WO2018232741A1 - 一种防治瘟疫的药丸及其制备方法 - Google Patents

一种防治瘟疫的药丸及其制备方法 Download PDF

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WO2018232741A1
WO2018232741A1 PCT/CN2017/089784 CN2017089784W WO2018232741A1 WO 2018232741 A1 WO2018232741 A1 WO 2018232741A1 CN 2017089784 W CN2017089784 W CN 2017089784W WO 2018232741 A1 WO2018232741 A1 WO 2018232741A1
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parts
pellet
radix
pill
plague
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PCT/CN2017/089784
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French (fr)
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郭建钊
江红格
申涛
郭宇鹏
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禹州市天源生物科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to a medicine used in the field of disease treatment, in particular to a medicine for preventing and treating plague and a preparation method thereof.
  • Blight disease is a general term for epidemic infectious diseases in Chinese history, including various diseases caused by viruses, bacteria, parasites and other microorganisms.
  • the epidemic with fever as the main symptom is called plague.
  • SARS is a modern plague. SARS has been recognized as the first worldwide catastrophic infectious disease of the century, and the social and economic losses have been difficult to estimate.
  • the plague is caused by some highly pathogenic microorganisms, such as bacteria and viruses. It is generally caused by poor sanitation after a natural disaster.
  • the plague has long been recorded in Chinese historical materials. For example, “Zhou Li Tianguan ⁇ Zai Zai” records: “Diseases raise the disease of the people, and there are dysentery at four o'clock.” “Lv's Spring and Autumn ⁇ Ji Chun Ji” records: “The season is the summer season, the people are sick.” "The understanding of the plague at that time has reached a certain level, and it is believed that the plague can occur all year round.
  • Wind the disease is painful, the head is painful, the heat is annoying, the throat is dry Drink.” Point out that the plague is characterized by contagiousness, epidemics, similar clinical manifestations, and morbidity and climate. It is believed that as long as “positive gas is stored in the air”, it can “avoid its poison gas”.
  • the object of the present invention is to provide a pill for preventing and treating plague, so as to solve the above problems existing in the prior art, and the pill for preventing and treating plague according to the present invention can be quickly and effectively relieved of symptoms, cured, and prevented by taking the medicine according to the course of treatment. The effect of the infection with the plague.
  • a pill for controlling plague which is prepared by mixing a main medicament and a secondary medicament, wherein the main medicament is made by the following components by weight: 4-6 parts of Chuanhuanghuang, Yuan 2-4 parts, 2-4 parts of perilla, 2-4 parts of pueraria, 2-4 parts of Bupleurum, 2-4 parts of citron, 1-3 parts of musk, 1-3 parts of oyster shell, 1-3 of geranium powder 1-2 parts of red peony, 2-3 parts of forsythia, 1-3 parts of scorpion, 2-3 parts of white peony, 1-3 parts of windproof, 1-3 parts of schizonepeta, 1-3 parts of scutellaria, sage 0.5-1.5 parts, 0.5-1 parts of asarum; the auxiliary agent is made up of the following components by weight: 3-5 parts of Artemisia argyi and 3-5 parts of Chencang rice.
  • the preparation method of the above-mentioned pill for controlling plague includes the following steps:
  • the pellets are cut into strips by hand or pelletized for further cutting into pellets.
  • the thickness of the pellets depends on the size of the pellets, and is rubbed on the hands or tools during the purlins. Apply lubricant to avoid sticking the pellet to the hand or tool;
  • the pellet prepared in the step (5) is dried at 45-55 ° C to prevent the surface of the pellet from cracking, and when it is nearly dry, the temperature is raised to 60-70 ° C until the pellet is sufficiently dried to obtain a pill;
  • the lubricant is made by masing yellow oil and yellow wax by heat fusion at 3:1.
  • Yuanshen sexual taste bitter, salty, slightly cold, return to the lungs, kidney, with nourishing yin and reducing fire, moistening dryness and fluid, reducing swelling and detoxification effect, attending fever, yin, thirst, constipation, hair spot, sore throat ⁇ ⁇ swollen embolism.
  • Perilla Sexual taste, warm, into the lungs, spleen, with a wide range of qi and qi, Jieyu and fetus, the main treatment is mainly used to treat exogenous cold and chest tightness, nausea, vomiting.
  • the effect of sweating of sage leaves is much weaker than that of ephedra and cassia twigs. It is not effective in single use. It should be used in combination with schizonepeta, windproof or ginger to help sweat. However, its specialty is to be able to regulate qi and vomit.
  • Pueraria Sexual sweetness, Xin, Ping, into the spleen, stomach, with the expression of fever, Shengjinzhike effect, attending symptoms, fever, no sweat, head pain, fever, thirst, thirst, plaque is not transparent , spleen deficiency diarrhea and other symptoms.
  • Bupleurum Sexual taste bitter, flat, into the liver, gallbladder, with fever and fever, liver dispelling depression, Shengyang effect, attending cold and fever, cold and heat, malaria, chest pain and pain, irregular menstruation.
  • Toon Sexually sweet, slightly warm, into the lungs, spleen, stomach. Has a sweating heat, and the effect of the Chinese and dampness, attending the heat, cold and sweatless, abdominal pain, vomiting, edema, athlete's foot embolism.
  • Clam shell Sexual taste bitter, cold, sour, into the spleen, stomach two classics, with broken gas and eliminate the product, phlegm and phlegm removal effect, attending food stagnation, chest and abdomen full of pain, liver qi stagnation, hypochondriac pain And sputum embolism.
  • Trichosanthin Sexually bitter, cold, into the lungs, stomach, with Shengjin, thirst, reduce fire, run dry, discharge pus, swelling effect. Indications for fever, thirst, diabetes, jaundice, lung dry hemoptysis, carbuncles, sputum embolism.
  • Red peony sexual acidity, bitterness, slightly cold, into the liver, with clear diarrhea and liver fire, dilated phlegm and blood circulation, analgesic effect, attending irregular menstruation, stagnation of abdominal pain, closed sputum, swollen sore, joint swelling Pain, chest pain and other symptoms.
  • Forsythia sexual taste bitterness, cold, heart, small intestine, with clear heart and heat, swelling and dispersing, diuretic effect, attending external wind and heat, acute fever, initial fever, dizziness, sputum, swollen sore, sputum ⁇ Equivalent.
  • ⁇ Sexual taste, bitterness, warmth, into the bladder, liver, kidney, with scattered wind and cold, pain, efficacy, cold, cold, headache, body pain, rheumatism and other symptoms.
  • White peony Sexual taste, warm, into the lungs, stomach, with the release of scattered wind, swelling and pain relief, attending cold headache, nasal congestion, nose pain, eyebrows, bone pain, swelling and sore.
  • Windproof Sexual taste, sweetness, warmness, into the bladder, lung, liver, spleen, with the effect of releasing scattered wind, Shengshijiejie, attending headaches caused by cold or rheumatism, dizziness, pain, tetanus and other symptoms.
  • Nepeta Sexual taste, warm, into the lungs, liver, have a sweating solution, dilated and stopped bleeding, attending the exogenous cold, measles early in the poor hair, charcoal can stop bleeding, uterine bleeding, blood in the stool.
  • Astragalus sexual taste bitter, cold, into the lungs, spleen, gallbladder, large and small intestines, with heat and dampness, hemostasis and hepatoprotective effects, attending lung heat cough, blood heat claudication, damp heat, sputum, fetal restlessness and other symptoms.
  • Clematis Spicy, salty, warm, into the twelve classics, with scattered wind and dampness, qi and collateral effect, attending rheumatism, phlegm, numbness and other symptoms.
  • Chen Cangmi Sexually sweet, light, spleen, stomach, heart, large intestine, with stomach, oozing, detoxification effect.
  • the spleen and stomach are weak, polydipsia, diarrhea, nausea, and sputum.
  • Artemisia annua Sexual taste bitter, cold, into the liver, gallbladder, with heat and cool blood, heat and steam removal effect, attending heat and evil, yin deficiency fever, malaria, bone steaming heat syndrome.
  • the invention selects a plurality of traditional Chinese medicinal materials which are effective for plague, and adjusts and enhances the efficacy by selecting appropriate auxiliary drugs, and the compatibility is scientific, and the key of the prescription is the dosage and the collocation, if the collocation is improper, the dosage is insufficient, Insufficient strength, uneven force, unable to clean the virus directly and uprooted, and taking the drug according to the course of treatment can quickly restore health, because the drugs have the effect of clearing away heat and detoxification, cooling blood and pharynx, and each Chinese medicine has synergy or The constrained relationship can enhance human immunity, stimulate human potential, promote human metabolism, and treat plague in multiple ways, thereby greatly improving the therapeutic effect of the drug.
  • the pill is simple to take and is generally applicable to various people. Good therapeutic effect, while at the same time effectively preventing the infection of the plague.
  • a pill for controlling plague is prepared by mixing a main medicament and a secondary medicament, wherein the main medicament is made up of the following components by weight: 4 parts of Rhubarb, 2 parts of Yuanshen, 2 parts of Perilla, 2 parts of Pueraria, 2 parts of firewood 2 parts of Hu, 2 parts of citron, 1 part of musk, 1 part of oyster shell, 1 part of scorpion powder, 1 part of sassafras, 2 parts of forsythia, 1 part of scorpion, 2 parts of white peony, 1 part of windproof, 1 part of schizonepeta, jaundice 1 part, 0.5 parts of Clematis, 0.5 parts of Asarum; the auxiliary agent is made up of the following components by weight: 3 parts of Artemisia argyi and 3 parts of Chen Cangmi.
  • the above method for preparing a pill for preventing and treating plague comprises the following steps:
  • the medicinal material is ground, according to the above requirements, the medicinal material of the main medicament is selected and weighed, and then ground into a fine powder with a fineness of 80 mesh, mixed into a sterilized pot and mixed for use, and the granule is ground into a fine powder of 80 mesh. ,spare;
  • the pellets are cut into strips by hand or pelletized for further cutting into pellets.
  • the thickness of the pellets depends on the size of the pellets, and is rubbed on the hands or tools during the purlins. Wiping the lubricant to prevent the pellet from sticking to the hand or the tool.
  • the lubricant is made by stimulating the sesame oil with the yellow wax by heating at 3:1;
  • the pellet prepared in the step (5) is dried at 45 ° C to prevent the surface of the pellet from cracking, and when it is nearly dry, the temperature is raised to 60 ° C until the pellet is sufficiently dried to obtain a pill;
  • a pill for controlling plague is prepared by mixing a main medicament and a secondary medicament, wherein the main medicament is made up of the following components by weight: 6 parts of Rhubarb, 4 parts of Yuanshen, 4 parts of Perilla, 4 parts of Pueraria, 4 parts of firewood 4 parts of fragrant, 4 parts of citron, 3 parts of musk, 3 parts of oyster shell, 3 parts of geranium powder, 2 parts of erythraea, 3 parts of forsythia, 3 parts of scorpion, 3 parts of white peony, 3 parts of windproof, 3 parts of schizonepeta, jaundice 3 parts, 1.5 parts of Clematis, 1 part of Asarum; the auxiliary agent is made up of the following components by weight: 5 parts of Artemisia argyi and 5 parts of Chen Cangmi.
  • the above method for preparing a pill for preventing and treating plague comprises the following steps:
  • the pellets are cut into strips by hand or pelletized for further cutting into pellets.
  • the thickness of the pellets depends on the size of the pellets, and is rubbed on the hands or tools during the purlins. Wiping the lubricant to prevent the pellet from sticking to the hand or the tool.
  • the lubricant is made by stimulating the sesame oil with the yellow wax by heating at 3:1;
  • the pellet prepared in the step (5) is dried at 55 ° C to prevent the surface of the pellet from cracking, and when it is nearly dry, the temperature is raised to 70 ° C until the pellet is sufficiently dried to obtain a pill;
  • a pill for controlling plague is prepared by mixing a main medicament and a secondary medicament, wherein the main medicament is made up of the following components by weight: 5 parts of Rhubarb, 3 parts of Yuanshen, 3 parts of Perilla, 3 parts of Pueraria, and 3 3 parts of fragrant, 3 parts of citron, 2 parts of musk, 2 parts of oyster shell, 2 parts of geranium powder, 1.5 parts of red peony, 2.5 parts of forsythia, 2 parts of scorpion, 2.5 parts of white peony, 2 parts of windproof, 2 parts of schizonepeta, jaundice 2 parts, 1 part of Clematis, 0.8 parts of Asarum; the auxiliary agent was made by weight of the following components: 4 parts of Artemisia argyi and 4 parts of Chen Cangmi.
  • the above-mentioned pill for preventing and treating plague and the preparation method thereof include the following steps:
  • the pellets are cut into strips by hand or pelletized for further cutting into pellets.
  • the thickness of the pellets depends on the size of the pellets, and is rubbed on the hands or tools during the purlins. Wiping the lubricant to prevent the pellet from sticking to the hand or the tool.
  • the lubricant is made by stimulating the sesame oil with the yellow wax by heating at 3:1;
  • the pellet prepared in the step (5) is dried at 50 ° C to prevent the surface of the pellet from cracking, and when it is nearly dry, the temperature is raised to 65 ° C until the pellet is sufficiently dried to obtain a pill;

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Abstract

一种防治瘟疫的药丸及其制备方法，由主药和副药剂混合制成，其中主药剂由以下组分制成：川大黄、玄参、紫苏、葛根、柴胡、香薷、藿香、枳壳、天花粉、赤芍、连翘、羌活、白芷、防风、荆芥、黄芩、威灵仙、细辛；副药剂由以下组分制成：青蒿汁、陈仓米。

Description

一种防治瘟疫的药丸及其制备方法 技术领域
本发明涉及疾病治疗领域用到的药物，具体涉及一种防治瘟疫的药丸及其制备方法。
背景技术
“疫病”，是中国历史上对流行性传染病的统称，包括因病毒、细菌、寄生虫和其它微生物引起的多种疾病。而以发热为主要症状的疫病则称为瘟疫。照此标准，SARS算是一次现代瘟疫了。SARS已经被公认为是本世纪第一次世界性灾难性传染病，带来的社会和经济了损失尚难以估计。
瘟疫是由于一些强烈致病性微生物，如细菌、病毒引起的传染病。一般是自然灾害后，环境卫生不好引起的。瘟疫在中国史料中早有记载。如《周礼·天官·冢宰》记载：“疾医掌养万民之疾病，四时皆有疠疾。”《吕氏春秋·季春纪》记载：“季春行夏令，则民多疾疫。”说明当时对瘟疫的认识已经达到了一定水平，认为瘟疫一年四季皆可发生，原因之一是由于时令之气的不正常，是由“非时之气”造成的。现存最早的中医古籍《黄帝内经》也有记载。如《素问·刺法论》指出：“五疫之至，皆向染易，无问大小，病状相似，正气存内，邪不可干，避其毒气。”《素问·本能病》篇：“厥阴不退位，即大风早举，时雨不降，湿令不化，民病瘟疫，疵废。风生，民病皆肢节痛、头目痛，伏热内烦，咽喉干引饮。”指出瘟疫具有传染性、流行性、临床表现相似、发病与气候有关等特点，并认为只要“正气存内”，就能“避其毒气”。
发明内容
本发明的目的是提供一种防治瘟疫的药丸，以解决现有技术中存在的上述问题，用本发明的防治瘟疫的药丸，按照疗程服用，可以快速有效地缓解症状，治愈患者，而且具有预防感染瘟疫的效果。
为实现上述目的，本发明采用如下技术方案：一种防治瘟疫的药丸，由主药剂和副药剂混合制成，其中主药剂按重量百分比由以下组分制成：川大黄4-6份，元参2-4份，紫苏2-4份，葛根2-4份，柴胡2-4份，香薷2-4份，藿香1-3份，枳壳1-3份，天花粉1-3份，赤芍1-2份，连翘2-3份，羌活1-3份，白芷2-3份，防风1-3份，荆芥1-3份，黄芩1-3份，威灵仙0.5-1.5份，细辛0.5-1份；副药剂按重量百分比由以下组分制成：青蒿汁3-5份，陈仓米3-5份。
上述用于防治瘟疫的药丸的制备方法，包括如下步骤：
(1)药材磨粉，按照上述要求选用并称量制取主药剂的药材，然后磨成细度为80-120目的细粉，装入消毒盆中混匀备用，将陈仓米磨成80-120目的细粉，备用；
(2)制糊，称取纯水40-45份，按上述要求称量陈仓米粉，在纯水中加入称量好的陈仓米粉，搅拌混匀，并进行加热，在加热过程中进行搅拌，以避免糊底，煮沸后静置直到形成糨糊；
(3)捏合，将上述糨糊倒入步骤(1)所得的药粉中搅匀，并在搅拌的过程中，按照上述所述的比例加入青蒿汁，在加入青蒿汁的同时用搅拌工具在药粉内朝同一方向圆周搅动，然后用手趁热用力搅拌捏合，制成丸块备用；
(4)搓条，将丸块用手或制丸板搓成长条状的丸条，以便进一步切割为丸剂，丸条的粗细按丸剂的大小而定，在搓条时在手或工具上擦抹润滑剂，以避免丸块粘在手上或工具上；
(5)成型，将丸条分割成等量的小粒，再用手或制丸板搓成圆形的丸剂；
(6)干燥，将步骤(5)制成的丸剂在45-55℃进行干燥，以免丸剂的表面发裂，至接近干燥时，温度升高至60-70℃，至丸剂充分干燥得到药丸；
(7)包装，备好无毒的塑料薄膜或皮纸，将制备好的药丸进行包裹。
作为本发明防治瘟疫的药丸的制备方法的进一步改进，所述润滑剂系麻油与黄蜡按3:1加热融合制成。
本发明中，各药材的药理药效如下：
川大黄：性味苦、甘、大寒，归胃、大肠、肝经，主治泻热毒，破积滞，行瘀血。治实热便秘，谵语发托，食积痞满，痢疾初起，里急后重，瘀停经闭，百瘕积聚，时行热疫，暴眼赤痛，吐血，衄血，阳黄，水肿，淋浊，溲亦，痈疡肿毒，疔疮，汤火伤。
元参：性味苦、咸、微寒，归肺、肾经，具有滋阴降火，润燥生津、消肿解毒功效，主治热病伤阴，口渴，便秘，发斑，咽喉肿痛，痈肿瘰疠等症。
紫苏：性味辛、温，入肺、脾经，具有理气宽胸，解郁安胎功效，主治主要用于治疗外感风寒而兼有胸闷、恶心、呕吐者。苏叶发汗的作用比麻黄、桂枝弱得多，单用效力不大，要与荆芥、防风或生姜等同用以助发汗。但它的特长是兼能理气宽中，止呕。
葛根：性味甘、辛、平，入脾、胃经，具有发表退热，生津止渴功效，主治表症发热无汗，头项强痛，热病口渴，消渴，斑疹不透，脾虚泄泻等症。
柴胡：性味苦、平，入肝、胆经，具有发热退热、疏肝解郁、升阳功效，主治感冒发烧，寒热往来，疟疾，胸胁胀痛，月经不调等症。
香薷：性味辛、微温，入肺、脾、胃经。具有发汗解暑，和中利湿功效，主治伤暑，形寒无汗，腹痛吐泻，水肿，脚气等症。
藿香：性味辛、微温，入肺、脾、胃经，主治快气，和中，辟秽，祛湿。 主治感冒暑湿，寒热，头痛，胸脘痞闷，呕吐泄泻，疟疾，痢疾，口臭等症。
枳壳：性味苦、寒、酸，入脾、胃二经，具有破气消积，化痰除痞功效，主治食积痰滞不消，胸腹痞满胀痛，肝郁气滞，胁痛及下痢等症。
天花粉：性味苦、寒，入肺、胃经，具有生津，止渴，降火，润燥，排脓，消肿功效。主治热病口渴，消渴，黄疸，肺燥咳血，痈肿，痔瘘等症。
赤芍：性味酸、苦、微寒，入肝经，具有清泄肝火，散瘀活血，止痛功效功效，主治月经不调，瘀滞腹痛，经闭徵瘕，痈肿疮毒，关节肿痛，胸胁疼痛等症。
连翘：性味苦、寒，入心、小肠经，具有清心解热，消肿散结，利尿功效，主治外感风热，急性热病初起，烦热神昏，痈肿疮毒，瘰疠等症。
羌活：性味辛、苦、温，入膀胱、肝、肾经，具有散风寒湿，止痛功效，主治感冒风寒，头痛，身痛，风湿痹痛等症。
白芷：性味辛、温，入肺、胃经，具有发表散风，消肿止痛功效，主治感冒头痛、鼻塞，鼻渊疼痛，眉棱骨疼，痈肿疮疡等症。
防风：性味辛、甘、温，入膀胱、肺、肝、脾经，具有发表散风，胜湿解痉功效，主治外感风寒或风湿所致的头痛、目眩骨节疼痛、破伤风等症。
荆芥：性味辛、温，入肺、肝经，具有发汗解表，散瘀止血功效，主治外感风寒，麻疹初期透发不畅，炒炭可止衄血、崩漏、便血。
黄芩：性味苦、寒，入肺、脾、胆、大小肠经，具有清热燥湿，止血安胎功效，主治肺热咳嗽，血热妄行，湿热下痢，胎动不安等症。
威灵仙：性味辛、咸、温，入十二经，具有散风祛湿，行气通络功效，主治风湿痹痛，瘫痪，麻木等症。
细辛：性味辛、温，入肺、肾经，主治祛风，散寒，行水，开窍。治风冷 头痛，鼻渊，齿痛，痰饮咳逆，风湿痹痛等症。
陈仓米：性味甘、淡，归脾、胃、心、大肠经，具有养胃，渗湿，除烦功效。用于病后脾胃虚弱，烦渴，泄泻，反胃，噤口痢。
青蒿：性味苦、寒，入肝、胆经，具有清热凉血，解暑除蒸功效，主治暑邪发热，阴虚发热，疟疾，骨蒸劳热等症。
有益效果
本发明选用对瘟疫有疗效的多种中药材，并通过选用恰当的副药物对药效进行调理增效，配伍科学，药方的关键就是药量和搭配，如果搭配不当，药量不足，就会造成力量不够，发力不均，不能够将病毒直接清理连根拔掉，而按照疗程服用本药品可以快速恢复健康，因诸药具有清热解毒，凉血利咽功效，且各个中药又具有相互协同或制约的关系，因此能够增强人体免疫力，激发人体潜能，促进人体新陈代谢，多途径地治疗瘟疫，从而大大提高了药物发挥的治疗效果，本药丸服用方法简单，普遍适用于各种人群，具有较好的治疗效果，同时能够有效地预防感染瘟疫。
具体实施方式
为了使本发明的技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。
实施例1
一种防治瘟疫的药丸，由主药剂和副药剂混合制成，其中主药剂按重量百分比由以下组分制成：川大黄4份，元参2份，紫苏2份，葛根2份，柴胡2份，香薷2份，藿香1份，枳壳1份，天花粉1份，赤芍1份，连翘2份，羌活1份，白芷2份，防风1份，荆芥1份，黄芩1份，威灵仙0.5份，细辛0.5份；副药剂按重量百分比由以下组分制成：青蒿汁3份，陈仓米3份。
上述防治瘟疫的药丸制备方法，包括如下步骤：
(1)药材磨粉，按照上述要求选用并称量制取主药剂的药材，然后磨成细度为80目的细粉，装入消毒盆中混匀备用，将陈仓米磨成80目的细粉，备用；
(2)制糊，称取纯水40份，按上述要求称量陈仓米粉，在纯水中加入称量好的陈仓米粉，搅拌混匀，并进行加热，在加热过程中进行搅拌，以避免糊底，煮沸后静置直到形成糨糊；
(3)捏合，将上述糨糊倒入步骤(1)所得的药粉中搅匀，并在搅拌的过程中，按照上述比例加入青蒿汁，在加入青蒿汁的同时用搅拌工具在药粉内朝同一方向圆周搅动，然后用手趁热用力搅拌捏合，制成丸块备用；
(4)搓条，将丸块用手或制丸板搓成长条状的丸条，以便进一步切割为丸剂，丸条的粗细按丸剂的大小而定，在搓条时在手或工具上擦抹润滑剂，以避免丸块粘在手上或工具上，所述润滑剂系麻油与黄蜡按3:1加热融合制成；
(5)成型，将丸条分割成等量的小粒，再用手或制丸板搓成圆形的丸剂；
(6)干燥，将步骤(5)制成的丸剂在45℃进行干燥，以免丸剂的表面发裂，至接近干燥时，温度升高至60℃，至丸剂充分干燥得到药丸；
(7)包装，备好无毒的塑料薄膜或皮纸，将制备好的药丸进行包裹。
实施例2
一种防治瘟疫的药丸，由主药剂和副药剂混合制成，其中主药剂按重量百分比由以下组分制成：川大黄6份，元参4份，紫苏4份，葛根4份，柴胡4份，香薷4份，藿香3份，枳壳3份，天花粉3份，赤芍2份，连翘3份，羌活3份，白芷3份，防风3份，荆芥3份，黄芩3份，威灵仙1.5份，细辛1份；副药剂按重量百分比由以下组分制成：青蒿汁5份，陈仓米5份。
上述防治瘟疫的药丸制备方法，包括如下步骤：
(1)药材磨粉，按照上述要求选用并称量制取主药剂的药材，然后磨成细度为120目的细粉，装入消毒盆中混匀备用，将陈仓米磨成120目的细粉，备用；
(2)制糊，称取纯水45份，按上述要求称量陈仓米粉，在纯水中加入称量好的陈仓米粉，搅拌混匀，并进行加热，在加热过程中进行搅拌，以避免糊底，煮沸后静置直到形成糨糊；
(3)捏合，将上述糨糊倒入步骤(1)所得的药粉中搅匀，并在搅拌的过程中，按照上述比例加入青蒿汁，在加入青蒿汁的同时用搅拌工具在药粉内朝同一方向圆周搅动，然后用手趁热用力搅拌捏合，制成丸块备用；
(4)搓条，将丸块用手或制丸板搓成长条状的丸条，以便进一步切割为丸剂，丸条的粗细按丸剂的大小而定，在搓条时在手或工具上擦抹润滑剂，以避免丸块粘在手上或工具上，所述润滑剂系麻油与黄蜡按3:1加热融合制成；
(5)成型，将丸条分割成等量的小粒，再用手或制丸板搓成圆形的丸剂；
(6)干燥，将步骤(5)制成的丸剂在55℃进行干燥，以免丸剂的表面发裂，至接近干燥时，温度升高至70℃，至丸剂充分干燥得到药丸；
(7)包装，备好无毒的塑料薄膜或皮纸，将制备好的药丸进行包裹。
实施例3
一种防治瘟疫的药丸，由主药剂和副药剂混合制成，其中主药剂按重量百分比由以下组分制成：川大黄5份，元参3份，紫苏3份，葛根3份，柴胡3份，香薷3份，藿香2份，枳壳2份，天花粉2份，赤芍1.5份，连翘2.5份，羌活2份，白芷2.5份，防风2份，荆芥2份，黄芩2份，威灵仙1份，细辛0.8份；副药剂按重量百分比由以下组分制成：青蒿汁4份，陈仓米4份。
上述防治瘟疫的药丸及其制备方法，包括如下步骤：
(1)药材磨粉，按照上述要求选用并称量制取主药剂的药材，然后磨成细度为100目的细粉，装入消毒盆中混匀备用，将陈仓米磨成100目的细粉，备用；
(2)制糊，称取纯水42份，按上述要求称量陈仓米粉，在纯水中加入称量好的陈仓米粉，搅拌混匀，并进行加热，在加热过程中进行搅拌，以避免糊底，煮沸后静置直到形成糨糊；
(3)捏合，将上述糨糊倒入步骤(1)所得的药粉中搅匀，并在搅拌的过程中，按照上述比例加入青蒿汁，在加入青蒿汁的同时用搅拌工具在药粉内朝同一方向圆周搅动，然后用手趁热用力搅拌捏合，制成丸块备用；
(4)搓条，将丸块用手或制丸板搓成长条状的丸条，以便进一步切割为丸剂，丸条的粗细按丸剂的大小而定，在搓条时在手或工具上擦抹润滑剂，以避免丸块粘在手上或工具上，所述润滑剂系麻油与黄蜡按3:1加热融合制成；
(5)成型，将丸条分割成等量的小粒，再用手或制丸板搓成圆形的丸剂；
(6)干燥，将步骤(5)制成的丸剂在50℃进行干燥，以免丸剂的表面发裂，至接近干燥时，温度升高至65℃，至丸剂充分干燥得到药丸；
(7)包装，备好无毒的塑料薄膜或皮纸，将制备好的药丸进行包裹。
以上所述，仅是本发明的较佳实施例而已，并非对本发明作任何形式上的限制，虽然本发明已以较佳实施例揭露如上，然而并非用以限定本发明，任何熟悉本专业的技术人员，在不脱离本发明技术方案范围内，当可利用上述揭示的技术内容作出些许更动或修饰为等同变化的等效实施例，但凡是未脱离本发明技术方案内容，依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰，均仍属于本发明技术方案的范围内。

Claims (3)

  1. 一种防治瘟疫的药丸，其特征在于：由主药剂和副药剂混合制成，其中主药剂按重量百分比由以下组分制成：川大黄4-6份，元参2-4份，紫苏2-4份，葛根2-4份，柴胡2-4份，香薷2-4份，藿香1-3份，枳壳1-3份，天花粉1-3份，赤芍1-2份，连翘2-3份，羌活1-3份，白芷2-3份，防风1-3份，荆芥1-3份，黄芩1-3份，威灵仙0.5-1.5份，细辛0.5-1份；副药剂按重量百分比由以下组分制成：青蒿汁3-5份，陈仓米3-5份。
  2. 根据权利要求1所述防治瘟疫的药丸的制备方法，其特征在于，包括如下步骤：
    (1)药材磨粉，按照权利要求1中的要求选用并称量制取主药剂的药材，然后磨成细度为80-120目的细粉，装入消毒盆中混匀备用，将陈仓米磨成80-120目的细粉，备用；
    (2)制糊，称取纯水40-45份，按权利要求1中的要求称量陈仓米粉，在纯水中加入称量好的陈仓米粉，搅拌混匀，并进行加热，在加热过程中进行搅拌，以避免糊底，煮沸后静置直到形成糨糊；
    (3)捏合，将上述糨糊倒入步骤(1)所得的药粉中搅匀，并在搅拌的过程中，按照权利要求1所述的比例加入青蒿汁，在加入青蒿汁的同时用搅拌工具在药粉内朝同一方向圆周搅动，然后用手趁热用力搅拌捏合，制成丸块备用；
    (4)搓条，将丸块用手或制丸板搓成长条状的丸条，以便进一步切割为丸剂，丸条的粗细按丸剂的大小而定，在搓条时在手或工具上擦抹润滑剂，以避免丸块粘在手上或工具上；
    (5)成型，将丸条分割成等量的小粒，再用手或制丸板搓成圆形的丸剂；
    (6)干燥，将步骤(5)制成的丸剂在45-55℃进行干燥，以免丸剂的表面发裂，至接近干燥时，温度升高至60-70℃，至丸剂充分干燥得到药丸；
    (7)包装，备好无毒的塑料薄膜或皮纸，将制备好的药丸进行包裹。
  3. 根据权利要求2所述用于防治瘟疫的药丸的制备方法，其特征在于：所述润滑剂系麻油与黄蜡按3:1加热融合制成。
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