WO2018201930A1

WO2018201930A1 - Automatic medication injection device

Info

Publication number: WO2018201930A1
Application number: PCT/CN2018/084235
Authority: WO
Inventors: 张艳; 梁曦; 王舒
Original assignee: 张艳
Priority date: 2017-05-04
Filing date: 2018-04-24
Publication date: 2018-11-08
Also published as: CN107050578A

Abstract

An automatic medication injection device, comprising: an injection unit (1), the injection unit (1) comprising at least two injection components (11), and each of the injection components (11) being used to inject medication; a calculation unit (2), the calculation unit (2) being used to calculate a total injection amount of the medication; and a control unit (3), the control unit (3) controlling the injection unit (1) on the basis of a calculation result from the calculation unit (2). The injection unit (1) comprises at least two injection components (11), thereby enabling simultaneous medication injections via the at least two injection components (11), effectively enlarging the area of medication injections, significantly reducing skin hard knots, and effectively improving medication absorption and therapeutic effects.

Description

Automatic drug injection device

Technical field

The present invention relates to an automatic drug injection device, and more particularly to an insulin injection device for a diabetic.

Background technique

Diabetes is a common disease in our lives. It is well known that diabetes is a group of metabolic diseases characterized by hyperglycemia, which is caused by the fact that the pancreas cannot produce a sufficient amount of insulin, which leads to a decrease in the body's ability to metabolize glucose, and thus to hyperglycemia (ie, excessive glucose in the plasma). ). Long-term studies have found that persistent hyperglycemia and / or hypoinsulinemia are associated with a variety of serious symptoms and life-threatening complications such as dehydration, ketoacidosis, cardiovascular disease, chronic renal failure, retinal damage and each Neuropathy. With the improvement of living standards, the incidence of diabetes is also increasing. Especially in recent years, the prevalence of diabetes in China has shown a trend of rapid increase and rejuvenation.

However, the current medical level is still not developed enough, and no method for radical treatment has been found. The blood sugar of the diabetic patient can be detected by the detection method to adjust the dose of the hypoglycemic drug, thereby alleviating the symptoms of the patient. In the existing diabetes treatment methods, insulin injection is the most direct medical means to control diabetes. In recent years, the demand for automatic and portable insulin injection devices has been enormous. However, there are still many shortcomings in existing insulin injection devices:

Existing insulin injection devices generally use a conventional needle for insulin injection, and the needle has a significant pain when puncturing the skin. At the same time, if the user wears the existing insulin injection device for a long time and needs the needle to stay in the skin for a long time, it is necessary to take disinfection measures from time to time, otherwise the wound infection and allergies may be caused by sweat and the like. In addition, since the needle needs to penetrate the dermis layer for insulin injection, the needle is generally long, and long-term wear is also likely to cause scarring of the skin.

In addition, since the existing insulin injection device uses an ordinary needle for insulin injection, the injection position is concentrated, which tends to cause subcutaneous induration at the injection site, giving the patient an uncomfortable feeling. Further, due to the concentrated injection position, insulin absorption is likely to be slow, resulting in poor therapeutic effect.

Summary of the invention

The object of the present invention is to provide an automatic drug injection device, which can solve the problems of inconvenient use, painfulness to the patient, slow drug absorption, and poor therapeutic effect in the prior art drug injection device.

In order to solve the above problems, the present invention provides an automatic drug injection device comprising: an injection unit comprising at least two injection members, and each injection member is for injecting a drug; a calculation unit for calculating a drug The total injection volume; and the control unit, the control unit controls the injection unit according to the calculation result of the calculation unit; wherein the calculation unit is based on the patient's body weight, waist-to-hip ratio, blood triglyceride content, blood glucose monitoring value, and recent blood glucose change trend Calculate the total amount of drug injected.

According to the automatic medicine injection unit provided by the present invention, since the injection unit includes at least two injection parts, simultaneous injection of the medicine by the at least two injection parts can effectively increase the injection area of the medicine, significantly improve the skin induration, and effectively Enhance the absorption of the drug and enhance the therapeutic effect.

Further, according to another aspect of the present invention, there is provided an automatic drug injection device, wherein: the calculation unit is based on a patient's body weight, a waist-to-hip ratio, a blood triglyceride content, a single-day pre-prandial blood glucose monitoring mean value, and a three-day blood glucose change trend. Calculating the total amount of drug injected; and

The calculation unit calculates the total injection amount of the drug according to the following formula:

among them:

L ₁ : total injection amount of the drug calculated by the calculation unit (u);

K: body weight (Kg) of the subject to be injected;

Y: waist-to-hip ratio of the injected subject;

X: The content of triglyceride (mmol/L) in the blood of the subject to be injected, wherein:

When the triglyceride content is below 1.7: X=1;

When the triglyceride content is greater than 1.7 and below 2.5: X = 1.1;

When the triglyceride content is greater than 2.5 and below 5: X = 1.2;

When the triglyceride content is greater than 5 and below 10: X = 1.3;

When the triglyceride content is greater than 2.5 and less than 5: X = 1.4;

A: mean daily pre-meal blood glucose (mmol/L) of the injected subject;

a: The trend of pre-meal blood glucose changes within 3 days after injection, among which:

When the pre-meal blood glucose change within the three days of the injection is generally within ±5% of the initial measurement: a=1;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum value of blood glucose was less than 10% compared with the minimum blood glucose: a=1.1;

The pre-meal blood glucose changes generally increased during the three days after injection, and the maximum value of blood glucose increased by more than 10% and within 20% compared with the minimum blood glucose level: a=1.2;

The pre-meal blood glucose changes generally increased during the three days after injection, and the maximum value of blood glucose increased by more than 20% and within 30% compared with the minimum blood glucose level: a=1.3;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum blood glucose increased by more than 30% and within 40% compared with the minimum blood glucose: a=1.4;

The pre-meal blood glucose changes generally increased during the three days of the injection, and the maximum value of blood glucose increased by more than 40% compared with the minimum blood glucose level: a=1.5;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by less than 10% compared with the maximum blood glucose: a=0.9;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by more than 10% and within 20% compared with the maximum blood glucose: a=0.8;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by more than 20% and within 30% compared with the maximum blood glucose: a=0.7;

When the pre-meal blood glucose changes in the three days of the injection were generally downward, and the blood glucose minimum decreased by 40% compared with the maximum blood glucose: a=0.6.

Preferably, according to still another aspect of the present invention, there is provided an automatic drug injection device, wherein: the calculation unit is based on a patient's body weight, a waist-to-hip ratio, a blood triglyceride content, a single-day pre-prandial blood glucose monitoring mean, and a single-day meal. The mean value of post-blood glucose monitoring, and the trend of blood glucose changes within three days to calculate the total injection volume of the drug;

among them:

L ₂ : total injection amount of the drug calculated by the calculation unit (u);

K: body weight (Kg) of the subject to be injected;

Y: waist-to-hip ratio of the injected subject;

When the triglyceride content is below 1.7: X=1;

When the triglyceride content is greater than 1.7 and below 2.5: X = 1.1;

When the triglyceride content is greater than 2.5 and below 5: X = 1.2;

When the triglyceride content is greater than 5 and below 10: X = 1.3;

When the triglyceride content is greater than 2.5 and less than 5: X = 1.4;

A: mean daily pre-meal blood glucose (mmol/L) of the injected subject;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by 40% compared with the maximum blood glucose: a = 0.6;

B: mean blood glucose (mmol/L) after a single day of injection;

b: The trend of postprandial blood glucose changes within 3 days after injection, among which:

When the postprandial blood glucose change within the three days of the injection is generally within ±5% of the initial measurement: a=1;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of blood glucose increased by less than 10% compared with the minimum blood glucose level: a = 1.1;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of blood glucose increased by more than 10% and within 20% compared with the minimum blood glucose level: a = 1.2;

When the post-prandial blood glucose changes in the three-day injection were generally on the rise, and the maximum blood glucose increased by more than 20% and within 30% compared with the minimum blood glucose: a=1.3;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of blood glucose increased by more than 30% and within 40% compared with the minimum value of blood glucose: a = 1.4;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of the blood glucose increased by more than 40% compared with the minimum blood glucose level: a = 1.5;

When the post-meal blood glucose changes in the three-day injection group showed a general downward trend, and the blood glucose minimum decreased by less than 10% compared with the maximum blood glucose level: a=0.9;

When the post-meal blood glucose changes in the three-day injection group showed a general downward trend, and the blood glucose minimum decreased by more than 10% and was within 20% compared with the maximum blood glucose level: a=0.8;

When the blood glucose changes in the three days after the injection of the subject showed a general downward trend, and the blood glucose minimum decreased by more than 20% compared with the maximum blood glucose level and was within 30%: a = 0.7;

When the post-meal blood glucose changes in the three-day injection group showed a general downward trend, and the blood glucose minimum decreased by 40% compared with the maximum blood glucose level: a=0.6;

The amount of drug injection before breakfast L ₂₁ = L ₂ × 0.6; the amount of drug injection before dinner L ₂₂ = L ₂ × 0.4.

As described above, according to the automatic drug injection unit provided by the present invention, the calculation unit calculates the total injection amount of the drug according to the patient's body weight, waist-to-hip ratio, blood triglyceride content, blood glucose monitoring value, and recent blood glucose change tendency, thereby comparing The existing insulin injection device can perform insulin injection with accurate values according to the patient's own characteristics, thereby avoiding the uncomfortable influence on the patient due to insufficient medication or excessive medication.

Preferably, according to another aspect of the present invention, there is provided an automatic drug injection device, wherein: the injection unit further comprises a drug storage member, a drug dispensing passage, and a syringe pump; and, the control unit performs a syringe pump according to a calculation result of the calculation unit Control is performed to deliver the drug in the drug storage component to the injection component through the drug delivery path in the desired amount.

Preferably, the automatic drug injection device according to another aspect of the present invention, further comprising: a substrate formed of a flexible material; wherein each of the injection members in the injection unit is formed to be attached to the substrate at one end One side surface of the needle-shaped member having a fluid passage formed therein; and the other end of each injection member is formed as a tip end.

Preferably, the automatic drug injection device according to another aspect of the present invention further includes: an input unit, the user can input the personal information into the automatic drug injection device through the input unit, and the calculation unit inputs the personal information according to the user. Performing a calculation; and setting a unit that sets the automatic drug injection device; and the input unit and the setting unit are electrically connected to the control unit.

Further, the automatic drug injection device according to another aspect of the present invention further includes: a display unit configured to display a calculation result of the calculation unit; and a storage unit that stores the calculation result of the calculation unit; The display unit and the storage unit are electrically connected to the control unit, respectively.

Further, the automatic drug injection device according to another aspect of the present invention further includes: a prompting unit, when the calculation result of the calculating unit is less than a preset threshold, the prompting unit issues a prompt to the user; and, the prompting unit and The control unit is electrically connected.

Preferably, the automatic drug injection device according to another aspect of the present invention further includes: a transmitting unit configured to transmit a calculation result of the computing unit and/or a calculation result stored in the storage unit.

Preferably, according to another aspect of the present invention, there is provided an automatic drug injection device, wherein: the calculation unit, the display unit, the storage unit, the input unit, the setting unit, the transmitting unit, and the control unit are packaged in the same housing.

In order to make the above description of the present invention more comprehensible, the preferred embodiments will be described below in detail with reference to the accompanying drawings.

DRAWINGS

The invention will now be described with reference to the accompanying drawings.

Figure 1 is a schematic view showing the frame of an automatic drug injection device according to the present invention;

Figure 2a is a side elevational view showing the injection unit 1 and the substrate 12 of the automatic drug injection device according to the present invention;

Fig. 2b is a perspective view showing the structure of the injection unit 1 and the substrate 12 of the automatic drug injection device according to the present invention.

detailed description

The embodiments of the present invention are described in the following specific embodiments, and those skilled in the art can readily understand other advantages and functions of the present invention from the disclosure.

As shown in the accompanying drawings 1 to 2b, the present invention provides an automatic drug injection device comprising: an injection unit 1 comprising at least two injection members 11, and each injection member 11 is used for injection Drug; calculation unit 2 for calculating the total injection amount of the medicine; and control unit 3, which controls the injection unit 1 according to the calculation result of the calculation unit 2. Further, according to the automatic drug injection device of the present invention, the calculation unit 2 calculates the total injection amount of the drug based on the patient's body weight, waist-to-hip ratio, blood triglyceride content, blood glucose monitoring value, and recent blood glucose change tendency. More specifically, according to the automatic drug injection device provided by the present invention, the injection member 11 may be an implantable syringe, or other internal syringes may be used for insertion of veins or other parts of the body containing body fluids.

As described above, according to the automatic drug injection unit of the present invention, since the injection unit 1 includes at least two injection members 11, the drug injection can be simultaneously performed by the at least two injection members 11, which can effectively increase the injection area of the drug. Improves skin induration and effectively enhances drug absorption and enhances therapeutic effects.

Further, an automatic drug injection device according to a preferred embodiment of the present invention, wherein: the calculation unit 2 is based on the patient's body weight, waist-to-hip ratio, blood triglyceride content, single-day pre-prandial blood glucose monitoring average, and within three days. The blood glucose change trend calculates the total injection volume of the drug. and:

The calculation unit 2 calculates the total injection amount of the medicine according to the following formula:

among them:

K: body weight (Kg) of the subject to be injected;

Y: waist-to-hip ratio of the injected subject;

When the triglyceride content is below 1.7: X=1;

When the triglyceride content is greater than 1.7 and below 2.5: X = 1.1;

When the triglyceride content is greater than 2.5 and below 5: X = 1.2;

When the triglyceride content is greater than 5 and below 10: X = 1.3;

When the triglyceride content is greater than 2.5 and less than 5: X = 1.4;

A: mean daily pre-meal blood glucose (mmol/L) of the injected subject;

More specifically, the inventors of the present invention verified the insulin injection amount of 20 typical patients by a large number of samplings, and the specific data table is shown in Table 1 below:

Table 1

As can be seen from the above table, according to the calculation method provided by the present invention, it is possible to accurately calculate the amount of insulin injection before the patient's meal for each patient's different physical condition, thereby making personalized treatment. More specifically, the automatic drug injection device according to the present invention is calculated according to the patient's body weight, waist-to-hip ratio, blood triglyceride content, single-day pre-prandial blood glucose monitoring mean value, and pre-prandial blood glucose change trend within three days. Unit 2 calculates the total amount of one-day pre-meal injection of insulin and injects it by the injection unit 1 prior to the meal to provide targeted, personalized treatment for each patient.

Furthermore, in the automatic drug injection device according to another preferred embodiment of the present invention, the calculation unit 2 calculates the mean value according to the patient's body weight, waist-to-hip ratio, blood triglyceride content, and single-day pre-prandial blood glucose monitoring. The average daily blood glucose monitoring, and the trend of blood glucose changes within three days to calculate the total injection volume of the drug;

among them:

K: body weight (Kg) of the subject to be injected;

Y: waist-to-hip ratio of the injected subject;

When the triglyceride content is below 1.7: X=1;

When the triglyceride content is greater than 1.7 and below 2.5: X = 1.1;

When the triglyceride content is greater than 2.5 and below 5: X = 1.2;

When the triglyceride content is greater than 5 and below 10: X = 1.3;

When the triglyceride content is greater than 2.5 and less than 5: X = 1.4;

A: mean daily pre-meal blood glucose (mmol/L) of the injected subject;

B: mean blood glucose (mmol/L) after a single day of injection;

More specifically, the inventors of the present invention verified the insulin injection amount of the 20 typical patients listed in Table 1 above, and the specific data table is shown in Table 2 below:

Table 2

As can be seen from the above table, the method for calculating the total amount of insulin injection provided according to the present invention can accurately calculate the total daily insulin injection amount of the patient for each patient's different physical condition. Further, based on the calculated total daily insulin injection of the patient, the patient's pre-breakfast insulin injection L ₂₁ and the pre-dinner insulin injection L _{22 are} further calculated. More specifically, according to the method for calculating the total amount of insulin injection provided by the present invention, for a patient who needs to inject two insulins daily, the amount of drug injection before breakfast is L ₂₁ = L ₂ × 0.6; the amount of drug injection before dinner L ₂₂ = L ₂ × 0.4.

More specifically, the automatic drug injection device according to the present invention is based on the patient's body weight, waist-to-hip ratio, blood triglyceride content, single-day pre-prandial blood glucose monitoring mean, single-day postprandial blood glucose monitoring mean, and three The intraday blood glucose change trend, the calculation unit 2 accurately calculates the total daily injection amount L ₂ of each patient's insulin, and thereby obtains the patient's pre-breakfast drug injection amount L ₂₁ and the pre-dinner drug injection amount L ₂₂ , and Further precise injections are made by the injection unit 1 before breakfast and before dinner, so that targeted, personalized treatment is provided for each patient.

That is to say, according to the automatic drug injection device provided by the present invention, the injection unit 1 can perform accurate quantitative drug injection before breakfast and/or before dinner according to the calculation result of the calculation unit 2 for each patient's own specific situation. In order to make targeted and personalized treatment for each patient, compared with the existing insulin injection device, it is possible to accurately inject insulin according to the patient's own characteristics, thereby avoiding the lack of medication or Excessive use of the drug has an uncomfortable effect on the patient. Further, since the injection unit 1 includes at least two injection members 11, the simultaneous injection of the drug by the at least two injection members 11 can effectively increase the injection area of the drug, significantly improve the skin induration, and effectively enhance the drug absorption effect. Improve the treatment effect. Still further, according to a preferred embodiment of the present invention, the injection unit 1 includes a plurality of injection members 11 arranged in an array, so that the drug injection area can be most effectively increased, the skin induration is improved, and the drug absorption effect is enhanced.

Preferably, the automatic drug injection device according to the present invention, wherein the injection unit 1 further includes a drug storage member (not shown), a drug dispensing passage 13, and a syringe pump (not shown); and, the control unit 3 Based on the calculation result of the calculation unit 2, the syringe pump is controlled to deliver the medicine in the drug storage member to the respective injection members through the drug distribution path in the required amount. It should be noted here that although the structure of the drug storage component, the drug distribution channel 13 and the syringe pump is not illustrated in the drawings of the present invention, it can be arbitrarily selected by those skilled in the art according to actual design and use requirements. The specific configuration of the drug storage member, the drug dispensing passage 13 and the syringe pump is provided, which does not require any additional inventive work.

Still further, the automatic drug injection device according to the present invention further includes: a substrate 12 formed of a flexible material. Further, each of the injection members 11 in the injection unit 1 is formed as a needle having a fluid passage formed therein with one end attached to one side surface of the substrate 12 (i.e., a side surface facing the human body surface in use) And the other end of each injection member 11 is formed as a tip end, and when the injection member 11 is inserted into the patient's skin, the drug flows from the drug storage member into the fluid passage inside each injection member 11 through the drug distribution passage 13 and passes through each The tip end of the injection member 11 flows into the patient.

More specifically, in the preferred embodiment of the invention, the substrate 12 is flexible to reduce pain and tissue damage caused by implantation and/or wearing of the injection unit 1. The flexible substrate 12 generally increases patient comfort and allows the patient to have a greater range of motion. Suitable materials for the flexible substrate 12 include materials such as non-conductive plastics or polymers and other non-conductive, flexible, deformable materials. Examples of useful plastic or polymeric materials include thermoplastics such as polycarbonate, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyurethane, polyether, polyamide, polyimide. , or a copolymer of these thermoplastics, such as PETG (ethylene glycol modified polyethylene terephthalate).

Still further, the substrate 12 in the automatic drug injection device according to the present invention may also be rigid depending on actual use and design requirements. The rigid substrate 12 can be used to provide structural support to the injection unit 1 to resist bending or cracking. More specifically, examples of the rigid material that can be used as the substrate 12 include ceramics having poor conductivity such as alumina and silica. Another advantage of using a rigid substrate 12 is that it helps to detect that the injection member 11 is inserted without the need for additional insertion of the device.

When using the automatic drug injection device according to the preferred embodiment of the present invention, the user inserts the injection member 11 provided on the substrate 12 into a predetermined position on the surface of the human body such that each injection member 11 is located in a vein or contains body fluid. Part. Still further, for example, implantation of the injection member 11 can be performed in a venous system for directly injecting a drug into the blood. Alternatively, the injection component 11 can be implanted into the interstitial tissue for injection of the drug into the interstitial fluid. In this case, the position and depth of implantation of the injection member 11 can affect the specific shape, components, and structure of the injection member 11.

Still further, in accordance with a preferred embodiment of the present invention, the injection member 11 disposed on the substrate 12 is inserted into the interstitial tissue of the patient (between 0.3 mm and 5 mm). Preferably, it is inserted into the interstitial tissue, 0.5 mm to 3 mm, more preferably 0.5 mm to 1.5 mm. Other embodiments of the invention may include an injection unit 1 that is inserted into other parts of the patient, such as a vein or an organ. The depth of implantation varies depending on the target to be implanted. Further, a viscous substance may be applied on the surface of the substrate 12 on which the injection member 11 is provided, so that the injection member 11 is fixed to the patient through the viscous substance on the surface of the substrate 12 after the injection member 11 is inserted into the epidermis of the patient. The body is thereby convenient for the patient to re-insert the injection member 11 each time for a period of time.

Further, the insertion angle is measured from the skin surface (i.e., the insertion angle should be 90° perpendicular to the skin insertion sensor). The insertion angle is typically in the range of 10° to 90°, typically 15° to 60°, and more often 30° to 45°.

More specifically, according to the automatic drug injection device of the preferred embodiment of the present invention, each injection member 11 is substantially smaller in size than a conventional syringe needle, thereby performing drug injection using the injection member 11 provided by the present invention. The pain of the patient is greatly reduced, and since the skin penetration depth of the injection member 11 is small, the wound infection is not caused, and the scar is not left due to the long-term wearing of the injection unit 1.

Therefore, with such a structure, the patient can greatly reduce the pain of the patient when using the automatic drug injection device provided by the present invention. Still further, optionally, the substrate 12 and the injection member 11 in the automatic drug injection device according to the present invention are formed into a shape that is comfortable for the patient, which may be allowed to be hidden under the clothes of, for example, a patient. For the patient, the thigh, leg, upper arm, shoulder or abdomen are the more convenient locations on the patient's body for placing the injection component 11 to remain hidden. However, the injection member 11 can also be placed in other parts of the patient's body. It should be noted that the specific structure of the injection component 11 is only illustrated in the drawings of the present invention. For those skilled in the art, the structure of the injection component 11 can be arbitrarily selected according to actual design and use requirements. For example, the injection member 11 can be a planar osmotic injection structure, or any other structure capable of achieving the purpose of injection, without any additional inventive work. Further, the injection member 11 according to the present invention may be made of dimethyl siloxane (PDMS) or the like, and the surface may be coated with various anti-corrosion layers to function as a seal.

Moreover, for those skilled in the art, rigid and flexible substrates can be suitably used for many injection components 11 depending on the particular use and design requirements, as well as by, for example, changing the composition of the substrate 12 and / or thickness to continuously change its flexibility. These can all be determined by one skilled in the art based on the particular use and design needs.

Further, the automatic drug injection device according to the present invention further includes: an input unit 4 through which the user can input personal information into the automatic drug injection device. More specifically, the user can input personal information such as his own weight, blood triglyceride content, blood glucose monitoring value and the like into the automatic drug injection device through the input unit 4, and then the calculation unit 2 according to the personal information input by the user, according to the present The method for calculating the total amount of insulin injection provided by the invention is calculated to obtain the total amount of insulin injection corresponding to the personal information, and further, the injection unit 1 performs the injection. Further, the automatic drug injection device according to the present invention further includes a setting unit 5 by which the user can set the automatic drug injection device provided by the present invention. More specifically, the user can set the automatic drug injection device provided by the present invention through the setting unit 5, for example, the use condition of the automatic drug injection device by the setting unit 5 (for example, the meal time of the patient) The setting of the automatic injection device of the drug, etc., is set, so that the user can use the automatic injection device of the drug according to his actual needs. Further, according to the automatic drug injection device provided by the present invention, the setting unit 5 is electrically connected to the control unit 3, so that various settings of the automatic drug injection device made by the user through the setting unit 5 can pass through the control unit 3. Control each other unit.

Further, according to the automatic drug injection device provided by the present invention, the input unit 4 and the setting unit 5 are electrically connected to the control unit 3, respectively, so that the input unit 4 and the setting unit 5 are controlled by the control unit 3, while the input unit 4 is simultaneously Various feedbacks with the setting unit 5 can also be fed back to the other individual units through the control unit 4.

Further, the automatic drug injection device according to the present invention further includes: a display unit 6 for displaying a calculation result of the calculation unit 2. More specifically, as described above, according to the automatic drug injection device provided by the preferred embodiment of the present invention, the calculation unit 2 performs calculation based on the personal information of the patient to obtain an insulin injection amount for the individual patient. Further, the calculation result of the calculation unit 2 is displayed by the display unit 6, so that the patient can visually and immediately see the calculation result of the calculation unit 2 through the display unit 6, thereby knowing the total amount of drugs to be injected into the body, and understanding the disease treatment. status. In addition, the display unit 6 can also display personal information such as body weight, blood triglyceride content, blood glucose monitoring value input by the patient through the input unit 4, thereby understanding his or her physical condition. Further, the automatic drug injection device according to the present invention further includes a storage unit 7, which stores the calculation result of the calculation unit 2. More specifically, the storage unit 7 can be arranged to store a plurality of calculation results of the computing unit 2 for a period of time (for example, 72 hours or longer), thereby facilitating the user from the storage unit 7 to the time. The calculation results in the cycle are extracted and analyzed, and the use of the drug in the time period, as well as the state change of the body, and various adjustments are further obtained.

Further, according to the analyte monitoring device provided by the present invention, the display unit 6 and the storage unit 7 are electrically connected to the control unit 3, respectively, so that the display unit 6 and the storage unit 7 are controlled by the control unit 3, while the display unit 6 and the storage unit are simultaneously stored. The various feedbacks of unit 7 can also be fed back to the other individual units via control unit 3.

Further, the automatic drug injection device according to the present invention further includes a prompting unit 8 that issues a prompt to the user when the calculation result of the calculating unit 2 is less than a preset threshold. More specifically, in the automatic drug injection device according to the preferred embodiment of the present invention, the prompting unit 8 compares the insulin injection amount calculated by the calculation unit 2 (i.e., L ₁ or L ₂ as described above) with The set threshold is compared, and when the calculation result of the calculation unit 2 (ie, the insulin injection amount) is less than a preset threshold, the prompting unit 8 issues a prompt to the user. More specifically, for example, according to a preferred embodiment of the present invention, a preset threshold may be stored in the control unit 3 or the prompting unit 8, and the threshold may be 5u (corresponding to the L ₁ calculated by the computing unit 2) ) or 10U (corresponding to the calculated calculation unit 2 L _2), if calculated by the calculating unit 2 is smaller than L ₁ of 5U (or computing unit 2 is smaller than the calculated 10U L _2), then sent to the user prompting unit 8 The prompt prompts the user to choose not to inject insulin in this case, and to control the blood sugar in the body by oral medication or, for example, controlling diet. More specifically, the cueing unit 8 may include a component that prompts the user by a lamp or sound, such as a sounding component or a lighting component.

Further, according to the automatic drug injection device provided by the present invention, the prompting unit 8 is electrically connected to the control unit 3, so that the prompting unit 8 is controlled by the control unit 3, and various feedbacks of the prompting unit 8 can also be fed back through the control unit 3. Go to each other unit. For example, when the prompting unit 8 issues a prompt to the user, the control unit 3 controls the injection unit 1 not to inject the patient according to the feedback of the prompting unit 8, thereby facilitating the patient to control the blood sugar in the body by oral medication or, for example, controlling diet. .

Still further, an analyte monitoring apparatus according to another aspect of the present invention further includes: a transmitting unit 9 for transmitting a calculation result of the calculation unit 2 and/or a calculation result stored in the storage unit 7. More specifically, according to a preferred embodiment of the present invention, the transmitting unit 9 can transmit the calculation result of the computing unit 2 and the manner of wired (for example, a data transmission line) or wireless (for example, a wireless network, Bluetooth transmission, etc.). / or the calculation result stored in the storage unit 7. Thereby the user can obtain the calculation result of the calculation unit 2 and/or the calculation result stored in the storage unit 7 by, for example, a wired/wireless handheld device. Further, if the application software (mobile phone App) adapted to the automatic drug injection device provided by the present invention is installed in the user's mobile phone, it can be paired with the transmitting unit 9 (for example, Bluetooth pairing, wireless network pairing, etc.) Therefore, the calculation result of the calculation unit 2 and/or the calculation result stored in the storage unit 7 can be easily obtained on the mobile phone, and the physical state of the patient can be grasped at any time. In addition, for medical institutions, it is also possible to classify multiple patients' autonomic injection devices into the same wireless network, thereby enabling real-time monitoring of the physical state and treatment status of multiple patients, and abnormalities in the patient's physical state. Immediately issue a warning.

Preferably, the automatic drug injection device according to the present invention: the calculation unit 2, the input unit 4, the setting unit 5, the display unit 6, the storage unit 7, the prompting unit 8, the transmitting unit 9, and the control unit 3 are packaged in the same In the housing. More preferably, in the preferred embodiment of the present invention, the drug storage member (not shown) included in the injection unit 1 and a syringe pump (not shown) are also included in the same casing and through the drug distribution path. It is in fluid communication with the injection component 11. Further, in a preferred embodiment of the invention, the housing is at least waterproof to prevent inflow of liquid into contact with components in the housing. In some embodiments, the housing is formed as a sealed, waterproof or water resistant seal so that liquid cannot flow into the interior of the housing, which is very useful when the user is performing activities such as showering, bathing or swimming. In addition, the shape of the housing may be arbitrarily selected according to actual design and use requirements. For example, the housing may be formed in a circular, elliptical or other various shape as long as it is adapted to the user's body.

Further, it is to be noted here that the preferred embodiment of the present invention only describes a drug (insulin) injection method for treating a disease (diabetes). However, it will be readily apparent to those skilled in the art that the automatic drug injection device provided by the present invention can be used for drug injection of various diseases, for example, for controlling injection of drugs such as hyperlipemia and hypertension. This can be arbitrarily chosen according to the actual use, which does not require any additional creative labor.

The above-described embodiments are merely illustrative of the principles of the invention and its effects, and are not intended to limit the invention. Modifications or variations of the above-described embodiments may be made by those skilled in the art without departing from the spirit and scope of the invention. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and scope of the invention will be covered by the appended claims.

Claims

An automatic drug injection device, comprising:

An injection unit comprising at least two injection parts, and each injection part is for injecting a drug;

a calculation unit for calculating a total injection amount of the medicine; and

a control unit, wherein the control unit controls the injection unit according to a calculation result of the calculation unit;

The calculation unit calculates the total injection amount of the drug according to the patient's body weight, waist-to-hip ratio, blood triglyceride content, blood glucose monitoring value, and recent blood glucose change trend.
The automatic drug injection device according to claim 1, wherein:

The calculating unit calculates a total injection amount of the medicine according to a patient's body weight, a waist-to-hip ratio, a blood triglyceride content, a pre-prandial blood glucose monitoring value, and a three-day blood glucose change trend;

The calculation unit calculates the total injection amount of the medicine according to the following formula:

among them:

L 1 : the total injection amount (u) of the drug calculated by the calculation unit;

K: body weight (Kg) of the subject to be injected;

Y: waist-to-hip ratio of the injected subject;

X: The content of triglyceride (mmol/L) in the blood of the subject to be injected, wherein:

When the triglyceride content is below 1.7: X=1;

When the triglyceride content is greater than 1.7 and below 2.5: X = 1.1;

When the triglyceride content is greater than 2.5 and below 5: X = 1.2;

When the triglyceride content is greater than 5 and below 10: X = 1.3;

When the triglyceride content is greater than 2.5 and less than 5: X = 1.4;

A: mean daily pre-meal blood glucose (mmol/L) of the injected subject;

a: The trend of pre-meal blood glucose changes within 3 days after injection, among which:

When the pre-meal blood glucose change within the three days of the injection is generally within ±5% of the initial measurement: a=1;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum value of blood glucose was less than 10% compared with the minimum blood glucose: a=1.1;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum value of blood glucose was greater than 10% and within 20% of the minimum value of blood glucose: a=1.2;

The pre-meal blood glucose changes generally increased during the three days after injection, and the maximum value of blood glucose increased by more than 20% and within 30% compared with the minimum blood glucose level: a=1.3;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum blood glucose increased by more than 30% and within 40% compared with the minimum blood glucose: a=1.4;

The pre-meal blood glucose changes generally increased during the three days of the injection, and the maximum value of blood glucose increased by more than 40% compared with the minimum blood glucose level: a=1.5;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by less than 10% compared with the maximum blood glucose: a=0.9;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by more than 10% and within 20% compared with the maximum blood glucose: a=0.8;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by more than 20% and within 30% compared with the maximum blood glucose: a=0.7;

When the pre-meal blood glucose changes in the three days of the injection were generally downward, and the blood glucose minimum decreased by 40% compared with the maximum blood glucose: a=0.6.
The automatic drug injection device according to claim 1, wherein:

The calculating unit calculates the total injection amount of the medicine according to the patient's body weight, waist-to-hip ratio, blood triglyceride content, pre-prandial blood glucose monitoring value, postprandial blood glucose monitoring value, and three-day blood glucose change trend;

The calculation unit calculates the total injection amount of the medicine according to the following formula:

among them:

L 2 : the total injection amount (u) of the drug calculated by the calculation unit;

K: body weight (Kg) of the subject to be injected;

Y: waist-to-hip ratio of the injected subject;

X: The content of triglyceride (mmol/L) in the blood of the subject to be injected, wherein:

When the triglyceride content is below 1.7: X=1;

When the triglyceride content is greater than 1.7 and below 2.5: X = 1.1;

When the triglyceride content is greater than 2.5 and below 5: X = 1.2;

When the triglyceride content is greater than 5 and below 10: X = 1.3;

When the triglyceride content is greater than 2.5 and less than 5: X = 1.4;

A: mean daily pre-meal blood glucose (mmol/L) of the injected subject;

a: The trend of pre-meal blood glucose changes within 3 days after injection, among which:

When the pre-meal blood glucose change within the three days of the injection is generally within ±5% of the initial measurement: a=1;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum value of blood glucose was less than 10% compared with the minimum blood glucose: a=1.1;

The pre-meal blood glucose changes generally increased during the three days after injection, and the maximum value of blood glucose increased by more than 10% and within 20% compared with the minimum blood glucose level: a=1.2;

The pre-meal blood glucose changes generally increased during the three days after injection, and the maximum value of blood glucose increased by more than 20% and within 30% compared with the minimum blood glucose level: a=1.3;

When the pre-meal blood glucose changes in the three days of the injection were generally on the rise, and the maximum blood glucose increased by more than 30% and within 40% compared with the minimum blood glucose: a=1.4;

The pre-meal blood glucose changes generally increased during the three days of the injection, and the maximum value of blood glucose increased by more than 40% compared with the minimum blood glucose level: a=1.5;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by less than 10% compared with the maximum blood glucose: a=0.9;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by more than 10% and within 20% compared with the maximum blood glucose: a=0.8;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by more than 20% and within 30% compared with the maximum blood glucose: a=0.7;

When the pre-meal blood glucose changes in the three days of the injection were generally decreased, and the blood glucose minimum decreased by 40% compared with the maximum blood glucose: a = 0.6;

B: mean blood glucose (mmol/L) after a single day of injection;

b: The trend of postprandial blood glucose changes within 3 days after injection, among which:

When the postprandial blood glucose change within the three days of the injection is generally within ±5% of the initial measurement: a=1;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of blood glucose increased by less than 10% compared with the minimum blood glucose level: a = 1.1;

The postprandial blood glucose changes generally increased during the three days after injection, and the maximum value of blood glucose increased by more than 10% and within 20% compared with the minimum value of blood glucose: a=1.2;

When the post-prandial blood glucose changes in the three-day injection were generally on the rise, and the maximum blood glucose increased by more than 20% and within 30% compared with the minimum blood glucose: a=1.3;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of blood glucose increased by more than 30% and within 40% compared with the minimum value of blood glucose: a = 1.4;

When the blood glucose changes in the three days after the injection of the subject generally showed an upward trend, and the maximum value of the blood glucose increased by more than 40% compared with the minimum blood glucose level: a = 1.5;

When the post-meal blood glucose changes in the three-day injection group showed a general downward trend, and the blood glucose minimum decreased by less than 10% compared with the maximum blood glucose level: a=0.9;

When the post-meal blood glucose changes in the three-day injection group showed a general downward trend, and the blood glucose minimum decreased by more than 10% and was within 20% compared with the maximum blood glucose level: a=0.8;

When the blood glucose changes in the three days after the injection of the subject showed a general downward trend, and the blood glucose minimum decreased by more than 20% compared with the maximum blood glucose level and was within 30%: a = 0.7;

When the post-meal blood glucose changes in the three-day injection group showed a general downward trend, and the blood glucose minimum decreased by 40% compared with the maximum blood glucose level: a=0.6;

The amount of drug injection before breakfast L 21 = L 2 × 0.6;

The amount of drug injection before dinner L 22 = L 2 × 0.4.
The automatic drug injection device according to claim 2 or 3, wherein:

The injection unit further includes a drug storage component, a drug dispensing passage, and a syringe pump;

The control unit controls the syringe pump to transfer the drug in the drug storage component to the injection component through the drug dispensing path in accordance with a calculation result of the calculation unit.
The automatic drug injection device according to claim 4, further comprising:

a substrate formed of a flexible material; wherein

Each of the injection members of the injection unit is formed as a needle-like member having a fluid passage formed therein at one end attached to one side surface of the substrate;

The other end of each of the injection members is formed as a tip end.
The automatic drug injection device according to claim 5, further comprising:

An input unit, the user may input personal information into the automatic drug injection device through the input unit, and the calculation unit performs calculation according to the personal information input in the use;

a setting unit that sets the drug automatic injection device; and

The input unit and the setting unit are electrically connected to the control unit.
The automatic drug injection device according to claim 6, further comprising:

a display unit, the display unit is configured to display a calculation result of the calculation unit; and

a storage unit that stores a calculation result of the calculation unit; and

The display unit and the storage unit are respectively electrically connected to the control unit.
The automatic drug injection device according to claim 7, further comprising:

a prompting unit, when the calculation result of the calculating unit is less than a preset threshold, the prompting unit issues a prompt to the user;

The prompting unit is electrically connected to the control unit.
The analyte monitoring device of claim 8 further comprising:

a transmitting unit, configured to transmit a calculation result of the computing unit and/or a calculation result stored in the storage unit.
The analyte monitoring device of claim 9 wherein:

The computing unit, the display unit, the storage unit, the input unit, the setting unit, the prompting unit, the transmitting unit, and the control unit are packaged in the same housing.