WO2018208138A1 - Composition à base de plantes, son procédé d'obtention et d'utilisation - Google Patents

Composition à base de plantes, son procédé d'obtention et d'utilisation Download PDF

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Publication number
WO2018208138A1
WO2018208138A1 PCT/MK2018/000001 MK2018000001W WO2018208138A1 WO 2018208138 A1 WO2018208138 A1 WO 2018208138A1 MK 2018000001 W MK2018000001 W MK 2018000001W WO 2018208138 A1 WO2018208138 A1 WO 2018208138A1
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WO
WIPO (PCT)
Prior art keywords
herbal composition
composition according
total weight
extraction
skin
Prior art date
Application number
PCT/MK2018/000001
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English (en)
Inventor
Eftim ISIROV
Original Assignee
Isirov Eftim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of WO2018208138A1 publication Critical patent/WO2018208138A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Definitions

  • Herbal composition its procedure for obtaining and use is an invention in the field of human necessities, which is according to International Patent Classification in subfield health, in the class of medical and veterinary science and hygiene, in the group of preparations for medical purpose i.e. in the group of medical preparations containing herbal material i.e. traditional herbal medicines and the group of specific therapeutic activity of medical preparations.
  • this invention can be classified in the following classes: A61 K36:537, A61 K36:73, A61 K36:534, A61 K 36:894, A61 K 36:28, A61 K 127/00, A61 K 131/00, A61 P 9/14, A61 P 31/04, A61 P 37/04, A61 P 37/08, A61 P 31/12, A61 P 39/06, A61 P 31/16.
  • the preparation is a liquid solution (water extract) used as a dietary supplement and is intended for children and adults.
  • the active components of ingredients which are contained in this preparation are proven in medical science.
  • the invention mainly solves the problem of prevention and/or treatment of allergic diseases, acute and chronic sinusitis, improvement of the immunity and general health condition and the treatment of external and internal hemorrhoids.
  • the preparation has an anti-stress action i.e. anti-stress effect on the nervous system, helps psychological difficulties, tension, anxiety and fatigue.
  • the current state of the art is characterized by excessive use of drugs with synthetic origin for the treatment of various diseases and conditions of the organism.
  • this invention has a combination of six medicinal plants collected during various periods, mixed in appropriate proportion and extracted plant materials in order to prepare a combined preparation i.e. herbal composition.
  • This invention is composition of an extract of combined plant materials i.e. Sage (Salvia officinalis), Quince (Cydonia oblonga), Nettle (Urtica dioica), Mint (Mentha piperita), Japanese apple - Persimmon (Diospyros kaki), stevia extract and water as a solvent.
  • the proportion of Sage is 5-15% of the total weight of the preparation, 10-30% of quince (Cydonia oblonga) of the total weight, Nettle (Urtica dioica) 5-10% of the total weight, Mint (Mentha piperita) also 5-10% of the total weight, Japanese apple - Persimmon (Diospyros kaki) of 30-50% of the total weight, Stevia extract with 5-10% of the total weight and the rest is water up to 00 % of the total weight of the preparation.
  • synergy working together
  • Some classes of herbal components developed more expressed synergy among themselves and with other compounds.
  • the flavonoids are particularly important. They are present in many herbal medicines, i.e. in all the above mentioned plants and can interfere with other components in order to increase their activity with synergy or other mechanism.
  • the essential oils contained in the above plants can also act through synergy.
  • Salvia officinalis The name of the Sage (lat. Salvia officinalis) latin Salvia comes from the word that means the rescue and treatment as the old Romans used to treat various diseases. Salvia officinalis has medicinal leaves and young branches and the most healing leaf is obtained before blossom of the Sage in May. Main ingredient in the leaf of Sage is fragrant volatile essential oil which is from 1 .5 to 2.5%. The bitter taste and healing effect of the leaf comes from tannin. Ingredients
  • Tannin which strengthens the mucous membrane.
  • Essential oil has antiseptic effect.
  • Main ingredients of essential oils are Alpha and Beta tujon, camphor and cineol.
  • Flavonoids and phenolic acid which are acting antispasmodic, relieve the spasms of internal organs and regulate the secretion of bile.
  • vitamins A, B1 , B2, and C limonene, camphene, alpha pinene, borneol, beta-pinene and others.
  • Quince is one of low-calorie fruits, which in 100g contains only 57 calories.
  • Quince is rich in vitamins and minerals that are important for our organism: vitamin C, B1 , B2, B3, B6, niacin, carotene, calcium, magnesium, copper, sodium, potassium, zinc, iron, manganese, thiamine, riboflavin and pyridoxine.
  • Some sources state that the seeds of quince contain vitamin B17 which in many alternative circles is considered as one of most healing natural medicines against cancer. It also contains carbohydrates, fiber.
  • amygdalin, bioflavonoids, pectin and essential oils are important medicinal ingredients.
  • Quince has a long list of medical actions in inflammation of airways, viral and bacterial infections and in treating various skin conditions.
  • the leaf of quince is particularly effective in diarrhea and other stomach problems.
  • bark of quince can be used for preparation of tea.
  • Coatings of quince (fruit, bark, leaves) are used to treat wounds, burns, cracked skin or nipples.
  • the ingredients from Quince are used also in cosmetics.
  • Quince should be used as a medicament or as an auxiliary material in the following diseases:
  • the leaf of quince has healing properties in the treatment of the following conditions
  • Mint is a perennial herb with a strong odor.
  • the leaf of mint is most widely used and is best to be collected in early blooming.
  • the aromatic leaf of mint containing the most essential oils from which it comes healing effect and pleasant fragrance of this useful herb.
  • the raw material containing essential oils, tannins, flavonoids, bitter substances.
  • the essential oil containing menthol, mentolin, menthofuran, limonene, cineol and others. Due to its medicinal properties, the leaf and scent essential oil represent an important raw material for the production of a number of drugs, prophylactic, hygienic, dietetic, cosmetic, perfume and other products for a wide consumption worldwide.
  • the composition of mint are found vitamins, minerals, acids, beta-carotene and various fibers.
  • Mint is commonly used to treat digestive problems and abdominal pain. Peppermint essential oil relaxes the stomach and intestines, the occurrence of excess air - air in the stomach - belching, regulates digestion.
  • Mint is a medicament for the trembling of the colon, irritable bowel symptoms that occur due to psychological pressures and stress that further irritate the digestive tract.
  • Mint affect the regulation of rapid heart rate, relaxes bronchi and relieves the symptoms of asthma. Mint is an active agent against bad breath, gum disease and tooth decay in the form of solution for mouth rinse. It possesses antiseptic and antibacterial properties.
  • Mint has an effect as a natural remedy for calming the stomach i.e. cramps and bloating. Mint calms the stomach and intestines and is used for gastritis and colitis.
  • ⁇ breathing organs Thanks to methanol, mint cleans roads for breathing. It is recommended for colds, flu or at high temperature.
  • bronchitis The presence of acetic acid and ascorbic acid in mint helps decomposition of the mucus which contributes to the ejection of mucus from the lungs.
  • peppermint oil is often used to relieve pain in people who suffer from rheumatism.
  • kidney stones There are beliefs that healing properties of mint tea could prevent kidney stones.
  • Nettle is used as medicine and food long time ago, and its healing properties today are irreplaceable. According to many experts the nettle is the most valuable plant in the world, because its composition is a cure for many diseases. Although the leaves bum and pierce the skin, the dark green leaves of the nettle by boiling become soft and therapeutic, and similar properties have roots and seeds. This herb is very widespread. It is best when the leaves are collected in the spring. Because of the vitamin and nutritional values nettle is considered as very useful plant. Ingredients
  • Major actions of nettle are hemostatic, astringent, roborant and diuretic effect.
  • Nettle is most known for that it contains iron, but has the status of an unchallenged fighter against anemia. This disease most often occurs in children, pregnant women and the elderly, lack of this mineral in the blood, is difficult to compensate with food. To avoid the use of various pills and supplements, most efficient is to use nettle as a means for improving and combating anemia.
  • Nettle is one of the most nutritious plants distributed in nature and the human environment.
  • nettle is a natural cleaner of the body, it can be said it is a diuretic, which positively affects the health of the kidneys, bladder and urethra. This has enormous benefits for the whole body, because it slightly increases the secretion and discharge of urine. In this way excess of uric acid from the body is removed. Also, prevents from urinary tract infections, edema, arthritis and gout. The beneficial effects of nettle
  • Nettle is the best natural means for cleaning the blood. Nettle containing large amounts of vitamin A, various mineral salts, plant hormones and enzymes that affect beneficially on increasing of the number of red blood cells in the blood. Nettle improves the work of the digestive system. It is used often as a natural remedy for constipation. Nettle strengthens the natural immunity of the organism, so often it is used in rheumatic diseases and gout, as well as colds and reduced immunity.
  • the tea from leaves of the Japanese apple containing various variants of vitamin C, B2, B9 and other B vitamins, vitamin E, K, beta-carotene, as well as various minerals such as magnesium, manganese, titanium, calcium, phosphorus, potassium, organically bound iron, copper and phosphorus.
  • various minerals such as magnesium, manganese, titanium, calcium, phosphorus, potassium, organically bound iron, copper and phosphorus.
  • tannins, flavone, rutin, choline, carotene essential amino acids.
  • Persimmon leaves are rich in fiber and contain tannins that help with digestion (digestion). They also have properties that help in the prevention of high blood pressure.
  • Japanese persimmon is very noble plant. Fresh fruit or juice of Japanese apple is useful for the treatment of constipation and intestinal inflammation, hemorrhoids, stomach disorders and may help high blood pressure.
  • Japanese apples are rich in flavonoids, especially Quercetin, because it reduces the risk of heart attack and heart disease. At the same time assists in protecting the body from the damaging effects of free radicals.
  • Improvement of the immunity - vitamin C in leaves of Persimmon helps in the production of white blood cells acting as a protective shield against bacterial, viral and toxic elements and boost immunity. Strong antioxidant capacity contributes a lot to improve overall health.
  • Anticancer effect while antioxidants in persimmon not contribute to the fight against free radicals, betulinic acid is known for its anti-carcinogenic properties, preventing growth and reducing cancerous tumors. • For allergy - persimmon enriched with Astralgin and other anti-allergic flavonoids prevents the release of histamine and reduce allergy and inflammation.
  • the preparation containing natural antibiotics which instantly affect bacterial, fungal and viral infections. Due to its antiseptic and antibacterial characteristics is useful for external use for problems and unpleasant appearing on the skin, for various injuries to the skin, itching and skin irritation. It has a calming and beneficial effect in bronchitis, cough, urinary infections, asthma, sinus inflammation, acute and chronic sinusitis, colds, cardiovascular diseases, severe headaches, inflammatory bowel disease and treatment of internal and external hemorrhoids.
  • This composition has preventive use i.e. guards and purify the body from harmful substances, acts as a strong antioxidant, improves elasticity of blood vessels, reduces fat and cholesterol in hypercholesterolemia, reduces blood sugar in diabetes and high blood pressure in hypertension, improves blood and has a positive influence in the direction of improving the immune system and general health.
  • the invention has an excellent laxative properties, has a positive impact in the regulation of the stool and reduce excess weight.
  • Active anti-allergens give excellent result in pollen, seasonal allergies, urticarial, and pesky allergies from animal origin.
  • Anti- stress action i.e. anti-stress effect on the nervous system helps with psychological difficulties, tension, anxiety and fatigue.
  • Raw material is collected and prepared according to specific method at a time convenient for certain plant and in places, regions in Ravena which are clean and unpolluted.
  • Adequate drying is the most important phase in the process of production of herbal drugs. Drying the leaves is carried out in the shadow of clean paper or cloth in a well ventilated room at a temperature no higher than 40 degrees.
  • Extracts are pharmaceutical herbal preparations derived from dry or fresh plant material, using a suitable extractable process.
  • Each drug before use, respectively further processing, must be identified, evaluated in terms of cleanliness of the molds, insects, other organic and inorganic impurities (parts of other plants, parts of the non-drug plant itself, soil and so on. ) and it should be properly cleaned.
  • the drug must be properly protected to prevent changes in the active principles.
  • Dry drug before use in the preparation of extracts or tinctures should be moisturized with a suitable solvent (menstruum) and to stay for half an hour to several hours or even days, depending on the plant material.
  • a suitable solvent Menstruum
  • Moisturizing (softening) of the drug is a type of maceration which is carried out at room temperature, namely it is the extraction thereby the solvent enters into the cell structures of drugs and active principles are dissolved. Moisturizing is done in glass or steel containers, properly closed, with occasional stirring. Extractable overall process depends primarily on the degree of fragmentation of the drug and the choice of extractive agent. Extractive means should allow maximum extraction of the desired active principles and prevent the extraction of undesirable components.
  • the extracts are commonly prepared in two successive stages, particularly solid (dry extracts).
  • the first stage involves the extraction of active principles followed by partial or complete pairing and getting concentrated product.
  • the liquid extracts are prepared so that a portion of extract corresponds to a portion of the drug (1 : 1 ). They are prepared by moisturizing (lat.maceration) of the drug and then percolation (lat.percolatio). In percolation the solvent flow through the drug which is placed in a glass cylinder or another cylinder of inert material. The percolation material is collected dropwise to obtain 85% of the final volume. The other 5% are obtained by extraction of moisturized plant material.
  • Liquid extracts can be used in the form of drops, liquid for drinking, spray or other dosage forms.
  • the extraction procedure with ultrasound is mechanical extraction whereby are obtained extract active ingredients from medicinal plants and a high quality phyto extracts.
  • This technology is considered to be biological because it eliminates the use of non-natural solvents and it is a technology for organic products.
  • Extraction with ultrasound is extraction with a sound of low frequency and high energy that transforms electrical energy into mechanical vibrations.
  • This invention is an extract liquid obtained by dissolving the semi-solid and solid extracts in water as a solvent, it must therefore be applied, the procedure of mechanical separation of solid and liquid phase, i.e. to apply filtering.
  • This invention depending on the method of use can be packaged in the form of liquid as a drink, in the form of spray, applicators and drops.
  • the herbal composition according to the method of use may be administered orally, nasally, intra-anal and topical.
  • Packaging form of the liquid as a drink in glass bottles (Recycling plastic) is particularly 250-500 ml or 50 ml bottles for improving the immune system and general health. Drink 2 times per day for 15 ml. For problems and unpleasant appear on the skin can be used in the form of coatings.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Selon la présente invention, la composition à base de plantes comprend une composition de l'extrait à partir de matériels végétaux combinés dans des pourcentages appropriés sur la base de la masse totale du mélange, les matériels végétaux étant choisis dans le groupe constitué par la sauge (Salvia officinalis), le cognassier (Cydonia oblonga), l'ortie (Urtica dioica), la menthe (Mentha piperita), le plaqueminier du Japon - kaki (Diospyros kaki), de l'extrait de stevia et de l'eau en tant que solvant. La présente invention concerne également un procédé d'obtention de la composition à base de plantes comprenant la collecte et la préparation de matières premières, la préparation et l'extraction des principes actifs, le filtrage et l'emballage. L'extraction des principes actifs est effectuée par extraction par ultrasons, l'eau étant utilisée comme solvant. La présente invention concerne également l'utilisation de la composition à base de plantes avec un effet antiallergique, antibactérien, antiviral, antioxydant et antistress. L'invention résout principalement le problème du traitement prophylactique et/ou thérapeutique de maladies allergiques, de la sinusite aiguë et chronique, de l'amélioration de l'immunité et de la santé générale et du traitement des hémorroïdes externes et internes.
PCT/MK2018/000001 2017-05-08 2018-05-07 Composition à base de plantes, son procédé d'obtention et d'utilisation WO2018208138A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MK733917 2017-05-08
MKMK/P/2017/339 2017-05-08

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WO2018208138A1 true WO2018208138A1 (fr) 2018-11-15

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3795163A1 (fr) * 2019-09-23 2021-03-24 The Ceutics Company GesmbH Formulation topique d'extrait de plante comprenant d'urtica dioica et de vitamine a

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EP2022504A1 (fr) * 2007-08-08 2009-02-11 Feyyaz Dr. Kücükay Onguent pour le traitement d'hémorroïdes
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US8414935B2 (en) * 2009-02-25 2013-04-09 Byzmed Llc Composition and methods for clotting blood
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EP2022504A1 (fr) * 2007-08-08 2009-02-11 Feyyaz Dr. Kücükay Onguent pour le traitement d'hémorroïdes
CN101313933A (zh) * 2008-06-30 2008-12-03 李允科 一种治疗痔疮外用药
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US8414935B2 (en) * 2009-02-25 2013-04-09 Byzmed Llc Composition and methods for clotting blood
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DORMAN H J D ET AL: "ANTIOXIDANT PROPERTIES AND COMPOSITION OF AQUEOUS EXTRACTS FROM MENTHA SPECIES, HYBRIDS, VARIETIES, AND CULTIVARS", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, BOOKS AND JOURNALS DIVISION, US, vol. 51, no. 16, 1 January 2003 (2003-01-01), pages 4563 - 4569, XP008065639, ISSN: 0021-8561, DOI: 10.1021/JF034108K *
GULCIN ILHAMI ET AL: "Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.)", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 90, no. 2-3, 1 February 2004 (2004-02-01), pages 205 - 215, XP002420244, ISSN: 0378-8741, DOI: 10.1016/J.JEP.2003.09.028 *
OLLANKETO M ET AL: "Extraction of sage (Salvia officinalis L.) by pressurized hot water and conventional methods: antioxidant activity of the extracts", EUROPEAN FOOD RESEARCH AND TECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 215, no. 2, 1 January 2002 (2002-01-01), pages 158 - 163, XP002429118, ISSN: 1438-2377, DOI: 10.1007/S00217-002-0545-7 *
PERICHE ANGELA ET AL: "Influence of Extraction Methods on the Yield of Steviol Glycosides and Antioxidants inStevia rebaudianaExtracts", PLANTS FOODS FOR HUMAN NUTRITION, KLUWER ACADEMIC PUBLISHERS, NL, vol. 70, no. 2, 1 March 2015 (2015-03-01), pages 119 - 127, XP035497161, ISSN: 0921-9668, [retrieved on 20150301], DOI: 10.1007/S11130-015-0475-8 *
S. FATTOUCH ET AL: "Comparative Analysis of Polyphenolic Profiles and Antioxidant and Antimicrobial Activities of Tunisian Pome Fruit Pulp and Peel Aqueous Acetone Extracts", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 56, no. 3, 1 February 2008 (2008-02-01), US, pages 1084 - 1090, XP055498155, ISSN: 0021-8561, DOI: 10.1021/jf072409e *
YOUN UN-YOUNG ET AL: "Antioxidant activity of water extracts of persimmon flower buds", FOOD SCIENCE AND BIOTECHNOLOGY, THE KOREA SOC. OF FOOD SCIENCE AND TECHNOLOGY, HEIDELBERG, vol. 24, no. 1, 28 February 2015 (2015-02-28), pages 281 - 286, XP035421141, ISSN: 1226-7708, [retrieved on 20150228], DOI: 10.1007/S10068-015-0037-8 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3795163A1 (fr) * 2019-09-23 2021-03-24 The Ceutics Company GesmbH Formulation topique d'extrait de plante comprenant d'urtica dioica et de vitamine a
WO2021058521A1 (fr) 2019-09-23 2021-04-01 The Ceutics Company Gesmbh Formulation topique à base d'extrait de plante comprenant de l'urtica dioica et de la vitamine a

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