WO2019004780A3 - 신규한 o-숙시닐 호모세린 트랜스퍼라제 변이체 및 이를 이용한 o-숙시닐 호모세린의 제조방법 - Google Patents
신규한 o-숙시닐 호모세린 트랜스퍼라제 변이체 및 이를 이용한 o-숙시닐 호모세린의 제조방법 Download PDFInfo
- Publication number
- WO2019004780A3 WO2019004780A3 PCT/KR2018/007409 KR2018007409W WO2019004780A3 WO 2019004780 A3 WO2019004780 A3 WO 2019004780A3 KR 2018007409 W KR2018007409 W KR 2018007409W WO 2019004780 A3 WO2019004780 A3 WO 2019004780A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- succinyl homoserine
- producing
- novel
- same
- transferase mutant
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/08—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by replacement of hydroxy groups or etherified or esterified hydroxy groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01031—Homoserine O-acetyltransferase (2.3.1.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02004—Aspartate kinase (2.7.2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/15—Corynebacterium
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18822856.3A EP3647415A4 (en) | 2017-06-30 | 2018-06-29 | NEW O-SUCCINYL HOMOSERIN TRANSFERASE MUTANT, AND PROCESS FOR THE PRODUCTION OF O-SUCCINYL HOMOSERIN USING THEIT MUTANT |
CN201880044236.1A CN111032862B (zh) | 2017-06-30 | 2018-06-29 | 新型o-琥珀酰高丝氨酸转移酶突变体及使用其生产o-琥珀酰高丝氨酸的方法 |
JP2019571997A JP6946479B2 (ja) | 2017-06-30 | 2018-06-29 | 新規なo−スクシニルホモセリントランスフェラーゼ変異体及びこれを用いたo−スクシニルホモセリンの製造方法 |
BR112019028095-2A BR112019028095B1 (pt) | 2017-06-30 | 2018-06-29 | Mutante de o-succinil homosserina transferase inovador e método para produção de o-succinil homosserina com o uso da mesma |
RU2020100480A RU2747494C1 (ru) | 2017-06-30 | 2018-06-29 | Новый мутант О-сукцинилгомосеринтрансферазы и способ получения О-сукцинилгомосерина с использованием этого мутанта |
US16/627,572 US10982245B2 (en) | 2017-06-30 | 2018-06-29 | O-succinyl homoserine transferase mutant and method for producing O-succinyl homoserine using same |
SG11201913899UA SG11201913899UA (en) | 2017-06-30 | 2018-06-29 | Novel o-succinyl homoserine transferase mutant and method for producing o-succinyl homoserine using same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20170083439 | 2017-06-30 | ||
KR10-2017-0083439 | 2017-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2019004780A2 WO2019004780A2 (ko) | 2019-01-03 |
WO2019004780A3 true WO2019004780A3 (ko) | 2019-03-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2018/007409 WO2019004780A2 (ko) | 2017-06-30 | 2018-06-29 | 신규한 o-숙시닐 호모세린 트랜스퍼라제 변이체 및 이를 이용한 o-숙시닐 호모세린의 제조방법 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10982245B2 (ko) |
EP (1) | EP3647415A4 (ko) |
JP (1) | JP6946479B2 (ko) |
KR (1) | KR102112208B1 (ko) |
CN (1) | CN111032862B (ko) |
BR (1) | BR112019028095B1 (ko) |
RU (1) | RU2747494C1 (ko) |
SG (1) | SG11201913899UA (ko) |
WO (1) | WO2019004780A2 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020262686A1 (ja) | 2019-06-28 | 2020-12-30 | 富士フイルム株式会社 | 機上現像型平版印刷版原版、平版印刷版の作製方法、及び、平版印刷方法 |
KR102277404B1 (ko) * | 2021-01-27 | 2021-07-14 | 씨제이제일제당 주식회사 | 신규한 갈락토사이드 o-아세틸트랜스퍼라제 변이체 및 이를 이용한 l-글루탐산 생산 방법 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015060649A1 (ko) * | 2013-10-23 | 2015-04-30 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
US20150211034A1 (en) * | 2006-07-28 | 2015-07-30 | Cj Cheiljedang Corporation | Microorganism Producing L-Methionine Precursor and Method of Producing L-Methionine and Organic Acid from the L-Methionine Precursor |
WO2016179545A1 (en) * | 2015-05-06 | 2016-11-10 | Trelys, Inc. | Compositions and methods for biological production of methionine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
KR100620092B1 (ko) | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
US20090298136A1 (en) * | 2005-07-18 | 2009-12-03 | Basf Ag | Methionine producing recombinant microorganisms |
JP5756259B2 (ja) | 2006-09-15 | 2015-07-29 | シージェイ チェイルジェダン コーポレイション | L−リジン生産能の向上したコリネバクテリウム属およびそれを用いたl−リジン生産方法 |
KR100930203B1 (ko) | 2008-01-28 | 2009-12-07 | 씨제이제일제당 (주) | 개량된 프로모터 및 이를 이용한 l-라이신의 생산 방법 |
KR101048593B1 (ko) | 2009-02-27 | 2011-07-12 | 씨제이제일제당 (주) | 메칠머캅탄과 디메칠설파이드의 혼합물을 사용하여 메치오닌 생산능을 증가시키는 방법 |
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2018
- 2018-06-29 US US16/627,572 patent/US10982245B2/en active Active
- 2018-06-29 SG SG11201913899UA patent/SG11201913899UA/en unknown
- 2018-06-29 BR BR112019028095-2A patent/BR112019028095B1/pt active IP Right Grant
- 2018-06-29 EP EP18822856.3A patent/EP3647415A4/en active Pending
- 2018-06-29 RU RU2020100480A patent/RU2747494C1/ru active
- 2018-06-29 KR KR1020180075570A patent/KR102112208B1/ko active IP Right Grant
- 2018-06-29 WO PCT/KR2018/007409 patent/WO2019004780A2/ko active Application Filing
- 2018-06-29 JP JP2019571997A patent/JP6946479B2/ja active Active
- 2018-06-29 CN CN201880044236.1A patent/CN111032862B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150211034A1 (en) * | 2006-07-28 | 2015-07-30 | Cj Cheiljedang Corporation | Microorganism Producing L-Methionine Precursor and Method of Producing L-Methionine and Organic Acid from the L-Methionine Precursor |
WO2015060649A1 (ko) * | 2013-10-23 | 2015-04-30 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
WO2016179545A1 (en) * | 2015-05-06 | 2016-11-10 | Trelys, Inc. | Compositions and methods for biological production of methionine |
Non-Patent Citations (2)
Title |
---|
DATABASE Protein 4 March 2015 (2015-03-04), ANONYMOUS: "homoserine O-acetyltransferase [Corynebacterium glutamicum]", XP055584458, retrieved from NCBI Database accession no. WP_011013793.1 * |
MORDUKHOVA, ELENA A.: "Stabilized homoserine o-succinyltransferases (MetA) or L-methionine partially recovers the growth defect in Escherichia coli lacking ATP-dependent proteases or the DnaK chaperone", BMC MICROBIOLOGY, vol. 13, no. 179, 30 July 2013 (2013-07-30), pages 1 - 13, XP021157782 * |
Also Published As
Publication number | Publication date |
---|---|
KR20190003402A (ko) | 2019-01-09 |
CN111032862A (zh) | 2020-04-17 |
KR102112208B1 (ko) | 2020-05-19 |
CN111032862B (zh) | 2023-09-19 |
EP3647415A4 (en) | 2021-02-24 |
BR112019028095A2 (pt) | 2020-07-14 |
US20200224228A1 (en) | 2020-07-16 |
JP6946479B2 (ja) | 2021-10-06 |
BR112019028095B1 (pt) | 2023-03-21 |
SG11201913899UA (en) | 2020-01-30 |
EP3647415A2 (en) | 2020-05-06 |
WO2019004780A2 (ko) | 2019-01-03 |
RU2747494C1 (ru) | 2021-05-05 |
JP2020525018A (ja) | 2020-08-27 |
US10982245B2 (en) | 2021-04-20 |
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