WO2019081671A1 - Appâts rodenticides - Google Patents

Appâts rodenticides

Info

Publication number
WO2019081671A1
WO2019081671A1 PCT/EP2018/079338 EP2018079338W WO2019081671A1 WO 2019081671 A1 WO2019081671 A1 WO 2019081671A1 EP 2018079338 W EP2018079338 W EP 2018079338W WO 2019081671 A1 WO2019081671 A1 WO 2019081671A1
Authority
WO
WIPO (PCT)
Prior art keywords
bait
hulls
anyone
mixture
day
Prior art date
Application number
PCT/EP2018/079338
Other languages
English (en)
Inventor
Rossi LUCIA
Massimo Tagliaro
Pierpaolo Zambotto
Original Assignee
Zapi Industrie Chimiche S.P.A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zapi Industrie Chimiche S.P.A filed Critical Zapi Industrie Chimiche S.P.A
Publication of WO2019081671A1 publication Critical patent/WO2019081671A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A01N25/004—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits rodenticidal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom

Definitions

  • the present invention relates to a rodenticide bait for preventing and treating infestations by the rodent species comprising natural substances, such as hulls of seeds or caryopses or a mixture thereof as active ingredients.
  • Rats and mice not only live a parasitic life, that impoverishes available food resources, but also they are carriers of diseases injurious to humans or domestic animals.
  • mice in your home or in public places can be very distressing. Mice can spread disease in their search for food and shelter, posing health risks particularly in kitchens and food storage areas. Mice can cause other problems, so taking action to eliminate a mouse infestation quickly is important
  • the available chemical disinfesting means can be subdivided into the following classes:
  • the attractants are used to attract the animals to precise places, overcoming the natural and innate suspiciousness of the rodent species.
  • pheromones natural specific smells
  • compounds not connected to natural hormonal smells which include: vegetable oils of various kinds, sugar, molasses, glycerol, salt, sodium glutamate, etc.
  • pheromones other volatile substances have proven to have good attractant efficacy and among them there is carbon disulphide, which is effective in increasing the bait consumption.
  • the chemosterilants have been finding application in more recent times. For example, the use of triethylene melamine is known, but it has a limit of not being able to sterilize males and females at the same time. The chemosterilants have also the limit of not being effective in only one administration. Although capable of eliminating up to 85% of the treated murine population and causing permanent sterility in surviving adult males, ochlorohydrin is not active on the young prepubertal, on the females of Rattus norvegicus and on both genders and all ages of the Mus musculus. In addition to these limitations, the chemosterilants cannot be used in case of massive infestation or where the presence of even a single Mus musculus cannot be tolerated.
  • Rodenticides are an efficient means of rodent control, but many people are reluctant to use poisonous chemicals around the home, especially in the presence of children and pets.
  • the wide class of chemical rodenticide products can be divided in two main categories: A) acute or single dose rodenticides and B) chronic (anticoagulants) or multiple-dose rodenticides.
  • Natural poisons ( ⁇ ') and synthetic poisons (A") belong to the first category: the natural ones ( ⁇ ') include scilliroside and strychnine, while synthetic poisons (A") include crimidine, sodium fluoroacetate and fluoroacetamide, zinc phosphide, norbomide, thallium sulfate and ANTU.
  • acute rodenticides A) are not effective as the chronic ones B), they can be validly used in emergency situations, when the rat population must be destroyed in the shortest time. However, they have many disadvantages, among which stands out extreme dangerousness for man and non-target species and increase of the rodents' suspiciousness.
  • the chronic rodenticides are anticoagulants that can be subdivided, according to the mode of action, into B1 ) first generation anticoagulants (multiple dose) and B2) second generation anticoagulants (single dose).
  • Warfarin, coumachlor, coumatetralyl, coumafuryl, pivaldione, diphacinone and chlorophacinone belong to the first set.
  • Bromadiolon, diphenacoum, brodifacoum and the most recent difethialone and flocoumafen belong to the second set.
  • rodents have developed resistance to existing rodenticides, there is a continuous need to develop new and potentially more toxic rodenticides.
  • the Applicant has surprisingly found that using natural substances, such as hulls of seeds or hulls of caryopses a disinfesting effect is obtained.
  • the solution provided by the present invention is a rodenticide bait comprising hulls of seeds or caryopsis or a mixture thereof as active ingredients and a rodent attractant.
  • hulls of seeds or caryopses significantly reduces the phenomena of rodents resistance to the rodenticides and such a composition can be made specific in the treatments, where resistance phenomena, due for example to anticoagulants, appear in a considerable way.
  • the invention provides a rodenticide bait comprising hulls of seeds or hulls of caryopses or a mixture thereof as an active ingredient and attractants.
  • the invention provides a rodenticide bait comprising an active ingredient and attractants, wherein the active ingredient consists of hull of seeds or hulls of caryopses or a mixture thereof.
  • the invention provides the use of such active ingredients for controlling rodents.
  • the invention provides a process for preparing such baits.
  • the invention provides a method of controlling rodents comprising placing the bait composition according to the invention at locations where said rodents live or where they pass.
  • Figure 1 describes the section of a seed, for example a soybean seed, in which the seed hull, also said seed coat, is clearly indicated.
  • Figure 2 describes hulls of caryopses (rice). A detail of the image, in which hulls of caryopsis are clearly indicated, has been enlarged for a better understanding.
  • the present invention provides a rodenticide bait comprising hulls of seeds, caryopsis or a mixture thereof as active ingredient and attractants.
  • the invention provides a rodenticide bait comprising an active ingredient and attractants, wherein the active ingredient consists of hull of seeds or hulls of caryopses or a mixture thereof.
  • active ingredient(s) or rodenticide active ingredient(s) refer to a rodenticide product that kill, control, or repel rodent pests.
  • hull refers to the outer hard and coriaceous layer of the seeds and caryopses as illustrated in Figures 1 and 2.
  • the term “hull” is otherwise known as "husk”, “shell”, “shuck”, “skin” or "rind”.
  • hull is interchangeable with the term “husk”, “shell”, “shuck”, “skin” or “rind” and intended to have the same meaning.
  • the term "attractant” or "bait attractant” are inert ingredients that act in one or several of the following ways: a) entice the rodent to approach the bait; b) entice the rodent to touch the bait; c) entice the rodent to consume the bait; e) entice the rodent to return to the bait. Inert ingredients that are able to achieve these goals belong to the group of food attractants.
  • binder indicates inert ingredients that help to compact the material during the pellet pressing phase, to obtain a better product quality.
  • rodent refers to rats and mice including Mus Musculus, Rattus Rattus and Rattus Norvegicus, and also to voles in particular Arvicola Microtus and Arvicola Terrestris.
  • seeds refers to soybeans, lentils, beans, peas, lupini beans, sunflower seeds or pumpkin seeds.
  • caryopses refers to rice, wheat, barley, oat, emmer, millet, or rye.
  • the active ingredient is hulls of caryopsis selected from rice hulls, wheat hulls, barley hulls, oat hulls, emmer hulls, millet hulls or the active ingredient is hulls of seeds selected from soybean hulls, and lentil hulls or a mixture thereof.
  • the active ingredient is hulls of a seed selected from soybean hulls, lentil hulls or a mixture thereof.
  • the active ingredient is hulls of a caryopsis selected from rice hulls, wheat hulls, barley hulls, oat hulls, emmer hulls, millet hulls or hulls of a seed selected from soybean hulls, and lentil hulls or a mixture thereof.
  • the active ingredient is rice hulls, soybean hulls or a mixture thereof.
  • the active ingredient is soybean hulls.
  • the active ingredient is rice hulls.
  • the amount of hulls of seeds or caryopsis according to the invention is from 40 to 99% by weight of the bait composition.
  • the amount of hulls of seeds or hulls of caryopsis according to the invention is from 70 to 99% by weight of the bait composition.
  • the amount of hulls of seeds or hulls of caryopsis according to the invention is from 80 to 99% by weight of the bait composition.
  • the amount of hulls of seeds or hulls of caryopsis according to the invention is from 90 to 99% by weight of the bait composition. In a further embodiment, the amount of rice hulls or soybean hulls according to the invention is from 70 to 99% by weight of the bait composition.
  • the amount of rice hulls or soybean hulls according to the invention is from 80 to 99% by weight of the bait composition.
  • the amount of rice hulls or soybean hulls according to the invention is from 90 to 99% by weight of the bait composition.
  • the amount of hulls of seeds or caryopsis according to the invention is from 50 to 95% by weight of the bait composition.
  • the amount of hulls of seeds or caryopsis according to the invention is from 70% to 95% by weight of the bait composition.
  • the amount of hulls of seeds or caryopsis according to the invention is from 80 to 95% by weight of the bait composition.
  • the hulls according to the invention can be obtained by dehulling process (or decortication) which removes the hulls of seeds or caryopses.
  • the hull is formed during the growing season and it is removed before using the seed or caryopses for food purposes.
  • the process for removing the hulls from caryopsis for example from rice uses a Rice Hulling Machine, wherein rice is passed through a series of sieves can be used to sift out debris. An air blower is then used to remove any top matter.
  • the machine is designed to mimic the action of hand-held stones.
  • the rice is loosened from the hull by rolling it in between two sheets of metal- coated abrasives. About 80 to 90 percent of the hull gets removed during this process.
  • the hulls of rice are then passed by conveyor to a stone reel that aspirates the waste hulls and moves the rice to a machine that separates the hulled from the unhulled grains. Shaking the kernels pushes the heavier unhulled grains to one side and the lighter-weight rice to the other side of the machine.
  • Unhulled caryopses are then siphoned to another set of shelling machines to complete the hulling process.
  • Removal of seeds hulls such as for example soybean hulls, traditionally is done by passing the seeds through cracking rolls to fracture the hulls and an aspirator is then used to separate the hulls from the cotyledons in the crushed soybeans.
  • Active ingredients according to the invention can be commercially available.
  • rice hulls can be commercially available by Agromil Cereali SrL, whilst soybean hulls can be commercially available by Cereal Doks SpA.
  • Previously described rodenticides are produced in form of baits to be assimilated by the infesting rodent species.
  • the baits are produced by combining a rodenticide with a component (carrier) having an attractant baiting effect.
  • Useful attractants according to the invention include water, cereal powders such as wheat flour, maize flour, malts flour, rice flour, rice bran powder, oat flour, oatmeal and the like, starches such as potato starch, maize starch and the like, sugars such as sucrose, dextrose, brown sugar that is sucrose sugar product with a distinctive brown color due to the presence of molasses.
  • Useful attractants include also sweeteners like sorbitol, mannitol, acesulfame, aspartame, cyclamates, maltitol, saccharin, sucralose, taumatine, neosperidine, steviol glycosides, neotame, acesulfame-aspartame salt, isomalt, lactitol, xylitol, erythritol, tecnosweet N3 (flavouring premixes combining high intensity natural sweeteners and sensory additives. It is a blend of natural extracts and polyols to increase sweetening power and the relative palatability commercially available by Tecnessenze s.r.l. Ca de Fabbri Minerbio Bologna Italy).
  • Proteins such as meat, meat extracts, milk powder, fish meat, chicken meat, fish extracts, sea food, sea food extracts, yeast, yeast extract and the like.
  • Fruits such as apple, apricot, banana, blackberry, cherry, currant, gooseberry, grapefruit, raspberry, strawberry (pure, syrup or extract).
  • Fats and oils such as vegetable oils from e.g. corn, olive, caraway, peanut, sesame oil, soy bean, sunflower, palm, wheat germ, animal derived fats and fish derived oils and the like.
  • Attractants may also include biscuit powder and the like and coconut pulp flour, coconut flakes.
  • Attractants which further may be mentioned by way of example are natural and artificial flavours such as liquorice flavour, banana flavour, peanut butter flavour, coconut flavour, onion flavour, milk flavour, butter flavour, cheese flavour, melon flavour, hazelnut flavour, cream flavour, brioche flavour, biscuit flavour, caramel flavour, vanilla flavour, cereal flavour, chocolate flavour, peach flavour, black cherry flavour, berries flavour, strawberry flavour, raspberry flavour, and poultry flavours, beef marrow flavour, fish flavour, sea food flavour, yeast flavour and the like.
  • natural and artificial flavours such as liquorice flavour, banana flavour, peanut butter flavour, coconut flavour, onion flavour, milk flavour, butter flavour, cheese flavour, melon flavour, hazelnut flavour, cream flavour, brioche flavour, biscuit flavour, caramel flavour, vanilla flavour, cereal flavour, chocolate flavour, peach flavour, black cherry flavour, berries flavour, strawberry flavour, raspberry flavour, and poultry flavours, beef marrow flavour, fish flavour, sea food flavour, yeast flavour and the like.
  • the attractants can be used alone or as a mixture of two or more in any ratio.
  • attractants are soybean oil, starch, molasses, ice sugar, coconut pulp flour, coconut flavour or a mixture thereof.
  • attractants are corn starch, molasses, soybean oil, natural and artificial flavours, sweeteners or a mixture thereof.
  • attractants are corn starch, molasses, soybean oil or a mixture thereof. In a further embodiment of the invention attractants are corn starch, soybean oil or a mixture thereof.
  • Useful preservatives according to the invention include sorbic acid, potassium sorbate, calcium sorbate, acetic acid, potassium acetate, sodium acetate, calcium acetate, butylated hydroxytoluene (BHT).
  • BHT butylated hydroxytoluene
  • the rodenticide bait according to the invention further comprises a preservative selected from sorbic acid, potassium sorbate, calcium sorbate, acetic acid, potassium acetate, sodium acetate, calcium acetate, BHT or a mixture thereof.
  • a preservative selected from sorbic acid, potassium sorbate, calcium sorbate, acetic acid, potassium acetate, sodium acetate, calcium acetate, BHT or a mixture thereof.
  • Coloring agents according to the invention include curcumine, riboflavin (vitamin B12), cochineal (carminic acid), chlorophyll, caramel E 150 a-b-c-d, beta carotene (pro-vitamin A), lutein, canthaxanthin, antocyanins, lycopene, beetroot red (betanin).
  • Bitter agents include denatonium benzoate.
  • the rodenticide bait according to the invention further comprises a coloring selected from curcumine, riboflavin (vitamin B12), cochineal (carminic acid), chlorophyll, caramel E 150 a-b-c-d, beta carotene (pro-vitamin A), lutein, canthaxanthin, antocyanins, lycopene, beetroot red (betanin) or a mixture thereof.
  • a coloring selected from curcumine, riboflavin (vitamin B12), cochineal (carminic acid), chlorophyll, caramel E 150 a-b-c-d, beta carotene (pro-vitamin A), lutein, canthaxanthin, antocyanins, lycopene, beetroot red (betanin) or a mixture thereof.
  • Binder agents according to the invention include sodium lignosulfonate, carboxymethylcellulose, carboxyethylcellulose, or water.
  • water can be used during the pressing phase to improve the quality of pellet.
  • Glidant or lubricant agents according to the invention include calcium stearate, magnesium stearate, fumaric acid, glyceryl behenate, glyceryl palmitostearate or hydrogenated vegetable oil.
  • the rodenticide bait according to the invention further comprises a binder agent selected from lignosulfonate, carboxymethylcellulose, carboxyethylcellulose, or water or a mixture thereof.
  • the active ingredient is rise hulls, soybean hulls or a mixture thereof
  • the attractant is corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners such as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate or water or a mixture thereof and the preservative is BHT or sorbic acid.
  • the active ingredient is rise hulls, soybean hulls or a mixture thereof
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate or water or a mixture thereof
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 70 to 99% by weight of the bait composition
  • the active ingredient is rise hulls, soybean hulls or a mixture thereof
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate or water or a mixture thereof
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 80 to 99% by weight of the bait composition.
  • the active ingredient is rise hulls, soybean hulls or a mixture thereof
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate or water or a mixture thereof
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 90 to 99% by weight of the bait composition.
  • the active ingredient is soybean hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners such as saccharin, or a mixture thereof
  • the preservative is BHT or sorbic acid and the binder is sodium lignosulfonate and/or water.
  • the active ingredient is soybean hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 70 to 99% by weight of the bait composition.
  • the active ingredient is soybean hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 80 to 99% by weight of the bait composition.
  • the active ingredient is soybean hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 90 to 99% by weight of the bait composition.
  • the active ingredient is rise hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water and the preservative is BHT or sorbic acid.
  • the active ingredient is rise hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 70 to 99% by weight of the bait composition
  • the active ingredient is rise hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 80 to 99% by weight of the bait composition.
  • the active ingredient is rise hulls
  • the attractant is selected from corn starch, oat flour, molasses, powdered sugar, dextrose, soybean oil, corn oil, natural and artificial flavours such as yeast extract, fish extract, flake coconut, coconut flavour, or marrow flavour, sweeteners as saccharin, or a mixture thereof
  • the binder is sodium lignosulfonate and/or water
  • the preservative is BHT or sorbic acid and wherein the active ingredient is in an amount from 90 to 99% by weight of the bait composition
  • Examples of useful baits according to the invention include Cereals, Flaked Baits, Pellets, Paraffinized baits, Gel Baits, Fat Baits or Paste baits.
  • the bait is a Pellet bait.
  • the active ingredient is soybean hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are oat flour, corn oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT
  • the binder is water.
  • the active ingredient is soybean hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are oat flour, corn starch oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are oat flour, corn oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT
  • the binder is water.
  • the active ingredient is soybean hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, fish extract, the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, fish extract, the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT and the binder is water.
  • the active ingredient is soybean hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT
  • the binder is sodium lignosulfonate.
  • the active ingredient is soybean hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT
  • the binder is sodium lignosulfonate.
  • the active ingredient is soybean hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT
  • the binder is sodium lignosulfonate.
  • the active ingredient is rice hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are oat flour, corn oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT
  • the binder is water.
  • the active ingredient is rice hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are oat flour, corn oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT
  • the binder is water.
  • the active ingredient is rice hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are oat flour, corn oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT
  • the binder is water.
  • the active ingredient is rice hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, fish extract, the preservative is BHT and the binder is water.
  • the active ingredient is rice hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT and the binder is water.
  • the active ingredient is rice hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, fish extract
  • the preservative is BHT and the binder is water.
  • the active ingredient is rice hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT and the binder is water.
  • the active ingredient is rice hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT and the binder is water.
  • the active ingredient is rice hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT and the binder is water.
  • the active ingredient is rice hulls in an amount from 70 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT
  • the binder is sodium lignosulfonate.
  • the active ingredient is rice hulls in an amount from 80 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT
  • the binder is sodium lignosulfonate.
  • the active ingredient is rice hulls in an amount from 90 to 99% by weight of the bait composition
  • the attractants are corn starch, soybean oil, powdered sugar, dextrose, saccharin, coconut flakes, coconut flavour
  • the preservative is BHT
  • the binder is sodium lignosulfonate.
  • the baits according to the present invention can be used for controlling rodents, by placing them in locations where the rodents live, or through which they pass, either in the form of baits alone or by placing them into suitable containers.
  • the invention provides a method for controlling rodents characterized in that, an effective amount of composition is applied to an area in which the rodents are liable to be found.
  • This invention also relates to a process for the preparation of baits.
  • a process for producing a pellet bait comprises making composition comprising hulls of seeds or caryopses or a mixture thereof as active ingredients and attractants and adding, if required, a binder and or a glidant, then mixing all ingredients together to obtain a homogeneous dry and flowing powder, which is passed through an extruder to obtain pellets.
  • Example 1 preparation of a pellet bait for rodent control containing rice hull.
  • Step 1 preparation of rice hull pre-mix.
  • Rice hull was milled to obtain a fine and homogeneous flour.
  • Rice hull flour, molasses and soybean oil, in the amount as provided in Table 1 were mixed together for about 15 minutes in a mill to obtain a homogeneous, dry and flowing premix powder.
  • Step 2 preparation of powder to be pelletized
  • Cornstarch and sodium lignosulfonate according to quantities described in Table 1 , were added in a ribbon mixer together with the premix powder containing rice hull. The compound was mixed for 1 hour, to obtain a homogeneous, dry and flowing powder.
  • step 2 The powder of step 2 was passed through an extruder, to obtain pellets having a dimeter of 3 mm and length from 6 to 10 mm.
  • Table 1 provides the ingredients and function thereof in the pellet bait.
  • Example 2 preparation of a pellet bait for rodent control containing soybean hull.
  • Step 1 preparation of soybean hull pre-mix.
  • Soybean hull was milled to obtain a fine and homogeneous flour. Soybean hull flour, and soybean oil and molasses, in the amount as provided in Table 2, were mixed together for about 15 minutes in a mill to obtain a homogeneous, dry and flowing premix powder.
  • Step 2 preparation of powder to be pelletized
  • step 2 The powder of step 2 was passed through an extruder, to obtain pellets having a dimeter of 3 mm and length from 6 to 10 mm.
  • Table 2 provides the ingredients and function thereof in the pellet bait.
  • Soybean oil Attractant From 0.5 to 10
  • Example 3 preparation of a pellet bait for rodent control containing rice hull.
  • Step 1 preparation of rice hull pre-mix.
  • Rice hull was milled to obtain a fine and homogeneous flour. Rice hull flour, and corn oil, in the amount as provided in Table 3, were mixed together for about 15 minutes in a mill to obtain a homogeneous, dry and flowing premix powder.
  • Step 2 preparation of powder to be pelletized
  • step 2 passed through an extruder, to obtain pellets having a dimeter of 3 mm and length from 6 to 10 mm.
  • the compound can reach temperatures as high as 70-90°C, causing the evaporation of water which has been sprayed on top as a binder. This is not prejudicial to the good quality of the pellet.
  • Table 3 provides the ingredients and function thereof in the pellet bait.
  • test material consists of pellet prepared as described in Example 1 and Example 2.
  • Phase I Pre-test:one animal/cage.
  • Phase III Post-test observation: 3 or 5 animals/cage were put depending on the animal weight according to internal procedure.
  • the stabling rooms were lighted by fluorescent lamps and kept in alternate cycles of 12 hours' light and 12 hours' dark. Temperature and humidity were controlled by the air-conditioning plant and constantly monitored.
  • Watering the animals had free access to purified water supplied by an automatic watering system during the post test phase. During the phases of pre-test and test were made available daily 100 ml of water for each animal.
  • mice selected for the study were identified by means of indelible colour marks in different parts of the body.
  • the cages were identified with a tag.
  • Quarantine before the purchased animals were used for the trial, they were kept in quarantine for five days. During the quarantine, the animals were monitored every day. At the end of the quarantine, they were subjected to a thorough examination to verify their suitability for the trial. Selection of the animals: the animals used in the study were randomly selected among those suitable which were available at the time of the study.
  • mice were used divided into two groups, each of 5 animals, as shown in the tables below. 10 mice (5 male and 5 female) were used.
  • Phase I approximately 15 grams of the ground laboratory standard diet were inserted in a feeding dish centrally in each cage. 24 hours after every administration, the residual food was removed, weighed and completely replaced. The treatment was repeated for three consecutive days.
  • Phase II approximately 15 grams of test material were inserted into a feeding dish centrally in each cage. 24 hours after every administration, the remaining test material were removed, weighed and completely replaced. The treatment was repeated for eight consecutive days.
  • Phase III Post-test observation: 3 or 5 study animals/cage were put together depending on the animal weight according to internal procedure and feed with standard laboratory diet.
  • Clinical symptoms Phase II clinical symptom, including any change in somatomotor activities, were recorded twice daily. Clinical observations:
  • Phase III clinical symptom, including any change in somatomotor activities, were recorded daily. Clinical observations:
  • Rodenticide mortality evaluation percentage of mortality induced by the test substance. ( ⁇ 90% or ⁇ 90%)
  • Example 1 and Example 2 cause 100% MORTALITY for mouse.
  • Animal symptomatology observed consisted in piloerection, abdominal pain and depressed sensorium.
  • Symptomatology of male and female mice after administration of the bait of Example 1 are provided in Table 4 and Table 5 respectively.

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  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
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  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne un appât rodenticide destiné à la prévention et au traitement d'infestations par les espèces de rongeur comprenant des substances naturelles, telles que des coques de graines ou de caryopses ou un mélange de celles-ci en tant que principes actifs.
PCT/EP2018/079338 2017-10-26 2018-10-25 Appâts rodenticides WO2019081671A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035470A2 (fr) * 1996-03-27 1997-10-02 Delmar Products Ltd. Rodenticide
WO2002056693A1 (fr) * 2001-01-17 2002-07-25 Natrocell Technologies Ltd. Rodenticide et procede de criblage
EP1849358A1 (fr) * 2006-02-26 2007-10-31 Aleksej Yurevich Pokholkov Rodenticide
US8574638B1 (en) * 2012-04-06 2013-11-05 Stephen C. Perry Rodenticide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035470A2 (fr) * 1996-03-27 1997-10-02 Delmar Products Ltd. Rodenticide
WO2002056693A1 (fr) * 2001-01-17 2002-07-25 Natrocell Technologies Ltd. Rodenticide et procede de criblage
EP1849358A1 (fr) * 2006-02-26 2007-10-31 Aleksej Yurevich Pokholkov Rodenticide
US8574638B1 (en) * 2012-04-06 2013-11-05 Stephen C. Perry Rodenticide

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G JOKIC ET AL: "Alternative Methods to Chemical Control [PS7-1-6308]: Efficacy of a cellulose-based product in controlling house mouse (Mus musculus) in agricultural storage facilities", 9TH INTERNATIONAL WORKING CONFERENCE ON STORED PRODUCT PROTECTION, 18 October 2006 (2006-10-18), Campinas, São Paulo, Brazil, pages 677 - 680, XP055459098, ISBN: 978-85-6023-400-4 *
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