WO2018234479A3 - Verfahren zur vereinheitlichung von gallensäurederivaten - Google Patents

Verfahren zur vereinheitlichung von gallensäurederivaten Download PDF

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Publication number
WO2018234479A3
WO2018234479A3 PCT/EP2018/066625 EP2018066625W WO2018234479A3 WO 2018234479 A3 WO2018234479 A3 WO 2018234479A3 EP 2018066625 W EP2018066625 W EP 2018066625W WO 2018234479 A3 WO2018234479 A3 WO 2018234479A3
Authority
WO
WIPO (PCT)
Prior art keywords
bile acid
preparing
acid
acid derivatives
homogenizing
Prior art date
Application number
PCT/EP2018/066625
Other languages
English (en)
French (fr)
Other versions
WO2018234479A2 (de
Inventor
Ulf Menyes
Philipp Süß
Henrike BRUNDIEK
Melinda FEKETE
Original Assignee
Enzymicals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzymicals Ag filed Critical Enzymicals Ag
Priority to EP18733847.0A priority Critical patent/EP3642216A2/de
Priority to US16/625,967 priority patent/US20210155653A1/en
Publication of WO2018234479A2 publication Critical patent/WO2018234479A2/de
Publication of WO2018234479A3 publication Critical patent/WO2018234479A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Gallensäurederivaten mit geschützter Hydroxylgruppe in 3-Position umfassend das Kontaktieren eines Gallensäurederivats mit ungeschützter 3-alpha-Hydroxylgruppe mit einer spezifischen Lipase. Weiterhin betrifft die Erfindung ein Gallensäurederivat, erhalten oder erhältlich gemäß den Verfahren, die Verwendung des Gallensäurederivats erhalten oder erhältlich nach dem Verfahren zur Herstellung von Lithocholsäure, sowie ein Verfahren zur Herstellung von Lithocholsäure und nach dem Verfahren erhaltene Lithocholsäure. Weiterhin betrifft die Erfindung die Verwendung von Lithocholsäure erhalten oder erhältlich nach dem Verfahren zur Herstellung von Ursodesoxycholsäure oder Ursodesoxycholsäurederivaten.
PCT/EP2018/066625 2017-06-22 2018-06-21 Verfahren zur vereinheitlichung von gallensäurederivaten WO2018234479A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP18733847.0A EP3642216A2 (de) 2017-06-22 2018-06-21 Verfahren zur vereinheitlichung von gallensäurederivaten
US16/625,967 US20210155653A1 (en) 2017-06-22 2018-06-21 Method for homogenizing bile acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017210542.9 2017-06-22
DE102017210542 2017-06-22

Publications (2)

Publication Number Publication Date
WO2018234479A2 WO2018234479A2 (de) 2018-12-27
WO2018234479A3 true WO2018234479A3 (de) 2019-03-21

Family

ID=62716069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/066625 WO2018234479A2 (de) 2017-06-22 2018-06-21 Verfahren zur vereinheitlichung von gallensäurederivaten

Country Status (3)

Country Link
US (1) US20210155653A1 (de)
EP (1) EP3642216A2 (de)
WO (1) WO2018234479A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113999886B (zh) * 2021-12-06 2023-07-04 江苏省农业科学院 一种一锅法酶解提取鸡胆汁酸的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017035501A1 (en) * 2015-08-27 2017-03-02 Academia Sinica Sialyltransferase inhibitors and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS236228B1 (cs) * 1983-10-07 1985-05-15 Vladimir Schwarz Způsob výroby 3<x-acetoxyderivátů žlučových kyselin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017035501A1 (en) * 2015-08-27 2017-03-02 Academia Sinica Sialyltransferase inhibitors and uses thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FRANCESCO SECUNDO ET AL: "A combinatorial biocatalysis approach to an array of cholic acid derivatives", BIOTECHNOLOGY AND BIOENGINEERING, vol. 81, no. 4, 20 February 2003 (2003-02-20), US, pages 391 - 396, XP055503546, ISSN: 0006-3592, DOI: 10.1002/bit.10486 *
GUADALUPE GARCÍA LIÑARES ET AL: "Enzymatic synthesis of bile acid derivatives and biological evaluation against Trypanosoma cruzi", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 15, 1 August 2015 (2015-08-01), GB, pages 4804 - 4814, XP055503270, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2015.05.035 *
HASLEWOOD G A: "Comparative studies of bile salts. 9. The isolation and chemistry of hyocholic acid.", THE BIOCHEMICAL JOURNAL APR 1956, vol. 62, no. 4, April 1956 (1956-04-01), pages 637 - 645, XP002786435, ISSN: 0264-6021 *
KAGAN H B ET AL: "[3 alpha-Hydroxy-delta 6-cholenic acid & 3 alpha, 6 beta, 7 beta-trihydroxycholanic acid].", COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L'ACADEMIE DES SCIENCES 16 DEC 1957, vol. 245, no. 25, 16 December 1957 (1957-12-16), pages 2417 - 2420, XP002786434, ISSN: 0001-4036 *
MATKOVICS B ET AL: "Hydroboration of B-ring unsaturated bile acids", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 5, no. 1, 1 January 1965 (1965-01-01), pages 117 - 121, XP023431562, ISSN: 0039-128X, [retrieved on 19650101], DOI: 10.1016/0039-128X(65)90137-6 *
SATU STRANDMAN ET AL: "Ring-opening polymerization of bile acid macrocycles by Candida antarctica lipase B", POLYMER CHEMISTRY, vol. 4, no. 16, 1 January 2013 (2013-01-01), GB, pages 4312, XP055503253, ISSN: 1759-9954, DOI: 10.1039/c3py00651d *
SERGIO RIVA ET AL: "Regioselective acylation of bile acid derivatives with Candida cylindracea lipase in anhydrous benzene", JOURNAL OF ORGANIC CHEMISTRY, vol. 54, no. 13, 1 June 1989 (1989-06-01), US, pages 3161 - 3164, XP055503236, ISSN: 0022-3263, DOI: 10.1021/jo00274a036 *
SUGAI T ET AL: "EFFICIENT LIPASE-CATALYZED PREPARATION OF LONG-CHAIN FATTY ACID ESTERS OF BILE ACIDS: BIOLOGICAL ACTIVITY AND SYNTHETIC APPLICATIONOF THE PRODUCTS", BIOSCI. BIOTECH. BIOCHEM,, vol. 60, no. 12, 1 January 1996 (1996-01-01), pages 2059 - 2063, XP002922819, ISSN: 0916-8451 *

Also Published As

Publication number Publication date
WO2018234479A2 (de) 2018-12-27
US20210155653A1 (en) 2021-05-27
EP3642216A2 (de) 2020-04-29

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