WO2019013499A2 - Cosmetic composition for defending against blue light - Google Patents

Abstract

A cosmetic composition for defending against blue light comprises Carthamus tinctorius (safflower) seed oil as an active ingredient and reduces the passage of blue light having a wavelength of 400-500 nm.

Description

Blue light protective cosmetic composition

A blue light protective cosmetic composition is provided.

With the increasing use of electronic devices such as smart phones, laptops, computers and TVs in everyday life, modern people are increasingly exposed to blue light generated by electronic devices. For example, in a typical office worker, the average daily exposure to natural light including ultraviolet rays is about 0.9 hours, and the average daily exposure to blue light from electronic devices is about 10.2 hours . This is very different from the days when there was little exposure to blue light in the past and exposure to natural light, and it is becoming more important to defend the blue light.

Blue light is a blue light with a wavelength of about 400-500 nm, and it has high energy and is sometimes called HEV (High-Energy Visible) light. Blue light penetrates into the skin like ultraviolet rays, causing oxidation reaction, and has cytotoxicity. Because UVB penetrates down to the epidermis and UVA penetrates into the dermis, the blue light may be more harmful to the skin than ultraviolet light, because the blue light penetrates deeper into the subcutaneous layer than the dermis.

The present inventors can apply the blue light protective cosmetic composition to cosmetics for which the blue light protection function has not been applied for the first time, thereby enabling the user to positively cope with skin troubles due to environmental problems.

One embodiment of the present invention is to reduce skin damage by blocking the blue light to reduce the amount of active oxygen generated to suppress the inflammatory reaction.

One embodiment of the present invention is for blocking ultraviolet rays with blue light.

One embodiment of the present invention is to minimize irritation reactions such as itching, rash, redness, swelling of the chemical blocker.

And can be used to achieve other tasks not specifically mentioned other than the above tasks.

A cosmetic composition for protecting blue light according to one embodiment of the present invention is a cosmetic composition which protects blue light or protects skin from blue light.

The blue light protective cosmetic composition contains a natural or natural origin component, and accordingly, the skin irritation reaction such as itching, eye rash, redness, swelling and the like caused by the use of cosmetics containing conventional chemical blocking agents Can be minimized.

The blue light protective cosmetic composition contains carthamus tinctorius (safflower) seed oil as an active ingredient and reduces the passage of blue light at a wavelength of about 400 nm to about 500 nm.

The blue light protective cosmetic composition may further comprise a tagetes erecta flower extract as an active ingredient.

The blue light protective cosmetic composition may further contain a broccoli extract which is a natural or natural-derived ingredient.

The blue light protective cosmetic composition may further comprise a black or white extract and a rice extract which are natural or natural derived ingredients.

The blue light protective cosmetic composition may be a natural or naturally occurring component and may further comprise an ultraviolet screening material to reduce the passage of ultraviolet radiation at a wavelength of from about 280 nm to about 400 nm.

One embodiment of the present invention can block blue light to reduce the amount of active oxygen generated, thereby suppressing the inflammatory reaction and preventing skin damage.

One embodiment of the present invention may block ultraviolet radiation with blue light.

One embodiment of the present invention can minimize skin irritation reactions such as itching, rash, redness, swelling and the like caused by conventional chemical blockers, including natural or natural derived ingredients.

FIG. 1 is a blue light cutoff experimental drawing.

2 is a graph showing the amount of active oxygen when blue light is exposed to human epidermal keratinocytes (HEK).

3 is a graph showing the amount of active oxygen when blue light is exposed to human dermal fibroblast (HDF).

4 is a graph showing cell viability when irradiated with blue light to epidermal keratinocytes.

5 is a graph showing cell activity when blue light is irradiated to dermal fibroblasts.

6 is a graph showing a blue light transmission spectrum measured using a tone 28 HEV SCREEN.

Figure 7 is a graph showing the blue light protection factor and the percentage of sunlight blocked in the tone 28 HEV SCREEN.

BRIEF DESCRIPTION OF THE DRAWINGS The above and other features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and the same reference numerals are used for the same or similar components throughout the specification. In the case of publicly known technologies, a detailed description thereof will be omitted.

Throughout the specification, when an element is referred to as " comprising ", it means that it can include other elements as well, without excluding other elements unless specifically stated otherwise.

Throughout the specification, the term "natural or naturally derived component" means a component existing in nature or extracted from a natural product.

Throughout the specification, the term " extract " means a substance in which a substance containing an active ingredient is separated from a raw material using a solvent such as alcohol, acetone, acetate, chloroform or glycol.

Throughout the specification, " active ingredient " means a material having an effective amount to such an extent that it can exhibit a particular effect.

All of the ingredients contained in the blue light protective cosmetic composition are natural or natural derived ingredients, so that the cosmetic composition can be environmentally friendly and skin troubles can be reduced. For example, skin irritation reactions such as itching of the skin, scorching of the eyes, redness of the skin, and swelling may be reduced.

Furthermore, the blue light protective cosmetic composition contains about 60% or more organic components, so that the cosmetic composition can be more environmentally friendly and skin troubles can be minimized. For example, skin irritation reactions such as itching of the skin, burning of the eyes, redness of the skin, and swelling may be minimized.

The blue light protective cosmetic composition may comprise a tagetes erecta flower extract. Flower extracts of ThyssenKrupp can reduce the passage of blue light with natural or naturally derived components. The blue light may have a wavelength of from about 400 nm to about 500 nm. The flowering flower extract may be used in an amount of 0.005 to 2% by weight based on the whole cosmetic composition.

The blue light protective cosmetic composition may comprise carthamus tinctorius (safflower) seed oil. The safflower seed oil may be a natural or naturally derived component and may reduce the passage of blue light. The safflower seed oil may be used in an amount of about 0.005 to 2% by weight based on the total cosmetic composition.

The blue light protective cosmetic composition may contain both a flower of Thalassa and a safflower seed oil. In this case, the synergy of the two components may further reduce the passage of blue light.

The blue light protective cosmetic composition may comprise a natural or natural sunscreen material. The ultraviolet screening material may reduce the passage of ultraviolet radiation at a wavelength of from about 280 nm to about 400 nm. For example, the ultraviolet screening material may comprise zinc oxide from natural sources. Zinc oxide may be used in an amount of about 20-30% by weight based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise a natural or natural-derived conditioning agent. Conditioning agents may be used instead of purified water. For example, the conditioning agent may include a broccoli extract (brassica oleracea italica (broccoli) extract). Broccoli extracts have a higher antioxidant capacity than purified water alone and can help dry skin. The broccoli extract may be a natural or naturally derived component, an organic component and may be used in an amount of about 40-65% by weight based on the total cosmetic composition. For example, the conditioning agent may comprise a black soybean extract (Glycine Soja (Soybean) Seed Extract). Black soybean extract can help balance sebum and oil in oily skin. The black soybean extract may be a natural or naturally derived ingredient, an organic ingredient, and may be used in an amount of about 40-65% by weight based on the total cosmetic composition. In addition, the conditioning agent may comprise a rice extract (Oryza Sativa (Rice) Extract). Rice extracts can help balance sebum and oil in oily skin. The rice extract may be a natural or naturally derived component, an organic component, and may be used in an amount of about 5-20% by weight based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise a natural or natural derived softening agent. The softening agent can soften the keratin skin and increase the moisture retention of the skin. For example, the softening agent may comprise vitis vinifera (grape) seed oil. The grape seed oil may be a natural or natural derived component, an organic component, and may be used in an amount of about 1-10% by weight based on the whole cosmetic composition. For example, the softening agent may comprise olive oil (olea europaea (olive) fruit oil). Olive oil is similar to oil in the skin, so when olive oil is used on dry skin, it can change the skin's germination more smoothly and increase the moisture retention. Olive oil may be a natural or naturally occurring component, an organic component, and may be used in an amount of about 1-5% by weight based on the total cosmetic composition. For example, the softening agent may comprise coco-caprylate / caprate. The coco-caprylate / caprate may be used as 1-10% by weight of the total cosmetic composition as a natural or naturally derived ingredient. When coco-caprylate / caprate is used in combination with grape seed oil, skin softening can be further promoted.

The blue light protective cosmetic composition may comprise an emulsifying agent of natural or natural origin. For example, the emulsifier may be a surfactant. The emulsifier may comprise sorbitan olivate. The sorbitan olivate may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition. The emulsifier may include isostearic acid. The isostearic acid may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition. The emulsifier may comprise cetyl alcohol. The cetyl alcohol may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise emulsifying stabilizers of natural or naturally occurring ingredients. The emulsion stabilizer can stabilize the formed emulsion. For example, the emulsion stabilizer may include cetearyl alcohol. The cetearyl alcohol may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise a suspending agent of natural or natural origin. Suspending agents can help disperse solids in the cosmetic composition and induce smooth mixing. For example, the suspending agent may comprise polyhydroxyl stearic acid. The polyhydroxystearic acid may be used in an amount of about 0.005 to 2% by weight based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise a natural or natural moisture blocking agent. Moisture blocking agents can maintain moisturization of the skin. For example, the water vapor barrier may be avocado butter (persea gratissima (avocado) butter). Avocado butter can be a natural or naturally derived ingredient, an organic ingredient, and can be used in an amount of about 0.005 to 2% by weight based on the total cosmetic composition. For example, the water vapor barrier may include mango seed butter. Mango seed butter may be a natural or naturally derived component, an organic component, and may be used in an amount of from about 0.005% to about 2% by weight of the total cosmetic composition. For example, the water vapor barrier may comprise polyglyceryl-2-dipolyhydroxystearate. For example, polyglyceryl-2-dipolyhydroxy stearate may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise waxes of natural or naturally occurring ingredients. The wax can inhibit moisture evaporation and increase the viscosity of the composition. For example, the wax may comprise beeswax. For example, the beeswax may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise preservatives of natural or naturally occurring ingredients. For example, the preservative may include a golden extract (Scutellaria Baicalensis Root Extract), a cutellaria Baicalensis Root Extract, a Glycyrrhiza Extract, and the like. For example, the preservative may be used in an amount of about 0.005-3% by weight based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise a natural or naturally occurring component calamine. Calamin can reduce the oil emanating from the skin and can increase the makeup persistence. For example, the calamine may be used at about 1-5% by weight based on the total cosmetic composition.

The blue light protective cosmetic composition may comprise red iron oxide of a natural or naturally occurring component. Red iron oxide can correct skin tone. In the case of oily skin, sebum secretion and occurrence of acne may cause skin troubles, so that the skin tone of such skin can be corrected by red iron oxide. For example, the red iron oxide may be used in an amount of about 0.005-2 wt% based on the total cosmetic composition.

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples. However, the following Examples are merely examples of the present invention, but the present invention is not limited to the following Examples.

Example 1

Tone 28 HEV SCREEN, a cosmetic composition for blue light defense containing safflower seed oil and licorice extract, is prepared. Tone 28 HEV SCREEN contains about 1% by weight of the water extract, about 1% by weight of safflower oil, about 25% by weight of zinc oxide, about 54% by weight of organic broccoli extract, about 8% by weight of coco-caprylate / About 4% by weight of oil, about 4% by weight of organic olive oil, about 1% by weight of sorbitan olivate, about 1% by weight of organic avocado butter and about 1% by weight of polyglyceryl-2-dipolyhydroxystearate do.

Comparative Example 1

A cosmetic composition for comparison with Example 1 is prepared. The cosmetic composition comprises about 25% by weight of zinc oxide, about 56% by weight of organic broccoli extract, about 8% by weight of coco-caprylate / caprate, about 4% by weight of organic grape seed oil, about 4% by weight of organic olive oil, About 1% by weight of bait, about 1% by weight of organic avocado butter, and about 1% by weight of polyglyceryl-2-dipolyhydroxy stearate.

Blue light absorption

Blue light is irradiated for each of the tonne 28 HEV SCREEN prepared in Example 1 and each of the cosmetic compositions prepared in Comparative Example 1. As shown in the left side of FIG. 1, when a blue light is irradiated to a tone 28 HEV SCREEN using a device generating blue light, the blue light is absorbed by the tone 28 HEV SCREEN and is not passed.

On the other hand, as shown in the right side of FIG. 1, when the cosmetic composition prepared in Comparative Example 1 is irradiated with blue light, blue light is passed.

Active oxygen content of human epidermal keratinocytes (HEK)

The tone 28 HEV SCREEN prepared in Example 1 was administered to human epidermal keratinocytes at concentrations of 50 ppm, 100 ppm and 200 ppm, respectively, and then the blue light was irradiated and the blue light was irradiated without applying the tone 28 HEV SCREEN When examined, the amount of active oxygen of human epidermal keratinocytes is measured for each. The amount of active oxygen of epidermal keratinocytes in human is about 37 degrees Celsius when blue light is not irradiated.

The activity of reactive oxygen species (ROS) is measured using the Oxiselect ^™ Intracellular ROS Assay Kit. The activity of ROS is measured by measuring the relative fluorescence unit of free radicals such as hydroxyl group, peroxyl group, etc. present in the cell in response to the blue light exposure.

Referring to FIG. 2, when the blue light is exposed to human epidermal keratinocytes, the amount of active oxygen is increased about 4 times as compared with that when no exposure is performed. When using 28 ton HEV SCREEN, the amount of active oxygen is reduced by about 44-60% compared to the case without using 28 HEV SCREEN. As the amount of active oxygen generated decreases, inflammation reaction and skin damage can be prevented. In the graph of FIG. 2, the Y axis values are about 175, about 695, about 280, about 330, and about 390, respectively, in relative fluorescence (units).

Active oxygen content of human dermal fibroblast (HDF)

Tone 28 HEV SCREEN prepared in Example 1 was administered to human dermal fibroblasts at concentrations of 50 ppm, 100 ppm and 200 ppm, respectively, and the blue light was irradiated to the human dermal fibroblasts without the administration of the 28 HEV SCREEN The amount of active oxygen in the human dermal fibroblast is measured. The amount of active oxygen in human dermal fibroblasts is a reference value at about 37 degrees Celsius when the blue light is not irradiated.

Similar to the method described above, the activity of the ROS is measured using the Oxiselect ^™ Intracellular ROS Assay Kit.

Referring to FIG. 3, when the blue light is exposed to human dermal fibroblasts, the amount of active oxygen is increased about four times as compared with that when no exposure is observed. When using 28 ton HEV SCREEN, the amount of active oxygen is reduced by about 53-58% compared to the case without using 28 HEV SCREEN. As the amount of active oxygen generated decreases, inflammation reaction and skin damage can be prevented. In the graph of Fig. 3, the Y-axis values are Relative Fluorescence (units), in turn, about 190, about 800, about 340, about 370, about 380.

Cell activity of human epidermal keratinocytes

The tone 28 HEV SCREEN prepared in Example 1 was administered to human epidermal keratinocytes at concentrations of 50 ppm, 100 ppm and 200 ppm, respectively, and then the blue light was irradiated and the blue light was irradiated without applying the tone 28 HEV SCREEN When examined, the cell activity of human epidermal keratinocytes is measured for each. Cell activity of human epidermal keratinocytes at 37 degrees Celsius without blue light irradiation is a reference value.

The viability of active cells is measured using CellTiter 96 ^TM Aqueous One Solution Reagent (MTS) Assay.

Referring to FIG. 4, on the basis of the cell activity when human epidermal keratinocytes were not treated with any treatment, cell activity decreased when blue light was irradiated, and 50 HEV SCREEN of 50 ppm, 100 ppm, 200 When used in ppm, cell activity increases. In the graph of Fig. 4, the Y axis value is Cell Viability (%), which in turn is about 100, about 60, about 105, about 107, about 120.

Cell activity of human dermal fibroblasts

Tone 28 HEV SCREEN prepared in Example 1 was administered to human dermal fibroblasts at concentrations of 50 ppm, 100 ppm and 200 ppm, respectively, and the blue light was irradiated to the human dermal fibroblasts without the administration of the 28 HEV SCREEN The cellular activity of human dermal fibroblasts is measured. The cell activity of human dermal fibroblasts is a reference value at about 37 degrees Celsius when blue light is not irradiated.

Activity of active cells is measured using CellTiter 96 ^TM Aqueous One Solution Reagent (MTS) Assay.

Referring to FIG. 5, when the blue light was irradiated, the cell activity decreased and the tone 28 HEV SCREEN was reduced to 50 ppm, 100 ppm, and 200 ppm, respectively, based on the cell activity when no treatment was applied to human dermal fibroblasts When used, cell activity is increased. In the graph of FIG. 5, the Y-axis value is Cell Viability (%), which in turn is about 100, about 57, about 108, about 105,

Absorption of Blue Light by Formulation Thickness

Table 1 below shows the comparison of the tone 28 HEV SCREEN prepared in Example 1, the conventional UV screening agent and concealer, and conventional concealers against the blue light defenses. Conventional UV screening agents and concealers are Skin Protector ^TM and conventional concealers are Pro Longwear Concealer ^TM .

	Formulation Thickness 0.1mm or less	Formulation thickness 0.2 mm or less	Formulation thickness 0.4 mm
Ton 28 HEV SCREEN	O	O	O
Conventional UV screening and concealer	X	X	O
Conventional concealer	X	X	X

The average cosmetic thickness is 0.1-0.2 mm, and blue light is irradiated for 2 hours, 4 hours, and 6 hours to cosmetics of each thickness. When using a tone 28 HEV SCREEN, the blue light is defended irrespective of the thickness of the cosmetic formulation. Conventional UV screening agents and concealers protect the blue light when the formulation thickness is 0.4 mm, but not the blue light at lower thicknesses. Conventional concealers do not defend the blue light regardless of the thickness of the formulation.

Tone 28 Clinical Experiment of HEV SCREEN

Results of clinical trials on the tone 28 HEV SCREEN made in Example 1 in AMA Laboratories, a cosmetic clinical laboratory in New York, are shown in FIGS. 6 and 7. FIG.

6 is a graph showing a blue light transmission spectrum measured using a tone 28 HEV SCREEN. The X-axis is the wavelength (nm) and the Y-axis is the transmittance (%).

Referring to FIG. 6, the average% HEV protection is about 33.84%, the minimum% HEV protection is about 19.23%, the maximum% HEV protection ) Is about 88.07%.

Figure 7 is a graph showing the HEV light protection factor and% solar energy blocked of the tone 28 HEV SCREEN. The X-axis is the wavelength (nm) and the Y-axis is the spectral irradiance (%). The upper graph in FIG. 7 shows the spectral irradiance intensity of sunlight according to ISO 9845-1, and the lower graph shows the spectral irradiance intensity of sunlight passing through the tone 28 HEV SCREEN according to ISO 9845-1.

Referring to FIG. 7, the blue light protective factor is about 1.54 and the percentage of blocked solar cells (% SSl _HEV ) is about 35.1%.

6 and 7, the tone 28 HEV SCREEN effectively defends the blue light and the sunlight.

Example 2: Composition for dry skin

Thereby preparing a blue light protective cosmetic composition for dry skin. The cosmetic composition for dry skin blue light protection comprises about 1% by weight of a water extract, about 1% by weight of safflower seed oil, about 25% by weight of zinc oxide, about 50% by weight of organic broccoli extract, about 7% by weight of coco- About 3 wt% organic grape seed oil, about 3 wt% organic olive oil, about 3 wt% calamine, about 1 wt% sorbitan olivate, about 0.5 wt% isostearic acid, about 0.5 wt% cetyl alcohol, About 0.5 wt.% Of a tealyl alcohol, about 0.5 wt.% Of a polyhydroxystearic acid, about 0.5 wt.% Of an organic avocado butter, about 0.5 wt.% Of an organic mango seed butter, about 1 wt.% Of a polyglyceryl- About 0.5% by weight of beeswax, about 0.5% by weight of a golden extract, about 0.5% by weight of a peony root extract, and about 0.5% by weight of a licorice extract.

The dry skin composition prepared in Example 2, like the results of the experiment of Figs. 1 to 7 of Example 1, is protected against blue light and ultraviolet rays. As a result of using the dry skin composition prepared in Example 2 for dry skin, skin keratin was smoothly changed, moisturizing persistence was enhanced, and makeup persistence was increased, as compared with that used for oily skin.

Example 3: composition for oily skin

To prepare a blue light protective cosmetic composition for oily skin. The cosmetic composition for protecting against blue light for oily skin contains about 1% by weight of a water extract of Chrysanthemum, about 1% by weight of safflower seed oil, about 25% by weight of zinc oxide, about 40% by weight of organic black bean extract, about 10% by weight of organic rice extract, About 0.5% by weight of cetyl alcohol, about 3% by weight of an organic grape seed oil, about 3% by weight of an organic grape seed oil, about 1% by weight of sorbitan olivate, about 0.5% About 0.5 wt.% Of a tealyl alcohol, about 0.5 wt.% Polyhydroxystearic acid, about 0.5 wt.% Organic mango seed butter, about 1 wt.% Polyglyceryl-2-dipolyhydroxystearate, about 0.5 wt. About 0.5% by weight of a golden extract, about 0.5% by weight of a peony root extract, about 0.5% by weight of a licorice extract, and about 0.5% by weight of a red iron oxide.

The oily skin composition prepared in Example 3 defends against blue light and ultraviolet rays, as in the results of the experiment of Figs. 1 to 7 of Example 1. Fig. As a result of using the oily skin composition prepared in Example 3 for oily skin, the occurrence of sebum is reduced, the balance of the water content of the skin is maintained, the makeup duration is increased, and the skin tone correction is possible.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, And falls within the scope of the invention.

Claims (5)

1. Carthamus tinctorius (safflower) seed oil as an active ingredient,

   A cosmetic composition for protecting against blue light which reduces the passage of blue light at a wavelength of 400 nm to 500 nm.
2. The method of claim 1,

   A cosmetic composition for protecting against blue light, which further comprises a tagetes erecta flower extract as an active ingredient.
3. 3. The method of claim 2,

   A cosmetic composition for protecting blue light, which further comprises a broccoli extract which is a natural or natural-derived ingredient.
4. 3. The method of claim 2,

   A cosmetic composition for protecting blue light, which further comprises black bean extract and rice extract, which are natural or natural derived ingredients.
5. 3. The method of claim 2,

   A cosmetic composition for protecting blue light, which further comprises an ultraviolet shielding material which is a natural or natural derived component and which reduces the passage of ultraviolet rays at a wavelength of 280 nm to 400 nm.

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