WO2019009659A1 - Dispositif à micro-aiguilles - Google Patents

Dispositif à micro-aiguilles Download PDF

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Publication number
WO2019009659A1
WO2019009659A1 PCT/KR2018/007687 KR2018007687W WO2019009659A1 WO 2019009659 A1 WO2019009659 A1 WO 2019009659A1 KR 2018007687 W KR2018007687 W KR 2018007687W WO 2019009659 A1 WO2019009659 A1 WO 2019009659A1
Authority
WO
WIPO (PCT)
Prior art keywords
micro
skin
microneedle
drug
needles
Prior art date
Application number
PCT/KR2018/007687
Other languages
English (en)
Korean (ko)
Inventor
이윤석
Original Assignee
경상대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 경상대학교산학협력단 filed Critical 경상대학교산학협력단
Publication of WO2019009659A1 publication Critical patent/WO2019009659A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Definitions

  • the present invention relates to a microneedle device, and more particularly, to a microneedle device which is obliquely protruded obliquely from a surface of a microneedle plate.
  • the microneedle device is formed so as to be inclined in a rotating direction of the microneedle device, It is easy to use because the micro needle can penetrate the skin smoothly by applying force in the direction of rotation rather than applying to the skin, and the pain is less transmitted to the patient, so that the administration of the drug and the sampling of the biological sample such as blood are easy, To a shortened micro needle device.
  • Transdermal patches have long been used for the administration of small molecule type lipophilic drugs that can be easily absorbed through the skin.
  • This non-invasive delivery pathway is advantageous for the administration of many drugs that are incompatible with oral delivery because it allows for direct absorption of the drug into the systemic circulation system, thereby reducing the bioavailability of many drugs dramatically. Because it will bypass both portal vein systems.
  • Intradermal delivery also overcomes many of the difficulties associated with subcutaneous injection by greatly reducing the discomfort of the patient, the need for needles, the risk of accidental injury to the administering person, and the handling of sharp things.
  • transdermal delivery of drugs is limited to molecular classes that are compatible with absorption through the skin. Delivery of small molecule salt and therapeutic proteins is typically not feasible by conventional transdermal delivery since the skin provides an effective protective barrier for these molecules even in the presence of transdermal absorption enhancers.
  • Micro needle (including micro-blades) drug delivery devices have been proposed based on a wide variety of designs and materials. Some are solid, e.g., the drug is coated thereon; The other is that the hollow, e.g., the drug, is delivered from a reservoir. Some are made of metal, others are etched from a silicon material, and others are made of plastics, for example polycarbonate.
  • micro needles can vary considerably. Some have a single needle, while others, especially solid microneedles, have hundreds of needles per array. Most are in the range of 100 micrometers to 2 mm.
  • a skin permeation drug delivery method using a microneedle not only can control the amount and speed of delivery of a drug but also avoids the first passage of the drug in oral administration, and the bio drug with a high molecular weight such as a vaccine, a peptide, As shown in FIG.
  • the microneedle plate is obliquely formed in a slanting manner on one surface of the micro needle device.
  • the present invention provides a microneedle device which is permeable to the skin to administer a drug or to collect a biological sample of blood,
  • a microneedle formed on one surface of the microneedle device in a diagonal direction at a predetermined angle to be inserted directly into the skin and being inserted into the skin and allowing a drug to permeate or a biological sample of blood to be collected To a microneedle device.
  • microneedle device of the present invention is driven to the skin side while being rotated about the rotation axis so that the micronee needle can be easily transmitted to the skin, or is driven in the diagonal direction of the microneedle 20 to be transmitted to the skin. .
  • microneedles of the present invention are non-dissolving, dissolving, hollow, or porous.
  • the microneedles are formed to be spaced apart from each other, the microneedles being formed around the rotation axis of the plate on a plane, and being inclined in a direction of rotation of the microneedle device. .
  • the microneedles of the present invention are formed in a spiral shape about a rotation axis toward the center of the plate on the plane of the plate and are formed to be inclined in the rotation direction of the microneedle device To a microneedle device.
  • the inclination angle of the micro needle according to the present invention is 0 DEG & lt ;? & Lt; 90 DEG or 0 DEG & lt ;? ≪ 270 DEG.
  • the microneedle device of the present invention is formed by obliquely protruding obliquely from one side of the microneedle plate.
  • the microneedle device is inclined in the direction of rotation of the microneedle device, It is easy to use because the micro needle can penetrate the skin smoothly by applying force in the direction of rotation rather than applying to the skin, and the pain is less transmitted to the patient, so that the administration of the drug and the sampling of the biological sample such as blood are easy, There is an effect to be shortened.
  • FIG. 1 is a perspective view of a microneedle device according to an embodiment of the present invention
  • FIG. 2 is a front view of a micro needle device according to an embodiment of the present invention
  • FIG 3 is a plan view of a microneedle device according to an embodiment of the present invention.
  • FIG. 1 is a perspective view of a microneedle device according to an embodiment of the present invention
  • FIG. 2 is a front view of a microneedle device according to an embodiment of the present invention
  • FIG. 3 is a cross- And a needle device.
  • the microneedle device 30 is a microneedle device 30 that permeates skin through a patch system to administer a drug or take a biological sample such as blood, 10, and a micro needle 20.
  • the plate 10 is formed in various shapes such as a disk shape and a square plate shape.
  • the micro-needles 20 protrude from one side of the plate 10 and are easy to use
  • a connecting device such as a ring or a projection is further formed.
  • the present invention can be made of a soft material such as a patch, a mask pack, etc. in addition to a hard material such as the plate 10.
  • the micro needle 20 is formed on one side of the patch and the mask pack.
  • the microneedles 20 are formed on one surface of the plate 10 in various shapes such as a quadrangular pyramid, a triangular pyramid, and a cone.
  • the microneedles 20 are formed obliquely The drug is directly inserted into the skin, and the drug is penetrated into the skin.
  • the micro needle 20 is largely transferred in four ways.
  • a solid type microneedle 20 system in which a micro needle 20 is applied to the skin to puncture and a drug is applied to a site where the micro needle 20 is pulled out to spread the drug through the hole.
  • coated drug is applied to the skin by coating the drug to be delivered on the surface of the micro needle 20 and the coated micro needle 20 is melted and delivered in the skin.
  • a soluble micro needle (20) system in which a substance such as a water-soluble or biodegradable polymer capable of dissolving in the skin and a drug to be delivered are made together with the micro needle (20).
  • a hollow micro needle (20) is hollow and the liquid drug is delivered into the skin by the applied pressure.
  • micro-needles with holes or porous micro-needles For sampling of biological samples such as blood, micro-needles with holes or porous micro-needles 4) may be used.
  • the microneedle device 30 of the present invention is rotated in one direction when the microneedle 20 is penetrated through the skin (inserted through the skin), so that the microneedle 20 is rotated by the rotation of the microneedle device 30 Or is driven in the diagonal direction of the microneedles 20 to be transmitted to the skin. That is, the microneedle device 30 is permeated to the skin in various ways, such as being transmitted through the skin while being rotated in the oblique direction of the microneedle 20, or being transmitted in a linear motion in the oblique direction of the microneedle 20.
  • the microneedles 20 are formed on one surface of the plate 10 such that two or more of the microneedles 20 are spaced apart from each other.
  • the microneedles 20 are formed around the rotational axis of the plate 10. That is, two or more of the micro needles 20 are spaced apart from each other, and the micro needles 20 are arranged around the rotation axis.
  • the microneedles 20 are formed of two or more spaced apart micro-needles 20, but they are formed in a spiral shape about the rotational axis toward the center of the plate 10 of the plate 10 .
  • the microneedles 20 are formed in various shapes and are inclined in the direction of rotation of the microneedle device 30.
  • the inclination angle of the microneedles 20 corresponds to 0 ° ⁇ ⁇ ⁇ 90 °.
  • the angle of the microneedles 20 may be varied according to the angle of the microneedles 20.
  • each inclined microneedle is different in length so that it can be manufactured and changed in design so that the degree of insertion of the microneedle is different according to the purpose.
  • a through hole (not shown) is formed on one side of the microneedle 20 so that a medicine can be administered or a biological sample such as blood can be collected.
  • the through hole penetrates to one side of the plate, Or biological samples such as blood can be collected.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif à micro-aiguilles et, plus spécifiquement, un dispositif à micro-aiguilles, dans lequel des micro-aiguilles sont formées de façon à saillir obliquement d'un côté d'une plaque afin d'être inclinées dans la direction de rotation du dispositif à micro-aiguilles. Ainsi, il est facile d'utiliser le dispositif à micro-aiguilles car les micro-aiguilles peuvent pénétrer en douceur la peau par application d'une force dans la direction de rotation plutôt que par un procédé classique qui exerce une force dans la direction verticale pour appliquer les micro-aiguilles sur la peau. De plus, les patients souffrent moins, ce qui facilite l'administration de médicaments et la collecte d'échantillons biologiques tels que le sang, raccourcissant ainsi le temps de travail.
PCT/KR2018/007687 2017-07-07 2018-07-06 Dispositif à micro-aiguilles WO2019009659A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170086195A KR20190005478A (ko) 2017-07-07 2017-07-07 마이크로니들 디바이스
KR10-2017-0086195 2017-07-07

Publications (1)

Publication Number Publication Date
WO2019009659A1 true WO2019009659A1 (fr) 2019-01-10

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Application Number Title Priority Date Filing Date
PCT/KR2018/007687 WO2019009659A1 (fr) 2017-07-07 2018-07-06 Dispositif à micro-aiguilles

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KR (1) KR20190005478A (fr)
WO (1) WO2019009659A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102243443B1 (ko) * 2018-10-31 2021-04-22 서석배 니들 유닛, 니들 팁 및 피부 관리 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090054842A1 (en) * 2003-11-18 2009-02-26 Nanopass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
JP2012090795A (ja) * 2010-10-27 2012-05-17 Asti Corp マイクロニードルアレイ
JP5053645B2 (ja) * 2005-01-14 2012-10-17 久光製薬株式会社 医薬物運搬用器具とその製造方法
US20150374967A1 (en) * 2013-02-13 2015-12-31 Hisamitsu Pharmaceutical Co., Inc. Microneedle Array
KR101624488B1 (ko) * 2016-01-22 2016-05-26 주식회사 퓨처바이오웍스 혈관 문합기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2548608B1 (fr) 2010-03-19 2018-01-31 CosMED Pharmaceutical Co., Ltd. Réseau de micro-aiguilles à teneur en protéoglycane

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090054842A1 (en) * 2003-11-18 2009-02-26 Nanopass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
JP5053645B2 (ja) * 2005-01-14 2012-10-17 久光製薬株式会社 医薬物運搬用器具とその製造方法
JP2012090795A (ja) * 2010-10-27 2012-05-17 Asti Corp マイクロニードルアレイ
US20150374967A1 (en) * 2013-02-13 2015-12-31 Hisamitsu Pharmaceutical Co., Inc. Microneedle Array
KR101624488B1 (ko) * 2016-01-22 2016-05-26 주식회사 퓨처바이오웍스 혈관 문합기

Also Published As

Publication number Publication date
KR20190005478A (ko) 2019-01-16

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