WO2019009412A1 - Nouveau composé ayant une activité inhibitrice de l'enzyme 1 déméthylase spécifique de la lysine, son procédé de production et son utilisation - Google Patents

Nouveau composé ayant une activité inhibitrice de l'enzyme 1 déméthylase spécifique de la lysine, son procédé de production et son utilisation Download PDF

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WO2019009412A1
WO2019009412A1 PCT/JP2018/025702 JP2018025702W WO2019009412A1 WO 2019009412 A1 WO2019009412 A1 WO 2019009412A1 JP 2018025702 W JP2018025702 W JP 2018025702W WO 2019009412 A1 WO2019009412 A1 WO 2019009412A1
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substituted
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alkyl
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梅原　崇史
心 佐藤
小山　裕雄
山本　博文
近藤　豊
啓佑 勝島
雄祐 古川
次郎 菊池
泰子 甲田
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国立研究開発法人理化学研究所
公立大学法人名古屋市立大学
学校法人自治医科大学
国立大学法人名古屋大学
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Publication of WO2019009412A1 publication Critical patent/WO2019009412A1/fr

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Abstract

La présente invention aborde le problème de la fourniture d'un nouveau composé ayant une activité inhibitrice de LSD1 élevée, une sélectivité élevée pour l'inhibition de LSD1, et/ou ayant des effets thérapeutiques utiles pour diverses maladies. Selon un mode de réalisation, la présente invention concerne : un composé représenté par la formule (I) [dans la formule, les significations de L et A sont telles que définies dans la description et les revendications], l'invention concerne également un stéréoisomère dudit composé, un sel de celui-ci ou du stéréoisomère, ou un solvate du composé ou du stéréoisomère. Selon un autre mode de réalisation, la présente invention concerne également : un procédé de production d'un composé représenté par la formule (I), un stéréoisomère de celui-ci ou un sel du composé ou du stéréoisomère, ou un solvate du composé ou du stéréoisomère; et un inhibiteur de LSD1, un médicament et une composition pharmaceutique contenant ledit composé, son stéréoisomère, un sel du composé ou du stéréoisomère, ou un solvate du composé ou du stéréoisomère en tant que composant efficace.
PCT/JP2018/025702 2017-07-07 2018-07-06 Nouveau composé ayant une activité inhibitrice de l'enzyme 1 déméthylase spécifique de la lysine, son procédé de production et son utilisation WO2019009412A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138398A1 (fr) * 2018-12-28 2020-07-02 国立研究開発法人理化学研究所 Nouveau composé inhibiteur de l'enzyme 1 déméthylase spécifique de la lysine, son procédé de production et son utilisation
WO2020188089A1 (fr) 2019-03-20 2020-09-24 Oryzon Genomics, S.A. Procédés de traitement d'un trouble d'hyperactivité avec déficit de l'attention au moyen d'inhibiteurs de kdm1a tels que le composé vafidemstat
WO2020188090A1 (fr) 2019-03-20 2020-09-24 Oryzon Genomics, S.A. Procédés de traitement d'un trouble de la personnalité borderline
US11452711B2 (en) 2020-09-03 2022-09-27 Pfizer Inc. Nitrile-containing antiviral compounds
WO2022214303A1 (fr) 2021-04-08 2022-10-13 Oryzon Genomics, S.A. Combinaisons d'inhibiteurs de lsd1 pour le traitement de cancers myéloïdes
WO2023217758A1 (fr) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Méthodes de traitement d'une tumeur maligne des gaines des nerfs périphériques (tmgnp) à l'aide d'inhibiteurs de lsd1
WO2023217784A1 (fr) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Méthodes de traitement de tumeurs mutantes nf1 à l'aide d'inhibiteurs de lsd1

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138398A1 (fr) * 2018-12-28 2020-07-02 国立研究開発法人理化学研究所 Nouveau composé inhibiteur de l'enzyme 1 déméthylase spécifique de la lysine, son procédé de production et son utilisation
WO2020188089A1 (fr) 2019-03-20 2020-09-24 Oryzon Genomics, S.A. Procédés de traitement d'un trouble d'hyperactivité avec déficit de l'attention au moyen d'inhibiteurs de kdm1a tels que le composé vafidemstat
WO2020188090A1 (fr) 2019-03-20 2020-09-24 Oryzon Genomics, S.A. Procédés de traitement d'un trouble de la personnalité borderline
US11452711B2 (en) 2020-09-03 2022-09-27 Pfizer Inc. Nitrile-containing antiviral compounds
US11541034B2 (en) 2020-09-03 2023-01-03 Pfizer Inc. Nitrile-containing antiviral compounds
WO2022214303A1 (fr) 2021-04-08 2022-10-13 Oryzon Genomics, S.A. Combinaisons d'inhibiteurs de lsd1 pour le traitement de cancers myéloïdes
WO2023217758A1 (fr) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Méthodes de traitement d'une tumeur maligne des gaines des nerfs périphériques (tmgnp) à l'aide d'inhibiteurs de lsd1
WO2023217784A1 (fr) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Méthodes de traitement de tumeurs mutantes nf1 à l'aide d'inhibiteurs de lsd1

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