WO2018203380A1

WO2018203380A1 - Brown algae extract-containing composition, and brown algae extract-containing hemorrhoid treatment and prevention liquid

Info

Publication number: WO2018203380A1
Application number: PCT/JP2017/017208
Authority: WO
Inventors: 増村光一郎; 黒部耕司
Original assignee: ラムズ・マークス株式会社
Priority date: 2017-05-01
Filing date: 2017-05-01
Publication date: 2018-11-08

Abstract

The present invention realizes a brown algae extract-containing composition that at least contains a brown algae extract as an active ingredient and that is able to prevent induction of a hemorrhoid disease and promote improvement in a case where a hemorrhoid disease develops. The brown algae extract-containing composition includes, as a main ingredient, a brown algae extract in which the solid content excluding the moisture content accounts for 0.10-10.00 wt%, and includes, as the remaining ingredients, water, ethanol, and the like, and contains medically allowable ingredients. The remaining ingredients at least contain 0.10-10.00 wt% of an anti-inflammatory agent, 0.20-10.00 wt% of an aloe extract, and 0.10-5.00 wt% of a soluble protein component.

Description

Brown algae extract-containing composition and brown algae extract-containing acupuncture prevention liquid

The present invention relates to a gel-like or liquid brown algae extract-containing composition containing a brown algae extract as a main component, and a brown algae extract-containing acupuncture prevention liquid.

The recent widespread use of toilet seats and toilets with a hot water washing function has contributed to the prevention and improvement of manic diseases. This is because removal of stool with dust paper or toilet paper is accompanied by friction on the perianal area and the affected area, which may cause a manic disease or worsen the manic disease.

痔 When a manic disease develops, it is generally embarrassed to go to the hospital because the diseased part is the anus, and it is common to deal with a commercially available medicine for manic diseases. As an external medicine for treating hemorrhoid disease, for example, (a) 0.01 to 0.3% by mass of a refreshing agent, (b) 0.1 to 10% by mass of a gelling agent, and (c) 1 alcohol. An agent for treating gel-like hemorrhoids containing 10 to 10% by mass, (d) 50 to 98% by mass of water, and (e) 3% by mass or less of a local anesthetic is disclosed (see Patent Document 1).

JP 2012-25771 A

By the way, commercially available drugs for treating hemorrhoids include local anesthetic components such as lidocaine and dibucaine as described in Patent Document 1, and those that temporarily relieve pain, and refresher components such as menthol and camphor. There are those that have the effect of temporarily relieving itching of manic diseases.

However, a local anesthetic component or a refreshing agent component temporarily removes discomfort of a manic disease such as pain and itch, but cannot be an active ingredient for preventing or treating manic disease. Therefore, these drugs for treating hemorrhoids are only used as coping therapy drugs, and eventually, when the hemorrhoids worsen, there is a current situation in which surgical treatment is unavoidable by anal surgery or the like.

The present invention was devised in view of the above circumstances, and contains a brown alga extract-containing composition containing at least a brown algae extract as an active ingredient in order to prevent the induction of an epilepsy disease or to improve an epilepsy disease, and The purpose is to provide a brown algae extract-containing acupuncture prevention liquid.

In order to achieve the above object, the brown algae extract-containing composition according to the present invention comprises a brown algae extract having a solid content of 0.10 to 10.00% by weight excluding moisture as a main component, and is medically acceptable as a remaining component. It is characterized by containing various components. Brown algae extract contains fucoidan, amino acid, diastase, alginic acid, and abundant minerals, and has been reported to have external effects such as moisturizing action and skin regenerating action. Therefore, the reason why the brown algae extract is a main component is that external effects such as a moisturizing action and a skin regenerating action are active ingredients for leprosy. The remaining components include water, ethanol and the like and are medically acceptable components.

The reason why the brown algae extract is contained in a solid content of 0.10% by weight or more is that if it is less than 0.10%, a sufficient effect as an active ingredient of a manic disease cannot be obtained. On the other hand, the brown algae extract is contained in an amount of 10.00% by weight or less as the solid content because if it exceeds 10.00% by weight, it is difficult to adjust the remaining components.

The solid content of the brown algae extract is preferably 0.10 to 3.00% by weight. The reason why the solid content of the brown algae extract is set in the range of 0.10 to 3.00% by weight is that a particularly effective effect is obtained in this range.

The remaining component comprises at least 0.10 to 10.00% by weight of anti-inflammatory agent, 0.20 to 10.00% by weight of aloe extract, and 0.10 to 5.00% by weight of soluble protein component. It is preferable to contain. The reason for containing the anti-inflammatory agent is to suppress inflammation of the manic disease. The reason for containing 0.10% by weight or more of the anti-inflammatory agent is that if it is less than 0.10% by weight, it is difficult to obtain anti-inflammatory effects. The reason why the anti-inflammatory agent is contained in an amount of 10.00% by weight or less is that when the amount exceeds 10.00% by weight, no difference is observed in the anti-inflammatory effect.

Aloe extract contains plant phenolic components such as aloin, polysaccharides components such as aloe mannan and gluconic acid, and other components such as aloetin, and also contains brown algal extract. It is because it can become an active ingredient.

Plant phenolic components have been reported to have external effects such as sedation and analgesia, bacterial growth inhibition, and enzyme activity suppression. In addition, external effects such as skin beautification, wound healing, anti-inflammatory and sterilization have been reported for polysaccharide components. Furthermore, as other ingredients, it has been reported that aloetin has a strong antibacterial and antifungal effect for external use.

The reason why the aloe extract is contained by 0.20% by weight or more is that if it is less than 0.20% by weight, it is difficult to obtain an effect as an active ingredient. The reason why Aloe extract is contained in an amount of 10.00% by weight or less is that no difference is observed in the efficacy as an active ingredient even if the amount exceeding 10.00% by weight is added.

The reason why the soluble protein component is contained is to promote the penetration into the skin. The reason why the soluble protein component is contained in an amount of 0.10% by weight or more is that the permeability to the skin is inferior when the content is less than 0.10% by weight. On the other hand, the reason why the soluble protein component is contained at 5.00% by weight or less is that no difference is observed in the permeability to the skin even if an amount exceeding 5.00% by weight is added.

The anti-inflammatory agent preferably contains at least one of glycyrrhizic acid 2K and allantoin. The reason why the anti-inflammatory agent contains at least one kind of glycyrrhizic acid 2K and allantoin is that an anti-inflammatory effect can be obtained by including any of these components. In order to enhance the efficacy of anti-inflammatory, it is preferable to use a combination of a plurality of components.

The aloe extract preferably contains at least one kind of aloe vera mesophyll, kidachi aloe mesophyll, cape aloe mesophyll, aloe vera leaf extract, kidachi aloe leaf extract, cape aloe leaf extract. The aloe extract contains at least one of aloe vera mesophyll, kidachi aloe mesophyll, cape aloe mesophyll, aloe vera leaf extract, kidachi aloe leaf extract, cape aloe leaf extract. It is because the effect as is obtained. In order to increase the efficacy as an active ingredient, it is preferable to use a combination of a plurality of ingredients.

The soluble protein component is preferably hydrolyzed silk. By using hydrolyzed silk as the soluble protein component, good permeability to the skin can be ensured.

The brown algae extract-containing acupuncture prevention liquid according to the present invention is characterized in that the brown algae extract-containing composition according to any one of the above is used as a treatment prevention liquid for an epilepsy disease. By using the brown algae extract-containing composition according to any of the above as a treatment / prevention solution for hemorrhoid disease, induction of hemorrhoid disease can be prevented, and improvement is promoted even when epilepsy disease has developed. Can do.

According to the brown algae extract-containing composition according to the present invention, it contains at least a brown algae extract as an active ingredient, and can prevent the induction of epilepsy disease or promote improvement even if it has developed epilepsy disease. Demonstrate the excellent effect of being able to.

It is explanatory drawing which shows the result of the efficacy confirmation test of Examples 1-5 and Comparative Examples 1-3. It is explanatory drawing which shows the result of the efficacy confirmation test of Examples 6-10 and Comparative Examples 4-6. It is explanatory drawing which shows the result of the efficacy confirmation test of Examples 11-15 and Comparative Examples 7-9. It is explanatory drawing which shows the result of the efficacy confirmation test of Examples 16-20 and Comparative Examples 10-12. It is a schematic diagram of the state outside a test subject's anal part. It is a classification | category figure of the state of the anal part of a test subject before treatment prevention liquid use. It is a classification figure of a test subject's use frequency. It is a classification diagram of a test subject's use period. It is a classification | category figure of the state of the anal part of a test subject after treatment prevention liquid use.

Hereinafter, the brown algae extract-containing composition and the brown algae extract-containing wrinkle healing preventing liquid according to the present embodiment will be described with reference to examples. In the following description, the drawings are schematically shown.
[Brown algae extract-containing composition]

The brown algae extract according to the present embodiment is an extract extracted from brown algae such as mozuku, wakame and kelp. Seaweeds include green algae, brown algae, and red algae. In this embodiment, it is particularly preferable to use an extract of brown algae. The extraction method of the brown algae extract is not limited, but it is preferable to remove harmful low-molecular substances such as arsenic. Therefore, although it is preferable to use a high molecular weight extract as the brown algae extract, it is not limited to this.

Brown algae extract contains fucoidan, amino acid, diastase, alginic acid, and abundant minerals, and has been reported to have external effects such as moisturizing action and skin regenerating action. In particular, fucoidan, a sulfated polysaccharide composed mainly of full-course sugar, has antitumor, anti-gastric ulcer, antiviral, anti-inflammatory, anticoagulant, immune enhancement, anti-type I allergy, antihyperlipidemia, etc. It has been reported to have various pharmacological actions (JP 2002-220402 A). Fucoidan is also used as a moisturizing ingredient in cosmetics and the like. Therefore, the brown algae extract-containing composition according to the present embodiment has the brown algae extract as a main component because external effects such as a moisturizing action and a skin regenerating action are effective ingredients for leprosy.

The brown algae extract-containing composition according to the present invention comprises a brown algae extract having a solid content of 0.10 to 10.00% by weight excluding moisture as a main component, and a medically acceptable component such as water or ethanol as a remaining component. contains. The remaining components include at least 0.10 to 10.00% by weight of anti-inflammatory agent, 0.20 to 10.00% by weight of aloe extract (aloe leaf meat powder and / or aloe leaf extract), and 0 It is preferable to contain 10 to 5.00% by weight of a soluble protein component. The solid content of the brown alga extract is preferably 0.10 to 3.00% by weight.

In order to examine the optimal content of the solid content of the brown algae extract, the anti-inflammatory agent, the aloe extract, and the soluble protein component constituting the brown algae extract-containing composition according to the present embodiment, the following Examples 1 to 20, comparison Efficacy confirmation tests were conducted with combinations of the contents of Examples 1-12.

In Examples 1 to 20 and Comparative Examples 1 to 12, the efficacy confirmation test was performed once a day on the anus of multiple (same number) subjects, and the use of a brown alga extract-containing composition for symptoms of hemorrhoid disease Judgment was made based on feeling. In Examples 1 to 20 and Comparative Examples 1 to 12, only the feeling of use was confirmed in order to examine the optimum content of the solid content of the brown algae extract, the anti-inflammatory agent, the aloe extract, and the soluble protein component. We have not confirmed the improvement effect for the symptoms of hemorrhoid diseases (warts, cuts, pain, itching, bleeding, etc.).
Improvement of all symptoms: ◎
Improvement of any of the symptoms: ○
消失 Disappearance of disease discomfort: △
Continuation of symptoms of hemorrhoid disease: ×

First, in order to examine the optimal content of brown algae extract, efficacy confirmation tests were performed using combinations of the contents of Examples 1 to 5 and Comparative Examples 1 to 3. FIG. 1 shows the results of efficacy confirmation tests of Examples 1 to 5 and Comparative Examples 1 to 3.

In FIG. 1, the solid content of the brown algae extract as the main component is changed in the range of 0.5 to 15.0% by weight, and the remaining amount contains purified water and absolute ethanol. The composition of the brown algae extract-containing composition of Example 1 is as follows.
Example 1
Solid content of brown algae extract: 0.10% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Example 2 is as follows.
(Example 2)
Solid content of brown algae extract: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Example 3 is as follows.
(Example 3)
Solid content of brown algae extract: 5.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Example 4 is as follows.
Example 4
Solid content of brown algae extract: 10.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Example 5 is as follows.
(Example 5)
Solid content of brown algae extract: 15.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Comparative Example 1 is as follows.
(Comparative Example 1)
Solid content of brown algae extract: 0.05% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Comparative Example 2 is as follows.
(Comparative Example 2)
Solid content of brown algae extract: 0.08% by weight
Purified water and absolute ethanol: remaining

In FIG. 1, the composition of the brown algae extract-containing composition of Comparative Example 3 is as follows.
(Comparative Example 3)
Solid content of brown algae extract: 0.09 wt%
Purified water and absolute ethanol: remaining

As shown in FIG. 1, in Examples 1 and 2, all the symptoms were improved: ◎ results were obtained. Also in Examples 3 to 5, the improvement of any of the symptoms: results of ◯ were obtained. However, in Comparative Example 3 and Comparative Example 2, the result of disappearance of the discomfort of the hemorrhoid disease: Δ was observed, but in Comparative Example 1, the continuation of symptoms of the hemorrhoid disease: the result of x.

That is, according to the brown algae extract-containing compositions of practical examples 1 to 5, by containing the solid content of the brown algae extract as the main component in the range of 0.10 to 15.00% by weight, the effect of improving the hemorrhoid disease Was confirmed. Further, it was confirmed that the solid content of the brown algae extract is more preferably in the range of 0.10 to 3.00% by weight. However, the solid content of the brown algae extract is preferably set to 10.00 weight or less. Even if the solid content of the brown algae extract as the main component exceeds 10.00% by weight, there is no difference in the efficacy of the active ingredient, and if it exceeds 10.00% by weight, it will be difficult to adjust the remaining components described later. is there.

Next, the solid content of the brown algae extract as the main component is appropriately set in the range of 0.05 wt% to 10.0 wt%, and the anti-inflammatory agent, aloe extract, and soluble protein component as the remaining components The content was examined.

First, in order to examine the optimum content of the anti-inflammatory agent, efficacy confirmation tests were conducted using combinations of the contents of Examples 6 to 10 and Comparative Examples 4 to 6. FIG. 2 shows the results of the efficacy confirmation tests of Examples 6 to 11 and Comparative Examples 4 to 6.

In FIG. 2, the solid content of the brown algae extract as the main component is appropriately set in the range of 0.05 to 10.0% by weight, and the anti-inflammatory agent is in the range of 0.05 to 15.0% by weight. The content is changed, and the remaining amount contains purified water and absolute ethanol. Further, the amount of aloe extract is set to 0% or 5.0% by weight, and the amount of soluble protein is set to 0% or 3.0% by weight. The composition of the brown algae extract-containing composition of Example 6 is as follows.
(Example 6)
Solid content of brown algae extract: 0.10% by weight
Anti-inflammatory agent: 0.10% by weight
Aloe extract: 5.0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Example 7 is as follows.
(Example 7)
Solid content of brown algae extract: 3.0% by weight
Anti-inflammatory agent: 0.50% by weight
Aloe extract: 0% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Example 8 is as follows.
(Example 8)
Solid content of brown algae extract: 5.0% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Example 9 is as follows.
Example 9
Solid content of brown algae extract: 10.0% by weight
Anti-inflammatory agent: 10.0% by weight
Aloe extract: 0% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Example 10 is as follows.
(Example 10)
Solid content of brown algae extract: 10.0% by weight
Anti-inflammatory agent: 15.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Comparative Example 4 is as follows.
(Comparative Example 4)
Solid content of brown algae extract: 0.05% by weight
Anti-inflammatory agent: 0.05% by weight
Aloe extract: 0% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Comparative Example 5 is as follows.
(Comparative Example 5)
Solid content of brown algae extract: 0.08% by weight
Anti-inflammatory agent: 0.08% by weight
Aloe extract: 5.0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 2, the composition of the brown algae extract-containing composition of Comparative Example 6 is as follows.
(Comparative Example 6)
Solid content of brown algae extract: 0.09 wt%
Anti-inflammatory agent: 0.09% by weight
Aloe extract: 0% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

As shown in FIG. 2, in Examples 6 to 10, all the symptoms were improved: A, or any of the symptoms was improved: A result was obtained. However, in Comparative Examples 5 and 6, the disappearance of the discomfort of the mania disease: a result of Δ was observed, but in Comparative Example 4, the continuation of symptoms of the mania disease: the result of ×.

That is, it was confirmed that the anti-inflammatory agent contained in the range of 0.10 to 15.0% by weight was effective in improving hemorrhoid disease. However, even if it contains more than 10.0% by weight of anti-inflammatory agent, there is no difference in anti-inflammatory efficacy, so the anti-inflammatory agent should be set in the range of 0.10 to 10.0% by weight. Is preferred. In addition, it is preferable that an anti-inflammatory agent contains at least 1 sort (s) of glycyrrhizic acid 2K and allantoin, for example. Examples of anti-inflammatory agents include glycyrrhizic acid 2K and allantoin, but are not limited to these exemplified agents, and are not intended to exclude other anti-inflammatory agents such as aminosalicylic acid and difuranisal. In order to increase the efficacy of anti-inflammatory, it is preferable to use a combination of a plurality of components in the range of 0.10 to 10.00% by weight.

Secondly, in order to examine the optimal content of the aloe extract, efficacy confirmation tests were conducted using combinations of the contents of Examples 11 to 15 and Comparative Examples 7 to 9. FIG. 3 shows the results of efficacy confirmation tests of Examples 11 to 15 and Comparative Examples 7 to 9.

In FIG. 3, the solid content of the brown algae extract as the main component is appropriately set in the range of 0.05 wt% to 10.0 wt%, and the aloe extract is set in the range of 0.05 to 15.0 wt%. The content is changed, and the remaining amount contains purified water and absolute ethanol. The compounding amount is set to 0% or 5.0% by weight for the anti-inflammatory agent and 0% or 3.0% by weight for the soluble protein. The composition of the brown algae extract-containing composition of Example 11 is as follows.
(Example 11)
Solid content of brown algae extract: 0.10% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 0.20% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Example 12 is as follows.
(Example 12)
Solid content of brown algae extract: 3.0% by weight
Anti-inflammatory agent: 0% by weight
Aloe extract: 3.0% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Example 13 is as follows.
(Example 13)
Solid content of brown algae extract: 5.0% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Example 14 is as follows.
(Example 14)
Solid content of brown algae extract: 10.0% by weight
Anti-inflammatory agent: 0% by weight
Aloe extract: 10.0% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Example 15 is as follows.
(Example 15)
Solid content of brown algae extract: 10.0% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 15.0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Comparative Example 7 is as follows.
(Comparative Example 7)
Solid content of brown algae extract: 0.05% by weight
Anti-inflammatory agent: 0% by weight
Aloe extract: 0.05% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Comparative Example 8 is as follows.
(Comparative Example 8)
Solid content of brown algae extract: 0.08% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 0.08% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 3, the composition of the brown algae extract-containing composition of Comparative Example 9 is as follows.
(Comparative Example 9)
Solid content of brown algae extract: 0.09 wt%
Anti-inflammatory agent: 0% by weight
Aloe extract: 0.10% by weight
Soluble protein: 0% by weight
Purified water and absolute ethanol: remaining

As shown in FIG. 3, in Examples 11 to 15, the results of improvement of all symptoms: ◎ or improvement of any symptom: ○ were obtained. However, in Comparative Examples 8 and 9, although the result of disappearance of discomfort of epilepsy disease: Δ was seen, in Comparative Example 7, the result of continuation of symptoms of epilepsy disease: x.

That is, it was confirmed that the aloe extract contained in the range of 0.20 to 15.00% by weight was effective in improving hemorrhoid disease. However, even if the aloe extract contains more than 10.0% by weight, there is no difference in the efficacy of the aloe extract, so the aloe extract should be set in the range of 0.20 to 10.0% by weight. Is preferred. In addition, it is preferable that an aloe extract contains at least 1 sort (s), for example, an aloe vera mesophyll powder, Kidachi aloe mesophyll powder, a cape aloe mesophyll powder, an aloe vera leaf extract, a Kidachi aloe leaf extract, and a cape aloe leaf extract. In order to increase the efficacy as an active ingredient, it is preferable to use a combination of a plurality of aloe extract components in the range of 0.20 to 10.00% by weight.

Thirdly, in order to examine the optimum content of soluble protein, efficacy confirmation tests were performed with combinations of the contents of Examples 16 to 20 and Comparative Examples 10 to 12. FIG. 4 shows the results of the efficacy confirmation test of Examples 16 to 20 and Comparative Examples 10 to 12.

In FIG. 4, the solid content of the brown alga extract as the main component is appropriately set in the range of 0.05% to 10.0% by weight, and the soluble protein is contained in the range of 0.05 to 10.0% by weight. The amount is varied and the remaining amount contains purified water and absolute ethanol. The compounding amount is set to 0% by weight or 5.0% by weight for the anti-inflammatory agent and 0% by weight or 5.0% by weight for the aloe extract. The composition of the brown algae extract-containing composition of Example 16 is as follows.
(Example 16)
Solid content of brown algae extract: 0.10% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 0.10% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Example 17 is as follows.
(Example 17)
Solid content of brown algae extract: 3.0% by weight
Anti-inflammatory agent: 0% by weight
Aloe extract: 0% by weight
Soluble protein: 3.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Example 18 is as follows.
(Example 18)
Solid content of brown algae extract: 5.0% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 5.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Example 19 is as follows.
(Example 19)
Solid content of brown algae extract: 10.0% by weight
Anti-inflammatory agent: 0% by weight
Aloe extract: 0% by weight
Soluble protein: 6.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Example 20 is as follows.
(Example 20)
Solid content of brown algae extract: 10.0% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 10.0% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Comparative Example 10 is as follows.
(Comparative Example 10)
Solid content of brown algae extract: 0.05% by weight
Anti-inflammatory agent: 0% by weight
Aloe extract: 0% by weight
Soluble protein: 0.05% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Comparative Example 11 is as follows.
(Comparative Example 11)
Solid content of brown algae extract: 0.08% by weight
Anti-inflammatory agent: 5.0% by weight
Aloe extract: 5.0% by weight
Soluble protein: 0.08% by weight
Purified water and absolute ethanol: remaining

In FIG. 4, the composition of the brown algae extract-containing composition of Comparative Example 12 is as follows.
(Comparative Example 12)
Solid content of brown algae extract: 0.09 wt%
Anti-inflammatory agent: 0% by weight
Aloe extract: 0% by weight
Soluble protein: 0.09% by weight
Purified water and absolute ethanol: remaining

As shown in FIG. 4, in Examples 16 to 20, results of improvement of all symptoms: ◎ or improvement of any symptom: ○ were obtained. However, in Comparative Examples 11 and 12, the disappearance of the discomfort of the manic disease was observed as a result of Δ, but in Comparative Example 10, the continuation of symptoms of the manic disease was a result of ×.

That is, it was confirmed that the soluble protein contained in the range of 0.10 to 10.00% by weight was effective in improving manic diseases. However, even if the soluble protein exceeds 5.0% by weight, there is no difference in the efficacy of the soluble protein. Therefore, the soluble protein is preferably set in the range of 0.10 to 5.0% by weight. In addition, although it is preferable that a soluble protein is a hydrolysis silk, for example, it is not the meaning which excludes soluble proteins other than the illustrated hydrolysis silk.
[Brown algae extract-containing disease treatment prevention solution]

Moreover, the brown algae extract-containing composition according to the present embodiment can be used as a treatment / prevention solution for hemorrhoid diseases by applying it to the anus. In order to confirm in more detail the effectiveness of the brown algae extract-containing acupuncture prevention liquid of this embodiment, an efficacy test was performed on 50 subjects. Although the number of subjects is as small as 50, since the hemorrhoid disease is a disease that develops in the anus, there is a current situation that subjects are difficult to gather due to the nature of the disease.

FIG. 5 shows a state outside the anus of the subject. In FIG. 5, 1 is an anus, 2 is wart, 3 is cut, 4 is itchy, and 5 is a symptom of swelling. As shown in Fig. 5, when classified according to the symptoms of the anal region, there are 3 injuries, 18 in one wart, 5 in 2 warts, 4 in warts, 4 in many warts, cuts / swells / itchiness There were 29 people. In addition, the test subject who has a symptom of cutting, swelling, and itch partially overlaps with a test subject having other symptoms.

FIG. 6 shows the state of the anus of the subject before using the brown algae extract-containing composition as a treatment / prevention solution for hemorrhoid diseases. As shown in FIG. 6, when classified by the onset of epilepsy disease, 11 were less than 1 year ago, 18 were less than 1-5 years ago, 11 were less than 6-19 years ago, and 10 were more than 20 years ago. It was a person. In addition, when classified according to the symptoms of hemorrhoid disease, there are 6 internal hemorrhoids, 28 external hemorrhoids and wart hemorrhoids, 12 swelling around the anus, 24 bleeding, 18 pains, 20 itch, cuts There were 13 people, 1 niece, and 3 others (free of charge). In addition, the test subject who has a symptom of cutting, swelling, and itch partially overlaps with a test subject having other symptoms.

FIG. 7 shows the usage frequency of the subject. As shown in FIG. 7, when classified according to frequency of use, 38 people once a day, 10 people twice a day, 0 people more than 3 times a day, 1 person every 2 to 3 days, 4 One person per day or more.

FIG. 8 shows the usage period of the subject. As shown in FIG. 8, when classified according to the period of use, 1 to 3 days are 0 people, 4 to 10 days are 15 people, 11 to 20 days are 27 people, 21 to 30 days are 4 people, 30 There were four people over the day.

FIG. 9 shows the state of the anus of the subject after using the brown algae extract-containing composition as a treatment / prevention solution for hemorrhoid diseases. As shown in FIG. 9, when classified according to the state of the anus after using the brown algae extract-containing acupuncture prevention liquid, there were 11 people who were considerably swollen, 12 people who were slightly swollen, and bleeding stopped There were 10 people, 9 people who stopped itching, 6 people who did not change much, and 2 people who did not change or deteriorated. Therefore, 42 of 50 test subjects, that is, 84%, had an improvement effect on epilepsy.

As explained above, the brown algae extract-containing composition according to the present embodiment is mainly composed of a brown algae extract having a solid content of 0.10 to 10.00% by weight excluding moisture, and the remaining components are at least 0.10 to Contains 10.00 wt% anti-inflammatory agent, 0.20-10.00 wt% aloe extract, and 0.10-5.00 wt% soluble protein component. According to the brown algae extract-containing composition according to the present embodiment, by using it as a treatment / prevention solution for hemorrhoid disease, induction of hemorrhoid disease can be prevented and improvement is promoted even when epilepsy disease has developed. Can do.
[Other Embodiments]

The preferred embodiments of the present invention have been described above, but these are examples for explaining the present invention, and the scope of the present invention is not limited to these embodiments. The brown algae extract-containing composition according to the present embodiment contains a brown algae extract as an active ingredient as a main component, and contains at least an anti-inflammatory agent, an aloe extract, and a soluble protein component as the remaining components. The above remaining components include water, ethanol and the like and are medically acceptable components, but may contain a preservative such as phenoxyethanol, for example. By containing a preservative, it is possible to prevent mold from occurring in the composition. In addition, a preservative is not limited to the illustrated chemical | medical agent, You may use other preservatives, such as sodium benzoate.

Moreover, the brown alga extract containing composition which concerns on this embodiment may contain gelling agents, such as a suntan gum, for example. By containing the gelling agent, it is possible to increase the holding power when applied to the anus as a treatment preventive solution. The gelling agent is not limited to the exemplified drugs, and other gelling agents such as gellan gum may be used. As described above, the present invention can be implemented in various modes different from the above-described embodiments without departing from the gist thereof.

The brown algae extract-containing composition and the brown algae extract-containing acupuncture preventive solution according to the present invention can prevent the induction of hemorrhoid disease or can promote improvement even if it has developed an epilepsy disease. Is expected to be widely applied as a composition that meets the standards for pharmaceuticals and quasi drugs in the Pharmaceutical Affairs Law.

1 anal part,
2 Warts,
3 slices,
4 Itching,
5 Swelling.

Claims

A brown algae extract-containing composition comprising a brown algae extract having a solid content of 0.10 to 10.00% by weight excluding moisture as a main component and a medically acceptable component as a remaining component.
2. The brown algae extract-containing composition according to claim 1, wherein the solid content of the brown algae extract is 0.10 to 3.00% by weight.
The remaining component includes at least 0.10 to 10.00% by weight of an anti-inflammatory agent, 0.20 to 10.00% by weight of aloe extract, and 0.10 to 5.00% by weight of soluble protein component. The brown algae extract containing composition of Claim 1 or Claim 2 to contain.
The brown alga extract-containing composition according to claim 3, wherein the anti-inflammatory agent contains at least one of glycyrrhizic acid 2K and allantoin.
4. The brown alga extract-containing composition according to claim 3, wherein the aloe extract contains at least one of aloe vera mesophyll, kidachi aloe mesophyll, cape aloe mesophyll, aloe vera leaf extract, kidachi aloe leaf extract, cape aloe leaf extract.
The brown alga extract-containing composition according to claim 3, wherein the soluble protein component is hydrolyzed silk.
The brown algae extract-containing composition according to any one of claims 1 to 6, wherein the brown algae extract-containing composition is used as a treatment / prevention liquid for acupuncture diseases.