WO2019075974A1

WO2019075974A1 - Venous indwelling infusion device for animals

Info

Publication number: WO2019075974A1
Application number: PCT/CN2018/076926
Authority: WO
Inventors: 张绍东; 李菁; 王彬彬; 刘松; 王世炜; 万虹; 历俊华; 冯洁
Original assignee: 北京市神经外科研究所
Priority date: 2017-10-19
Filing date: 2018-02-20
Publication date: 2019-04-25
Also published as: CN107582209A

Abstract

A venous indwelling infusion device for laboratory animals. The infusion device is a tubular cavity structure having one end sealed and comprises a catheter (1), a connecting tube (2), and a sealing object (3). The device has a simple structure, can be implanted only by one operation, is easy to operate, and can achieve high success rate. A rat only needs to experience one operation with small injury. The whole device is completely under the skin, so that an animal subject to an operation is easy to manage and has few complications.

Description

Intravenous indwelling device for animals

Technical field

The present invention relates to medical devices, and more particularly to an intravenous infusion infusion device for laboratory animals, which is suitable for use in any laboratory animal, including but not limited to rabbits, dogs, rats, and the like.

Background technique

Experimental animal (rat) external jugular vein catheterization is widely used in animal experiments for intravenous drug injection or blood collection. Through literature search, it is found that although there are many changes in the structure of the catheter, the basic features and surgical operations are similar: the catheter is a deformation of a thin tube or a thin tube that is open at both ends. One end of the catheter is inserted into the external jugular vein, a section of the indwelling tube is inserted into the external jugular vein, and ligated and fixed; the other end of the catheter is guided through the skin, penetrated through the back of the neck of the animal, and is fixed to the muscle tissue and skin. on. The catheter is closed at the end of the extracorporeal end with a closure. When injecting the drug or drawing blood, the closure is opened, and the closure is returned after the operation is completed.

Taking rats as an example, the current rat external jugular vein catheterization requires two operations to complete.

The first operation was a rat external jugular vein cannulation: the rats were anesthetized, placed supine on the operating table, and the skin was cut beside the midline of the neck to expose the external jugular vein. The distal end of the external jugular vein was ligated and the lateral branch vein was burned. Make a hole in the vein and insert the prefilled heparin into the heart from the incision with an insertion depth of about 2.5 cm. The external jugular vein was ligated to fix the catheter, and the saline was pushed from the other end with a syringe to check that the tube was unobstructed.

The second operation consisted of placing the rat in a prone position, cutting a small opening in the skin behind the neck, guiding the free end of the catheter through the skin from the incision, and suturing it to the back muscle tissue and skin. Cut a suitable length of the catheter and close the nozzle.

By observing the above operations, it can be found that the prior art has the following disadvantages:

1. It is necessary to perform two operations on the animal, which takes a long time and causes great damage to the animal;

2. The catheter used is a PEG tube or an epidural catheter. It is relatively hard and has insufficient flexibility. It needs to be bent many times during intravascular and subcutaneous walking. The tension is very large, it is easy to pierce the blood vessel, or from the blood vessel. Prolapse, this situation is more likely to occur when the outer part of the back is subjected to a large external force or when an injection operation is performed;

3, the catheter exposed to the back of the neck is a foreign body to the animal, easy to cause the animal to scratch, easy to displace, fall off, animal wounds are also prone to infection;

4, in order to prevent animals from biting the catheter, it is necessary to raise the animals separately, increasing the cost of animal management;

5, the completion of surgery requires the surgeon to have quite skilled operation skills, the difficulty is higher.

Therefore, there is a need for an improved experimental animal (e.g., rat) with a jugular vein indwelling device.

Summary of the invention

It is an object of the present invention to provide a jugular vein indwelling device for experimental animals.

An experimental animal uses a vein (including but not limited to the external jugular vein) to retain an infusion device, the infusion device being a tubular cavity structure closed at one end, comprising:

a catheter, which is a straight tubular structure or a curved tubular structure, having a first portion insertable into the external jugular vein and a second portion connectable to the connecting tube;

a connecting tube, which is a tubular structure having different diameters at both ends, the end of the connecting tube having a smaller diameter of the nozzle communicating with the second portion of the conduit;

a closure, the closure being disposed at an end of the connecting tube having a larger diameter to close the nozzle, and the closure is permeable.

Further, the conduit is a curved tubular structure with an included angle between the first portion and the second portion. This structure is more suitable for rats. Preferably, the conduit is an L-shaped tubular structure.

The outer diameter of the catheter is such that it can be inserted into the vein. Further, the length of the catheter is such that a portion is still extravascularly after insertion into the vein of 2-2.5 cm. Preferably, the length of the catheter is greater than 3 cm.

Further, the catheter is provided with a scale for indicating the length. Preferably, the conduit is provided with a graduation for marking the length from the nozzle at its first portion. More preferably, the catheter has tick marks at 1 cm, 2 cm, 3 cm from the mouth of the first portion thereof.

Further, the diameter of the nozzle of the connecting pipe is gradually increased from the smaller end to the larger diameter end.

The closure is a component having a sealing function and a penetrable function, such as a latex cap, a silicone cap or a rubber stopper or the like.

The invention has the following advantages:

The intravenous indwelling device for experimental animals of the present invention solves many shortcomings of the prior art, and can realize long-term intravenous infusion treatment of animals; the whole device is composed of only three parts, and the structure is simple; the insertion can be completed only by one operation. The operation is simple and the success rate is high; the animal only needs one operation and the injury is small; the whole device is completely under the skin, and the postoperative animal management is simple and the complications are few.

DRAWINGS

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing the structure of a venous indwelling device for an experimental animal of the present invention.

Fig. 2 is a schematic view showing the structure of a preferred embodiment of the intravenous indwelling device for laboratory animals of the present invention.

Detailed ways

Example

As shown in Fig. 1, it is a schematic structural view of a venous indwelling device for an experimental animal of the present invention. The device is a tubular structure closed at one end, comprising a catheter 1, a connecting tube 2 and a silicone cap 3.

The catheter 1 is a straight tubular structure having a first portion 11 insertable into the vein and a second portion 12 connectable to the connecting tube. The outer diameter of the catheter 1 is such that it can be inserted into the vein with an overall length greater than 3 cm. On the first portion 11, there are graduation marks 4 at 1 cm, 2 cm, and 3 cm from the verbal end of the tube.

The connecting pipe 2 is a tubular structure having a first nozzle 21 and a second nozzle 22, and the diameter of the nozzle from the first nozzle 21 to the second nozzle 22 is gradually increased. The first nozzle 21 is connected to the second portion 12 of the conduit 1 in part. The inner diameter of the connecting tube 2 is larger than the outer diameter of the catheter 1 to reduce the difficulty of puncture.

The silicone cap 3 is placed over the second nozzle 22 of the connecting tube 2 for closing the venous indwelling tube and serving as a venipuncture for the intravenous injection. The silicone cap 3 can be replaced with an emulsion cap, a rubber stopper or the like.

As shown in Figure 2, in a preferred embodiment, the catheter 1 is an L-shaped curved tubular structure that is more suitable for use in rats.

The specific operation process of the intravenous infusion infusion device is now described as follows:

1. Prepare the required intravenous infusion device, inject heparin saline from the silicone cap 3, fill the intravenous infusion device, and set aside.

2. The rats were anesthetized and placed in a supine position. The skin was cut in the right side of the midline of the neck, the fascia was separated, the external jugular vein was exposed, the distal end of the external jugular vein was ligated, and the lateral branch vein supplying blood to the external jugular vein was burned. The proximal end of the external jugular vein was ligated with a silk thread, and two knots were loosely pre-released. Use a micro-shear to cut the mouth on the vein, the size of which can be placed in the catheter 1. The catheter 1 is accurately inserted into the external jugular vein, and the blood vessel and the catheter 1 are fixed with a reserved knot. Open the knot of the ligature vein and dip the catheter 1 slightly into the blood vessel.

3. Change the posture of the rat to the lateral position, extend the surgical forceps from the neck incision to the dorsal side of the neck, and separate the skin and muscles of the neck of the rat. After obtaining sufficient space, the connecting tube 2 is fed from the incision. In the subcutaneous space, the position of the indwelling infusion device was adjusted, and the catheter 1 was inserted into the proximal end of the vein to a depth of 2-2.5 cm, and the connecting tube 2 was adjusted to be in an upright state behind the rat ear. Stitch the neck skin. The rat's neck is passed through the skin and penetrated through the silicone cap 3 for injection. If the operation is normal, the injection should be smooth.

The series of detailed descriptions set forth above are merely illustrative of the possible embodiments of the invention, which are not intended to limit the scope of the invention, and many other modifications and embodiments can be devised by those skilled in the art. These modifications and implementations are intended to fall within the scope and spirit of the principles disclosed herein. More specifically, various variations and modifications can be made in the component parts and/or arrangement of the subject combination arrangement within the scope of the disclosure, the drawings and the claims. Other uses will be apparent to those skilled in the art, in addition to variations and modifications in the component parts and/or arrangements.

Claims

An intravenous infusion infusion device for an experimental animal, characterized in that the infusion device is a tubular cavity structure closed at one end, comprising:

a catheter, which is a straight tubular structure or a curved tubular structure, having a first portion insertable into the external jugular vein and a second portion connectable to the connecting tube;

a connecting tube, which is a tubular structure having different diameters at both ends, the end of the connecting tube having a smaller diameter of the nozzle communicating with the second portion of the conduit;

a closure, the closure being disposed at an end of the connecting tube having a larger diameter to close the nozzle, and the closure is permeable.
A venous indwelling device for an experimental animal according to claim 1, wherein said catheter is a curved tubular structure having an angle between said first portion and said second portion.
The intravenous indwelling device for an experimental animal according to claim 2, wherein the catheter is an L-shaped tubular structure.
A venous indwelling device for an experimental animal according to claim 1, wherein the length of the catheter is such that a portion is still outside the blood vessel after being inserted into the external jugular vein by 2-2.5 cm.
A venous indwelling device for an experimental animal according to claim 1 or 2, wherein the catheter is provided with a scale for indicating the length.
A venous indwelling device for an experimental animal according to claim 5, wherein said catheter is provided with a scale for indicating the length from the nozzle at the first portion thereof.
A venous indwelling device for an experimental animal according to claim 6, wherein said catheter has a scale mark at 1 cm, 2 cm, and 3 cm from the nozzle portion in the first portion thereof.
A venous indwelling device for an experimental animal according to claim 1 or 2, wherein the diameter of the nozzle of the connecting tube is gradually increased from the end having the smaller diameter to the end having the larger diameter.
The intravenous infusion and infusion device for laboratory animals according to claim 1 or 2, wherein the closure is a latex cap, a silicone cap or a rubber stopper.
A rat external jugular vein indwelling device, characterized in that the infusion device is a tubular cavity structure closed at one end, comprising:

a catheter having a curved tubular structure having a first portion insertable into the external jugular vein and a second portion connectable to the connecting tube, the two portions having an included angle therebetween;

a connecting tube, which is a tubular structure having different diameters at both ends, the end of the connecting tube having a smaller diameter of the nozzle communicating with the second portion of the conduit;

a closure, the closure being disposed at an end of the connecting tube having a larger diameter to close the nozzle, and the closure is permeable.