WO2019062366A1 - Prothèse de valve cardiaque - Google Patents

Prothèse de valve cardiaque Download PDF

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Publication number
WO2019062366A1
WO2019062366A1 PCT/CN2018/100645 CN2018100645W WO2019062366A1 WO 2019062366 A1 WO2019062366 A1 WO 2019062366A1 CN 2018100645 W CN2018100645 W CN 2018100645W WO 2019062366 A1 WO2019062366 A1 WO 2019062366A1
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WO
WIPO (PCT)
Prior art keywords
heart valve
valve prosthesis
stent body
arm
leaflet
Prior art date
Application number
PCT/CN2018/100645
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English (en)
Chinese (zh)
Inventor
刘明
阳明
陈国明
李�雨
Original Assignee
上海微创心通医疗科技有限公司
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Publication of WO2019062366A1 publication Critical patent/WO2019062366A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body

Definitions

  • the present invention relates to the field of medical device technology, and in particular to a heart valve prosthesis.
  • Aortic regurgitation refers to the flow of blood that has flowed into the aorta back to the left ventricle due to a loosely closed aortic valve during diastole. Mild to moderate aortic regurgitation may have no significant symptoms, and patients with moderate to severe aortic regurgitation may experience a cardiac compensatory period, with an average survival of only 2 to 5 years after loss of compensation.
  • TAVR valves Most of the existing TAVR valves are fixed by stent self-expansion (represented by Medtronic Core-Valve) or balloon-expandable stent (represented by Edwards Sapien), and the stent is fixed with calcified leaflets and annulus; In patients, after the stent itself expands, the calcified leaflets or annulus can hold the stent firmly, and the fixation is achieved by the calcified tissue and the radial support of the stent. From the anatomical features of aortic regurgitation, the primary valve leaf and the aortic root are often not necessarily accompanied by severe calcification, which is flexible, so the traditional TAVR valve cannot be fixed by radial support force.
  • TAVR valves radial support force fixation
  • the overall effect is not good, the valve is prone to ventricular turbulence, such as Medtronic Core-Valve, DFM , Lotus.
  • TAVR valves for the treatment of aortic regurgitation have become an industry challenge.
  • J-Valve uses the same concept, except that its clips are The valve body is not integral. All of them use transapical implantation, which has a disadvantage of being traumatic compared with the traditional TAVR valve transfemoral implantation.
  • the Edwards HELIO+XT system is based on the original Edwards Sapien-XT valve prosthesis, adding a rigid clamp (HELIO), the clamp is placed in the aortic sinus, and then the Sapien-XT valve is faked. Body release, clamps and valves clamp the native leaflets for fixation.
  • the prior art also discloses the treatment of aortic valve regurgitation by means of a transfemoral implant clamp and a transapical implanted Sapien-XT valve. It is expected that an implementation of simultaneous implantation of the clamp and the valve through the transfemoral approach may be proposed in the future. . It can be found that such a product system is complicated to operate and has high requirements for the operation of a doctor, and there are obvious deficiencies.
  • the mitral valve prosthesis is currently provided with a burr on the stent body, the valve is self-fixed by puncturing the leaflet, but for the aortic valve, the method of puncturing the leaflet is easy. Puncture the wall of the sinus, causing a risk of internal bleeding.
  • the mitral valve prosthesis is fixed by the lobular prosthesis. Can not be simply transplanted to the aortic annulus.
  • the present invention provides a heart valve prosthesis for replacing a pro-aortic valve located between an aorta and a ventricle, the pro-aortic valve including a native valve leaf, the heart
  • the valve prosthesis includes a stent body, a prosthetic leaflet fixed to the stent body, and at least one convex structure disposed on a sidewall of the stent body, wherein:
  • the at least one convex structure is configured to climb over the upper edge of the native leaflet.
  • the stent body is a mesh column structure
  • the pro-aortic valve further comprises an aortic annulus
  • the stent body comprises a first segment, the first region The segment is adapted to abut against the aortic annulus.
  • each of the protruding structures includes at least one arm structure, the arm structure includes a fixed end and a free end, and the fixed end is connected to the bracket body, The arm structure is configured to climb over the upper edge of the native leaflet.
  • each of the convex structures includes two of the arm structures
  • the free ends of the two arm structures are connected to each other
  • the arm structure forms a closed grid unit with the bracket body.
  • each of the convex structures further includes an anti-scratch structure, the anti-scratch structure is located at a free end of the arm structure for preventing the The arm structure stabs the blood vessels.
  • the anti-scratch structure is a straight rod or a curved rod, and is integrally formed with the arm structure.
  • the anti-scratch structure is a disc-shaped, spherical or curved rod-like structure connected to the arm structure.
  • the ratio of the length of the arm structure to the diameter of the stent body is 5% to 25%.
  • the distance from the fixed end of the arm structure to the root of the first section is 10 mm to 15 mm.
  • the heart valve prosthesis further comprises a skirt structure, the skirt structure is stitched on the inner wall of the bracket body, and the artificial leaflet is located near the first One side of a section.
  • the convex structure can be restrained in the mesh of the mesh column structure when the stent body is in a contracted state.
  • an angle between each of the convex structures and the axis of the stent body is 5° to 175°.
  • the material of the stent body is nickel titanium alloy.
  • the artificial leaflet comprises three single leaves, and the three single leaves are prepared by the anti-calcification treatment of the pig pericardium material, and are stitched or bonded.
  • the method is fixed on the bracket body.
  • the prosthetic leaflets when blood flows from the aorta to the ventricle, the prosthetic leaflets are closed, and the outer prosthetic structure is used to climb the upper edge of the native leaflets, and the native valve can be made
  • the leaf bears against the convex structure, which counteracts the pressure exerted by the returning blood on the artificial leaflet, prevents the stent body from pulsing toward the ventricle, and effectively achieves self-fixation, and has a better fixation effect.
  • the stent body and the convex structure of the present invention are small in size, and are suitable for a variety of transcatheter implantation such as transfemoral implantation, which has small trauma and simple operation.
  • the invention combines the radial supporting force of the stent body, can effectively solve the anchoring problem of the heart valve prosthesis at the root of the aorta, and achieve stable implantation of the stent body.
  • FIG. 1 is a schematic front elevational view of a heart valve prosthesis according to an embodiment of the present invention
  • FIG. 2 is a schematic top plan view of a heart valve prosthesis according to an embodiment of the present invention.
  • FIG. 3 is a schematic front elevational view of a heart valve prosthesis and an aorta according to an embodiment of the present invention
  • FIG. 4 is a top plan view of the heart valve prosthesis and the aorta according to an embodiment of the present invention
  • Figure 5 is a schematic front elevational view of a heart valve prosthesis according to another embodiment of the present invention.
  • FIG. 6 is a schematic top plan view of a heart valve prosthesis according to another embodiment of the present invention.
  • FIG. 7 is a schematic front elevational view of a heart valve prosthesis with an anti-scratch structure according to an embodiment of the present invention.
  • Figure 8 is a schematic view of the heart valve prosthesis of the embodiment of the present invention assembled in a sheath tube;
  • the figure shows: 1-stent body; 2-prosthetic leaflet; 3-convex structure; 31-arm structure; 32-scratch-resistant structure; 4-skirt structure; 5--prosthetic leaflet; Arterial annulus; 7-Valella sinus; 8-aorta; 9-sheath; 10-auxiliary unit.
  • the inventors of the present application have found that the use of a conventional valve that relies on radial support force for the treatment of aortic regurgitation has problems such as unstable anchoring and easy turbulence, and cannot achieve a good therapeutic effect.
  • the structure of the valve leaflets is clamped by the clip, and the overall size of the valve is large, and it needs to be implanted through the apex.
  • the trauma is larger, which is not conducive to the postoperative recovery of the elderly patients.
  • the use of the apex method to implant the clamp and the valve in succession in addition to the traumatic disadvantage of the transfemoral, is complicated to operate and requires high doctors.
  • the fixation of the mitral valve prosthesis with the leaflets creates a risk of internal bleeding.
  • the core idea of the present invention is to provide a heart valve prosthesis capable of effectively solving the anchoring problem of the interventional artificial heart valve prosthesis in the release position without significant calcification in the aortic root; and the prosthesis can be
  • the transfemoral implantation enables the heart valve prosthesis to be easily released, and can effectively improve the operation time and postoperative recovery time, so as to achieve self-fixation when treating aortic regurgitation, and the trauma is small and the operation is simple.
  • the present invention provides a heart valve prosthesis, in particular a heart valve prosthesis suitable for preventing prosthetic agitation when the aortic blood is returned to the ventricle.
  • the stent body of the valve prosthesis is designed with a convex structure, which can effectively fix the valve prosthesis and realize the expected function of the valve prosthesis.
  • the present invention provides a heart valve prosthesis for replacing a primary aortic valve between an aorta and a ventricle, the primary aortic valve including a native valve leaflet
  • the heart valve prosthesis includes a stent body 1 , a prosthetic leaflet 2 fixed to the stent body 1 , and a convex structure 3 disposed on a sidewall of the stent body 1 , wherein the prosthetic leaflet 2 is used Opened when blood flows from the ventricle to the aorta, and closed when blood flows from the aorta to the ventricle; the convex structure 3 is used to climb over the upper edge of the native leaflet.
  • the stent body 1 is a mesh column structure formed by a plurality of stent rods, and the mesh column structure includes a plurality of meshes.
  • the hole is defined by a stent rod, and the connection point between the stent rods is defined as a node of the columnar structure, and the mesh is formed by a node connection, and the primary aortic valve further includes an aortic annulus 6 and a sinus sinus 7
  • the native leaflet 5 extends from the aortic annulus 6, the length of the stent body 1 being greater than the distance from the aortic annulus 6 to the Watt's sinus 7, preferably greater than 10 mm to 15 mm, from the morphological structure
  • the stent body 1 includes a first section on the ventricular side, a transitional region and a second section on the aorta side along the longitudinal axis, and the convex structure may be disposed on the first section of the ventricular side, a transitional region and a second section
  • the stent body 1 After implantation of the prosthesis, the stent body 1 extends from the aortic annulus 6 to the sinus sinus 7 and further to the aorta 8, the stent body 1 having elasticity, The native leaflet 5 is pressed radially to the side of the sinus sinus 7 and the inner side of the native leaflet 5 is attached to the outside of the stent body 1.
  • the stent body 1 includes a first section, the first section (i.e., the inflow channel) for abutting against the aortic annulus 6 to provide a radial support force.
  • the prosthetic leaflet 2 is fixed to the inner side wall of the first section instead of the native leaflet 5, and the convex structure 3 is placed on the native leaflet 5.
  • each of the convex structures 3 includes at least one arm structure 31, and each of the arm structures 31 has a fixed end and freedom.
  • the fixed end of the arm structure 31 is connected to the bracket body 1, and the arm structure 31 is used to climb over the upper edge of the native leaflet 5, when blood flows back from the aorta 8 to the ventricle, The prosthetic leaflet 2 is closed and the native leaflet 5 bears against the arm structure 31 to counteract the pressure exerted by the returning blood on the prosthetic leaflet 2.
  • each of the convex structures 3 may include an arm structure 31 or a plurality of the arm structures 31, and each of the protrusions
  • the structure 3 includes a plurality of the arm structures 31, the free ends of the plurality of arm structures 31 are connected such that a plurality of the arm structures 31 form a closed grid unit with the bracket body, preferably
  • the arm structure 31 is two or two sets, and the two arm structures of each group form a U-shaped structure or a "V"-shaped structure after being connected at the free end.
  • 1 and 2 illustrate an embodiment of a convex structure including a first arm and a second arm, the fixed end of the first arm extending from a mesh node, And extending radially outward, the fixed end of the second arm protrudes from another mesh node and extends radially outward, and the first arm and the second arm intersect at the free end.
  • the first arm and the second arm are a straight rod or a curved rod.
  • the male structure including an arm structure 31 extending from the mesh of the bracket body 1 and radially Extend outside.
  • the arm structure 31 is a straight rod or a curved rod.
  • the convex structure 3 may further include an anti-scratch structure 32, which is located at the free end of the arm structure 31, and is connected to the arm structure 31.
  • the anti-scratch structure 32 is integrally formed with the arm structure 31, the anti-scratch structure 32 is a straight rod, the anti-scratch structure 32 extends toward the second section, and preferably,
  • the scraping structure 32 and the axis of the bracket body are parallel to each other, and the plurality of the protruding structures 3 may be arranged in a circumferentially uniform manner or may be arranged in a non-uniform manner.
  • the anti-scratch structure 32 extends in the direction of the second segment, and may also be 0-60° from the axis of the stent body 1.
  • the scratch-resistant structure 32 can also be a curved rod, and the tangent to the end point of the curved rod is 0 to 60°, preferably 30° to the axis of the stent body 1.
  • the anti-scratch structure 32 may be a disc-shaped, spherical or curved rod-like structure, and the arm structure 31 is connected by welding or the like.
  • the anti-scratch structures may be used for Any of the above-mentioned convex structures is not limited in the present invention.
  • the ratio of the length of the arm structure 31 to the diameter of the stent body 1 is 5% to 25%.
  • the vertical distance from the fixed end of the arm structure 31 to the root of the first section ie, the bottom end of the bracket body 1 in the perspective of FIG. 7) is 10 mm to 15 mm, which can well adapt to the height of the native leaflets.
  • the climbing structure of the convex structure 3 and the upper edge of the original leaflet 5 is realized.
  • the number of the convex structures 3 is plural, and the arm structures 31 included in all the convex structures are located in the same body of the bracket body 1.
  • the plurality of arm structures 31 are evenly or unevenly distributed, preferably, the plurality of arm structures 31 are evenly distributed on the cross section of the bracket body 1, and the cross section is to the main
  • the distance of the annulus 6 is 10 mm to 15 mm, which is slightly higher than the upper edge of the native leaflet 5.
  • the angle between the arm structure 31 and the axis of the bracket body 1 is 5° to 175°, that is, the angle of the eversion of the arm structure 31 is any angle of 5 to 90°, preferably 45°, 60°, 90°, in addition, the arm structure 31 can be everted outwardly toward the ventricle or outwardly toward the aorta, and the fixed end of the arm structure 31 is radially outward from the node of the stent body. Extending and extending toward the first segment or extending toward the second segment.
  • the material of the stent body 1 is nickel-titanium alloy, which has material memory function, and also has good elasticity, can prevent deformation of the stent body caused by blood pressure, and is preferably cut and fabricated by using nickel-titanium superelastic tube, through heat treatment, polishing, etc. After the process, it is formed into the unfolded form shown in the figure. Due to the shape memory characteristics of the nickel-titanium alloy, the stent body 1 has a self-expanding property, a contracted form of transport and a released form of release. As shown in Fig. 2, the artificial leaflets 2 are fixed on the stent body 1, mainly distributed on the first section.
  • the prosthetic leaflet comprises three or more single leaves (single-leaf valve), and the three single leaves are prepared from the calcified porcine pericardium material and fixed by suture or bonding.
  • the bracket body 1 is described.
  • the heart valve prosthesis further includes a skirt structure 4, the skirt structure 4 is sewn on the inner side wall of the bracket body 1, and is located at the The prosthetic leaflet 2 is adjacent to one side of the first section to prevent leakage of the valve.
  • the skirt structure 4 may be prepared from a homologous or heterologous biological material, or may be prepared from a synthetic material such as polyethylene terephthalate (PET).
  • the convex structures 3 extend from the nodes between the grids of the stent body 1. Therefore, when the stent body 1 is compressed into a contracted configuration, the above-mentioned convex structure 3 can be restrained in the space defined by the mesh unit, and the outer shape of the contracted body 1 is not significantly enlarged, and can be transported to the release position via the strand. .
  • the convex structure 3 is turned outward, and the contour diameter formed by the plurality of convex structures 3 around the bracket body 1 is increased compared to the contour diameter of the first section of the bracket body 1.
  • the profile diameter of the convex structure 3 is 10% to 50% larger than the diameter of the first segment in the unfolded state.
  • Figure 8 illustrates the contracted configuration of the stent body in a transport state.
  • the stent body 1 further has an auxiliary unit 10 near one end of the aorta. As shown in FIG. 8, the auxiliary unit 10 is used for combining and fixing the stent body 1 with the guiding rod in the sheath 9 to make the sheath 9
  • the heart valve prosthesis is delivered through the femoral artery into the blood vessel.
  • the stent body 1 is self-expanding and has a contracted configuration for delivery and a deployed configuration for release.
  • the heart valve prosthesis of the present invention is provided with a convex structure, which can be mounted on the upper edge of the native leaflet in the deployed state, and can effectively solve the anchoring problem of the valve prosthesis in the release position under the condition of no calcification of the aortic root.
  • the convex structure of the present invention can be restrained in the mesh shape of the mesh column structure in the contracted state, and the outer shape of the contraction shape is not significantly increased, and can be released through the femoral artery and released at the root of the aorta, compared with the transapical involvement. , small trauma, effectively improve postoperative recovery time.
  • the protruding structure of the present invention can be used to climb the upper edge of the native leaflet without adjusting the azimuth angle of the stent body, and the stent body release operation is simple, and the operation time can be effectively improved.
  • the above embodiments describe the different configurations of the heart valve prosthesis in detail.
  • the present invention includes, but is not limited to, the configurations listed in the above embodiments, and any of the configurations provided by the above embodiments are performed.
  • the contents of the transformation are all within the scope of protection of the present invention. Those skilled in the art can make the same according to the content of the above embodiments.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne une prothèse de valve cardiaque, la prothèse de valve cardiaque étant utilisée pour remplacer une valve aortique d'origine localisée entre l'aorte et un ventricule ; la valve aortique d'origine comprend des feuillets natifs, et la prothèse de valve cardiaque comprend un corps d'endoprothèse (1), des feuillets artificiels (2) qui sont fixés sur le corps d'endoprothèse (1), et des structures convexes externes (3) qui sont disposées sur une paroi latérale du corps d'endoprothèse (1), les structures convexes externes (3) étant utilisées pour saisir un bord supérieur d'un feuillet natif. À l'aide des structures convexes externes (3) saisissant un bord supérieur d'un feuillet natif, le feuillet natif peut venir en butée contre les structures convexes externes (3) afin de contrebalancer la pression qui est exercée par le sang de retour sur les feuillets artificiels (2), empêchant le corps d'endoprothèse (1) de se déplacer vers le ventricule, atteignant de manière efficace l'autofixation ; en outre, le corps d'endoprothèse (1) et la structure convexe externe (3) étant de petite taille, convient à l'implantation transfémorale, provoquant peu de traumatismes dans la mesure alors que l'opération est simple.
PCT/CN2018/100645 2017-09-29 2018-08-15 Prothèse de valve cardiaque WO2019062366A1 (fr)

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CN201710909340.X 2017-09-29
CN201710909340.XA CN109567985A (zh) 2017-09-29 2017-09-29 心脏瓣膜假体

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Cited By (4)

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US11471282B2 (en) 2019-03-19 2022-10-18 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US11672657B2 (en) 2018-10-05 2023-06-13 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US11833034B2 (en) 2016-01-13 2023-12-05 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12053371B2 (en) 2020-08-31 2024-08-06 Shifamed Holdings, Llc Prosthetic valve delivery system

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CN110074899A (zh) * 2019-04-08 2019-08-02 北京佰仁医疗科技股份有限公司 一种用于介入瓣中瓣的支架
CN212996889U (zh) * 2020-07-17 2021-04-20 宁波健世生物科技有限公司 一种带定位件的瓣膜假体及其输送系统
CN113995554A (zh) * 2020-07-28 2022-02-01 北京迈迪顶峰医疗科技有限公司 人工瓣膜
CN114469446A (zh) * 2020-11-13 2022-05-13 上海微创心通医疗科技有限公司 瓣膜支架和瓣膜假体
CN113893066B (zh) * 2021-11-02 2024-08-23 环心医疗科技(苏州)有限公司 一种防反流人工心脏瓣膜

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