic field such that a beam with a wide energy band passes near the emission channel. It is providing a particle beam accelerator equipped with an apparatus, and providing a particle beam therapy apparatus equipped with the particle beam accelerator.
  • the present invention includes a plurality of means for solving the above-mentioned problems, and an example thereof is a particle beam accelerator, which is a magnet device generating a magnetic field therebetween, and ions are incident between the magnet devices.
  • An ion source a high frequency electric field for accelerating the ions, an acceleration cavity capable of modulating the frequency of the high frequency electric field, and a beam emission path for taking out the ions to the outside; It has a pair of magnetic poles fixed to the yoke and the return yoke, and each of the pair of magnetic poles is arranged with one or more small magnetic poles on the opposing surface facing the intermediate plane in the space between the pair of magnetic poles
  • the small magnetic pole is plane-symmetrical to one vertical plane including the middle plane and one symmetry axis perpendicular to the middle plane, and arranged non-axially symmetrical to the symmetry axis Characterized in that it is.
  • a beam of a wide energy band can be passed near the exit channel, and a beam of an energy band with a significant width can be extracted from the same exit channel.
  • FIG. 2 is a perspective view of a magnet apparatus disposed in a particle beam accelerator of the particle beam therapy system in Embodiment 1.
  • FIG. 2 is a cross-sectional view of the magnet device in Example 1 taken along a vertical plane.
  • FIG. 5 is a plan view of the magnet device in Embodiment 1 as seen from an intermediate plane. It is a contour of the ideal magnetic field which the magnet apparatus in Example 1 should produce
  • FIG. 16 is a plan view of the magnet device in Example 2 as seen from an intermediate plane thereof. It is sectional drawing by the vertical plane of the magnet apparatus arrange
  • FIG. 18 is a plan view of the magnet device in Example 3 as seen from an intermediate plane thereof.
  • Example 1 A particle beam accelerator and a particle beam treatment apparatus according to a first embodiment of the present invention will be described with reference to FIGS. 1 to 6.
  • FIG. 1 is a block diagram of the particle beam therapy system in the first embodiment.
  • the particle beam therapy system 1001 is disposed in a building (not shown) and is installed on the floor of the building.
  • the particle beam therapy system 1001 includes an ion beam generator 1002, a beam transport system 1013, a rotating gantry 1006, an irradiation system 1007 and a control system 1065.
  • the ion beam generator 1002 has an ion source 1003 and an accelerator 1004 to which the ion source 1003 is connected.
  • the beam transport system 1013 has a beam path 1048 that reaches the irradiation device 1007.
  • a plurality of quadrupole electromagnets 1046, deflection electromagnets 1041, a plurality of quadrupole electromagnets are directed from the accelerator 1004 to the irradiation device 1007.
  • a deflection electromagnet 1042, quadrupole electromagnets 1049 and 1050, and deflection electromagnets 1043 and 1044 are arranged in this order.
  • a part of the beam path 1048 of the beam transport system 1013 is installed in the rotating gantry 1006, and the deflection electromagnet 1042, the quadrupole electromagnets 1049 and 1050, and the deflection electromagnets 1043 and 1044 are also installed in the rotation gantry 1006.
  • the beam path 1048 is connected to an exit channel (beam exit path) 1019 provided in the accelerator 1004.
  • the rotating gantry 1006 is a rotating device that is rotated around a rotating shaft 1045 and pivots the irradiation device 1007 around the rotating shaft 1045.
  • the irradiation apparatus 1007 includes two scanning electromagnets 1051 and 1052, a beam position monitor 1053 and a dose monitor 1054.
  • the scanning electromagnets 1051 and 1052, the beam position monitor 1053 and the dose monitor 1054 are disposed along the central axis of the irradiation device 1007, that is, the beam axis.
  • the scanning electromagnets 1051 and 1052, the beam position monitor 1053 and the dose monitor 1054 are disposed in a casing (not shown) of the irradiation device 1007, and the beam position monitor 1053 and the dose monitor 1054 are disposed downstream of the scanning electromagnets 1051 and 1052.
  • the scanning electromagnet 1051 and the scanning electromagnet 1052 respectively deflect the ion beam and scan the ion beam in directions orthogonal to each other in a plane perpendicular to the central axis of the irradiation apparatus 1007.
  • the irradiation device 1007 is attached to the rotating gantry 1006 and disposed downstream of the deflection electromagnet 1044.
  • a treatment table 1055 on which the patient 1056 lies is disposed to face the irradiation device 1007.
  • the control system 1065 has a central control unit 1066, an accelerator / transport system control unit 1069, a scan control unit 1070, a rotation control unit 1088, and a database 1072.
  • Central controller 1066 has central processing unit (CPU) 1067 and memory 1068 connected to CPU 1067.
  • CPU central processing unit
  • the accelerator / transport system controller 1069, the scan controller 1070, the rotation controller 1088, and the database 1072 are connected to the CPU 1067.
  • the particle beam therapy system 1001 has a treatment planning device 1073, and the treatment planning device 1073 is connected to the database 1072.
  • the beam current measuring device 1098 includes a moving device 1017 and a position detector 1039.
  • the high frequency power supply 1036 inputs electric power to the high frequency cavity 1037 installed in the accelerator 1004 through the waveguide 1010, excites a high frequency electric field between the electrode connected to the high frequency cavity 1037 and the ground electrode, and accelerates the ion beam Do.
  • the resonant frequency of the accelerating cavity needs to be modulated correspondingly to the energy of the beam.
  • the inductance or capacitance may be adjusted. For example, in the case of adjusting the capacitance, a variable capacitance capacitor is connected to the high frequency cavity for control.
  • FIG. 2 is a perspective view of the magnet device 1 constituting the accelerator 1004.
  • FIG. 3 is a cross-sectional view of the magnet assembly 1 taken along the vertical plane 3.
  • FIG. 4 is a plan view of the magnet device 1 as viewed from the intermediate plane 2.
  • FIG. 5 is a contour line of an ideal magnetic field that the magnet device 1 should generate in the middle plane 2.
  • FIG. 6 shows an ideal magnetic field that the magnet device 1 should generate on the line of intersection of the middle plane 2 and the vertical plane 3.
  • the accelerator 1004 includes a magnet device 1 for generating a magnetic field between them, an ion source 1003 for causing ions to enter between the magnet devices 1, and an emission channel 1019 for extracting ions to the outside. There is.
  • the magnet device 1 mainly has an upper return yoke 4 and a lower return yoke 5 which have a substantially disk shape when viewed from the vertical direction.
  • the upper return yoke 4 and the lower return yoke 5 have a substantially vertically symmetrical shape with respect to the intermediate plane 2.
  • the intermediate plane 2 passes generally through the vertical center of the magnet assembly 1 and substantially coincides with the orbital plane drawn by the accelerating ions.
  • the upper return yoke 4 and the lower return yoke 5 have a plane-symmetrical shape with respect to the vertical plane 3 which is a plane perpendicular to the middle plane 2 and passing through the center of the magnet assembly 1 with respect to the middle plane 2.
  • the intersection of the intermediate plane 2 with the magnet device 1 is indicated by an alternate long and short dash line, and the intersection of the vertical plane 3 with the magnet device 1 is indicated by a broken line.
  • An ion source 1003 is disposed in the upper return yoke 4.
  • FIG. 3 is a cross-sectional view of the magnet assembly 1 according to the vertical plane 3.
  • the coil 6 is disposed in plane symmetry with respect to the intermediate plane 2 in the space surrounded by the upper return yoke 4 and the lower return yoke 5.
  • the coil 6 is connected to a coil excitation power supply 1057 by a coil lead wire 1022 shown in FIG.
  • the coil 6 is a superconducting coil, is installed inside a cryostat (not shown), and is cooled by heat transfer from a refrigerant such as liquid helium or a refrigerator (not shown).
  • a vacuum vessel 7 is provided inside the coil 6 in the space surrounded by the upper return yoke 4 and the lower return yoke 5.
  • the upper magnetic pole 8 is on the surface facing the lower return yoke 5 of the upper return yoke 4
  • the lower magnetic pole 9 is on the surface facing the upper return yoke 4 of the lower return yoke 5. They are disposed in plane symmetry with respect to the plane 2 and coupled to the upper return yoke 4 and the lower return yoke 5 respectively.
  • a space for orbiting and accelerating the ion beam is formed between the upper magnetic pole 8 and the lower magnetic pole 9.
  • Extraction electromagnets 11 and 12 are disposed parallel to the intermediate plane 2 between the upper magnetic pole 8 and the lower magnetic pole 9.
  • the extraction electromagnets 11 and 12 are connected to the extraction electromagnet power supply 1040 from the through hole 14 by the extraction electromagnet extraction wire 1023 shown in FIG.
  • the emission channel 1019 is disposed on the outer peripheral side between the upper magnetic pole 8 and the lower magnetic pole 9, and includes an electromagnet (not shown).
  • the emission channel 1019 is connected to the emission channel power supply 1082 shown in FIG. By supplying current from the emission channel power supply 1082 to the electromagnet provided in the emission channel 1019, the ion beam that has reached the emission channel 1019 is arranged and sent to the beam transport system 1013.
  • a magnetic field correction electromagnet (coil) 23 for adjusting a magnetic field is disposed in plane symmetry with respect to the intermediate plane 2.
  • FIG. 4 is a plan view of the facing surface 10 as viewed from the intermediate plane 2.
  • the magnet device 1 has a plane-symmetrical structure with respect to 2 in the middle plane, and therefore, the detailed structure of the magnet device 1 will be described below with reference to FIGS. 3 and 4.
  • the upper magnetic pole 8 and the lower magnetic pole 9 have axially symmetrical irregularities 15a, 15b, 15c, 15d, 15e having axisymmetric shapes with respect to a symmetry axis 20 perpendicular to the intermediate plane 2 through the point O1 on the opposing surface 10. ing.
  • the axially symmetric unevenness 15e provided on the outermost side has a notch 16 in a part in the circumferential direction.
  • These axially symmetrical irregularities 15a, 15b, 15c, 15d, and 15e may be integrally formed with the upper magnetic pole 8 and the lower magnetic pole 9, or may be engaged during assembly after being manufactured as separate members It may be
  • the small magnetic poles 17 a, 17 b and 17 c are arranged non-axially symmetric with respect to the symmetry axis 20.
  • the small magnetic poles 17a, 17b and 17c may also be integrally formed with the upper magnetic pole 8 and the lower magnetic pole 9, or may be engaged during assembly after being manufactured as separate members Good.
  • the area of the small magnetic pole 17a when projected onto the intermediate plane 2 is the smallest, and is arranged at a position closest to the incident position of ions.
  • the small magnetic pole 17a is provided with the end of the through hole 24 opposite to the end connected to the ion source 1003.
  • the small magnetic pole 17a is designed to have the longest length along the symmetry axis 20, and the distance between the upper magnetic pole 8 and the lower magnetic pole 9 is shortest. It is designed.
  • the small magnetic pole 17b is disposed closer to the ion incident position.
  • the through hole 18 shown in FIG. 4 is a through hole for installing the beam transport system 1013.
  • the through holes 19 are provided so as to be plane-symmetrical to the through holes 18 with respect to the vertical plane 3 in order to enhance the symmetry of the magnet device 1 and to improve the accuracy of the magnetic field generated by the magnet device 1.
  • the radius of the beam trajectory As the magnetic field generated by the magnet device 1 is larger, the spread of the beam trajectory is smaller, and the accelerator 1004 and hence the particle beam therapy system 1001 can be miniaturized.
  • the magnetic field at the incident point is 5 T
  • the beam radius of the highest energy is 1 m.
  • an ideal magnetic field distribution in which the beam travels stably is determined.
  • the magnetic field is designed in the present embodiment based on the principle of weak focusing.
  • n index n ⁇ ( ⁇ / B) ( ⁇ B / ⁇ r) (1)
  • B is the magnetic field in the intermediate plane 2
  • ⁇ is the radius of curvature of the beam trajectory
  • the magnetic field gradient ⁇ ⁇ B / ⁇ r is perpendicular to the beam traveling direction on the intermediate plane 2 and beam energy Shows the derivative of the magnetic field with respect to the direction in which
  • ⁇ B / ⁇ r should be smaller than 0 at ⁇ 1 T / m or more.
  • the beam spacing passing near the exit channel which is the main object of the present invention, was determined.
  • the beam trajectory from the incident energy to the highest energy is confined to the width of 0.1 m.
  • the magnetic field for the highest energy is 4.9 T.
  • the magnetic field of the outermost periphery is set to 4.95 T with a margin.
  • the magnetic field distribution on the plane on which the beam balance orbits are determined and the magnetic field distribution on the Y axis is shown in FIG. 6 determined by the above steps.
  • the point O1 in FIG. 5 is the center of the beam trajectory with the highest energy, and the point O2 is the incident position.
  • the plane on which the beam balance orbits is taken on the XY plane, the straight line connecting the points O1 and O2 is taken as the Y axis, and the X axis is taken perpendicular to the Y axis passing through the point O1.
  • the required magnetic field is non-axisymmetric with respect to an axis perpendicular to the XY plane through the point O1 and symmetrical about the Y.
  • Magnetic field There is a magnetic field peak at point O2, and the magnetic field gradient is steep in the direction from the point O2 toward the Y-axis negative direction, ie, the direction of the exit channel 1019, during which all beams from incident energy to the highest energy pass .
  • the magnetic field of 4.95 T serving as the base is represented by the coil 6, the upper return yoke 4, the lower return yoke 5, the upper magnetic pole 8, the lower magnetic pole 9, and the axially symmetrical irregularities 15a, 15b, 15c, 15d, 15e. It should be generated.
  • the diameters of the top pole 8 and the bottom pole 9 were 10% larger than the maximum trajectory radius of the beam.
  • the number of the axially symmetrical irregularities 15 a, 15 b, 15 c, 15 d and 15 e is determined based on the accuracy required for the magnetic field generated in the intermediate plane 2. Generally, the relative accuracy of the magnetic field required for the magnetic field of the accelerator magnet system is about 10 -4 . In the present embodiment, this accuracy is secured by providing five axisymmetric irregularities 15a, 15b, 15c, 15d and 15e. In addition, as for the axisymmetric irregularities, it is desirable to provide the optimum number according to the accuracy of the magnetic field to be obtained.
  • the axisymmetric unevenness 15e is provided with the notch 16.
  • a non-axisymmetric magnetic field is generated by the small magnetic poles 17a, 17b and 17c.
  • the protruding small magnetic pole 17a is required.
  • the magnetic field generated by the protruding small magnetic pole 17a spreads radially with the point O2 as the approximate center, but even if a magnetic field of the same sign as the base magnetic field is generated at the point O2, it reverses the base magnetic field after a certain distance It is necessary to generate a magnetic field of The small magnetic pole 17b and the small magnetic pole 17c are required to correct this.
  • the small magnetic pole 17 a and the small magnetic pole 17 c that correct it have a substantially fan-like shape. Axisymmetric shape is adopted.
  • the magnet device 1 having the magnetic pole shape as shown in FIG. 3 and FIG. 4 is designed.
  • the particle beam therapy system 1001 of the first embodiment described above includes an accelerator 1004.
  • the accelerator 1004 applies a high frequency electric field for accelerating ions, by applying a high frequency electric field for accelerating ions, by applying a magnet device 1 generating a magnetic field between them, an ion source 1003 for injecting ions between the magnet devices 1, and the frequency of the high frequency electric field can be modulated.
  • the magnet assembly 1 comprises an upper return yoke 4, a lower return yoke 5 and an upper return yoke 4, an upper magnetic pole 8 fixed to the lower return yoke 5, and a high frequency cavity 1037 and an emission channel 1019 for extracting ions to the outside.
  • the upper magnetic pole 8 and the lower magnetic pole 9 have small magnetic poles 17a, 17b and 17c on the facing surface 10 facing the intermediate plane 2 in the space between the upper magnetic pole 8 and the lower magnetic pole 9 respectively.
  • the small magnetic poles 17a, 17b, 17c are arranged relative to one vertical plane 3 including one symmetry axis 20 perpendicular to the middle plane 2 and the middle plane 2 which are arranged one or more.
  • the accelerator 1004 according to the present embodiment is capable of extracting a beam of energy band having a dominant width from the same emission channel without using a degrader, so a structure provided for activation of the degrader is adopted. There is no need. For this reason, it is possible to reduce the thickness of the shielding member provided for activation of the degrader as compared with the case of using the degrader, and it is possible to reduce the installation area of the device building and reduce the construction cost.
  • the small magnetic pole 17a having two or more small magnetic poles 17a, 17b, 17c and having the smallest area when the small magnetic poles 17a, 17b, 17c are projected onto the intermediate plane 2 has the longest length along the symmetry axis 20 Since it is long and the distance between the upper magnetic pole 8 and the lower magnetic pole 9 is the shortest, the magnetic field having the largest gradient magnetic field from the incident position O2 to the vicinity of the emission channel 1019 while satisfying the weak convergence principle. Can be generated more easily.
  • the small magnetic pole 17a closest to the incident position of the ion is provided with two or more small magnetic poles 17a, 17b and 17c, and the length along the symmetry axis 20 is longest. Even by having the shortest distance between the upper magnetic pole 8 and the lower magnetic pole 9, the magnetic field having the largest gradient magnetic field from the incident position O2 to the vicinity of the emission channel 1019 is satisfied while satisfying the weak convergence principle. It can be generated more easily.
  • the magnetic poles have weak convergence due to having at least one or more, particularly five or more, in the facing surface 10, at least one, particularly five or more, axially symmetrical irregularities 15a, 15b, 15c, 15d, 15e that are axially symmetrical with respect to the symmetry axis 20.
  • a magnetic field having the largest gradient magnetic field can be generated with higher precision from the incident position O2 to the vicinity of the exit channel 1019 while satisfying the principle.
  • the axially symmetrical irregularity 15e provided on the outermost side has the notch 16 in a part in the circumferential direction.
  • the exit channel 1019 can be arranged in a part, and the exit channel 1019 can be arranged closer to the orbiting beam trajectory.
  • the magnetic field in the vicinity of the emission channel 1019 can be lowered, and the magnetic field for beam extraction can be applied to the beam on the orbit with higher accuracy, so that the beam extraction becomes easier.
  • the place where the magnetic field strength needs to be the strongest can be set as the ion incident point O2.
  • the adjustment of the magnetic field becomes easier, so that the principle of weak convergence is satisfied and the incident position O2
  • the magnetic field having the largest gradient magnetic field can be generated with higher accuracy from the point to the vicinity of the exit channel 1019.
  • the ion source 1003 is installed outside the magnet apparatus 1 assuming the external ion source, and the through hole 24 is provided correspondingly to this, but the ion source 1003 is a magnet. It can be installed inside the device 1.
  • the through holes 24 are used to supply the ion source 1003 with electric power, a gas for ion generation, and the like.
  • FIG. 7 is a cross-sectional view of the magnet device 1 according to the second embodiment taken along the vertical plane 3
  • FIG. 8 is a plan view of the facing surface 10 A of the magnet device according to the second embodiment as viewed from the intermediate plane 2.
  • the magnetic field to be generated by the magnet device is the same as the magnet device 1 of the first embodiment.
  • the small magnetic pole is a small magnetic pole 17d generating a peak magnetic field and the magnetic field generated by the small magnetic pole in the positive Y-axis direction, as in the first embodiment.
  • the small magnetic pole 17e and the small magnetic pole 17f are provided. This produces a magnetic field with a peak at point O2 and a steep slope towards exit channel 1019.
  • the small magnetic pole 17d has substantially the same shape as the small magnetic pole 17a of the first embodiment, the small magnetic pole 17e has the small magnetic pole 17b, and the small magnetic pole 17f has the same shape as the small magnetic pole 17c.
  • the opposing surface 10A opposed to the intermediate flat surface 2 of the upper magnetic pole 8A and the lower magnetic pole 9A has a slope relative to the intermediate flat surface 2 except for the small magnetic poles 17d, 17e and 17f. It has a sloped shape that is axisymmetric to the axis of symmetry 20. For this reason, the distance between the opposing surfaces 10A of the upper magnetic pole 8 and the lower magnetic pole 9 has local maximum values and local minimum values at the apexes 21a, 21b, 21c in the direction parallel to the intermediate plane 2.
  • the vertex 21a has a minimum value at the position of the intersection of the symmetry axis 20 and the facing surface 10A, and has a maximum value at the vertex 21b.
  • the vertex 21a of the slope in FIG. 7 is in the range of the width of the axisymmetric unevenness 15a in Example 1, the vertex 21b is in the range of the width of the axisymmetric unevenness 15b, and the vertex 21c is in the range of the width of the axisymmetric unevenness 15c. . Also by the magnetic pole shape of the present embodiment, it is possible to generate the base uniform magnetic field within the required accuracy range.
  • the opposing surfaces 10A of the upper magnetic pole 8A and the lower magnetic pole 9A have a slope relative to the intermediate plane 2 except for the small magnetic poles 17d, 17e and 17f.
  • the apexes 21a, 21b and 21c exist in the direction parallel to the intermediate plane 2 in the distance between the opposing surfaces 10A of the upper magnetic pole 8B and the lower magnetic pole 9B, and the apex 21a has a local minimum value at the intersection of the symmetry axis 20 and the opposing surface 10A.
  • Example 3 An accelerator and a particle beam therapy system according to a third embodiment of the present invention will be described with reference to FIG. 9 and FIG.
  • FIG. 9 is a cross-sectional view of the magnet device 1 according to the third embodiment taken along the vertical plane 3
  • FIG. 10 is a plan view of the facing surface 10 B of the magnet device 1 according to the third embodiment as viewed from the intermediate plane 2.
  • the magnetic field to be generated by the magnet device 1 is the same as the magnetic device 1 of the first embodiment or the magnet device of the second embodiment.
  • the surface of the upper magnetic pole 8B and the lower magnetic pole 9B along the direction of the symmetry axis 20 is small on the surface 10B of the upper magnetic pole 8B.
  • the magnetic poles 22a, 22b, 22c, 22d, 22e, and 22f are disposed in an overlapping manner.
  • these small magnetic poles 22a, 22b, 22c, 22d, 22e, 22f are also arranged in plane symmetry with respect to the vertical plane 3.
  • the small magnetic poles 22a, 22b, 22c, 22d, 22e and 22f are the narrowest in area when projected onto the intermediate plane 2, and the areas increase in order .
  • the small magnetic poles 22a, 22b, 22c, 22d, 22e and 22f may be integrally formed with the upper magnetic pole 8B and the lower magnetic pole 9B, or they are engaged at the time of assembly after being manufactured as separate members It may be one.
  • the upper return yoke 4, the lower return yoke 5, the coil 6, the upper magnetic pole 8, the lower magnetic pole 9, and the axisymmetric unevenness 15e generate a base magnetic field, and the small magnetic poles 22a, 22b, 22c, 22d, 22e, 22f
  • the magnetic field to be generated by the magnet device 1 is generated by superimposing the gradient magnetic field generated by.
  • the small magnetic pole 22a generates a peak magnetic field, and generates a steep gradient magnetic field in the direction from the point O2 to the emission channel 1019.
  • the small magnetic pole 22b, the small magnetic pole 22c, the small magnetic pole 22d, the small magnetic pole 22e, and the small magnetic pole 22f generate a gentle gradient magnetic field in the positive direction along the Y axis.
  • plural small magnetic poles 22a, 22b, 22c, 22d, 22e and 22f may be stacked on the surface of the facing surface 10B along the axis of symmetry 20. Similar effects to the accelerator and particle beam treatment apparatus of the first embodiment described above can be obtained.
  • the method of overlapping a large number of small magnetic poles 22a, 22b, 22c, 22d, 22e, 22f is advantageous as in the third embodiment. is there.
  • the small magnetic poles 22a, 22b, 22c, 22d, 22e, and 22f are formed by stacking a plurality of flat plates parallel to the intermediate plane 2, but these small magnetic poles are parallel to the vertical plane 3
  • a substantially block-shaped material can be disposed on the surfaces of the upper magnetic pole 8B and the lower magnetic pole 9B, and the upper magnetic pole 8B and the lower magnetic pole 9B can be integrally formed of one block material.
  • the present invention is not limited to the above embodiments, and includes various modifications.
  • the above embodiments have been described in detail in order to explain the present invention in an easy-to-understand manner, and are not necessarily limited to those having all the configurations described.
  • particles to be accelerated are not specified. That is, in the accelerators of the first to third embodiments, the frequency of the accelerating cavity is adjusted in accordance with each of whether the proton is supplied from the ion source 1003 or the heavy particle ion such as carbon is supplied from the ion source 1003. If so, the beam can be stably accelerated.
  • the axially symmetric unevenness 15 e has the notch 16
  • the axially symmetrical unevenness on the outermost peripheral side can be configured not to have the notch. In this case, it is desirable to dispose the emission channel 1019 on the outer peripheral side than the axisymmetric unevenness on the outermost peripheral side.
  • the particle beam therapy system 1001 is described to include the beam transport system 1013, the particle beam therapy system can directly connect the ion beam generator and the rotating gantry without providing the beam transport system.
  • the fixed irradiation apparatus can be used.
  • the number of irradiation devices is not limited to one, and a plurality of irradiation devices can be provided.
  • the scanning method using the scanning electromagnets 1051 and 1052 was described as the irradiation method, after expanding the distribution of particle beams such as the wobbler method and the double scatterer method, the shape of the target is adjusted using a collimator or a bolus.
  • the present invention can also be applied to irradiation methods for forming different dose distributions.
  • the application of the accelerator is not limited to particle beam therapy, and may be used for high energy experiments and the like.

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  • Plasma & Fusion (AREA)
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  • Particle Accelerators (AREA)

Abstract

La présente invention concerne un accélérateur (1004) équipé d'un dispositif magnétique (1) comprenant une culasse de retour supérieure (4), une culasse de retour inférieure (5), ainsi qu'un pôle magnétique de partie supérieure (8) et un pôle magnétique de partie inférieure (9) fixés sur la culasse de retour supérieure (4) et sur la culasse de retour inférieure (5). Le pôle magnétique de partie supérieure (8) et le pôle magnétique de partie inférieure (9) comprennent un ou plusieurs petits pôles magnétiques (17a, 17b, 17c) disposés sur une surface opposée (10), en face à face avec un plan médian (2) situé dans un espace entre le pôle magnétique de partie supérieure (8) et le pôle magnétique de partie inférieure (9). Les petits pôles magnétiques (17a, 17b, 17c) sont disposés de manière à être dans une symétrie planaire par rapport au plan médian (2) et à un plan orthogonal (3) qui comprend un axe de symétrie (20) orthogonal au plan médian (2), et à être non axisymétriques par rapport à l'axe de symétrie (20).
PCT/JP2017/041160 2017-11-15 2017-11-15 Accélérateur de rayons de particules et dispositif thérapeutique à rayons de particules l'utilisant WO2019097618A1 (fr)

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WO2019097618A1 true WO2019097618A1 (fr) 2019-05-23

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012195279A (ja) * 2011-02-28 2012-10-11 Mitsubishi Electric Corp 円形加速器および円形加速器の運転方法
JP2015536028A (ja) * 2012-09-28 2015-12-17 メビオン・メディカル・システムズ・インコーポレーテッド 磁場再生器

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012195279A (ja) * 2011-02-28 2012-10-11 Mitsubishi Electric Corp 円形加速器および円形加速器の運転方法
JP2015536028A (ja) * 2012-09-28 2015-12-17 メビオン・メディカル・システムズ・インコーポレーテッド 磁場再生器

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