WO2019037659A1

WO2019037659A1 - Integrated carbon fiber composite artificial bone and preparation method thereof

Info

Publication number: WO2019037659A1
Application number: PCT/CN2018/101008
Authority: WO
Inventors: 谭周建; 易旭
Original assignee: 湖南碳康生物科技有限公司
Priority date: 2017-08-23
Filing date: 2018-08-17
Publication date: 2019-02-28
Also published as: CN107536659A; CN107536659B

Abstract

An integrated carbon fiber composite artificial bone and preparation method thereof, the artificial bone comprising a carbon fiber composite spring-shaped frame main body and a carbon fiber composite pin member provided at one end or two ends thereof. The preparation method comprises: using carbon fiber as raw material, performing a knitting process to prepare a spring-shaped carbon fiber pre-fab, then by means of densification, high-temperature purification and preparation of a wear-resistant coating layer, obtaining the carbon fiber composite artificial bone. The artificial bone is light, has good biocompatibility and good mechanical performance, and particularly has high elastic deformability and favorable toughness, and can realize the function and curved shape of a soft bone portion, thus having high practical utility.

Description

Integrated carbon fiber composite material artificial bone and preparation method thereof

Technical field

The invention relates to an artificial bone, in particular to an integrated carbon fiber composite artificial bone and a method for preparing carbon fiber composite artificial bone by using carbon fiber weaving technology and profiling technology, and belongs to the field of biomedical materials.

Background technique

Trauma, tumors, infections, and bone defects caused by dysplasia have always been a problem for medical scientists. Artificial bone grafting is a common method for treating clinical bone defects. At present, the artificial bone biomaterials used in the field of orthopedics mainly include metal materials, ceramics, and polymer materials, and there are many reports in this field. A porous ceramic artificial bone material formed of β-calcium phosphate, which can be implanted into bone marrow cells, has a good compatibility, as disclosed in Japanese Patent Application No. CN02807099.2. Chinese Patent (Application No. CN201510928718.1) discloses a porous artificial bone having a honeycomb grid shape and a preparation method thereof, and mainly prepares a MgSr-TCP honeycomb grid by using an existing 3D printing method for raw materials such as PLGA and MgSr-TCP. The frame, the PLGA slurry and the nano-sized sodium chloride particles are mixed and oscillated, poured into the honeycomb grid frame, freeze-dried and dried to obtain artificial bone. The artificial bone has better hardness and toughness and good biomechanics. Different shapes of frames can be designed to meet individual needs, and more flexible and intelligent. Chinese Patent (Application No. CN200810227420.8) discloses the preparation of a medical metal artificial bone trabeculae, which is mainly used to melt a titanium alloy powder at a high temperature by an electron beam melting device to form a metal artificial bone trabeculae, and its mechanics and The biological characteristics are similar to human bones, the surface friction coefficient is high, the structure is stable, and the application range is wide. It is suitable for the substitute bones of various bone defects, bone filling, bone support, bone reconstruction and bone shaping in the human skeletal system. All of the artificial bone implants currently reported have their own advantages, but there are also some obvious shortcomings. For example, metal materials are easy to electrolyze, easy to wear, easy to fatigue, easy to loose, easy to corrode, bone absorption, medical imaging has artifacts, etc.; polymer materials have aging, poor creep resistance, toxicity, thrombosis, etc. Insufficient, and bioceramic materials have the disadvantages of no plasticity, brittleness, and easy breakage.

Carbon materials have good biocompatibility, among which carbon fiber, pyrolytic carbon, carbon nanotubes and their composites are used in heart valves, bones, tendons, growth stents, oncology drugs, biosensors, and the like. In particular, the carbon/carbon composite material in which the carbon material is a matrix, the carbon fiber and the fabric thereof are reinforcing bodies has light weight, good biocompatibility, good chemical stability, mechanical properties similar to human bones, and good fatigue resistance. The design is strong and is regarded as an ideal replacement material for the existing artificial bone, which is pursued by the developers. At present, more carbon materials have been used for artificial bone. For example, the Chinese patent (CN201110324420.1) discloses that the intermediate layer structure uses high-strength carbon fiber. To strengthen the hardness and toughness, the carbon fiber is pre-impregnated with a phenolic resin into a composite reinforcing material; the carbon fiber outer layer is formed by a vapor phase deposition method on the surface of the carbon fiber to form a silicon carbide layer. The epoxy resin is adhered to the outer layer of silicon carbide in the direction of carbon fiber stretching to form an epoxy resin layer, the outer layer of the epoxy resin layer is plasma-sprayed to form a HA layer, and the outer layer of the HA layer is provided with an OPG protein layer, and the artificial bone has high strength. Good hardness, good toughness, corrosion resistance, high bearing capacity, good tissue compatibility, firmness and good shape. The Chinese patent (CN201210261732.7) discloses a method for preparing a personalized carbon-carbon composite artificial bone, selecting a carbon fiber reinforced carbon matrix as a raw material, and performing artificial bone contouring by CT image acquisition, and converting the collected artificial bone contour into Non-uniform rational B-spline surface method is used to treat carbon fiber reinforced carbon matrix to form carbon/carbon composite artificial bone structure, and then argon gas is introduced into vacuum glow discharge chamber to carry out carbon/carbon composite artificial bone surface. After plasma pretreatment, a hydroxyapatite coating was sprayed on the surface to prepare a personalized carbon/carbon composite artificial bone.

technical problem

Although these carbon/carbon composite materials have the characteristics of light weight, good biocompatibility, good chemical stability, and similar mechanical properties to human bones, they cannot achieve elastic deformation, and cannot realize some functions of cartilage and bending modeling, etc. Its scope of application.

Technical solution

In view of the defects of artificial bone prepared by the existing carbon/carbon composite material, an object of the present invention is to provide a light weight, good biocompatibility, good mechanical properties, no artifacts in medical images, and particularly high elasticity. Deformation and good toughness, integrated carbon fiber composite artificial bone that can realize partial cartilage function and bending shape.

Another object of the present invention is to provide a method for preparing an integrated carbon fiber composite artificial bone having high elastic deformation and good toughness, and capable of realizing partial cartilage function and bending shape by using a carbon fiber weaving technique and a profiling technique. The method is simple and easy to operate, and is advantageous for mass production.

In order to achieve the above technical object, the present invention provides an integrated carbon fiber composite artificial bone, comprising a carbon fiber composite spring-like skeleton body and a carbon fiber composite material pin disposed at one or both ends thereof.

Preferably, the integrated carbon fiber composite artificial bone comprises a spring-like skeleton integrated structure with one or both ends and a pin-shaped piece woven from carbon fiber, and a pyrolytic carbon coating, a silicon carbide coating or a heat on the surface thereof. Carbon/silicon carbide hybrid coating. Preparation of pyrolytic carbon, silicon carbide or pyrolytic carbon/silicon carbide hybrid coating on the surface of carbon fiber material to form carbon fiber composite material, mainly to modify the surface of carbon fiber, such as improving its wear resistance and increasing its biocompatibility. .

The integrated carbon fiber composite artificial bone proposed by the invention has a special carbon fiber composite spring-like skeleton, and the spring-shaped skeleton formed by the carbon fiber composite material imparts good elastic deformation property to the artificial bone, can be bent at any 360°, and the carbon fiber composite material pin As the connecting end of the artificial bone and other tissues, it is advantageous for the fixation of the artificial bone, and the artificial bone having the structure can realize the partial function and the curved shape of the cartilage. Moreover, the artificial bone of the invention has an integrated structure and has an integrated structure, which can reduce the joint position, is convenient to use, and reduces the difficulty of implantation.

In a preferred embodiment, the carbon fiber composite spring-shaped skeleton body is provided with a carbon material sleeve outside. Since the artificial bone is implanted into the human body, the tissue will grow into the spring-like skeleton portion of the artificial bone, thereby affecting the deformation thereof, and the casing action can effectively prevent the occurrence of this situation. The setting of the carbon material sleeve affects the bending deformation performance of the spring-like skeleton portion of the artificial bone, but the telescopic deformation performance can be ensured, and the diameter of the carbon material sleeve is slightly larger than that of the carbon fiber composite spring-like skeleton to ensure the carbon fiber composite. The material spring-like skeleton still has a certain bending deformation performance, which satisfies the practical application requirements.

In a preferred embodiment, the carbon fiber composite pin is provided with a plurality of suture holes. The suture hole is mainly used for fixing the artificial bone during the transplantation process.

Preferably, the carbon fiber composite spring-like skeleton body has a circular, elliptical, D-shaped, pea-shaped or square cross section.

Preferably, the integrated carbon fiber composite artificial bone has a bulk density of 0.8 g/cm ³ to 2.0 g/cm ³ . The integrated carbon fiber composite artificial bone has the characteristics of light weight.

The invention provides a preparation method of an integrated carbon fiber composite artificial bone, which comprises the following steps:

1) Screwing a plurality of carbon fibers into a carbon fiber rope, and then weaving at least three carbon fiber ropes into carbon fiber strands, one end or middle portion of the carbon fiber strands being wound in parallel in a clockwise or counterclockwise direction on a rod mold to form a spring-like carbon fiber preform body;

2) after the spring-like carbon fiber preform is densified by chemical vapor infiltration and/or liquid impregnation, the carbon fiber spring-like skeleton body is obtained;

3) the carbon fiber spring-like skeleton blank is removed from the rod-shaped mold, placed in a vacuum or a protective atmosphere, and purified at a high temperature to obtain a carbon fiber spring-like skeleton;

Alternatively, the carbon fiber spring-like skeleton body is placed in a vacuum or a protective atmosphere, and after high-temperature purification, the rod-shaped mold is removed to obtain a carbon fiber spring-like skeleton;

4) preparing a pyrolytic carbon coating, a silicon carbide coating or a pyrolytic carbon/silicon carbide mixed coating on the surface of the tubular skeleton to obtain an artificial bone; or, inserting a carbon material outside the spring-like skeleton of the carbon fiber composite material of the artificial bone Socket.

In a preferred embodiment, the integrated carbon fiber composite artificial bone preparation process of the present invention comprises mechanically punching a carbon fiber crucible as a pin in any step of steps 1) to 4) as a suture hole.

Preferably, the carbon fiber rope is screwed from at least 1 k carbon fiber, and k represents one thousand.

The preferred solution is to first weave a carbon fiber crucible with A carbon fiber rope, then reduce the number of carbon fiber rope to B, continue to weave a piece of carbon fiber crucible, then increase the number of carbon fiber rope to A root, continue to weave a piece of carbon fiber crucible, and obtain a thick middle end. Fine carbon fiber 辫I; or, first weave a carbon fiber 辫 with A carbon fiber rope, then reduce the number of carbon fiber rope to B, continue to weave a piece of carbon fiber 辫, obtain a carbon fiber 辫 II with one end and a thin end; the carbon fiber 辫I Or the thinner end or the thinner portion of the carbon fiber crucible II is wound in parallel in a clockwise or counterclockwise direction on the rod-shaped mold to form a spring-like carbon fiber preform; wherein B≥3, AB≥1. In the technical solution of the present invention, the pin piece is mainly used as the connecting end of the artificial bone and the tissue. In order to ensure the mechanical properties of the pin piece, the carbon fiber can be made by increasing the number of carbon fiber ropes at one or both ends of the carbon fiber raft during the process of weaving the carbon fiber raft. After the end of the crucible is thickened, the fiber portion is made into a spring-like carbon fiber preform, and the pin portion is thickened. Moreover, the lengths of the carbon fiber bundles for the braided pin and the braided spring-like skeleton structure can be arbitrarily adjusted according to actual conditions.

Preferably, the rod-shaped mold is composed of a carbon material or a material capable of forming a carbon material at a high temperature. The choice of carbon material in the mold ensures that the carbon fiber material does not deform or collapse during subsequent carbonization.

Preferably, the rod-shaped mold has a circular, elliptical, D-shaped, pea-shaped or square cross section. The size and shape of the mold cross section can be arbitrarily adjusted according to actual conditions.

Preferably, the temperature of the high temperature treatment is 1200 ° C ~ 2600 ° C, and the holding time is 2 h ~ 15 h.

In a preferred embodiment, the braided spring-like skeleton portion of the carbon fiber braided spring-like carbon fiber preform may be woven with a single carbon fiber strand or a plurality of carbon fiber strands. Moreover, the degree of weaving density of carbon fiber 辫 can be adjusted according to actual conditions.

The carbon fibers of the present invention are polyacrylonitrile-based carbon fibers or are viscose-based, pitch-based, and phenol-based carbon fibers.

The chemical vapor infiltration process of the invention: the spring-shaped carbon fiber preform is placed in a vacuum furnace, and the carbonaceous gas source (natural gas, methane or propylene, etc.) which is introduced at a temperature of 800 ° C to 1300 ° C is subjected to cracking, chemical vapor phase Deposited in a spring-like carbon fiber preform, after 50 to 300 hours, a carbon fiber spring-like skeleton body is prepared.

The liquid impregnation densification process of the present invention: the carbon fiber spring preform is passed through a resin (furan, phenolic and

Densification process such as ketone, etc. or asphalt (graphite pitch, coal pitch) vacuum pressure impregnation, solidification treatment, carbonization (resin: 1000 ° C, atmospheric pressure; asphalt: 800 ° C, 100 MPa). The immersion pressure is 1.0~5.0MPa, the immersion time is 2~10 hours, the curing temperature is 160~230°C, the curing time is 10~50 hours, and the carbonization time is 2~20 hours.

The pyrolytic carbon coating of the present invention is prepared by: 1) carbon source gas, natural gas, methane or propylene, etc.; 2) deposition temperature, 900 to 1300 ° C; 3) deposition time, 10 to 100 hours.

The silicon carbide coating of the present invention is prepared by: 1) a raw material, trichloromethylsilane and hydrogen; 2) a deposition temperature of 900 to 1200 ° C; and 3) a deposition time of 10 to 120 hours.

The pyrolytic carbon/silicon carbide hybrid coating of the present invention is prepared by preparing a pyrolytic carbon coating and then preparing a silicon carbide coating as described above.

Beneficial effect

Compared with the prior art, the technical solutions of the present invention bring about beneficial technical effects:

1) The integrated carbon fiber composite artificial bone of the invention is composed of carbon/carbon composite material, and the carbon/carbon composite material has good biocompatibility, light weight, mechanical property close to human bone, good fatigue resistance and designability. Strong, medical images without artifacts.

2) The integrated carbon fiber composite artificial bone of the invention has a special structure, and has a special "spring-like" skeleton and a braided pin with good mechanical properties, and the spring-like skeleton gives the artificial bone good elastic deformation performance, 360° arbitrarily bent, and the carbon fiber pin is used as the connecting end of the artificial bone and other tissues, which is beneficial to the fixation of the artificial bone, and the artificial bone having the structure can realize part of the function and bending shape of the cartilage. The carbon fiber composite artificial bone can further be provided with a carbon material sleeve to prevent the artificial bone from being implanted into the human body, and the tissue grows into the spring-like skeleton portion of the artificial bone, thereby affecting the deformation ability.

3) The artificial bone of the invention has an integrated structure and has an integrated structure, which can reduce the joint position, is convenient to use, and reduces the difficulty of implantation.

4) The carbon fiber composite material skeleton of the present invention is woven by carbon fiber, first screwed into a carbon fiber rope, and then woven into a carbon fiber crucible, and finally made of a spring-like carbon fiber preform from carbon fiber crucible, and the prepared spring-like structure not only maintains the carbon fiber itself. It has light weight, good mechanical properties, good toughness, and good elastic deformation performance similar to spring. The prepared artificial bone spring joint has a tensile rigidity coefficient of 0.1~5kg/mm, an elongation of 10~100%, and a bending deformation angle. 0 to 360°, while the conventional carbon/carbon composite is a block and cannot be elastically deformed.

5) The integrated carbon fiber composite artificial bone of the invention is combined with the carbon fiber weaving technology and the profiling technology, and the method is simple in operation and easy to be processed, and is favorable for mass production.

DRAWINGS

1 is a photograph of a carbon fiber composite artificial bone prepared in Example 1, a is an artificial bone having pin pieces at both ends and the pin pieces are not perforated, b is an artificial bone provided with pin holes at both ends, and a sleeve is provided ;

2 is a photograph of the carbon fiber composite artificial bone prepared in Example 2 (the pin piece is provided at one end, and the pin piece is not perforated).

Embodiments of the invention

The following examples are intended to further illustrate the invention and are not intended to limit the scope of the invention.

Example 1

1) First twist 12k polyacrylonitrile-based carbon fiber into a carbon fiber rope, then weave 5 12k carbon fiber rope into a piece of carbon fiber 辫 (about 20mm), reduce the number of carbon fiber rope, and weave a carbon fiber with 3 carbon fiber ropes. Then, the amount of carbon fiber is increased, and a carbon fiber strand (about 20 mm) is woven with 5 carbon fiber ropes to obtain a carbon fiber crucible having a thick and fine intermediate carbon fiber crucible, and the carbon fiber crucible is wound in a clockwise parallel tight section in the middle. A spring-shaped carbon fiber preform is formed on a carbon material mold having a rectangular shape (the same size as the human ribs), and the length of the entire preform is similar to the length of the artificial rib. The thicker section of the carbon fiber crucible is mechanically perforated as a suture hole.

2) the tubular carbon fiber preform is placed in a natural gas atmosphere, chemical vapor deposition at a temperature of 1100 ° C for 200 hours, a green body density of 1.2 g / cm ³ , that is, a carbon fiber spring-like skeleton body;

3) the carbon fiber spring-like skeleton blank is removed from the rod-shaped mold, placed in an argon atmosphere, heated to 2200 ° C, and the holding time is 10 h, to carry out the impurity removal treatment, that is, a carbon fiber spring-like skeleton;

4) The carbon fiber spring-like skeleton uses methane as a carbon source, and is chemically vapor deposited at a temperature of 1150 ° C for 50 hours to prepare a pyrolytic carbon coating, which is an artificial rib.

In the artificial rib prepared in this embodiment, the tensile rigidity coefficient of the spring-like skeleton is 0.2 kg/mm, the elongation is 60%, and the maximum deformation angle is 180°.

The spring-like skeleton is bent at an angle of 8° after the carbon material sleeve is inserted outside the artificial rib.

Example 2

1) Screw 12k polyacrylonitrile-based carbon fiber and 6k polyacrylonitrile-based carbon fiber into carbon fiber rope, 1 12k polyacrylonitrile-based carbon fiber rope and 4 6k polyacrylonitrile-based carbon fiber ropes to braid a piece of carbon fiber 辫 (about 20mm) Then, a 12k polyacrylonitrile-based carbon fiber rope and two 6k carbon steel fibers are twisted into one carbon fiber, and the finer ends of the carbon fiber crucible are wound in a clockwise parallel and tightly wound on a carbon material mold having a D-shaped cross section (section size). Similar to the human ribs, a spring-like carbon fiber preform is formed, and the length of the entire preform is similar to the length of the artificial rib. The thicker section of the carbon fiber crucible is mechanically perforated as a suture hole.

2) The carbon fiber spring-like carbon fiber preform is made of phenolic resin as impregnating agent, and subjected to vacuum pressure impregnation, solidification treatment, carbonization and other densification processes. The main parameters are: impregnation pressure 3.0 MPa, time 5 hours; curing at 200 ° C 20 Hour; carbonized at atmospheric pressure for 4 hours at 1000 °C. After 3 cycles, the density of the green body is 1.5 g/cm ³ ; that is, a carbon fiber spring-like skeleton body is obtained;

3) the carbon fiber spring-like skeleton blank is removed from the rod-shaped mold, placed in an argon atmosphere, heated to 2000 ° C, and the holding time is 12 h, to carry out the impurity removal treatment, that is, a carbon fiber spring-like skeleton;

4) The carbon fiber spring-like skeleton is made of trichloromethylsilane and hydrogen as raw materials, and chemical vapor deposition time is carried out at a temperature of 1100 ° C for 30 hours to prepare a silicon carbide coating on the surface of the carbon fiber spring-like skeleton.

Artificial ribs.

In the artificial rib prepared in this embodiment, the tensile rigidity coefficient of the spring-like skeleton is 1 kg/mm, the elongation is 40%, and the maximum deformation angle is 60°.

Example 3

1) Screw three 3k polyacrylonitrile-based carbon fibers into carbon fiber ropes, then weave five carbon fiber ropes into carbon fiber strands, and twist one end of three carbon fiber strands in a counter-clockwise parallel winding on a carbon material mold with a rectangular cross section. (The cross-section is similar to the human ribs), forming a spring-like carbon fiber preform, the length of the entire preform is similar to the length of the artificial rib. The thicker section of the carbon fiber crucible is mechanically perforated as a suture hole.

2) The tubular carbon fiber preform first uses propylene as a carbon source and nitrogen as a diluent gas, and the chemical vapor deposition time is 120 hours at a temperature of 900 °C. Then, the phenolic resin is used as the impregnating agent, and the densification process such as vacuum pressure impregnation, solidification treatment, carbonization, etc., the main parameters are: impregnation pressure 4.0 MPa, time 3 hours; curing at 220 ° C for 15 hours; at 950 ° C temperature , carbonization at atmospheric pressure for 6 hours, liquid phase immersion for 2 cycles, preparation of a bulk density of 1.8 g / cm ³ , that is, a carbon fiber spring-like skeleton blank;

3) the carbon fiber spring-like skeleton blank is removed from the rod-shaped mold, placed in an argon atmosphere, heated to 2100 ° C, and the holding time is 10 h to perform the impurity removal treatment, thereby obtaining a carbon fiber spring-like skeleton;

4) Using methane as a carbon source on the surface of the tubular skeleton, chemical vapor deposition at a temperature of 1120 ° C for 30 hours, then using trichloromethylsilane and hydrogen as raw materials, chemical vapor deposition time at a temperature of 1100 ° C for 20 hours . Preparation of pyrolytic carbon and silicon carbide composite coating, that is, artificial ribs.

In the artificial rib prepared in this embodiment, the tensile rigidity coefficient of the spring-like skeleton is 4 kg/mm, the elongation is 20%, and the maximum deformation angle is 30°.

Claims

An integrated carbon fiber composite artificial bone, comprising: a carbon fiber composite spring-like skeleton body and a carbon fiber composite material pin disposed at one end or both ends thereof.
The integrated carbon fiber composite artificial bone according to claim 1, wherein the integrated carbon fiber composite artificial bone comprises a spring-like skeleton integrated structure in which one end or both ends are woven by carbon fiber and pin pieces are provided. A pyrolytic carbon coating, a silicon carbide coating or a pyrolytic carbon/silicon carbide hybrid coating on the surface.
The integrated carbon fiber composite artificial bone according to claim 1, wherein:

The carbon fiber composite spring-shaped skeleton body is provided with a carbon material sleeve outside;

The carbon fiber composite pin has a plurality of suture holes.
The integrated carbon fiber composite artificial bone according to claim 1 or 3, wherein the carbon fiber composite spring-like skeleton body has a circular, elliptical, D-shaped, pea-shaped or square cross section.
The integrated carbon fiber composite artificial bone according to claim 1, 2 or 3, wherein the integrated carbon fiber composite artificial bone has a bulk density of 0.8 g/cm 3 to 2.0 g/cm 3 .
The method for preparing an integrated carbon fiber composite artificial bone according to any one of claims 1 to 5, comprising the steps of:

1) Screwing a plurality of carbon fibers into a carbon fiber rope, and then weaving at least three carbon fiber ropes into carbon fiber strands, one end or middle portion of the carbon fiber strands being wound in parallel in a clockwise or counterclockwise direction on a rod mold to form a spring-like carbon fiber preform body;

2) after the spring-like carbon fiber preform is densified by chemical vapor infiltration and/or liquid impregnation, the carbon fiber spring-like skeleton body is obtained;

3) the carbon fiber spring-like skeleton blank is removed from the rod-shaped mold, placed in a vacuum or a protective atmosphere, and purified at a high temperature to obtain a carbon fiber spring-like skeleton;

Alternatively, the carbon fiber spring-like skeleton body is placed in a vacuum or a protective atmosphere, and after the high-temperature purification treatment, the rod-shaped mold is removed to obtain a carbon fiber spring-like skeleton;

4) preparing a pyrolytic carbon coating, a silicon carbide coating or a pyrolytic carbon/silicon carbide mixed coating on the surface of the tubular skeleton to obtain an artificial bone; or, inserting a carbon material outside the spring-like skeleton of the carbon fiber composite material of the artificial bone Socket.
The method for preparing a carbon fiber composite artificial bone according to claim 6, wherein the carbon fiber rope is screwed from at least 1 k carbon fiber, and k represents one thousand.
The method for preparing a carbon fiber composite artificial bone according to claim 6, wherein:

Firstly weave a piece of carbon fiber reinforced with A carbon fiber rope, then reduce the number of carbon fiber rope to B, continue to weave a piece of carbon fiber 辫, then increase the number of carbon fiber rope to A, continue to weave a piece of carbon fiber 辫, and get the carbon fiber 粗 at the ends. I; or, firstly weave a carbon fiber crucible with A carbon fiber rope, then reduce the number of carbon fiber rope to B, continue to weave a piece of carbon fiber crucible, obtain a carbon fiber crucible II with one end and a thin end; and the carbon fiber crucible I or carbon fiber crucible II The thinner end or the thinner portion in the middle is wound in a clockwise or counterclockwise direction on the rod mold to form a spring-like carbon fiber preform; wherein B≥3, AB≥1.
The method for preparing a carbon fiber composite artificial bone according to claim 6, wherein the rod-shaped mold is made of a carbon material or a material capable of forming a carbon material at a high temperature;

The rod-shaped mold has a circular, elliptical, D-shaped, pea-shaped or square cross section.
The method for preparing a carbon fiber composite artificial bone according to any one of claims 6 to 9, wherein the temperature of the high temperature treatment is 1200 ° C to 2600 ° C, and the heat preservation time is 2 h to 15 h.