WO2019088546A3 - 켄파울론 유도체의 줄기세포의 심근세포로의 분화 유도 용도 - Google Patents

켄파울론 유도체의 줄기세포의 심근세포로의 분화 유도 용도 Download PDF

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Publication number
WO2019088546A3
WO2019088546A3 PCT/KR2018/012555 KR2018012555W WO2019088546A3 WO 2019088546 A3 WO2019088546 A3 WO 2019088546A3 KR 2018012555 W KR2018012555 W KR 2018012555W WO 2019088546 A3 WO2019088546 A3 WO 2019088546A3
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WO
WIPO (PCT)
Prior art keywords
kenpaullone
cardiomyocyte
derivative
stem cell
inducing differentiation
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PCT/KR2018/012555
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English (en)
French (fr)
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WO2019088546A2 (ko
Inventor
황기철
임소연
김상우
이윤미
최정원
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가톨릭관동대학교산학협력단
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Publication of WO2019088546A2 publication Critical patent/WO2019088546A2/ko
Publication of WO2019088546A3 publication Critical patent/WO2019088546A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 켄파울론 유도체의 줄기세포의 심근세포로의 분화 유도 용도에 관한 것으로, 보다 상세하게는, 본 발명의 켄파울론 유도체는 줄기세포로부터 심근세포로의 분화 유도능이 우수하고, 켄파울론 유도체에 의해 분화 유도된 심근세포는 심근경색 등 심장질환의 치료적 효과가 우수하다.
PCT/KR2018/012555 2017-11-01 2018-10-23 켄파울론 유도체의 줄기세포의 심근세포로의 분화 유도 용도 WO2019088546A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170144854A KR102010922B1 (ko) 2017-11-01 2017-11-01 켄파울론 유도체의 줄기세포의 심근세포로의 분화 유도 용도
KR10-2017-0144854 2017-11-01

Publications (2)

Publication Number Publication Date
WO2019088546A2 WO2019088546A2 (ko) 2019-05-09
WO2019088546A3 true WO2019088546A3 (ko) 2019-06-27

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ID=66332894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/012555 WO2019088546A2 (ko) 2017-11-01 2018-10-23 켄파울론 유도체의 줄기세포의 심근세포로의 분화 유도 용도

Country Status (2)

Country Link
KR (1) KR102010922B1 (ko)
WO (1) WO2019088546A2 (ko)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006117212A2 (en) * 2005-05-04 2006-11-09 Develogen Aktiengesellschaft Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders
WO2008133904A1 (en) * 2007-04-23 2008-11-06 Stowers Institute For Medical Research Methods and compositions for stem cell self-renewal
KR20090059339A (ko) * 2007-12-06 2009-06-11 한국생명공학연구원 줄기세포에서 심장근육세포로의 분화를 촉진하는 화합물및 그 유도체
KR20090090586A (ko) * 2008-02-21 2009-08-26 한국생명공학연구원 배아줄기세포를 심근세포로 분화 유도하는 방법
US20090325288A1 (en) * 2006-04-28 2009-12-31 Asubio Pharma Co., Ltd. Method for inducing differentiation of pluripotent stem cells into cardiomyocytes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006117212A2 (en) * 2005-05-04 2006-11-09 Develogen Aktiengesellschaft Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders
US20090325288A1 (en) * 2006-04-28 2009-12-31 Asubio Pharma Co., Ltd. Method for inducing differentiation of pluripotent stem cells into cardiomyocytes
WO2008133904A1 (en) * 2007-04-23 2008-11-06 Stowers Institute For Medical Research Methods and compositions for stem cell self-renewal
KR20090059339A (ko) * 2007-12-06 2009-06-11 한국생명공학연구원 줄기세포에서 심장근육세포로의 분화를 촉진하는 화합물및 그 유도체
KR20090090586A (ko) * 2008-02-21 2009-08-26 한국생명공학연구원 배아줄기세포를 심근세포로 분화 유도하는 방법

Also Published As

Publication number Publication date
KR20190049234A (ko) 2019-05-09
KR102010922B1 (ko) 2019-08-14
WO2019088546A2 (ko) 2019-05-09

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